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Chlorpheniramine

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https://www.readbyqxmd.com/read/29445727/molecular-features-underlying-selectivity-in-chicken-bitter-taste-receptors
#1
Antonella Di Pizio, Nitzan Shy, Maik Behrens, Wolfgang Meyerhof, Masha Y Niv
Chickens sense the bitter taste of structurally different molecules with merely three bitter taste receptors ( Gallus gallus taste 2 receptors, ggTas2rs), representing a minimal case of bitter perception. Some bitter compounds like quinine, diphenidol and chlorpheniramine, activate all three ggTas2rs, while others selectively activate one or two of the receptors. We focus on bitter compounds with different selectivity profiles toward the three receptors, to shed light on the molecular recognition complexity in bitter taste...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29438504/potentially-inappropriate-medication-and-hospitalization-emergency-department-visits-among-the-elderly-in-korea
#2
Ha-Lim Jeon, Juhee Park, Euna Han, Dong-Sook Kim
Objective: To investigate the association between potentially inappropriate medicine (PIM) use, defined using the American Geriatric Society (AGS) 2012 Beers criteria, and the risk of hospitalization or emergency department (ED) visits in elderly patients, and to examine the most frequently used PIMs among patients with adverse outcomes. Design/Setting: This was a retrospective study using National Health Insurance claims data from 2010 to 2012. Intervention(s): Elderly patients who took PIMs are compared to those who were not taking PIMs...
February 1, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29386165/spectrophotometric-method-development-and-validation-for-determination-of-chlorpheniramine-maleate-in-bulk-and-controlled-release-tablets
#3
Maria Ashfaq, Ali Akber Sial, Rabia Bushra, Atta-Ur Rehman, Mirza Tasawur Baig, Ambreen Huma, Maryam Ahmed
Spectrophotometric technique is considered to be the simplest and operator friendly among other available analytical methods for pharmaceutical analysis. The objective of the study was to develop a precise, accurate and rapid UV-spectrophotometric method for the estimation of chlorpheniramine maleate (CPM) in pure and solid pharmaceutical formulation. Drug absorption was measured in various solvent systems including 0.1N HCl (pH 1.2), acetate buffer (pH 4.5), phosphate buffer (pH 6.8) and distil water (pH 7...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29298517/histamine-h1-receptor-antagonists-facilitate-electroacupuncture-analgesia
#4
Jaung-Geng Lin, Yu-Chen Lee, Cheng-Hao Tu, Iona MacDonald, Hsin-Yi Chung, Sih-Ting Luo, Shih-Ya Hung, Yi-Hung Chen
This study investigated the influence of the histamine H1 receptor antagonists, chlorpheniramine (CHL) and pyrilamine, on the analgesic effects of acupuncture in mice. Nociceptive response was evaluated by the acetic acid-induced abdominal writhe test. Electroacupuncture (EA) at bilateral ST36 reduced the manifestations of acetic acid-induced abdominal writhing, whereas needle insertion without electrostimulation had no such effect. Notably, EA treatment was not associated with any analgesic effects in mice pretreated with naloxone...
January 3, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29280084/the-effect-of-nesfatin-1-on-food-intake-in-neonatal-chicks-role-of-crf1-crf2-and-h1-h3-receptors
#5
Hooman Heidarzadeh, Morteza Zendehdel, Vahab Babapour, Hasan Gilanpour
The present study was designed to determine the effect of central injection of Nesfatin-1 and corticotropin and histaminergic systems on food intake in neonatal meat-type chicks. In this study, 7 experiments were designed, each with 4 treatment groups. In experiment 1, four groups of chicks received the ICV injection of (A) phosphate-buffered saline (PBS), (B) Nesfatin-1 (10 ng), (C) Nesfatin-1 (20 ng) and (D) Nesfatin-1 (40 ng). In experiment 2, (A) PBS, (B) Astressin-B (CRF1/CRF2 receptors antagonist; 30 µg), (C) Nesfatin-1 (40 ng) and (D) Nesfatin-1 + Astressin-B were injected...
