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Pseudoephedrine

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https://www.readbyqxmd.com/read/27925348/factors-associated-with-efficacy-of-an-ibuprofen-pseudoephedrine-combination-drug-in-pharmacy-customers%C3%A2-with-common-cold-symptoms
#1
Ludger Klimek, Helmut Schumacher, Tanja Schütt, Heidemarie Gräter, Tobias Mueck, Martin C Michel
AIM: The aim of this study was to explore factors affecting efficacy of treatment of common cold symptoms with an over-the-counter ibuprofen/pseudoephedrine combination product. METHODS: Data from an anonymous survey among 1770 pharmacy customers purchasing the combination product for treatment of own common cold symptoms underwent post-hoc descriptive analysis. Scores of symptoms typically responsive to ibuprofen (headache, pharyngeal pain, joint pain and fever), typically responsive to pseudoephedrine (congested nose, congested sinus and runny nose), considered non-specific (sneezing, fatigue, dry cough, cough with expectoration) and comprising all 11 symptoms were analysed...
December 7, 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27912193/comparative-tissue-distribution-and-excretion-study-of-alkaloids-from-herba-ephedrae-radix-aconiti-lateralis-extracts-in-rats
#2
Mengyue Ren, Shuai Song, Dedong Liang, Weiting Hou, Xiaomei Tan, Jiabo Luo
Herba Ephedrae-Radix Aconiti Lateralis, composed of Ephedrae (Mahuang in Chinese) and Radix Aconiti Lateralis (Fuzi in Chinese), is a classical herbal combination proven to be effective in treating common cold, asthma, and rheumatoid arthritis. Alkaloids, bioactive components of the herbal extract, have been associated with many side effects. Nine alkaloids, including norephedrine, norpseudoephedrine, ephedrine, pseudoephedrine, methylephedrine, hypaconitine, benzoylaconine, benzoylmesaconine and benzoylhypaconine, were simultaneously quantified within 14...
November 13, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27884871/simultaneous-liquid-chromatographic-determination-of-ebastine-with-two-sympathomimetic-drugs-using-a-monolithic-column
#3
F Ibrahim, M E K Wahba
Ebastine (EBS) has been assayed in its laboratory-prepared co-formulated tablets with either pseudoephedrine hydrochloride (PSU) or phenylephrine hydrochloride (PHR) using isocratic reversed-phase chromatography. Separation was conducted using a 50 mm × 4.6 mm i.d., Chromolith(®) SpeedROD RP-18 end-capped column at ambient temperature. A mobile phase composed of water:acetonitrile in a ratio of 25:75 having a pH of 3.2, has been utilized at 1 mL/min with UV detection at 254 nm for both EBS and PSU and 274 nm for PHR which in turn increased the sensitivity of the proposed method significantly...
November 24, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27851635/2001-pseudoephedrine-for-the-treatment-of-a-pregnant-patient-with-neurogenic-shock-a-case-report
#4
Caitlin Schaapveld-Davis, Adam Wiss, Adam Boucher, Joseph Swanson
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27846433/validated-quantification-method-for-five-ephedrines-in-dietary-supplements-using-lc-ms-ms-application-to-503-cases
#5
Jianli Zhang, Yinong Zhang, Yan Wang
Ephedrines in dietary supplements can arise from herbs or illegal adulteration so a liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for separation and quantification of ephedrine, pseudoephedrine, norephedrine, norepseudoephedrine, and methyl-ephedrine, some of which are isomer pairs of pseudo-structures. This method includes liquid-liquid extraction of ephedrines from three typical dietary supplement matrices-solid, liquid, and oil-as well as liquid chromatographic separation...
