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vancomycin trough

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https://www.readbyqxmd.com/read/28709394/intravenous-vancomycin-is-associated-with-the-development-of-nephrotoxicity-in-patients-with-class-iii-obesity
#1
Yookyung Christy Choi, Stephen Saw, Daniel Soliman, Angela L Bingham, Laura Pontiggia, Krystal Hunter, Linda Chuang, Laura A Siemianowski, Benjamin Ereshefsky, James M Hollands
BACKGROUND: A consensus statement recommends initial intravenous (IV) vancomycin dosing of 15-20 mg/kg every 8- 24 hours, with an optional 25- to 30-mg/kg loading dose. Although some studies have shown an association between weight and the development of vancomycin-associated nephrotoxicity, results have been inconsistent. OBJECTIVE: To evaluate the correlation between incidence of nephrotoxicity associated with weight-based IV vancomycin dosing strategies in nonobese and obese patients...
July 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28699888/predicting-augmented-renal-clearance-using-estimated-glomerular-filtration-rate-in-critically-ill-children%C3%A2
#2
Bongjin Lee, Jongyoon Kim, June Dong Park, Hyun Mi Kang, Yoon Sook Cho, Kwi Suk Kim
AIMS: Measured glomerular filtration rate (mGFR) is often used to identify augmented renal clearance (ARC). However, in the clinical setting, estimated GFR (eGFR) is obtained more quickly and inexpensively. We aimed to determine whether eGFR can identify ARC by evaluating the correlation between the eGFR and vancomycin trough level (VTL). MATERIALS AND METHODS: We retrospectively reviewed the records of patients aged ≤ 18 years who underwent vancomycin therapeutic drug monitoring at our tertiary hospital from July 2009 to June 2014...
July 12, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28690700/effects-of-staff-education-and-standardizing-dosing-and-collection-times-on-vancomycin-trough-appropriateness-in-ward-patients
#3
Drayton A Hammond, Lexis N Atkinson, Taylor B James, Jacob T Painter, Katherine Lusardi
BACKGROUND: Many institutions have guidelines for initiation and monitoring, but not timing, of vancomycin. OBJECTIVE: Our objective was to evaluate vancomycin trough collection appropriateness before and after an initiative to change the dosing and trough collection times in ward patients. METHODS: A retrospective cohort study of ward patients from May 2014-16 who received scheduled intravenous vancomycin was performed. Nurse managers and pharmacists provided staff education...
April 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28690689/vancomycin-use-dosing-and-serum-trough-concentrations-in-the-pediatric-population-a-retrospective-institutional-review
#4
Kevin Rajon, Regis Vaillancourt, Nisha Varughese, Gilda Villarreal
BACKGROUND: Vancomycin is used primarily for Gram-positive infections. Recommended dosage regimens and targeted therapeutic levels vary between institutions. OBJECTIVES: This study aims to describe therapeutic levels according to initial vancomycin doses and patient's age. A secondary objective was to evaluate appropriateness of vancomycin use in our hospital. METHODS: A retrospective chart review was conducted at the Children's Hospital of Eastern Ontario...
April 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28655381/evaluation-of-factors-associated-with-the-achievement-of-an-optimal-teicoplanin-trough-concentration%C3%A2
#5
Kenshi Takechi, Hiroaki Yanagawa, Yoshito Zamami, Keisuke Ishizawa, Akihiro Tanaka, Hiroaki Araki
OBJECTIVE: Because teicoplanin has a long serum half-life, a longer period of time is needed to achieve a steady-state concentration compared with vancomycin. The administration of an initial loading dose has been recommended to reach an effective teicoplanin serum concentration for the treatment of methicillin-resistant Staphylococcus aureus (MRSA). However, little is known regarding factors that affect teicoplanin concentration. This study aimed to retrospectively determine which factors are associated with achieving an optimal teicoplanin trough level...
June 28, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28650363/population-pharmacokinetics-and-pharmacodynamic-target-attainment-of-vancomycin-in-neonates-on-extracorporeal-life-support
#6
Jeffrey J Cies, Wayne S Moore, Kristen Nichols, Chad A Knoderer, Dominick M Carella, Arun Chopra
OBJECTIVES: To evaluate the population pharmacokinetics and pharmacodynamic target attainment of vancomycin in neonates with a contemporary ¼-inch extracorporeal life support circuit with a Quadrox-iD Pediatric oxygenator (Maquet Cardiovascular, LLC, Wayne, NJ). DESIGN: Retrospective medical record review. SETTING: Two free-standing tertiary/quaternary pediatric children's hospitals. PATIENTS: Neonates receiving either veno-arterial or veno-venous extracorporeal life support and vancomycin for empiric or definitive therapy with resulting serum concentrations...
