keyword
https://read.qxmd.com/read/38296154/effects-of-the-pam-of-mglur2-jnj-46356479-on-brain-apoptotic-protein-levels-in-a-mouse-model-of-schizophrenia
#21
JOURNAL ARTICLE
David Olivares-Berjaga, Albert Martínez-Pinteño, Natalia Rodríguez, Santiago Madero, Llucía Prohens, Irene Martínez-Serrano, Sergi Mas, Constanza Morén, Eduard Parellada, Patricia Gassó
Current treatment for schizophrenia (SZ) ameliorates the positive symptoms, but is inefficient in treating the negative and cognitive symptoms. The SZ glutamatergic dysfunction hypothesis has opened new avenues in the development of novel drugs targeting the glutamate storm, an inducer of progressive neuropathological changes. Positive allosteric modulators of metabotropic glutamate receptor 2 (mGluR2), such as JNJ-46356479 (JNJ), reduce the presynaptic release of glutamate, which has previously been demonstrated to attenuate glutamate- and dopamine-induced apoptosis in human neuroblastoma cell cultures...
January 29, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38282757/antipsychotic-effect-of-diosgenin-in-ketamine-induced-murine-model-of-schizophrenia-involvement-of-oxidative-stress-and-cholinergic-transmission
#22
JOURNAL ARTICLE
Benneth Ben-Azu, Olusegun G Adebayo, Aliance Romain Fokoua, Benjamin Oritsemuelebi, Emmanuel O Chidebe, Chukwuebuka B Nwogueze, Lenatababari Kumanwee, God'swill E Uyere, Micheal T Emuakpeje
A decrease in the levels of antioxidant arsenals exacerbate generation of reactive oxygen/nitrogen species, leading to neurochemical dysfunction, with significant impact on the pathogenesis of psychotic disorders such as schizophrenia. This study examined the preventive and reversal effects of diosgenin, a phyto-steroidal saponin with antioxidant functions in mice treated with ketamine which closely replicates schizophrenia-like symptoms in human and laboratory animals. In the preventive phase, adult mice cohorts were clustered into 5 groups ( n  = 9)...
June 2024: IBRO neuroscience reports
https://read.qxmd.com/read/38268043/effect-of-immersive-virtual-reality-based-cognitive-remediation-in-patients-with-mood-or-psychosis-spectrum-disorders-study-protocol-for-a-randomized-controlled-double-blinded-trial
#23
JOURNAL ARTICLE
Andreas E Jespersen, Anders Lumbye, Maj Vinberg, Louise Glenthøj, Merete Nordentoft, Eva E Wæhrens, Gitte M Knudsen, Guido Makransky, Kamilla W Miskowiak
BACKGROUND: Cognitive impairments are prevalent across mood disorders and psychosis spectrum disorders, but there is a lack of real-life-like cognitive training programmes. Fully immersive virtual reality has the potential to ensure motivating and engaging cognitive training directly relevant to patients' daily lives. We will examine the effect of a 4-week, intensive virtual reality-based cognitive remediation programme involving daily life challenges on cognition and daily life functioning in patients with mood disorders or psychosis spectrum disorders and explore the neuronal underpinnings of potential treatment efficacy...
January 24, 2024: Trials
https://read.qxmd.com/read/38266908/proteomic-characteristics-of-the-prefrontal-cortex-and-hippocampus-in-mice-with-chronic-ketamine-induced-anxiety-and-cognitive-impairment
#24
JOURNAL ARTICLE
Li Xiao, Ying Wei, Hong Yang, Weihao Fan, Linzhi Jiang, Yi Ye, Yongping Qin, Xia Wang, Chunling Ma, Linchuan Liao
Schizophrenia, a complex psychiatric disorder with diverse symptoms, has been linked to ketamine, known for its N-methyl-D-aspartate (NMDA) receptor antagonistic properties. Understanding the distinct roles and mechanisms of ketamine is crucial, especially regarding its induction of schizophrenia-like symptoms. Recent research highlights the impact of ketamine on key brain regions associated with schizophrenia, specifically the prefrontal cortex (PFC) and hippocampus (Hip). This study focused on these regions to explore proteomic changes related to anxiety and cognitive impairment in a chronic ketamine-induced mouse model of schizophrenia...
