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https://www.readbyqxmd.com/read/29777604/-ethical-aspects-of-the-use-of-mirena-r-iud-in-the-treatment-of-heavy-menstrual-bleeding
#1
Miriam Turiel Miranda, Pau Agulles Simó
The levonorgestrel-releasing intrauterine device known as Mirena IUD(r) (20mcg/24h) is nowadays considered among the leading resources in the treatment of heavy menstrual bleeding. Nonetheless, due to either its effect of prevention of conception and especially to the possibility that it may also have an anti-implantation effect, there is a founded concern on whether its therapeutic use may be ethically licit. This article engages in an exhaustive literature review in order to ascertain the mechanism of action of Mirena(r) IUD, in view of an ethical evaluation of its therapeutic use, keeping in mind those two unwanted effects...
May 2018: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/29777432/qualitative-study-of-mechanical-parameters-of-conventional-diagnostic-x-ray-machines-in-mizoram
#2
Jonathan Lalrinmawia, Kham Suan Pau, Ramesh Chandra Tiwari
The present study examined the mechanical attributes of 135 conventional diagnostic X-ray machines in Mizoram, India. The purpose of studying the X-ray mechanical parameters, such as congruency, perpendicularity of the central beam, and half-value layer, was to improve the quality of the diagnostic image and reduce the patient dose. A battery-operated portable dosimeter was used to measure output radiation of the X-ray machine. The half-value layer was measured at a constant accelerating potential of 70 kVp and tube load...
May 18, 2018: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29773482/a-model-for-leptospire-dynamics-and-control-in-the-norway-rat-rattus-norvegicus-the-reservoir-host-in-urban-slum-environments
#3
Amanda Minter, Peter J Diggle, Federico Costa, James Childs, Albert I Ko, Mike Begon
Leptospirosis is a zoonosis that humans can contract via contact with animal reservoirs directly or with water contaminated with their urine. The primary reservoir of pathogenic leptospires within urban slum environments is the Norway rat (Rattus norvegicus). Motivated by the annual outbreaks of human leptospirosis in slum urban settings, the within population infection dynamics of the Norway rat were investigated in Pau da Lima, an community in Salvador, Brazil. A mechanistic model of the dynamics of leptospire infection was informed by extensive field and laboratory data was developed and explored analytically...
May 5, 2018: Epidemics
https://www.readbyqxmd.com/read/29766010/single-stage-endovascular-treatment-of-a-penetrating-aortic-ulcer-with-a-concomitant-isolated-iliac-aneurysm
#4
Haidi Hu, Jianming Guo, Hualong Bai, Alan Dardik
Penetrating aortic ulcer (PAU) is an acute aortic syndrome that can proceed to life-threatening aortic dissection or even aortic rupture. Isolated iliac aneurysms are relatively rare and often asymptomatic due to their deep pelvic location but are frequently associated with high mortality with rupture. We report a case of a 68-year-old man with a symptomatic penetrating ulcer in the descending aorta and an asymptomatic right iliac aneurysm involving the common and internal iliac arteries. The patient was successfully treated by endovascular repair in a single-stage manner using stent grafts in the descending aorta and right common iliac artery after coil embolization of the right internal iliac artery...
December 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/29756855/post-newtonian-dynamics-in-dense-star-clusters-highly-eccentric-highly-spinning-and-repeated-binary-black-hole-mergers
#5
Carl L Rodriguez, Pau Amaro-Seoane, Sourav Chatterjee, Frederic A Rasio
We present models of realistic globular clusters with post-Newtonian dynamics for black holes. By modeling the relativistic accelerations and gravitational-wave emission in isolated binaries and during three- and four-body encounters, we find that nearly half of all binary black hole mergers occur inside the cluster, with about 10% of those mergers entering the LIGO/Virgo band with eccentricities greater than 0.1. In-cluster mergers lead to the birth of a second generation of black holes with larger masses and high spins, which, depending on the black hole natal spins, can sometimes be retained in the cluster and merge again...
