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https://www.readbyqxmd.com/read/29352712/evaluating-new-bio-hydrogen-producers-clostridium-perfringens-strain-jjc-clostridium-bifermentans-strain-wym-and-clostridium-sp-strain-ade-ty
#1
Yee Meng Wong, Ta Yeong Wu, Tau Chuan Ling, Pau Loke Show, Sze Ying Lee, Jo-Shu Chang, Shaliza Ibrahim, Joon Ching Juan
Three newly discovered H2 producing bacteria namely Clostridium perfringens strain JJC, Clostridium bifermentans strain WYM and Clostridium sp. strain Ade.TY originated from landfill leachate sludge have demonstrated highly efficient H2 production. The maximum H2 production attained from these isolates are in the descending order of strain C. perfringens strain JJC > C. bifermentans strain WYM > Clostridium sp. strain Ade.TY with yield of 4.68 ± 0.12, 3.29 ± 0.11, and 2.87 ± 0.10 mol H2/mol glucose, respectively...
January 15, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29346333/platelet-rich-plasma-new-insights-for-cutaneous-wound-healing-management
#2
REVIEW
Deborah Chicharro-Alcántara, Mónica Rubio-Zaragoza, Elena Damiá-Giménez, José M Carrillo-Poveda, Belén Cuervo-Serrato, Pau Peláez-Gorrea, Joaquín J Sopena-Juncosa
The overall increase of chronic degenerative diseases associated with ageing makes wound care a tremendous socioeconomic burden. Thus, there is a growing need to develop novel wound healing therapies to improve cutaneous wound healing. The use of regenerative therapies is becoming increasingly popular due to the low-invasive procedures needed to apply them. Platelet-rich plasma (PRP) is gaining interest due to its potential to stimulate and accelerate the wound healing process. The cytokines and growth factors forming PRP play a crucial role in the healing process...
January 18, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29343133/central-nervous-system-malformation-associated-with-methamphetamine-abuse-during-pregnancy
#3
Silvia Maya-Enero, Júlia Candel-Pau, Mónica Rebollo-Polo, Santiago Candela-Cantó, Rafael de la Torre, María Ángeles López-Vílchez
INTRODUCTION: Prenatal methamphetamine exposure is related to prematurity, fetal growth restriction, neurobehavioral effects and long-term motor and cognitive sequelae. PATIENT PRESENTATION: We report the case of a newborn from a Filipina with no prenatal care with a complex brain malformation. Methamphetamine was identified in maternal and neonatal urine and in maternal hair, raising our suspicion of methamphetamine as a cause of this malformation. DISCUSSION: Methamphetamine abuse is a growing problem worldwide...
January 17, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29342892/next-generation-wireless-technologies-for-internet-of-things
#4
EDITORIAL
Giovanni Pau, Claude Chaudet, Dixian Zhao, Mario Collotta
In the fast-growing Internet of Things (IoT)[...].
January 14, 2018: Sensors
https://www.readbyqxmd.com/read/29342187/induction-of-high-tolerance-to-artemisinin-by-sub-lethal-administration-a-new-in-vitro-model-of-p-falciparum
#5
Serena De Lucia, Ioannis Tsamesidis, Maria Carmina Pau, Kristina R Kesely, Antonella Pantaleo, Francesco Turrini
Artemisinin resistance is a major threat to malaria control efforts. Resistance is characterized by an increase in the Plasmodium falciparum parasite clearance half-life following treatment with artemisinin-based combination therapies (ACTs) and an increase in the percentage of surviving parasites. The remarkably short blood half-life of artemisinin derivatives may contribute to drug-resistance, possibly through factors including sub-lethal plasma concentrations and inadequate exposure. Here we selected for a new strain of artemisinin resistant parasites, termed the artemisinin resistant strain 1 (ARS1), by treating P...
