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https://www.readbyqxmd.com/read/29858070/linc-ror-promotes-osteogenic-differentiation-of-mesenchymal-stem-cells-by-functioning-as-a-competing-endogenous-rna-for-mir-138-and-mir-145
#1
Lu Feng, Liu Shi, Ying-Fei Lu, Bin Wang, Tao Tang, Wei-Ming Fu, Wei He, Gang Li, Jin-Fang Zhang
Long noncoding RNAs (lncRNAs), which serve as important and powerful regulators of various biological activities, have gained widespread attention in recent years. Emerging evidence has shown that some lncRNAs play important regulatory roles in osteoblast differentiation of mesenchymal stem cells (MSCs), suggesting a potential therapeutic strategy for bone fracture. As a recently identified lncRNA, linc-ROR was reported to mediate the reprogramming ability of differentiated cells into induced pluripotent stem cells (iPSCs) and human embryonic stem cells (ESCs) self-renewal...
June 1, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29843710/gene-expression-of-the-liver-of-vaccination-protected-mice-in-response-to-early-patent-infections-of-plasmodium-chabaudi-blood-stage-malaria
#2
Saleh Al-Quraishy, Mohamed A Dkhil, E M Al-Shaebi, Abdel-Azeem S Abdel-Baki, Marcos J Araúzo-Bravo, Denis Delic, Frank Wunderlich
BACKGROUND: The role of the liver for survival of blood-stage malaria is only poorly understood. In experimental blood-stage malaria with Plasmodium chabaudi, protective vaccination induces healing and, thus, survival of otherwise lethal infections. This model is appropriate to study the role of the liver in vaccination-induced survival of blood-stage malaria. METHODS: Female Balb/c mice were vaccinated with a non-infectious vaccine consisting of plasma membranes isolated in the form of erythrocyte ghosts from P...
May 29, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29790665/long-noncoding-rna-ufc1-is-activated-by-e2f1-and-exerts-oncogenic-properties-by-functioning-as-a-cerna-of-foxp3
#3
Jie Xi, Jing Feng, Saitian Zeng, Ping Huang
Cervical cancer is one of the most common gynecologic cancers around the world. Long noncoding RNAs (lncRNAs) are considered to be important regulators of some biological processes. Recently, it has been reported that linc-UFC1 is a putative oncogene in some cancers. However, the functional roles of linc-UFC1 have not been investigated in cervical cancer. Here, it was demonstrated that linc-UFC1 expression was significantly increased in cervical cancer tissues, and its overexpression was associated with the poor survival of patients with cervical cancer...
May 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29755127/a-novel-long-non-coding-rna-linc-znf469-3-promotes-lung-metastasis-through-mir-574-5p-zeb1-axis-in-triple-negative-breast-cancer
#4
Po-Shun Wang, Cheng-Han Chou, Cheng-Han Lin, Yun-Chin Yao, Hui-Chuan Cheng, Hao-Yi Li, Yu-Chung Chuang, Chia-Ning Yang, Luo-Ping Ger, Yu-Chia Chen, Forn-Chia Lin, Tang-Long Shen, Michael Hsiao, Pei-Jung Lu
Triple-negative breast cancer (TNBC) patients usually lead to poor prognosis and survival because of metastasis. The major sites for TNBC metastasis include the lungs, brain, liver, and bone. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts longer than 200 nucleotides and have been reported as important regulators in BC metastasis. However, the underlying mechanisms for lncRNAs regulating TNBC metastasis are not fully understood. Here we found that linc-ZNF469-3 was highly expressed in lung-metastatic LM2-4175 TNBC cells and overexpression of linc-ZNF469-3 enhanced invasion ability and stemness properties in vitro and lung metastasis in vivo...
May 14, 2018: Oncogene
https://www.readbyqxmd.com/read/29742191/gene-expression-analysis-differentiates-melanomas-from-spitz-nevi
#5
Burkhard Jansen, Doyle Hansen, Ronald Moy, Maesa Hanhan, Zuxu Yao
INTRODUCTION: Pediatric Spitz nevi can pose significant diagnostic challenges to both clinicians and dermatopathologists when the current image-recognition based gold standard is employed. PRAME (preferentially expressed antigen in melanoma) and/or LINC (long intergeneic non-coding RNA 518) gene expression in adult patients in samples obtained non-invasively via adhesive patches differentiates primary melanomas from atypical nevi and other pigmented lesions with a NPV of over 99%, a sensitivity of 91%, and a specificity of 69%, to help clinicians rule out melanoma and the need for surgical biopsies of atypial pigmented lesions with suspicion for melanoma...
