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https://www.readbyqxmd.com/read/28942553/clinacanthus-nutans-mitigates-neuronal-apoptosis-and-ischemic-brain-damage-through-augmenting-the-c-ebp%C3%AE-driven-ppar-%C3%AE-transcription
#1
Jui-Sheng Wu, Mei-Han Kao, Hsin-Da Tsai, Wai-Mui Cheung, Jin-Jer Chen, Wei-Yi Ong, Grace Y Sun, Teng-Nan Lin
Clinacanthus nutans Lindau (C. nutans) is a traditional herbal medicine widely used in Asian countries for treating a number of remedies including snake and insect bites, skin rashes, viral infections, and cancer. However, the underlying molecular mechanisms for its action and whether C. nutans can offer protection on stroke damage in brain remain largely unknown. In the present study, we demonstrated protective effects of C. nutans extract to ameliorate neuronal apoptotic death in the oxygen-glucose deprivation model and to reduce infarction and mitigate functional deficits in the middle cerebral artery occlusion model, either administered before or after hypoxic/ischemic insult...
September 23, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28911137/cardiovascular-diseases-and-life-expectancy-in-adults-with-type-2-diabetes-a-korean-national-sample-cohort-study
#2
Yu Mi Kang, Yun Kyung Cho, Seung Eun Lee, Joong-Yeol Park, Woo Je Lee, Ye-Jee Kim, Chang Hee Jung
Objective: Although type 2 diabetes is a strong risk factor for cardiovascular disease and mortality, information on its association with mortality and life expectancy according to cardiovascular comorbidities is limited, especially in Asia. Thus, this study assessed mortality and reductions in life expectancy associated with cardiometabolic multimorbidity. Design and Methods: A total of 569,831 participants older than 30 years from Korean National Health Insurance Service-National Sample Cohort were enrolled between 2002 and 2006 and followed for a median of 12...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28890012/ethnicity-race-and-post-operative-stroke-risk-among-53-593-patients-with-asymptomatic-carotid-stenosis-undergoing-revascularization
#3
Roxanna M Garcia, Seungwon Yoon, Tene Cage, Matthew B Potts, Michael T Lawton
BACKGROUND: The incidence of post-operative stroke following carotid endarterectomy is an uncommon event and differences by racial and ethnic subgroups are not fully described in the literature. OBJECTIVE: To investigate the impact of race and ethnicity on post-operative stroke risk among patients with asymptomatic carotid stenosis undergoing carotid endarterectomy. METHODS: The ACS-NSQIP database between 2008 and 2015 was used to identify patients undergoing carotid endarterectomy with no stroke history...
September 7, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28883227/utilization-of-anticoagulant-and-antiplatelet-agents-among-patients-with-atrial-fibrillation-undergoing-percutaneous-coronary-intervention%C3%A3-retrospective-cohort-study-using-a-nationwide-claims-database-in-japan
#4
Fumiko Ono, Shiro Tanaka, Yoko M Nakao, Koji Kawakami
BACKGROUND: The European Society of Cardiology recommends a risk-based antithrombotic strategy for patients with atrial fibrillation (AF) who undergo percutaneous coronary intervention (PCI) based on CHA2DS2-VASc and HAS-BLED scores. However, because it is unclear if that strategy can be generalized to Asians, we aimed to describe antithrombotic therapies among Japanese patients.Methods and Results:Using a nationwide claims database in Japan, this retrospective cohort study identified AF patients who underwent PCI from April 1, 2014 to March 31, 2015...
September 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28837736/prevalence-and-associations-of-retinal-emboli-with-ethnicity-stroke-and-renal-disease-in-a-multiethnic-asian-population-the-singapore-epidemiology-of-eye-disease-study
#5
Ning Cheung, Kelvin Teo, Wanting Zhao, Jie Jin Wang, Kumari Neelam, Nicholas Y Q Tan, Paul Mitchell, Ching-Yu Cheng, Tien Yin Wong
Importance: To our knowledge, population-based data on retinal emboli are limited in Asia. Besides its associations with traditional cardiovascular risk factors and stroke, associations between retinal emboli and renal disease and function remain unclear. Objective: To examine the prevalence of and risk factors for retinal emboli in a large, contemporary, multiethnic Asian population. Design, Setting, and Participants: This population-based cross-sectional study was conducted from 2004 to 2011 and included a total of 10 033 Chinese, Malay, and Indian persons aged 40 to 80 years residing in the general communities of Singapore...
