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https://www.readbyqxmd.com/read/29657733/contrast-medium-induced-transient-severe-leukopenia
#1
Takashi Hongo, Satoshi Nozaki, Midori Tsuchiya, Mototaka Inaba, Kenji Takahashi, Toshifumi Fujiwara
Case: Contrast medium-induced transient leukopenia is very rare. Here, we report a case of a 73-year-old man diagnosed with contrast media-induced transient leukopenia. The patient underwent abdominal contrast-enhanced computed tomography, where he was given non-ionic iodinated contrast medium i.v. His medical history included an allergic reaction to a different contrast medium. One hour later, the patient was admitted to the emergency department complaining of chest discomfort. He had leukopenia and a fever (temperature of 38...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29644705/a-fully-validated-method-for-the-simultaneous-determination-of-11-antihistamines-in-breast-milk-by-gas-chromatography-mass-spectrometry
#2
Maria Katselou, Sotiris Athanaselis, Panagiota Nikolaou, Samir Qammaz, Artemisia Dona, Chara Spiliopoulou, Ioannis Papoutsis
Antihistamines are excreted into breast milk in small amounts; however, there are no adequate published studies or data concerning their effects on newborns and safety during breastfeeding. Thus, the development of sensitive and specific methodologies for the determination of antihistamines in breast milk is critical. A simple and sensitive GC-MS method for the simultaneous determination of eleven antihistamines (diphenhydramine, orphenadrine, chlorpheniramine, dimethindene, meclozine, hydroxyzine, loratadine, desloratadine, cetirizine, rupatadine and ebastine) in breast milk was developed and validated...
April 12, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29615980/histamine-regulates-molecular-clock-oscillations-in-human-retinal-pigment-epithelial-cells-via-h-1-receptors
#3
Eri Morioka, Yuzuki Kanda, Hayato Koizumi, Tsubasa Miyamoto, Masayuki Ikeda
Vertebrate eyes are known to contain circadian clocks, but their regulatory mechanisms remain largely unknown. To address this, we used a cell line from human retinal pigment epithelium (hRPE-YC) with stable coexpression of reporters for molecular clock oscillations ( Bmal1-luciferase ) and intracellular Ca2+ concentrations ( YC3.6 ). We observed concentration-dependent increases in cytosolic Ca2+ concentrations after treatment with histamine (1-100 µM) and complete suppression of histamine-induced Ca2+ mobilizations by H1 histamine receptor (H1 R) antagonist d -chlorpheniramine ( d -CPA) in hRPE-YC cells...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29563423/paediatric-over-the-counter-otc-oral-liquids-can-soften-and-erode-enamel
#4
Dan Zhao, James Kit-Hon Tsoi, Hai Ming Wong, Chun Hung Chu, Jukka P Matinlinna
This study investigated the softening and erosive effects of various paediatric over-the-counter (OTC) oral liquids on deciduous teeth. Twenty sectioned and polished deciduous enamel blocks were ground on the buccal surface (2 × 2 mm²) and randomly divided into five groups, immersed into four commercially-available paediatric OTC oral liquids (two for paracetamol, both sugared; and two for chlorpheniramine, one sugared and one sugar-free), with deionized water as control. The pH of the oral liquids ranged from 2...
May 11, 2017: Dentistry journal
https://www.readbyqxmd.com/read/29553437/drug-dosing-errors-in-outpatient-paediatric-patients-at-primary-health-care-centres-in-nablus-a-cross-sectional-study
#5
Rowa' Al-Ramahi, Hamzeh Al-Zabadi, Ghadeer Al-Shareef
BACKGROUND: Paediatric patients are highly sensitive to drug-related problems such as dosing errors. Some dosing errors are preventable with suitable strategies. The aim of this study was to assess the prevalence of drug dosing errors in outpatient paediatric patients who attended primary health-care centres in Nablus and to identify possible associated factors. METHODS: For this cross-sectional study, we reviewed doctors' prescriptions for paediatric patients aged between 1 day and 12 years...
