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neonatal conjunctivitis

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https://www.readbyqxmd.com/read/28209981/fibulin-6-regulates-pro-fibrotic-tgf-%C3%AE-responses-in-neonatal-mouse-ventricular-cardiac-fibroblasts
#1
Arpita Chowdhury, Lisa Hasselbach, Frank Echtermeyer, Nidhi Jyotsana, Gregor Theilmeier, Christine Herzog
Fibulin-6, an essential component of extracellular matrix determines the architecture of cellular junctions in tissues undergoing strain. Increased expression and deposition of fibulin-6 facilitates fibroblast migration in response to TGF-β, following myocardial infarction in mouse heart. The underlying mechanism still remains elusive. In conjunction with our previous study, we have now demonstrated that in fibulin-6 knockdown (KD) fibroblasts, not only TGF-β dependent migration, but also stress fiber formation, cellular networking and subsequently fibroblast wound contraction is almost abrogated...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196405/psychosocial-interventions-for-supporting-women-to-stop-smoking-in-pregnancy
#2
REVIEW
Catherine Chamberlain, Alison O'Mara-Eves, Jessie Porter, Tim Coleman, Susan M Perlen, James Thomas, Joanne E McKenzie
BACKGROUND: Tobacco smoking remains one of the few preventable factors associated with complications in pregnancy, and has serious long-term implications for women and babies. Smoking in pregnancy is decreasing in high-income countries, but is strongly associated with poverty and is increasing in low- to middle-income countries. OBJECTIVES: To assess the effects of smoking cessation interventions during pregnancy on smoking behaviour and perinatal health outcomes...
February 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28157836/continuous-capnography-monitoring-during-resuscitation-in-a-transitional-large-mammalian-model-of-asphyxial-cardiac-arrest
#3
Praveen Chandrasekharan, Payam Vali, Munmun Rawat, Bobby Mathew, Sylvia F Gugino, Carmon Koenigschnekt, Justin Helman, Jayasree Nair, Sara Berkelhamer, Satyan Lakshminrusimha
BACKGROUND: In neonates requiring chest compression (CC) during resuscitation, neonatal resuscitation program (NRP) recommends against relying on a single feedback device such as end-tidal carbon dioxide (ETCO2) or SpO2 to determine return of spontaneous circulation (ROSC) until more evidence becomes available. METHODS: We evaluated the role of monitoring ETCO2 during resuscitation in a lamb model of cardiac arrest induced by umbilical cord occlusion (n=21). Lambs were resuscitated as per NRP guidelines...
February 3, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28149263/advantages-and-challenges-of-dried-blood-spot-analysis-by-mass-spectrometry-across-the-total-testing-process
#4
Rosita Zakaria, Katrina J Allen, Jennifer J Koplin, Peter Roche, Ronda F Greaves
INTRODUCTION: Through the introduction of advanced analytical techniques and improved throughput, the scope of dried blood spot testing utilising mass spectrometric methods, has broadly expanded. Clinicians and researchers have become very enthusiastic about the potential applications of dried blood spot based mass spectrometric applications. Analysts on the other hand face challenges of sensitivity, reproducibility and overall accuracy of dried blood spot quantification. In this review, we aim to bring together these two facets to discuss the advantages and current challenges of non-newborn screening applications of dried blood spot quantification by mass spectrometry...
December 2016: EJIFCC
https://www.readbyqxmd.com/read/28140639/measured-and-calculated-variables-of-global-oxygenation-in-healthy-neonatal-foals
#5
David M Wong, Kate L Hepworth-Warren, Beatrice T Sponseller, Joan M Howard, Chong Wang
OBJECTIVE To assess multiple central venous and arterial blood variables that alone or in conjunction with one another reflect global oxygenation status in healthy neonatal foals. ANIMALS 11 healthy neonatal foals. PROCEDURES Central venous and arterial blood samples were collected from healthy neonatal foals at 12, 24, 36, 48, 72, and 96 hours after birth. Variables measured from central venous and arterial blood samples included oxygen saturation of hemoglobin, partial pressure of oxygen, lactate concentration, partial pressure of carbon dioxide, and pH...
February 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28131114/optimal-pain-management-after-cesarean-delivery
#6
REVIEW
Caitlin Dooley Sutton, Brendan Carvalho
Cesarean delivery rates are increasing worldwide, and effective postoperative pain management is a key priority of women undergoing cesarean delivery. Inadequate pain management in the acute postoperative period is associated with persistent pain, greater opioid use, delayed functional recovery, and increased postpartum depression. In addition to pain relief, optimal management of patients after cesarean delivery should address the goals of unrestricted maternal mobility, minimal maternal and neonatal side effects, rapid recovery to baseline functionality, and early discharge home...
March 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/28099450/advanced-neonatal-medicine-in-china-a-national-baseline-database
#7
Xiang-Peng Liao, Selma Chipenda-Dansokho, Antoine Lewin, Nadia Abdelouahab, Shu-Qin Wei
Previous surveys of neonatal medicine in China have not collected comprehensive information on workforce, investment, health care practice, and disease expenditure. The goal of the present study was to develop a national database of neonatal care units and compare present outcomes data in conjunction with health care practices and costs. We summarized the above components by extracting data from the databases of the national key clinical subspecialty proposals issued by national health authority in China, as well as publicly accessible databases...
