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3D printing medicine

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https://www.readbyqxmd.com/read/29122434/a-method-of-accurate-bone-tunnel-placement-for-anterior-cruciate-ligament-reconstruction-based-on-3-dimensional-printing-technology-a-cadaveric-study
#1
Jianlong Ni, Dichen Li, Mao Mao, Xiaoqian Dang, Kunzheng Wang, Jiankang He, Zhibin Shi
PURPOSE: To explore a method of bone tunnel placement for anterior cruciate ligament (ACL) reconstruction based on 3-dimensional (3D) printing technology and to assess its accuracy. METHODS: Twenty human cadaveric knees were scanned by thin-layer computed tomography (CT). To obtain data on bones used to establish a knee joint model by computer software, customized bone anchors were installed before CT. The reference point was determined at the femoral and tibial footprint areas of the ACL...
November 6, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29111891/regenerative-medicine-in-india-trends-and-challenges-in-innovation-and-regulation
#2
Shashank S Tiwari, Sujatha Raman, Paul Martin
The government of India has heavily promoted research and development in regenerative medicine together with domestic innovation and business development initiatives. Together, these promise a revolution in healthcare and public empowerment in India. Several national and transnational linkages have emerged to develop innovative capacity, most prominently in stem cell and cord blood banking, as well as in gene therapy, tissue engineering, biomaterials and 3D printing. However, challenges remain of achieving regulatory oversight, viable outputs and equitable impacts...
November 7, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/29107127/cyclodextrins-as-versatile-building-blocks-for-regenerative-medicine
#3
REVIEW
Carmen Alvarez-Lorenzo, Carlos A García-González, Angel Concheiro
Cyclodextrins (CDs) are one of the most versatile substances produced by nature, and it is in the aqueous biological environment where the multifaceted potential of CDs can be completely unveiled. CDs form inclusion complexes with a variety of guest molecules, including polymers, producing very diverse biocompatible supramolecular structures. Additionally, CDs themselves can trigger cell differentiation to distinct lineages depending on the substituent groups and also promote salt nucleation. These features together with the affinity-driven regulated release of therapeutic molecules, growth factors and gene vectors explain the rising interest for CDs as building blocks in regenerative medicine...
October 26, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29091482/image-once-print-thrice-three-dimensional-printing-of-replacement-parts
#4
Timothy M Rankin, Blair A Wormer, John D Miller, Nicholas A Giovinco, Salam Al Kassis, David G Armstrong
OBJECTIVE: The last 20 years has seen an exponential increase in 3D printing as it pertains to the medical industry and more specifically surgery. Previous reviews in this domain have chosen to focus on applications within a specific field. To our knowledge none have evaluated the broad applications of patient-specific or Digital Imaging and Communications in Medicine (DICOM) derived applications of this technology. METHODS: We searched PUBMED and CINAHL from April 2012 up to April 2017...
November 1, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29064532/a-review-of-the-application-of-reinforced-hydrogels-and-silk-as-biomaterials-for-intervertebral-disc-repair
#5
D A Frauchiger, A Tekari, M Wöltje, G Fortunato, L M Benneker, B Gantenbein
The degeneration of the intervertebral disc (IVD) within the spinal column represents a major pain source for many patients. Biological restoration or repair of the IVD using "compressive-force-resistant" and at the same time "cytocompatible" materials would be desirable over current purely mechanical solutions, such as spinal fusion or IVD implants. This review provides an overview of recent research on the repair of the inner (nucleus pulposus = NP) and the outer (annulus fibrous = AF) parts of the IVD tissue...
October 24, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/29058219/lemrg-decision-rule-generation-algorithm-for-mining-microrna-expression-data
#6
Łukasz Piątek, Jerzy W Grzymała-Busse
Recently, research on mining microRNA (or miRNA) expression data has received a lot of attention, mainly because of its role in gene regulation. However, such type of data - usually saved in the form of microarrays - are very specific, because they contain only a small number of cases (often less than 100) compared with large number of attributes (equal to several hundreds or even tens of thousand). The small number of cases available during the learning process can cause instability of the newly created classifiers...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29057187/modelling-and-manufacturing-of-a-3d-printed-trachea-for-cricothyroidotomy-simulation
#7
Gregory Doucet, Stephen Ryan, Michael Bartellas, Michael Parsons, Adam Dubrowski, Tia Renouf
Cricothyroidotomy is a life-saving medical procedure that allows for tracheal intubation. Most current cricothyroidotomy simulation models are either expensive or not anatomically accurate and provide the learner with an unrealistic simulation experience. The goal of this project is to improve current simulation techniques by utilizing rapid prototyping using 3D printing technology and expert opinions to develop inexpensive and anatomically accurate trachea simulators. In doing so, emergency cricothyroidotomy simulation can be made accessible, accurate, cost-effective and reproducible...
