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https://www.readbyqxmd.com/read/28807848/hydroalcoholic-extract-from-bark-of-persea-major-meisn-l-e-kopp-lauraceae-exerts-antiulcer-effects-in-rodents-by-the-strengthening-of-the-gastric-protective-factors
#1
Lincon Bordignon Somensi, Thaise Boeing, Benhur Judah Cury, Viviane Miranda Bispo Steimbach, Rivaldo Niero, Lauro Mera de Souza, Luisa Mota da Silva, Sérgio Faloni de Andrade
ETHOPHARMACOLOGICAL RELEVANCE: The Persea major (Meisn.) L.E. Kopp (Lauraceae) (botanical synonym: Persea pyrifolia (D. Don) Spreng, Persea pyrifolia Nees and Mart., Persea cordata var. major (Meisn.) Mez and Persea willdenovii Kosterm) is a medicinal plant native in the south of Brazil, where is popularly known as Pau de Andrade, Maçaranduba or Abacate-do-Mato. Its barks are commonly used to prepare an infusion which is administered orally or topically to treat ulcers and wounds, respectively...
August 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28807396/polycystic-ovary-morphology-age-based-ultrasound-criteria
#2
Hyun-Jun Kim, Judith M Adams, Jens A Gudmundsson, Gudmundur Arason, Cindy T Pau, Corrine K Welt
OBJECTIVE: To determine age-based criteria for polycystic ovary morphology. DESIGN: Cross-sectional, case-control design. SETTING: Outpatient setting. SUBJECT(S): Women with polycystic ovary syndrome (PCOS) defined by hyperandrogenism and irregular menses (n = 544) and controls with regular menses and no evidence of hyperandrogenism (n = 666) participated. Parameters were tested in a second cohort of women with PCOS (n = 105) and controls (n = 32) meeting the same criteria...
August 11, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28802428/changes-in-trunk-sway-of-quay-crane-operators-during-work-shift-a-possible-marker-for-fatigue
#3
Bruno Leban, Gianfranco Fancello, Paolo Fadda, Massimiliano Pau
This study investigated changes in task-induced trunk sway of quay crane operators during a four-hour shift performed in a dedicated simulator as an indicator of postural control system effectiveness. Using a pressure sensitive mat placed on the seat pan, center-of-pressure (COP) time series were acquired and processed to calculate sway area, path length and COP displacements and velocities. The results show a well-defined linear trend for sway path and area, with significant increases starting from 65 to 155 min of work respectively...
November 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28801080/reprint-of-anticancer-activity-of-hydroxy-and-sulfonamide-azobenzene-platinum-ii-complexes-in-cisplatin-resistant-ovarian-cancer-cells
#4
Katia G Samper, Sierra C Marker, Pau Bayón, Samantha N MacMillan, Ivan Keresztes, Òscar Palacios, Justin J Wilson
The syntheses of three platinum(II) complexes bearing sulfonamide-((E)-2-(4-methylphenylsulfonamido)-2',6'-difluoroazobenzene, HL1) and hydroxy-azo-2,6-difluorobenzene ((E)-2-((2,6-difluorophenyl)diazenyl)phenol, HL2) bidentate ligands is described. These complexes, [Pt(L1)(DMSO)Cl] (1), [Pt(L2)(DMSO)Cl] (2), and [Pt(L2)2] (3), were characterized by multinuclear NMR spectroscopy, mass spectrometry, and X-ray crystallography. Despite bearing azobenzene functional groups, none of the three complexes undergo photoisomerization...
August 8, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28798084/a-small-population-of-liver-endothelial-cells-undergoes-endothelial-to-mesenchymal-transition-in-response-to-chronic-liver-injury
#5
Jordi Ribera, Montse Pauta, Pedro Melgar-Lesmes, Bernat Cordoba, Anna Bosch, Maria Calvo, Daniel Rodrigo-Torres, Pau Sancho-Bru, Aurea Mira, Wladimiro Jimenez, Manuel Morales-Ruiz
BACKGROUND AND AIMS: Rising evidence points to endothelial-to-mesenchymal transition (EndMT) as a significant source of the mesenchymal cell population in fibrotic diseases. In this context, we hypothesized that liver endothelial cells undergo EndMT during fibrosis progression. METHODS: Cirrhosis in mice was induced by CCl4 A transgenic mouse expressing a red fluorescent protein reporter under the control of Tie2 promoter (Tie2-tdTomato) was used to trace the acquisition of EndMT...