May 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29708969/microdeletion-on-chromosome-8p23-1-in-a-familial-form-of-severe-buruli-ulcer
#6
Quentin B Vincent, Aziz Belkadi, Cindy Fayard, Estelle Marion, Ambroise Adeye, Marie-Françoise Ardant, Christian R Johnson, Didier Agossadou, Lazaro Lorenzo, Julien Guergnon, Christine Bole-Feysot, Jeremy Manry, Patrick Nitschké, Ioannis Theodorou, Jean-Laurent Casanova, Laurent Marsollier, Annick Chauty, Laurent Abel, Alexandre Alcaïs
Buruli ulcer (BU), the third most frequent mycobacteriosis worldwide, is a neglected tropical disease caused by Mycobacterium ulcerans. We report the clinical description and extensive genetic analysis of a consanguineous family from Benin comprising two cases of unusually severe non-ulcerative BU. The index case was the most severe of over 2,000 BU cases treated at the Centre de Dépistage et de Traitement de la Lèpre et de l'Ulcère de Buruli, Pobe, Benin, since its opening in 2003. The infection spread to all limbs with PCR-confirmed skin, bone and joint infections...
April 30, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29650775/mechanotransduction-via-the-linc-complex-regulates-dna-replication-in-myonuclei
#7
Shuoshuo Wang, Elizabeth Stoops, Unnikannan Cp, Barak Markus, Adriana Reuveny, Elly Ordan, Talila Volk
Nuclear mechanotransduction has been implicated in the control of chromatin organization; however, its impact on functional contractile myofibers is unclear. We found that deleting components of the linker of nucleoskeleton and cytoskeleton (LINC) complex in Drosophila melanogaster larval muscles abolishes the controlled and synchronized DNA endoreplication, typical of nuclei across myofibers, resulting in increased and variable DNA content in myonuclei of individual myofibers. Moreover, perturbation of LINC-independent mechanical input after knockdown of β-Integrin in larval muscles similarly led to increased DNA content in myonuclei...
June 4, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29559320/long-non-coding-rna-ror-promotes-radioresistance-in-hepatocelluar-carcinoma-cells-by-acting-as-a-cerna-for-microrna-145-to-regulate-rad18-expression
#8
Ying Chen, Zetian Shen, Yingru Zhi, Hao Zhou, Kai Zhang, Ting Wang, Bing Feng, Yitian Chen, Haizhu Song, Rui Wang, Xiaoyuan Chu
Radiotherapy plays a limited role in the treatment of hepatocellular carcinoma (HCC) due to the development of resistance. Therefore, further investigation of underlying mechanisms involved in HCC radioresistance is warranted. Increasing evidence shows that long non-coding RNAs (linc-RNAs) are involved in the pathology of various tumors, including HCC. Previously, we have shown that long noncoding RNA regulator of reprogramming (linc-ROR) promotes HCC metastasis via induction of epithelial-mesenchymal transition (EMT)...
May 1, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29552776/long-noncoding-rna-linc-ubc1-promotes-tumor-invasion-and-metastasis-by-regulating-ezh2-and-repressing-e-cadherin-in-esophageal-squamous-cell-carcinoma
#9
Guangcai Niu, Huijie Zhuang, Bingqiang Li, Gang Cao
PURPOSE: Recent reports have shown that long noncoding (lnc) RNAs are critical during tumorigenesis. This study focused on the influence of linc-UBC1 on the metastasis of esophageal squamous cell carcinoma (ESCC) and the underlying mechanism. METHODS: In 50 ESCC tissues and 5 ESCC cell lines, linc- UBC1 expression was detected by RT-qPCR. Moreover, correlation analysis was conducted between linc-UBC1 expression level and clinicopathological features. Overall survival of these ESCC patients was analyzed by Kaplan-Meier method...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29482641/transcription-factors-tp73-cebpd-pax6-and-spi1-rather-than-dna-methylation-regulate-chronic-transcriptomics-changes-after-experimental-traumatic-brain-injury
#10
Anssi Lipponen, Assam El-Osta, Antony Kaspi, Mark Ziemann, Ishant Khurana, Harikrishnan Kn, Vicente Navarro-Ferrandis, Noora Puhakka, Jussi Paananen, Asla Pitkänen
Traumatic brain injury (TBI) induces a wide variety of cellular and molecular changes that can continue for days to weeks to months, leading to functional impairments. Currently, there are no pharmacotherapies in clinical use that favorably modify the post-TBI outcome, due in part to limited understanding of the mechanisms of TBI-induced pathologies. Our system biology analysis tested the hypothesis that chronic transcriptomics changes induced by TBI are controlled by altered DNA-methylation in gene promoter areas or by transcription factors...