August 24, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28834205/role-of-ambulatory-blood-pressure-monitoring-for-the-management-of-hypertension-in-asian-populations
#6
REVIEW
Satoshi Hoshide, Hao-Min Cheng, Qifang Huang, Sungha Park, Chang-Gyu Park, Chen-Huan Chen, Ji-Gwang Wang, Kazuomi Kario
Out-of-clinic blood pressure (BP) measurement, eg, ambulatory BP monitoring, has a strong association with target organ damage and is a powerful predictor of cardiovascular events compared with clinic BP measurement. Ambulatory BP monitoring can detect masked hypertension or various BP parameters in addition to average 24-hour BP level. Short-term BP variability assessed by standard deviation or average real variability, diminished nocturnal BP fall, nocturnal hypertension, and morning BP surge assessed by ambulatory BP monitoring have all been associated with target organ damage and cardiovascular prognosis...
August 22, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28793375/independent-predictors-of-medication-adherence-among-singaporean-patients-following-an-ischemic-stroke-or-transient-ischemic-attack
#7
Wenru Wang, Gerk Sin Chia, Il Fan Tan, Siew Noi Janis Tye, Xiaona Wang, Birong Zhu, Ying Jiang
OBJECTIVES: To investigate the independent predictors of medication adherence among Singaporean patients following an ischemic stroke or transient ischemic attack. BACKGROUND: Secondary prevention of stroke includes optimal control over modifiable risk factors, and medication adherence is important in controlling the effect of co-morbidities. However, there is a paucity of published literature on the topics of medication adherence among stroke patients, especially in the Asian population...
August 9, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28768848/predicting-major-bleeding-in-patients-with-noncardioembolic-stroke-on-antiplatelets-s2top-bleed
#8
Nina A Hilkens, Ale Algra, Hans-Christoph Diener, Johannes B Reitsma, Philip M Bath, Laszlo Csiba, Werner Hacke, L Jaap Kappelle, Peter J Koudstaal, Didier Leys, Jean-Louis Mas, Ralph L Sacco, Pierre Amarenco, Leila Sissani, Jacoba P Greving
OBJECTIVE: To develop and externally validate a prediction model for major bleeding in patients with a TIA or ischemic stroke on antiplatelet agents. METHODS: We combined individual patient data from 6 randomized clinical trials (CAPRIE, ESPS-2, MATCH, CHARISMA, ESPRIT, and PRoFESS) investigating antiplatelet therapy after TIA or ischemic stroke. Cox regression analyses stratified by trial were performed to study the association between predictors and major bleeding...
August 29, 2017: Neurology
https://www.readbyqxmd.com/read/28765771/2017-consensus-of-the-asia-pacific-heart-rhythm-society-on-stroke-prevention-in-atrial-fibrillation
#9
Chern-En Chiang, Ken Okumura, Shu Zhang, Tze-Fan Chao, Chung-Wah Siu, Toon Wei Lim, Anil Saxena, Yoshihide Takahashi, Wee Siong Teo
Atrial fibrillation (AF) is the most common sustained arrhythmia, causing a 2-fold increase in mortality and a 5-fold increase in stroke. The Asian population is rapidly aging, and in 2050, the estimated population with AF will reach 72 million, of whom 2.9 million may suffer from AF-associated stroke. Therefore, stroke prevention in AF is an urgent issue in Asia. Many innovative advances in the management of AF-associated stroke have emerged recently, including new scoring systems for predicting stroke and bleeding risks, the development of non-vitamin K antagonist oral anticoagulants (NOACs), knowledge of their special benefits in Asians, and new techniques...
August 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28662192/the-risk-of-intravenous-thrombolysis-induced-intracranial-hemorrhage-in-taiwanese-patients-with-unruptured-intracranial-aneurysm
#10
Wei Ting Chiu, Chien Tai Hong, Nai Fang Chi, Chaur Jong Hu, Han Hwa Hu, Lung Chan
BACKGROUND: The presence of an intracranial aneurysm is contraindicated to recombinant tissue plasminogen activator (r-tPA) treatment for acute ischemic stroke. However, it is difficult to exclude asymptomatic intracranial aneurysms by using conventional, noncontrast head computed tomography (CT), which is the only neuroimaging suggested before r-tPA. Recent case reports and series have shown that administering r-tPA to patients with a pre-existing aneurysm does not increase the bleeding risk...
