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https://www.readbyqxmd.com/read/27913785/safety-assessment-of-alumina-and-aluminum-hydroxide-as-used-in-cosmetics
#1
Lillian C Becker, Ivan Boyer, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
This is a safety assessment of alumina and aluminum hydroxide as used in cosmetics. Alumina functions as an abrasive, absorbent, anticaking agent, bulking agent, and opacifying agent. Aluminum hydroxide functions as a buffering agent, corrosion inhibitor, and pH adjuster. The Food and Drug Administration (FDA) evaluated the safe use of alumina in several medical devices and aluminum hydroxide in over-the-counter drugs, which included a review of human and animal safety data. The Cosmetic Ingredient Review (CIR) Expert Panel considered the FDA evaluations as part of the basis for determining the safety of these ingredients as used in cosmetics...
November 2016: International Journal of Toxicology
https://www.readbyqxmd.com/read/27910725/an-over-the-counter-central-sensitization-therapy-a-chronic-back-pain-registry-study-of-pain-relief-medication-use-and-their-adverse-effects
#2
Richard Staelin, Sree N Koneru, Ian M Rawe
AIM: Back pain, the most prevalent musculoskeletal chronic pain condition, is usually treated with analgesic medications of questionable efficacy and frequent occurrence of adverse side effects. OBJECTIVE: The objective was to determine the effectiveness of the ActiPatch medical devices in reducing chronic back pain, document medication related adverse side effects and establish their impact on quality of life. METHODS: Upon completing a 7-day trial, subjects were contacted via email with an assessment form using the Constant Contact email program...
December 2, 2016: Pain Management
https://www.readbyqxmd.com/read/27906534/food-and-drug-administration-review-and-action-on-over-the-counter-time-and-extent-applications-final-rule
#3
(no author information available yet)
The Food and Drug Administration (FDA or Agency) is amending its nonprescription (over-the-counter or OTC) drug regulations. This final rule supplements the time and extent application (TEA) process for OTC drugs by establishing timelines and performance metrics for FDA's review of non-sunscreen TEAs, as required by the Sunscreen Innovation Act (SIA). It also amends the existing TEA process to include filing determination and withdrawal provisions to make the TEA process more efficient.
November 23, 2016: Federal Register
https://www.readbyqxmd.com/read/27905078/improving-the-provision-of-otc-medication-information-in-community-pharmacies-in-poland
#4
Anna Piecuch, Magdalena Makarewicz-Wujec, Małgorzata Kozłowska-Wojciechowska
Background An informed or shared decision-making model is desirable to support the choice of over-the-counter (OTC) medications in pharmacies: it respects patient empowerment in self-medication. Such a model is achievable provided that pharmacists are a credible, competent information source open to patient needs. Objective To study the dependencies among selected factors that may influence the provision of OTC medication information. The study was conducted from the perspective of a community pharmacist. Method The study consisted of an auditorium survey with a self-administered questionnaire...
November 30, 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27904748/patterns-of-medication-use-and-factors-associated-with-antibiotic-use-among-adult-fever-patients-at-singapore-primary-care-clinics
#5
Zaw Myo Tun, Mahesh Moorthy, Martin Linster, Yvonne C F Su, Richard James Coker, Eng Eong Ooi, Jenny Guek-Hong Low, Gavin J D Smith, Clarence C Tam
BACKGROUND: Antimicrobial resistance is a public health problem of global importance. In Singapore, much focus has been given to antibiotic usage patterns in hospital settings. Data on antibiotic use in primary care is lacking. We describe antibiotic usage patterns and assess factors contributing to antibiotic usage among adults presenting with acute febrile illness (AFI) in primary care settings in Singapore. METHODS: We analyzed data from the Early Dengue infection and outcome study...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27901207/in-vitro-and-in-vivo-evaluation-of-nano-based-films-for-buccal-delivery-of-zolpidem
#6
Bandar Essa Al-Dhubiab
Insomnia is becoming increasingly prevalent in the world general population. Therapies used by patients include over-the-counter therapies, herbal and dietary supplements, and pharmacological or nonpharmacological treatments. Among these, zolpidem is a pharmacological treatment popularly used for insomnia. Zolpidem is well tolerated and especially efficacious for initiation of sleep, and therefore is effective for the treatment of sleep-onset insomnia. The purpose of the present study was to design and evaluate zolpidem nanoparticle-impregnated buccal films to prolong the duration of its action...
