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https://www.readbyqxmd.com/read/28641170/efficacy-and-safety-of-eslicarbazepine-acetate-monotherapy-for-partial-onset-seizures-experience-from-a-multicenter-observational-study
#1
Rafael Toledano, Camilo Espinosa Jovel, Adolfo Jiménez-Huete, Pau Giner Bayarri, Dulce Campos, Elena López Gomariz, Beatriz González Giráldez, Irene García-Morales, Mercé Falip, Paula Martínez Agredano, Susana Palao, María José Aguilar Amat Prior, María Rosa Querol Pascual, Francisco José Navacerrada, Francisco Javier López González, Joaquín Ojeda, Aránzazu Alfaro Sáez, Pedro Emilio Bermejo, Antonio Gil-Nagel
Eslicarbazepine acetate (ESL, Aptiom™) is a once-daily anticonvulsant, approved as adjunctive treatment of partial-onset seizures (POS). Historical-controlled trials investigating the use of ESL as monotherapy have demonstrated a favorable efficacy and tolerability profile in patients with POS. This prospective, non-interventional study recruited POS patients in 17 hospitals in Spain. After a 3-month baseline period, ESL therapy was initiated as 400mg QD and up-titrated to an optimal maintenance dose based on clinical response and tolerance...
June 19, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28634183/syk-inhibitors-interfere-with-erythrocyte-membrane-modification-during-p-falciparum-growth-and-suppress-parasite-egress
#2
Antonella Pantaleo, Kristina R Kesely, Maria Carmina Pau, Ioannis Tsamesidis, Evelin Schwarzer, Oleksii A Skorokhod, Huynh D Chien, Marta Ponzi, Lucia Bertuccini, Philip S Low, Francesco M Turrini
Band 3 (a.k.a. the anion exchanger, SLCA1, AE1) constitutes the major attachment site of the spectrin-based cytoskeleton to the erythrocyte's lipid bilayer and thereby contributes critically to the stability of the red cell membrane. During the intra-erythrocytic stage of Plasmodium falciparum's life cycle, band 3 becomes tyrosine phosphorylated in response to oxidative stress, leading to a decrease in its affinity for the spectrin/actin cytoskeleton and causing global membrane destabilization. Because this membrane weakening is hypothesized to facilitate parasite egress and the consequent dissemination of released merozoites throughout the bloodstream, we decided to explore which tyrosine kinase inhibitors might block the kinase-induced membrane destabilization...
June 20, 2017: Blood
https://www.readbyqxmd.com/read/28633312/the-influence-of-dekkera-bruxellensis-on-the-transcriptome-of-saccharomyces-cerevisiae-and-on-the-aromatic-profile-of-synthetic-wine-must
#3
Janez Kosel, Neža Cadež, Dorit Schuller, Laura Carreto, Ricardo Franco-Duarte, Peter Raspor
A double compartment membrane system was constructed in order to systematically study possible microbial interactions between yeasts Saccharomyces cerevisiae and Dekkera bruxellensis and their impact on wine aroma. The presence of D. bruxellensis induced 77 transcripts of S. cerevisiae. These were mostly of unknown function; however, some were involved in thiamine biosynthesis and in amino acid and polyamine transport, suggesting a competitive relationship between the two yeast species. Among the transcripts with no biological function, 14 of them were found to be the members of the PAU gene family that is associated with response to anaerobiosis stress...
June 1, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/28633067/microbial-electrosynthesis-of-butyrate-from-carbon-dioxide-production-and-extraction
#4
Pau Batlle-Vilanova, Ramon Ganigué, Sara Ramió-Pujol, Lluís Bañeras, Gerard Jiménez, Manuela Hidalgo, M Dolors Balaguer, Jesús Colprim, Sebastià Puig
To date acetate is the main product of microbial electrosynthesis (MES) from carbon dioxide (CO2). In this work a tubular bioelectrochemical system was used to carry out MES and enhance butyrate production over the other organic products. Batch tests were performed at a fixed cathode potential of -0.8V vs SHE. The reproducibility of the results according to previous experiments was validated in a preliminary test. According to the literature butyrate production could take place by chain elongation reactions at low pH and high hydrogen partial pressure (pH2)...
