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inflammatory breast cancer gene expression

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https://www.readbyqxmd.com/read/27881676/cytoplasmic-localization-of-proline-glutamic-acid-leucine-rich-protein-1-pelp1-induces-breast-epithelial-cell-migration-through-upregulation-of-inhibitor-of-kappa-b-kinase-epsilon-and-inflammatory-crosstalk-with-macrophages
#1
Brian J Girard, Todd P Knutson, Bethanie Kuker, Laura McDowell, Kathryn L Schwertfeger, Julie H Ostrander
Cytoplasmic localization of proline, glutamic acid, leucine rich protein 1 (PELP1) is observed in about 40% of women with invasive breast cancer. In mouse models, PELP1 overexpression in the mammary gland leads to pre-malignant lesions and eventually mammary tumors. In preliminary clinical studies, cytoplasmic localization of PELP1 was seen in 36% of women at high risk of developing breast cancer. Here, we investigated whether cytoplasmic PELP1 signaling promotes breast cancer initiation in models of immortalized human mammary epithelial cells (HMECs)...
November 23, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27865894/activation-of-peroxisome-proliferator-activated-receptor-gamma-in-mammary-epithelial-cells-upregulates-the-expression-of-tumor-suppressor-cyld-to-mediate-growth-inhibition-and-anti-inflammatory-effects
#2
Athanasios Pseftogas, Christos Gonidas, George Mosialos
Several studies have implicated the downregulation of the tumor suppressor Cyld expression in breast cancer development. However, the mechanisms that regulate Cyld expression in mammary epithelial cells are largely unknown. In order to investigate them, a bioinformatic analysis of the promoter region of Cyld was performed and identified putative nuclear hormone receptor response elements that included peroxisome proliferator-activated receptor gamma (PPAR-γ)-responsive elements. In the present study, we showed that upon activation of the nuclear hormone receptor PPAR-γ by the agonist troglitazone (TZD), there was a significant increase in Cyld mRNA in human mammary epithelial cell lines...
November 16, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27852980/aging-is-associated-with-an-expansion-of-cd49f-hi-mammary-stem-cells-that-show-a-decline-in-function-and-increased-transformation-potential
#3
Qiaoxiang Dong, Hui Gao, Yuanshuo Shi, Fuchuang Zhang, Xiang Gu, Anqi Wu, Danhan Wang, Yuanhong Chen, Abhik Bandyopadhyay, I-Tien Yeh, Benjamin J Daniel, Yidong Chen, Yi Zou, Vivienne L Rebel, Christi A Walter, Jianxin Lu, Changjiang Huang, Lu-Zhe Sun
Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age is unknown. We compared mammary epithelial cells isolated from young and old mammary glands of different cohorts of C57BL6/J and BALB/c mice, and our findings revealed that old mammary glands were characterized by increased basal cell pool comprised of mostly CD49f(hi) cells, altered luminal-to-basal cell ratio, and irregular ductal morphology...
November 15, 2016: Aging
https://www.readbyqxmd.com/read/27851913/regulatory-t-cells-exhibit-distinct-features-in-human-breast-cancer
#4
George Plitas, Catherine Konopacki, Kenmin Wu, Paula D Bos, Monica Morrow, Ekaterina V Putintseva, Dmitriy M Chudakov, Alexander Y Rudensky
Regulatory T (Treg) cells reside in lymphoid organs and barrier tissues where they control different types of inflammatory responses. Treg cells are also found in human cancers, and studies in animal models suggest that they contribute to cancer progression. However, properties of human intratumoral Treg cells and those present in corresponding normal tissue remain largely unknown. Here, we analyzed features of Treg cells in untreated human breast carcinomas, normal mammary gland, and peripheral blood. Tumor-resident Treg cells were potently suppressive and their gene-expression pattern resembled that of normal breast tissue, but not of activated peripheral blood Treg cells...
November 15, 2016: Immunity
https://www.readbyqxmd.com/read/27851813/pld-specific-small-molecule-inhibitors-decrease-tumor-associated-macrophages-and-neutrophils-infiltration-in-breast-tumors-and-lung-and-liver-metastases
#5
Karen M Henkels, Naveen Reddy Muppani, Julian Gomez-Cambronero
Phospholipase D-2 (PLD2) has a key role in breast cancer formation and metastasis formation with PLD small inhibitors reducing primary tumor growth. This study aimed to evaluate the importance of targeting PLD on the tumor microenvironment. We provide evidence about the beneficial effect of PLD inhibitors [FIPI (dual PLD1/PLD2) or VU0155072-2 (PLD2 inhibitor)] on avoiding infiltration of tumor-helping macrophages and neutrophils. Tumor growth and metastasis within the primary tumors had low (<20% over controls) PLD enzyme activity...
