Yixin Ji, Godfrey Pearlson, Juan Bustillo, Peter Kochunov, Jessica A Turner, Rongtao Jiang, Wei Shao, Xiao Zhang, Zening Fu, Kaicheng Li, Zhaowen Liu, Xijia Xu, Daoqiang Zhang, Shile Qi, Vince D Calhoun
BACKGROUND: Similarities among schizophrenia (SZ), schizoaffective disorder (SAD) and bipolar disorder (BP) including clinical phenotypes, brain alterations and risk genes, make it challenging to perform reliable separation among them. However, previous subtype identification that transcend traditional diagnostic boundaries were based on group-level neuroimaging features, ignoring individual-level inferences. METHODS: 455 psychoses (178 SZs, 134 SADs and 143 BPs), their first-degree relatives (N = 453) and healthy controls (HCs, N = 220) were collected from Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP I) consortium...
December 20, 2023: Schizophrenia Research