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https://www.readbyqxmd.com/read/28207895/the-metastasis-suppressor-kiss1-is-an-intrinsically-disordered-protein-slightly-more-extended-than-a-random-coil
#1
Alain Ibáñez de Opakua, Nekane Merino, Maider Villate, Tiago N Cordeiro, Georgina Ormaza, Marta Sánchez-Carbayo, Tammo Diercks, Pau Bernadó, Francisco J Blanco
The metastasis suppressor KISS1 is reported to be involved in the progression of several solid neoplasias, making it a promising molecular target for controlling their metastasis. The KISS1 sequence contains an N-terminal secretion signal and several dibasic sequences that are proposed to be the proteolytic cleavage sites. We present the first structural characterization of KISS1 by circular dichroism, multi-angle light scattering, small angle X-Ray scattering and NMR spectroscopy. An analysis of the KISS1 backbone NMR chemical shifts does not reveal any preferential conformation and deviation from a random coil ensemble...
2017: PloS One
https://www.readbyqxmd.com/read/28207407/deep-pain-exploiting-long-short-term-memory-networks-for-facial-expression-classification
#2
Pau Rodriguez, Guillem Cucurull, Jordi Gonalez, Josep M Gonfaus, Kamal Nasrollahi, Thomas B Moeslund, F Xavier Roca
Pain is an unpleasant feeling that has been shown to be an important factor for the recovery of patients. Since this is costly in human resources and difficult to do objectively, there is the need for automatic systems to measure it. In this paper, contrary to current state-of-the-art techniques in pain assessment, which are based on facial features only, we suggest that the performance can be enhanced by feeding the raw frames to deep learning models, outperforming the latest state-of-the-art results while also directly facing the problem of imbalanced data...
February 9, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28196069/correction-pedigree-and-snp-associated-genetics-and-recent-environment-are-the-major-contributors-to-anthropometric-and-cardiometabolic-trait-variation
#3
Charley Xia, Carmen Amador, Jennifer Huffman, Holly Trochet, Archie Campbell, David Porteous, Generation Scotland, Nicholas D Hastie, Caroline Hayward, Veronique Vitart, Pau Navarro, Chris S Haley
[This corrects the article DOI: 10.1371/journal.pgen.1005804.].
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28180305/disentangling-polydispersity-in-the-pcna-p15paf-complex-a-disordered-transient-and-multivalent-macromolecular-assembly
#4
Tiago N Cordeiro, Po-Chia Chen, Alfredo De Biasio, Nathalie Sibille, Francisco J Blanco, Jochen S Hub, Ramon Crehuet, Pau Bernadó
No abstract text is available yet for this article.
February 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28180267/private-troubles-to-public-issue-empowering-communities-to-reduce-alcohol-related-harm-in-sabah-malaysia
#5
Helen Benedict Lasimbang, Wendy Shoesmith, Mohd Nazri Bin Mohd Daud, Nirmal Kaur, Margaret Chin Pau Jin, Jaswant Singh, Wilfred John, Edna Salumbi, Lidwina Amir
No abstract text is available yet for this article.
February 1, 2017: Health Promotion International
https://www.readbyqxmd.com/read/28179271/childhood-cancer-type-1-diabetes-and-other-immune-diseases-healthcare-visits-in-the-year-before-diagnosis-in-taiwan
#6
TienYu Owen Yang, Wan-Ting Huang, Mei-Huei Chen, Kuan-Ying Arthur Huang, Pau-Chung Chen
BACKGROUND: Children with cancer, type 1 diabetes and other immune diseases often present initially with non-specific problems. It is unknown how long children with these conditions seek medical help before a diagnosis is reached. METHODS: During the period 2002 to 2013, 7238 children aged 2-15 years diagnosed with cancer at seven sites, type 1 diabetes, and three other immune diseases were registered in the Taiwan National Health Insurance Catastrophic Illness Database...
February 8, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28177843/estimation-of-long-terminal-repeat-element-content-in-the-i-helicoverpa-zea-i-genome-from-high-throughput-sequencing-of-bacterial-artificial-chromosome-bac-pools
#7
Brad Coates, Craig A Abel, Omaththage P Perera
The lepidopteran pest insect <i>Helicoverpa zea</i> feeds on cultivated corn and cotton across the Americas where control remains challenging due to evolution of resistance to chemical and transgenic insecticidal toxins, yet genomic resources remain scarce for this species. A bacterial artificial chromosome (BAC) library having a mean genomic insert size of 145±20 kb was created from a laboratory strain of <i>H. zea</i>, which provides ~12.9-fold coverage of a 362.8±8.8 Mb (0.37±0...