June 15, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28632739/validity-of-a-minimally-invasive-autopsy-tool-for-cause-of-death-determination-in-pediatric-deaths-in-mozambique-an-observational-study
#5
Quique Bassat, Paola Castillo, Miguel J Martínez, Dercio Jordao, Lucilia Lovane, Juan Carlos Hurtado, Tacilta Nhampossa, Paula Santos Ritchie, Sónia Bandeira, Calvino Sambo, Valeria Chicamba, Mamudo R Ismail, Carla Carrilho, Cesaltina Lorenzoni, Fabiola Fernandes, Pau Cisteró, Alfredo Mayor, Anelsio Cossa, Inacio Mandomando, Mireia Navarro, Isaac Casas, Jordi Vila, Khátia Munguambe, Maria Maixenchs, Ariadna Sanz, Llorenç Quintó, Eusebio Macete, Pedro Alonso, Clara Menéndez, Jaume Ordi
BACKGROUND: In recent decades, the world has witnessed unprecedented progress in child survival. However, our knowledge of what is killing nearly 6 million children annually in low- and middle-income countries remains poor, partly because of the inadequacy and reduced precision of the methods currently utilized in these settings to investigate causes of death (CoDs). The study objective was to validate the use of a minimally invasive autopsy (MIA) approach as an adequate and more acceptable substitute for the complete diagnostic autopsy (CDA) for pediatric CoD investigation in a poor setting...
June 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28628673/multiple-tolerance-defects-contribute-to-the-breach-of-b-cell-tolerance-in-new-zealand-black-chromosome-1-congenic-mice
#6
Nan-Hua Chang, Kieran P Manion, Christina Loh, Evelyn Pau, Yuriy Baglaenko, Joan E Wither
Lupus is characterized by a loss of B cell tolerance leading to autoantibody production. In this study, we explored the mechanisms underlying this loss of tolerance using B6 congenic mice with an interval from New Zealand Black chromosome 1 (denoted c1(96-100)) sufficient for anti-nuclear antibody production. Transgenes for soluble hen egg white lysozyme (sHEL) and anti-HEL immunoglobulin were crossed onto this background and various tolerance mechanisms examined. We found that c1(96-100) mice produced increased levels of IgM and IgG anti-HEL antibodies compared to B6 mice and had higher proportions of germinal center B cells and long-lived plasma cells, suggesting a germinal center-dependent breach of B cell anergy...
2017: PloS One
https://www.readbyqxmd.com/read/28628275/ureido-based-design-of-tunable-ucst-type-self-oscillating-polymer
#7
Tsukuru Masuda, Naohiko Shimada, Taira Sasaki, Atsushi Maruyama, Aya Mizutani Akimoto, Ryo Yoshida
Herein, we designed an upper critical solution temperature (UCST)-type self-oscillating polymer that exhibited rhythmic soluble-insoluble changes induced by Belousov-Zhabotinsky (BZ) reaction. The target polymers were prepared by conjugating Ru(bpy)3, a catalyst for the BZ reaction, to ureido-containing poly(allylamine-co-allylurea) (PAU) copolymers. The Ru(bpy)3-conjugated PAUs exhibited UCST-type phase transition behavior, and the solubility of the polymer changed in response to the alternation in the valency of Ru(bpy)3...