January 22, 2024: Neuroscience
https://read.qxmd.com/read/38256020/the-association-of-hippocampal-long-term-potentiation-induced-gene-expression-with-genetic-risk-for-psychosis
#25
JOURNAL ARTICLE
Natalie L Wellard, Nicholas E Clifton, Elliott Rees, Kerrie L Thomas, Jeremy Hall
Genomic studies focusing on the contribution of common and rare genetic variants of schizophrenia and bipolar disorder support the view that substantial risk is conferred through molecular pathways involved in synaptic plasticity in the neurons of cortical and subcortical brain regions, including the hippocampus. Synaptic long-term potentiation (LTP) is central to associative learning and memory and depends on a pattern of gene expression in response to neuronal stimulation. Genes related to the induction of LTP have been associated with psychiatric genetic risk, but the specific cell types and timepoints responsible for the association are unknown...
January 12, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38255234/next-generation-proteomics-of-brain-extracellular-vesicles-in-schizophrenia-provide-new-clues-on-the-altered-molecular-connectome
#26
JOURNAL ARTICLE
Cristina Lorca, María Fernández-Rhodes, Jose Antonio Sánchez Milán, María Mulet, Félix Elortza, Alfredo Ramos-Miguel, Luis F Callado, J Javier Meana, Maria Mur, Iolanda Batalla, Elisabet Vilella, Aida Serra, Xavier Gallart-Palau
Extracellular vesicles (EVs) are tiny membranous structures that mediate intercellular communication. The role(s) of these vesicles have been widely investigated in the context of neurological diseases; however, their potential implications in the neuropathology subjacent to human psychiatric disorders remain mostly unknown. Here, by using next-generation discovery-driven proteomics, we investigate the potential role(s) of brain EVs (bEVs) in schizophrenia (SZ) by analyzing these vesicles from the three post-mortem anatomical brain regions: the prefrontal cortex (PFC), hippocampus (HC), and caudate (CAU)...
January 8, 2024: Biomedicines
https://read.qxmd.com/read/38246289/maternal-quercetin-supplementation-improved-lipopolysaccharide-induced-cognitive-deficits-and-inflammatory-response-in-a-rat-model-of-maternal-immune-activation
#27
JOURNAL ARTICLE
Hossein Abbasi, Sina Ghavami-Kia, Nahid Davoodian, Najmeh Davoodian
BACKGROUND: There is strong evidence that prenatal infection during a specific period of brain development increases the risk of neurodevelopmental disorders, partly through immune-inflammatory pathways. This suggests that anti-inflammatory agents could prevent these disorders by targeting the maternal inflammatory response. In the present study, we used a rat model of maternal immune activation (MIA) to examine whether maternal quercetin (QE) supplementation can alleviate behavioral deficits and inflammatory mediators in the prefrontal cortex (PFC) and hippocampus of adult male offspring...
January 19, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38244260/cyclooxygenase-2-inhibition-affects-the-ratio-of-glun2a-glun2b-receptor-subunits-through-interaction-with-mglur5-in-the-mouse-brain
#28
JOURNAL ARTICLE
Katarzyna Stachowicz, Patrycja Pańczyszyn-Trzewik, Paulina Misztak, Szymon Rzeźniczek, Magdalena Sowa-Kućma
N-methyl-D-aspartic acid receptors (NMDARs) are the most studied receptors in mammalian brains. Their role in depression, cognition, schizophrenia, learning and memorization, Alzheimer's disease, and more is well documented. In the search for new drug candidates in depression, intensive studies have been conducted. Compounds that act by influencing NMDARs have been particularly intensively investigated following the success of ketamine in clinics. Unfortunately, the side effects associated with ketamine do not allow it to be useful in all cases...