April 13, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29751433/childhood-exposure-to-phthalates-and-pulmonary-function
#6
Liang-Yu Lin, Meng-Shan Tsai, Mei-Huei Chen, Sharon Ng, Chia-Jung Hsieh, Ching-Chun Lin, Frank Leigh Lu, Wu-Shiun Hsieh, Pau-Chung Chen
Phthalate exposure is related to the development of allergic diseases; however, studies regarding its effect on lung function are limited. Our study aims to identify an association between phthalate exposure at different ages and lung function in children at age 9 by conducting a cohort study. The Taiwan Birth Panel Study (TBPS) was established from April 2004 to January 2005. Urine samples were collected from children in the TBPS cohort at ages 2, 5, and 9years. Urinary phthalate metabolite concentrations were measured via ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29751090/sex-dependent-and-sex-independent-muscle-activation-patterns-in-adult-gait-as-a-function-of-age
#7
Christopher A Bailey, Federica Corona, Giuseppina Pilloni, Micaela Porta, Maria Chiara Fastame, Paul Kenneth Hitchcott, Maria Pietronilla Penna, Massimiliano Pau, Julie N Côté
INTRODUCTION: Aging leads to poorer neuromuscular control that may impact mobility. However, the specific decades when these changes occur, and whether these time-based changes are sex-specific, are unclear. METHODS: Adults aged 20-82 years (N = 93, 51 females) walked six gait trials at their preferred speed over a 10-m platform. Electromyography (EMG) of the rectus femoris (RF), tibialis anterior (TA), and gastrocnemius lateralis (GL) were measured using wireless surface sensors...
May 8, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29747028/all-in-one-trifunctional-strategy-a-cell-adhesive-bacteriostatic-and-bactericidal-coating-for-titanium-implants
#8
Mireia Hoyos-Nogués, Judit Buxadera-Palomero, Maria-Pau Ginebra, José María Manero, F J Gil, Carlos Mas-Moruno
Strategies to inhibit initial bacterial adhesion are extremely important to prevent infection on biomaterial surfaces. However, the simultaneous attraction of desired eukaryotic cells remains a challenge for successful biomaterial-host tissue integration. Here we describe a method for the development of a trifunctional coating that repels contaminating bacteria, kills those that adhere, and promotes osteoblast adhesion. To this end, titanium surfaces were functionalized by electrodeposition of an antifouling polyethylene glycol (PEG) layer and subsequent binding of a peptidic platform with cell-adhesive and bactericidal properties...
April 27, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29746490/clinical-evaluation-of-semi-automatic-open-source-algorithmic-software-segmentation-of-the-mandibular-bone-practical-feasibility-and-assessment-of-a-new-course-of-action
#9
Jürgen Wallner, Kerstin Hochegger, Xiaojun Chen, Irene Mischak, Knut Reinbacher, Mauro Pau, Tomislav Zrnc, Katja Schwenzer-Zimmerer, Wolfgang Zemann, Dieter Schmalstieg, Jan Egger
INTRODUCTION: Computer assisted technologies based on algorithmic software segmentation are an increasing topic of interest in complex surgical cases. However-due to functional instability, time consuming software processes, personnel resources or licensed-based financial costs many segmentation processes are often outsourced from clinical centers to third parties and the industry. Therefore, the aim of this trial was to assess the practical feasibility of an easy available, functional stable and licensed-free segmentation approach to be used in the clinical practice...
2018: PloS One
https://www.readbyqxmd.com/read/29743114/igm-and-igg-against-plasmodium-falciparum-lysate-as-surrogates-of-malaria-exposure-and-protection-during-pregnancy
#10
Alfredo Mayor, Carlota Dobaño, Augusto Nhabomba, Caterina Guinovart, Alfons Jiménez, Maria Nelia Manaca, Ruth Aguilar, Arnoldo Barbosa, Mauricio H Rodríguez, Pau Cisteró, Lazaro M Quimice, Clara Menéndez, John J Aponte, Jaume Ordi, Chetan E Chitnis, Pedro L Alonso
BACKGROUND: Difficulties to disentangle the protective versus exposure role of anti-malarial antibodies hamper the identification of clinically-relevant immune targets. Here, factors affecting maternal IgG and IgMs against Plasmodium falciparum antigens, as well as their relationship with parasite infection and clinical outcomes, were assessed in mothers and their children. Antibody responses among 207 Mozambican pregnant women at delivery against MSP119 , EBA175, AMA1, DBLα and parasite lysate (3D7, R29 and E8B parasite lines), as well as the surface of infected erythrocytes, were assessed by enzyme-linked immunosorbent assay and flow cytometry...
