keyword
https://read.qxmd.com/read/38523384/local-control-and-toxicity-outcomes-following-consolidative-radiation-therapy-in-patients-with-high-risk-neuroblastoma-a-20-year-experience-at-a-single-center
#1
JOURNAL ARTICLE
Jeong Yun Jang, Jin-Hong Park, Yeon Joo Kim, Ho Joon Im, Kyung-Nam Koh, Hyery Kim, Sung Han Kang, Ha Un Kim, Seung Do Ahn
BACKGROUND: Intensive multimodal treatment can improve survival in patients with high-risk neuroblastoma, and consolidative radiation therapy has contributed to local control. We examined the clinical outcomes of patients who underwent consolidative radiation therapy at our institution. METHODS: We retrospectively reviewed the records of patients with high-risk neuroblastoma who underwent consolidative radiation therapy from March 2001 to March 2021 at Asan Medical Center...
2024: Turkish Journal of Pediatrics
https://read.qxmd.com/read/38522579/cystatin-c-outperforms-creatinine-in-predicting-cefepime-clearance-in-pediatric-stem-cell-transplant-recipients
#2
JOURNAL ARTICLE
H Rhodes Hambrick, Lin Fei, Kathryn Pavia, Jennifer Kaplan, Tomoyuki Mizuno, Peter Tang, Erin Schuler, Stefanie Benoit, Sonya Tang Girdwood
BACKGROUND: Pediatric hematopoietic stem cell transplant (HSCT) patients are at risk of developing both sepsis and altered kidney function. Cefepime is used for empiric coverage post-HSCT and requires dose adjustment based on kidney function. Since cefepime's anti-microbial efficacy is determined by the time free concentrations exceed bacterial minimum inhibitory concentration (MIC), it is important to assess kidney function accurately to ensure adequate concentrations. Serum creatinine (SCr) is routinely used to estimate glomerular filtration rate (eGFR) but varies with muscle mass, which can be significantly lower in HSCT patients, making SCr an inaccurate kidney function biomarker...
March 22, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38519267/successful-twin-delivery-through-in-vitro-fertilization-in-a-high-gestation-age-kidney-transplant-recipient-a-case-report
#3
JOURNAL ARTICLE
Chien Liu, Yi-Jung Li, Hsin-Hsu Wu, Hsien-Ming Wu, Ya-Chung Tian
BACKGROUND: Numerous successful pregnancy outcomes have been reported after kidney transplantation, but until now, there have been no reports of healthy twin deliveries through in vitro fertilization treatment in high-gestation aged women with a long post-transplant duration. In our report, we present a case of a high-gestation aged kidney transplant recipient who successfully delivered healthy twins with the aid of in vitro fertilization. CASE PRESENTATION: At the age of 29, a woman with end-stage kidney disease caused by immunoglobin A nephropathy underwent kidney transplantation...
March 21, 2024: Transplantation Proceedings
https://read.qxmd.com/read/38517399/surgical-treatment-of-secondary-hyperparathyroidism-in-children-with-chronic-kidney-disease-experience-in-19-patients
#4
JOURNAL ARTICLE
Silvia Mercedes Gil, Mariana Aziz, Valeria De Dona, Laura Lopez, Maria Florencia Soto, Victor Ayarzabal, Marta Adragna, Alicia Belgorosky, Marta Ciaccio, Gisela Viterbo
OBJECTIVES: Secondary hyperparathyroidism (sHPT) is an important contributor to bone disease and cardiovascular calcifications in children with chronic kidney disease (CKD). When conservative measures are ineffective, parathyroidectomy is indicated. The aim of our study was to evaluate the efficacy and safety of subtotal parathyroidectomy (sPTX) in pediatric and adolescent patients, and to provide a rationale for considering this aggressive treatment in CKD patients with uncontrolled sHPT...
March 25, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38512840/acute-kidney-injury-in-hospitalized-children-with-proteinuria-a-multicenter-retrospective-analysis
#5
JOURNAL ARTICLE
Katelyn H Baggett, Tomas Manghi, Vonn Walter, Neal J Thomas, Michael A Freeman, Conrad Krawiec
BACKGROUND AND OBJECTIVE: Acute kidney injury (AKI) is a common complication in hospitalized pediatric patients. Previous studies focused on adults found that proteinuria detected during an admission urinalysis is fit to serve as an indicator for AKI and associated clinical outcomes. The objective of this study is to evaluate if proteinuria on the first day of hospital services in hospitalized children is associated with AKI, need for renal replacement therapy, shock and/or antibiotic use, critical care services, and all-cause mortality at 30 days, hypothesizing that it is associated with these outcomes...