2017: PloS One
https://www.readbyqxmd.com/read/28092280/challenges-and-opportunities-to-enhance-global-drug-development-in-neonates
#8
Alexandra M Smith, Jonathan M Davis
PURPOSE OF REVIEW: This study reviews the history of neonatal drug development, recent legislative efforts designed to facilitate the study of therapeutic agents in neonates, and future steps necessary to advance drug development. RECENT FINDINGS: Although many federal regulations have been introduced over the past 15 years to encourage pediatric and neonatal drug development, the majority of medications that are used in the Neonatal Intensive Care Unit are not approved by the Food and Drug Administration (FDA) for use in neonates...
January 13, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28078599/besifloxacin-ophthalmic-suspension-0-6-compared-with-gatifloxacin-ophthalmic-solution-0-3-for-the-treatment-of-bacterial-conjunctivitis-in-neonates
#9
Christine M Sanfilippo, Catherine M Allaire, Heleen H DeCory
PURPOSE: The aim of this study was to evaluate the safety and efficacy of topical besifloxacin ophthalmic suspension 0.6% compared with gatifloxacin ophthalmic solution 0.3% in the treatment of bacterial conjunctivitis in neonates. METHODS: This was a multicenter, randomized, double-masked, parallel group study. Subjects ≤31 days of age with severity grade ≥1 (scale 0-3) for both conjunctival discharge and conjunctival hyperemia were randomized to besifloxacin or gatifloxacin instilled three times daily for 7 days, and completed five study visits (three clinic visits and two phone calls)...
January 11, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28002109/neonatal-bacterial-conjunctivitis-in-korea-in-the-21st-century
#10
Kang Yeun Pak, Sung Il Kim, Jong Soo Lee
PURPOSE: To investigate the microbial cause and antibiotic susceptibility of neonatal bacterial conjunctivitis in Korean patients in the 21st century. METHODS: We retrospectively reviewed the medical records of patients diagnosed with neonatal bacterial conjunctivitis between January 2000 and December 2015. We recorded the organism, antibiotic susceptibility, and antibiotics used. RESULTS: A total of 82 neonates were included in the study (53 males and 29 females), with a mean age of 17...
December 20, 2016: Cornea
https://www.readbyqxmd.com/read/27937684/yinzhihuang-oral-liquid-in-the-treatment-of-neonatal-jaundice-a-meta-analysis
#11
Jie Zeng, Su-Jun Wang, Yong-Mei Li, Hang-Shan Li, Qian Luo, Yun-Ying Huang, Qun Jiang, Li Wang
CONTEXT: Yinzhihuang oral liquid, a well-known Chinese herbal formula, is a clinical drug for the treatment of neonatal jaundice, and a number of clinical trials have been published addressing this issue, but there is no comprehensive analysis that evaluates its efficacy for the treatment of newborn with hyperbilirubinaemia. OBJECTIVE: A meta-analysis was conducted to evaluate the efficacy of Yinzhihuang oral liquid on neonatal jaundice. METHODS: Search was performed throughout PubMed, Cochrane Library, EMBASE, Ovid, Wanfang, VIP Medicine Information System (VMIS) and China National Knowledge Infrastructure (CNKI) databases up to December 2015...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27846760/outcome-of-breastfed-infants-following-post-partum-methylergonovine-treatment
#12
Oded Gilad, Paul Merlob, Bracha Stahl, Noa Averbuch, Gil Klinger
OBJECTIVE: To evaluate maternal and breastfed infant's outcome following post-partum maternal use of methylergonovine. METHODS: A prospective, controlled observational study design was used. Mothers who contacted Beilinson Teratology Information Service (BELTIS) were followed by phone interview. Data on lactation, neonatal symptoms and outcomes at the age of 1-3 years were obtained. Mothers' breastfeeding while treated with methylergonovine and their infants were compared to a matched control group of breastfeeding mothers using a drug known to be safe during lactation (amoxicillin)...
November 16, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27845968/epidemiology-of-zika
#13
Carmen C Deseda
PURPOSE OF REVIEW: Zika virus (ZIKV) is the latest 'emerging virus' that has affected the Americas. First identified in the mid-20th century in Uganda, it was described as a vector arthropod-borne virus (arbovirus) and subsequently found capable of producing illness in humans. The illness was not different from other flavivirus infections and caused a relatively mild disease characterized by low-grade fever, nonspecific exanthem, nonpurulent conjunctivitis, and mild to moderate arthralgia...
February 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/27831550/impact-of-a-dedicated-neonatal-stabilization-room-and-process-changes-on-stabilization-time
#14
S Shivananda, S Gupta, S Thomas, L Babb, C-L Meyer, A Symington, B Paes, G K Suresh
OBJECTIVE: Our objective was to evaluate the impact of a dedicated resuscitation and stabilization (RAS) room and process changes on infant stabilization time. STUDY DESIGN: A prospective quality improvement study was conducted on preterm infants in a tertiary care center. A dedicated RAS room, preresuscitation huddle, infant-isolette-ventilator pairing and improved documentation were implemented. The primary outcome was median time to stabilization and secondary outcomes were illness severity on day 1 and morbidity at discharge...