2016: PloS One
https://www.readbyqxmd.com/read/27847208/synthesis-and-characterization-of-chrysin-loaded-pcl-peg-pcl-nanoparticle-and-its-effect-on-breast-cancer-cell-line
#6
Ali Eatemadi, Hadis Daraee, Hammed T Aiyelabegan, Babak Negahdari, Bahram Rajeian, Nosratollah Zarghami
BACKGROUND: Nano-therapy exhibit the potential of revolutionizing cancer therapy. This field introduces nanovectors/nanocarriers for anticancer drugs targeted delivery, and also finds application in imaging. Chrysin, a natural flavonoid, was recently studied as having important biological roles in chemical defenses, nitrogen fixation, anti-inflammatory, and anti-oxidant properties. We aim at studying the effect of nano-chrysin on breast cancer cell line. METHODS: The effect of chrysin loaded PCL-PEG-PCL was studied on T47D breast cancer cell line...
November 12, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27820834/ccl2-ccr2-regulates-the-tumor-microenvironment-in-her-2-neu-driven-mammary-carcinomas-in-mice
#7
Xuguang Chen, Yunyue Wang, David Nelson, Sara Tian, Erin Mulvey, Bhumi Patel, Ilaria Conti, Juan Jaen, Barrett J Rollins
Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear. Here we report that CCL2 promotes mammary carcinoma development in a clinically relevant murine model of breast cancer. Targeted disruption of Ccl2 slowed the growth of activated Her2/neu-driven mammary tumors and prolonged host survival. Disruption of Ccl2 was associated with a decrease in the development and mobilization of endothelial precursor cells (EPCs) which can contribute to tumor neovascularization...
2016: PloS One
https://www.readbyqxmd.com/read/27761799/neuropeptide-levels-as-well-as-neprilysin-activity-decrease-in-renal-cell-carcinoma
#8
Nuray Erin, Tümay İpekçi, Bahar Akkaya, İrem Hicran Özbudak, Mehmet Baykara
Calcitonin Gene-related Peptide (CGRP), Vasoactive Intestinal Peptide (VIP) and Substance P (SP) are sensory neuropeptides which may alter cancer growth through modulation of chronic inflammation. We recently reported that SP suppresses breast cancer growth and metastasis through neuroimmune modulation. These neuropeptides are hydrolyzed by Neprilysin (NEP) to bioactive fragments. Decreased activity of NEP was reported in clear cell and chromophobe type renal cell carcinoma (RCC). It is however not known how the levels of neuropeptides hydrolyzed with NEP changes in RCC...
October 19, 2016: Cancer Microenvironment: Official Journal of the International Cancer Microenvironment Society
https://www.readbyqxmd.com/read/27717868/intermittent-hypoxia-confers-pro-metastatic-gene-expression-selectively-through-nf-%C3%AE%C2%BAb-in-inflammatory-breast-cancer-cells
#9
Katrin Gutsche, Elisa B Randi, Volker Blank, Daniel Fink, Roland H Wenger, Cornelia Leo, Carsten C Scholz
Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer. Treatment options are limited and the mechanisms underlying its aggressiveness are poorly understood. Intermittent hypoxia (IH) causes oxidative stress and is emerging as important regulator of tumor metastasis. Vessels in IBC tumors have been shown to be immature, which is a primary cause of IH. We therefore investigated the relevance of IH for the modulation of gene expression in IBC cells in order to assess IH as potential regulator of IBC aggressiveness...
October 5, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27701469/impact-of-tnf-%C3%AE-rs1800629-and-il-6-rs1800795-polymorphisms-on-cognitive-impairment-in-asian-breast-cancer-patients
#10
Jung-Woo Chae, Terence Ng, Hui Ling Yeo, Maung Shwe, Yan Xiang Gan, Han Kiat Ho, Alexandre Chan
OBJECTIVE: Expression of pro-inflammatory cytokines is influenced by single nucleotide polymorphisms (SNPs) in the promoter regions of the pro-inflammatory cytokine genes, and cytokines are associated with the occurrence of post-chemotherapy cognitive impairment. Hence, the aim of this study was to evaluate the associations between two common pro-inflammatory cytokine gene polymorphisms namely, IL6-174 (rs1800795 G>C) and TNF-308 (rs1800629 G>A), and chemotherapy-associated cognitive impairment (CACI) among Asian early-stage breast cancer patients...