February 21, 2018: Lancet
https://www.readbyqxmd.com/read/29543860/south-korean-geriatrics-on-beers-criteria-medications-at-risk-of-adverse-drug-events
#6
Grace Juyun Kim, Kye Hwa Lee, Ju Han Kim
BACKGROUND: The Beers Criteria released by the American Geriatrics Society includes a list of drugs to avoid in the geriatric population and is frequently used as a safety resource in geriatric pharmacotherapy. OBJECTIVE: To evaluate the exposure of South Korean geriatrics to potentially inappropriate medications according to the Beers Criteria and the risk of adverse events from these medications. METHODS: This study included medications recommended to be avoided in patients 65 years or older regardless of concomitant drug therapy or disease...
2018: PloS One
https://www.readbyqxmd.com/read/29486155/persistent-erk-activation-by-the-histamine-h4-receptor-in-spinal-neurons-underlies-chronic-itch
#7
Kun Huang, Dan-Dan Hu, Dong Bai, Ze-Yang Wu, Yi-Yang Chen, Yi-Jun Zhang, Xin Lv, Qing-Xiu Wang, Ling Zhang
Transient extracellular signal-regulated kinase (ERK) activation in the spinal cord triggers histamine-induced acute itch. However, whether persistent ERK activation plays an important role in chronic itch development remains unclear. This study investigated the role of spinal ERK activation in chronic itch. The results showed that repetitive 2,4-dinitrofluorobenzene (DNFB) painting on the nape of mice evoked not only initial scratching but also sustained, spontaneous scratching. In addition, DNFB induced itching rather than nociception, as demonstrated using a cheek model...
February 24, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29445727/molecular-features-underlying-selectivity-in-chicken-bitter-taste-receptors
#8
Antonella Di Pizio, Nitzan Shy, Maik Behrens, Wolfgang Meyerhof, Masha Y Niv
Chickens sense the bitter taste of structurally different molecules with merely three bitter taste receptors ( Gallus gallus taste 2 receptors, ggTas2rs), representing a minimal case of bitter perception. Some bitter compounds like quinine, diphenidol and chlorpheniramine, activate all three ggTas2rs, while others selectively activate one or two of the receptors. We focus on bitter compounds with different selectivity profiles toward the three receptors, to shed light on the molecular recognition complexity in bitter taste...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29438504/potentially-inappropriate-medication-and-hospitalization-emergency-department-visits-among-the-elderly-in-korea
#9
Ha-Lim Jeon, Juhee Park, Euna Han, Dong-Sook Kim
Objective: To investigate the association between potentially inappropriate medicine (PIM) use, defined using the American Geriatric Society (AGS) 2012 Beers criteria, and the risk of hospitalization or emergency department (ED) visits in elderly patients, and to examine the most frequently used PIMs among patients with adverse outcomes. Design/Setting: This was a retrospective study using National Health Insurance claims data from 2010 to 2012. Intervention(s): Elderly patients who took PIMs are compared to those who were not taking PIMs...
February 1, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29386165/spectrophotometric-method-development-and-validation-for-determination-of-chlorpheniramine-maleate-in-bulk-and-controlled-release-tablets
#10
Maria Ashfaq, Ali Akber Sial, Rabia Bushra, Atta-Ur Rehman, Mirza Tasawur Baig, Ambreen Huma, Maryam Ahmed
Spectrophotometric technique is considered to be the simplest and operator friendly among other available analytical methods for pharmaceutical analysis. The objective of the study was to develop a precise, accurate and rapid UV-spectrophotometric method for the estimation of chlorpheniramine maleate (CPM) in pure and solid pharmaceutical formulation. Drug absorption was measured in various solvent systems including 0.1N HCl (pH 1.2), acetate buffer (pH 4.5), phosphate buffer (pH 6.8) and distil water (pH 7...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29298517/histamine-h-1-receptor-antagonists-facilitate-electroacupuncture-analgesia
#11
Jaung-Geng Lin, Yu-Chen Lee, Cheng-Hao Tu, Iona MacDonald, Hsin-Yi Chung, Sih-Ting Luo, Shih-Ya Hung, Yi-Hung Chen
This study investigated the influence of the histamine H1 receptor antagonists, chlorpheniramine (CHL) and pyrilamine, on the analgesic effects of acupuncture in mice. Nociceptive response was evaluated by the acetic acid-induced abdominal writhe test. Electroacupuncture (EA) at bilateral ST36 reduced the manifestations of acetic acid-induced abdominal writhing, whereas needle insertion without electrostimulation had no such effect. Notably, EA treatment was not associated with any analgesic effects in mice pretreated with naloxone...