January 17, 2024: Neuropeptides
https://read.qxmd.com/read/38236296/the-guanine-nucleotide-exchange-factor-rapgef2-is-required-for-erk-dependent-immediate-early-gene-egr1-activation-during-fear-memory-formation
#29
JOURNAL ARTICLE
Sunny Zhihong Jiang, Meishar Shahoha, Hai-Ying Zhang, William Brancaleone, Abdel Elkahloun, Hugo A Tejeda, Uri Ashery, Lee E Eiden
The MAP kinase ERK is important for neuronal plasticity underlying associative learning, yet specific molecular pathways for neuronal ERK activation are undetermined. RapGEF2 is a neuron-specific cAMP sensor that mediates ERK activation. We investigated whether it is required for cAMP-dependent ERK activation leading to other downstream neuronal signaling events occurring during associative learning, and if RapGEF2-dependent signaling impairments affect learned behavior. Camk2α-cre+/- ::RapGEF2fl/fl mice with depletion of RapGEF2 in hippocampus and amygdala exhibit impairments in context- and cue-dependent fear conditioning linked to corresponding impairment in Egr1 induction in these two brain regions...
January 18, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38226747/limbic-brain-subregions-associated-with-mental-health-symptoms-in-youth-with-and-without-prenatal-alcohol-exposure
#30
JOURNAL ARTICLE
Daphne Nakhid, Darpal Patel, Carly A McMorris, W Ben Gibbard, Christina Tortorelli, Jacqueline Pei, Catherine Lebel
BACKGROUND: Prenatal alcohol exposure (PAE) can result in reduced brain volume and an increased risk of mental health challenges. Limbic brain structures such as the hippocampus, thalamus, and amygdala often exhibit smaller volumes in youth with PAE, and similar volume reductions are observed in unexposed youth with symptoms of depression, bipolar disorder, anxiety, and schizophrenia. However, the role of volume reductions in these brain regions in mental health challenges remains unclear for individuals with PAE...
November 2023: Alcohol Clin Exp Res (Hoboken)
https://read.qxmd.com/read/38198858/gene-expression-imputation-provides-clinical-and-biological-insights-into-treatment-resistant-schizophrenia-polygenic-risk
#31
JOURNAL ARTICLE
Llucia Prohens, Natalia Rodríguez, Àlex-Gonzàlez Segura, Albert Martínez-Pinteño, David Olivares-Berjaga, Irene Martínez, Aitor González, Gisela Mezquida, Mara Parellada, Manuel J Cuesta, Miquel Bernardo, Patricia Gassó, Sergi Mas
Genome-wide association studies (GWAS) have revealed the polygenic nature of treatment-resistant schizophrenia TRS. Gene expression imputation allowed the translation of GWAS results into regulatory mechanisms and the construction of gene expression (GReX) risk scores (GReX-RS).  In the present study we computed GReX-RS from the largest GWAS of TRS to assess its association with clinical features. We perform transcriptome imputation in the largest GWAS of TRS to find GReX associated with TRS using brain tissues...
January 5, 2024: Psychiatry Research
https://read.qxmd.com/read/38195548/d-cycloserine-enhances-the-bidirectional-range-of-nmdar-dependent-hippocampal-synaptic-plasticity
#32
JOURNAL ARTICLE
Stefan Vestring, Alexandra Dorner, Jonas Scholliers, Konstantin Ehrenberger, Andrea Kiss, Luis Arenz, Alice Theiss, Paul Rossner, Sibylle Frase, Catherine Du Vinage, Elisabeth Wendler, Tsvetan Serchov, Katharina Domschke, Josef Bischofberger, Claus Normann
The partial N-methyl-D-aspartate receptor (NMDAR) agonist D-Cycloserine (DCS) has been evaluated for the treatment of a wide variety of psychiatric disorders, including dementia, schizophrenia, depression and for the augmentation of exposure-based psychotherapy. Most if not all of the potential psychiatric applications of DCS target an enhancement or restitution of cognitive functions, learning and memory. Their molecular correlate is long-term synaptic plasticity; and many forms of synaptic plasticity depend on the activation of NMDA receptors...
