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3D printing medicine

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https://www.readbyqxmd.com/read/28929219/3d-printing-for-clinical-application-in-otorhinolaryngology
#1
REVIEW
Nongping Zhong, Xia Zhao
Three-dimensional (3D) printing is a promising technology that can use a patient's image data to create complex and personalized constructs precisely. It has made great progress over the past few decades and has been widely used in medicine including medical modeling, surgical planning, medical education and training, prosthesis and implants. Three-dimensional (3D) bioprinting is a powerful tool that has the potential to fabricate bioengineered constructs of the desired shape layer-by-layer using computer-aided deposition of living cells and biomaterials...
September 19, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28888978/fabrication-of-drug-loaded-hydrogels-with-stereolithographic-3d-printing
#2
Pamela Robles Martinez, Alvaro Goyanes, Abdul W Basit, Simon Gaisford
3D printing (3DP) technologies have been attracting much recent interest as new methods of fabricating medicines and medical devices. Of the many types of 3DP available, stereolithographic (SLA) printing offers the unique advantage of being able to fabricate objects by cross-linking resins to form networked polymer matrices. Because water can be entrapped in these matrices, it is possible in principle to fabricate pre-wetted, drug-loaded hydrogels and devices. Here, SLA printing was used to prepare ibuprofen-loaded hydrogels of cross-linked polyethylene glycol diacrylate...
September 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28876895/3d-printing-of-photocurable-cellulose-nanocrystal-composite-for-fabrication-of-complex-architectures-via-stereolithography
#3
Napolabel Palaganas, Joey Mangadlao, Al Christopher De Leon, Jerome Palaganas, Katrina Pangilinan, Yan Jie Lee, Rigoberto Advincula
The advantages of 3D printing on cost, speed, accuracy, and flexibility have attracted several new applications in various industries especially in the field of medicine where customized solutions are highly demanded. Although this modern fabrication technique offers several benefits, it also poses critical challenges in materials development suitable for industry use. Proliferation of polymers in biomedical application has been severely limited by their inherently weak mechanical properties despite their other excellent attributes...
September 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28842703/in-situ-repair-of-bone-and-cartilage-defects-using-3d-scanning-and-3d-printing
#4
Lan Li, Fei Yu, Jianping Shi, Sheng Shen, Huajian Teng, Jiquan Yang, Xingsong Wang, Qing Jiang
Three-dimensional (3D) printing is a rapidly emerging technology that promises to transform tissue engineering into a commercially successful biomedical industry. However, the use of robotic bioprinters alone is not sufficient for disease treatment. This study aimed to report the combined application of 3D scanning and 3D printing for treating bone and cartilage defects. Three different kinds of defect models were created to mimic three orthopedic diseases: large segmental defects of long bones, free-form fracture of femoral condyle, and International Cartilage Repair Society grade IV chondral lesion...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28838640/emerging-role-of-three-dimensional-printing-in-simulation-in-otolaryngology
#5
REVIEW
Kyle K VanKoevering, Kelly Michele Malloy
Simulation is rapidly expanding across medicine as a valuable component of trainee education. For procedural simulation, development of low-cost simulators that allow a realistic, haptic experience for learners to practice maneuvers while appreciating anatomy has become highly valuable. Otolaryngology has seen significant advancements in development of improved, specialty-specific simulators with the expansion of three-dimensional (3D) printing. This article highlights the fundamental components of 3D printing and the multitude of subspecialty simulators that have been developed with the assistance of 3D printing...
August 21, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28813592/3d-printed-phema-materials-for-topographical-and-biochemical-modulation-of-dorsal-root-ganglion-cell-response
#6
Adina Badea, Joselle M McCracken, Emily G Tillmaand, Mikhail E Kandel, Aaron W Oraham, Molly B Mevis, Stanislav S Rubakhin, Gabriel Popescu, Jonathan V Sweedler, Ralph G Nuzzo
Understanding and controlling the interactions occurring between cells and engineered materials are central challenges toward progress in the development of biomedical devices. In this work, we describe materials for direct ink writing (DIW), an extrusion-based type of 3D printing, that embed a custom synthetic protein (RGD-PDL) within the microfilaments of 3D-hydrogel scaffolds to modify these interactions and differentially direct tissue-level organization of complex cell populations in vitro. The RGD-PDL is synthesized by modifying poly-d-lysine (PDL) to varying extents with peptides containing the integrin-binding motif Arg-Gly-Asp (RGD)...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28800287/measuring-and-establishing-the-accuracy-and-reproducibility-of-3d-printed-medical-models
#7
Elizabeth George, Peter Liacouras, Frank J Rybicki, Dimitrios Mitsouras
Despite the rapid growth of three-dimensional (3D) printing applications in medicine, the accuracy and reproducibility of 3D printed medical models have not been thoroughly investigated. Although current technologies enable 3D models to be created with accuracy within the limits of clinical imaging spatial resolutions, this is not always achieved in practice. Inaccuracies are due to errors that occur during the imaging, segmentation, postprocessing, and 3D printing steps. Radiologists' understanding of the factors that influence 3D printed model accuracy and the metrics used to measure this accuracy is key in directing appropriate practices and establishing reference standards and validation procedures...