2018: PloS One
https://www.readbyqxmd.com/read/29336481/the-unguarded-x-and-the-genetic-architecture-of-lifespan-inbreeding-results-in-a-potentially-maladaptive-sex-specific-reduction-of-female-lifespan-in-drosophila-melanogaster
#6
Zahida Sultanova, Muhammed Andic, Pau Carazo
Sex differences in ageing and lifespan are ubiquitous in nature. The "unguarded-X" hypothesis (UXh) suggests they may be partly due to the expression of recessive mutations in the hemizygous sex chromosomes of the heterogametic sex, which could help explain sex-specific ageing in a broad array of taxa. A prediction central to the UX hypothesis is that inbreeding will decrease the lifespan of the homogametic sex more than the heterogametic sex, because only in the former does inbreeding increase the expression of recessive deleterious mutations...
January 16, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29334105/specific-labeling-of-mitochondria-of-chlamydomonas-with-cationic-helicene-fluorophores
#7
Christoph Bauer, Romain Duwald, Geraldine Maria Labrador, Simon Pascal, Pau Moneva Lorente, Johann Bosson, Jérôme Lacour, Jean-David Rochaix
Twelve cationic helicenes and one triangulene were tested for the specific labeling of mitochondria from algal cells. Octyl ester derivative 5 readily penetrates algal cells and gives rise to clear fluorescence patterns when it is used at concentrations in the μM range. Under these conditions, cell structures are well preserved and cell survival is not compromised. Cationic helicene compounds such as 5 provide new useful tools for examining the mitochondrial network and its dynamics including fission and fusion events...
January 15, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29329345/survival-benefit-associated-with-metformin-use-in-inoperable-non-small-cell-lung-cancer-patients-with-diabetes-a-population-based-retrospective-cohort-study
#8
Min-Chun Chuang, Yao-Hsu Yang, Ying-Huang Tsai, Meng-Jer Hsieh, Yu-Ching Lin, Chin-Kuo Lin, Pau-Chung Chen, Tsung-Ming Yang
OBJECTIVE: To evaluate the effects of metformin use on the survival of inoperable non-small cell lung cancer (NSCLC) patients with diabetes using the Taiwanese National Health Insurance Research Database. RESEARCH DESIGN AND METHODS: In total, 7,620 patients were eligible in this study, among them, 3,578 patients were metformin users and 4,042 were non-users. Propensity score matching was used to reduce possible confounding factors. In total, 4,182 patients (2,091 matched pairs) were included in the matched cohort...
2018: PloS One
https://www.readbyqxmd.com/read/29327385/ultrathin-semiconductor-superabsorbers-from-the-visible-to-the-near-infrared
#9
Pau Molet, Juan Luis Garcia-Pomar, Cristiano Matricardi, Miquel Garriga, Maria Isabel Alonso, Agustín Mihi
The design of ultrathin semiconducting materials that achieve broadband absorption is a long-sought-after goal of crucial importance for optoelectronic applications. To date, attempts to tackle this problem consisted either of the use of strong-but narrowband-or broader-but moderate-light-trapping mechanisms. Here, a strategy that achieves broadband optimal absorption in arbitrarily thin semiconductor materials for all energies above their bandgap is presented. This stems from the strong interplay between Brewster modes, sustained by judiciously nanostructured thin semiconductors on metal films, and photonic crystal modes...
January 12, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29321673/genomic-analysis-of-family-data-reveals-additional-genetic-effects-on-intelligence-and-personality
#10
W David Hill, Ruben C Arslan, Charley Xia, Michelle Luciano, Carmen Amador, Pau Navarro, Caroline Hayward, Reka Nagy, David J Porteous, Andrew M McIntosh, Ian J Deary, Chris S Haley, Lars Penke
Pedigree-based analyses of intelligence have reported that genetic differences account for 50-80% of the phenotypic variation. For personality traits these effects are smaller, with 34-48% of the variance being explained by genetic differences. However, molecular genetic studies using unrelated individuals typically report a heritability estimate of around 30% for intelligence and between 0 and 15% for personality variables. Pedigree-based estimates and molecular genetic estimates may differ because current genotyping platforms are poor at tagging causal variants, variants with low minor allele frequency, copy number variants, and structural variants...