May 10, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29740605/active-nematic-emulsions
#11
Pau Guillamat, Žiga Kos, Jérôme Hardoüin, Jordi Ignés-Mullol, Miha Ravnik, Francesc Sagués
The formation of emulsions from multiple immiscible fluids is governed by classical concepts such as surface tension, differential chemical affinity and viscosity, and the action of surface-active agents. Much less is known about emulsification when one of the components is active and thus inherently not constrained by the laws of thermodynamic equilibrium. We demonstrate one such realization consisting in the encapsulation of an active liquid crystal (LC)-like gel, based on microtubules and kinesin molecular motors, into a thermotropic LC...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29728589/all-trans-retinoic-acid-activates-the-pro-invasive-src-yap-interleukin-6-axis-in-triple-negative-mda-mb-231-breast-cancer-cells-while-cerivastatin-reverses-this-action
#12
Belén Mezquita, Pau Mezquita, Montserrat Pau, Laura Gasa, Lourdes Navarro, Mireia Samitier, Miquel Pons, Cristóbal Mezquita
All-trans-retinoic acid (RA), the active metabolite of vitamin A, can reduce the malignant phenotype in some types of cancer and paradoxically also can promote cancer growth and invasion in others. For instance, it has been reported that RA induces tumor suppression in tumor xenografts of MDA-MB-468 breast cancer cells while increasing tumor growth and metastases in xenografts of MDA-MB-231 breast cancer cells. The signaling pathways involved in the pro-invasive action of retinoic acid remain mostly unknown...
May 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29728418/understanding-case-mix-across-three-paediatric-services-could-integration-of-primary-and-secondary-general-paediatrics-alter-walk-in-emergency-attendances
#13
Lloyd Steele, Nicky Coote, Robert Klaber, Mando Watson, Michael Coren
OBJECTIVE: To understand the case mix of three different paediatric services, reasons for using an acute paediatric service in a region of developing integrated care and where acute attendances could alternatively have been managed. METHODS: Mixed methods service evaluation, including retrospective review of referrals to general paediatric outpatients (n=534) and a virtual integrated service (email advice line) (n=474), as well as a prospective survey of paediatric ambulatory unit (PAU) attendees (n=95) and review by a paediatric consultant/registrar to decide where these cases could alternatively have been managed...
May 4, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29720720/gamma-aminobutyric-acid-gaba-receptors-genes-polymorphisms-and-risk-for-restless-legs-syndrome
#14
Félix Javier Jiménez-Jiménez, Gara Esguevillas, Hortensia Alonso-Navarro, Martín Zurdo, Laura Turpín-Fenoll, Jorge Millán-Pascual, Teresa Adeva-Bartolomé, Esther Cubo, Francisco Navacerrada, Gemma Amo, Ana Rojo-Sebastián, Lluisa Rubio, Mónica Díez-Fairén, Pau Pastor, Marisol Calleja, José Francisco Plaza-Nieto, Belén Pilo-de-la-Fuente, Margarita Arroyo-Solera, Esteban García-Albea, José A G Agúndez, Elena García-Martín
The possible role of gammaaminobutyric acid (GABA) in the pathophysiology of restless legs syndrome (RLS) is suggested by the symptomatic improvement achieved with GABAergic drugs. Thalamic GABA levels have shown positive correlation with periodic limb movements indices and with RLS severity. We tried to investigate the possible association between the most common single nucleotide polymorphisms (SNPs) in the GABA receptors (GABR) genes rho1, 2, and 3 (GABRR1, GABRR2, GABRR3), alpha4 (GABRA4), epsilon (GABRE), and theta (GABRQ) with the risk of developing RLS...