2024: PloS One
https://read.qxmd.com/read/38512380/association-of-mental-health-related-patient-reported-outcomes-with-blood-pressure-in-adults-and-children-with-primary-proteinuric-glomerulopathies
#6
JOURNAL ARTICLE
Matthew Schuchman, Tammy M Brady, Dorey A Glenn, Katherine R Tuttle, Gabriel Cara-Fuentes, Rebecca V Levy, Agustin Gonzalez-Vicente, Fadhl M Alakwaa, Tarak Srivastava, Christine B Sethna
INTRODUCTION: The prevalence of mental health disorders including anxiety and depression is increasing and is linked to hypertension in healthy individuals. However, the relationship of psychosocial patient-reported outcomes on blood pressure (BP) in primary proteinuric glomerulopathies is not well characterized. This study explored longitudinal relationships between psychosocial patient-reported outcomes and BP status among individuals with proteinuric glomerulopathies. METHODS: An observational cohort study was performed using data from 745 adults and children enrolled in the Nephrotic Syndrome Study Network (NEPTUNE)...
March 21, 2024: Journal of Nephrology
https://read.qxmd.com/read/38509517/investigating-the-use-of-finerenone-in-children-with-chronic-kidney-disease-and-proteinuria-design-of-the-fiona-and-open-label-extension-studies
#7
RANDOMIZED CONTROLLED TRIAL
Franz Schaefer, Giovanni Montini, Hee Gyung Kang, Johan Vande Walle, Joshua Zaritsky, Michiel F Schreuder, Mieczyslaw Litwin, Andrea Scalise, Helen Scott, James Potts, Pablo Iveli, Stefanie Breitenstein, Bradley A Warady
INTRODUCTION: Proteinuria is a modifiable risk factor for chronic kidney disease (CKD) progression in children. Finerenone, a selective, non-steroidal, mineralocorticoid receptor antagonist (MRA) has been approved to treat adults with CKD associated with type 2 diabetes mellitus (T2DM) following results from the phase III clinical trials FIDELIO-DKD (NCT02540993) and FIGARO-DKD (NCT02545049). In a pre-specified pooled analysis of both studies (N = 13,026), finerenone was shown to have an acceptable safety profile and was efficacious in decreasing the risk of adverse kidney and cardiovascular outcomes and of proteinuria...
March 21, 2024: Trials
https://read.qxmd.com/read/38506236/resurgence-of-human-respiratory-syncytial-virus-during-covid-19-pandemic-in-southern-brazil
#8
JOURNAL ARTICLE
Guilherme C Fröhlich, Tatiana S Gregianini, Felipe G Pinheiro, Rodrigo Nascimento, Thiago M Cezar, Veridiane M Pscheidt, Tainá Selayaran, Letícia G Martins, Marcelo Ferreira da Costa Gomes, Richard S Salvato, Elisa C Pereira, Victor Guimarães-Ribeiro, Letícia de Paula Scalioni, Marilda M Siqueira, Paola C Resende, Ana B G Veiga
Respiratory Syncytial Virus (RSV) is an important cause of respiratory infection in humans. Severe cases are common in children ≤2 years old, immunocompromised individuals, and the elderly. In 2020, RSV infection reduced in Rio Grande do Sul (RS), southern Brazil; however, in 2021 resurgence of RSV was observed. This study analyzed epidemiological and genetic features of RSV infection cases reported in 2021 in RS. Nasopharyngeal samples collected from individuals with respiratory infection negative for SARS-CoV-2, Influenza A and B viruses were assessed for the presence of RSV by real time RT-qPCR...
March 2024: Journal of Medical Virology
https://read.qxmd.com/read/38504636/prevention-of-dialysis-disequilibrium-syndrome-in-children-with-advanced-uremia-with-a-structured-hemodialysis-protocol-a-quality-improvement-initiative-study
#9
JOURNAL ARTICLE
Sidharth Kumar Sethi, Valerie Luyckx, Timothy Bunchman, Aishwarya Nair, Shyam Bihari Bansal, Bryce Pember, Kritika Soni, Savita, Dinesh Kumar Yadav, Vivek Sharma, Khalid Alhasan, Rupesh Raina
BACKGROUND: Dialysis disequilibrium syndrome (DDS) is a rare but significant concern in adult and pediatric patients undergoing dialysis initiation with advanced uremia or if done after an interval. It is imperative to gain insights into the epidemiological patterns, pathophysiological mechanisms, and preventive strategies aimed at averting the onset of this ailment. DESIGN: Prospective observational quality improvement initiative cohort study. SETTING AND PARTICIPANTS: A prospective single-center study involving 50 pediatric patients under 18 years recently diagnosed with chronic kidney disease stage V with blood urea ≥200 mg/dL, admitted to our tertiary care center for dialysis initiation from January 2017 to October 2023...
