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Chlorpheniramine

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https://www.readbyqxmd.com/read/29197284/detection-of-ppcps-in-marine-organisms-from-contaminated-coastal-waters-of-the-saudi-red-sea
#1
Aasim M Ali, Helene Thorsen Rønning, Leiv K Sydnes, Walied M Alarif, Roland Kallenborn, Sultan S Al-Lihaibi
The occurrence of PPCPs in macroalgae, barnacle and fish samples from contaminated coastal waters of the Saudi Red Sea is reported. Solvent extraction followed by solid phase extraction was applied to isolate the compounds, and their quantification was carried out by high performance liquid chromatography-tandem mass spectrometry. Atenolol, ranitidine, chlorpheniramine, DEET, and atrazine were detected in one or more macroalgae at <LOQ concentration, whereas caffeine, methylparaben, and carbamazepine were present atmaximum concentrations of 41...
November 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29169285/relaxant-effect-of-curcuma-longa-on-rat-tracheal-smooth-muscle-and-its-possible-mechanisms
#2
Bahman Emami, Farzaneh Shakeri, Vahideh Ghorani, Mohammad Hossein Boskabady
CONTEXT: Turmeric is a spice obtained from the root of Curcuma longa L. (Zingiberaceae) with anti-aging, anticancer, anti-Alzheimer's disease, antioxidant and other medicinal properties. OBJECTIVE: The relaxant effect of C. longa on rat tracheal smooth muscle and its possible mechanisms were investigated in this study. MATERIALS AND METHODS: The relaxant effects of four cumulative concentrations of hydro-ethanol extract of C. longa (6.25, 12...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29169211/simultaneous-determination-of-kaempferol-quercetin-mangiferin-gallic-acid-p-hydroxybenzoic-acid-and-chlorpheniramine-maleate-in-rat-plasma-after-oral-administration-of-mang-guo-zhi-ke-tablets-by-uhplc-ms-ms-and-its-application-to-pharmacokinetics
#3
Weijie Xu, Jiagang Deng, Yiyun Qian, Xiao-Tao Hou, Zhenhua Zhu, Ming Zhao, Erxin Shang, Dawei Qian, Huiting Zeng, Hanqing Pang, Jinao Duan
Mang-Guo-Zhi-Ke Tablets (MGZKTS) is an effective Chinese patent medicine, contains mango leaf extract as the main raw material, and the antihistamine drug, chlorpheniramine maleate, is included in the formulation. However, its pharmacokinetic effect is rarely reported. A highly sensitive, reliable and rapid high-throughput method using ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) was used to simultaneously determine kaempferol, quercetin, mangiferin, p-hydroxybenzoic acid, gallic acid and chlorpheniramine maleate in rat plasma after oral administration of MGZKTS...
November 23, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29136286/brompheniramine-and-chlorpheniramine-pharmacokinetics-following-single-dose-oral-administration-in-children-aged-2-to-17-years
#4
Sudam Pathirana, Shyamalie Jayawardena, Suzanne Meeves, Gary A Thompson
Two pediatric studies characterized brompheniramine and chlorpheniramine pharmacokinetics in a total of 72 subjects, aged 2 to 17 years. A single age-/weight-based oral dose, ranging from 1 to 4 mg, was administered with 2 to 6 oz of water at least 2 hours after a light breakfast. Plasma samples were obtained before and for 72 hours after dosing and analyzed using high-pressure liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters were estimated using noncompartmental methods; relationships with age were assessed using linear regression...