November 15, 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28177011/mononuclear-ruthenium-compounds-bearing-n-donor-and-n-heterocyclic-carbene-ligands-structure-and-oxidative-catalysis
#8
Hai-Jie Liu, Marcos Gil-Sepulcre, Laia Francàs, Pau Nolis, Teodor Parella, Jordi Benet-Buchholz, Xavier Fontrodona, Jordi García-Antón, Nuria Romero, Antoni Llobet, Lluís Escriche, Roger Bofill, Xavier Sala
A new CNNC carbene-phthalazine tetradentate ligand has been synthesised, which in the reaction with [Ru(T)Cl3] (T = trpy, tpm, bpea; trpy = 2,2';6',2''-terpyridine; tpm = tris(pyrazol-1-yl)methane; bpea = N,N-bis(pyridin-2-ylmethyl)ethanamine) in MeOH or iPrOH undergoes a C-N bond scission due to the nucleophilic attack of a solvent molecule, with the subsequent formation of the mononuclear complexes cis-[Ru(PhthaPz-OR)(trpy)X](n+), [Ru(PhthaPz-OMe)(tpm)X](n+) and trans,fac-[Ru(PhthaPz-OMe)(bpea)X](n+) (X = Cl, n = 1; X = H2O, n = 2; PhthaPz-OR = 1-(4-alkoxyphthalazin-1-yl)-3-methyl-1H-imidazol-3-ium), named 1a(+)/2a(2+) (R = Me), 1b(+)/2b(2+) (R = iPr), 3(+)/4(2+) and 5(+)/6(2+), respectively...
February 8, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28168445/regulation-of-the-h-atp-synthase-by-if1-a-role-in-mitohormesis
#9
REVIEW
Pau B Esparza-Moltó, Cristina Nuevo-Tapioles, José M Cuezva
The mitochondrial H(+)-ATP synthase is a primary hub of cellular homeostasis by providing the energy required to sustain cellular activity and regulating the production of signaling molecules that reprogram nuclear activity needed for adaption to changing cues. Herein, we summarize findings regarding the regulation of the activity of the H(+)-ATP synthase by its physiological inhibitor, the ATPase inhibitory factor 1 (IF1) and their functional role in cellular homeostasis. First, we outline the structure and the main molecular mechanisms that regulate the activity of the enzyme...
February 6, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28161887/evaluation-of-vitamin-and-trace-element-requirements-after-sleeve-gastrectomy-at-long-term
#10
Silvia Pellitero, Eva Martínez, Rocío Puig, Alba Leis, Roxanna Zavala, María Luisa Granada, Cruz Pastor, Pau Moreno, Jordi Tarascó, Manel Puig-Domingo
BACKGROUND: Nutritional deficiencies are common after bariatric surgery, but data are scarce after sleeve gastrectomy (SG) at long term. METHODS: We performed a prospective nutritional status evaluation before and at 2 and 5 years after SG in morbid obese patients receiving mulvitamin and mineral supplementation at a Spanish university hospital. One hundred seventy-six patients (49.3 ± 9.1 years and 46.7 ± 7.4 kg/m(2)) were evaluated; 51 of them were followed during 5 years...
February 4, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28159836/c-myc-downregulation-is-required-for-preacinar-to-acinar-maturation-and-pancreatic-homeostasis
#11
Victor J Sánchez-Arévalo Lobo, Luis César Fernández, Enrique Carrillo-de-Santa-Pau, Laia Richart, Isidoro Cobo, Jaroslaw Cendrowski, Ulisses Moreno, Natalia Del Pozo, Diego Megías, Bernardette Bréant, Christopher V Wright, Mark Magnuson, Francisco X Real
BACKGROUND AND AIMS: c-Myc is highly expressed in pancreatic multipotent progenitor cells (MPC) and in pancreatic cancer. The transition from MPC to unipotent acinar progenitors is associated with c-Myc downregulation; a role for c-Myc in this process, and its possible relationship to a role in cancer, has not been established. DESIGN: Using coimmunoprecipitation assays, we demonstrate that c-Myc and Ptf1a interact. Using reverse transcriptase qPCR, western blot and immunofluorescence, we show the erosion of the acinar programme...
