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Psychosis Hippocampus

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https://www.readbyqxmd.com/read/28087359/the-effect-of-nmda-r-antagonism-on-simultaneously-acquired-local-field-potentials-and-tissue-oxygen-levels-in-the-brains-of-freely-moving-rats
#1
John Kealy, Sean Commins, John P Lowry
Non-competitive NMDA receptor antagonists are known to induce psychosis-like symptoms in rodents. Administration of such compounds cause behavioural effects such as memory impairment and hyperlocomotion. Additionally, drugs such as phencyclidine (PCP), ketamine and MK-801 all cause distinctive increases in striatal local field potential (LFP) in the high frequency oscillation (HFO) band in the power spectrum (140-180 Hz). Amperometric sensors provide a means to measure tissue oxygen (tO2; a BOLD-like signal) in the brains of freely-moving rats while simultaneously acquiring LFP using the same electrode...
January 10, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28079061/progressive-decline-in-hippocampal-ca1-volume-in-individuals-at-ultra-high-risk-for-psychosis-who-do-not-remit-findings-from-the-longitudinal-youth-at-risk-study
#2
New Fei Ho, Daphne J Holt, Mike Cheung, Juan Eugenio Iglesias, Alex Goh, Mingyuan Wang, Joseph Kw Lim, Joshua de Souza, Joann S Poh, Yuen Mei See, Alison R Adcock, Stephen J Wood, Michael Wl Chee, Jimmy Lee, Juan Zhou
Most individuals identified as ultra high-risk for psychosis (UHR) do not develop frank psychosis. They continue to exhibit subthreshold symptoms, or go on to fully remit. Prior work has shown that the volume of CA1, a subfield of the hippocampus, is selectively reduced in the early stages of schizophrenia. Here, we aimed to determine whether patterns of volume change of CA1 are different in UHR individuals who do or do not achieve symptomatic remission. Structural MRI scans were acquired at baseline and at 1-2 follow-up time points (at 12-month intervals) from 147 UHR and healthy control subjects...
January 12, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28053019/biological-mechanisms-whereby-social-exclusion-may-contribute-to-the-etiology-of-psychosis-a-narrative-review
#3
Jean-Paul Selten, Jan Booij, Bauke Buwalda, Andreas Meyer-Lindenberg
The purpose of this review is to examine whether a contribution of social exclusion to the pathogenesis of psychosis is compatible with the dopamine hypothesis and/or the neurodevelopmental hypothesis. Humans experience social exclusion as defeating. An animal model for defeat is the resident-intruder paradigm. The defeated animal shows evidence of an increased sensitivity to amphetamine, increased dopamine release in the nucleus accumbens and prefrontal cortex, and increased firing of dopaminergic neurons in the ventral tegmental area...
January 3, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27942450/impact-of-schizophrenia-on-anterior-and-posterior-hippocampus-during-memory-for-complex-scenes
#4
J D Ragland, E Layher, D E Hannula, T A Niendam, T A Lesh, M Solomon, C S Carter, C Ranganath
OBJECTIVES: Hippocampal dysfunction has been proposed as a mechanism for memory deficits in schizophrenia. Available evidence suggests that the anterior and posterior hippocampus could be differentially affected. Accordingly, we used fMRI to test the hypothesis that activity in posterior hippocampus is disproportionately reduced in schizophrenia, particularly during spatial memory retrieval. METHODS: 26 healthy participants and 24 patients with schizophrenia from the UC Davis Early Psychosis Program were studied while fMRI was acquired on a 3 Tesla Siemens scanner...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27853241/supplementation-with-d-serine-prevents-the-onset-of-cognitive-deficits-in-adult-offspring-after-maternal-immune-activation
#5
Yuko Fujita, Tamaki Ishima, Kenji Hashimoto
Prenatal maternal infection contributes to the etiology of schizophrenia, with D-serine, an endogenous co-agonist of the N-methyl-D-aspartate (NMDA) receptor, playing a role in the pathophysiology of this disease. We examined whether supplementation with D-serine during juvenile and adolescent stages could prevent the onset of cognitive deficits, prodromal and the core symptoms of schizophrenia in adult offspring after maternal immune activation (MIA). Juvenile offspring exposed prenatally to poly(I:C) showed reduced expression of NMDA receptor subunits in the hippocampus...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27824119/intake-of-7-8-dihydroxyflavone-during-juvenile-and-adolescent-stages-prevents-onset-of-psychosis-in-adult-offspring-after-maternal-immune-activation
