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https://www.readbyqxmd.com/read/29674401/licorice-induced-apparent-mineralocorticoid-excess-compounded-by-excessive-use-of-terbutaline-and-high-water-intake
#1
Laust Frisenberg Buhl, Frederik Nørregaard Pedersen, Marianne Skovsager Andersen, Dorte Glintborg
This case highlights the clinical course of a 54-year-old male patient presenting with hypertension and long-term refractory hypokalaemia. He reported long-term malaise, fatigue and physical discomfort. Diarrhoea, vomiting, over-the-counter drugs, dietary supplements and any kind of medical abuse were all denied. Physical examination was normal. Suppressed plasma renin activity along with a low aldosterone level and elevated urinary cortisone/cortisol metabolite excretion ratio raised the suspicion of apparent mineralocorticoid excess (AME)...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29671667/clinical-utility-of-marketing-terms-used-for-over-the-counter-dermatologic-products
#2
Emily Boozalis, Shivani Patel
BACKGROUND: Cosmetic products are commonly marketed using dermatologic terms such as "hypoallergenic," "non-comedogenic," "fragrance-free," etc. The clinical relevance of these claims can be confusing to both patients and clinicians. METHODS: A systematic review was performed from via a PubMed search of published articles from January 1985 to October 2017 to further describe and elucidate the clinical utility of a predefined list of common dermatologic terms used by pharmaceutical companies to market over the counter products...
April 19, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29671128/a-phase-i-study-of-the-pharmacokinetics-and-pharmacodynamics-of-intranasal-doxylamine-in-subjects-with-chronic-intermittent-sleep-impairment
#3
Mark Allison, Cecilia Hale
INTRODUCTION: Doxylamine tablets are approved as an over-the-counter sleep aid. We developed a doxylamine succinate intranasal metered-dose delivery system with the expectation of a more rapid onset of action with reduced side-effect potential compared with the oral tablet. METHODS: This phase I study randomized 24 adults with chronic intermittent sleep impairment to receive either single doses of intranasal doxylamine succinate 3.2, 6.3, or 12.7 mg or doxylamine succinate 25-mg oral tablet...
April 18, 2018: Drugs in R&D
https://www.readbyqxmd.com/read/29669663/nonprescription-medications-for-respiratory-symptoms-facts-and-marketing-fictions
#4
Miles Weinberger, Leslie Hendeles
BACKGROUND: There are many nonprescription (over-the-counter [OTC]) medications available on pharmacy shelves marketed for relief of respiratory symptoms. The number of such medications has been increasing. OBJECTIVE: This review provides an evidence-based examination of OTC products used for respiratory symptoms. METHODS: Antihistamines, decongestants, mucolytics, antitussives, and intranasal steroids were selected as the most common OTC medications taken by adults and children for various respiratory symptoms...
May 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29665654/hypericin-affects-cancer-side-populations-via-competitive-inhibition-of-bcrp
#5
Jana Vargová, Jaromír Mikeš, Rastislav Jendželovský, Lucia Mikešová, Barbora Kuchárová, Ľubomír Čulka, Radek Fedr, Ján Remšík, Karel Souček, Alois Kozubík, Peter Fedoročko
OBJECTIVE: Cancer stem-like cells (CSLCs) are considered a root of tumorigenicity and resistance. However, their identification remains challenging. The use of the side population (SP) assay as a credible marker of CSLCs remains controversial. The SP assay relies on the elevated activity of ABC transporters that, in turn, can be modulated by hypericin (HYP), a photosensitizer and bioactive compound of St. John's Wort (Hypericum perforatum), a popular over-the-counter antidepressant. Here we aimed to comprehensively characterize the SP phenotype of cancer cells and to determine the impact of HYP on these cells...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29643744/cost-effectiveness-of-the-recommended-medical-intervention-for-the-treatment-of-dysmenorrhea-and-endometriosis-in-japan
#6
Ichiro Arakawa, Mikio Momoeda, Yutaka Osuga, Ikuko Ota, Kaori Koga
Background and objective: This study aims to assess the cost-effectiveness of early physician consultation and guideline-based intervention to prevent endometriosis and/or disease progression using oral contraceptive (OC) and progestin compared to follow-up of self-care for dysmenorrhea in Japan. Methods: A yearly-transmitted Markov model of five major health states with four sub-medical states was constructed. Transition probabilities among health and medical states were derived from Japanese epidemiological patient surveys and converted to appropriate parameters for inputting into the model...