2016: PloS One
https://www.readbyqxmd.com/read/27689900/stress-management-leukocyte-transcriptional-changes-and-breast-cancer-recurrence-in-a-randomized-trial-an-exploratory-analysis
#11
Michael H Antoni, Laura C Bouchard, Jamie M Jacobs, Suzanne C Lechner, Devika R Jutagir, Lisa M Gudenkauf, Charles S Carver, Susan Lutgendorf, Steven W Cole, Marc Lippman, Bonnie B Blomberg
PURPOSE: Cognitive behavioral stress management (CBSM) is an empirically-validated group-based psychosocial intervention. CBSM is related to decreased self-reported indicators of psychological adversity during breast cancer treatment and greater disease-free survival (DFS) vs. a control condition. This study examined relationships between CBSM, DFS, and a potential biobehavioral pathway linking these variables in breast cancer patients through a gene expression composite representing the leukocyte conserved transcriptional response to adversity (CTRA)...
September 24, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27666521/pro-adhesive-phenotype-of-normal-endothelial-cells-responding-to-metastatic-breast-cancer-cell-conditioned-medium-is-linked-to-nf%C3%AE%C2%BAb-mediated-transcriptomic-regulation
#12
Janini Mejía-Rangel, Emilio Córdova, Lorena Orozco, José Luis Ventura-Gallegos, Irma Mitre-Aguilar, Alma Escalona-Guzmán, Felipe Vadillo, José Vázquez-Prado, Patricio Gariglio, Alejandro Zentella-Dehesa
Tumor microenvironment is an important promoter of tumorigenesis in all forms of breast cancer and has been associated with the risk of metastasis in the different breast cancer subtypes including the more frequent luminal subtypes that encompass 60% of cancer patients. Adhesive properties of endothelial cells (ECs) are strikingly affected during cancer cell dissemination and are related to functional changes of adhesion receptors. The contribution of tumor secreted factors to tumor‑EC adhesion represents a therapeutic opportunity for breast cancer metastasis...
November 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27659519/profiles-of-mirnas-matched-to-biology-in-aromatase-inhibitor-resistant-breast-cancer
#13
Reiner Hoppe, Ping Fan, Florian Büttner, Stefan Winter, Amit K Tyagi, Heather Cunliffe, V Craig Jordan, Hiltrud Brauch
Aromatase inhibitor (AI) resistance during breast cancer treatment is mimicked by MCF-7:5C (5C) and MCF-7:2A (2A) cell lines that grow spontaneously. Survival signaling is reconfigured but cells are vulnerable to estradiol (E2)-inducible apoptosis. These model systems have alterations of stress related pathways including the accumulation of endoplasmic reticulum, oxidative, and inflammatory stress that occur prior to E2-induced apoptosis. We investigated miRNA expression profiles of 5C and 2A to characterize their AI resistance phenotypes...
September 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27638711/carotenoids-biochemistry-pharmacology-and-treatment
#14
Alireza Milani, Marzieh Basirnejad, Sepideh Shahbazi, Azam Bolhassani
Carotenoids and retinoids have several similarities in biological activities such as antioxidant properties, the inhibition of malignant tumor growth, and the induction of apoptosis. Supplementation with carotenoids can influence cell growth regulation, and modulate gene expression and immune response. Epidemiologic studies have shown the correlation of high carotenoid intake from food sources with reduced risk of breast, cervical, ovarian, colorectal cancers, and cardiovascular or eye diseases. Cancer chemoprevention by dietary carotenoids involves some approaches including gap junctional intercellular communication (GJIC), growth factor signaling, cell cycle progression, differentiation-related proteins, retinoid-like receptors, antioxidant response element, nuclear receptors, AP-1 transcriptional complex, Wnt/β-Catenin pathway, and inflammatory cytokines...
September 16, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27566201/amyrsinol-diterpene-isolated-from-a-traditional-herbal-medicine-langdu-reverses-multidrug-resistance-in-breast-cancer-cells
#15
Huapeng Wang, Xiaobo Chen, Ting Li, Jing Xu, Yonggang Ma
ETHNOPHARMACOLOGICAL RELEVANCE: LANGDU, a Chinese traditional herbal medicine, was the dried roots of Euphorbia prolifera Buch-Ham. The herbal medicine has been used as anti-cancer and anti-inflammatory drug in local folk medicine for several hundred years. AIM OF THE STUDY: P-glycoprotein (P-gp) is a transmembrane exporter, which can expel a variety of anti-cancer drugs. Over-expressed P-glycoprotein in cancer cells impairs the effect of cancer chemotherapy and results in multidrug resistance (MDR)...
