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https://www.readbyqxmd.com/read/28527666/hepatic-steatosis-progresses-faster-in-hiv-mono-infected-than-hiv-hcv-co-infected-patients-and-is-associated-with-liver-fibrosis
#1
Thomas Pembroke, Marc Deschenes, Bertrand Lebouché, Amine Benmassaoud, Maida Sewitch, Peter Ghali, Philip Wong, Alex Halme, Elise Vuille-Lessard, Costa Pexos, Marina B Klein, Giada Sebastiani
BACKGROUND & AIMS: Hepatic steatosis (HS) seems common in patients infected with human immunodeficiency virus (HIV). However, the relative effect of HIV, as well as hepatitis C virus (HCV) in those co-infected, and the influence of HS on liver fibrosis progression are unclear. METHODS: The LIVEr disease in HIV (LIVEHIV) is a Canadian prospective Cohort using transient elastography and associated controlled attenuation parameter (CAP) to screen for HS and liver fibrosis in unselected HIV-infected adults...
May 17, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28523305/the-impact-of-liver-steatosis-on-early-and-sustained-treatment-response-in-chronic-hepatitis-c-patients
#2
Alice Elena Găman, Anca Marilena Ungureanu, Adriana Turculeanu, Dan IonuŢ Gheonea, Andrei Ioan Drocaş, George Mitroi, Maria DobriŢoiu, Maria Victoria Comănescu, Andreea Doriana Stănculescu, Ramona Cioboată, Claudiu Florin Jieanu, Paul Ioan Tomescu
Steatosis is a frequent feature of hepatitis C virus (HCV) infection. Steatosis may be an important cofactor in both accelerating fibrosis and increasing liver necroinflammatory activity in chronic hepatitis C. The main objective of this study was the evaluation of biological response rates, early viral response, sustained viral response in patients with chronic hepatitis C treated with Interferon-alpha (IFN-α), Pegylated (PEG)-IFN-α2a or -α2b plus Ribavirin and to relate it to the presence of hepatic steatosis...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28513591/zinc-is-a-potent-and-specific-inhibitor-of-ifn-%C3%AE-3-signalling
#3
Scott A Read, Kate S O'Connor, Vijay Suppiah, Chantelle L E Ahlenstiel, Stephanie Obeid, Kristina M Cook, Anthony Cunningham, Mark W Douglas, Philip J Hogg, David Booth, Jacob George, Golo Ahlenstiel
Lambda interferons (IFNL, IFN-λ) are pro-inflammatory cytokines important in acute and chronic viral infection. Single-nucleotide polymorphisms rs12979860 and rs8099917 within the IFNL gene locus predict hepatitis C virus (HCV) clearance, as well as inflammation and fibrosis progression in viral and non-viral liver disease. The underlying mechanism, however, is not defined. Here we show that the rs12979860 CC genotype correlates with increased hepatic metallothionein expression through increased systemic zinc levels...
May 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28507926/decrease-of-alpha-fetoprotein-in-patients-with-cirrhosis-treated-with-direct-acting-antivirals
#4
Kelvin Nguyen, Melissa Jimenez, Nima Moghadam, Crystal Wu, Alex Farid, Jonathan Grotts, David Elashoff, Gina Choi, Francisco A Durazo, Mohamed M El-Kabany, Steven-Huy B Han, Sammy Saab
Background and Aims: The lack of specificity has limited the role of serum alpha-fetoprotein (AFP) for hepatocellular carcinoma (HCC) screening among patients with cirrhosis related to hepatitis C virus (HCV) infection. We sought to examine whether AFP may decrease after achieving a sustained virological response (SVR) in patients with HCV-related cirrhosis. Methods: We performed a retrospective study of patients with HCV-related cirrhosis who were cured with direct-acting antiviral (DAA) therapy at the University of California, Los Angeles...
March 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28507919/hepatitis-c-virus-rna-strands-detection-in-peripheral-blood-mononuclear-cells-legitimizes-virus-eradication-in-negative-serum-pcr-na%C3%A3-ve-and-post-treatment-patients
#5
Mohamed Darwish Ahmed Abd Alla, Mostafa Kamel El Awady
Background and Aims: Hepatitis C virus (HCV) hepatotropism is associated with intra-peripheral blood mononuclear cell (PBMC) infection that causes post-treatment relapse in RNA seronegative patients. Our understanding of the association of non-viremic hepatic fibrosis with positive anti-HCV IgG antibodies and active hepatocellular damage might be increased by PBMCs screening for intracellular infection. Thus, the goals of this study included evaluation of PBMCs PCR for diagnosing HCV infection, addressing PBMCs plus serum real-time (SRT) PCR benefits over SRT-PCR alone, studying intra-PBMCs distribution of RNA sense and antisense strands, and identifying treatment feasibility in solitary intracellular infection...