June 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28628244/phosphorylated-neurofilament-heavy-chain-a-biomarker-of-survival-for-c9orf72-associated-amyotrophic-lateral-sclerosis
#8
Tania F Gendron, Lillian M Daughrity, Michael G Heckman, Nancy N Diehl, Joanne Wuu, Timothy M Miller, Pau Pastor, John Q Trojanowski, Murray Grossman, James D Berry, William T Hu, Antonia Ratti, Michael Benatar, Vincenzo Silani, Jonathan D Glass, Mary Kay Floeter, Andreas Jeromin, Kevin B Boylan, Leonard Petrucelli
As potential treatments for C9ORF72-associated amyotrophic lateral sclerosis (c9ALS) approach clinical trials, the identification of prognostic biomarkers for c9ALS becomes a priority. We show that levels of phosphorylated neurofilament heavy chain (pNFH) in cerebrospinal fluid (CSF) predict disease status and survival in c9ALS patients, and are largely stable over time. Moreover, c9ALS patients exhibit higher pNFH levels, more rapid disease progression, and shorter survival after disease onset than ALS patients without C9ORF72 expansions...
June 19, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28622550/effect-of-gels-containing-chlorhexidine-or-epigallocatechin-3-gallate-on-the-protein-composition-of-the-acquired-enamel-pellicle
#9
Cíntia Maria de Souza-E-Silva, Talita Mendes da Silva Ventura, Luiza de Pau, la Silva Cassiano, Aline de Lima Leite, Marília Afonso Rabelo Buzalaf
OBJECTIVE: This study evaluated changes in protein profile of the acquired enamel pellicle (AEP) formed in vivo, after application of gels containing chlorhexidine or EGCG and further challenge with citric acid. DESIGN: AEP was formed in 9 volunteers for 2h and then treated with one of the following gels: placebo, 400μM EGCG or 0.012% chlorhexidine. A thin layer of gel was applied and after 1min the excess was removed. One hour after gel application, the AEP was collected from the buccal surface (upper and lower jaw) of one of the sides with filter paper dipped in 3% citric acid...
June 3, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28617064/corticosteroid-injection-for-the-treatment-of-morton-s-neuroma-a-prospective-double-blinded-randomized-placebo-controlled-trial
#10
Xavier Lizano-Díez, Alberto Ginés-Cespedosa, Eduard Alentorn-Geli, Daniel Pérez-Prieto, Gemma González-Lucena, Carlo Gamba, Santiago de Zabala, Alberto Solano-López, Pau Rigol-Ramón
BACKGROUND: The effectiveness of corticosteroid injection for the treatment of Morton's neuroma is unclear. In addition, most of the studies related to it are case-control or retrospective case series. The purpose of this study was to compare the effectiveness between corticosteroid injection associated with local anesthetic and local anesthetic alone (placebo control group) for the treatment of Morton's neuroma. METHODS: Forty-one patients with a diagnosis of Morton's neuroma were randomized to receive 3 injections of either a corticosteroid plus a local anesthetic or a local anesthetic alone...
June 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28611743/identification-and-characterization-of-mycoplasma-feriruminatoris-sp-nov-strains-isolated-from-alpine-ibex-a-4th-species-in-the-mycoplasma-mycoides-cluster-hosted-by-non-domesticated-ruminants
#11
Chloé Ambroset, Corinne Pau-Roblot, Yvette Game, Patrice Gaurivaud, Florence Tardy
The genus Mycoplasma, a group of free-living, wall-less prokaryotes includes more than 100 species of which dozens are primary pathogens of humans and domesticated animals. Mycoplasma species isolated from wildlife are rarely investigated but could provide a fuller picture of the evolutionary history and diversity of this genus. In 2013 several isolates from wild Caprinae were tentatively assigned to a new species, Mycoplasma (M.) feriruminatoris sp. nov., characterized by an unusually rapid growth in vitro and close genetic proximity to ruminant pathogenic species...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28602664/proteins-recovery-from-wet-microalgae-using-liquid-biphasic-flotation-lbf
#12
Win Nee Phong, Pau Loke Show, Wei Heng Teh, Tiong Xin Teh, Hilary Mae Yan Lim, Nurul Shafira Binti Nazri, Chung Hong Tan, Jo-Shu Chang, Tau Chuan Ling
In this work, the extraction of microalgal protein from wet Chlorella sorokiniana species using alcohol/salt liquid biphasic flotation (LBF) with the aid of ultrasonication for cell rupturing was proposed. The effect of varying crude feedstock concentration, flotation time, salt type, salt concentration, alcohol type, alcohol concentration, initial volumes of salt and alcohol were investigated. After the optimization process, the highest proportion of protein recovered in the top phase was achieved with 250g/L ammonium sulphate, 60% (v/v) 2-propanol, 1...