September 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28797120/medication-eluting-devices-for-the-field-of-obgyn-medobgyn-3d-printed-biodegradable-hormone-eluting-constructs-a-proof-of-concept-study
#8
Karthik Tappa, Udayabhanu Jammalamadaka, David H Ballard, Todd Bruno, Marissa R Israel, Harika Vemula, J Mark Meacham, David K Mills, Pamela K Woodard, Jeffery A Weisman
3D printing has the potential to deliver personalized implants and devices for obstetric and gynecologic applications. The aim of this study is to engineer customizable and biodegradable 3D printed implant materials that can elute estrogen and/or progesterone. All 3D constructs were printed using polycaprolactone (PCL) biodegradable polymer laden with estrogen or progesterone and were subjected to hormone-release profile studies using ELISA kits. Material thermal properties were tested using thermogravimetric analysis and differential scanning calorimetry...
2017: PloS One
https://www.readbyqxmd.com/read/28790931/microtissues-enhance-smooth-muscle-differentiation-and-cell-viability-of-hadscs-for-three-dimensional-bioprinting
#9
Jin Yipeng, Xu Yongde, Wu Yuanyi, Sun Jilei, Guo Jiaxiang, Gao Jiangping, Yang Yong
Smooth muscle differentiated human adipose derived stem cells (hADSCs) provide a crucial stem cell source for urinary tissue engineering, but the induction of hADSCs for smooth muscle differentiation still has several issues to overcome, including a relatively long induction time and equipment dependence, which limits access to abundant stem cells within a short period of time for further application. Three-dimensional (3D) bioprinting holds great promise in regenerative medicine due to its controllable construction of a designed 3D structure...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28782725/the-bio-in-the-ink-cartilage-regeneration-with-bioprintable-hydrogels-and-articular-cartilage-derived-progenitor-cells
#10
Riccardo Levato, William R Webb, Iris A Otto, Anneloes Mensinga, Yadan Zhang, Mattie van Rijen, René van Weeren, Ilyas M Khan, Jos Malda
Cell-laden hydrogels are the primary building blocks for bioprinting, and, also termed bioinks, are the foundations for creating structures that can potentially recapitulate the architecture of articular cartilage. To be functional, hydrogel constructs need to unlock the regenerative capacity of encapsulated cells. The recent identification of multipotent articular cartilage-resident chondroprogenitor cells (ACPCs), which share important traits with adult stem cells, represents a new opportunity for cartilage regeneration...
August 4, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28780275/inhalable-sirna-loaded-nano-embedded-microparticles-engineered-using-microfluidics-and-spray-drying
#11
Monica Agnoletti, Adam Bohr, Kaushik Thanki, Feng Wan, Xianghui Zeng, Johan Peter Boetker, Mingshi Yang, Camilla Foged
Medicines based on small interfering RNA (siRNA) are promising for the treatment of a number of lung diseases. However, efficient delivery systems and design of stable dosage forms are required for inhalation therapy, as well as cost-effective methods for manufacturing of the final product. In this study, a 3D-printed micromixer was used for preparation of siRNA-dendrimer nanocomplexes, which were subsequently processed into microparticle-based dry powders for inhalation using spray drying. By applying the disposable micromixer, nanocomplexes were prepared of an average hydrodynamic diameter comparable to that of nanocomplexes prepared by manual mixing, but with narrower size distribution and low batch-to-batch variation...
August 2, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28773924/3d-bioprinting-technologies-for-hard-tissue-and-organ-engineering
#12
REVIEW
Xiaohong Wang, Qiang Ao, Xiaohong Tian, Jun Fan, Yujun Wei, Weijian Hou, Hao Tong, Shuling Bai
Hard tissues and organs, including the bones, teeth and cartilage, are the most extensively exploited and rapidly developed areas in regenerative medicine field. One prominent character of hard tissues and organs is that their extracellular matrices mineralize to withstand weight and pressure. Over the last two decades, a wide variety of 3D printing technologies have been adapted to hard tissue and organ engineering. These 3D printing technologies have been defined as 3D bioprinting. Especially for hard organ regeneration, a series of new theories, strategies and protocols have been proposed...
September 27, 2016: Materials
https://www.readbyqxmd.com/read/28759433/engineering-derived-approaches-for-ipsc-preparation-expansion-differentiation-and-applications
#13
Yang Li, Ling Li, Zhi-Nan Chen, Ge Gao, Rui Yao, Wei Sun
Remarkable achievements have been made since induced pluripotent stem cells (iPSCs) were first introduced in 2006. Compared with non-pluripotent stem cells, iPSC research faces several additional complexities, such as the choice of extracellular matrix proteins, growth and differentiation factors, as well as technical challenges related to self-renewal and directed differentiation. Overcoming these challenges requires the integration of knowledge and technologies from multiple fields including cell biology, biomaterial science, engineering, physics and medicine...