#6
Mei Han, Ji-Chun Zhang, Wei Yao, Chun Yang, Tamaki Ishima, Qian Ren, Min Ma, Chao Dong, Xu-Feng Huang, Kenji Hashimoto
Prenatal infection and subsequent abnormal neurodevelopment of offspring is involved in the etiology of schizophrenia. Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role in the neurodevelopment. Pregnant mice exposed to polyriboinosinic-polyribocytidylic acid [poly(I:C)] causes schizophrenia-like behavioral abnormalities in their offspring at adulthood. Here we found that the juvenile offspring of poly(I:C)-treated mice showed cognitive deficits, as well as reduced BDNF-TrkB signaling in the prefrontal cortex (PFC)...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27806441/acute-systemic-mk-801-induced-functional-uncoupling-between-hippocampal-areas-ca3-and-ca1-with-distant-effect-in-the-retrosplenial-cortex
#7
Helena Buchtová, Iveta Fajnerová, Aleš Stuchlík, Štěpán Kubík
The hippocampus and retrosplenial cortex are integrated within a higher-order cognitive circuit supporting relational (spatial, contextual, episodic) forms of learning and memory. Hippocampal place cells can coordinate multiple parallel representations in the same physical environment. Novel environment exploration triggers expression of immediate-early genes (IEGs) Arc and Homer1a in spatial context-specific ensembles of CA1 and CA3 neurons. Less is know about ensemble coding in the retrosplenial cortex (RSC), a region directly connected and functionally coupled to CA1...
November 2, 2016: Hippocampus
https://www.readbyqxmd.com/read/27738647/alterations-in-the-hippocampus-and-thalamus-in-individuals-at-high-risk-for-psychosis
#8
Fabienne Harrisberger, Roman Buechler, Renata Smieskova, Claudia Lenz, Anna Walter, Laura Egloff, Kerstin Bendfeldt, Andor E Simon, Diana Wotruba, Anastasia Theodoridou, Wulf Rössler, Anita Riecher-Rössler, Undine E Lang, Karsten Heekeren, Stefan Borgwardt
Reduction in hippocampal volume is a hallmark of schizophrenia and already present in the clinical high-risk state. Nevertheless, other subcortical structures, such as the thalamus, amygdala and pallidum can differentiate schizophrenia patients from controls. We studied the role of hippocampal and subcortical structures in clinical high-risk individuals from two cohorts. High-resolution T1-weighted structural MRI brain scans of a total of 91 clinical high-risk individuals and 64 healthy controls were collected in two centers...
2016: NPJ Schizophrenia
https://www.readbyqxmd.com/read/27723806/voxel-based-morphometry-in-individuals-at-genetic-high-risk-for-schizophrenia-and-patients-with-schizophrenia-during-their-first-episode-of-psychosis
#9
Miao Chang, Fay Y Womer, Chuan Bai, Qian Zhou, Shengnan Wei, Xiaowei Jiang, Haiyang Geng, Yifang Zhou, Yanqing Tang, Fei Wang
BACKGROUND: Understanding morphologic changes in vulnerable and early disease state of schizophrenia (SZ) may provide further insight into the development of psychosis. METHOD: Whole brain voxel-based morphometry was performed to identify gray matter (GM) regional differences in 60 individuals with SZ during their first psychotic episode (FE-SZ), 31 individuals at genetic high risk for SZ (GHR-SZ) individuals, and 71 healthy controls. RESULTS: Significant differences were found in several regions including the prefrontal cortex, parietal lobe, temporal lobe, hippocampus, occipital lobe, and cerebellum among the three groups (p<0...
2016: PloS One
https://www.readbyqxmd.com/read/27703766/the-effect-of-second-generation-antipsychotics-on-hippocampal-volume-in-first-episode-of-psychosis-longitudinal-study
#10
Michael Bodnar, Ashok K Malla, Carolina Makowski, M Mallar Chakravarty, Ridha Joober, Martin Lepage
BACKGROUND: Current neuroscience literature has related treatment with aripiprazole to improved memory performance and subcellular changes in the hippocampus. AIMS: To explore the volumetric changes in hippocampal grey matter in people with a first episode of psychosis (FEP) treated with second-generation antipsychotics. METHOD: Baseline and 1-year follow-up magnetic resonance images were obtained. Hippocampal volumes were estimated by using FreeSurfer and MAGeT-Brain...