March 20, 2024: Hemodialysis International
https://read.qxmd.com/read/38503990/use-of-activity-trackers-to-improve-blood-pressure-in-young-people-at-risk-for-cardiovascular-disease-a-pilot-randomized-controlled-trial
#10
JOURNAL ARTICLE
Alexandra C Bicki, Divya Seth, Charles E McCulloch, Feng Lin, Elaine Ku
BACKGROUND: Promoting physical activity among young individuals with cardiovascular disease (CVD) risk factors such as hypertension, diabetes, or chronic kidney disease can lower systolic blood pressure (BP). We sought to determine whether a 6-month intervention using a physical activity tracker was feasible and effective, compared with usual care. METHODS: Participants were recruited at a single academic medical center. Those aged 8-30 years were randomized in a 2:1 ratio to either the intervention (use of a Fitbit physical activity tracker coupled with feedback regarding the participant's step count) or usual care...
March 19, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38502224/gastrostomy-feeding-in-children-with-chronic-kidney-disease-comes-of-age
#11
EDITORIAL
Sarah E Ledermann
No abstract text is available yet for this article.
March 19, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38496155/profile-of-acute-kidney-injury-in-the-pediatric-age-group-in-a-tertiary-care-hospital-a-prospective-observational-study
#12
JOURNAL ARTICLE
Ishan Kapil, Anil Kumar Goel, Manas R Sahoo
BACKGROUND AND OBJECTIVES: Acute kidney injury (AKI) is a menace in the pediatric intensive care unit (PICU) and is responsible for significant morbidity and mortality all over the world. There are limited data available on pediatric AKI in central India. Our primary objective is to determine the clinical, etiological, and outcome profile of AKI in the pediatric age group of 3 months to 15 years admitted to the All India Institute of Medical Sciences (AIIMS), Raipur. The secondary objective(s) is to predict the association of mortality in children diagnosed with AKI and to estimate the number of patients developing chronic kidney disease (CKD) at three-month follow-up...
February 2024: Curēus
https://read.qxmd.com/read/38490657/human-umbilical-cord-mesenchymal-stem-cell-therapy-for-renal-dysfunction-in-alport-syndrome-protocol-for-an-open-label-single-arm-trial-in-china
#13
JOURNAL ARTICLE
Li Huang, Jun Zou, Yuxin Zhang, Jiaowei Gu, Jianlong Wu, Che Zhang
INTRODUCTION: Alport syndrome (AS) is one of the most common fatal hereditary renal diseases in human, with a high risk of progressing to end-stage renal disease without effective treatments. Mesenchymal stem cells (MSCs) have recently emerged as a promising therapeutic strategy for chronic kidney disease. However, the safety and therapeutic potential of MSC transfusion for patients with AS are still need to be confirmed. Therefore, we have designed a clinical trial to evaluate the hypothesis that intravenous infusion of human umbilical cord-derived MSC (hUC-MSC) is safe, feasible, and well-tolerated in children with AS...
March 15, 2024: BMJ Open
https://read.qxmd.com/read/38488898/evaluation-of-egfr-methods-in-a-sub-saharan-african-community-based-pediatric-population
#14
JOURNAL ARTICLE
Michael Abel Alao, Olayinka Rasheed Ibrahim, Adanze Onyenonachi Asinobi, Debo Adebowale Ademola, Udeme Ekpenyong Ekrikpo, Wasiu Adekunle Olowu
BACKGROUND: Accurate assessment of the estimated glomerular filtration rate (eGFR) plays a pivotal role in the early detection, management, and optimal medication dosing for chronic kidney disease (CKD). However, validation of eGFR, utilizing cystatin C-based equations, is limited in African children and adolescents with CKD. We evaluate the agreement of eGFR equations incorporating both cystatin C and creatinine in this specific population. METHODS: This community-based study assessed CKD in children (2-15 years) using cystatin C and serum creatinine...