2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29280084/the-effect-of-nesfatin-1-on-food-intake-in-neonatal-chicks-role-of-crf-1-crf2-and-h1-h3-receptors
#12
Hooman Heidarzadeh, Morteza Zendehdel, Vahab Babapour, Hasan Gilanpour
The present study was designed to determine the effect of central injection of Nesfatin-1 and corticotropin and histaminergic systems on food intake in neonatal meat-type chicks. In this study, 7 experiments were designed, each with 4 treatment groups. In experiment 1, four groups of chicks received the ICV injection of (A) phosphate-buffered saline (PBS), (B) Nesfatin-1 (10 ng), (C) Nesfatin-1 (20 ng) and (D) Nesfatin-1 (40 ng). In experiment 2, (A) PBS, (B) Astressin-B (CRF1 /CRF2 receptors antagonist; 30 µg), (C) Nesfatin-1 (40 ng) and (D) Nesfatin-1 + Astressin-B were injected...
March 2018: Veterinary Research Communications
https://www.readbyqxmd.com/read/29227117/an-autopsy-case-of-death-by-combined-use-of-benzodiazepines-and-diphenidine
#13
Hiroshi Kinoshita, Naoko Tanaka, Ayaka Takakura, Hiroko Abe, Mitsuru Kumihashi, Takayuki Shibayama, Mostofa Jamal, Asuka Ito, Kunihiko Tsutsui, Shoji Kimura, Hirotaro Iwase, Kiyoshi Ameno
We present an autopsy case involving benzodiazepines and diphenidine. Quantitative toxicological analysis showed concentrations of 7-aminoflunitrazepam (a flunitrazepam metabolite), 7-aminonimetazepam (a nimetazepam metabolite), chlorpheniramine and diphenidine in femoral blood of 0.086 µg/ml, 0.027 µg/ml, 0.066 µg/ml, and 0.073 µg/ml, respectively. Death was attributed to combined toxicity due to the influence of multiple drug interactions.
2017: Soudní Lékarství
https://www.readbyqxmd.com/read/29197284/detection-of-ppcps-in-marine-organisms-from-contaminated-coastal-waters-of-the-saudi-red-sea
#14
Aasim M Ali, Helene Thorsen Rønning, Leiv K Sydnes, Walied M Alarif, Roland Kallenborn, Sultan S Al-Lihaibi
The occurrence of PPCPs in macroalgae, barnacle and fish samples from contaminated coastal waters of the Saudi Red Sea is reported. Solvent extraction followed by solid phase extraction was applied to isolate the compounds, and their quantification was carried out by high performance liquid chromatography-tandem mass spectrometry. Atenolol, ranitidine, chlorpheniramine, DEET, and atrazine were detected in one or more macroalgae at <LOQ concentration, whereas caffeine, methylparaben, and carbamazepine were present atmaximum concentrations of 41...
April 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29169285/relaxant-effect-of-curcuma-longa-on-rat-tracheal-smooth-muscle-and-its-possible-mechanisms
#15
Bahman Emami, Farzaneh Shakeri, Vahideh Ghorani, Mohammad Hossein Boskabady
CONTEXT: Turmeric is a spice obtained from the root of Curcuma longa L. (Zingiberaceae) with anti-aging, anticancer, anti-Alzheimer's disease, antioxidant and other medicinal properties. OBJECTIVE: The relaxant effect of C. longa on rat tracheal smooth muscle and its possible mechanisms were investigated in this study. MATERIALS AND METHODS: The relaxant effects of four cumulative concentrations of hydro-ethanol extract of C. longa (6.25, 12...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29169211/simultaneous-determination-of-kaempferol-quercetin-mangiferin-gallic-acid-p-hydroxybenzoic-acid-and-chlorpheniramine-maleate-in-rat-plasma-after-oral-administration-of-mang-guo-zhi-ke-tablets-by-uhplc-ms-ms-and-its-application-to-pharmacokinetics
#16
Weijie Xu, Jiagang Deng, Yiyun Qian, Xiao-Tao Hou, Zhenhua Zhu, Ming Zhao, Erxin Shang, Dawei Qian, Huiting Zeng, Hanqing Pang, Jinao Duan
Mang-Guo-Zhi-Ke Tablets (MGZKTS) is an effective Chinese patent medicine, contains mango leaf extract as the main raw material, and the antihistamine drug, chlorpheniramine maleate, is included in the formulation. However, its pharmacokinetic effect is rarely reported. A highly sensitive, reliable and rapid high-throughput method using ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) was used to simultaneously determine kaempferol, quercetin, mangiferin, p-hydroxybenzoic acid, gallic acid and chlorpheniramine maleate in rat plasma after oral administration of MGZKTS...