2018: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/29627667/electrochemical-study-of-acetaminophen-oxidation-by-gold-nanoparticles-supported-on-a-leaf-like-zeolitic-imidazolate-framework
#7
Lei Wang, Tianjiao Meng, Yanwei Fan, Chunxia Chen, Ziwei Guo, Huan Wang, Yufan Zhang
Decoration of leaf-like zeolitic imidazolate framework (ZIF-L) with Au nanoparticles (NPs) by a simple self-assembly method was described in this work. The materials were characterized by Fourier transform infrared spectroscopy, energy-dispersive X-ray spectra, N2 adsorption, and thermogravimetric analysis. Acetaminophen (AP) is most commonly referred to as an over-the-counter antipyretic and analgesic, which is a key factor in relieving fever and pain. It is particular significant to take efforts and conduct research for the development of reliable methods to detect the AP...
April 3, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29625706/pharmaceutical-cognitive-doping-in-students-a-chimeric-way-to-get-a-head
#8
Louise Carton, Nicolas Cabé, Olivier Ménard, Sylvie Deheul, Anne-Sylvie Caous, David Devos, Olivier Cottencin, Régis Bordet
For students, the pressing demands for memorization, top-level performance, and peer competition create an environment favorable for pharmaceutical cognitive doping behavior. We aimed to describe recent practices and the benefit/risk ratio of such behavior and to discuss the issues at stake. The prevalence of pharmaceutical cognitive doping among students has been reported from 1.3% to 33% across studies, with variations depending on country and definition of pharmaceutical cognitive doping. The therapeutic classes most frequently cited as being diverted for doping purposes are psychostimulants and nootropics (methylphenidate, modafinil, piracetam), corticosteroids, sedative drugs and beta-blockers...
March 6, 2018: Thérapie
https://www.readbyqxmd.com/read/29623687/qualitative-and-quantitative-detection-of-chicken-deoxyribonucleic-acid-dna-in-dry-dog-foods
#9
K Hołda, M Natonek-Wiśniewska, P Krzyścin, R Głogowski
Chicken is a common protein source in pet foods and is concurrently listed among food allergens. Commercial over-the-counter (OTC) diets with an alternative animal protein source are considered suitable for dietary elimination trials by pet owners. The potential presence of undeclared chicken-derived ingredients in these diets can compromise the outcome of the trial during the diagnosis of adverse food reactions. The aim of this study was to selectively verify the absence or presence of chicken DNA in 10 OTC dry canine foods, using qualitative and quantitative approaches...
April 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29622670/pharmacology-behind-common-drug-nephrotoxicities
#10
Mark A Perazella
Patients are exposed to numerous prescribed and over-the-counter medications. Unfortunately, drugs remain a relatively common cause of acute and chronic kidney injury. A combination of factors including the innate nephrotoxicity of drugs, underlying patient characteristics that increase their risk for kidney injury, and the metabolism and pathway of excretion by the kidneys of the various agents administered enhance risk for drug-induced nephrotoxicity. This paper will review these clinically relevant aspects of drug-induced nephrotoxicity for the clinical nephrologist...
April 5, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29621165/keeping-antibiotics-at-home-promotes-self-medication-with-antibiotics-among-chinese-university-students
#11
Xiaomin Wang, Leesa Lin, Ziming Xuan, Lu Li, Xudong Zhou
BACKGROUND: Inappropriate use of antibiotics has caused antimicrobial resistance, presenting a major health challenge to the world population. Self-medication with antibiotics (SMA) is currently at an alarming level in China. OBJECTIVES: To determine the sources of antibiotics leftover at home, the risk factors of keeping antibiotics at home, and the associations between keeping antibiotics at home and SMA among Chinese university students. METHODS: Six provinces were purposely selected from six regions of China, and one multi-disciplinary university was selected from each chosen province...
April 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29617381/prevention-of-colonic-neoplasia-with-polyethylene-glycol-a-short-term-randomized-placebo-controlled-double-blinded-trial
#12
Ramesh K Wali, Laura Bianchi, Sonia Kupfer, Mart De La Cruz, Borko Jovanovic, Christopher Weber, Michael J Goldberg, L M Rodriguez, Raymond Bergan, David Rubin, Mary Beth Tull, Ellen Richmond, Beth Parker, Seema Khan, Hemant K Roy
Chemoprevention represents an attractive modality against colorectal cancer (CRC) although widespread clinical implementation of promising agents (e.g. aspirin/NSAIDS) have been stymied by both suboptimal efficacy and concerns over toxicity. This highlights the need for better agents. Several groups, including our own, have reported that the over-the-counter laxative polyethylene glycol (PEG) has remarkable efficacy in rodent models of colon carcinogenesis. In this study, we undertook the first randomized human trial to address the role of PEG in prevention of human colonic neoplasia...
2018: PloS One
https://www.readbyqxmd.com/read/29615408/gps-retain-power-to-prescribe-over-the-counter-medicines
#13
Adrian O'Dowd
No abstract text is available yet for this article.