March 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28504002/development-and-evaluation-of-a-novel-score-for-prediction-of-large-oesophageal-varices-in-patients-with-hepatitis-c-virus-induced-liver-cirrhosis
#6
K Farid, M M Omran, R E Farag, M M Arafa, T M Emran
OBJECTIVE: Variceal bleeding is one of the most common life-threatening complications of liver cirrhosis. This study aimed to develop and evaluate a predictive score, named Platelet count, Alpha fetoprotein (AFP) and Prothrombin-INR (PAP) for the prediction of large oesophageal varices and to compare PAP score with eight common liver fibrosis scores (AAR, APRI, GUCI, BRC score, Fibro-Alfa, FIB4, Lok and Fibro-Q) in patients with hepatitis C virus (HCV) induced liver cirrhosis. METHODS: A total of 277 patients with HCV-induced liver cirrhosis were evaluated by upper gastrointestinal endoscopy for presence of varices...
May 15, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28503671/hiv-hcv-co-infection-liver-disease-progression-and-age-related-igf-1-decline
#7
Jeffrey Quinn, Jacquie Astemborski, Shruti H Mehta, Gregory D Kirk, David L Thomas, Ashwin Balagopal
BACKGROUND: We have previously reported that persons co-infected with HIV and hepatitis C virus (HCV) had liver disease stages similar to HIV-uninfected individuals who were approximately 10 years older. Insulin-like growth factor 1(IGF-1) levels have long been known to decline with advancing age in humans and non-humans alike. We examined whether HIV infection affects the expected decline in IGF-1 in persons with chronic hepatitis C virus (HCV) infection and if that alteration in IGF-1 decline contributes to the link between HIV, aging, and liver disease progression...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28501538/biopsies-from-allograft-liver-contain-histologic-features-of-hepatitis-c-virus-infection-following-virus-eradication
#8
Emma Whitcomb, Won-Tak Choi, Keith R Jerome, Linda Cook, Charles Landis, Joseph Ahn, Helen S Te, Jamak Esfeh, Ibrahim A Hanouneh, Stephen C Rayhill, William Gibson, Thomas Plesec, Jamie Koo, Hanlin L Wang, John Hart, Rish K Pai, Maria Westerhoff
BACKGROUND & AIMS: Most patients, even those who have received liver transplants, achieve a sustained virologic response (SVR) to therapy for hepatitis C virus (HCV) infection. Little is known about the histologic features of liver biopsies collected following SVR, particularly in patients who have received liver transplants. We aimed to better characterize the histologic features of allograft liver biopsies from patients who achieved a SVR to anti-HCV therapy following liver transplantation...
May 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28492391/hepatitis-c-virus-drives-increased-type-i-interferon-associated-impairments-associated-with-fibrosis-severity-in-antiretroviral-treatment-treated-hiv-1-hepatitis-c-virus-coinfected-individuals
#9
Morgane Griesbeck, Marc-Antoine Valantin, Karine Lacombe, Assia Samri-Hassimi, Julie Bottero, Catherine Blanc, Zineb Sbihi, Rima Zoorob, Christine Katlama, Marguerite Guiguet, Marcus Altfeld, Brigitte Autran
BACKGROUND: Viral coinfections might contribute to the increased immune activation and inflammation that persist in antiretroviral treatment (ART)-treated HIV-1 patients. We investigated whether the hepatitis C virus (HCV) coinfection contributes to such alterations by impairing the plasmacytoid dendritic cell (pDC) IFNα/TLR7 pathway in a highly homogeneous group of ART-treated HIV-1-HCV-coinfected patients. METHODS: Twenty-nine HIV-1-infected patients with fully suppressive ART were included, 15 of whom being HCV-coinfected with mild-to-moderate fibrosis and matched for their HIV-1 disease, and 13 control healthy donors...
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28489307/non-alcoholic-fatty-liver-nafl-and-advanced-fibrosis-in-the-elderly-results-from-a-community-based-polish-survey
#10
Marek Hartleb, Kamil Barański, Jan Zejda, Jerzy Chudek, Andrzej Więcek
INTRODUCTION & AIM: Development of non-alcoholic fatty liver (NAFL) is dependent on metabolic factors occurring at an increased frequency with advancing age. Until now, few studies have explored the prevalence of NAFL in aged populations. Our study aimed to determine the prevalence of NAFL and advanced fibrosis in the elderly population participating in a national survey of a community-based elderly cohort. METHODS: A total of 3003 participants (mean age 79.6 years, 46...
