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CKD and children

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https://www.readbyqxmd.com/read/28098110/hepatitis-c-in-children-with-chronic-kidney-disease-a-single-center-egypt
#1
Doaa Mohammed Youssef, Hanaa Abdo, Ahmed Alakhras, Tamer Adham, Abdelnasser Hussien Mohamoud
Prevalence of hepatitis C varies largely according to geographical distribution, and Egypt so far has the highest prevalence worldwide. The aim of this study was to evaluate hepatitis C infection in chronic kidney disease (CKD) children in our center with regard to its incidence and other morbidities. This is a cross-sectional study involving 50 children with CKD, not on dialysis. All patients underwent a thorough history taking including disease duration and mean duration of admission, clinical examination including blood pressure measurements, and routine laboratory examination such as hemoglobin level, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28093933/acute-kidney-injury-in-idiopathic-nephrotic-syndrome-of-childhood-is-a-major-risk-factor-for-the-development-of-chronic-kidney-disease
#2
Afshan Yaseen, Vina Tresa, Ali Asghar Lanewala, Seema Hashmi, Irshad Ali, Sabeeta Khatri, Muhammed Mubarak
BACKGROUND: Acute kidney injury (AKI) is an important complication of idiopathic nephrotic syndrome (INS) and is associated with adverse outcomes, especially the development of chronic kidney disease (CKD). We aimed to determine the clinical profile of children with INS who developed AKI and its short-term outcome. MATERIAL AND METHODS: This prospective study was conducted from March 2014 to October 2015. A total of 119 children of INS (age: 2-18 years) fulfilling the pediatric RIFLE criteria for the diagnosis of AKI were enrolled and followed up for 3 months to determine the outcome...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28089986/estimating-glomerular-filtration-rate-for-the-full-age-spectrum-from-serum-creatinine-and-cystatin-c
#3
Hans Pottel, Pierre Delanaye, Elke Schaeffner, Laurence Dubourg, Bjørn Odvar Eriksen, Toralf Melsom, Edmund J Lamb, Andrew D Rule, Stephen T Turner, Richard J Glassock, Vandréa De Souza, Luciano Selistre, Karolien Goffin, Steven Pauwels, Christophe Mariat, Martin Flamant, Natalie Ebert
BACKGROUND: We recently published and validated the new serum creatinine (Scr)-based full-age-spectrum equation (FAScrea) for estimating the glomerular filtration rate (GFR) for healthy and kidney-diseased subjects of all ages. The equation was based on the concept of normalized Scr and shows equivalent to superior prediction performance to the currently recommended equations for children, adolescents, adults and older adults. METHODS: Based on an evaluation of the serum cystatin C (ScysC) distribution, we defined normalization constants for ScysC (QcysC = 0...
January 15, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28066881/short-acting-erythropoiesis-stimulating-agents-for-anaemia-in-predialysis-patients
#4
REVIEW
Deirdre Hahn, Christopher I Esezobor, Noha Elserafy, Angela C Webster, Elisabeth M Hodson
BACKGROUND: The benefits of erythropoiesis-stimulating agents (ESA) for chronic kidney disease (CKD) patients have been previously demonstrated. However, the efficacy and safety of short-acting epoetins administered at larger doses and reduced frequency as well as of new epoetins and biosimilars remains uncertain. OBJECTIVES: This review aimed to evaluate the benefits and harms of different routes, frequencies and doses of epoetins (epoetin alpha, epoetin beta and other short-acting epoetins) for anaemia in adults and children with CKD not receiving dialysis...
January 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28033104/micronuclei-and-other-nuclear-anomalies-in-buccal-epithelial-cells-of-children-with-chronic-kidney-disease
#5
Banu Aykanat, Gonca Cakmak Demircigil, Necla Buyan, Esra Baskin, Kaan Gulleroglu, Kibriya Fidan, Umut Selda Bayrakci, Aydin Dalgic, Hamdi Karakayali, Mehmet Haberal, Sema Burgaz
The objective of this study was to reveal the likely genomic instability in children with chronic kidney disease (CKD) using micronucleus (MN) assay on buccal epithelial cells (BEC). We investigated the frequencies of micronuclei and other nuclear anomalies, such as nuclear buds, binucleated cells, condensed chromatin, and karyorrhectic and pyknotic cells in BEC. Children with CKD were grouped as follows: children in the pre-dialysis (PreD) stage (N=17), children on regular haemodialysis (HD) (N=14), and children who have undergone transplantation (Tx) (N=17)...
December 1, 2016: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/28031959/averting-the-legacy-of-kidney-disease-focus-on-childhood
#6
REVIEW
Julie R Ingelfinger, Kamyar Kalantar-Zadeh, Franz Schaefer
World Kidney Day 2016 focuses on kidney disease in childhood and the antecedents of adult kidney disease that can begin in earliest childhood. Chronic kidney disease (CKD) in childhood differs from that in adults, as the largest diagnostic group among children includes congenital anomalies and inherited disorders, with glomerulopathies and kidney disease in the setting of diabetes being relatively uncommon. In addition, many children with acute kidney injury will ultimately develop sequelae that may lead to hypertension and CKD in later childhood or in adult life...