February 27, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29395921/repression-of-cell-differentiation-by-a-cis-acting-lincrna-in-fission-yeast
#11
Sylvain Fauquenoy, Valerie Migeot, Olivier Finet, Carlo Yague-Sanz, Olga Khorosjutina, Karl Ekwall, Damien Hermand
The cell fate decision leading to gametogenesis requires the convergence of multiple signals on the promoter of a master regulator. In fission yeast, starvation-induced signaling leads to the transcriptional induction of the ste11 gene, which encodes the central inducer of mating and gametogenesis, known as sporulation. We find that the long intergenic non-coding (linc) RNA rse1 is transcribed divergently upstream of the ste11 gene. During vegetative growth, rse1 directly recruits a Mug187-Lid2-Set1 complex that mediates cis repression at the ste11 promoter through SET3C-dependent histone deacetylation...
February 5, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29364044/linc-ram-is-required-for-fgf2-function-in-regulating-myogenic-cell-differentiation
#12
Yixia Zhao, Fengqi Cao, Xiaohua Yu, Chuyan Chen, Jiao Meng, Ran Zhong, Yong Zhang, Dahai Zhu
Myogenic differentiation of skeletal muscle stem cells, also known satellite cells, is tightly orchestrated by extrinsic and intrinsic regulators. Basic fibroblast growth factor (FGF2) is well documented to be implicated in satellite cell self-renewal and differentiation by repressing MyoD. We recently identified a MyoD-regulated and skeletal muscle-specifically expressed long non-coding RNA Linc-RAM which enhances myogenic differentiation by facilitating MyoD/Baf60c/Brg1 complex assembly. Herein, we investigated the transcriptional regulation and intracellular signaling pathway in mediating Linc-RAM gene expression during muscle cell differentiation...
January 24, 2018: RNA Biology
https://www.readbyqxmd.com/read/29336198/long-non-coding-rna-gpr65-1-is-up-regulated-in-gastric-cancer-and-promotes-tumor-growth-through-the-pten-akt-slug-signaling-pathway
#13
Yansen Li, Zhanlong Shen, Bo Wang, Chunxiang Ye, Zhiyong Lai, Hongpeng Jiang, Zhu Wang, Kewei Jiang, Yingjiang Ye, Shan Wang
Increasing evidence has shown that abnormal expression of lncRNAs is involved in various biological behaviors and major cellular pathways of human cancers. However, the role of lncRNAs in the progression of gastric cancer has not been adequately investigated. Therefore, in this study, we investigated the expression levels of linc-GPR65-1 using Quantitative real-time PCR (qRT-PCR) and found that linc-GPR65-1 was significantly up-regulated in 50 gastric cancer tissues compared to the corresponding normal tissues...
April 2, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29310950/expression-and-clinical-role-of-long-non-coding-rna-in-high-grade-serous-carcinoma
#14
Natalie Filippov-Levy, Hallel Cohen-Schussheim, Claes G Tropé, Thea E Hetland Falkenthal, Yoav Smith, Ben Davidson, Reuven Reich
OBJECTIVE: To profile long non-coding RNA (lncRNA) expression at the various anatomic sites of high-grades serous carcinoma (HGSC) and in effusion-derived exosomes. METHODS: LncRNA profiling was performed on 60 HGSC specimens, including 10 ovarian tumors, 10 solid metastases and 10 malignant effusions, as well as exosomes from 30 effusion supernatants. Anatomic site-related expression of ESRG, Link-A, GAS5, MEG3, GATS, PVT1 H19, Linc-RoR, HOTAIR and MALAT1 was validated by quantitative PCR and assessed for clinical relevance in a series of 77 HGSC effusions, 40 ovarian carcinomas, 21 solid metastases and 42 supernatant exosomes...
