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Vitamin D AND cholesterol

L J Li, Y Z Guan, F Lü, Y W Song, X J Xu, Y Jiang, O Wang, W B Xia, X P Xing, M Li
Objective: To investigate the glucose and lipid metabolic disorders in patients with myasthenia gravis (MG) without glucocorticoid therapy, and the relationships between insulin, insulin resistance, muscle strength, serum levels of osteocalcin, 25-hydroxy vitamin D (25OHD) and glucose and lipid metabolism. Methods: A total of 102 MG patients [(40±11) years old, 43 males and 59 females] without glucocorticoid treatment were enrolled in this cross-sectional study. Height, weight and the handgrip of dominant hands were measured...
February 27, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Hanifi Ucpunar, Ismet Yalkin Camurcu, Serda Duman, Esra Ucpunar, Hakan Sofu, Avni Ilhan Bayhan
Background and purpose - Patients with slipped capital femoral epiphysis (SCFE) are phenotypically overweight or obese and may therefore require clinical follow-up of obesity-related disorders. We evaluated obesity-related disorders such as dyslipidemia, type 2 diabetes mellitus (DM), and vitamin-D deficiency during the postoperative period in patients with SCFE. Patients and methods - 51 patients who were operated and followed-up for SCFE and 62 healthy adolescents without SCFE (control group) were included in this retrospective study...
March 9, 2018: Acta Orthopaedica
Sahar M El Agaty
OBJECTIVES: To assess the effect of vitamin D2 and to elucidate the underlying mechanisms on acute myocardial injury induced by isoproterenol (ISO) in diabetic rats. METHODS: Rats were divided into control rats, diabetic rats (DM), diabetic rats received ISO (DM-ISO), and diabetic rats pretreated with vitamin D2 and received ISO (DM-D2 -ISO). RESULTS: Vitamin D2 pretreatment significantly decreased fasting glucose and myocardial malondialdehyde, associated with increased insulin, myocardial glutathione and superoxide dismutase in DM-D2 -ISO versus DM-ISO...
March 8, 2018: Archives of Physiology and Biochemistry
Krzysztof Prusik, Jakub Kortas, Katarzyna Prusik, Jan Mieszkowski, Joanna Jaworska, Wojciech Skrobot, Marcin Lipinski, Ewa Ziemann, Jedrzej Antosiewicz
Objective: Different studies have demonstrated that regular exercise can induce changes in the lipid profile, but results remain inconclusive. Available data suggest that correction of vitamin D deficiency can improve the lipid profile. In this study, we have hypothesized that Nordic Walking training will improve lipid profile in elderly women supplemented with vitamin D. Methods: A total of 109 elderly women (68 ± 5.12 years old) took part in the study. First group [experimental group (EG): 35 women] underwent 12 weeks of Nordic Walking (NW) training combined with vitamin D supplementation (4,000 IU/day), second group [supplementation group (SG): 48 women] was only supplemented with vitamin D (4,000 IU/day), and third group [control group (CG): 31 women] was not subject to any interventions...
2018: Frontiers in Endocrinology
Gulab Chandra, Anjali Aggarwal, Muneendra Kumar, Anil Kumar Singh
Thirty-two advanced pregnant multiparous Sahiwal cows were used to study the effect of additional zinc (Zn) and vitamin E (VE) supplementation on hormonal and biochemical changes. Cows were randomly assigned to four groups and fed a basal diet of compounded concentrate, berseem fodder, and wheat straw in a ratio of 60:20:20. The groups were: (1) the basal diet with no supplement (control treatment); (2) the basal diet supplemented with 60 mg/kg DM/cow daily of Zn (Zn treatment); (3) the basal diet supplemented with 1000 IU/cow daily of vitamin E (VE treatment); and (4) the basal diet supplemented with a combination of 60 mg Zn/kg DM/cow and 1000 IU vitamin E/cow/d (Zn + VE treatment)...
February 21, 2018: Journal of Trace Elements in Medicine and Biology
Janet Trujillo, Matias Costa Vieira, Jaqueline Lepsch, Fernanda Rebelo, Lucilla Poston, Dharmintra Pasupathy, Gilberto Kac
BACKGROUND: Nutritional requirements need to be met in order to adapt to pre- and postnatal changes. Our aim was to systematically review the evidence of associations between nutritional biomarkers and psychological distress during pregnancy and in the first postnatal year. METHODS: MEDLINE, EMBASE, PsycINFO, Scielo, LILACS,, International Clinical Trials Registry, Cochrane Library, Scopus and Web of Science databases were searched for articles from inception to 4/15/2016...