March 2016: BJPsych Open
https://www.readbyqxmd.com/read/27644028/hippocampal-arterial-cerebral-blood-volume-in-early-psychosis
#11
Pratik Talati, Swati Rane, Manus J Donahue, Stephan Heckers
Recent studies of patients in the early stage of psychosis have revealed increased cerebral blood volume (CBV) in specific subfields of the anterior hippocampus. These studies required injection of a contrast agent to measure steady state CBV. Here we used a novel, non-invasive method, inflow-based-vascular-space-occupancy with dynamic subtraction (iVASO-DS), to measure the arterial component of CBV (aCBV) in a single slice of the hippocampus. Based on evidence from contrast-enhanced CBV studies, we hypothesized increased aCBV in the anterior hippocampus in early psychosis...
October 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27617779/abnormal-white-matter-integrity-in-synthetic-cannabinoid-users
#12
Nabi Zorlu, Maria Angelique Di Biase, Çiğdem Çolak Kalaycı, Andrew Zalesky, Başak Bağcı, Nihan Oğuz, Fazıl Gelal, Lütfullah Beşiroğlu, Şeref Gülseren, Aybala Sarıçiçek, Emre Bora, Christos Pantelis
Synthetic cannabinoids have become increasingly popular in the last few years especially among adolescents and young adults. However, no previous studies have assessed the effects of synthetic cannabinoids on the structure of the human brain. Understanding the harms of synthetic cannabinoid use on brain structure is therefore crucial given its increasing use. Diffusion tensor imaging (DTI) was performed in 22 patients who used synthetic cannabinoids more than five times a week for at least 1 year and 18 healthy controls...
November 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27609240/imaging-microglial-activation-in-untreated-first-episode-psychosis-a-pet-study-with-18-f-feppa
#13
Sina Hafizi, Huai-Hsuan Tseng, Naren Rao, Thiviya Selvanathan, Miran Kenk, Richard P Bazinet, Ivonne Suridjan, Alan A Wilson, Jeffrey H Meyer, Gary Remington, Sylvain Houle, Pablo M Rusjan, Romina Mizrahi
OBJECTIVE: Neuroinflammation and abnormal immune responses are increasingly implicated in the pathophysiology of schizophrenia. Previous positron emission tomography (PET) studies targeting the translocator protein 18 kDa (TSPO) have been limited by high nonspecific binding of the first-generation radioligand, low-resolution scanners, small sample sizes, and psychotic patients being on antipsychotics or not being in the first episode of their illness. The present study uses the novel second-generation TSPO PET radioligand [(18)F]FEPPA to evaluate whether microglial activation is elevated in the dorsolateral prefrontal cortex and hippocampus of untreated patients with first-episode psychosis...
September 9, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27559077/temporal-lobe-volume-decrements-in-psychosis-spectrum-youths
#14
David R Roalf, Megan Quarmley, Monica E Calkins, Theodore D Satterthwaite, Kosha Ruparel, Mark A Elliott, Tyler M Moore, Ruben C Gur, Raquel E Gur, Paul J Moberg, Bruce I Turetsky
Structural brain abnormalities have been amply demonstrated in schizophrenia. These include volume decrements in the perirhinal/entorhinal regions of the ventromedial temporal lobe, which comprise the primary olfactory cortex. Olfactory impairments, which are a hallmark of schizophrenia, precede the onset of illness, distinguish adolescents experiencing prodromal symptoms from healthy youths, and may predict the transition from the prodrome to frank psychosis. We therefore examined temporal lobe regional volumes in a large adolescent sample to determine if structural deficits in ventromedial temporal lobe areas were associated, not only with schizophrenia, but also with a heightened risk for psychosis...
August 24, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27550864/hippocampal-neural-disinhibition-causes-attentional-and-memory-deficits
#15
Stephanie McGarrity, Rob Mason, Kevin C Fone, Marie Pezze, Tobias Bast
Subconvulsive hippocampal neural disinhibition, that is reduced GABAergic inhibition, has been implicated in neuropsychiatric disorders characterized by attentional and memory deficits, including schizophrenia and age-related cognitive decline. Considering that neural disinhibition may disrupt both intra-hippocampal processing and processing in hippocampal projection sites, we hypothesized that hippocampal disinhibition disrupts hippocampus-dependent memory performance and, based on strong hippocampo-prefrontal connectivity, also prefrontal-dependent attention...