November 9, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27748955/nasal-decongestants-in-monotherapy-for-the-common-cold
#6
REVIEW
Laura Deckx, An Im De Sutter, Linda Guo, Nabiel A Mir, Mieke L van Driel
BACKGROUND: Many treatments for the common cold exist and are sold over-the-counter. Nevertheless, evidence on the effectiveness and safety of nasal decongestants is limited. OBJECTIVES: To assess the efficacy, and short- and long-term safety, of nasal decongestants used in monotherapy to alleviate symptoms of the common cold in adults and children. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL, Issue 6, June 2016), which contains the Cochrane Acute Respiratory Infections (ARI) Specialised Register, MEDLINE (1946 to July 2016), Embase (2010 to 15 July 2016), CINAHL (1981 to 15 July 2016), LILACS (1982 to July 2016), Web of Science (1955 to July 2016) and clinical trials registers...
October 17, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27741563/pharmaceutical-sales-of-pseudoephedrine-the-impact-of-electronic-tracking-systems-on-methamphetamine-crime-incidents
#7
Lorraine Mazerolle, Ingrid McGuffog, Jason Ferris, Mitchell B Chamlin
BACKGROUND AND AIMS: Electronic Tracking Systems (ETS) are used extensively in pharmacies across the US and Australia to control suspicious sales of pseudoephedrine. This study measures the impact of one ETS - Project STOP - on the capacity of police to reduce production, supply and possession of methamphetamine. DESIGN: Using official police data of incidents of production, supply and possession from January 1996 to December 2011 (N = 192 data points/months over 16 years), we used a quasi-experimental, time series approach...
October 14, 2016: Addiction
https://www.readbyqxmd.com/read/27662264/pharmacokinetics-of-guaifenesin-pseudoephedrine-and-hydrocodone-in-a-combination-oral-liquid-formulation-administered-as-single-and-multiple-doses-in-healthy-chinese-volunteers-and-comparison-with-data-for-individual-compounds-formulated-as-antuss-%C3%A2
#8
Shuhua Deng, Wencan Huang, Xiaojia Ni, Ming Zhang, Haoyang Lu, Zhanzhang Wang, Jinqing Hu, Xiuqing Zhu, Chang Qiu, Dewei Shang, Yuefeng Zhang, Linghui Xiong, Yuguan Wen
1. A new oral liquid formulation combining guaifenesin, pseudoephedrine and hydrocodone is effective in improving the symptoms of common cold. The pharmacokinetic properties of the individual components were evaluated in a randomized, open-label, 4-period study in 12 healthy Chinese volunteers following single and multiple doses. The data were compared with data for the individual ingredients in Antuss(®). 2. In the single-dose period, exposure levels (AUC and Cmax) for guaifenesin, pseudoephedrine and hydrocodone increased directly as the dose of the oral liquid formulation increased from 5 to 15 mL...
September 23, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/27652229/the-drug-treatment-of-delayed-ejaculation
#9
REVIEW
Ibrahim A Abdel-Hamid, Moustafa A Elsaied, Taymour Mostafa
Delayed ejaculation (DE) is an uncommon and a challenging disorder to treat. It is often quite concerning to patients and it can affect psychosocial well-being. Here we reviewed how DE is treated pharmacologically .We also highlighted specific settings where drugs could be introduced to medical practice. Electronic databases were searched from 1966 to February 2016, including PubMed MEDLINE, EMBASE, EBCSO Academic Search Complete, Cochrane Systematic Reviews Database, and Google Scholar using key words; delayed ejaculation, retarded ejaculation, inhibited ejaculation, drugs, treatment, or pharmacology...
August 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27645735/ionic-liquids-in-capillary-electrophoresis
#10
Ulrike Holzgrabe, Joachim Wahl
Recently, a great interest was drawn toward ionic liquids (ILs) in analytical separation techniques. ILs possess many properties making them excellent additives in capillary electrophoresis (CE) background electrolytes (BGE). The most important property is the charge of the dissolved ions in BGE enabling the cations to interact with deprotonated silanol groups on the capillary surface and thereby modifying the electroosmotic flow (EOF). Ionic and/or proton donor-acceptor interactions between analyte and IL are possible interactions facilitating new kinds of separation mechanisms in CE...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27577258/evaluation-of-pseudoephedrine-pharmacy-sales-before-and-after-mandatory-recording-requirements-in-western-australia-a-case-study
#11
Hendrika Laetitia Hattingh, Janki Varsani, Leila Ataei Kachouei, Richard Parsons
BACKGROUND: A community pharmacy real-time electronic recording program, ProjectSTOP, enables Australian community pharmacists to verify pseudoephedrine requests. In Western Australia the program was available for voluntary use from April 2007 and became mandatory November 2010. This case study explores the effectiveness of the program by reviewing the total requests for pseudoephedrine products, and the proportion of requests which were classified as 'denied sales' before and after mandatory implementation...