November 28, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27900921/-a-fixed-drug-eruption-caused-by-paracetamol
#7
L van Zogchel, T Hendriks, S Adriaens, I Diederen, E Herremans
BACKGROUND: Fixed drug eruption is a hypersensitive skin response to drugs, which can present itself in different ways. The skin lesions are usually solitary, but can also appear as a maculopapular rash, Stevens-Johnson syndrome or toxic epidermal necrolysis. While fixed drug eruptions can be caused by various drugs, paracetamol is responsible in 1.5% of cases. CASE DESCRIPTION: A 58-year-old man was seen in general practice with a five-year-old exanthema on his torso, arms and legs...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27897111/aggressive-antioxidant-reductive-stress-impairs-brain-endothelial-cell-angiogenesis-and-blood-brain-barrier-function
#8
Shireen Mentor, David Fisher
Oxidative stress in the brain microvasculature is a common characteristic in models of cerebrovascular disease. Considering the effects of reactive oxygen species activity in vascular-derived insults, it is naturally prudent to hypothesize those interventions inhibiting reactive oxygen species activity, such as antioxidant supplementation, may be beneficial for cerebrovascular disease. Hyper doses of antioxidant supplements, and foods with high antioxidant concentrations, are commonly used as an ongoing remedial and 'over-the-counter' treatments for most seasonal ailments...
November 29, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27891455/unmasking-the-effect-of-analgesics-on-endodontic-diagnosis-using-a-novel-bite-force-sensor-device-a-prospective-randomized-clinical-trial
#9
Sushil Kishnani, Suparna Ganguly Saha, Anuj Bhardwaj, Sandeep Dubey, Mainak Saha, Shubham Kala, Sohini Jain, Shweta Narwani
INTRODUCTION: A definitive diagnosis is of primary importance before initiating any endodontic treatment; yet, there are occasions when the dental professional is unable to accurately reproduce the patient's chief complaint, as it can pose a dilemma and may require consideration of multiple variables in order to reach an accurate diagnosis. So to overcome this problem, a methodical approach in providing endodontic treatment should be implemented which includes diagnosis, definitive dental treatment and adjunctive drug therapy, known as the "3D" strategy...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890543/hearing-care-intervention-for-persons-with-dementia-a-pilot-study
#10
Sara K Mamo, Olivia Nirmalasari, Carrie L Nieman, Matthew K McNabney, Allison Simpson, Esther S Oh, Frank R Lin
OBJECTIVE: Hearing loss is a commonly unmet need among adults with dementia that may exacerbate common dementia-related behavioral symptoms. Accessing traditional audiology services for hearing loss is a challenge because of high cost and time commitment. To improve accessibility and affordability of hearing treatment for persons with dementia, there is a need for unique service delivery models. The purpose of this study is to test a novel hearing intervention for persons with dementia and family caregivers delivered in outpatient settings...
September 22, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27890394/purchase-habits-use-of-paracetamol-and-information-sources-on-a-reregulated-swedish-pharmacy-market-a-population-based-study
#11
T Hedenrud, H Håkonsen
Considering the general lack of knowledge on how over-the-counter paracetamol is used combined with the reported increase in paracetamol poisonings after the reregulation of the Swedish pharmacy market in 2009, we aimed to analyze purchase habits and use of paracetamol in Sweden. A further aim was to investigate sources of information about paracetamol. Data were collected in October 2015 through the Citizen Panel, a Web-based panel encompassing over 50,000 Swedes. A stratified sample of 6000 (aged 18 years and older) was emailed a survey invitation...
November 19, 2016: Health Policy
https://www.readbyqxmd.com/read/27889404/adolescent-suicidal-ingestion-national-trends-over-a-decade
#12
David C Sheridan, Robert G Hendrickson, Amber L Lin, Rongwei Fu, B Zane Horowitz
PURPOSE: Suicide attempts by adolescents most commonly involve the overdose of medications. To date, there has been little information on the over-the-counter or prescription medicines that adolescents ingest for self-harm. Identification of medications chosen in suicide attempts may help guide anticipatory guidance to parents by primary care providers and Poison Centers in prevention programs. METHODS: This was a retrospective observational study using the American Association of Poison Control Center's National Poison Data System...
November 23, 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/27881100/high-prevalence-of-non-steroidal-anti-inflammatory-drug-use-among-acute-kidney-injury-survivors-in-the-southern-community-cohort-study
#13
Loren Lipworth, Khaled Abdel-Kader, Jennifer Morse, Thomas G Stewart, Edmond K Kabagambe, Sharidan K Parr, Kelly A Birdwell, Michael E Matheny, Adriana M Hung, William J Blot, T Alp Ikizler, Edward D Siew
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and have been linked to acute kidney injury (AKI), chronic kidney disease (CKD) and cardiovascular disease (CVD). Patients who survive an AKI episode are at risk for future adverse kidney and cardiovascular outcomes. The objective of our study was to examine the prevalence and predictors of NSAID use among AKI survivors. METHODS: The Southern Community Cohort Study is a prospective study of low-income adults aged 40-79 in the southeastern US...