August 18, 2017: Curēus
https://www.readbyqxmd.com/read/29042960/application-of-3d-printing-rapid-prototyping-assisted-percutaneous-fixation-in-the-treatment-of-intertrochanteric-fracture
#8
Sheng-Nai Zheng, Qing-Qiang Yao, Feng-Yong Mao, Peng-Fei Zheng, Shu-Chang Tian, Jia-Yi Li, Yi-Fan Yu, Shuai Liu, Jin Zhou, Jun Hu, Yan Xu, Kai Tang, Yue Lou, Li-Ming Wang
The aim of the present study was to investigate the application of 3D printing (3DP) rapid prototyping (RP) technique-assisted percutaneous fixation in the treatment of femoral intertrochanteric fracture (ITF) using proximal femoral nail anti-rotation (PFNA). A total of 39 patients with unstable ITF were included in the current study. Patients were divided into two groups: 19 patients were examined using computed tomography scanning and underwent PFNA with SDP-RP whereas the other 20 patients underwent conventional PFNA treatment...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28985202/3d-bioprinting-using-stem-cells
#9
REVIEW
Chin Siang Ong, Pooja Yesantharao, Chen Yu Huang, Gunnar Mattson, Joseph Boktor, Takuma Fukunishi, Huaitao Zhang, Narutoshi Hibino
Recent advances have allowed for three-dimensional (3D) printing technologies to be applied to biocompatible materials, cells and supporting components, creating a field of 3D bioprinting that holds great promise for artificial organ printing and regenerative medicine. At the same time, stem cells, such as human induced pluripotent stem cells, have driven a paradigm shift in tissue regeneration and the modeling of human disease, and represent an unlimited cell source for tissue regeneration and the study of human disease...
October 6, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28971093/antimicrobial-peptides-in-biomedical-device-manufacturing
#10
REVIEW
Martijn Riool, Anna de Breij, Jan W Drijfhout, Peter H Nibbering, Sebastian A J Zaat
Over the past decades the use of medical devices, such as catheters, artificial heart valves, prosthetic joints, and other implants, has grown significantly. Despite continuous improvements in device design, surgical procedures, and wound care, biomaterial-associated infections (BAI) are still a major problem in modern medicine. Conventional antibiotic treatment often fails due to the low levels of antibiotic at the site of infection. The presence of biofilms on the biomaterial and/or the multidrug-resistant phenotype of the bacteria further impair the efficacy of antibiotic treatment...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28966386/laparoscopic-acetabular-fracture-fixation-after-three-dimensional-modelling-and-printing
#11
Can-Jun Zeng, Wen-Hua Huang, Hua-Jun Huang, Zhang-Lin Wu
Current surgical treatment of acetabular fractures is open reduction and internal fixation and requires a large incision resulting in considerable blood loss and a potentially long duration of recovery. We report a case of an acetabular fracture that received laparoscopic internal fixation after three-dimensional (3D) modelling and printing of the acetabulum. A 43 year old male fell from a height of 3 m resulting in a right acetabulum anterior column fracture. Thin section computed tomography scanning with 0...
September 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28952558/personalised-3d-printed-medicines-which-techniques-and-polymers-are-more-successful
#12
REVIEW
Andrea Alice Konta, Marta García-Piña, Dolores R Serrano
The interindividual variability is an increasingly global problem when treating patients from different backgrounds with diverse customs, metabolism, and necessities. Dose adjustment is frequently based on empirical methods, and therefore, the chance of undesirable side effects to occur is high. Three-dimensional (3D) Printed medicines are revolutionsing the pharmaceutical market as potential tools to achieve personalised treatments adapted to the specific requirements of each patient, taking into account their age, weight, comorbidities, pharmacogenetic, and pharmacokinetic characteristics...
September 22, 2017: Bioengineering
https://www.readbyqxmd.com/read/28952550/3d-bioprinting-and-in-vitro-cardiovascular-tissue-modeling
#13
REVIEW
Jinah Jang
Numerous microfabrication approaches have been developed to recapitulate morphologically and functionally organized tissue microarchitectures in vitro; however, the technical and operational limitations remain to be overcome. 3D printing technology facilitates the building of a construct containing biomaterials and cells in desired organizations and shapes that have physiologically relevant geometry, complexity, and micro-environmental cues. The selection of biomaterials for 3D printing is considered one of the most critical factors to achieve tissue function...