August 22, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27529801/subchronic-administration-of-phencyclidine-produces-hypermethylation-in-the-parvalbumin-gene-promoter-in-rat-brain
#16
Helene A Fachim, Umarat Srisawat, Caroline F Dalton, Michael K Harte, Samuel Marsh, Joanna C Neill, Gavin P Reynolds
AIM: A deficit in parvalbumin neurons is found in schizophrenia and several animal models of the disease. In this preliminary study, we determined whether one such model, phencyclidine (PCP) administration, results in changes in DNA methylation in the rat Pvalb promoter. MATERIALS & METHODS: DNA from hippocampus and prefrontal cortex from rats, which 6 weeks previously received either 2 mg/kg PCP or vehicle for 7 days, underwent bisulphite pyrosequencing to determine methylation...
September 2016: Epigenomics
https://www.readbyqxmd.com/read/27499362/subcortical-grey-matter-alterations-in-cocaine-dependent-individuals-with-substance-induced-psychosis-compared-to-non-psychotic-cocaine-users
#17
Taylor S Willi, Donna J Lang, William G Honer, Geoff N Smith, Allen E Thornton, William J Panenka, Ric M Procyshyn, Fidel Vila-Rodriguez, Wayne Su, A Talia Vertinsky, Olga Leonova, Alexander Rauscher, G William MacEwan, Alasdair M Barr
After prolonged psychostimulant abuse, transient psychotic symptoms referred to as "substance-induced psychosis" (SIP) can develop - closely resembling symptoms observed in schizophrenia spectrum disorders. The comparability in psychotic presentation between SIP and schizophrenias suggests that similar underlying neural deficits may contribute to the expression of psychosis across these disorders. To date, neuroanatomical characterization of grey matter structural alterations in SIP has been limited to methamphetamine associated psychosis, with no studies controlling for potential neurotoxic effects of the psychostimulant that precipitates psychosis...
October 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27459724/impaired-fornix-hippocampus-integrity-is-linked-to-peripheral-glutathione-peroxidase-in-early-psychosis
#18
P S Baumann, A Griffa, M Fournier, P Golay, C Ferrari, L Alameda, M Cuenod, J-P Thiran, P Hagmann, K Q Do, P Conus
Several lines of evidence implicate the fornix-hippocampus circuit in schizophrenia. In early-phase psychosis, this circuit has not been extensively investigated and the underlying mechanisms affecting the circuit are unknown. The hippocampus and fornix are vulnerable to oxidative stress at peripuberty in a glutathione (GSH)-deficient animal model. The purposes of the current study were to assess the integrity of the fornix-hippocampus circuit in early-psychosis patients (EP), and to study its relationship with peripheral redox markers...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27445871/emotionally-neutral-stimuli-are-not-neutral-in-schizophrenia-a-mini-review-of-functional-neuroimaging-studies
#19
REVIEW
Stéphane Potvin, Andràs Tikàsz, Adrianna Mendrek
Reliable evidence shows that schizophrenia patients tend to experience negative emotions when presented with emotionally neutral stimuli. Similarly, several functional neuroimaging studies show that schizophrenia patients have increased activations in response to neutral material. However, results are heterogeneous. Here, we review the functional neuroimaging studies that have addressed this research question. Based on the 36 functional neuroimaging studies that we retrieved, it seems that the increased brain reactivity to neutral stimuli is fairly common in schizophrenia, but that the regions involved vary considerably, apart from the amygdala...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27429684/correlations-of-clusters-of-non-convulsive-seizure-and-magnetic-resonance-imaging-in-a-case-with-gad65-positive-autoimmune-limbic-encephalitis
#20
Rachael Gardner, Rajesh Rangaswamy, Yen-Yi Peng
With the increased availability of laboratory tests, glutamic acid decarboxylase (GAD) antibody-positive limbic encephalitis has become an emerging diagnosis. The myriad symptoms of limbic encephalitis make the diagnosis challenging. Symptoms range from seizures, memory loss, dementia, confusion, to psychosis. We present a case of a 21-year-old female with GAD65 antibody-positive limbic encephalitis. The case is unique because the clinical course suggests that non-convulsive seizures are the major cause of this patient's clinical manifestations...
August 2016: Journal of Clinical Medicine Research
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