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https://www.readbyqxmd.com/read/29692686/noacs-replace-vka-as-preferred-oral-anticoagulant-among-new-patients-a-drug-utilization-study-in-560-pharmacies-in-the-netherlands
#1
J M van den Heuvel, A M Hövels, H R Büller, A K Mantel-Teeuwisse, A de Boer, A H Maitland-van der Zee
Background: In 2012, around 400.000 patients in the Netherlands were treated with Vitamin K Antagonists (VKA) for thromboembolic diseases. Since 2011, non-VKA oral anticoagulants (NOACs) are available. NOACs do not require frequent INR monitoring which benefits patients, but also imposes a risk of reduced therapy adherence. The objective of this study is to describe uptake and patient adherence of NOACs in The Netherlands until October 2016. Methods: Prescription data for 247...
2018: Thrombosis Journal
https://www.readbyqxmd.com/read/29672845/drug-induced-proarrhythmia-and-torsade-de-pointes-a-primer-for-students-and-practitioners-of-medicine-and-pharmacy
#2
REVIEW
J Rick Turner, Ignacio Rodriguez, Emily Mantovani, Gary Gintant, Peter R Kowey, Ralph J Klotzbaugh, Krishna Prasad, Philip T Sager, Norman Stockbridge, Colette Strnadova
Multiple marketing withdrawals due to proarrhythmic concerns occurred in the United States, Canada, and the United Kingdom in the late 1980s to early 2000s. This primer reviews the clinical implications of a drug's identified proarrhythmic liability, the issues associated with these safety-related withdrawals, and the actions taken by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) and by regulatory agencies in terms of changing drug development practices and introducing new nonclinical and clinical tests to asses proarrhythmic liability...
April 19, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29667759/incidence-predictors-and-clinical-management-of-hyperkalaemia-in-new-users-of-mineralocorticoid-receptor-antagonists
#3
Marco Trevisan, Pietro de Deco, Hairong Xu, Marie Evans, Bengt Lindholm, Rino Bellocco, Peter Barany, Tomas Jernberg, Lars H Lund, Juan J Carrero
BACKGROUND: Concerns for hyperkalaemia limit the use of mineralocorticoid receptor antagonists (MRAs). The frequency of MRA-associated hyperkalaemia in real-world settings and the extent of subsequent MRA discontinuation are poorly quantified. METHODS AND RESULTS: Observational study including all Stockholm citizens initiating MRA therapy during 2007-2010. Hyperkalaemias were identified from all potassium (K+ ) measurements in healthcare. MRA treatment lengths and dosages were obtained from complete collection of pharmacy dispensations...
April 18, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29621715/comparison-of-phosphodiesterase-type-v-inhibitors-use-in-eight-european-cities-through-analysis-of-urban-wastewater
#4
Ana Causanilles, Daniela Rojas Cantillano, Erik Emke, Richard Bade, Jose Antonio Baz-Lomba, Sara Castiglioni, Erika Castrignanò, Emma Gracia-Lor, Félix Hernández, Barbara Kasprzyk-Hordern, Juliet Kinyua, Ann-Kathrin McCall, Alexander L N van Nuijs, Benedek G Plósz, Pedram Ramin, Nikolaos I Rousis, Yeonsuk Ryu, Kevin V Thomas, Pim de Voogt
In this work a step forward in investigating the use of prescription drugs, namely erectile dysfunction products, at European level was taken by applying the wastewater-based epidemiology approach. 24-h composite samples of untreated wastewater were collected at the entrance of eight wastewater treatment plants serving the catchment within the cities of Bristol, Brussels, Castellón, Copenhagen, Milan, Oslo, Utrecht and Zurich. A validated analytical procedure with direct injection of filtered aliquots by liquid chromatography-tandem mass spectrometry was applied...
April 2, 2018: Environment International
https://www.readbyqxmd.com/read/29600808/anticholinergics-influence-transition-from-normal-cognition-to-mild-cognitive-impairment-in-older-adults-in-primary-care
#5
Noll L Campbell, Kathleen A Lane, Sujuan Gao, Malaz A Boustani, Fred Unverzagt
STUDY OBJECTIVE: To determine the influence of anticholinergic medications on transitions in cognitive diagnosis of older adults in primary care. DESIGN: This observational cohort study was conducted over a mean follow-up of 3.2 years. Anticholinergic exposure was defined by pharmacy dispensing and claims records. Cognitive diagnosis was performed by an expert panel at baseline and annually up to four years. DATA SOURCE: Medication exposure and other clinical data were extracted from the Indiana Network for Patient Care (INPC), while the cognitive diagnosis was derived from a cognitive screening and diagnosis study...