December 26, 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/29227117/an-autopsy-case-of-death-by-combined-use-of-benzodiazepines-and-diphenidine
#6
Hiroshi Kinoshita, Naoko Tanaka, Ayaka Takakura, Hiroko Abe, Mitsuru Kumihashi, Takayuki Shibayama, Mostofa Jamal, Asuka Ito, Kunihiko Tsutsui, Shoji Kimura, Hirotaro Iwase, Kiyoshi Ameno
We present an autopsy case involving benzodiazepines and diphenidine. Quantitative toxicological analysis showed concentrations of 7-aminoflunitrazepam (a flunitrazepam metabolite), 7-aminonimetazepam (a nimetazepam metabolite), chlorpheniramine and diphenidine in femoral blood of 0.086 µg/ml, 0.027 µg/ml, 0.066 µg/ml, and 0.073 µg/ml, respectively. Death was attributed to combined toxicity due to the influence of multiple drug interactions.
2017: Soudní Lékarství
https://www.readbyqxmd.com/read/29197284/detection-of-ppcps-in-marine-organisms-from-contaminated-coastal-waters-of-the-saudi-red-sea
#7
Aasim M Ali, Helene Thorsen Rønning, Leiv K Sydnes, Walied M Alarif, Roland Kallenborn, Sultan S Al-Lihaibi
The occurrence of PPCPs in macroalgae, barnacle and fish samples from contaminated coastal waters of the Saudi Red Sea is reported. Solvent extraction followed by solid phase extraction was applied to isolate the compounds, and their quantification was carried out by high performance liquid chromatography-tandem mass spectrometry. Atenolol, ranitidine, chlorpheniramine, DEET, and atrazine were detected in one or more macroalgae at <LOQ concentration, whereas caffeine, methylparaben, and carbamazepine were present atmaximum concentrations of 41...
November 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29169285/relaxant-effect-of-curcuma-longa-on-rat-tracheal-smooth-muscle-and-its-possible-mechanisms
#8
Bahman Emami, Farzaneh Shakeri, Vahideh Ghorani, Mohammad Hossein Boskabady
CONTEXT: Turmeric is a spice obtained from the root of Curcuma longa L. (Zingiberaceae) with anti-aging, anticancer, anti-Alzheimer's disease, antioxidant and other medicinal properties. OBJECTIVE: The relaxant effect of C. longa on rat tracheal smooth muscle and its possible mechanisms were investigated in this study. MATERIALS AND METHODS: The relaxant effects of four cumulative concentrations of hydro-ethanol extract of C. longa (6.25, 12...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29169211/simultaneous-determination-of-kaempferol-quercetin-mangiferin-gallic-acid-p-hydroxybenzoic-acid-and-chlorpheniramine-maleate-in-rat-plasma-after-oral-administration-of-mang-guo-zhi-ke-tablets-by-uhplc-ms-ms-and-its-application-to-pharmacokinetics
#9
Weijie Xu, Jiagang Deng, Yiyun Qian, Xiao-Tao Hou, Zhenhua Zhu, Ming Zhao, Erxin Shang, Dawei Qian, Huiting Zeng, Hanqing Pang, Jinao Duan
Mang-Guo-Zhi-Ke Tablets (MGZKTS) is an effective Chinese patent medicine, contains mango leaf extract as the main raw material, and the antihistamine drug, chlorpheniramine maleate, is included in the formulation. However, its pharmacokinetic effect is rarely reported. A highly sensitive, reliable and rapid high-throughput method using ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) was used to simultaneously determine kaempferol, quercetin, mangiferin, p-hydroxybenzoic acid, gallic acid and chlorpheniramine maleate in rat plasma after oral administration of MGZKTS...
November 23, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29136286/brompheniramine-and-chlorpheniramine-pharmacokinetics-following-single-dose-oral-administration-in-children-aged-2-to-17-years
#10
Sudam Pathirana, Shyamalie Jayawardena, Suzanne Meeves, Gary A Thompson
Two pediatric studies characterized brompheniramine and chlorpheniramine pharmacokinetics in a total of 72 subjects, aged 2 to 17 years. A single age-/weight-based oral dose, ranging from 1 to 4 mg, was administered with 2 to 6 oz of water at least 2 hours after a light breakfast. Plasma samples were obtained before and for 72 hours after dosing and analyzed using high-pressure liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters were estimated using noncompartmental methods; relationships with age were assessed using linear regression...
