Edita Bulovaite, Zhen Qiu, Maximilian Kratschke, Adrianna Zgraj, David G Fricker, Eleanor J Tuck, Ragini Gokhale, Babis Koniaris, Shekib A Jami, Paula Merino-Serrais, Elodie Husi, Lorena Mendive-Tapia, Marc Vendrell, Thomas J O'Dell, Javier DeFelipe, Noboru H Komiyama, Anthony Holtmaat, Erik Fransén, Seth G N Grant
The lifetime of proteins in synapses is important for their signaling, maintenance, and remodeling, and for memory duration. We quantified the lifetime of endogenous PSD95, an abundant postsynaptic protein in excitatory synapses, at single-synapse resolution across the mouse brain and lifespan, generating the Protein Lifetime Synaptome Atlas. Excitatory synapses have a wide range of PSD95 lifetimes extending from hours to several months, with distinct spatial distributions in dendrites, neurons, and brain regions...
December 21, 2022: Neuron