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vancomycin trough

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https://www.readbyqxmd.com/read/29764549/-clinical-verification-of-vancomycin-population-pharmacokinetics-in-patients-with-augmented-renal-clearance
#1
Haodi Lu, Lian Tang, Shengmin Xue, Zhiwei Zhuang, Jie Fang, Fuli Zhao, Erning Shang
OBJECTIVE: To evaluate the predictive value and to verify the clinical effect of JPKD-vancomycin for the trough concentration of vancomycin in patients with augmented renal clearance (ARC), and to provide a reference for clinical individualized drug therapy. METHODS: A retrospective analysis was conducted. The clinical data of 48 adult patients with ARC using vancomycin and monitoring steady-state trough concentration of vancomycin admitted to Suzhou Hospital Affiliated to Nanjing Medical University from July 2013 to July 2017 were collected...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29761071/long-term-conventionally-dosed-vancomycin-therapy-in-patients-with-orthopaedic-implant-related-infections-seems-as-effective-and-safe-as-long-term-penicillin-or-clindamycin-therapy-a-retrospective-cohort-study-of-103-patients
#2
Jacomien Aleman, Dirk Jan F Moojen, Marc L van Ogtrop, Rudolf W Poolman, Eric J F Franssen
Objectives : Antimicrobial therapy is one of the cornerstones of orthopaedic implant-related infections (OIRI) treatment. Infections with Gram-positive bacteria are often treated with vancomycin, penicillin or clindamycin. A recent IDSA guideline suggests increasing the dose of vancomycin to increase the trough vancomycin target serum concentrations. This is deemed necessary because of an observed decrease in vancomycin susceptibility among Gram-positive bacteria. However, elevated vancomycin concentrations are correlated with the risk of nephrotoxicity, especially with prolonged therapy...
2018: Journal of Bone and Joint Infection
https://www.readbyqxmd.com/read/29746714/evaluation-of-the-effectiveness-of-dose-individualization-to-achieve-therapeutic-vancomycin-concentrations
#3
Ahmed A Abulfathi, Maxwell Chirehwa, Bernd Rosenkranz, Eric H Decloedt
The glycopeptide antibiotic vancomycin is used for treatment of methicillin-resistant Gram-positive cocci. Adequate vancomycin plasma concentrations are related to bacterial cure. However, inter- and intrapatient variability make it difficult to achieve therapeutic vancomycin concentrations. The primary objective of this study was to determine the effectiveness of using computerized therapeutic drug monitoring (TDM) to assist in achieving therapeutic vancomycin concentrations at a tertiary hospital in South Africa...
May 10, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29746432/effect-of-extracorporeal-membrane-oxygenation-on-the-new-vancomycin-dosing-regimen-in-critically-ill-patients-receiving-continuous-venovenous-hemofiltration
#4
Chi-Ju Yang, Chia-Wei Wu, Chien-Chih Wu
BACKGROUND: The optimal dosing regimen of vancomycin for critically ill patients receiving continuous venovenous hemofiltration (CVVH) remains controversial, not to mention those with concurrent use of extracorporeal membrane oxygenation (ECMO). We aimed to determine if a new dosing regimen can achieve the target vancomycin trough concentration (Ctrough) of 10-20 mcg/mL in patients receiving CVVH with or without ECMO. METHODS: We conducted a retrospective study by enrolling patients who received vancomycin while undergoing CVVH...
June 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29744794/evaluation-of-risk-factors-for-vancomycin-induced-nephrotoxicity
#5
So Jin Park, Na Ri Lim, Hyo Jung Park, Jae Wook Yang, Min-Ji Kim, Kyunga Kim, Yong Won In, Young Mee Lee
Background Vancomycin is a glycopeptide antibiotic of choice for the treatment of serious infections caused by multi-resistant Gram-positive bacteria. However, vancomycin-associated nephrotoxicity (VAN) often limits its use. Previous data suggested a few risk factors of VAN, including higher mean vancomycin trough level, higher daily doses, old age, long duration of vancomycin therapy, and concomitant nephrotoxins. Objective To evaluate the incidence and risk factors of VAN and determine whether higher vancomycin trough concentrations were associated with a greater risk for VAN...