November 14, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29114224/chlorpheniramine-potentiates-the-analgesic-effect-in-migraine-of-usual-caffeine-acetaminophen-and-acetylsalicylic-acid-combination
#5
Victor A Voicu, Ion Mircioiu, Roxana Sandulovici, Constantin Mircioiu, Cristina Plesa, Bruno S Velescu, Valentina Anuta
Previous studies indicated that addition of the antihistaminic chlorpheniramine to the usual combination of acetylsalicylic acid, acetaminophen, and caffeine further increases their synergism both in terms of anti-inflammatory and analgesic effect. The present non-interventional study tested the superiority of two Algopirin® tablets, containing a total of 250 mg acetylsalicylic acid (ASA), 150 mg acetaminophen (paracetamol, PAR), 30 mg caffeine (CAF) and 4 mg chlorpheniramine (CLF) vs. a combination containing 250 mg ASA, 250 mg PAR, and 65 mg CAF recognized as "safe and effective" by FDA in treating migraine...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29104484/chlorpheniramine-attenuates-histamine-mediated-aquaporin-5-downregulation-in-human-nasal-epithelial-cells-via-suppression-of-nf-%C3%AE%C2%BAb-activation
#6
Yung-Lung Chang, Chun-Shu Lin, Hsing-Won Wang, Kai Ren Jian, Shao-Cheng Liu
Background: Aquaporin 5 (AQP5) is most likely the primary water channel in the human nasal mucosa and acts as a key tight junction protein. The signaling cascades responsible for AQP5 regulation are still works in progress. Objective: This study sought to determine the effects of histamine and chlorpheniramine on AQP5 expression in human nasal epithelial cells (HNEpC) and to detect the signaling cascades responsible for these effects. Methods: HNEpC were cultured with four concentrations of histamine or chlorpheniramine in vitro...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29080492/stability-indicating-hplc-dad-method-for-analysis-of-ketorolac-binary-and-ternary-mixtures-in-eye-drops-quantitative-analysis-in-rabbit-aqueous-humor
#7
Fawzy A El Yazbi, Ekram M Hassan, Essam F Khamis, Marwa A A Ragab, Mohamed M A Hamdy
Ketorolac tromethamine (KTC) with phenylephrine hydrochloride (PHE) binary mixture (mixture 1) and their ternary mixture with chlorpheniramine maleate (CPM) (mixture 2) were analyzed using a validated HPLC-DAD method. The developed method was suitable for the in vitro as well as quantitative analysis of the targeted mixtures in rabbit aqueous humor. The analysis in dosage form (eye drops) was a stability indicating one at which drugs were separated from possible degradation products arising from different stress conditions (in vitro analysis)...
October 14, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29024852/the-cation-selective-exhaustive-injection-and-sweeping-capillary-electrophoresis-method-for-the-analysis-of-chlorpheniramine-enantiomers-in-rat-plasma
#8
Yaqi Yao, Li Zhou, Meng Li, Xingjie Guo
Chlorpheniramine is a potent antihistaminic administered as a racemic mixture, while its clinical activity is mainly associated with the S-enantiomer. In this study, a sensitive and rapid on-line preconcentration capillary electrophoresis (CE) method, cation-selective exhaustive injection (CSEI) and sweeping method was established and validated for the analysis of two chlorpheniramine enantiomers. Parameters influencing separation and enhancement efficiency were investigated, including cyclodextrin (CD) types and concentration, background electrolyte pH, type and content of organic modifier, injection time of water plug, injection time and voltage of sample...
September 18, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28825536/tlc-densitometric-and-rp-hplc-methods-for-simultaneous-determination-of-dexamethasone-and-chlorpheniramine-maleate-in-the-presence-of-methylparaben-and-propylparaben
#9
Nehal F Farid, Ibrahim A Naguib, Radwa S Moatamed, Mohamed R El Ghobashy
Validated simple, sensitive, and highly selective methods are applied for the quantitative determination of dexamethasone and chlorpheniramine maleate in the presence of their reported preservatives (methylparaben and propylparaben), whether in pure forms or in pharmaceutical formulation. TLC is the first method, in which dexamethasone, chlorpheniramine maleate, methylparaben, and propylparaben are separated on silica gel TLC F254 plates using hexane-acetone-ammonia (5.5 + 4.5 + 0.5, v/v/v) as the developing phase...
January 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28809091/different-localizations-of-drugs-simultaneously-administered-in-a-strand-of-hair-by-micro-segmental-analysis
#10
Kenji Kuwayama, Hajime Miyaguchi, Yuko T Iwata, Tatsuyuki Kanamori, Kenji Tsujikawa, Tadashi Yamamuro, Hiroki Segawa, Hiroyuki Inoue
Segmental hair analysis is used to estimate the time of drug intake at monthly precision in drug-related crimes. Previously we advanced this analytical method to specify the day of drug intake by cutting a strand of hair into 0.4-mm segments, which correspond to daily hair growth. Herein, we investigated the distributions of seven compounds in a strand of hair using micro-segmental analysis. Several strands of hair were collected 33.1-229.4 days after subjects were administered four pharmaceutical products that contained 10 drugs in single doses within 32 h...
