Reza Chahardoli, Behrouz Robat-Jazi, Fereidoun Azizi, Atieh Amouzegar, Davood Khalili, Azita Zadeh-Vakili, Fatemeh Mansouri, Ali Akbar Saboor-Yaraghi
BACKGROUND: Hashimoto's thyroiditis (HT) is an autoimmune disease characterized by the destruction of thyroid cells through immune processes involving T helper (Th)1 cytokines. This clinical trial investigates the impact of vitamin D supplementation on serum cytokine levels and gene expression in CD4+ T cells from HT patients, aiming to understand its effects on Th-1, Th-2, Th-17, and regulatory T (Treg) cell-associated factors. METHODS: Female patients were randomly assigned in a double-blind design to either a vitamin D-supplemented group, which received cholecalciferol [1, 25(OH)2D3] at a dose of 50,000 IU, or the placebo group, which received a weekly placebo for a duration of three months...
January 25, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets