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https://www.readbyqxmd.com/read/29218681/management-strategies-to-facilitate-optimal-outcomes-for-patients-treated-with-delayed-release-dimethyl-fumarate
#1
Lori Mayer, Mary Kay Fink, Carrie Sammarco, Lisa Laing
Delayed-release dimethyl fumarate is an oral disease-modifying therapy that has demonstrated significant efficacy in adults with relapsing-remitting multiple sclerosis. Incidences of flushing and gastrointestinal adverse events are common in the first month after delayed-release dimethyl fumarate initiation. Our objective was to propose mitigation strategies for adverse events related to initiation of delayed-release dimethyl fumarate in the treatment of patients with multiple sclerosis. Studies of individually developed mitigation strategies and chart reviews were evaluated...
December 7, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29211054/barriers-and-facilitators-for-information-exchange-during-over-the-counter-consultations-in-community-pharmacy-a-focus-group-study
#2
Liza J Seubert, Kerry Whitelaw, Fabienne Boeni, Laetitia Hattingh, Margaret C Watson, Rhonda M Clifford
Consumers are confident managing minor ailments through self-care, often self-medicating from a range of over-the-counter (OTC) medicines available from community pharmacies. To minimise risks, pharmacy personnel endeavour to engage in a consultation when consumers present with OTC enquiries however they find consumers resistant. The aim was to determine stakeholder perspectives regarding barriers and facilitators for information exchange during OTC consultations in community pharmacies and to understand the elicited themes in behavioural terms...
December 6, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29201385/identifying-the-hidden-burden-of-allergic-rhinitis-ar-in-community-pharmacy-a-global-phenomenon
#3
Rachel Tan, Biljana Cvetkovski, Vicky Kritikos, David Price, Kwok Yan, Pete Smith, Sinthia Bosnic-Anticevich
Background: Patients with allergic rhinitis often trivialise their condition, self-manage inappropriately, and would benefit from health care intervention. The primary point of health care contact for these self-managing allergic rhinitis patients is the community pharmacy. With the majority of allergic rhinitis treatments being available for purchase over the counter, without health care professional contact, we know little about how the patients self-manage. This study aims to identify the burden of allergic rhinitis in the community pharmacy and to identify key opportunity for intervention...
2017: Asthma Research and Practice
https://www.readbyqxmd.com/read/29201368/medication-use-and-falls-applying-beers-criteria-to-medication-review-in-parkinson-s-disease
#4
Eleanor Yusupov, Davina Chen, Bhuma Krishnamachari
Objectives: Our goal was to assess the association between potentially inappropriate medication use and risk of falls in the Parkinson's disease population. Methods: This was a retrospective cohort study conducted at an outpatient Parkinson's Disease Treatment Center. Individuals 65 years of age or older, diagnosed with Parkinson's disease who attended at least three visits in 2015 for physical, occupational therapy, or physician's visits were included in the study...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/29199172/when-proton-pump-inhibitors-are-compared-are-there-specific-cases-in-which-a-certain-proton-pump-inhibitors-should-be-particularly-preferred
#5
Altay Çelebi, Hasan Yılmaz
Currently, proton pump inhibitors (PPIs) are widely used either over the counter or on prescription drugs. PPI's are frequently used with other drugs when elderly and chronic desease burden population is taken to consideration. Drug interactions with PPIs are a prominent clinical problem in this direction. In this study, we reviewed potential risks of concomittant use of PPIs and other drugs and apropriate PPI choise.
December 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29198079/thromboxane-inhibition-during-concurrent-therapy-with-low-dose-aspirin-and-over-the-counter-naproxen-sodium
#6
Paul A Gurbel, Kevin P Bliden, Junhong Zhu, Emanuel Troullos, Robert Centofanti, Sistine Jarvis, Palak Venkataraman, Udaya S Tantry
Aspirin is the dominant antiplatelet therapy for cardiovascular disease. Naproxen is frequently used in aspirin-treated patients and may influence the antiplatelet effect of aspirin. We evaluated the pharmacodynamic interaction (lower bound of the one-sided 95% CI for serum TxB2 inhibition < 95%) between 220 mg immediate-release naproxen sodium (once or twice daily) and 81 mg daily immediate release aspirin at various dosing intervals. There was no interaction during the first day of concurrent treatment...
December 2, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29194802/acne-across-europe-an-online-survey-on-perceptions-and-management-of-acne
#7
J C Szepietowski, P Wolkenstein, S Veraldi, D Tennstedt, A Machovcová, A Delarue
BACKGROUND: Acne is common among young people. OBJECTIVE: To describe the burden, management and sources of advice, of acne in a representative sample of young people in Europe. METHODS: This cross-sectional survey was conducted in a representative sample of individuals aged 15-24 years from Belgium, Czech and Slovak Republics, France, Italy, Poland and Spain (n=3099). RESULTS: Most individuals considered their acne (all severity stages) to be no/minor problem, although 29...
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29188694/supra-therapeutic-oral-paracetamol-overdose-in-adults-an-update-for-the-dental-team
#8
Ross Leader, James Hackett, Ahmed Al-Naher
Paracetamol (acetaminophen) is a commonly used analgesic; its 'over the counter' availability, low cost and popularity amongst patients often make it the first choice for dental pain. It is in this that its potential toxicity, made more complicated by the ever extending range of paracetamol-containing products, make the understanding of this medication key to the safe management of patients presenting to surgery with dental pain. Clinical relevance: The purpose of this article is to supply dental practitioners with the knowledge to manage patients who present having taken an oral supra-therapeutic paracetamol overdose...
May 2017: Dental Update
https://www.readbyqxmd.com/read/29185840/single-dose-levonorgestrel-emergency-contraception-and-silent-barriers-to-its-access-is-it-really-just-one-step
#9
Amanda H Ritter, Christine R Isaacs, Stephanie M Lee, Alan J Lee
BACKGROUND: Single-dose levonorgestrel has been legally available over the counter in the United States without age restriction since 2013. The objective of this study was to discover if there are barriers to access and to determine if such barriers vary based on the gender of the person making the purchase. MATERIALS AND METHODS: A male and female caller contacted 146 Richmond, Virginia pharmacies listed on the Plan B One Step® website. Ultimately, these callers interviewed 90 pharmacies via phone and used a rehearsed standardized script to ask eight questions regarding emergency contraception (EC) in relation to availability, age restrictions, parental consent, counseling requirements, and a male's ability to purchase the product...
November 29, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29179644/frequency-and-severity-of-potential-drug-interactions-in-a-cohort-of-hiv-infected-patients-identified-through-a-multidisciplinary-team
#10
E Molas, S Luque, A Retamero, D Echeverría-Esnal, A Guelar, M Montero, R Guerri, L Sorli, E Lerma, J Villar, H Knobel
OBJECTIVES: Interactions between antiretroviral treatment (ART) and comedications are a concern in HIV-infected patients. This study aimed to determine the frequency and severity of potential drug-drug interactions (PDDIs) with ART in our setting. METHODS: Observational study by a multidisciplinary team in 1259 consecutive HIV patients (March 2015-September 2016). Data on demographics, toxic habits, comorbidities, and current ART were collected. A structured questionnaire recorded concomitant medications (including occasional and over-the-counter drugs)...
November 28, 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/29178855/prices-of-over-the-counter-drugs-used-by-15-year-old-adolescents-in-germany-and-their-association-with-socioeconomic-background
#11
Salvatore Italia, Silke B Wolfenstetter, Irene Brüske, Joachim Heinrich, Dietrich Berdel, Andrea von Berg, Irina Lehmann, Marie Standl, Christina M Teuner
BACKGROUND: In Germany, over-the-counter (OTC) drugs are normally reimbursed up to the age of 12 years only. The aim of this study was to analyse prices of over-the-counter drugs used by adolescents in Germany and their association with socioeconomic factors. METHODS: Based on the German GINIplus and LISAplus birth cohorts, data on drug utilization among 15-year-old adolescents (n = 4677) were collected using a self-administered questionnaire. The reported drugs were subdivided into prescription drugs and OTC drugs...
November 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29170334/37%C3%A2-routine-testing-of-salicylate-levels-in-overdose-patients-still-needed
#12
Elaine Hardy, Clare Toro, Susan Dorrian, Umesh Salanke
INTRODUCTION AND AIMS: Overdose is a common presentation in Emergency Departments (EDs) across the UK. Salicylate poisoning is potentially fatal; however it is becoming increasingly uncommon in the UK. This may be due to restriction of pack sizes in over the counter medicines as well as the use of aspirin as an analgesic being superseded by other NSAIDs, particularly ibuprofen.In conjunction with clinical features of salicylate toxicity, measurement of plasma salicylate concentration can help guide management...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29167598/the-relationship-between-birch-pollen-air-pollution-and-weather-types-and-their-effect-on-antihistamine-purchase-in-two-swedish-cities
#13
Maria Grundström, Åslög Dahl, Tinghai Ou, Deliang Chen, Håkan Pleijel
Exposure to elevated air pollution levels can aggravate pollen allergy symptoms. The aim of this study was to investigate the relationships between airborne birch (Betula) pollen, urban air pollutants NO2, O3 and PM10 and their effects on antihistamine demand in Gothenburg and Malmö, Sweden, 2006-2012. Further, the influence of large-scale weather pattern on pollen-/pollution-related risk, using Lamb weather types (LWTs), was analysed. Daily LWTs were obtained by comparing the atmospheric pressure over a 16-point grid system over southern Sweden (scale ~3000 km)...
2017: Aerobiologia
https://www.readbyqxmd.com/read/29164274/detection-and-sizing-of-ti-containing-particles-in-recreational-waters-using-single-particle-icp-ms
#14
Arjun K Venkatesan, Robert B Reed, Sungyun Lee, Xiangyu Bi, David Hanigan, Yu Yang, James F Ranville, Pierre Herckes, Paul Westerhoff
Single particle inductively coupled plasma mass spectrometry (spICP-MS) was used to detect Ti-containing particles in heavily-used bathing areas of a river (Salt River) and five swimming pools. Ti-containing particle concentrations in swimming pools ranged from 2.8 × 10(3) to 4.4 × 10(3) particles/mL and were an order of magnitude lower than those detected in the Salt River. Measurements from the Salt River showed an 80% increase in Ti-containing particle concentration over baseline concentration during peak recreational activity (at 16:00 h) in the river...
November 21, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29163414/control-of-antimicrobial-resistance-requires-an-ethical-approach
#15
REVIEW
Ben Parsonage, Philip K Hagglund, Lloyd Keogh, Nick Wheelhouse, Richard E Brown, Stephanie J Dancer
Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the prospect of declining anti-infectives affects everyone. Without preventive action, loss of drugs that have saved lives over the past century, will condemn ourselves, people we know, and people we don't know, to unacceptable risk of untreatable infection. Policies aimed at extending antimicrobial life should be considered within an ethical framework, in order to balance the choice, range, and quality of drugs against stewardship activities...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29158721/knowledge-of-community-pharmacists-about-the-risks-of-medication-use-during-pregnancy-in-central-region-of-saudi-arabia
#16
Ziyad Alrabiah, Mohamed N Al-Arifi, Sultan M Alghadeer, Syed Wajid, Ali AlQahtani, Naif Almotari, AbdAllh AlHwerani, Salmeen D Babelghaith
Background: Community pharmacists (CPs) are the most accessible health care provider to the public, and they have huge duties to improve medication use especially among the pregnant women in their community. The objective of this study was to evaluate knowledge of CPs about the medication safety during pregnancy. Methods: A prospective cross-sectional survey was carried out over practicing community pharmacists in a capital of Saudi Arabia (SA). Pharmacists were asked about the safety of each medicine during pregnancy...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29157343/cross-sectional-analysis-of-commonly-prescribed-medications-in-military-aviation
#17
Lincoln G Ropp, Sean P Haight, Michael B Prudhomme, Elizabeth L Ropp
BACKGROUND: Medication use by naval aviators, either prescription or over-the-counter, is not always relayed to the flight surgeon, resulting in unsafe flying environments. Many medications have debilitating effects that prohibit their use during aviation. Education and availability of resources on approved medications for flight status personnel is lacking. METHODS: A retrospective search of the Department of Defense Composite Health Care System (DoD CHCS) was conducted from five geographic locations...
December 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29153854/what-are-pharmacists-recommending-for-infant-teething-treatment
#18
Eric J Ip, Punam B Patel, Josephine J Chi, Bijal Shah-Manek, Bonnie Lau
OBJECTIVES: In 2011, the Food and Drug Administration issued a warning to avoid the use of any benzocaine-containing products for infant teething treatment owing to a risk of methemoglobinemia. Several benzocaine-containing products targeted for infant teething are currently available over the counter. Pharmacists are commonly asked for medical advice in the community, and there is no current literature evaluating what pharmacists are recommending for infant teething. The objectives of this study were to evaluate what pharmacists are currently recommending for infant teething treatment and assess what percentage would inappropriately recommend a benzocaine-containing product...
November 15, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29147630/sulforaphane-from-broccoli-reduces-symptoms-of-autism-a-follow-up-case-series-from-a-randomized-double-blind-study
#19
Rhoda Lynch, Eileen L Diggins, Susan L Connors, Andrew W Zimmerman, Kanwaljit Singh, Hua Liu, Paul Talalay, Jed W Fahey
Introduction: Autism spectrum disorder (ASD) affects 1 in 68 children, is characterized by impaired social interaction and communication as well as restricted or repetitive behaviors, and varies widely with respect to its causes and presentations. There are no validated pharmacologic treatments for the core symptoms of ASD. The social, medical, and economic burdens of ASD on families and caregivers are profound. We recently showed in a small clinical trial that sulforaphane (SF) from broccoli sprouts could significantly reduce the behavioral symptoms of ASD...
2017: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/29147138/an-update-on-prucalopride-in-the-treatment-of-chronic-constipation
#20
REVIEW
Anam Omer, Eamonn M M Quigley
Chronic constipation (CC) is a highly prevalent and often under-appreciated gastrointestinal disorder associated with significant impairment in quality of life. Symptoms of constipation are typically present for a number of years prior to a patient seeking help. Lifestyle modifications followed by, or coupled with, over-the-counter laxatives represent the initial treatment option; however, relief for many is limited and dissatisfaction rates for these approaches remain high. Over recent years, therefore, considerable effort has been exerted on the development of novel pharmacological approaches...
November 2017: Therapeutic Advances in Gastroenterology
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