November 23, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29136286/brompheniramine-and-chlorpheniramine-pharmacokinetics-following-single-dose-oral-administration-in-children-aged-2-to-17-years
#17
Sudam Pathirana, Shyamalie Jayawardena, Suzanne Meeves, Gary A Thompson
Two pediatric studies characterized brompheniramine and chlorpheniramine pharmacokinetics in a total of 72 subjects, aged 2 to 17 years. A single age-/weight-based oral dose, ranging from 1 to 4 mg, was administered with 2 to 6 oz of water at least 2 hours after a light breakfast. Plasma samples were obtained before and for 72 hours after dosing and analyzed using high-pressure liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters were estimated using noncompartmental methods; relationships with age were assessed using linear regression...
November 14, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29114224/chlorpheniramine-potentiates-the-analgesic-effect-in-migraine-of-usual-caffeine-acetaminophen-and-acetylsalicylic-acid-combination
#18
Victor A Voicu, Ion Mircioiu, Roxana Sandulovici, Constantin Mircioiu, Cristina Plesa, Bruno S Velescu, Valentina Anuta
Previous studies indicated that addition of the antihistaminic chlorpheniramine to the usual combination of acetylsalicylic acid, acetaminophen, and caffeine further increases their synergism both in terms of anti-inflammatory and analgesic effect. The present non-interventional study tested the superiority of two Algopirin® tablets, containing a total of 250 mg acetylsalicylic acid (ASA), 150 mg acetaminophen (paracetamol, PAR), 30 mg caffeine (CAF) and 4 mg chlorpheniramine (CLF) vs. a combination containing 250 mg ASA, 250 mg PAR, and 65 mg CAF recognized as "safe and effective" by FDA in treating migraine...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29104484/chlorpheniramine-attenuates-histamine-mediated-aquaporin-5-downregulation-in-human-nasal-epithelial-cells-via-suppression-of-nf-%C3%AE%C2%BAb-activation
#19
Yung-Lung Chang, Chun-Shu Lin, Hsing-Won Wang, Kai Ren Jian, Shao-Cheng Liu
Background: Aquaporin 5 (AQP5) is most likely the primary water channel in the human nasal mucosa and acts as a key tight junction protein. The signaling cascades responsible for AQP5 regulation are still works in progress. Objective: This study sought to determine the effects of histamine and chlorpheniramine on AQP5 expression in human nasal epithelial cells (HNEpC) and to detect the signaling cascades responsible for these effects. Methods: HNEpC were cultured with four concentrations of histamine or chlorpheniramine in vitro...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29080492/stability-indicating-hplc-dad-method-for-analysis-of-ketorolac-binary-and-ternary-mixtures-in-eye-drops-quantitative-analysis-in-rabbit-aqueous-humor
#20
Fawzy A El Yazbi, Ekram M Hassan, Essam F Khamis, Marwa A A Ragab, Mohamed M A Hamdy
Ketorolac tromethamine (KTC) with phenylephrine hydrochloride (PHE) binary mixture (mixture 1) and their ternary mixture with chlorpheniramine maleate (CPM) (mixture 2) were analyzed using a validated HPLC-DAD method. The developed method was suitable for the in vitro as well as quantitative analysis of the targeted mixtures in rabbit aqueous humor. The analysis in dosage form (eye drops) was a stability indicating one at which drugs were separated from possible degradation products arising from different stress conditions (in vitro analysis)...
November 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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