March 30, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29573273/patterns-of-topical-corticosteroids-prescriptions-in-children-with-asthma
#6
Ali Arabkhazaeli, Susanne J H Vijverberg, Maaike van der Lee, Cornelis K van der Ent, Carla A Bruijnzeel-Koomen, Marjolein S de Bruin-Weller, Jan A Raaijmakers, Anke H Maitland-van der Zee
OBJECTIVES: To study topical corticosteroid use in Dutch asthmatic children using pharmacy dispensing data and to assess whether Dutch physicians prescribe topical corticosteroids in this population according to clinical guidelines. METHODS: Medication histories of children using asthma medication were extracted from the pharmacy dispensing system in 100 Dutch community pharmacies. The incidence rate and the potency of topical corticosteroid prescriptions per age were assessed...
March 24, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29560269/utilization-of-gabapentin-by-people-in-treatment-for-substance-use-disorders-in-belgium-2011-2014-a-cross-sectional-study
#7
Luk Van Baelen, Karin De Ridder, Jérôme Antoine, Lies Gremeaux
Background: Although gabapentin has been licensed in the European Union only for neuropathic pain and epilepsy for patients who have partial seizures, it has also been prescribed in treatment for substance use disorders. Many studies report the potential risk of abuse of gabapentin by people with substance use disorders. The objective of this paper is to determine if people who have been in treatment for substance use disorders bought gabapentin in a time span that could indicate consumption at a dose that exceeded the maximum approved dose of 3600 mg/day...
2018: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29531414/ward-based-clinical-pharmacists-and-hospital-readmission-a-non-randomized-controlled-trial-in-sri-lanka
#8
Lelwala Guruge Thushani Shanika, Shaluka Jayamanne, Chandrani Nirmala Wijekoon, Judith Coombes, Dhineli Perera, Fahim Mohamed, Ian Coombes, Hithanadura Asita De Silva, Andrew Hamilton Dawson
Objective: To assess if a ward-based clinical pharmacy service resolving drug-related problems improved medication appropriateness at discharge and prevented drug-related hospital readmissions. Method: Between March and September 2013, we recruited patients with noncommunicable diseases in a Sri Lankan tertiary-care hospital, for a non-randomized controlled clinical trial. The intervention group received usual care and clinical pharmacy service. The intervention pharmacist made prospective medication reviews, identified drug-related problems and discussed recommendations with the health-care team and patients...
March 1, 2018: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/29501781/economic-and-practical-considerations-in-the-treatment-of-oral-mucosal-chronic-graft-versus-host-disease
#9
Sharon Elad, Kevin Zinchuk, Shuli Li, Corey Cutler, Jane Liesveld, Nathaniel S Treister
Chronic graft-versus-host disease (cGVHD) frequently affects the oral mucosa and is generally responsive to topical immunomodulatory therapies. Clinicians may benefit from guidance in choosing the most appropriate therapy with respect to practicality and cost. To assess the economic considerations related to topical immunomodulatory treatments for management of oral mucosal cGVHD and their practical implications. Topical treatments used for management of oral cGVHD were obtained from the National Institutes of Health Consensus document for ancillary and supportive care...
March 2, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29319215/considerations-of-prescribers-and-pharmacists-for-the-use-of-non-selective-%C3%AE-blockers-in-asthma-and-copd-patients-an-explorative-study
#10
Esther Kuipers, Michel Wensing, Peter A G M De Smet, Martina Teichert
RATIONALE, AIMS, AND OBJECTIVES: Despite recommendations in prevailing guidelines to avoid the use of non-selective (NS) β-blockers in patients with asthma or COPD, on average, 10 patients per community pharmacy receive NS β-blockers monthly. The aim of our study was to identify the reasons of prescribers and pharmacists to treat asthma and COPD patients with NS β-blockers. METHODS: Fifty-three community pharmacists in the Netherlands selected patients with actual concurrent use of inhalation medication and NS β-blockers...