August 15, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28769011/chlorpheniramine-increases-paracellular-permeability-to-marker-fluorescein-lucifer-yellow-mediated-by-internalization-of-occludin-in-murine-colonic-epithelial-cells
#11
Aya Manabe, Chisa Furukawa, Satoshi Endo, Kana Marunaka, Tsubasa Nishiyama, Naoko Fujii, Yoshiaki Tabuchi, Toshiyuki Matsunaga, Akira Ikari
Ions, small molecules, and drugs are absorbed in the intestinal epithelium mediated by transcellular and paracellular pathways. The function of various transporters expressing in the apical and basolateral membranes of intestinal epithelial cells has been well characterized. In contrast, claudins and occludin, components of the tight junctions (TJs), determine the paracellular permeability to ions and low molecular weight compounds, but the properties for permeability has not been clarified in detail. In the present study, we examined the effects of anti-histamine drugs, chlorpheniramine and diphenhydramine, on transepithelial electrical resistance (TER) and permeability to lucifer yellow (LY), a marker of paracellular permeability, using murine colonic MCE301 cells...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28764154/effect-of-agonist-and-antagonist-on-the-in-vitro-contractility-of-inflamed-vermiform-appendix
#12
Phani Bhushan Singh, Pushpakant Tiwary, Sanjeev K Singh, Ratna Pandey, Atanu Roy, Amrita Ghosh Kar, Somprakas Basu, Anil Kumar Tiwari
INTRODUCTION: Appendicitis poses a great health problem worldwide. Previous studies demonstrated structural damage to neuronal network and interstitial cell of Cajal in appendicitis. Above observations suggest for the alterations in appendicular motility/contractility in appendicitis. But the mechanisms involved in mediating the contractility in inflamed vermiform appendix is not known till date. AIM: The present in vitro study was performed to find out the mechanisms responsible for contractility in the inflamed human vermiform appendix...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28745076/effects-of-ici204-448-naloxone-methiodide-and-levocetirizine-on-the-scratching-behavior-induced-by-a-%C3%AE%C2%BA-opioid-antagonist-nor-bni-in-icr-mice
#13
Tasuku Nakasone, Hirokazu Wakuda, Yumi Sugimoto, Chiaki Kamei
OBJECTIVE: In this study, we aimed to study the effects of ICI204,448, naloxone methiodide and levocetirizine on the scratching behavior induced by intradermal injection of a ?-opioid antagonist, nor-binaltorphimine (nor-BNI), into the rostral back of ICR mice were investigated. MATERIALS AND METHODS: Male ICR mice weighing 30?35 g were used. The number of scratching episodes were counted for 60 min after i.d. injection of nor-BNI. RESULTS: nor-BNI dose dependently increased in the number of scratching episodes in ICR mice...
July 26, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28704328/randomized-controlled-trial-of-dexamethasone-versus-dexamethasone-plus-hydrocortisone-as-prophylaxis-for-hypersensitivity-reactions-due-to-paclitaxel-treatment-for-gynecologic-cancer
#14
Dhammapoj Jeerakornpassawat, Prapaporn Suprasert
OBJECTIVE: The aim of this study was to assess intravenous hydrocortisone (HCT) added to standard dexamethasone (DXM) prophylaxis for paclitaxel-associated hypersensitivity reactions (HSRs). METHODS: Paclitaxel naives scheduled for 6 cycles of paclitaxel (plus platinum) were randomized to DXM alone (20 mg intravenously [IV]) versus DXM plus HCT (100 mg IV) as premedication including chlorpheniramine (10 mg IV), diphenhydramine (25 mg orally), and ranitidine (50 mg IV) 30 minutes before infusion...
July 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28596037/development-and-evaluation-of-an-oral-fast-disintegrating-anti-allergic-film-using-hot-melt-extrusion-technology
#15
Manjeet B Pimparade, Anh Vo, Abhijeet S Maurya, Jungeun Bae, Joseph T Morott, Xin Feng, Dong Wuk Kim, Vijay I Kulkarni, Roshan Tiwari, K Vanaja, Reena Murthy, H N Shivakumar, D Neupane, S R Mishra, S N Murthy, Michael A Repka
The main objective of this novel study was to develop chlorpheniramine maleate orally disintegrating films (ODF) using hot-melt extrusion technology and evaluate the characteristics of the formulation using in vitro and in vivo methods. Modified starch with glycerol was used as a polymer matrix for melt extrusion. Sweetening and saliva-simulating agents were incorporated to improve palatability and lower the disintegration time of film formulations. A standard screw configuration was applied, and the last zone of the barrel was opened to discharge water vapors, which helped to manufacture non-sticky, clear, and uniform films...