August 23, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27554339/adam9-silencing-inhibits-breast-tumor-cells-transmigration-through-blood-and-lymphatic-endothelial-cells
#16
Kelli Cristina Micocci, Milene Nóbrega de Oliveira Moritz, Rafael Luis Bressani Lino, Laila Ribeiro Fernandes, Antonio Gilclêr Ferreira Lima, Camila Castro Figueiredo, Verônica Morandi, Heloisa Sobreiro Selistre-de-Araujo
ADAMs are transmembrane multifunctional proteins that contain disintegrin and metalloprotease domains. ADAMs act in a diverse set of biological processes, including fertilization, inflammatory responses, myogenesis, cell migration, cell proliferation and ectodomain cleavage of membrane proteins. These proteins also have additional functions in pathological processes as cancer and metastasis development. ADAM9 is a member of ADAM protein family that is overexpressed in several types of human carcinomas. The aim of this study was to investigate the role of ADAM9 in hematogenous and lymphatic tumor cell dissemination assisting the development of new therapeutic tools...
September 2016: Biochimie
https://www.readbyqxmd.com/read/27550449/interleukin-30-promotes-breast-cancer-growth-and-progression
#17
Irma Airoldi, Claudia Cocco, Carlo Sorrentino, Domenico Angelucci, Serena Di Meo, Lamberto Manzoli, Silvia Esposito, Domenico Ribatti, Maria Bertolotto, Laura Iezzi, Clara Natoli, Emma Di Carlo
The inflammatory tissue microenvironment which promotes the development of breast cancer (BRCA) is not fully understood. Here we report a role for elevated IL-30 in supporting the BRCA cell viability and invasive migration. IL-30 was absent in normal mammary ducts, ductules and acini of histologically normal breast and scanty in the few stromal infiltrating leukocytes. In contrast, its IL-30 was expressed frequently in BRCA specimens where it was associated with triple-negative and HER2+ molecular subtypes...
August 22, 2016: Cancer Research
https://www.readbyqxmd.com/read/27497816/inhibition-of-hif-1%C3%AE-enhances-anti-tumor-effects-of-dendritic-cell-based-vaccination-in-a-mouse-model-of-breast-cancer
#18
Nasim Kheshtchin, Samaneh Arab, Maryam Ajami, Reza Mirzaei, Mahboubeh Ashourpour, Neda Mousavi, Najmeh Khosravianfar, Farhad Jadidi-Niaragh, Afshin Namdar, Farshid Noorbakhsh, Jamshid Hadjati
Considerable evidence shows that the tumor microenvironment is an active participant in preventing immunosurveillance and limiting the efficacy of anticancer therapies. Hypoxia is a prominent characteristic of the solid tumor microenvironment. The transcription factor hypoxia-inducible factor-1α (HIF-1α) is an important mediator of hypoxic response of tumor cells that modulates the expression of specific genes involved in tumor immunosuppression. Using a 4T1 breast cancer model, we show that in vivo administration of PX-478, an inhibitor of oxygen-sensitive HIF-1α, led to reduced expression of Foxp3 and VEGF transcript and/or protein, molecules that are directly controlled by HIF-1...
October 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27490685/biomarkers-for-presymptomatic-doxorubicin-induced-cardiotoxicity-in-breast-cancer-patients
#19
Valentina K Todorova, Issam Makhoul, Eric R Siegel, Jeanne Wei, Annjanette Stone, Weleetka Carter, Marjorie L Beggs, Aaron Owen, V Suzanne Klimberg
Cardiotoxicity of doxorubicin (DOX) remains an important health concern. DOX cardiotoxicity is cumulative-dose-dependent and begins with the first dose of chemotherapy. No biomarker for presymptomatic detection of DOX cardiotoxicity has been validated. Our hypothesis is that peripheral blood cells (PBC) gene expression induced by the early doses of DOX-based chemotherapy could identify potential biomarkers for presymptomatic cardiotoxicity in cancer patients. PBC gene expression of 33 breast cancer patients was conducted before and after the first cycle of DOX-based chemotherapy...
2016: PloS One
https://www.readbyqxmd.com/read/27470349/3b-a-novel-photosensitizer-inhibits-glycolysis-and-inflammation-via-mir-155-5p-and-breaks-the-jak-stat3-socs1-feedback-loop-in-human-breast-cancer-cells
#20
Kecheng Lei, Wenpei Du, Shengchao Lin, Liyan Yang, Yichun Xu, Yuwei Gao, Baixue Xu, Shaoying Tan, Yufang Xu, Xuhong Qian, Xin Liang, Jianwen Liu
Compared to normal cells, most cancer cells produce ATP by glycolysis under aerobic conditions rather than via the tricarboxylic acid cycle (TCA). This study is intended to determine whether 3B, a novel photosensitizer, can inhibit glycolysis and inflammation in breast cancer cells. We showed that 3B had the ability to repress glucose consumption as well as the generation of ATP, lactate and lactate dehydrogenase. 3B-PDT not only inhibited the expression of IL-1β and IL-6 but also affected the JAK-STAT3 inflammatory pathway in vitro...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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