April 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29247115/mystery-shopping-and-coaching-as-a-form-of-audit-and-feedback-to-improve-community-pharmacy-management-of-non-prescription-medicine-requests-an-intervention-study
#11
Jack Charles Collins, Carl Richard Schneider, Clare Louise Naughtin, Frances Wilson, Abilio Cesar de Almeida Neto, Rebekah Jane Moles
OBJECTIVES: To determine whether repeated mystery shopping visits with feedback improve pharmacy performance over nine visits and to determine what factors predict an appropriate outcome. DESIGN: Prospective, parallel, repeated intervention, repeated measures mystery shopping (pseudopatient) design. SETTING: Thirty-six community pharmacies in metropolitan Sydney, Australia in March-October 2015. PARTICIPANTS: Sixty-one University of Sydney pharmacy undergraduates acted as mystery shoppers...
December 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29164957/expectations-concerns-and-needs-of-patients-who-start-drugs-for-chronic-conditions-a-prospective-observational-study-among-community-pharmacies-in-serbia
#12
Katarina M Vučićević, Branislava R Miljković, Bojana C Golubović, Marija N Jovanović, Sandra D Vezmar Kovačević, Milica D Ćulafić, Milena M Kovačević, Johan J de Gier
BACKGROUND: During the initiation of treatment of a chronic disease, patients may have varying interests, expectations, concerns, and reasons to stop treatment, influencing compliance with prescribed treatment. Thus, healthcare professionals are expected to integrate these needs into medicines management. OBJECTIVES: To determine what information is important to patients; assess predictors of patients' interests, expectations, concerns, reasons to stop therapy; evaluate drug-related problems following initiation of therapy and summarize how pharmacists resolve them during patient-pharmacist counselling...
December 2018: European Journal of General Practice
https://www.readbyqxmd.com/read/29160461/indicators-related-to-the-rational-use-of-medicines-and-its-associated-factors
#13
Marina Guimarães Lima, Juliana Álvares, Augusto Afonso Guerra, Ediná Alves Costa, Ione Aquemi Guibu, Orlando Mario Soeiro, Silvana Nair Leite, Margô Gomes de Oliveira Karnikowski, Karen Sarmento Costa, Francisco de Assis Acurcio
OBJECTIVE: To evaluate indicators related to the rational use of medicines and its associated factors in Basic Health Units. METHOD: This is a cross-sectional study carried out in a representative sample of Brazilian cities included in the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015). The data were collected by interviews with users, medicine dispensing professionals, and prescribers; and described by prescription, dispensing, and health services indicators...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28683782/a-descriptive-study-of-self-medication-practices-among-sri-lankan-national-level-athletes
#14
A D A Fernando, L M H Bandara, H M S T Bandara, S Pilapitiya, A de Silva
BACKGROUND: Intake of medicines and supplements is widespread among the professional athletes in developed countries and there are reports to suggest inappropriate self-administration of medicine. Data from South Asia on this area is lacking. This study examined self-medication practices with regard to use of allopathic and herbal/traditional medicines among national -level Sri Lankan athletes. RESULTS: 209 athletes from 15 national sport teams were assessed using an anonymous, interviewer administered questionnaire...
July 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28625935/evaluation-of-prescription-along-three-health-care-periods-in-the-elderly
#15
Fannie Santoni, Valéry Antoine, Alberto di Castri, Maurice Viala, Laetitia Geronimi-Robelin, Cédric LeGuillou, Christine de Taddeo, Sophie Bastide, Claude Jeandel, Benoit de Wazieres
Polypharmacy, potentially inappropriate prescriptions and inadequate coordination between prescribers are among main factors explaining the occurrence of adverse drug events in elderly patients. Prospective and descriptive study of medication prescriptions for elderly patients during a continuous period of health-care: entry in an acute geriatric unit (T1), at discharge (T2) and two months after hospitalization (T3). A global iatrogenic risk was defined: presence of poly-pharmacy and/or PPI (Laroche criteria) and/or absence of quality indicators for prescription according to the French health authority...