January 10, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29316249/the-mitochondrial-atp-synthase-is-a-shared-drug-target-for-aging-and-dementia
#11
Joshua Goldberg, Antonio Currais, Marguerite Prior, Wolfgang Fischer, Chandramouli Chiruta, Eric Ratliff, Daniel Daugherty, Richard Dargusch, Kim Finley, Pau B Esparza-Moltó, José M Cuezva, Pamela Maher, Michael Petrascheck, David Schubert
Aging is a major driving force underlying dementia, such as that caused by Alzheimer's disease (AD). While the idea of targeting aging as a therapeutic strategy is not new, it remains unclear how closely aging and age-associated diseases are coupled at the molecular level. Here, we discover a novel molecular link between aging and dementia through the identification of the molecular target for the AD drug candidate J147. J147 was developed using a series of phenotypic screening assays mimicking disease toxicities associated with the aging brain...
January 7, 2018: Aging Cell
https://www.readbyqxmd.com/read/29310554/primary-arterial-switch-operation-for-late-referral-of-transposition-of-the-great-arteries-with-intact-ventricular-septum-in-the-current-era-do-we-still-need-a-rapid-two-stage-operation
#12
Noritaka Ota, Sivakumar Sivalingam, Kiew Kong Pau, Chee Chin Hew, Jeswant Dillon, Haifa Abdul Latiff, Hasri Samion, Mohd Azhari Yakub
OBJECTIVE: We introduced primary arterial switch operation for the patient with transposition of great arteries and intact ventricular septum (TGA-IVS) who had more than 3.5 mm of posterior left ventricle (LV) wall thickness. METHODS: Between January 2013 and June 2015, a total of 116 patients underwent arterial switch operation. Of the 116 patients, 26 with TGA-IVS underwent primary arterial switch operation at more than 30 days of age. RESULTS: The age and body weight (mean ± SD) at the operation were 120...
January 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29307128/immature-ovarian-teratoma-in-two-heifers
#13
Augusto Carluccio, Maria Teresa Zedda, Alberto Contri, Alessia Gloria, Domenico Robbe, Ippolito De Amicis, Salvatore Pau
A 15 months-old Simmental heifer (SH) and a 18 months-old Marchigiana heifer (MH) were referred to the Faculty of Veterinary Medicine of Teramo (Italy). In the rst heifer, clinical examination of the vulva, vestibulum, and vagina showed no signs of disease and no discharge was detected. Palpation per rectum revealed a mass in the left portion of the abdominal cavity, closely attached to the tip of the left uterine horn. The mass was mainly rm and brous and its surface was slightly lobulated. The second heifer had a history of a regular cycle from the 11th to the 14th month of age followed by an anoestrus state...
December 29, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/29305104/heart-failure-with-mid-range-ejection-fraction-in-patients-admitted-to-internal-medicine-departments-findings-from-the-rica-registry
#14
María Esther Guisado-Espartero, Prado Salamanca-Bautista, Óscar Aramburu-Bodas, Alicia Conde-Martel, José Luis Arias-Jiménez, Pau Llàcer-Iborra, Melitón Francisco Dávila-Ramos, Yolanda Cabanes-Hernández, Luis Manzano, Manuel Montero-Pérez-Barquero
AIM: To improve the knowledge on characteristics, treatment and prognosis in patients with heart failure (HF) and mid-range ejection fraction discharged after an acute HF episode. METHODS: We prospectively included and followed 2753 patients admitted with HF to Internal Medicine units. Patients were classified according to ejection fraction (EF) into three strata: reduced, EF <40% (HFrEF); mid-range EF 40-49% (HFmrEF); and preserved EF ≥50% (HFpEF). Clinical, echocardiographic, laboratory data and treatment at discharge were recorded and the groups were compared...
January 2, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29291461/relationship-between-body-composition-and-postural-control-in-prepubertal-overweight-obese-children-a-cross-sectional-study
#15
Israel Villarrasa-Sapiña, Julio Álvarez-Pitti, Ruth Cabeza-Ruiz, Pau Redón, Empar Lurbe, Xavier García-Massó
BACKGROUND: Excess body weight during childhood causes reduced motor functionality and problems in postural control, a negative influence which has been reported in the literature. Nevertheless, no information regarding the effect of body composition on the postural control of overweight and obese children is available. The objective of this study was therefore to establish these relationships. METHODS: A cross-sectional design was used to establish relationships between body composition and postural control variables obtained in bipedal eyes-open and eyes-closed conditions in twenty-two children...