January 9, 2024: Translational Psychiatry
https://read.qxmd.com/read/38160852/unraveling-the-role-of-slc10a4-in-auditory-processing-and-sensory-motor-gating-implications-for-neuropsychiatric-disorders
#33
JOURNAL ARTICLE
Barbara Ciralli, Thawann Malfatti, Markus M Hilscher, Richardson N Leao, Christopher R Cederroth, Katarina E Leao, Klas Kullander
BACKGROUND: Psychiatric disorders, such as schizophrenia, are complex and challenging to study, partly due to the lack of suitable animal models. However, the absence of the Slc10a4 gene, which codes for a monoaminergic and cholinergic associated vesicular transporter protein, in knockout mice (Slc10a4-/- ), leads to the accumulation of extracellular dopamine. A major challenge for studying schizophrenia is the lack of suitable animal models that accurately represent the disorder. We sought to overcome this challenge by using Slc10a4-/- mice as a potential model, considering their altered dopamine levels...
December 29, 2023: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38157113/differential-effects-of-neonatal-ventral-hippocampus-lesion-on-behavior-and-corticolimbic-plasticity-in-wistar-kyoto-and-spontaneously-hypertensive-rats
#34
JOURNAL ARTICLE
Hiram Tendilla-Beltrán, Linda Garcés-Ramírez, Edwin Martínez-Vásquez, Andrea Nakakawa, Ma de Jesús Gómez-Villalobos, Gonzalo Flores
Dysfunction of the corticolimbic system, particularly at the dendritic spine level, is a recognized core mechanism in neurodevelopmental disorders such as schizophrenia. Neonatal ventral hippocampus lesion (NVHL) in Sprague-Dawley rats induces both a schizophrenia-related behavioral phenotype and dendritic spine pathology (reduced total number and mature spines) in corticolimbic areas, which is mitigated by antipsychotics. However, there is limited information on the impact of rat strain on NVHL outcomes and antipsychotic effects...
December 29, 2023: Neurochemical Research
https://read.qxmd.com/read/38154608/defects-in-ampar-trafficking-and-microglia-activation-underlie-socio-cognitive-deficits-associated-to-decreased-expression-of-phosphodiesterase-2%C3%A2-a
#35
JOURNAL ARTICLE
Sébastien Delhaye, Marielle Jarjat, Asma Boulksibat, Clara Sanchez, Alessandra Tempio, Andrei Turtoi, Mauro Giorgi, Sandra Lacas-Gervais, Gabriele Baj, Carole Rovere, Viviana Trezza, Manuela Pellegrini, Thomas Maurin, Enzo Lalli, Barbara Bardoni
Phosphodiesterase 2 A (PDE2A) is an enzyme involved in the homeostasis of cAMP and cGMP and is the most highly expressed PDE in human brain regions critical for socio-cognitive behavior. In cerebral cortex and hippocampus, PDE2A expression level is upregulated in Fmr1-KO mice, a model of the Fragile X Syndrome (FXS), the most common form of inherited intellectual disability (ID) and autism spectrum disorder (ASD). Indeed, PDE2A translation is negatively modulated by FMRP, whose functional absence causes FXS...
December 26, 2023: Neurobiology of Disease
https://read.qxmd.com/read/38128344/identifying-psychosis-subtypes-use-individualized-covariance-structural-differential-networks-and-multi-site-clustering
#36
JOURNAL ARTICLE
Yixin Ji, Godfrey Pearlson, Juan Bustillo, Peter Kochunov, Jessica A Turner, Rongtao Jiang, Wei Shao, Xiao Zhang, Zening Fu, Kaicheng Li, Zhaowen Liu, Xijia Xu, Daoqiang Zhang, Shile Qi, Vince D Calhoun
BACKGROUND: Similarities among schizophrenia (SZ), schizoaffective disorder (SAD) and bipolar disorder (BP) including clinical phenotypes, brain alterations and risk genes, make it challenging to perform reliable separation among them. However, previous subtype identification that transcend traditional diagnostic boundaries were based on group-level neuroimaging features, ignoring individual-level inferences. METHODS: 455 psychoses (178 SZs, 134 SADs and 143 BPs), their first-degree relatives (N = 453) and healthy controls (HCs, N = 220) were collected from Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP I) consortium...