March 15, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38488435/identification-of-novel-pathogenic-variants-of-cubn-in-patients-with-isolated-proteinuria
#15
JOURNAL ARTICLE
Huihui Yang, Lanfen He, Hongjian Gong, Chunhui Wan, Juanjuan Ding, Panli Liao, Xiaowen Wang
BACKGROUND: Although proteinuria is long recognized as an independent risk factor for progressive chronic kidney diseases, not all forms of proteinuria are detrimental to kidney function, one of which is isolated proteinuria caused by cubilin (CUBN)-specific mutations. CUBN encodes an endocytic receptor, initially found to be responsible for the Imerslund-Gräsbeck syndrome (IGS; OMIM #261100) characterized by a combined phenotype of megaloblastic anemia and proteinuria. METHODS: After analyzing their clinical and pathological characterizations, next-generation sequencing for renal disease genes or whole-exome sequencing (WES) was performed on four patients with non-progressive isolated proteinuria...
March 2024: Molecular Genetics & Genomic Medicine
https://read.qxmd.com/read/38487751/zinc-supplementation-trial-in-pediatric-chronic-kidney-disease-effects-on-circulating-fgf-23-and-klotho
#16
JOURNAL ARTICLE
V Belostotsky, S A Atkinson, G Filler
BACKGROUND: Zinc status, its role in bone metabolism and efficacy of deficiency correction has not been well studied in children with chronic kidney disease (CKD). OBJECTIVES: The primary objective was to investigate whether 3 months of oral zinc supplementation corrects zinc deficiency in children with CKD who have native or transplanted kidneys. The secondary objective was to compare circulating intact FGF-23 (iFGF-23), c-terminal FGF-23 (cFGF-23), and Klotho between zinc-sufficient and zinc-deficient children with CKD and to assess the relationship between circulating zinc, iFGF-23, cFGF-23, Klotho, bone biomarkers, copper, and phosphate excretion pre-supplementation and post-supplementation of zinc...
2024: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/38485661/-it-was-classed-as-a-nonemergency-women-s-experiences-of-kidney-disease-and-preconception-decision-making-family-planning-and-parenting-in-the-united-kingdom-during-covid-19
#17
JOURNAL ARTICLE
Leah Mc Laughlin, Jane Noyes, Barbara Neukirchinger, Denitza Williams, Rhiannon Phillips, Sian Griffin
OBJECTIVES: To investigate the experiences of women with kidney disease, residing in the United Kingdom (UK), living through the first 18 months of the COVID-19 pandemic with specific focus on preconception decision-making, family planning, and parenting. METHODS: We conducted a mixed-methods study, comprising an online survey and follow-up interviews, with UK-resident women aged 18-50. RESULTS: We received 431 surveys and conducted 30 interviews...
March 14, 2024: Perspectives on Sexual and Reproductive Health
https://read.qxmd.com/read/38485067/dietary-phosphate-educational-materials-for-pediatric-chronic-kidney-disease-are-confused-messages-reducing-their-impact
#18
JOURNAL ARTICLE
Louise McAlister, Vanessa Shaw, Rukshana Shroff
OBJECTIVE: This study aimed to review the quality and content of phosphate educational materials used in pediatric chronic kidney disease. METHODS: The quality of text-based pediatric phosphate educational materials was assessed using validated instruments for health literacy demands (Suitability Assessment of Materials [SAM] and Patient Education Material Assessment Tool [PEMAT-P]) and readability (Flesch Reading Ease [FRE] and Flesch-Kincaid [FK] Grade Level)...
March 12, 2024: Journal of Renal Nutrition
https://read.qxmd.com/read/38483608/nutritional-status-as-a-predictive-factor-for-paediatric-tuberous-sclerosis-complex-associated-kidney-angiomyolipomas-a-retrospective-analysis
#19
JOURNAL ARTICLE
Andrew Limavady, Matko Marlais
UNLABELLED: The purpose of this study is to determine the predictive factors of tuberous sclerosis complex (TSC)-associated kidney disease and its progression in children. Retrospective review of children with TSC in a tertiary children's hospital was performed. Relevant data were extracted, and Cox proportional hazards regression was used to establish predictors of kidney lesions. Logistic regression was conducted to identify factors predicting chronic kidney disease (CKD) and high-risk angiomyolipomas (above 3 cm)...
March 14, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38479460/gestational-exposure-to-maternal-systemic-glucocorticoids-and-childhood-risk-of-ckd
#20
JOURNAL ARTICLE
You-Lin Tain, Lung-Chih Li, Hsiao-Ching Kuo, Chien-Ning Hsu
BACKGROUND & OBJECTIVES: The potential effects of antenatal glucocorticoid exposure on the health of children are unclear. We examined the association of gestational exposure to maternal systemic glucocorticoids (SG) and the risk of developing chronic kidney disease (CKD) in childhood. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Newborns cared for at the largest healthcare delivery system in Taiwan between 2004 and 2018...
March 11, 2024: American Journal of Kidney Diseases
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