February 15, 2018: Journal of Affective Disorders
F C Monteiro Júnior, N R Mandarino, E M Santos, A M Santos, J V Salgado, D J A Brito, B J L Salgado, J S Lages, G Castelo Branco, N Salgado Filho
Hypovitaminosis D has been identified as a possible new cardiovascular risk factor. However, the results of studies correlating serum vitamin D levels with markers of subclinical atherosclerosis have been conflicting. The aim of this study was to correlate serum levels of 25-hydroxyvitamin D [25(OH)D] with carotid intima-media thickness (C-IMT) and conventional cardiovascular risk factors in Afro-descendants. A cross-sectional analysis was performed on a sample of 382 individuals from a cohort of descendants of African slaves, inhabitants of "Quilombola" communities, with a mean age of 57...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Holly P Quach, Tamara Dzekic, Paola Bukuroshi, K Sandy Pang
Vitamin D3 and the synthetic vitamin D analogs, 1α-hydroxyvitamin D3 [1α(OH)D3 ] and 1α-hydroxyvitamin D2 [1α(OH)D2 ], and 25-hydroxyvitamin D3 [25(OH)D3 ] were appraised for their vitamin D receptor (VDR) associated-potencies as cholesterol lowering agents in mice in vivo. These precursors require activation in vivo: 1α(OH)D3 and 1α(OH)D2 are activated by liver Cyp2r1 and Cyp27a1 to active VDR ligands, 1α,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ] and 1α,25-dihydroxyvitamin D2 [1,25(OH)2 D2 ], respectively...
February 27, 2018: Biopharmaceutics & Drug Disposition
Mariana De Santis Filgueiras, Lara Gomes Suhett, Mariane Alves Silva, Naruna Pereira Rocha, Juliana Farias de Novaes
OBJECTIVE: To evaluate the association of vitamin D intake with dyslipidaemia and vitamin D insufficiency/deficiency in Brazilian children and identify the main food group sources of this nutrient in the sample. DESIGN: A cross-sectional study carried out with a representative sample. Blood was collected after 12 h of fasting. Laboratory tests were performed to determine total cholesterol, HDL cholesterol (HDL-C), LDL cholesterol, TAG, apoB, apoA1, 25-hydroxyvitamin D and parathyroid hormone...
February 26, 2018: Public Health Nutrition
Xiao Zhu, Yixuan Tu, Hainan Chen, Ampadu O Jackson, Vaibhav Patel, Kai Yin
BACKGROUND: The accumulation and pro-inflammatory polarization of immune cells, mainly macrophages, in adipose tissue (AT) are considered crucial factors for obesity-induced chronic inflammatory diseases. SCOPE OF REVIEW: In this review, we highlighted the role of adipose tissue macrophage (ATM) polarization on AT function in the obese state and the effect of the micro-environment and intracellular metabolism on the dynamic switch of ATMs into their pro-inflammatory or anti-inflammatory phenotypes, which may have distinct influences on obesity-related chronic inflammatory diseases...
February 23, 2018: Diabetes/metabolism Research and Reviews
Letícia de Paula Scalioni, Betânia Rodrigues Dos Santos, Poli Mara Spritzer, Cristiane Alves Villela-Nogueira, Lia Laura Lewis-Ximenez, Priscila Pollo-Flores, Eliane Bordalo Cathalá Esberard, Carlos Eduardo Brandão-Mello, Elisabeth Lampe, Livia Melo Villar
Potential relationship of vitamin D, vitamin D receptor (VDR), and vitamin D binding protein (DBP) have been suggested in the pathophysiology of hepatitis C virus (HCV) infection. The aim of this observational study is to determine vitamin D levels, and VDR and DBP genetic polymorphism according demographic and laboratory data in chronic HCV patients (CHC).A total of 148 CHC patients gave serum samples for testing 25-hydroxyvitamin D (25 (OH)D) level by immunochemiluminometric assay (<20 ng/mL defined as deficient) and donated blood samples to allelic discrimination analysis using TaqMan assays...
February 2018: Medicine (Baltimore)
Rolf Jorde, Guri Grimnes
BACKGROUND/OBJECTIVES: In observational, but not interventional, studies there are strong associations between serum 25-hydroxyvitamin D (25(OH)D) and serum lipids. The purpose of the present study was to examine potential causes of this association. SUBJECTS/METHODS: A total of 17,411 subjects participating in the seventh survey of the Tromsø Study were included in the cross-sectional study; 5384 subjects who participated in both the sixth and seventh survey were included in the longitudinal study; 2365 subjects who participated in both the fourth and seventh survey were included in the genetic study; and 479 subjects with impaired glucose tolerance were included in the vitamin D binding protein (DBP) analyses...
February 12, 2018: European Journal of Clinical Nutrition
Nasser M Al-Daghri, Mohammed Ghouse Ahmed Ansari, Shaun Sabico, Yousef Al-Saleh, Naji J Aljohani, Hanan Alfawaz, Mohammed Alharbi, Abdulaziz M Al-Othman, Majed S Alokail, Sunil J Wimalawansa
Vitamin D deficiency is rampant in the Middle East, even in children and adolescents. This study was designed to investigate the effects of different vitamin D repletion strategies commonly used on serum vitamin D levels of Saudi adolescents. STUDY DESIGN: A 6-month multi-center, controlled, clinical study, involving 34 schools in the central region of Riyadh, Saudi Arabia. Different strategies of vitamin D supplementation were tested (200 ml fortified milk of different brands or vitamin D tablet (1,000IU)...