October 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28584640/chlorpheniramine-and-escitalopram-similar-antidepressant-and-nitric-oxide-lowering-roles-in-a-mouse-model-of-anxiety
#16
Omar Gammoh, Fadia Mayyas, Feras Darwish Elhajji
There is a crosstalk between mood disorders and oxidative stress. Chlorpheniramine (CPA), a first generation antihistamine, is hypothesized to have an anxiolytic role at high doses; however, its antidepressant and antioxidant roles have not previously been investigated. The aim of the current study was to evaluate the antidepressant and anxiolytic effects of CPA treatment in association with nitric oxide (NO) and super oxide dismutase (SOD) activity in a mouse model of anxiety. BALB/c mice were divided into unstressed (naïve), control, and CPA- (0...
June 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28562262/safety-profile-of-cough-and-cold-medication-use-in-pediatrics
#17
Jody L Green, George Sam Wang, Kate M Reynolds, William Banner, G Randall Bond, Ralph E Kauffman, Robert B Palmer, Ian M Paul, Richard C Dart
BACKGROUND AND OBJECTIVES: The safety of cough and cold medication (CCM) use in children has been questioned. We describe the safety profile of CCMs in children <12 years of age from a multisystem surveillance program. METHODS: Cases with adverse events (AEs) after ingestion of at least 1 index CCM ingredient (brompheniramine, chlorpheniramine, dextromethorphan, diphenhydramine, doxylamine, guaifenesin, phenylephrine, and pseudoephedrine) in children <12 years of age were collected from 5 data sources...
June 2017: Pediatrics
https://www.readbyqxmd.com/read/28482472/caffeine-a-novel-green-precursor-for-synthesis-of-magnetic-cofe2o4-nanoparticles-and-ph-sensitive-magnetic-alginate-beads-for-drug-delivery
#18
Mahnaz Amiri, Masoud Salavati-Niasari, Abbas Pardakhty, Meysam Ahmadi, Ahmad Akbari
Hydrogel beads are promising delivery systems for encapsulation and release of drugs due to the mild process of their fabrication from biopolymers. Magnetic CoFe2O4 nanoparticles (MCFO, 9.72nm in diameter) were synthesized via a co-precipitation method using caffeine as a new environmentally friendly material in order to alkalinize the medium. Drug-targeting Magnetic beads based on CoFe2O4 nanoparticles, sodium alginate and chlorpheniramine maleate (CPAM) were synthesized in the presence of Ca(2+) ions to obtain ionic cross-linked magnetic hydrogel beads...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28469883/allergic-contact-dermatitis-following-drug-rash-due-to-chlorpheniramine-maleate
#19
Kiyoshi Shikino, Takako Masuyama, Tomoko Yamashita, Masatomi Ikusaka
Allergic contact dermatitis (ACD) is one of the common causes of facial swelling. Clinical clues for diagnosing ACD include a rash that spares the area behind the ears, nasolabial folds, and under the chin. Once clinicians suspect ACD, the substances that cause contact dermatitis should be avoided.
May 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28292010/the-anti-allergic-and-anti-inflammatory-effects-of-benjakul-extract-a-thai-traditional-medicine-its-constituent-plants-and-its-some-pure-constituents-using-in-vitro-experiments
#20
Sunita Makchuchit, Ruchilak Rattarom, Arunporn Itharat
Benjakul (BJK), a Thai traditional medicine preparation, has long been used for balanced health, controlled abnormal of element in the body, carminative, and relief of flatulence. It is composed of five plants: Piper interruptum Opiz., Piper longum L., Piper sarmentosum Roxb., Plumbago indica L., and Zingiber officinale Roscoe. The ethanolic extracts of BJK, its five individual plants, and pure constituents of BJK were investigated for their anti-allergic activity using immunoglobulin E (IgE)-sensitized β-hexosaminidase in the rat basophilic leukemia-2H3 (RBL-2H3) cells and anti-inflammatory activity using lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α) in the murine macrophage (RAW 264...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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