December 20, 2023: Schizophrenia Research
https://read.qxmd.com/read/38127959/social-isolation-induced-transcriptomic-changes-in-mouse-hippocampus-impact-the-synapse-and-show-convergence-with-human-genetic-risk-for-neurodevelopmental-phenotypes
#37
JOURNAL ARTICLE
Aodán Laighneach, John P Kelly, Lieve Desbonnet, Laurena Holleran, Daniel M Kerr, Declan McKernan, Gary Donohoe, Derek W Morris
Early life stress (ELS) can impact brain development and is a risk factor for neurodevelopmental disorders such as schizophrenia. Post-weaning social isolation (SI) is used to model ELS in animals, using isolation stress to disrupt a normal developmental trajectory. We aimed to investigate how SI affects the expression of genes in mouse hippocampus and to investigate how these changes related to the genetic basis of neurodevelopmental phenotypes. BL/6J mice were exposed to post-weaning SI (PD21-25) or treated as group-housed controls (n = 7-8 per group)...
2023: PloS One
https://read.qxmd.com/read/38123893/impaired-reversal-learning-in-the-dlg2-rat-model-of-genetic-risk-for-psychiatric-disorder-important-questions-regarding-the-neuro-behavioral-mechanisms-of-reversal-learning
#38
JOURNAL ARTICLE
Tobias Bast, Rachel Grasmeder Allen, Silvia Maggi, Jacco Renstrom
In this issue, Griesius et al report that heterozygous Dlg2+/- rats showed a reversal learning impairment on a specific bowl-digging task, whereas other reversal tasks were unaffected. The study suggests that Dlg2 gene disruption, which has been linked to neuropsychiatric disorders, including schizophrenia, may cause relatively specific impairments in reversal learning, an important aspect of cognitive flexibility. The study draws attention to two important issues regarding the neuro-behavioral mechanisms of reversal learning, namely that hippocampal dysfunction, which is prominent in Dlg2+/- rats, may contribute to reversal learning impairments and that, depending on the task and previous experience, brain and behavioral mechanisms of reversal learning may differ...
December 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/38122862/the-role-of-sirt3-in-mediating-the-cognitive-deficits-and-neuroinflammatory-changes-associated-with-a-developmental-animal-model-of-schizophrenia
#39
JOURNAL ARTICLE
Keke Hao, Fashuai Chen, Shilin Xu, Ying Xiong, Rui Xu, Huan Huang, Chang Shu, Huiling Wang, Gaohua Wang, Gavin P Reynolds
The neuroinflammatory state may contribute to the pathogenesis of many mental disorders including schizophrenia. Nicotinamide adenine dinucleotide (NAD+ ) is an essential cofactor for activation of proteins involved in mitochondria quality control, such as Sirtuin3 (SIRT3). Our previous study has found that NAD+ supplement could rescue early life stress (ELS)-induced neuroinflammation and down-regulation of SIRT3 in adult offspring. However, it is unclear whether SIRT3 is the key to the neuroprotective effects of NAD+ supplement in this animal model of schizophrenia...
December 18, 2023: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38110609/taar1-agonist-ulotaront-modulates-striatal-and-hippocampal-glutamate-function-in-a-state-dependent-manner
#40
JOURNAL ARTICLE
Sung M Yang, Ayan Ghoshal, Jeffrey M Hubbard, Florian Gackière, Romain Teyssié, Stuart A Neale, Seth C Hopkins, Kenneth S Koblan, Linda J Bristow, Nina Dedic
Aberrant dopaminergic and glutamatergic function, particularly within the striatum and hippocampus, has repeatedly been associated with the pathophysiology of schizophrenia. Supported by preclinical and recent clinical data, trace amine-associated receptor 1 (TAAR1) agonism has emerged as a potential new treatment approach for schizophrenia. While current evidence implicates TAAR1-mediated regulation of dopaminergic tone as the primary circuit mechanism, little is known about the effects of TAAR1 agonists on the glutamatergic system and excitation-inhibition balance...
December 19, 2023: Neuropsychopharmacology
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