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3D printing medicine

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https://www.readbyqxmd.com/read/29770294/three-dimensional-modelling-and-three-dimensional-printing-in-pediatric-and-congenital-cardiac-surgery
#1
REVIEW
Laszlo Kiraly
Three-dimensional (3D) modelling and printing methods greatly support advances in individualized medicine and surgery. In pediatric and congenital cardiac surgery, personalized imaging and 3D modelling presents with a range of advantages, e.g., better understanding of complex anatomy, interactivity and hands-on approach, possibility for preoperative surgical planning and virtual surgery, ability to assess expected results, and improved communication within the multidisciplinary team and with patients. 3D virtual and printed models often add important new anatomical findings and prompt alternative operative scenarios...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29755838/application-of-laser-scanning-confocal-microscopy-in-the-soft-tissue-exquisite-structure-for-3d-scan
#2
REVIEW
Zhaoqiang Zhang, Mohamed Ibrahim, Yang Fu, Xujia Wu, Fei Ren, Lei Chen
Three-dimensional (3D) printing is a new developing technology for printing individualized materials swiftly and precisely in the field of biological medicine (especially tissue-engineered materials). Prior to printing, it is necessary to scan the structure of the natural biological tissue, then construct the 3D printing digital model through optimizing the scanned data. By searching the literatures, magazines at home and abroad, this article reviewed the current status, main processes and matters needing attention of confocal laser scanning microscope (LSCM) in the application of soft tissue fine structure 3D scanning, empathizing the significance of LSCM in this field...
2018: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/29753139/a-review-on-fabricating-tissue-scaffolds-using-vat-photopolymerization
#3
REVIEW
Nicholas A Chartrain, Christopher B Williams, Abby R Whittington
Vat Photopolymerization (stereolithography, SLA), an Additive Manufacturing (AM) or 3D printing technology, holds particular promise for the fabrication of tissue scaffolds for use in regenerative medicine. Unlike traditional tissue scaffold fabrication techniques, SLA is capable of fabricating designed scaffolds through the selective photopolymerization of a photopolymer resin on the micron scale. SLA offers unprecedented control over scaffold porosity and permeability, as well as pore size, shape, and interconnectivity...
May 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29752120/effects-of-printing-induced-interfaces-on-localized-strain-within-3d-printed-hydrogel-structures
#4
Kyle Christensen, Brian Davis, Yifei Jin, Yong Huang
Additive manufacturing, or 3D printing, is a promising approach for the fabrication of biological structures for regenerative medicine applications using tissue-like materials such as hydrogels. Herein, inkjet printing is implemented as a model droplet-based 3D printing technology for which interfaces have been shown to form between printed lines within printed layers of hydrogel structures. Experimental samples with interfaces in two orientations are fabricated by inkjet printing and control samples with and without interfaces are fabricated by extrusion printing and casting, respectively...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29745321/selected-applications-for-current-polymers-in-prosthetic-dentistry-state-of-the-art
#5
Maciej Kawala, Joanna Smardz, Lukasz Adamczyk, Natalia Grychowska, Mieszko Wieckiewicz
BACKGROUND: Polymers are widely applied in medicine, including dentistry, i.e. in prosthodontics. AIM: The following paper is aimed at demonstrating the applications of selected modern polymers in prosthetic dentistry based on the reported literature. MATERIAL AND METHODS: The study was conducted using the PubMed, SCOPUS and CINAHL databases in relation to documents published during 1999-2017. The following keywords were used: polymers with: prosthetic dentistry, impression materials, denture base materials, bite registration materials, denture soft liners, occlusal splint materials and 3D printing...
May 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29729295/electrospinning-an-enabling-nanotechnology-platform-for-drug-delivery-and-regenerative-medicine
#6
Shixuan Chen, Ruiquan Li, Xiaoran Li, Jingwei Xie
Electrospinning provides an enabling nanotechnology platform for generating a rich variety of novel structured materials in many biomedical applications including drug delivery, biosensing, tissue engineering, and regenerative medicine. In this review article, we begin with a thorough discussion on the method of producing 1D, 2D, and 3D electrospun nanofiber materials. In particular, we emphasize on how the 3D printing technology can contribute to the improvement of traditional electrospinning technology for the fabrication of 3D electrospun nanofiber materials as drug delivery devices/implants, scaffolds or living tissue constructs...
May 2, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29722634/reverse-engineered-silk-hydrogels-for-cell-and-drug-delivery
#7
F Philipp Seib
Silk is an important biopolymer for (bio)medical applications because of its unique and highly versatile structure and its robust clinical track record in human medicine. Silk can be processed into many material formats, including physically and chemically cross-linked hydrogels that have almost limitless applications ranging from tissue engineering to biomedical imaging and sensing. This concise review provides a detailed background of silk hydrogels, including silk structure-function relationships, biocompatibility and biodegradation, and it explores recent developments in silk hydrogel utilization, with specific reference to drug and cell delivery...