February 9, 2018: Journal of Steroid Biochemistry and Molecular Biology
Fariba Raygan, Vahidreza Ostadmohammadi, Fereshteh Bahmani, Zatollah Asemi
BACKGROUND: This study was carried out to evaluate the effects of vitamin D and probiotic co-supplementation on mental health parameters and metabolic status in diabetic people with coronary heart disease (CHD). METHODS: This randomized, double-blind, placebo-controlled trial was carried out among 60 diabetic people with CHD, aged 45-85 years old. Subjects were randomly allocated into two groups to receive either 50,000 IU vitamin D every 2 weeks plus 8 × 10 9 CFU/g probiotic of Lactocare Zisttakhmir Co (n = 30) or placebo (n = 30) for 12 weeks...
February 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Baraa Alghalyini, Said El Shamieh, Ali Salami, Sophie Visvikis Siest, Hana M Fakhoury, Rajaa Fakhoury
Background Statin therapy used to lower cholesterol levels results in a substantial reduction in cardiovascular complications. Previous observations in different ethnic populations showed that rs2306283A>G, p.Asn130Asp and rs4149056T>C, p.Val174Ala in solute carrier organic anion transporter 1B1 (SLCO1B1) gene encoding the organic transporter protein may be responsible for statin uptake, thus explaining the majority of statin-associated symptoms. In addition to the genetic component, vitamin D (vit D) deficiency is common in Saudi Arabia and worldwide and may cause muscle dysfunction and ache...
February 8, 2018: Drug Metabolism and Personalized Therapy
M H Gannagé-Yared, R Sabbagh, R Chédid
PURPOSE: Limited information is available regarding the association of vitamin D and lipid profile in pediatric populations. The objective of this cross-sectional study is to determine the prevalence of vitamin D deficiency in a large sample of Lebanese schoolchildren and to evaluate the relationship between vitamin D and lipid profile. METHODS: 969 Lebanese schoolchildren (505 boys and 464 girls) aged 8-18 years were recruited from 10 schools of different socioeconomic status (SES)...
February 6, 2018: Journal of Endocrinological Investigation
Masoume Mansouri, Roshanak Abasi, Morteza Nasiri, Farshad Sharifi, Sedyghe Vesaly, Omid Sadeghi, Nayere Rahimi, Nasrin Akbary Sharif
AIM: We aimed to assess the association of vitamin D status with metabolic syndrome and its components among high educated Iranian adults. METHOD: In this cross-sectional study, 352 faculty members with age of 35 years or more, belong to Tarbiat Modares University, Tehran, Islamic Republic of Iran, were recruited during 2016 and 2017. Fasting blood samples were obtained to quantify serum 25(OH)D concentrations, glycemic indicators and lipid profile. Metabolic syndrome was defined based on the guidelines of the National Cholesterol Education Program Adult Treatment Panel III (ATP III)...
February 1, 2018: Diabetes & Metabolic Syndrome
Daniel Mønsted Shabanzadeh
Gallstone disease is highly prevalent in Denmark and other countries of northern Europe, and cholecystectomy for the treatment of clinical gallstone disease is one the most frequently performed surgical procedures. Research efforts for the identification of mechanisms involved in gallstone formation have a long history and the most established include bile cholesterol saturation, gallbladder motor function, and the enterohepatic circulation of secondary bile salts produced by fecal microbiota. A small number of determinants that are believed to affect these mechanisms have been identified until now...
February 2018: Danish Medical Journal
Marina B Pioltine, Maria Edna de Melo, Aritânia S Santos, Alisson D Machado, Ariana E Fernandes, Clarissa T Fujiwara, Cintia Cercato, Marcio C Mancini
Childhood obesity is a major public health problem. It has a direct impact on the quality of life of children and adolescents, as well as on their future risk of developing chronic diseases. Dietary patterns rich in fats and sugars and lacking dietary fibers, vitamins, and minerals, as well as lack of physical exercise have been associated with the rise of obesity prevalence. However, factors that contribute to the preference for foods rich in these nutrients are not well established. Taste is recognized as an important predictor of food choices, and polymorphisms in taste-related genes may explain the variability of taste preference and food intake...
January 29, 2018: Journal of Personalized Medicine
Manal Abudawood, Hajera Tabassum, Sabah Ansar, Khalid Almosa, Samia Sobki, Mir Naiman Ali, Ali Aljohi
Diabetes is a major risk factor for cardiovascular disease (CVD) including stroke, coronary heart disease, and peripheral artery disease. It remains a leading cause of mortality throughout the world, affecting both women and men. This investigation was aimed to study gender based differences in cardiovascular risk factors of adult population with type-2 diabetes mellitus (T2DM) and to check the correlation between serum HbA1C, lipid profile and serum vitamin D levels, in T2DM patients of Riyadh, Saudi Arabia...
January 2018: Saudi Journal of Biological Sciences
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