August 10, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28796588/obinutuzumab-or-rituximab-plus-cyclophosphamide-doxorubicin-vincristine-and-prednisone-in-previously-untreated-diffuse-large-b-cell-lymphoma
#6
Umberto Vitolo, Marek Trněný, David Belada, John M Burke, Angelo Michele Carella, Neil Chua, Pau Abrisqueta, Judit Demeter, Ian Flinn, Xiaonan Hong, Won Seog Kim, Antonio Pinto, Yuan-Kai Shi, Yoichi Tatsumi, Mikkel Z Oestergaard, Michael Wenger, Günter Fingerle-Rowson, Olivier Catalani, Tina Nielsen, Maurizio Martelli, Laurie H Sehn
Purpose Rituximab (R) plus CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy is the standard of care in previously untreated diffuse large B-cell lymphoma (DLBCL). Obinutuzumab (G) is a glycoengineered, type II, anti-CD20 monoclonal antibody. GOYA was a randomized phase III study that compared G-CHOP with R-CHOP in patients with previously untreated advanced-stage DLBCL. Methods Patients (N = 1,418) were randomly assigned to receive eight 21-day cycles of G (n = 706) or R (n = 712), plus six or eight cycles of CHOP...
August 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28795953/diagnostic-accuracy-of-breath-tests-for-pneumoconiosis-using-an-electronic-nose
#7
Pau-Chung Chen, Hsin-Yi Peng, Che-Jui Chang, Hsiao-Yu Yang
Breath analyses have attracted substantial attention as screens for occupational environmental lung disease. The objective of this study was to develop breath tests for pneumoconiosis by analysing volatile organic compounds using an electronic nose. A case-control study was designed. We screened 102 subjects from a cohort of stone workers. After excluding three subjects with poorly controlled diabetes mellitus and one subject with asthma, 98 subjects were enrolled, including 34 subjects with pneumoconiosis and 64 healthy controls...
August 10, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28795535/update-on-postdialysis-rebound-by-a-new-technology-in-hemodialysis
#8
Alicia García Testal, David Hervás Marín, Rafael García Maset, Pilar Royo Maicas, Inmaculada Soledad Rico Salvador, Pau Olagüe Díaz, Jose Enrique Fernández Najera, Eduardo Torregrosa De Juan, Caterina Benedito Carrera
After dialysis ends, urea continued movement causes rebound postdialysis, with values at about 20%. New techniques have been incorporated into hemodialysis, but their relationship with rebound has not yet been studied. This study aimed to quantify urea rebound at 30-min postdialysis during sessions using polysulfone filters and high-flow versus online hemodiafiltration, and to define its correlation with body composition measured by bioimpedance by a cross-sectional study with 69 patients (December 2015 to January 2016)...
August 9, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28794215/male-relatedness-and-familiarity-are-required-to-modulate-male-induced-harm-to-females-in-drosophila
#9
Sally Le Page, Irem Sepil, Ewan Flintham, Tommaso Pizzari, Pau Carazo, Stuart Wigby
Males compete over mating and fertilization, and often harm females in the process. Inclusive fitness theory predicts that increasing relatedness within groups of males may relax competition and discourage male harm of females as males gain indirect benefits. Recent studies in Drosophila melanogaster are consistent with these predictions, and have found that within-group male relatedness increases female fitness, though others have found no effects. Importantly, these studies did not fully disentangle male genetic relatedness from larval familiarity, so the extent to which modulation of harm to females is explained by male familiarity remains unclear...
August 16, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28775194/development-of-a-prioritisation-tool-for-the-updating-of-clinical-guideline-questions-the-uppriority-tool-protocol
#10
Laura Martínez García, Hector Pardo-Hernandez, Ena Niño de Guzman, Cecilia Superchi, Monica Ballesteros, Emma McFarlane, Katrina Penman, Margarita Posso, Marta Roqué I Figuls, Andrea Juliana Sanabria, Anna Selva, Robin Wm Vernooij, Pablo Alonso-Coello
INTRODUCTION: Due to a continuous emergence of new evidence, clinical guidelines (CGs) require regular surveillance of evidence to maintain their trustworthiness. The updating of CGs is resource intensive and time consuming; therefore, updating may include a prioritisation process to efficiently ensure recommendations remain up to date. The objective of our project is to develop a pragmatic tool to prioritise clinical questions for updating within a CG. METHODS AND ANALYSIS: To develop the tool, we will use the results and conclusions of a systematic review of methodological research on prioritisation processes for updating and will adopt a methodological approach we have successfully implemented in a previous experience...