May 29, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28602394/reputational-concerns-with-altruistic-providers
#13
Pau Olivella, Luigi Siciliani
We study a model of reputational concerns when doctors differ in their degree of altruism and they can signal their altruism by their (observable) quality. When reputational concerns are high, following the introduction or enhancement of public reporting, the less altruistic (bad) doctor mimics the more altruistic (good) doctor. Otherwise, either a separating or a semi-separating equilibrium arises: the bad doctor mimics the good doctor with probability less than one. Pay-for-performance incentive schemes are unlikely to induce crowding out, unless some dimensions of quality are unobservable...
June 1, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/28600233/effect-of-tissue-heterogeneity-on-the-transmembrane-potential-of-type-1-spiral-ganglion-neurons-a-simulation-study
#14
Kiran Sriperumbudur, Hans Wilhelm Pau, Ursula van Rienen
Electric stimulation of the auditory nerve by cochlear implants has been a successful clinical intervention to treat the sensory neural deafness. In this pathological condition of the cochlea, type-1 spiral ganglion neurons in Rosenthal's canal play a vital role in the action potential initiation. Various morphological studies of the human temporal bones suggest that the spiral ganglion neurons are surrounded by heterogeneous structures formed by a variety of cells and tissues. However, the existing simulation models have not considered the tissue heterogeneity in the Rosenthal's canal while studying the electric field interaction with spiral ganglion neurons...
June 5, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28597167/predictors-of-thrombohemorrhagic-early-death-in-children-and-adolescents-with-t-15-17-positive-acute-promyelocytic-leukemia-treated-with-atra-and-chemotherapy
#15
Oussama Abla, Raul C Ribeiro, Anna Maria Testi, Pau Montesinos, Ursula Creutzig, Lillian Sung, Giancarlo Di Giuseppe, Derek Stephens, James H Feusner, Bayard L Powell, Henrik Hasle, Gertjan J L Kaspers, Luciano Dalla-Pozza, Alvaro Lassaletta, Martin S Tallman, Franco Locatelli, Dirk Reinhardt, Francesco Lo-Coco, Johann Hitzler, Miguel A Sanz
Clinical trials on childhood acute promyelocytic leukemia (APL) report early death (ED) rates of 3-8%, but predictors of thrombohemorrhagic (TH)-ED are not well understood. In a retrospective study, we aimed to determine the incidence and predictors of TH-ED in childhood APL. Data were analyzed from children and adolescents with t(15;17)-positive APL (n = 683) who started treatment with all-trans retinoic acid (ATRA) and chemotherapy in different international studies. Demographic data; initial white blood cell (WBC), peripheral blood (PB) blast, and platelet counts; hemoglobin value; coagulation parameters; morphologic variant (M3 or M3v); and induction details were analyzed...
June 8, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28595129/noisy-eeg-signals-classification-based-on-entropy-metrics-performance-assessment-using-first-and-second-generation-statistics
#16
REVIEW
David Cuesta-Frau, Pau Miró-Martínez, Jorge Jordán Núñez, Sandra Oltra-Crespo, Antonio Molina Picó
This paper evaluates the performance of first generation entropy metrics, featured by the well known and widely used Approximate Entropy (ApEn) and Sample Entropy (SampEn) metrics, and what can be considered an evolution from these, Fuzzy Entropy (FuzzyEn), in the Electroencephalogram (EEG) signal classification context. The study uses the commonest artifacts found in real EEGs, such as white noise, and muscular, cardiac, and ocular artifacts. Using two different sets of publicly available EEG records, and a realistic range of amplitudes for interfering artifacts, this work optimises and assesses the robustness of these metrics against artifacts in class segmentation terms probability...