2016: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/27574107/identification-and-characterization-of-n-tert-butoxycarbonyl-mdma-a-new-mdma-precursor
#12
Michael Collins, Christopher Donnelly, Shane Cameron, Mark Tahtouh, Helen Salouros
In September 2015, eighty litres of a viscous, light-red liquid, described as hair product, was seized by the Australian Border Force (ABF). Initial testing by ABF indicated that the liquid was the MDMA precursor chemical safrole and custody of the material was transferred to the Australian Federal Police (AFP) who coordinated all subsequent investigations. Initial gas chromatography-mass spectrometry (GC-MS) analysis by AFP indicated that the material was not safrole and samples of the liquid were transferred to the National Measurement Institute Australia (NMIA) for identification...
August 30, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27529812/essential-precursor-chemicals-and-drug-consumption-impacts-of-us-sodium-permanganate-and-mexico-pseudoephedrine-controls-on-the-numbers-of-us-cocaine-and-methamphetamine-users
#13
James K Cunningham, Lon-Mu Liu, Russell C Callaghan
BACKGROUND AND AIMS: In December 2006 the United States regulated sodium permanganate, a cocaine essential chemical. In March 2007 Mexico, the United States' primary source for methamphetamine, closed a chemical company accused of illicitly importing 60+ tons of pseudoephedrine, a methamphetamine precursor chemical. US cocaine availability and methamphetamine availability, respectively, decreased in association. This study tested whether the controls had impacts upon the numbers of US cocaine users and methamphetamine users...
November 2016: Addiction
https://www.readbyqxmd.com/read/27514823/pharmacokinetic-effects-of-cinnamic-acid-amygdalin-glycyrrhizic-acid-and-liquiritin-on-ephedra-alkaloids-in-rats
#14
Yinghong Tang, Mengkai Zheng, Yu-Lin Chen, Jianzhen Chen, Yu He
BACKGROUND AND OBJECTIVES: Ephedra alkaloids, including ephedrine (EP), pseudoephedrine (PEP) and methylephedrine (MEP), are sympathomimetic compounds with known toxicities but many Ephedra (Ephedrae herba) preparations, such as Ephedra decoction, have been clinically applied for centuries. In order to explore the possible detoxification mechanism of Ephedra alkaloids, four representative compounds in Ephedra decoction (cinnamic acid, amygdalin, glycyrrhizic acid and liquiritin) were studied for their pharmacokinetic effects on Ephedra alkaloids in Sprague-Dawley rats...
August 11, 2016: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27486310/voiding-dysfunction-in-patients-with-nasal-congestion-treated-with-pseudoephedrine-a-prospective-study
#15
I-Hung Shao, Chia-Chen Wu, Hsiao-Jung Tseng, Ta-Jen Lee, Yu-Hsiang Lin, Yuan-Yun Tam
BACKGROUND: Pseudoephedrine is a sympathomimetic drug widely used as a nasal decongestant. However, it can cause adverse effects, such as voiding dysfunction. The risk of voiding dysfunction remains uncertain in patients without subjective voiding problems. METHODOLOGY: We prospectively enrolled patients with nasal congestion who required treatment with pseudoephedrine from May to August 2015. All patients denied concomitant subjective voiding problem. The International Prostate Symptom Score (IPSS) questionnaire was used to evaluate voiding function before and 1 week after the pseudoephedrine treatment...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27484247/in-silico-optimisation-of-two-dimensional-high-performance-liquid-chromatography-for-the-determination-of-australian-methamphetamine-seizure-samples
#16
Luke M Andrighetto, Niki K Burns, Paul G Stevenson, James R Pearson, Luke C Henderson, Christopher J Bowen, Xavier A Conlan
In-silico optimisation of a two-dimensional high performance liquid chromatography (2D-HPLC) separation protocol has been developed for the interrogation of methamphetamine samples including model, real world seizure, and laboratory synthesised samples. The protocol used Drylab(®) software to rapidly identify the optimum separation conditions from a library of chromatography columns. The optimum separation space was provided by the Phenomonex Kinetex PFP column (first dimension) and an Agilent Poroshell 120 EC-C18 column (second dimension)...