August 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28773200/interaction-of-shear-and-rayleigh-lamb-waves-with-notches-and-voids-in-plate-waveguides
#11
Annamaria Pau, Dimitra V Achillopoulou
This paper investigates the interaction of different shear- and Rayleigh-Lamb-guided waves in plates with a discontinuity such as a notch or an internal void. The problem was solved numerically using a finite element model and by exploiting an analytical solution obtainable for the double sharp changes of the cross-section that served as a reference. We aimed to elucidate the relation between the size and shape of the discontinuity and the reflection and transmission coefficients of the scattered field. Different sizes and profiles of the discontinuity were considered, with the shapes ranging from step changes of the height to ellipses, both symmetric and nonsymmetric...
July 21, 2017: Materials
https://www.readbyqxmd.com/read/28769893/imported-zika-virus-in-a-european-city-how-to-prevent-local-transmission
#12
Joan-Pau Millet, Tomàs Montalvo, Ruben Bueno-Marí, Arancha Romero-Tamarit, Albert Prats-Uribe, Lidia Fernández, Esteve Camprubí, Lucía Del Baño, Victor Peracho, Jordi Figuerola, Elena Sulleiro, Miguel J Martínez, Joan A Caylà
Background: On February 1st 2016 the WHO declared the Zika Virus (ZIKV) infection a worldwide public health emergency because of its rapid expansion and severe complications, such as Guillain-Barré Syndrome or microcephaly in newborn. The huge amount of people traveling to endemic areas and the presence of Aedes albopictus in Barcelona increase the risk of autochtonous transmission. The objective of this study was to describe the first ZIKV cases diagnosed in our city and to analyze the surveillance, prevention, and control measures implemented to avoid autochthonous transmission...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28756355/a-validated-hplc-uv-method-for-the-analysis-of-galloylquinic-acid-derivatives-and-flavonoids-in-copaifera-langsdorffii-leaves
#13
Erick Vicente da Silva Motta, Juliana de Carvalho da Costa, Jairo Kenupp Bastos
Copaifera langsdorffii Desf. (Fabaceae, Caesalpinioideae), popularly known as "copaiba" or "pau d'óleo", is a species of tree that is found throughout Brazil. The leaves of this tree are used in folk medicine to treat kidney stones. Galloylquinic acid derivatives and flavonoids are the main secondary metabolites found in C. langsdorffii leaves and are likely to be responsible for the effectiveness of this treatment. As an attempt to produce a phytotherapic, we have developed a reliable HPLC-UV method for the quality control of C...
July 18, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28755589/children-s-environmental-health-based-on-birth-cohort-studies-of-asia
#14
Meng-Shan Tsai, Mei-Huei Chen, Ching-Chun Lin, Sharon Ng, Chia-Jung Hsieh, Chen-Yu Liu, Wu-Shiun Hsieh, Pau-Chung Chen
Numerous studies have explored the associations between environmental pollutants and pediatric health. Recent studies have investigated the issue in Asia, but no systematic review has been published to date. This study aims to elucidate the issue by summarizing relevant epidemiologic evidence for cohorts in Asia, using information from the Birth Cohort Consortium of Asia (BiCCA). Environmental pollutants include mercury, environmental tobacco smoke (ETS), polychlorinated biphenyls (PCB), perfluoroalkyl substances (PFAS) and phthalates...
July 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28751557/the-bet-bromodomain-inhibitor-cpi203-improves-lenalidomide-and-dexamethasone-activity-in-in-vitro-and-in-vivo-models-of-multiple-myeloma-by-blockade-of-ikaros-and-myc-signaling
#15
Tania Díaz, Vanina Rodríguez, Ester Lozano, Mari-Pau Mena, Marcos Calderón, Laura Rosiñol, Antonio Martínez, Natalia Tovar, Patricia Pérez-Galán, Joan Bladé, Gaël Roué, Carlos Fernández de Larrea
Most of patients with multiple myeloma treated with current therapies, including immunomodulatory drugs, eventually develop relapsed/refractory disease. Clinical activity of lenalidomide relies on degradation of Ikaros and the consequently reduction on IRF4 expression, both required for myeloma cell survival and involved in the regulation of MYC transcription. Thus, we sought to determine the combinatorial effect of a MYC-interfering therapy with lenalidomide/dexamethasone. We analyzed the potential therapeutic effect of the combination of BET bromodomain inhibitor CPI203 with the lenalidomide/dexamethasone regimen in myeloma cell lines...