July 31, 2017: Biofabrication
https://www.readbyqxmd.com/read/28756658/polymers-for-3d-printing-and-customized-additive-manufacturing
#14
Samuel Clark Ligon, Robert Liska, Jürgen Stampfl, Matthias Gurr, Rolf Mülhaupt
Additive manufacturing (AM) alias 3D printing translates computer-aided design (CAD) virtual 3D models into physical objects. By digital slicing of CAD, 3D scan, or tomography data, AM builds objects layer by layer without the need for molds or machining. AM enables decentralized fabrication of customized objects on demand by exploiting digital information storage and retrieval via the Internet. The ongoing transition from rapid prototyping to rapid manufacturing prompts new challenges for mechanical engineers and materials scientists alike...
August 9, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28750894/patient-acceptability-of-3d-printed-medicines
#15
Alvaro Goyanes, Mariagiovanna Scarpa, Michael Kamlow, Simon Gaisford, Abdul W Basit, Mine Orlu
Patient-centric medicine is a derivative term for personalised medicine, whereby the pharmaceutical product provides the best overall benefit by meeting the comprehensive needs of the individual; considering the end-user from the beginning of the formulation design process right through development to an end product is a must. One way in which to obtain personalised medicines, on-site and on-demand is by three-dimensional printing (3DP). The aim of this study was to investigate the influence of the shape, size and colour of different placebo 3D printed tablets (Printlets™) manufactured by fused deposition modelling (FDM) 3DP on end-user acceptability regarding picking and swallowing...
July 24, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28739852/3d-printing-set-to-revolutionize-medicine
#16
Carolyn Brown
No abstract text is available yet for this article.
July 24, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28729190/systematic-review-of-the-use-of-3-dimensional-printing-in-surgical-teaching-and-assessment
#17
Benjamin Langridge, Sheikh Momin, Ben Coumbe, Evelina Woin, Michelle Griffin, Peter Butler
OBJECTIVE: The use of 3-dimensional (3D) printing in medicine has rapidly expanded in recent years as the technology has developed. The potential uses of 3D printing are manifold. This article provides a systematic review of the uses of 3D printing within surgical training and assessment. METHODS: A structured literature search of the major literature databases was performed in adherence to PRISMA guidelines. Articles that met predefined inclusion and exclusion criteria were appraised with respect to the key objectives of the review and sources of bias were analysed...
July 17, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28719987/corrective-osteotomy-of-malunited-diaphyseal-fractures-of-the-forearm-simplified-using-3-dimensional-ct-data-proposal-of-our-simple-strategy-through-case-presentation
#18
Yoshitaka Hamada, Hiroyuki Gotani, Kousuke Sasaki, Yoshitaka Tanaka, Hiroshi Egawa, Thepparat Kanchanathepsak
BACKGROUND: Reconstruction of malunited diaphyseal fractures of the forearm is one of the most difficult treatments due to its complicated structure. Widespread usage of Digital Imaging and Communications in Medicine (DICOM) data of 3-dimensional (3D) computed tomography (CT) and 3D printing can make estimating the true plane of the deformity easy. METHODS: A 21-year-old man with limited supination due to left forearm nonunion deformity initially treated by locking plate fixation was referred to our hospital...
September 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28712105/evaluation-of-a-low-cost-3d-printed-model-for-bronchoscopy-training
#19
Matteo Parotto, Joshua Qua Jiansen, Ahmed AboTaiban, Svetlana Ioukhova, Alisher Agzamov, Richard Cooper, Gerald O'Leary, Massimiliano Meineri
BACKGROUND: Flexible bronchoscopy is a fundamental procedure in anaesthesia and critical care medicine. Although learning this procedure is a complex task, the use of simulation-based training provides significant advantages, such as enhanced patient safety. Access to bronchoscopy simulators may be limited in low-resource settings. We have developed a low-cost 3D-printed bronchoscopy training model. METHODS: A parametric airway model was obtained from an online medical model repository and fabricated using a low-cost 3D printer...
2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28688288/enhanced-osteogenic-activity-of-poly-ester-urea-scaffolds-using-facile-post-3d-printing-peptide-functionalization-strategies
#20
Shan Li, Yanyi Xu, Jiayi Yu, Matthew L Becker
Additive manufacturing has the potential to revolutionize regenerative medicine, but the harsh thermal or photochemical conditions during the 3D printing process limit the inclusion of drugs, growth factors and other biologics within the resulting scaffolds. Functionalization strategies that enable specific placement of bioactive species on the surface of 3D printed structures following the printing process afford a promising approach to sidestep the harsh conditions and incorporate these valuable bioactive molecules with precise control over concentration...
June 28, 2017: Biomaterials
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