September 2016: Forensic Science International
https://www.readbyqxmd.com/read/27474946/esterification-of-pseudoephedrine-hydrochloride-by-citric-acid-in-a-solid-dose-pharmaceutical-preparation
#17
Alok Goel, Zhicheng Zhao, Dan Sørensen, Jay Zhou, Fa Zhang
Esterification of pseudoephedrine hydrochloride (PSE) by citric acid was observed in a solid dose pharmaceutical preparation at room temperature and accelerated stability condition (40°C/75% relative humidity). The esterification of PSE with citric acid was confirmed by a solid-state binary reaction in the presence of minor level of water at elevated temperature to generate three isomeric esters. The structures of the pseudoephedrine citric acid esters were elucidated using high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy (NMR)...
September 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27424504/the-acute-effect-of-pseudoephedrine-on-choroidal-thickness
#18
G Ovet, I Alpfidan, Y Sakarya, R Sakarya, M Ozcimen, S Göktaş, E Erdoğan
PURPOSE: To investigate the acute effects of pseudoephedrine (PE) on choroidal thickness in healthy young patients. METHODS: Fifty patients with nasal and sinus congestion who were prescribed 60 mg oral PE at the otolaryngology department were recruited for this study. The enhanced depth imaging (EDI) optic coherence tomography (OCT) (Spectralis OCT; Heidelberg Engineering, Heidelberg, Germany) choroidal thickness measurements were performed at baseline and 1, 3 and 6 hours at 7 points...
May 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/27405362/fatal-combination-with-3-methylmethcathinone-3-mmc-and-gamma-hydroxybutyric-acid-ghb
#19
Carole Jamey, Pascal Kintz, Laurent Martrille, Jean-Sébastien Raul
We reported the case of 69-year-old man who was discovered dead at a friend's home. 3-Methylmethcathinone (3-MMC) and poppers (alkyl nitrites) were found at the scene by the police. Autopsy specimens including peripheral and cardiac blood, urine, gastric content, bile and hair were sent to our laboratory to document a possible death involving abuse of drugs. Routine toxicological analysis was performed with gas chromatography with flame ionization detection (GC-FID), high performance liquid chromatography-diode array detection (HPLC-DAD), headspace gas chromatography-mass spectrometry (HS-GC-MS), gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS)-MS...
September 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27400480/correlation-between-the-transdermal-characteristics-of-pseudoephedrine-and-amygdalin-in-majiepingchuan-in-vitro
#20
COMPARATIVE STUDY
Hui Kong, Huihua Qu, Baoping Qu, Wenhao Zeng, Yan Zhao, Xueqian Wang, Qingguo Wang
OBJECTIVE: To analyze the transdermal profile of pseudoephedrine and amygdalin in the Traditional Chinese Medicine majiepingchuan in rat skin and to reveal their interaction. METHODS: A Franz diffusion cell was used in vitro to evaluate the transdermal parameters of cumulative transdermal flux (Q(tot)), cumulative transmission (T(tot)), and mean penetration rate (Kp) of pseudoephedrine and amygdalin in majiepingchuan. Linear regression analyses of Q(tot) over time of pseudoephedrine vs amygdalin and their ratios was adopted for correlation evaluation...
April 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
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