May 9, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29742643/pharmacokinetic-monitoring-of-vancomycin-in-cystic-fibrosis-is-it-time-to-move-past-trough-concentrations
#6
Nicholas M Fusco, William A Prescott, Calvin J Meaney
BACKGROUND: A correlation between vancomycin trough concentrations (VTC) and area under the curve (AUC) to minimum inhibitory concentration (MIC) ratio (AUC/MIC) has not been established in children/adolescents with cystic fibrosis (CF). The primary objective of this study was to determine the correlation between measured VTCs and AUC/MIC using population-based pharmacokinetics. METHODS: A retrospective cohort study of children/adolescents diagnosed with CF, age 6 to < 18 years, treated with vancomycin (VAN) for methicillin-resistant Staphylococcus aureus (MRSA) infection was conducted...
May 4, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29739110/comparison-of-new-liquid-chromatography-mass-spectrometry-method-and-enzyme-multiplied-immunoassay-technique-for-routine-therapeutic-drug-monitoring-of
#7
Guiyan Yuan, Huanjun Liu, Abdul S Shaikh, Rui Zhang, Pingli Li, Benjie Wang, Ruichen Guo
BACKGROUND: Therapeutic drug monitoring of vancomycin is very valuable due to the good correlation between trough levels and clinical outcome. Therefore, it is important to accurately determine the concentration of vancomycin in patient plasma for adequate dose-adjustment. The objective of this study was to develop a new liquid chromatography-mass spectrometry (LC-MS) method for determination of vancomycin in patient plasma and compare the results with those obtained from enzyme-multiplied immunoassay technique (EMIT)...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29720909/use-of-individual-pharmacokinetics-to-improve-time-to-therapeutic-vancomycin-trough-in-pediatric-oncology-patients
#8
Calvin L Miller, S Alexander Winans, John J Veillette, Steven C Forland
OBJECTIVE: Optimization of vancomycin dosing is difficult in children, given rapid drug clearance and patient heterogeneity. We sought to evaluate the impact of dosing using individual pharmacokinetic parameters on time to goal trough concentration in pediatric oncology patients. METHODS: A retrospective review was conducted to assess vancomycin dosing in the pediatric oncology unit at Loma Linda University Children's Hospital between January 2013 and August 2013 (standard dosing group [SDG])...
March 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29698961/impact-of-serum-vancomycin-trough-levels-in-the-treatment-of-central-nervous-system-shunt-infections-caused-by-coagulase-negative-staphylococci
#9
Ashley Gibson, Sheldon L Kaplan, Jesus G Vallejo
Coagulase-negative staphylococci (CoNS) are a common cause of pediatric ventricular shunt infections. The Infectious Diseases Society of America recommends vancomycin serum troughs of 15-20 µg/mL when treating CoNS shunt infections in adult patients. We report a series of pediatric cases of CoNS shunt infections in which clinical cure was obtained with troughs < 15 µg/mL. These findings question the relevance of this recommendation in pediatric patients.