August 18, 2017: Bioengineering
https://www.readbyqxmd.com/read/28952542/3d-printing-and-3d-bioprinting-in-pediatrics
#14
Sanjairaj Vijayavenkataraman, Jerry Y H Fuh, Wen Feng Lu
Additive manufacturing, commonly referred to as 3D printing, is a technology that builds three-dimensional structures and components layer by layer. Bioprinting is the use of 3D printing technology to fabricate tissue constructs for regenerative medicine from cell-laden bio-inks. 3D printing and bioprinting have huge potential in revolutionizing the field of tissue engineering and regenerative medicine. This paper reviews the application of 3D printing and bioprinting in the field of pediatrics.
July 13, 2017: Bioengineering
https://www.readbyqxmd.com/read/28952490/photocurable-bioink-for-the-inkjet-3d-pharming-of-hydrophilic-drugs
#15
Giovanny F Acosta-Vélez, Chase S Linsley, Madison C Craig, Benjamin M Wu
Novel strategies are required to manufacture customized oral solid dosage forms for personalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets, is an attractive strategy, since it allows for the rapid production of solid dosage forms containing custom drug dosages. This study reports on the design and characterization of a biocompatible photocurable pharmaceutical polymer for inkjet 3D printing that is suitable for hydrophilic active pharmaceutical ingredients (API). Specifically, hyaluronic acid was functionalized with norbornene moieties that, in the presence of poly(ethylene) glycol dithiol, Eosin Y as a photoinitiator, and a visible light source, undergoes a rapid step-growth polymerization reaction through thiol-ene chemistry...
January 28, 2017: Bioengineering
https://www.readbyqxmd.com/read/28938849/animal-models-in-tissue-engineering-part-i
#16
Jorge A Piedrahita, J Koudy Williams
Animal models play a central and pivotal role in tissue engineering. Although advances in areas such as 3D printing and bioreactor technologies now permit the in vitro development and testing of complex scaffold/cell composites, in vivo testing remains critical not only for refining methods being developed but also for the critical efficacy and safety testing required for regulatory approval. Yet, choosing the appropriate model for a particular application remains a challenge, as each model has its own strengths and weaknesses...
November 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28929219/3d-printing-for-clinical-application-in-otorhinolaryngology
#17
REVIEW
Nongping Zhong, Xia Zhao
Three-dimensional (3D) printing is a promising technology that can use a patient's image data to create complex and personalized constructs precisely. It has made great progress over the past few decades and has been widely used in medicine including medical modeling, surgical planning, medical education and training, prosthesis and implants. Three-dimensional (3D) bioprinting is a powerful tool that has the potential to fabricate bioengineered constructs of the desired shape layer-by-layer using computer-aided deposition of living cells and biomaterials...
December 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28888978/fabrication-of-drug-loaded-hydrogels-with-stereolithographic-3d-printing
#18
Pamela Robles Martinez, Alvaro Goyanes, Abdul W Basit, Simon Gaisford
3D printing (3DP) technologies have been attracting much recent interest as new methods of fabricating medicines and medical devices. Of the many types of 3DP available, stereolithographic (SLA) printing offers the unique advantage of being able to fabricate objects by cross-linking resins to form networked polymer matrices. Because water can be entrapped in these matrices, it is possible in principle to fabricate pre-wetted, drug-loaded hydrogels and devices. Here, SLA printing was used to prepare ibuprofen-loaded hydrogels of cross-linked polyethylene glycol diacrylate...
September 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28876895/3d-printing-of-photocurable-cellulose-nanocrystal-composite-for-fabrication-of-complex-architectures-via-stereolithography
#19
Napolabel B Palaganas, Joey Dacula Mangadlao, Al Christopher C de Leon, Jerome O Palaganas, Katrina D Pangilinan, Yan Jie Lee, Rigoberto C Advincula
The advantages of 3D printing on cost, speed, accuracy, and flexibility have attracted several new applications in various industries especially in the field of medicine where customized solutions are highly demanded. Although this modern fabrication technique offers several benefits, it also poses critical challenges in materials development suitable for industry use. Proliferation of polymers in biomedical application has been severely limited by their inherently weak mechanical properties despite their other excellent attributes...
October 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28842703/in-situ-repair-of-bone-and-cartilage-defects-using-3d-scanning-and-3d-printing
#20
Lan Li, Fei Yu, Jianping Shi, Sheng Shen, Huajian Teng, Jiquan Yang, Xingsong Wang, Qing Jiang
Three-dimensional (3D) printing is a rapidly emerging technology that promises to transform tissue engineering into a commercially successful biomedical industry. However, the use of robotic bioprinters alone is not sufficient for disease treatment. This study aimed to report the combined application of 3D scanning and 3D printing for treating bone and cartilage defects. Three different kinds of defect models were created to mimic three orthopedic diseases: large segmental defects of long bones, free-form fracture of femoral condyle, and International Cartilage Repair Society grade IV chondral lesion...
August 25, 2017: Scientific Reports
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