April 3, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29605475/evaluation-of-reported-contents-in-prescription-and-over-the-counter-prenatal-multivitamins
#14
Kelsey DeSalvo, Carol A Stamm, Laura M Borgelt
OBJECTIVES: To evaluate the reported amount of 14 vitamins and 10 minerals in over-the-counter (OTC) and prescription (Rx) prenatal multivitamins and minerals (PMVMs) and compare them to the Health and Medicine Division (HMD) of the National Academies recommended dietary allowances (RDAs) and tolerable upper intake levels for intake. DESIGN: Observational convenience sample of supplemental facts labels on OTC and Rx PMVMs identified and evaluated from online retailers, grocery stores, and pharmacies...
March 28, 2018: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29603865/randomized-clinical-study-of-alterations-in-the-color-and-surface-roughness-of-dental-enamel-brushed-with-whitening-toothpaste
#15
Lourenço de Moraes Rego Roselino, Camila Tirapelli, Fernanda de Carvalho Panzeri Pires-de-Souza
OBJECTIVES: This clinical study evaluated the influence of whitening toothpaste on color and surface roughness of dental enamel. MATERIALS AND METHODS: Initially, the abrasiveness of the toothpastes used (Sorriso Dentes Brancos [SDB]; Colgate Luminous White and Close up White Now) was tested on 30 (n = 10) plexiglass acrylic plates that were submitted to mechanical tooth brushing totalizing 29,200 cycles. Subsequently, 30 participants were selected, and received a toothbrush and nonwhitening toothpaste (SDB)...
March 30, 2018: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/29603073/predictors-of-self-medication-in-serbian-adult-population-cross-sectional-study
#16
Katica Tripković, Andjelija Nešković, Janko Janković, Marina Odalović
Background In spite of many benefits for individuals and community, self-medication has a number of potential risks. Objective To identify predictors of self-medication with over-the-counter and prescription (Rx) medicines without doctor's prescription. Setting Serbian population of 15 years of age and over. Method This was crosssectional, epidemiological study. Data have been drawn from Serbian National Health Survey 2013 database. Predictors of self-medication were determined among sociodemographic, health related and health services related factors, using multivariate logistic regression models...
March 30, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29602278/dark-classics-in-chemical-neuroscience-methamphetamine
#17
Thomas J Abbruscato, Paul C Trippier
Methamphetamine has the second highest prevalence of drug abuse after cannabis, with estimates of 35 million users worldwide. The (S)-(+)-enantiomer is the illicit drug, active neurostimulant and eutomer, while the (R)-(-)-enantiomer is contained in over the counter decongestants. While designated a schedule II drug in 1970, (S)-(+)-methamphetamine is available by prescription for the treatment of attention-deficit disorder and obesity. The illicit use of (S)-(+)-methamphetamine results in the sudden 'rush' of stimulation to the motivation, movement, pleasure and reward centers in the brain, caused by rapid release of dopamine...
March 30, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29602180/what-where-and-when-using-google-trends-and-google-to-investigate-patient-needs-and-inform-pharmacy-practice
#18
Alan Hanna, Lezley-Anne Hanna
OBJECTIVES: The aim was to provide a comprehensive overview (using pertinent examples) of the various ways that Google Trends and Google data could inform pharmacy practice. The objectives were to: examine what type of information people search for in relation to a common class of medicines; ascertain where people are directed to (websites) following an initial search for a medicine or medical condition; and establish information about when they search. METHODS: The methodology differed depending on whether Google Trends or Google was being interrogated, but the search domain was always limited to the United Kingdom...
March 30, 2018: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29601615/understanding-patient-experience-with-hyperhidrosis-a-national-survey-of-1-985-patients
#19
Dee Anna Glaser, Adelaide Hebert, Lisa Pieretti, David Pariser
Hyperhidrosis affects 4.8% of the US population, and despite the well documented negative impact of hyperhidrosis on patients' lives, data are generally lacking on the patient experience with this condition. The International Hyperhidrosis Society (IHHS) conducted a study in 2014, and initial results confirmed the multifaceted impact of hyperhidrosis on quality of life and underscored the need for disease awareness and effective management. To provide further insight into the hyperhidrosis patient experience, additional results focusing on family history, physician interaction, impact on daily activities, and treatment satisfaction are presented here...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29600877/interference-assessment-of-various-endogenous-and-exogenous-substances-on-the-performance-of-the-eversense-long-term-implantable-continuous-glucose-monitoring-system
#20
Carrie Lorenz, Wendolyn Sandoval, Mark Mortellaro
BACKGROUND: A variety of prescriptions and over-the-counter medications interfere with transcutaneous continuous glucose monitoring (CGM) sensors. This study characterized the interference profile of the Eversense® CGM System (Senseonics, Inc., Germantown, MD), which has a different mechanism of glucose detection than other CGM systems. MATERIALS AND METHODS: Sensor bias (sensor glucose concentration measurement - plasma glucose concentration measured by a reference test) was measured in vitro against 41 different substances at supratherapeutic/supraphysiologic plasma concentrations...
March 30, 2018: Diabetes Technology & Therapeutics
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