2017: PloS One
https://www.readbyqxmd.com/read/28648960/effect-of-cholesteryl-ester-transfer-protein-gene-taqib-polymorphism-on-the-risk-of-ischemic-stroke-a-meta-analysis
#11
Dan-Dan Yu, Qiong-Qiong Ren, Bao Dong, Dong-Dong Zhao, Ye-Huan Sun
BACKGROUND: The association between cholesteryl ester transfer protein (CETP) TaqIB polymorphism and ischemic stroke (IS) risk has generated conflicting results. To investigate whether the TaqIB polymorphism of the CETP gene was associated with the risk of IS, a meta-analysis was performed. METHODS: Studies were retrieved by searching PubMed, Web of Science, the Chinese National Knowledge Infrastructure, the Chinese Wanfang Database, and the Chinese VIP Database before January 16, 2017...
October 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28648320/cost-effectiveness-of-edoxaban-vs-warfarin-in-patients-with-atrial-fibrillation-based-on-results-of-the-engage-af-timi-48-trial-taiwanese-perspective
#12
Katherine A Vilain, Ming Chin Yang, Elise Chia Hui Tan, Kaijun Wang, Haiyan Li, Wan Hsuan Hsu, Robert P Giugliano, David J Cohen, Elizabeth A Magnuson
BACKGROUND: Novel anticoagulants, such as factor Xa inhibitors, have entered clinical practice as alternatives to warfarin for the prevention of stroke and systemic embolic event (SEE) in patients with atrial fibrillation (AF). It is not known whether edoxaban, the fourth-to-market factor Xa inhibitor approved for this indication, will be cost-effective in Taiwan, where the cost of warfarin monitoring is prohibitive. METHODS: A Markov model projecting lifetime results of edoxaban 60 mg/30 mg dose-reduced versus warfarin in patients with nonvalvular AF, based on the ENGAGE AF - TIMI 48 trial, found edoxaban to be of high value relative to warfarin, from the perspective of the US health care system...
May 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/28637778/breastfeeding-and-the-risk-of-maternal-cardiovascular-disease-a-prospective-study-of-300%C3%A2-000-chinese-women
#13
Sanne A E Peters, Ling Yang, Yu Guo, Yiping Chen, Zheng Bian, Jianwei Du, Jie Yang, Shanpeng Li, Liming Li, Mark Woodward, Zhengming Chen
BACKGROUND: Breastfeeding confers substantial benefits to child health and has also been associated with lower risk of maternal cardiovascular diseases (CVDs) in later life. However, the evidence on the effects of CVD is still inconsistent, especially in East Asians, in whom the frequency and duration of breastfeeding significantly differ from those in the West. METHODS AND RESULTS: In 2004-2008, the nationwide China Kadoorie Biobank recruited 0.5 million individuals aged 30 to 79 years from 10 diverse regions across China...
June 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28592782/family-history-and-stroke-risk-in-china-evidence-from-a-large-cohort-study
#14
Tian Tian, Guangfu Jin, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Hongbing Shen, Zhengming Chen, Zhibin Hu, Liming Li
BACKGROUND AND PURPOSE: Large cohort studies on relationship between family history of stroke (FHS) and stroke risk are lacking in Asians. We aimed to systematically evaluate the association of FHS with stroke risk in a cohort study of 0.5 million Chinese adults. METHODS: Information about FHS was self-reported. The median follow-up time was 7.16 years and the end-point of follow-up was incident stroke, which was entered directly into the China Kadoorie Biobank system...
May 2017: Journal of Stroke
https://www.readbyqxmd.com/read/28584003/daily-total-physical-activity-and-incident-stroke-the-japan-public-health-center-based-prospective-study
#15
Yasuhiko Kubota, Hiroyasu Iso, Kazumasa Yamagishi, Norie Sawada, Shoichiro Tsugane
BACKGROUND AND PURPOSE: There is limited evidence on the association between total physical activity and stroke in Asian populations experiencing a greater burden of hemorrhagic stroke than Western populations. We aimed to understand their optimal level of physical activity for stroke prevention. METHODS: A total of 74 913 Japanese people 50 to 79 years of age without histories of cardiovascular disease or cancer were followed from 2000 to 2012. RESULTS: During the 698 946 person-years of follow-up, we documented a total of 2738 incident cases of stroke, including 1007 hemorrhagic strokes (747 intraparenchymal and 260 subarachnoid hemorrhages) and 1721 ischemic strokes (1206 nonembolic and 515 embolic infarctions)...