November 14, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29114224/chlorpheniramine-potentiates-the-analgesic-effect-in-migraine-of-usual-caffeine-acetaminophen-and-acetylsalicylic-acid-combination
#11
Victor A Voicu, Ion Mircioiu, Roxana Sandulovici, Constantin Mircioiu, Cristina Plesa, Bruno S Velescu, Valentina Anuta
Previous studies indicated that addition of the antihistaminic chlorpheniramine to the usual combination of acetylsalicylic acid, acetaminophen, and caffeine further increases their synergism both in terms of anti-inflammatory and analgesic effect. The present non-interventional study tested the superiority of two Algopirin® tablets, containing a total of 250 mg acetylsalicylic acid (ASA), 150 mg acetaminophen (paracetamol, PAR), 30 mg caffeine (CAF) and 4 mg chlorpheniramine (CLF) vs. a combination containing 250 mg ASA, 250 mg PAR, and 65 mg CAF recognized as "safe and effective" by FDA in treating migraine...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29104484/chlorpheniramine-attenuates-histamine-mediated-aquaporin-5-downregulation-in-human-nasal-epithelial-cells-via-suppression-of-nf-%C3%AE%C2%BAb-activation
#12
Yung-Lung Chang, Chun-Shu Lin, Hsing-Won Wang, Kai Ren Jian, Shao-Cheng Liu
Background: Aquaporin 5 (AQP5) is most likely the primary water channel in the human nasal mucosa and acts as a key tight junction protein. The signaling cascades responsible for AQP5 regulation are still works in progress. Objective: This study sought to determine the effects of histamine and chlorpheniramine on AQP5 expression in human nasal epithelial cells (HNEpC) and to detect the signaling cascades responsible for these effects. Methods: HNEpC were cultured with four concentrations of histamine or chlorpheniramine in vitro...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29080492/stability-indicating-hplc-dad-method-for-analysis-of-ketorolac-binary-and-ternary-mixtures-in-eye-drops-quantitative-analysis-in-rabbit-aqueous-humor
#13
Fawzy A El Yazbi, Ekram M Hassan, Essam F Khamis, Marwa A A Ragab, Mohamed M A Hamdy
Ketorolac tromethamine (KTC) with phenylephrine hydrochloride (PHE) binary mixture (mixture 1) and their ternary mixture with chlorpheniramine maleate (CPM) (mixture 2) were analyzed using a validated HPLC-DAD method. The developed method was suitable for the in vitro as well as quantitative analysis of the targeted mixtures in rabbit aqueous humor. The analysis in dosage form (eye drops) was a stability indicating one at which drugs were separated from possible degradation products arising from different stress conditions (in vitro analysis)...
October 14, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29024852/the-cation-selective-exhaustive-injection-and-sweeping-capillary-electrophoresis-method-for-the-analysis-of-chlorpheniramine-enantiomers-in-rat-plasma
#14
Yaqi Yao, Li Zhou, Meng Li, Xingjie Guo
Chlorpheniramine is a potent antihistaminic administered as a racemic mixture, while its clinical activity is mainly associated with the S-enantiomer. In this study, a sensitive and rapid on-line preconcentration capillary electrophoresis (CE) method, cation-selective exhaustive injection (CSEI) and sweeping method was established and validated for the analysis of two chlorpheniramine enantiomers. Parameters influencing separation and enhancement efficiency were investigated, including cyclodextrin (CD) types and concentration, background electrolyte pH, type and content of organic modifier, injection time of water plug, injection time and voltage of sample...
September 18, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28825536/tlc-densitometric-and-rp-hplc-methods-for-simultaneous-determination-of-dexamethasone-and-chlorpheniramine-maleate-in-the-presence-of-methylparaben-and-propylparaben
#15
Nehal F Farid, Ibrahim A Naguib, Radwa S Moatamed, Mohamed R El Ghobashy
Validated simple, sensitive, and highly selective methods are applied for the quantitative determination of dexamethasone and chlorpheniramine maleate in the presence of their reported preservatives (methylparaben and propylparaben), whether in pure forms or in pharmaceutical formulation. TLC is the first method, in which dexamethasone, chlorpheniramine maleate, methylparaben, and propylparaben are separated on silica gel TLC F254 plates using hexane-acetone-ammonia (5.5 + 4.5 + 0.5, v/v/v) as the developing phase...