April 26, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29642744/evaluation-of-continuous-infusion-vancomycin-administration-in-a-critically-ill-trauma-population
#10
Brittany D Bissell, Gina Riggi, Christopher Morrison
Vancomycin is a first-line antibiotic for empiric treatment of gram-positive infections in the trauma intensive care unit. When dosed intermittently, difficulties arise from trough collection and drug monitoring. The objective of this study was to evaluate time to goal vancomycin levels comparing a continuous infusion protocol when compared to standard intermittent infusion dosing. This was a retrospective cohort of patients admitted to the trauma intensive care unit between July 2011 and July 2015 receiving vancomycin for at least 48 hours...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29606259/-vancomycin-nephrotoxicity-frequency-and-mechanistic-aspects
#11
Yosu Luque, Laurent Mesnard
Vancomycin, discovered in 1953 and widely used today, has a nephrotoxic potential that has long been debated. The frequency of renal involvement is variable and can range from 5% to 30% depending concomitant risk factors: overdose, chronic kidney disease, obesity, hypovolemia, and use of other nephrotoxic drugs as aminoglycosides. Its association with piperacillin-tazobactam also appears to increase the risk of nephrotoxicity. This hypothesis should be confirmed experimentally. Vancomycin-induced oxidative stress in tubular cells and intraluminal cast formation are the two physiopathological mechanisms explaining its nephrotoxicity...
April 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29602981/population-pharmacokinetics-of-vancomycin-and-auc-guided-dosing-in-chinese-neonates-and-young-infants
#12
Yewei Chen, Dan Wu, Min Dong, Yiqing Zhu, Jinmiao Lu, Xiaoxia Li, Chao Chen, Zhiping Li
OBJECTIVES: To develop a population pharmacokinetic (PK) model for vancomycin in Chinese neonates and infants less than 2 months of age (young infants) with a wide gestational age range, in order to determine the appropriate dosing regimen for this population. METHODS: We performed a retrospective chart review of patients from the neonatal intensive care unit (NICU) at Children's Hospital of Fudan University to identify neonates and young infants treated with vancomycin from May 2014 to May 2017...
March 30, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29590376/incidence-of-nephrotoxicity-among-pediatric-patients-receiving-vancomycin-with-either-piperacillin-tazobactam-or-cefepime-a-cohort-study
#13
Kathryn M Cook, Jessica Gillon, Alison G Grisso, Ritu Banerjee, Natalia Jimenez-Truque, Elizabeth J Phillips, Sara L Van Driest
Background: Recent studies in adults have found an incidence of acute kidney injury (AKI) in patients treated with a combination of vancomycin and piperacillin-tazobactam (TZP) that is greater than that expected with either medication alone. The purpose of this study was to determine whether combination therapy with vancomycin and TZP is associated with an incidence of AKI in pediatric patients higher than that in those on combination therapy with vancomycin and cefepime. Methods: We performed a retrospective single-center matched-cohort study of pediatric patients who received vancomycin in combination with TZP or cefepime between January 2015 and June 2016...
March 26, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29587650/biopsy-proven-vancomycin-induced-acute-kidney-injury-a-case-report-and-literature-review
#14
Anri Sawada, Kunio Kawanishi, Shohei Morikawa, Toshihiro Nakano, Mio Kodama, Mitihiro Mitobe, Sekiko Taneda, Junki Koike, Mamiko Ohara, Yoji Nagashima, Kosaku Nitta, Takahiro Mochizuki
BACKGROUND: Vancomycin is the first-line antibiotic for methicillin-resistant Staphylococcus aureus and coagulase-negative strains. The risk of vancomycin-induced acute kidney injury increases with plasma vancomycin levels. Vancomycin-induced acute kidney injury is histologically characterized by acute interstitial nephritis and/or acute tubular necrosis. However, only 12 biopsy-proven cases of vancomycin-induced acute kidney injury have been reported so far, as renal biopsy is rarely performed for such cases...