July 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28579510/an-examination-of-stroke-risk-and-burden-in-south-asians
#16
Vineeta Singh, Shyam Prabhakaran, Seemant Chaturvedi, Aneesh Singhal, Jeyaraj Pandian
BACKGROUND: South Asians (India, Pakistan, Sri Lanka, Bangladesh, Nepal, and Bhutan) are at a disproportionately higher risk of stroke and heart disease due to their cardiometabolic profile. Despite evidence for a strong association between diabetes and stroke, and growing stroke risk in this ethnic minority-notwithstanding reports of higher stroke mortality irrespective of country of residence-the explanation for the excess risk of stroke remains unknown. METHODS: We have used extensive literature review, epidemiologic studies, morbidity and mortality records, and expert opinions to examine the burden of stroke among South Asians, and the risk factors identified thus far...
October 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28579508/decompressive-hemicraniectomy-for-malignant-middle-cerebral-artery-stroke-south-asian-experience
#17
Saadat Kamran, Naveed Akhtar, Abdul Salam, Ayman Alboudi, Hiba Rashid, Kainat Kamran, Rabia Ali Khan, Mohsin Khalid Mirza, Arsalan Ahmed, Ahmed M A Own, Sohail Al Rukun, Jihad Inshasi, Dirk Deleu, Ghanim Al Sulaiti, Ashfaq Shuaib
BACKGROUND: The randomized trials showed improved outcome and reduced mortality in malignant middle cerebral artery (MMCA) undergoing Decompressive hemicraniectomy (DHC) within 48 hours of stroke onset. Despite high prevalence of stroke, especially in younger individuals, high and short-term mortality from stroke in South Asian and Middle East, there is little published data on DHC in patients with MMCA stroke. METHODS: This is a retrospective, multicenter cross-sectional study to measure outcome following DHC using the modified Rankin Scale (mRS) and dichotomized as favorable (mRS ≤ 4) or unfavorable (mRS > 4), at 3 months...
October 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28568968/effect-of-known-history-of-heart-disease-on-survival-outcomes-after-out-of-hospital-cardiac-arrests
#18
Magdalene Hm Lee, Stephanie Fook-Chong, Win Wah, Sang Do Shin, Tatsuya Nishiuchi, Patrick Chow-In Ko, Ghulam Yasin Naroo, Kwanhathai Darin Wong, Ling Tiah, Apichaya Monsomboon, Fahad J Siddiqui, Marcus Eh Ong
OBJECTIVE: We aimed to investigate the effect of known heart disease on post-out-of-hospital cardiac arrest (OHCA) survival outcomes, and its association with factors influencing survival. METHODS: This was an observational, retrospective study involving an OHCA database from seven Asian countries in 2009-2012. Heart disease was defined as a documented diagnosis of coronary artery disease or congenital heart disease. Patients with non-traumatic arrests for whom resuscitation was attempted and with known medical histories were included...
May 31, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28482349/genomics-of-cardiometabolic-disorders-in-sub-saharan-africa
#19
Sally N Adebamowo, Fasil Tekola-Ayele, Adebowale A Adeyemo, Charles N Rotimi
Sub-Saharan Africa (SSA) is experiencing a growing burden of cardiometabolic disorders, including diabetes, dyslipidemia, hypertension, obesity, coronary heart disease, and stroke. The increasing trends are expected to accelerate as SSA continues to experience economic progress, population growth, and the shift from communicable to noncommunicable diseases. These complex disorders are caused by multiple, potentially interacting, environmental, and genetic factors. While considerable progress has been made in the identification of the sociocultural, demographic, and lifestyle risk factors for cardiometabolic disorders, many genetic factors that underlie individual susceptibility to these diseases remain largely unknown...
2017: Public Health Genomics
https://www.readbyqxmd.com/read/28461125/modulation-of-neurogenesis-via-neurotrophic-factors-in-acupuncture-treatments-for-neurological-diseases
#20
REVIEW
Hwa Kyoung Shin, Sae-Won Lee, Byung Tae Choi
Acupuncture is one of the main healing arts in Oriental medicine. It has long been used in East Asian countries, including Korea and China, and is thought to be an effective alternative treatment for various neurological diseases. The therapeutic effects of acupuncture come from inserting a needle at specific acupoints on the body surface, with subsequent delivery of stimulation via manual rotation or electric pulses (electroacupuncture, EA). In various neurological disease models, peripheral nerve stimulation using acupuncture or EA may have protective effects on neural tissues by increasing expression of neurotrophic factors (NTFs), such as brain-derived neurotrophic factor and glial-derived neurotrophic factor, in the central nervous system, especially the brain...
April 29, 2017: Biochemical Pharmacology
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