January 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28809091/different-localizations-of-drugs-simultaneously-administered-in-a-strand-of-hair-by-micro-segmental-analysis
#16
Kenji Kuwayama, Hajime Miyaguchi, Yuko T Iwata, Tatsuyuki Kanamori, Kenji Tsujikawa, Tadashi Yamamuro, Hiroki Segawa, Hiroyuki Inoue
Segmental hair analysis is used to estimate the time of drug intake at monthly precision in drug-related crimes. Previously we advanced this analytical method to specify the day of drug intake by cutting a strand of hair into 0.4-mm segments, which correspond to daily hair growth. Herein, we investigated the distributions of seven compounds in a strand of hair using micro-segmental analysis. Several strands of hair were collected 33.1-229.4 days after subjects were administered four pharmaceutical products that contained 10 drugs in single doses within 32 h...
August 15, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28769011/chlorpheniramine-increases-paracellular-permeability-to-marker-fluorescein-lucifer-yellow-mediated-by-internalization-of-occludin-in-murine-colonic-epithelial-cells
#17
Aya Manabe, Chisa Furukawa, Satoshi Endo, Kana Marunaka, Tsubasa Nishiyama, Naoko Fujii, Yoshiaki Tabuchi, Toshiyuki Matsunaga, Akira Ikari
Ions, small molecules, and drugs are absorbed in the intestinal epithelium mediated by transcellular and paracellular pathways. The function of various transporters expressing in the apical and basolateral membranes of intestinal epithelial cells has been well characterized. In contrast, claudins and occludin, components of the tight junctions (TJs), determine the paracellular permeability to ions and low molecular weight compounds, but the properties for permeability has not been clarified in detail. In the present study, we examined the effects of anti-histamine drugs, chlorpheniramine and diphenhydramine, on transepithelial electrical resistance (TER) and permeability to lucifer yellow (LY), a marker of paracellular permeability, using murine colonic MCE301 cells...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28764154/effect-of-agonist-and-antagonist-on-the-in-vitro-contractility-of-inflamed-vermiform-appendix
#18
Phani Bhushan Singh, Pushpakant Tiwary, Sanjeev K Singh, Ratna Pandey, Atanu Roy, Amrita Ghosh Kar, Somprakas Basu, Anil Kumar Tiwari
INTRODUCTION: Appendicitis poses a great health problem worldwide. Previous studies demonstrated structural damage to neuronal network and interstitial cell of Cajal in appendicitis. Above observations suggest for the alterations in appendicular motility/contractility in appendicitis. But the mechanisms involved in mediating the contractility in inflamed vermiform appendix is not known till date. AIM: The present in vitro study was performed to find out the mechanisms responsible for contractility in the inflamed human vermiform appendix...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28745076/effects-of-ici204-448-naloxone-methiodide-and-levocetirizine-on-the-scratching-behavior-induced-by-a-%C3%AE%C2%BA-opioid-antagonist-nor-bni-in-icr-mice
#19
Tasuku Nakasone, Hirokazu Wakuda, Yumi Sugimoto, Chiaki Kamei
OBJECTIVE: In this study, we aimed to study the effects of ICI204,448, naloxone methiodide and levocetirizine on the scratching behavior induced by intradermal injection of a ?-opioid antagonist, nor-binaltorphimine (nor-BNI), into the rostral back of ICR mice were investigated. MATERIALS AND METHODS: Male ICR mice weighing 30?35 g were used. The number of scratching episodes were counted for 60 min after i.d. injection of nor-BNI. RESULTS: nor-BNI dose dependently increased in the number of scratching episodes in ICR mice...
July 26, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28704328/randomized-controlled-trial-of-dexamethasone-versus-dexamethasone-plus-hydrocortisone-as-prophylaxis-for-hypersensitivity-reactions-due-to-paclitaxel-treatment-for-gynecologic-cancer
#20
Dhammapoj Jeerakornpassawat, Prapaporn Suprasert
OBJECTIVE: The aim of this study was to assess intravenous hydrocortisone (HCT) added to standard dexamethasone (DXM) prophylaxis for paclitaxel-associated hypersensitivity reactions (HSRs). METHODS: Paclitaxel naives scheduled for 6 cycles of paclitaxel (plus platinum) were randomized to DXM alone (20 mg intravenously [IV]) versus DXM plus HCT (100 mg IV) as premedication including chlorpheniramine (10 mg IV), diphenhydramine (25 mg orally), and ranitidine (50 mg IV) 30 minutes before infusion...
July 12, 2017: International Journal of Gynecological Cancer
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