May 1, 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29713420/emergence-of-three-dimensional-printing-technology-and-its-utility-in-spine-surgery
#8
REVIEW
Akshay Gadia, Kunal Shah, Abhay Nene
In the last decade, spine surgery has advanced tremendously. Tissue engineering and three-dimensional (3D) printing/additive manufacturing have provided promising new research avenues in the fields of medicine and orthopedics in recent literature, and their emergent role in spine surgery is encouraging. We reviewed recent articles that highlighted the role of 3D printing in medicine, orthopedics, and spine surgery and summarized the utility of 3D printing. 3D printing has shown promising results in various aspects of spine surgery and can be a useful tool for spine surgeons...
April 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/29705104/low-temperature-fused-deposition-modeling-fdm-3d-printing-of-thermolabile-drugs
#9
Gayathri Kollamaram, Denise M Croker, Gavin M Walker, Alvaro Goyanes, Abdul W Basit, Simon Gaisford
Fused deposition modelling (FDM) is the most commonly investigated 3D printing technology for the manufacture of personalized medicines, however, high temperatures associated with the process limit its wider application. The objective of this study was to print low-melting and thermolabile drugs by reducing the FDM printing temperature. Two immediate release polymers, Kollidon VA64 and Kollidon 12PF were investigated as potential candidates for low-temperature FDM printing. Ramipril was used as the model low melting temperature drug (109°C); to the authors' knowledge this is the lowest melting point drug investigated to date by FDM printing...
April 26, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29692270/recent-advances-in-endocrine-metabolic-and-immune-disorders-mesenchymal-stem-cells-mscs-and-engineered-scaffolds
#10
Stefania Cantore, Vito Crincoli, Antonio Boccaccio, Antonio Emmanuele Uva, Michele Fiorentino, Giuseppe Monno, Patrizio Bollero, Chiara Derla, Francesca Fabiano, Andrea Ballini, Luigi Santacroce
BACKGROUND: New sources of stem cells in adult organisms are constantly emerging. Postnatal Mesenchymal Stem Cells (MSCs), are the most promising support to perform an effective regenerative medicine: such cells have the ability to differentiate into several lineages, such as osteoblasts and chondroblasts, providing novel strategies to improve different complex treatments, during bone regeneration. 3D-printed biomaterials can be designed with geometry aimed to induce stem cells to differentiate towards specific lineage...
April 22, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29678613/a-3d-printed-bilayer-oral-solid-dosage-form-combining-metformin-for-prolonged-and-glimepiride-for-immediate-drug-delivery
#11
Christos I Gioumouxouzis, Apostolos Baklavaridis, Orestis L Katsamenis, Catherine K Markopoulou, Nikolaos Bouropoulos, Dimitrios Tzetzis, Dimitrios G Fatouros
Fused Deposition Modelling (a.k.a. FDM-3D printing) has been previously employed in the development of personalized medicines with unique properties and release behavior. In the present work, a bilayer dosage form containing two anti-diabetic drugs with different daily dosage regimens; i.e. metformin and glimepiride, was manufactured via FDM 3D printing, studied using a variety of techniques and characterized in vitro. Metformin and glimepiride were embedded in Eudragit® RL sustained release layer and polyvinyl alcohol (PVA) layer respectively...
April 17, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29663706/patient-specific-bioinks-for-3d-bioprinting-of-tissue-engineering-scaffolds
#12
Negar Faramarzi, Iman K Yazdi, Mahboubeh Nabavinia, Andrea Gemma, Adele Fanelli, Andrea Caizzone, Leon M Ptaszek, Indranil Sinha, Ali Khademhosseini, Jeremy N Ruskin, Ali Tamayol
Bioprinting has emerged as a promising tool in tissue engineering and regenerative medicine. Various 3D printing strategies have been developed to enable bioprinting of various biopolymers and hydrogels. However, the incorporation of biological factors has not been well explored. As the importance of personalized medicine is becoming more clear, the need for the development of bioinks containing autologous/patient-specific biological factors for tissue engineering applications becomes more evident. Platelet-rich plasma (PRP) is used as a patient-specific source of autologous growth factors that can be easily incorporated to hydrogels and printed into 3D constructs...
April 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29652594/tissue-engineering-and-regenerative-medicine-2017-a-year-in-review
#13
Kyung Min Park, Young Min Shin, Kyobum Kim, Heungsoo Shin
In 2017, a new paradigm change caused by artificial intelligence and big data analysis resulted in innovation in each field of science and technology, and also significantly influenced progress in tissue engineering and regenerative medicine (TERM). TERM has continued to make technological advances based on interdisciplinary approaches and has contributed to the overall field of biomedical technology including cancer biology, personalized medicine, development biology, and cell-based therapeutics. While researchers are aware that there is still a long way to go until TERM reaches the ultimate goal of patient treatment through clinical translation, the rapid progress in convergence studies led by technological improvements in TERM has been encouraging...