May 10, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28487083/hcv-clearance-after-direct-acting-antivirals-in-patients-with-cirrhosis-by-stages-of-liver-impairment-the-ital-c-network-study
#11
Antonio Massimo Ippolito, Michele Milella, Vincenzo Messina, Fabio Conti, Raffaele Cozzolongo, Filomena Morisco, Giuseppina Brancaccio, Michele Barone, Teresa Santantonio, Chiara Masetti, Paolo Tundo, Antonina Smedile, Vito Carretta, Pietro Gatti, Antonio Patrizio Termite, Maria Rosa Valvano, Giuseppe Bruno, Claudia Fabrizio, Pietro Andreone, Marianna Zappimbulso, Giovanni Battista Gaeta, Nicola Napoli, Luca Fontanella, Gianfranco Lauletta, Giuseppe Cuccorese, Antonio Metrangolo, Ruggiero Francavilla, Emanuela Ciracì, Salvatore Rizzo, Angelo Andriulli
BACKGROUND: Sustained virological response (SVR12) rates at 12 weeks after treatment for HCV-infected patients with decompensated cirrhosis are used when referring to those with moderate functional impairment, while few data are available for those with more severe impairment. The use of the cirrhosis staging system proposed by D'Amico might provide new insights on timing for antiviral therapy. METHODS: We investigated efficacy (SVR12), safety, and post-treatment variations in clinical and laboratory parameters in 2612 patients with advanced fibrosis (n=575) or cirrhosis (n=2037)...
April 8, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28484111/liver-fibrosis-after-antiretroviral-therapy-in-a-longitudinal-cohort-of-sexually-infected-hiv-patients-in-eastern-china
#12
Qian Wei, Haijiang Lin, Yingying Ding, Xing Liu, Qionghai Wu, Weiwei Shen, Meiyang Gao, Na He
We assessed the factors that influenced improvement or progression in human immunodeficiency virus (HIV)-infected patients who were receiving combination antiretroviral therapy (cART). This was a retrospective cohort study of HIV-infected patients receiving cART in Taizhou, Zhejiang, China, 2009-2015. Liver fibrosis was assessed by Fibrosis-4 (FIB-4) score. Improvement of liver fibrosis was defined as having > 30% decrease in FIB-4 from baseline, whereas progression of liver fibrosis was defined as having > 30% increase in FIB-4 score from baseline...
May 6, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28481325/impaired-platelet-aggregation-and-rebalanced-hemostasis-in-patients-with-chronic-hepatitis-c-virus-infection
#13
Nick S Nielsen, Sofie Jespersen, Julie C Gaardbo, Caroline J Arnbjerg, Mette R Clausen, Mette Kjær, Jan Gerstoft, Vibe Ballegaard, Sisse R Ostrowski, Susanne D Nielsen
Increased risk of both cardiovascular disease (CVD) and bleeding has been found in patients with chronic hepatitis C (CHC) infection, and a re-balanced hemostasis has been proposed. The aim of this study was to investigate functional whole blood coagulation and platelet function in CHC infection. The prospective study included 82 patients with CHC infection (39 with advanced liver fibrosis and 43 with no or mild liver fibrosis) and 39 healthy controls. A total of 33 patients were treated for CHC infection and achieved sustained virological response (SVR)...
May 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28480856/comparative-study-of-fib-4-index-and-transient-elastography-among-patients-with-chronic-hepatitis-c-virus-infection-in-georgia
#14
E Dolmazashvili, M Karchava, A Abutidze, L Sharvadze, T Tsertsvadze
Liver biopsy remains the reference standard for fibrosis staging. However, it has several limitations, which have led to the development of non-invasive methods. We evaluated liver fibrosis severity among HCV infected patients by comparing transient elastography (TE) and FIB-4 index. Retrospective study was conducted. Clinical data for 750 patients were obtained. The mean age of the study population was 51 years; 595 (79.3%) were male and 155 (20.7%) were female. TE and tests on biological samples were performed within one-week timeframe...
March 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28480681/the-role-of-liver-segment-to-spleen-volume-ratio-in-the-staging-of-hepatic-fibrosis-in-patients-with-hepatitis-c-virus-infection
#15
Eyal Lotan, Stephen P Raskin, Michal M Amitai, Yeruham Kleinbaum, Ella Veitsman, Peretz Weiss, Oranit Cohen-Ezra, Tania Berdichevski, Ziv Ben-Ari
BACKGROUND: Accurate assessment of liver fibrosis is crucial for the management of patients with hepatitis C virus (HCV) infection. OBJECTIVES: To evaluate the performance of liver segment-to-spleen volume ratio in predicting the severity of liver fibrosis. METHODS: Sixty-four consecutive HCV patients were enrolled in this retrospective study. All patients underwent contrast-enhanced computed tomography (CT) and were divided into three groups based on their hepatic fibrosis stage evaluated by shear-wave elastography (SWE): non-advanced (F0-F1, n=29), advanced (F2, n=19) and severe fibrosis (F3-F4, n=16)...