May 3, 2018: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29719613/a-trpv2-interactome-based-signature-for-prognosis-in-glioblastoma-patients
#15
Pau Doñate-Macián, Antonio Gómez, Irene R Dégano, Alex Perálvarez-Marín
Proteomics aids to the discovery and expansion of protein-protein interaction networks, which are key to understand molecular mechanisms in physiology and physiopathology, but also to infer protein function in a guilt-by-association fashion. In this study we use a systematic protein-protein interaction membrane yeast two-hybrid method to expand the interactome of TRPV2, a cation channel related to nervous system development. After validation of the interactome in silico , we define a TRPV2-interactome signature combining proteomics with the available physio-pathological data in Disgenet to find interactome-disease associations, highlighting nervous system disorders and neoplasms...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29718111/genomicscores-seamless-access-to-genomewide-position-specific-scores-from-r-and-bioconductor
#16
Pau Puigdevall, Robert Castelo
Summary: Genomewide position-specific scores, such as those estimating conservation, constraint, fitness or mutation tolerance, are ubiquitous in current genome analyses. The diversity of sources and formats of these scores, as well as their size, increase the burden to use them. We present GenomicScores, a Bioconductor package that provides efficient storage and seamless access of genomewide position-specific scores from R, facilitating their use in genome analysis workflows. Availability and implementation: GenomicScores is implemented in R and available at https://bioconductor...
April 26, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29702122/temporally-dissociable-effects-of-ketamine-on-neuronal-discharge-and-gamma-oscillations-in-rat-thalamo-cortical-networks
#17
Maria Amat-Foraster, Anders A Jensen, Niels Plath, Kjartan F Herrik, Pau Celada, Francesc Artigas
BACKGROUND: Sub-anesthetic doses of the non-competitive N-methyl-d-aspartate receptor (NMDA-R) antagonist ketamine evoke transient psychotomimetic effects, followed by persistent antidepressant effects in treatment-resistant depressed patients and rodents through still poorly understood mechanisms. Since phencyclidine (PCP) disinhibits thalamo-cortical networks by blocking NMDA-Rs on GABAergic neurons of the reticular thalamic nucleus (RtN), we examined ketamine's actions in the same areas...
April 24, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29701406/infrarenal-abdominal-penetrating-aortic-ulcer-an-atypical-location-of-a-rare-disease
#18
Nelson Camacho, Gonçalo Rodrigues, Rodolfo Abreu, Rita Ferreira, Joana Catarino, Ricardo Correia, Rita Bento, Maria Emília Ferreira
INTRODUCTION: Penetrating aortic ulcer (PAU) is classically included in acute aortic syndromes, together with aortic dissection and intramural hematoma. These three disorders are considered different stages of the same disease. PAU is the result of medial degeneration with disruption of the intima, mainly due to atherosclerotic risk factors. Most of them are located on descending thoracic aorta and only a few small series and case reports demonstrate location on infrarenal abdominal aorta...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29692703/pleiotropic-effects-of-variants-in-dementia-genes-in-parkinson-disease
#19
Laura Ibanez, Umber Dube, Albert A Davis, Maria V Fernandez, John Budde, Breanna Cooper, Monica Diez-Fairen, Sara Ortega-Cubero, Pau Pastor, Joel S Perlmutter, Carlos Cruchaga, Bruno A Benitez
Background: The prevalence of dementia in Parkinson disease (PD) increases dramatically with advancing age, approaching 80% in patients who survive 20 years with the disease. Increasing evidence suggests clinical, pathological and genetic overlap between Alzheimer disease, dementia with Lewy bodies and frontotemporal dementia with PD. However, the contribution of the dementia-causing genes to PD risk, cognitive impairment and dementia in PD is not fully established. Objective: To assess the contribution of coding variants in Mendelian dementia-causing genes on the risk of developing PD and the effect on cognitive performance of PD patients...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29689118/correction-a-prophylactic-multivalent-vaccine-against-different-filovirus-species-is-immunogenic-and-provides-protection-from-lethal-infections-with-ebolavirus-and-marburgvirus-species-in-non-human-primates
#20
Benoit Callendret, Jort Vellinga, Kerstin Wunderlich, Ariane Rodriguez, Robin Steigerwald, Ulrike Dirmeier, Cedric Cheminay, Ariane Volkmann, Trevor Brasel, Ricardo Carrion, Luis D Giavedoni, Jean L Patterson, Chad E Mire, Thomas W Geisbert, Jay W Hooper, Mo Weijtens, Jutta Hartkoorn-Pasma, Jerome Custers, Maria Grazia Pau, Hanneke Schuitemaker, Roland Zahn
[This corrects the article DOI: 10.1371/journal.pone.0192312.].
2018: PloS One
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