June 22, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28640009/augmented-renal-clearance-using-population-based-pharmacokinetic-modeling-in-critically-ill-pediatric-patients
#7
Sean N Avedissian, Erin Bradley, Diana Zhang, John S Bradley, Lama H Nazer, Tri M Tran, Austin Nguyen, Jennifer Le
OBJECTIVES: The objectives of this study were to: 1) evaluate the prevalence of augmented renal clearance in critically ill pediatric patients using vancomycin clearance; 2) derive the pharmacokinetic model that best describes vancomycin clearance in critically ill pediatric patients; and 3) correlate vancomycin clearance with creatinine clearance estimated by modified Schwartz or Cockcroft-Gault. DESIGN: Retrospective, two-center, cohort study from 2003 to 2016...
June 20, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28627271/vancomycin-trough-concentration-poorly-characterizes-auc-is-it-time-to-transition-to-auc-based-vancomycin-monitoring
#8
Robert W Seabury, Andrew M Stoessel, Jeffrey M Steele
No abstract text is available yet for this article.
June 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28625235/-pharmacokinetics-of-vancomycin-in-patients-with-severe-acute-pancreatitis-and-its-influencing-factors-analysis-of-7-years-data
#9
Juan He, Enqiang Mao, Feng Jing, Huiting Jiang, Wanhua Yang, Erzhen Chen
OBJECTIVE: To observe the change of the serum trough concentration and its pharmacokinetics of vancomycin in patients with severe acute pancreatitis (SAP), and to analyze the factors influencing vancomycin concentration. METHODS: A retrospective analysis was conducted. Steady-state trough concentrations of vancomycin from patients (18-80 years old) with SAP concomitantly with G(+) infection admitted to Intensive Care Unit (ICU) of Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine from January 2010 to December 2016 were enrolled...
June 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28607023/pharmacokinetic-assessment-of-vancomycin-loading-dose-in-critically-ill-patients
#10
Osvaldo Álvarez, Jose Cristian Plaza-Plaza, Manuel Ramirez, Alexis Peralta, Cristián A Amador, Roberto Amador
Background: The vancomycin loading dose (LD) of 25-30 mg/kg is a frequently practiced strategy to achieve effective concentrations from the first-treatment dose. However, considering only the body weight for dosing might be inadequate in critically ill patients due to pharmacokinetics changes.Objective: Assess achieving optimal trough serum levels of vancomycin and AUC0-24/MIC in the first 24-hours of treatment, by using a LD based on population pharmacokinetic parameters of critically ill patients.Methods: We performed a concurrent cohort study over 22 months of patients with severe sepsis who received intravenous vancomycin...
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28573434/the-whole-price-of-vancomycin-toxicities-troughs-and-time
#11
Meghan N Jeffres
Vancomycin is a glycopeptide antibiotic that is active against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. Nephrotoxicity, which is usually reversible, is the most serious common adverse effect of vancomycin. Vancomycin-associated nephrotoxicity prolongs hospital stays, imposes a need for additional antibiotics and, in rare circumstances, dialysis treatment, and increases medical costs and mortality. Risk factors for nephrotoxicity include the dose and duration of vancomycin treatment, serum trough concentration, patient characteristics, and concomitant receipt of nephrotoxins...
July 2017: Drugs
https://www.readbyqxmd.com/read/28562284/epidemiology-of-methicillin-resistant-staphylococcus-aureus-bacteremia-in-children
#12
Rana F Hamdy, Alice J Hsu, Chris Stockmann, Jared A Olson, Matthew Bryan, Adam L Hersh, Pranita D Tamma, Jeffrey S Gerber
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with high rates of treatment failure in adults. The epidemiology, clinical outcomes, and risk factors for treatment failure associated with MRSA bacteremia in children are poorly understood. METHODS: Multicenter, retrospective cohort study of children ≤18 years hospitalized with MRSA bacteremia across 3 tertiary care children's hospitals from 2007 to 2014. Treatment failure was defined as persistent bacteremia >3 days, recurrence of bacteremia within 30 days, or attributable 30-day mortality...
May 5, 2017: Pediatrics
https://www.readbyqxmd.com/read/28562258/the-impact-of-pediatric-specific-vancomycin-dosing-guidelines-a-quality-improvement-initiative
#13
Molly Miloslavsky, Marjorie F Galler, Iman Moawad, Janet Actis, Brian M Cummings, Chadi M El Saleeby
BACKGROUND AND OBJECTIVES: There are limited data guiding vancomycin dosing practices in the pediatric population to target the goal troughs recommended by national vancomycin guidelines. In this study, we sought to improve adherence to guideline trough targets through a quality improvement intervention. METHODS: A retrospective analysis was first conducted to assess baseline performance. A multidisciplinary team then developed and implemented a standardized dosing algorithm recommending 15 mg/kg per dose for mild and moderate infections (goal trough: 10-15 µg/mL) and 20 mg/kg per dose for severe infections (goal trough: 15-20 µg/mL), both delivered every 6 hours (maximum single dose: 750 mg)...