June 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28589543/beta-blocker-use-and-fall-risk-in-older-individuals-original-results-from-two-studies-with-meta-analysis
#16
Annelies C Ham, Suzanne C van Dijk, Karin M A Swart, Anke W Enneman, Nikita L van der Zwaluw, Elske M Brouwer-Brolsma, Natasja M van Schoor, M Carola Zillikens, Paul Lips, Lisette C P G M de Groot, Albert Hofman, Renger F Witkamp, André G Uitterlinden, Bruno H Stricker, Nathalie van der Velde
AIMS: To investigate the association between use of β-blockers and β-blocker characteristics - selectivity, lipid solubility, intrinsic sympathetic activity (ISA) and CYP2D6 enzyme metabolism - and fall risk. METHODS: Data from two prospective studies were used, including community-dwelling individuals, n = 7662 (the Rotterdam Study) and 2407 (B-PROOF), all aged ≥55 years. Fall incidents were recorded prospectively. Time-varying β-blocker use was determined using pharmacy dispensing records...
October 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28588941/physicochemical-equivalence-of-generic-antihypertensive-medicines-equimeds-protocol-for-a-quality-of-medicines-assessment
#17
Julie Redfern, Rufus Adesoji Adedoyin, Sandra Ofori, Raghupathy Anchala, Vamadevan S Ajay, Luciano De Andrade, Jose Zelaya, Harparkash Kaur, Dina Balabanova, Mahmoud U Sani
BACKGROUND: Prevention and optimal management of hypertension in the general population is paramount to the achievement of the World Heart Federation (WHF) goal of reducing premature cardiovascular disease (CVD) mortality by 25% by the year 2025 and widespread access to good quality antihypertensive medicines is a critical component for achieving the goal. Despite research and evidence relating to other medicines such as antimalarials and antibiotics, there is very little known about the quality of generic antihypertensive medicines in low-income and middle-income countries...
August 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28430007/the-feasibility-and-impact-of-prospective-medication-review-in-the-emergency-department
#18
Billy Sin, Kwong Lau, Richard Tong, Josel Ruiz, Kimberly Sarosky, Robert DiGregorio, Shalom Butel, Sylvie de Souza
OBJECTIVE: We evaluated the feasibility and impact of prospective medication review (PMR) in the emergency department (ED). METHODS: This was a retrospective cohort study of all nonadmitted ED patients who were prescribed medication orders by ED clinicians from September 2014 to September 2015 to determine the time intervals utilized during each step of the medication use process and quantify the number of interventions conducted by the pharmacist and cost avoidance accrued from the interventions...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28368076/antimicrobial-consumption-and-antimicrobial-resistance-a-snapshot-of-an-italian-neuromuscular-rehabilitation-center
#19
Giuseppina Barberi, Maria Cristina De Cola, De Cola Dell'Utri, Sara Melardi, Bernardo Alagna, Placido Bramanti, Antonio Cascio
The paper presents a snapshot of the incidence of antimicrobial-resistant microorganisms and antimicrobial consumption in an Italian rehabilitation center over a two-year period (2014-2015). Data on microorganism identification and antimicrobial susceptibility testing were obtained from the diagnostic laboratory of the hospital. A set of indicators was assessed, including the incidence density of resistant isolates per 1000 patient-days (IDRI). Data on antimicrobial consumption, semi-annually, obtained from the hospital pharmacy, were expressed as Defined Daily Dose (DDD) per 1000 patient-days...
April 2017: New Microbiologica
https://www.readbyqxmd.com/read/28318318/non-guideline-recommended-prescribing-of-proton-pump-inhibitors-in-the-general-population
#20
Emma Mares-García, Antonio Palazón-Bru, Álvaro Martínez-Martín, David Manuel Folgado-de la Rosa, Avelino Pereira-Expósito, Vicente Francisco Gil-Guillén
OBJECTIVES: To determine the magnitude of non-guideline-recommended prescribing (NGRP) of proton pump inhibitors (PPIs) in the general population, its associated factors and expense. METHODS: We undertook a cross-sectional observational study in three community pharmacies in a Spanish region in 2013 involving a total of 302 patients with a prescription for PPIs. The main variable was the NGRP of PPIs. Secondary variables were: gender, age, antidepressants, osteoporosis, osteoarthritis, prescription cost per month and total number of chronic diseases...
October 2017: Current Medical Research and Opinion
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