November 24, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27879965/a-therapeutic-approach-to-paediatric-oral-disorders
#14
Enrico Calcagno, Dionisio F Barattini, Roberto Servetto
The promotion of oral health in paediatrics stands as an institutional requirement in countries such as Italy where children's dental disorders still register a high incidence in spite of high levels of general health. Guidelines indicate the need to target a large age group and stress the relevance of parental education, whom paediatricians and dentists should address to. In this respect, teething is paradigmatic, due to the interactions between inflammation of the gingival mucosa, the possible associations with systemic symptoms as well as the psychological parental component...
November 23, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27875056/opioid-nsaid-and-otc-analgesic-medications-for-dental-procedures-pearl-network-findings
#15
Ying Jo Wong, James Keenan, Keith Hudson, Henry Bryan, Frederick Naftolin, Van P Thompson, Ronald G Craig, Don Vena, Damon Collie, Hongyu Wu, Abigail G Matthews, Ashley C Grill, Frederick A Curro
OBJECTIVE: Dental treatment is often categorized as a moderately or severely painful experience; however, no clinical data reported by the patient and dentist currently exists to support this degree of pain. This has contributed possibly to the overprescribing of analgesics, in particular the opioid class of medications. The primary objective of the study was to document the dentists' postprocedural prescriptions and recommendations for analgesic medications and their effectiveness for a 5-day period...
November 2016: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/27866183/resolution-of-allergic-rhinitis-and-reactive-bronchospasm-with-supplements-and-food-specific-immunoglobulin-g-elimination-a-case-report
#16
Laura Kwiatkowski, Jessica Mitchell, Jeffrey Langland
Context • Allergies are a common affliction, whether they are respiratory, food related, or dermatological. People often resort to continuous use of over-the-counter medications, such as antihistamines, to manage their symptoms. Controversy still remains over testing serum immunoglobulin (Ig) G to diagnose food allergies. Objective • This study intended to examine the benefits of treatment of a pediatric patient with natural supplements and an elimination diet for IgG food allergies. Design • The research team reported a case study...
October 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/27865356/temporal-trends-in-dietary-supplement-prescriptions-of-united-states-military-service-members-suggest-a-decrease-in-pyridoxine-and-increase-in-vitamin-d-supplements-from-2005-to-2013
#17
Joseph J Knapik, Rosenie T Jean, Krista G Austin, Ryan A Steelman, Julia Gannon, Emily K Farina, Harris R Lieberman
Dietary supplements (DSs) can be obtained over-the-counter but can also be prescribed by health-care providers for therapeutic reasons. Few studies have documented this later source despite the fact that 79% of physicians and 82% of nurses have recommended DSs to patients. This investigation assessed prevalence and temporal trends in oral DS prescriptions filled by all United States service members (SMs) from 2005 to 2013 (n = 1 427 080 ± 22 139, mean ± standard deviation (SD)/y). We hypothesize that there would be temporal variations in specific types of DSs...
October 2016: Nutrition Research
https://www.readbyqxmd.com/read/27865294/overuse-and-misperceptions-of-nonsteroidal-anti-inflammatory-drugs-in-the-united-states
#18
Byron Cryer, Michael A Barnett, Jennifer Wagner, C Mel Wilcox
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are some of the most commonly used medications worldwide. The availability of hundreds of products containing an NSAID, combined with a lack of recognition and understanding of NSAIDs, can increase the potential of consumers to inadvertently exceed the recommended NSAID dosage, which can cause potentially serious side effects. Physician and consumer education regarding the appropriate use of NSAIDs can help prevent NSAID misuse...
November 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27855148/notes-from-the-field-cardiac-dysrhythmias-after-loperamide-abuse-new-york-2008-2016
#19
William Eggleston, Jeanna M Marraffa, Christine M Stork, Maria Mercurio-Zappala, Mark K Su, Rachel S Wightman, Karen R Cummings, Joshua G Schier
Loperamide is an over-the-counter antidiarrheal with opioid-receptor agonist properties. Recommended over-the-counter doses (range = 2-8 mg daily) do not produce opioid effects in the central nervous system because of poor oral bioavailability and P-glycoprotein efflux* of the medication (1); recent reports suggest that large doses (50-300 mg) of loperamide produce euphoria, central nervous system depression, and cardiotoxicity (2-4). Abuse of loperamide for its euphoric effect or for self-treatment of opioid withdrawal is increasing (5)...
November 18, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27849273/use-of-prescription-drugs-and-self-medication-among-men
#20
Maria Aparecida Medeiros Barros do Prado, Priscila Maria Stolses Bergamo Francisco, Tássia Fraga Bastos, Marilisa Berti de Azevedo Barros
Objective: To estimate the prevalence, investigate factors associated with the use of medication according to prescription, identify the main pharmaceuticals consumed through self-medication, and the reason for this use among adult men. Methods: This cross-sectional population-based study with stratified clustered two-stage sampling was conducted in Campinas, São Paulo, Brazil, in 2008/2009. Results: Of the 1,063 men, 45.3% reported using at least 1 drug in the last 3 days...
July 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
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