July 27, 2017: Haematologica
https://www.readbyqxmd.com/read/28747040/glycative-and-oxidative-stress-are-associated-with-altered-thrombus-composition-in-diabetic-patients-with-st-elevation-myocardial-infarction
#16
Antonia Sambola, Marisol Ruiz-Meana, Ignasi Barba, Bruno García Del Blanco, José A Barrabés, G Y Lip, Úrsula Vilardosa, Sara Sansaloni, Pau Rello, David García-Dorado
BACKGROUND: The role of type 2 diabetes (T2DM) on composition of thrombus has not been fully characterized in patients with ST-elevation myocardial infarction (STEMI). AIMS: To elucidate the differences between diabetic and non-diabetic patients with STEMI in relation to the composition of coronary thrombus, and the potential association of these differences with glycated haemoglobin levels and markers of oxidative stress. METHODS: Intracoronary thrombi from consecutive thrombus aspiration procedures in STEMI patients, 25 diabetic and 28 non-diabetic, were analyzed by immunofluorescence with confocal microscopy...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28744991/utility-of-high-density-multielectrode-mapping-during-ablation-of-scar-related-ventricular-tachycardia
#17
Óscar Cano, Diego Plaza, Assumpció Saurí, Joaquín Osca, Pau Alonso, Ana Andrés, María-José Sancho-Tello, Luis Martínez-Dolz
INTRODUCTION: Multielectrode mapping catheters (MEMC) allow the performance of high resolution and density maps but the utility of these catheters in ventricular tachycardia (VT) ablation procedures has not been yet widely described. We sought to evaluate the utility of a MEMC during scar-related VT ablation procedures. METHODS: 85 consecutive scar-related VT ablation procedures were performed in 81 patients. In the first 26 procedures, a standard 3.5 mm tip linear catheter was employed for endocardial/epicardial mapping (control group)...
July 26, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28735216/elastic-properties-and-strain-to-crack-initiation-of-calcium-phosphate-bone-cements-revelations-of-a-high-resolution-measurement-technique
#18
Ingrid Ajaxon, Alice Acciaioli, Giacomo Lionello, Maria-Pau Ginebra, Caroline Öhman-Mägi, Massimiliano Baleani, Cecilia Persson
Calcium phosphate cements (CPCs) should ideally have mechanical properties similar to those of the bone tissue the material is used to replace or repair. Usually, the compressive strength of the CPCs is reported and, more rarely, the elastic modulus. Conversely, scarce or no data are available on Poisson's ratio and strain-to-crack-initiation. This is unfortunate, as data on the elastic response is key to, e.g., numerical model accuracy. In this study, the compressive behaviour of brushite, monetite and apatite cements was fully characterised...
June 21, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28731109/the-preference-for-dual-gold-i-catalysis-in-the-hydro-alkoxylation-vs-phenoxylation-of-alkynes
#19
Èric Casals-Cruañas, Oscar F González-Belman, Pau Besalú-Sala, David J Nelson, Albert Poater
Dinuclear gold complexes and their use in catalysis have received significant recent attention, but there are few critical comparisons of mono- versus dual gold-catalysed pathways. Herein we study the hydroalkoxylation and hydrophenoxylation of alkynes using density functional theory calculations, and compare two possible mechanisms that have been proposed previously on the basis of theoretical and experimental studies, which unravel different preferences because of both the nature of the alkyne and alcohol and the non-innocent role of the counter-anion of a dual gold based catalyst...
August 2, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28729547/antarctic-sea-ice-region-as-a-source-of-biogenic-organic-nitrogen-in-aerosols
#20
Manuel Dall'Osto, Jurgita Ovadnevaite, Marco Paglione, David C S Beddows, Darius Ceburnis, Charlotte Cree, Pau Cortés, Marina Zamanillo, Sdena O Nunes, Gonzalo L Pérez, Eva Ortega-Retuerta, Mikhail Emelianov, Dolors Vaqué, Cèlia Marrasé, Marta Estrada, M Montserrat Sala, Montserrat Vidal, Mark F Fitzsimons, Rachael Beale, Ruth Airs, Matteo Rinaldi, Stefano Decesari, Maria Cristina Facchini, Roy M Harrison, Colin O'Dowd, Rafel Simó
Climate warming affects the development and distribution of sea ice, but at present the evidence of polar ecosystem feedbacks on climate through changes in the atmosphere is sparse. By means of synergistic atmospheric and oceanic measurements in the Southern Ocean near Antarctica, we present evidence that the microbiota of sea ice and sea ice-influenced ocean are a previously unknown significant source of atmospheric organic nitrogen, including low molecular weight alkyl-amines. Given the keystone role of nitrogen compounds in aerosol formation, growth and neutralization, our findings call for greater chemical and source diversity in the modelling efforts linking the marine ecosystem to aerosol-mediated climate effects in the Southern Ocean...
July 20, 2017: Scientific Reports
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