March 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29299144/lincrna00273-promotes-cancer-metastasis-and-its-g-quadruplex-promoter-can-serve-as-a-novel-target-to-inhibit-cancer-invasiveness
#15
Samarjit Jana, Jagannath Jana, Kartick Patra, Soma Mondal, Jyotsna Bhat, Arnab Sarkar, Pallabi Sengupta, Anindya Biswas, Meghomukta Mukherjee, Satya Prakash Tripathi, Rahul Gangwal, Joyita Hazra, Abhay T Sangamwar, Gopeswar Mukherjee, Shamee Bhattacharjee, Deba Prasad Mandal, Subhrangsu Chatterjee
Discovery of anti-metastatic drugs is of immense clinical significance as metastasis is responsible for 90% of all cancer deaths. Here we report the inhibitory effect of a bis schiff base (M2) on cancer cell migration and invasion in vitro and in vivo . M2 has shown good solubility and permeability across the intestinal cell wall and hence can be classified as BCS (Biopharmaceutical classification system) class I. Microarray studies identified a long non coding intergenic RNA, LINC00273 as a novel molecular target of M2...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29280051/long-non-coding-rna-linc-ror-is-upregulated-in-papillary-thyroid-carcinoma
#16
Ranran Zhang, Heather Hardin, Wei Huang, Darya Buehler, Ricardo V Lloyd
Long non-coding RNAs (lncRNAs) may contribute to carcinogenesis and tumor progression by regulating transcription and gene expression. The role of lncRNAs in the regulation of thyroid cancer progression is being extensively examined. Here, we analyzed three lncRNAs that were overexpressed in papillary thyroid carcinomas, long intergenic non-protein coding RNA, regulator of reprogramming (Linc-ROR, ROR) PVT1 oncogene (PVT1), and HOX transcript antisense intergenic RNA (HOTAIR) to determine their roles in thyroid tumor development and progression...
March 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29237490/linc-ror-promotes-esophageal-squamous-cell-carcinoma-progression-through-the-derepression-of-sox9
#17
Lianghai Wang, Xiaodan Yu, Zhiyu Zhang, Lijuan Pang, Jiang Xu, Jinfang Jiang, Weihua Liang, Yuhang Chai, Jun Hou, Feng Li
BACKGROUND: Novel therapies tailored to the molecular composition of esophageal squamous cell carcinoma (ESCC) are needed to improve patient survival. We investigated the regulatory network of long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) and sex-determining region Y-box 9 (SOX9), and their therapeutic relevance in ESCC. METHODS: Linc-ROR and SOX9 expression were examined in ESCC specimens, cell lines, and cultured tumorspheres. We investigated the effects of linc-ROR on SOX9 expression and malignant phenotypes by CCK8, colony formation, Transwell, and sphere-forming assay...
December 13, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29228420/knockdown-of-long-noncoding-rna-linc-itgb1-suppresses-migration-invasion-of-hepatocellular-carcinoma-via-regulating-zeb1
#18
W-W Yu, K Wang, G-J Liao
OBJECTIVE: This research focuses on the influence of linc-ITGB1 on the metastasis of hepatocellular carcinoma and further explores its underlying mechanism. PATIENTS AND METHODS: A total of 70 hepatocellular carcinoma patients were chosen for our study. RT-qPCR was used for detecting the expression level of linc-ITGB1 in their cancer tissues. Moreover, the expression level of linc-ITGB1 was also detected in hepatocellular carcinoma cell lines. Furthermore, whether linc-ITGB1 could affect the migrated and invaded ability of hepatocellular carcinoma cells was determined by wound healing assay and transwell assay...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29207090/long-intergenic-non%C3%A2-coding-rna%C3%A2-p21-mediates-cardiac-senescence-via-the-wnt-%C3%AE-%C3%A2-catenin-signaling-pathway-in-doxorubicin-induced-cardiotoxicity
#19
Zhongdong Xie, Wenzheng Xia, Meng Hou
Doxorubicin (Dox)-induced cardiotoxicity has been a well‑known phenomenon to clinicians and scientists for decades. It has been confirmed that Dox‑dependent cardiotoxicity is accompanied by cardiac cellular senescence. However, the molecular mechanisms underlying Dox cardiotoxicity remains to be fully elucidated. Long non‑coding (lnc) RNAs regulate gene transcription and the fate of post‑transcriptional mRNA, which affects a broad range of age‑associated physiological and pathological conditions, including cardiovascular disease and cellular senescence...
February 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29201168/long-non-coding-rna-linc-itgb1-promotes-cell-proliferation-and-migration-in-human-hepatocellular-carcinoma-cells
#20
Meiling Shang, Xinhua Xu, Min Zhang, Hongyuan Yang
Hepatocellular carcinoma (HCC) represents a major endpoint of chronic liver diseases and is the third leading cause of cancer-related mortality. Long intergenic non-coding RNA-integrin subunit β1 ITGB1 (linc-ITGB1) is a novel long non-coding RNA, which is implicated in the development and progression of human tumors. However, its involvement in hepatocarcinogenesis remains to be elucidated. In the present study, the specific roles of linc-ITGB1 on cell proliferation and metastasis in HCC were investigated...
November 2017: Experimental and Therapeutic Medicine
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