February 3, 2017: Gut
https://www.readbyqxmd.com/read/28158206/statin-improves-survival-in-patients-with-egfr-tki-lung-cancer-a-nationwide-population-based-study
#12
Ming-Szu Hung, I-Chuan Chen, Chuan-Pin Lee, Ru-Jiun Huang, Pau-Chung Chen, Ying-Huang Tsai, Yao-Hsu Yang
Long-term use of statins has been reported to reduce the risk of death in patients with lung cancer. This study investigated the effect of statin use among patients with lung cancer receiving epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKIs) therapy. A nationwide, population-based case-control study was conducted using the Taiwan National Health Insurance Research Database. From January 1, 1997 to December 31, 2012, a total of 1,707 statin and 6,828 non-statin matched lung cancer cohorts with EGFR-TKIs treatment were studied...
2017: PloS One
https://www.readbyqxmd.com/read/28153336/genome-wide-regional-heritability-mapping-identifies-a-locus-within-the-tox2-gene-associated-with-major-depressive-disorder
#13
Yanni Zeng, Pau Navarro, Masoud Shirali, David M Howard, Mark J Adams, Lynsey S Hall, Toni-Kim Clarke, Pippa A Thomson, Blair H Smith, Alison Murray, Sandosh Padmanabhan, Caroline Hayward, Thibaud Boutin, Donald J MacIntyre, Cathryn M Lewis, Naomi R Wray, Divya Mehta, Brenda W J H Penninx, Yuri Milaneschi, Bernhard T Baune, Tracy Air, Jouke-Jan Hottenga, Hamdi Mbarek, Enrique Castelao, Giorgio Pistis, Thomas G Schulze, Fabian Streit, Andreas J Forstner, Enda M Byrne, Nicholas G Martin, Gerome Breen, Bertram Müller-Myhsok, Susanne Lucae, Stefan Kloiber, Enrico Domenici, Ian J Deary, David J Porteous, Chris S Haley, Andrew M McIntosh
BACKGROUND: Major depressive disorder (MDD) is the second largest cause of global disease burden. It has an estimated heritability of 37%, but published genome-wide association studies have so far identified few risk loci. Haplotype-block-based regional heritability mapping (HRHM) estimates the localized genetic variance explained by common variants within haplotype blocks, integrating the effects of multiple variants, and may be more powerful for identifying MDD-associated genomic regions...
December 16, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28149957/illuminating-phenylazopyridines-to-photoswitch-metabotropic-glutamate-receptors-from-the-flask-to-the-animals
#14
Xavier Gómez-Santacana, Silvia Pittolo, Xavier Rovira, Marc Lopez, Charleine Zussy, James A R Dalton, Adèle Faucherre, Chris Jopling, Jean-Philippe Pin, Francisco Ciruela, Cyril Goudet, Jesús Giraldo, Pau Gorostiza, Amadeu Llebaria
Phenylazopyridines are photoisomerizable compounds with high potential to control biological functions with light. We have obtained a series of phenylazopyridines with light dependent activity as negative allosteric modulators (NAM) of metabotropic glutamate receptor subtype 5 (mGlu5). Here we describe the factors needed to achieve an operational molecular photoisomerization and its effective translation into in vitro and in vivo receptor photoswitching, which includes zebrafish larva motility and the regulation of the antinociceptive effects in mice...
January 25, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28146055/effects-of-gender-on-the-association-of-urinary-phthalate-metabolites-with-thyroid-hormones-in-children-a-prospective-cohort-study-in-taiwan
#15
Te-I Weng, Mei-Huei Chen, Guang-Wen Lien, Pai-Shan Chen, Jasper Chia-Cheng Lin, Cheng-Chung Fang, Pau-Chung Chen
Phthalates are considered endocrine disruptors. Our study assessed the gender-specific effects of phthalate exposure on thyroid function in children. In total, 189 Taiwanese children were enrolled in the study. One-spot urine and blood samples were collected for analyzing 12 phthalate metabolites in urine and thyroid hormones. The association between urinary phthalate metabolites and serum thyroid hormones was determined using a generalized linear model with a log link function; the children were categorized into groups for analysis according to the 33rd and 66th percentiles...