November 10, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27795225/the-clinical-significance-of-schistocytes-a-prospective-evaluation-of-the-icsh-schistocyte-guidelines
#15
Elise Schapkaitz, Michael Halefom Mezgebe
OBJECTIVE: The presence of ≥ 1% schistocytes on peripheral blood smear (PBS) is an important criterion for the diagnosis of a thrombotic microangiopathy (TMA). The reporting of schistocytes has been standardized by the International Council for Standardization in Hematology (ICSH).Despite the availability of guidelines, the assessment of schistocytes remains subjective. More recently, the automated fragmented red cell (FRC) parameter has been evaluated. However, local studies are not available...
October 31, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27766599/fatty-acid-microemulsion-for-the-treatment-of-neonatal-conjunctivitis-quantification-characterisation-and-evaluation-of-antimicrobial-activity
#16
Ummara Butt, Amr ElShaer, Lori A S Snyder, Athina Chaidemenou, Raid G Alany
Fatty acids (FAs) are used by many organisms as defence mechanism against virulent bacteria. The high safety profile and broad spectrum of activity make them potential alternatives to currently used topical antibiotics for the treatment of eye infections in neonates. The current study utilised a Design of Experiment approach to optimise the quantification of five fatty acids namely; lauric acid, tridecanoic acid, myristoleic acid, palmitoleic acid and α-linolenic acid. The significance of the influence of the experimental parameters such as volume of catalyst, volume of n-hexane, incubation temperature, incubation time and the number of extraction steps on derivatisation was established by statistical screening with a factorial approach...
December 2016: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/27711045/non-invasive-inhaled-nitric-oxide-in-the-treatment-of-hypoxemic-respiratory-failure-in-term-and-preterm-infants
#17
R Sahni, X Ameer, K Ohira-Kist, J-T Wung
OBJECTIVES: Inhaled nitric oxide (iNO) is effective in conjunction with tracheal intubation (TI) and mechanical ventilation (MV) for treating arterial pulmonary hypertension and hypoxemic respiratory failure (HRF) in near-term and term newborns. Non-invasive respiratory support with nasal continuous positive airway pressure (CPAP) is increasingly used to avoid morbidity associated with TI and MV, yet the effectiveness of iNO delivery via nasal CPAP remains unknown. To evaluate the effectiveness of iNO delivered via the bubble nasal CPAP system in term and preterm newborns with HRF...
January 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27684833/use-of-the-glidescope-video-laryngoscope-for-intubation-during-ex-utero-intrapartum-treatment-in-a-fetus-with-a-giant-cyst-of-the-4th-branchial-cleft-a-case-report
#18
Sung Hye Byun, So Young Lee, Seong Yeon Hong, Taeha Ryu, Baek Jin Kim, Jin Yong Jung
INTRODUCTION: In fetuses who are predicted to be at risk of catastrophic airway obstruction at delivery, the ex utero intrapartum treatment (EXIT) procedure is useful for securing the fetal airway while maintaining fetal oxygenation via placental circulation. Factors, including poor posture of the fetus and physician, narrow visual field, and issues of contamination in the aseptic surgical field, make fetal intubation during the EXIT procedure difficult. Herein, we report our experience of the usefulness of the GlideScope video laryngoscope (GVL) for intubation during the EXIT procedure...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27642383/-neonatal-conjunctivitis-in-the-district-of-glidji-in-southern-togo-a-cross-sectional-study-about-159-new-borns
#19
Vonor Kokou, Maneh Nidain, Nononsaa Batomguela Kassoula, Fiaty-Amenouvor Kwassi, Banla Meba, Balo Komi Patrice
INTRODUCTION: Describe the epidemiology of neonatal conjunctivitis in the Canton of Glidji in southern Togo. METHODS: We conducted a cross-sectional study in 4 Satellite Health Care Units in the Canton of Glidji from 19 March to 13 May 2009 (8 weeks). All newborns were included in the study and neonatal conjunctivitis was defined by the presence in a newborn of at least two of the following signs: conjunctival hyperemia, eyelid swelling, chemosis, purulent discharges, lacrimation...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27633108/probiotics-prebiotics-and-synbiotics-for-the-prevention-of-necrotizing-enterocolitis
#20
REVIEW
Kathene C Johnson-Henry, Thomas R Abrahamsson, Richard You Wu, Philip M Sherman
Necrotizing enterocolitis (NEC) is a devastating intestinal disease in preterm infants characterized by barrier disruption, intestinal microbial dysbiosis, and persistent inflammation of the colon, which results in high mortality rates. Current strategies used to manage this disease are not sufficient, although the use of human breast milk reduces the risk of NEC. Mother's milk is regarded as a fundamental nutritional source for neonates, but pasteurization of donor breast milk affects the composition of bioactive compounds...
September 2016: Advances in Nutrition
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