December 21, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29287669/a-multidisciplinary-approach-to-oncology-trials-study-conduct-of-the-anthalya-trial
#16
Youssef Ghazi, Christine Laurent, Julien Dupin, David Pau, Sabine Balouet, Yara Rocha, Florence Joly, Roman Rouzier, Violette Menguy
Clinical trials that combine medical therapy and surgical treatment pose a number of challenges. The ANTHALYA trial investigated the efficacy and safety of adding bevacizumab to neoadjuvant carboplatin-paclitaxel chemotherapy prior to interval debulking surgery (IDS) in patients with ovarian cancer. The success of the trial depended on the efficacy and the safety of the combination and on the surgical effort. Furthermore, at the time of study design, neoadjuvant bevacizumab had not been investigated in ovarian cancer patients and it was unknown if neoadjuvant angiogenic therapy would be well tolerated or would negatively impact the success of IDS...
December 26, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29287326/aroma-profile-design-of-wine-spirits-multi-objective-optimization-using-response-surface-methodology
#17
Pau Matias-Guiu, Juan José Rodríguez-Bencomo, José R Pérez-Correa, Francisco López
Developing new distillation strategies can help the spirits industry to improve quality, safety and process efficiency. Batch stills equipped with a packed column and an internal partial condenser are an innovative experimental system, allowing a fast and flexible management of the rectification. In this study, the impact of four factors (heart-cut volume, head-cut volume, pH and cooling flow rate of the internal partial condenser during the head-cut fraction) on 18 major volatile compounds of Muscat spirits was optimized using response surface methodology and desirability function approaches...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29287309/aspirin-dose-in-kawasaki-disease-the-ongoing-battle
#18
Anita Dhanrajani, Mercedes Chan, Stephanie Pau, Janet Ellsworth, Ross Petty, Jaime Guzman
BACKGROUND: Kawasaki disease (KD) is an acute childhood vasculitis that may result in coronary aneurysms. Treatment of Kawasaki disease (KD) with a single infusion of 2g/kg intravenous immunoglobulin (IVIG) is well established, but acetyl-salicylic acid (ASA) dose remains controversial. METHODS: We reviewed charts of patients with KD from two Canadian centres to assess the impact of ASA dose on IVIG resistance (operationally defined as administration of a second dose of IVIG)...
December 29, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29285980/xenon-protects-against-blast-induced-traumatic-brain-injury-in-an-i-in-vitro-i-model
#19
Rita Campos-Pires, Mariia Koziakova, Amina Yonis, Ashni Pau, Warren Macdonald, Katie Harris, Christopher Edge, Nicholas P Franks, Peter Mahoney, Robert Dickinson
The aim of this study was to evaluate the neuroprotective efficacy of the inert gas xenon as a treatment for blast-induced traumatic brain injury in an in vitro laboratory model. We developed a novel blast traumatic brain injury model using C57BL/6N mouse organotypic hippocampal brain-slice cultures exposed to a single shockwave, with the resulting injury quantified using propidium iodide fluorescence. A shock tube blast generator was used to simulate open field explosive blast shockwaves, modeled by the Friedlander waveform...
December 29, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29282362/genetic-variants-in-the-vegf-pathway-as-prognostic-factors-in-stages-ii-and-iii-colon-cancer
#20
Pau Riera, Anna C Virgili, Juliana Salazar, Ana Sebio, María Tobeña, Ivana Sullivan, David Páez
The role of vascular endothelial growth factor (VEGF) gene polymorphisms in the prognosis of colon cancer prognosis remains unclear. We evaluated the influence of 28 single-nucleotide polymorphisms in 12 genes in the VEGF pathway on the prognosis of 347 patients with stage II-III colon cancer. We found that rs9513070 (VEGFR1) and rs1137282 (KRAS) were associated with overall survival in stage II colon cancer patients (p = 0.025 and p = 0.001, respectively). When primary tumor location was considered, rs9513070 was also associated with relapse-free and overall survival (p = 0...
December 27, 2017: Pharmacogenomics Journal
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