May 11, 2017: Pediatrics
https://www.readbyqxmd.com/read/28544476/usefulness-of-a-decision-tree-model-for-the-analysis-of-adverse-drug-reactions-evaluation-of-a-risk-prediction-model-of-vancomycin-associated-nephrotoxicity-constructed-using-a-data-mining-procedure
#14
Shungo Imai, Takehiro Yamada, Kumiko Kasashi, Masaki Kobayashi, Ken Iseki
OBJECTIVES: Several publications concerning decision tree (DT) analysis in medical fields have recently demonstrated its usefulness for defining prognostic factors in various diseases. However, there are minimal reports on the predictors of adverse drug reactions. We attempted to use DT analysis to discover combinations of multiple risk factors that would increase the risk of nephrotoxicity associated with vancomycin (VCM). To demonstrate the usefulness of DT analysis, we compared its predictive performance with that of multiple logistic regression analysis...
May 23, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28532398/clinical-outcomes-of-linezolid-and-vancomycin-in-patients-with-nosocomial-pneumonia-caused-by-methicillin-resistant-staphylococcus-aureus-stratified-by-baseline-renal-function-a-retrospective-cohort-analysis
#15
Ping Liu, Blair Capitano, Amy Stein, Ali A El-Solh
BACKGROUND: The primary objective of this study is to assess whether baseline renal function impacts treatment outcomes of linezolid and vancomycin (with a dose-optimized regimen) for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. METHODS: We conducted a retrospective cohort analysis of data generated from a prospective, randomized, controlled clinical trial (NCT 00084266). The analysis included 405 patients with culture-proven MRSA pneumonia. Baseline renal function was stratified based on creatinine clearance...
May 22, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28530212/-measurements-of-vancomycin-concentrations-in-the-blood-a-method-of-personalization-the-antibiotic-therapy-in-patients-with-chronic-kidney-disease
#16
Joanna Pondel, Piotr Krajewski, Natalia Królikowska, Aleksandra Tobiasz, Hanna Augustyniak-Bartosik, Magdalena Hurkacz
Therapeutic Drug Monitoring is a recognized method of personalizing treatment, having particular application in patients with chronic kidney disease who have frequent infections, requiring administration of vancomycin. International guidelines indicate the need to adjust the dose of the drug to the state of renal function. The recommended therapeutic ranges of minimum and maximum levels should be achieved in order to increase the effectiveness and safety of treatment. AIM: The aim of this study was to evaluate the usefulness of measuring the concentration of vancomycin in patients with chronic kidney disease due to bacterial infection...
April 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28522643/allometric-versus-consensus-guideline-dosing-in-achieving-target-vancomycin-trough-concentrations
#17
Matthew L Brown, Amber M Hutchison, Aaron M McAtee, Philippe R Gaillard, Darrell T Childress
PURPOSE: Results of a study comparing the performance of allometric versus consensus guideline-recommended vancomycin dosing in achieving initial trough concentrations within the desired range are reported. METHODS: A retrospective study was conducted to compare selected outcomes with 2 vancomycin dosing methods: (1) dosing by total body weight, as recommended in current consensus guidelines, and (2) a new empirical vancomycin dosing strategy grounded in allometry (the study of the relationship between body size and physiology)...
May 18, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28515506/impact-of-pharmacy-practice-model-expansion-on-pharmacokinetic-services-optimization-of-vancomycin-dosing-and-improved-patient-safety
#18
Zhe Han, Natasha N Pettit, Emily M Landon, Benjamin D Brielmaier
Background: The impact of pharmacy interventions on optimizing vancomycin therapy has been described, however interventions vary among studies and the most optimal pharmacy practice model (PPM) for pharmacokinetic (PK) services has not been established. Objective: The purpose of this study is to demonstrate the value of 24 hours a day, 7 days a week (24/7) PK services. Methods: New PK services were implemented in 2 phases with institutional PPM expansion. Phase 1 included universal monitoring by pharmacists with recommendations made to prescribers during business hours...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28490050/is-trough-concentration-of-vancomycin-predictive-of-the-area-under-the-curve-a-commentary
#19
Anna-Karin Hamberg, Ron Keizer
No abstract text is available yet for this article.
June 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28457752/evaluation-of-the-variability-and-safety-of-serum-trough-concentrations-of-vancomycin-in-patients-admitted-to-the-intensive-care-unit
#20
Xiaodan Qian, Guantao Du, Chunmei Weng, Haijun Zhou, Xianju Zhou
OBJECTIVE: To examine the variability and safety of serum trough concentrations of vancomycin in patients admitted to the intensive care unit (ICU) and to analyze the factors influencing the trough concentration. METHODS: Data were collected retrospectively from ICU patients receiving vancomycin treatment at a fixed dose of 2g/day due to unobtainable weight data, at Changzhou No. 2 People's Hospital, between 2012 and 2015. Vancomycin trough concentrations were compared between groups stratified by sex, age, and estimated glomerular filtration rate (eGFR)...
July 2017: International Journal of Infectious Diseases: IJID
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