May 31, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28594999/regenerating-bone-via-multifunctional-coatings-the-blending-of-cell-integration-and-bacterial-inhibition-properties-on-the-surface-of-biomaterials
#17
Mireia Hoyos-Nogués, Ferran Velasco, Maria-Pau Ginebra, José María Manero, F Javier Gil, Carlos Mas-Moruno
In dentistry and orthopedics, it is well accepted that implant fixation is a major goal. However, an emerging concern is bacterial infection. Infection of metallic implants can be catastrophic and significantly reduce patient quality of life. Accordingly, in this work, we focus on multifunctional coatings to simultaneously address and mitigate both these problems. We have developed a tailor-made peptide-based chemical platform that integrates the well-known RGD cell adhesive sequence and the lactoferrin-derived LF1-11 antimicrobial peptide...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28591639/mitochondrial-dynamics-mediated-by-mitofusin-1-is-required-for-pomc-neuron-glucose-sensing-and-insulin-release-control
#18
Sara Ramírez, Alicia G Gómez-Valadés, Marc Schneeberger, Luis Varela, Roberta Haddad-Tóvolli, Jordi Altirriba, Eduard Noguera, Anne Drougard, Álvaro Flores-Martínez, Mónica Imbernón, Iñigo Chivite, Macarena Pozo, Andrés Vidal-Itriago, Ainhoa Garcia, Sara Cervantes, Rosa Gasa, Ruben Nogueiras, Pau Gama-Pérez, Pablo M Garcia-Roves, David A Cano, Claude Knauf, Joan-Marc Servitja, Tamas L Horvath, Ramon Gomis, Antonio Zorzano, Marc Claret
Proopiomelanocortin (POMC) neurons are critical sensors of nutrient availability implicated in energy balance and glucose metabolism control. However, the precise mechanisms underlying nutrient sensing in POMC neurons remain incompletely understood. We show that mitochondrial dynamics mediated by Mitofusin 1 (MFN1) in POMC neurons couple nutrient sensing with systemic glucose metabolism. Mice lacking MFN1 in POMC neurons exhibited defective mitochondrial architecture remodeling and attenuated hypothalamic gene expression programs during the fast-to-fed transition...
June 6, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28586336/erratum-pim1-kinase-regulates-cell-death-tumor-growth-and-chemotherapy-response-in-triple-negative-breast-cancer
#19
Fara Brasó-Maristany, Simone Filosto, Steven Catchpole, Rebecca Marlow, Jelmar Quist, Erika Francesch-Domenech, Darren A Plumb, Leila Zakka, Patrycja Gazinska, Gianmaria Liccardi, Pascal Meier, Albert Gris-Oliver, Maggie Chon U Cheang, Anna Perdrix-Rosell, Manar Shafat, Elodie Noël, Nirmesh Patel, Kristen McEachern, Maurizio Scaltriti, Pau Castel, Farzana Noor, Richard Buus, Sumi Mathew, Johnathan Watkins, Violeta Serra, Pierfrancesco Marra, Anita Grigoriadis, Andrew N Tutt
No abstract text is available yet for this article.
June 6, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28583122/decision-making-experiences-of-family-members-of-older-adults-with-moderate-dementia-towards-community-and-residential-care-home-services-a-grounded-theory-study-protocol
#20
Lisa Pau Le Low, Lai Wah Lam, Kim Pong Fan
BACKGROUND: Caring and supporting older people with dementia have become a major public health priority. Recent reports have also revealed a diminishing number of family carers to provide dementia care in the future. Carers who are engaged in the caring role are known to bear significant psychological, practical and economic challenges as the disease advances over time. Seemingly, evidence indicates that the burden of care can be relieved by formal services. This study aims to explore decision-making experiences of family members of older adults with moderate dementia towards the use of community support (CS) and residential care home (RCH) services...
June 5, 2017: BMC Geriatrics
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