March 13, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29642573/3d-printing-of-thermo-responsive-methylcellulose-hydrogels-for-cell-sheet-engineering
#14
Andrea Cochis, Lorenzo Bonetti, Rita Sorrentino, Nicola Contessi Negrini, Federico Grassi, Massimiliano Leigheb, Lia Rimondini, Silvia Farè
A possible strategy in regenerative medicine is cell-sheet engineering (CSE), i.e., developing smart cell culture surfaces from which to obtain intact cell sheets (CS). The main goal of this study was to develop 3D printing via extrusion-based bioprinting of methylcellulose (MC)-based hydrogels. Hydrogels were prepared by mixing MC powder in saline solutions (Na₂SO₄ and PBS). MC-based hydrogels were analyzed to investigate the rheological behavior and thus optimize the printing process parameters. Cells were tested in vitro on ring-shaped printed hydrogels; bulk MC hydrogels were used for comparison...
April 10, 2018: Materials
https://www.readbyqxmd.com/read/29619525/principles-of-three-dimensional-printing-and-clinical-applications-within-the-abdomen-and-pelvis
#15
REVIEW
Sarah Bastawrous, Nicole Wake, Dmitry Levin, Beth Ripley
Improvements in technology and reduction in costs have led to widespread interest in three-dimensional (3D) printing. 3D-printed anatomical models contribute to personalized medicine, surgical planning, and education across medical specialties, and these models are rapidly changing the landscape of clinical practice. A physical object that can be held in one's hands allows for significant advantages over standard two-dimensional (2D) or even 3D computer-based virtual models. Radiologists have the potential to play a significant role as consultants and educators across all specialties by providing 3D-printed models that enhance clinical care...
April 4, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29619449/3d-nanofabrication-inside-rapid-prototyped-microfluidic-channels-showcased-by-wet-spinning-of-single-micrometre-fibres
#16
Jonas Lölsberg, John Linkhorst, Arne Cinar, Alexander Jans, Alexander J C Kuehne, Matthias Wessling
Microfluidics is an established multidisciplinary research domain with widespread applications in the fields of medicine, biotechnology and engineering. Conventional production methods of microfluidic chips have been limited to planar structures, preventing the exploitation of truly three-dimensional architectures for applications such as multi-phase droplet preparation or wet-phase fibre spinning. Here the challenge of nanofabrication inside a microfluidic chip is tackled for the showcase of a spider-inspired spinneret...
April 5, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29608960/update-on-the-main-use-of-biomaterials-and-techniques-associated-with-tissue-engineering
#17
REVIEW
Daniela Steffens, Daikelly I Braghirolli, Natasha Maurmann, Patricia Pranke
Regenerative medicine involves the study of cells, signaling cues and biomatrices to restore normal function of tissues and organs. To develop the matrices for use in tissue engineering there are three main groups of biomaterials: (i) naturally derived materials; (ii) synthetic polymers; and (iii) decellularized organ or tissue scaffolds. These biomaterials, in various forms such as hydrogels, nanofibers and 3D scaffolds, among others, have been employed for different tissue regeneration purposes, with several techniques involved in their production, including rapid prototyping, tissue decellularization and electrospinning...
March 30, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29605693/defined-drug-release-from-3d-printed-composite-tablets-consisting-of-drug-loaded-polyvinylalcohol-and-a-water-soluble-or-water-insoluble-polymer-filler
#18
Tatsuaki Tagami, Noriko Nagata, Naomi Hayashi, Emi Ogawa, Kaori Fukushige, Norihito Sakai, Tetsuya Ozeki
3D-printed tablets are a promising new approach for personalized medicine. In this study, we fabricated composite tablets consisting of two components, a drug and a filler, by using a fused deposition modeling-type 3D printer. Polyvinylalcohol (PVA) polymer containing calcein (a model drug) was used as the drug component and PVA or polylactic acid (PLA) polymer without drug was used as the water-soluble or water-insoluble filler, respectively. Various kinds of drug-PVA/PVA and drug-PVA/PLA composite tablets were designed, and the 3D-printed tablets exhibited good formability...
March 29, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29601985/mechanical-characterization-and-numerical-simulation-of-a-subcutaneous-implantable-3d-printed-cell-encapsulation-system
#19
Federica Adamo, Marco Farina, Usha R Thekkedath, Alessandro Grattoni, Raffaella Sesana
Cell transplantation in bioengineered scaffolds and encapsulation systems has shown great promise in regenerative medicine. Depending on the site of implantation, type of cells and their expected function, these systems are designed to provide cells with a physiological-like environment while providing mechanical support and promoting long-term viability and function of the graft. A minimally invasive 3D printed system termed neovascularized implantable cell homing and encapsulation (NICHE) was developed in polylactic acid for subcutaneous transplantation of endocrine cells, including pancreatic islets...
March 21, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29601901/3d-printing-porosity-a-new-approach-to-creating-elevated-porosity-materials-and-structures
#20
A E Jakus, N R Geisendorfer, P L Lewis, R N Shah
We introduce a new process that enables the ability to 3D-print high porosity materials and structures by combining the newly introduced 3D-Painting process with traditional salt-leaching. The synthesis and resulting properties of three 3D-printable inks comprised of varying volume ratios (25:75, 50:50, 70:30) of CuSO4 salt and polylactide-co-glycolide (PLGA), as well as their as-printed and salt-leached counterparts, are discussed. The resulting materials are comprised entirely of PLGA (F-PLGA), but exhibit porosities proportional to the original CuSO4 content...
March 27, 2018: Acta Biomaterialia
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