March 27, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29554847/the-impact-of-auc-based-monitoring-on-pharmacist-directed-vancomycin-dose-adjustments-in-complicated-methicillin-resistant-staphylococcus-aureus-infection
#15
Andrew M Stoessel, Cory M Hale, Robert W Seabury, Christopher D Miller, Jeffrey M Steele
OBJECTIVE: This study aimed to assess the impact of area under the curve (AUC)-based vancomycin monitoring on pharmacist-initiated dose adjustments after transitioning from a trough-only to an AUC-based monitoring method at our institution. METHODS: A retrospective cohort study of patients treated with vancomycin for complicated methicillin-resistant Staphylococcus aureus (MRSA) infection between November 2013 and December 2016 was conducted. The frequency of pharmacist-initiated dose adjustments was assessed for patients monitored via trough-only and AUC-based approaches for trough ranges: 10 to 14...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29505620/the-ratio-of-pre-dialysis-vancomycin-trough-serum-concentration-to-minimum-inhibitory-concentration-is-associated-with-treatment-outcomes-in-methicillin-resistant-staphylococcus-aureus-bacteremia
#16
Chien-Fang Fu, Jiun-Da Huang, Jann-Tay Wang, Shu-Wen Lin, Chien-Chih Wu
BACKGROUND: Vancomycin is a standard treatment for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, and its efficacy is closely linked to the recommended serum trough concentration of 15-20 mg/L. However, it is unknown how the pre-dialysis trough serum concentration (Cpre-HD) correlates with MRSA eradication in renal failure patients undergoing intermittent hemodialysis (HD). OBJECTIVE: To evaluate the relationship between Cpre-HD and the treatment outcomes in this population...
2018: PloS One
https://www.readbyqxmd.com/read/29503228/early-linezolid-associated-lactic-acidosis-in-a-patient-with-child-s-class-c-liver-cirrhosis-and-end-stage-renal-disease
#17
Chih-Ning Cheng, Shu-Wen Lin, Chien-Chih Wu
Linezolid, an oxazolidinone antibiotic, does not required dose adjustment in patients with Child's class A and B liver cirrhosis. The dose adjustment data for Child's class C liver cirrhosis is inadequate. We reported a case of Child's class C liver cirrhosis, in which lactic acidosis, an adverse effect related to prolonged use, occurred only after two weeks of linezolid treatment. A 63-year old male had underlying diseases, such as end-stage renal disease (ESRD) and Child's class C liver cirrhosis, and was admitted for hepatic encephalopathy management and liver transplantation evaluation...
March 1, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29495915/enhanced-vancomycin-elimination-in-an-infant-following-an-unsuccessful-gastroschisis-repair-surgery
#18
Leesa Prunty, David Miskell
OBJECTIVE: To report the case of an infant who required high-dose vancomycin therapy after an unsuccessful gastroschisis repair surgery. CASE SUMMARY: An infant born at 35 weeks and 5 days of gestation underwent a gastroschisis repair on day of life 47. The repair was unsuccessful causing fluid backup and accumulation into the stomach. A replogle was placed to allow for suctioning of this fluid. During this admission, the patient received 3 courses of vancomycin...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29494420/vancomycin-area-under-the-curve-simplified
#19
Paul Lewis
BACKGROUND: Serum trough concentrations as the sole means of monitoring safety and efficacy of vancomycin are insufficient. The daily area under the curve (AUC24) of serum concentration versus time to minimum inhibitory concentration (MIC) ratio of greater than 400 mg × h/L has emerged as a more robust dosing target. A simple and practical method to extrapolate AUC24 from troughs is needed. METHODS: This mathematical model computes the median and range AUC24 using the dose in mg/kg and the observed serum trough concentration...
June 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29483071/evaluating-the-effect-of-a-web-based-e-learning-tool-for-health-professional-education-on-clinical-vancomycin-use-comparative-study
#20
Stuart Evan Bond, Shelley P Crowther, Suman Adhikari, Adriana J Chubaty, Ping Yu, Jay P Borchard, Craig Steven Boutlis, Wilfred Winston Yeo, Spiros Miyakis
BACKGROUND: Internet-based learning for health professional education is increasing. It offers advantages over traditional learning approaches, as it enables learning to be completed at a time convenient to the user and improves access where facilities are geographically disparate. We developed and implemented the Vancomycin Interactive (VI) e-learning tool to improve knowledge on the clinical use of the antibiotic vancomycin, which is commonly used for treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA)...
February 26, 2018: JMIR Medical Education
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