April 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28480293/barriers-to-hepatitis-c-virus-hcv-treatment-initiation-in-patients-with-human-immunodeficiency-virus-hcv-coinfection-lessons-from-the-interferon-era
#16
Tanyaporn Wansom, Oluwaseun Falade-Nwulia, Catherine G Sutcliffe, Shruti H Mehta, Richard D Moore, David L Thomas, Mark S Sulkowski
BACKGROUND: Hepatitis C is a major cause of mortality among human immunodeficiency virus (HIV)-infected patients, yet hepatitis C virus (HCV) treatment uptake has historically been low. Although the removal of interferon removes a major barrier to HCV treatment uptake, oral therapies alone may not fully eliminate barriers in this population. METHODS: Within the Johns Hopkins Hospital HIV cohort, a nested case-control study was conducted to identify cases, defined as patients initiating HCV treatment between January 1996 and 2013, and controls, which were selected using incidence density sampling (3:1 ratio)...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28480259/cost-effectiveness-and-cost-containment-in-the-era-of-interferon-free-therapies-to-treat-hepatitis-c-virus-genotype-1
#17
Benjamin P Linas, Jake R Morgan, Mai T Pho, Jared A Leff, Bruce R Schackman, C Robert Horsburgh, Sabrina A Assoumou, Joshua A Salomon, Milton C Weinstein, Kenneth A Freedberg, Arthur Y Kim
BACKGROUND: Interferon-free regimens to treat hepatitis C virus (HCV) genotype 1 are effective but costly. At this time, payers in the United States use strategies to control costs including (1) limiting treatment to those with advanced disease and (2) negotiating price discounts in exchange for exclusivity. METHODS: We used Monte Carlo simulation to investigate budgetary impact and cost effectiveness of these treatment policies and to identify strategies that balance access with cost control...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28480218/magnetic-resonance-elastography-shear-wave-velocity-correlates-with-liver-fibrosis-and-hepatic-venous-pressure-gradient-in-adults-with-advanced-liver-disease
#18
Ahmed M Gharib, Ma Ai Thanda Han, Eric G Meissner, David E Kleiner, Xiongce Zhao, Mary McLaughlin, Lindsay Matthews, Bisharah Rizvi, Khaled Z Abd-Elmoniem, Ralph Sinkus, Elliot Levy, Christopher Koh, Robert P Myers, G Mani Subramanian, Shyam Kottilil, Theo Heller, Joseph A Kovacs, Caryn G Morse
Background. Portal hypertension, an elevation in the hepatic venous pressure gradient (HVPG), can be used to monitor disease progression and response to therapy in cirrhosis. Since obtaining HVPG measurements is invasive, reliable noninvasive methods of assessing portal hypertension are needed. Methods. Noninvasive markers of fibrosis, including magnetic resonance elastography (MRE) shear wave velocity, were correlated with histologic fibrosis and HVPG measurements in hepatitis C (HCV) and/or HIV-infected patients with advanced liver disease enrolled in a clinical trial of treatment with simtuzumab, an anti-LOXL2 antibody...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28480063/viral-hepatitis-and-hepatocellular-carcinoma-etiology-and-management
#19
REVIEW
Philippe J Zamor, Andrew S deLemos, Mark W Russo
Chronic hepatitis B virus (HBV) and chronic hepatitis C virus (HCV) are associated with hepatic fibrosis and development of hepatocellular carcinoma (HCC). There are differences and variation with the incidence of HCC worldwide. Additionally, HCC develops via different pathways with these viral hepatitides. This review outlines the various mechanisms and pathophysiology that contributes to this process. There will also be a review on the recommended screening for HCC. Treatment considerations, which are different for these viruses, will be outlined in this review...
April 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28479504/magnitude-and-kinetics-of-decrease-in-liver-stiffness-after-anti-viral-therapy-in-patients-with-chronic-hepatitis-c-a-systematic-review-and-meta-analysis
#20
REVIEW
Siddharth Singh, Antonio Facciorusso, Rohit Loomba, Yngve T Falck-Ytter
BACKGROUND & AIMS: We performed a systematic review and meta-analysis to estimate the decrease in liver stiffness, measured by vibration-controlled transient elastrography (VCTE), in patients with hepatitis C virus (HCV) infection who achieved a sustained virologic response (SVR). METHODS: We searched the literature through October 2016 for observational studies or randomized controlled trials of adults with HCV infection who received antiviral therapy (either direct acting antiviral agents or interferon-based therapies), underwent liver stiffness measurement using VCTE before starting therapy, and had at least 1 follow-up VCTE after completion of therapy; studies also provided data on mean or median liver stiffness measurements for patients who did and did not achieve an SVR...
May 4, 2017: Clinical Gastroenterology and Hepatology
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