January 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28145865/fluctuations-of-the-transcription-factor-atml1-generate-the-pattern-of-giant-cells-in-the-arabidopsis-sepal
#16
Heather M Meyer, José Teles, Pau Formosa-Jordan, Yassin Refahi, Rita San-Bento, Gwyneth Ingram, Henrik Jönsson, James Cw Locke, Adrienne Hk Roeder
Multicellular development produces patterns of specialized cell types. Yet, it is often unclear how individual cells within a field of identical cells initiate the patterning process. Using live imaging, quantitative image analyses and modeling, we show that during Arabidopsis thaliana sepal development, fluctuations in the concentration of the transcription factor ATML1 pattern a field of identical epidermal cells to differentiate into giant cells interspersed between smaller cells. We find that ATML1 is expressed in all epidermal cells...
February 1, 2017: ELife
https://www.readbyqxmd.com/read/28128096/validation-of-a-colistin-plasma-concentration-breakpoint-as-a-predictor-of-nephrotoxicity-in-patients-treated-with-colistin-methanesulfonate
#17
Juan P Horcajada, Luisa Sorlí, Sonia Luque, Natividad Benito, Concepción Segura, Nuria Campillo, Milagro Montero, Erika Esteve, Beatriz Mirelis, Virginia Pomar, Jordi Cuquet, Carmina Martí, Pau Garro, Santiago Grau
Nephrotoxicity limits the effective use of colistin for the treatment of multidrug-resistant Gram-negative bacteria (MDR-GNB) infections. We previously defined a steady-state colistin plasma concentration (Css) of 2.42 mg/L that predicted nephrotoxicity at end of treatment (EOT). The objective of this study was to validate this breakpoint in a prospective cohort. This was a multicentre, prospective, observational study conducted at three hospitals with a cohort of patients treated for MDR-GNB infection with colistin methanesulfonate from September 2011 until January 2015...
December 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28126036/genome-wide-analysis-of-differential-transcriptional-and-epigenetic-variability-across-human-immune-cell-types
#18
Simone Ecker, Lu Chen, Vera Pancaldi, Frederik O Bagger, José María Fernández, Enrique Carrillo de Santa Pau, David Juan, Alice L Mann, Stephen Watt, Francesco Paolo Casale, Nikos Sidiropoulos, Nicolas Rapin, Angelika Merkel, Hendrik G Stunnenberg, Oliver Stegle, Mattia Frontini, Kate Downes, Tomi Pastinen, Taco W Kuijpers, Daniel Rico, Alfonso Valencia, Stephan Beck, Nicole Soranzo, Dirk S Paul
BACKGROUND: A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and epigenetic variability. RESULTS: We apply a novel analytical approach to measure and compare transcriptional and epigenetic variability genome-wide across CD14(+)CD16(-) monocytes, CD66b(+)CD16(+) neutrophils, and CD4(+)CD45RA(+) naïve T cells from the same 125 healthy individuals. We discover substantially increased variability in neutrophils compared to monocytes and T cells...
January 26, 2017: Genome Biology
https://www.readbyqxmd.com/read/28120471/a-prospective-study-of-the-utility-of-plasma-biomarkers-to-diagnose-alcoholic-hepatitis
#19
Julien Bissonnette, José Altamirano, Cécile Devue, Olivier Roux, Audrey Payancé, Didier Lebrec, Pierre Bedossa, Dominique Valla, François Durand, Hafid Ait Oufella, Pau Sancho-Bru, Joan Caballeria, Pere Ginès, Chantal M Boulanger, Ramon Bataller, Pierre-Emmanuel Rautou
: The diagnosis of alcoholic hepatitis (AH) often requires a transjugular liver biopsy (TJLB), a procedure not always readily accessible. We analyzed plasma biomarkers to estimate the presence of histological features of AH among patients with clinical suspicion of AH. Using ELISA, we tested M65 and M30 (circulating fragments of cytokeratin-18) and their respective fraction carried by microvesicles (MVs), CCL20 and TREM1. Leukocyte, platelet and endothelial-derived MVs were quantified by flow cytometry...
January 24, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28118965/asparaginase-use-for-the-treatment-of-acute-lymphoblastic-leukemia
#20
Pere Barba, José Luis Dapena, Pau Montesinos, Susana Rives
No abstract text is available yet for this article.
January 21, 2017: Medicina Clínica
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