June 2016: Future Science OA
https://www.readbyqxmd.com/read/28013381/pilot-study-of-the-effect-of-cholecalciferol-supplementation-on-hepcidin-in-children-with-chronic-kidney-disease-results-of-the-d-fense-trial
#7
Meredith A Atkinson, Stephen P Juraschek, Michael S Bertenthal, Barbara Detrick, Susan L Furth, Edgar R Miller
BACKGROUND: Hepcidin is a key mediator of the anemia of chronic kidney disease (CKD). There is emerging evidence that 25-hydroxyvitamin D (25D) regulates hepcidin production. METHODS: A randomized controlled trial of daily vitamin D supplementation for 12 weeks was performed with the aim to test the effects of 4000 versus 400 IU of cholecalciferol on serum hepcidin levels in children with non-dialysis CKD recruited at a tertiary care children's hospital. Hepcidin was quantified using a validated competitive enzyme-linked immunosorbent assay...
December 24, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27982687/angiotensinogen-and-interleukin-18-as-markers-of-chronic-kidney-damage-in-children-with-a-history-of-hemolytic-uremic-syndrome
#8
K Lipiec, P Adamczyk, E Świętochowska, K Ziora, M Szczepańska
Hemolytic uremic syndrome (HUS) is a type of thrombotic microangiopathy, in the course of which some patients may develop chronic kidney disease (CKD). It is clinically important to investigate the markers of a poor prognosis. The levels of angiotensinogen (AGT) and interleukin-18 (IL-18) in serum and urine were evaluated. Study was conducted in 29 children with a history of HUS. Serum and urine AGT concentration was significantly higher in children after HUS as compared to the control group. No differences depending on the type of HUS and gender were noted...
December 16, 2016: Physiological Research
https://www.readbyqxmd.com/read/27981896/screening-of-renal-dysfunction-among-burkitt-lymphoma-survivors-by-novel-markers
#9
Laila Metwaly Sherief, Doaa Mohammed Youssef, Hanan Saker Sherbiny, Elhamy Abdelkhalek, Mohamed Talaat, Naglaa Ali Khalifa
BACKGROUND: Burkitt lymphoma (BL) represents the most common pathological type of non-Hodgkin lymphoma in our region. Recently, high success rates have been achieved in BL treatment. Little is known about long-term renal dysfunction in this vulnerable group. In the present study, we tried to detect early chronic kidney diseases (CKD) among BL survivors by using novel screening modalities. PATIENTS AND METHODS: we investigated 53 children (aged 10 ± 2.8 years, 34 boys) who successfully treated for Burkitt lymphoma, based on LMB96 protocol, as "patient group" and 30 children as control...
December 16, 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27882810/what-has-changed-in-the-prevalence-of-hypertension-in-dialyzed-children-during-the-last-decade
#10
Marcin Tkaczyk, Małgorzata Stańczyk, Monika Miklaszewska, Katarzyna Zachwieja, Ryszard Wierciński, Roman Stankiewicz, Agnieszka Firszt-Adamczyk, Jacek Zachwieja, Halina Borzęcka, Ilona Zagożdżon, Beata Leszczyńska, Anna Medyńska, Piotr Adamczyk, Maria Szczepańska, Wojciech Fendler
BACKGROUND: Hypertension very often accompanies progression of chronic kidney disease (CKD) in children. A cross-sectional analysis of hypertension prevalence in dialyzed children in Poland was designed with a comparison with the data previously recorded 10 years earlier. METHODS: Two cohorts of children were analyzed: 59 subjects dialyzed in 2013, and 134 children from the previous study performed in 2003 that were reevaluated according to the current methodology...
November 24, 2016: Renal Failure
https://www.readbyqxmd.com/read/27882009/functional-and-structural-abnormalities-of-the-kidney-and-urinary-tract-in-severely-malnourished-children-a-hospital-based-study
#11
Misbah Anjum, Khemchand N Moorani, Ifra Sameen, Muhammad Ayaz Mustufa, Shazia Kulsoom
OBJECTIVES: The association of malnutrition and systemic diseases like chronic kidney disease (CKD) is well known. Various urinary tract abnormalities may be associated with malnutrition. So objective of current study was to determine the frequency of functional and structural urinary tract abnormalities in severely malnourished children admitted in Nutritional Rehabilitation Unit (NRU) of a tertiary care facility, Karachi. METHODS: This descriptive cases series of 78 children was conducted in NRU from October 2014 - March 2015...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27857786/incidence-of-obsessive-compulsive-disorder-in-children-with-nonmonosymptomatic-primary-nocturnal-enuresis
#12
Parsa Yousefichaijan, Ali Khosrobeigi, Bahman Salehi, Hassan Taherahmadi, Fakhreddin Shariatmadari, Yazdan Ghandi, Saeed Alinejad, Fateme Farhadiruzbahani
INTRODUCTION: Enuresis is defined as the repeated voiding of urine into clothes or bed at least twice a week for at least 3 consecutive months in a child who is at least 5 years of age. The behavior is not due exclusively to the direct physiologic effect of a substance or a general medical condition. Diurnal enuresis defines wetting, whereas awake and nocturnal enuresis refers to voiding during sleep. Primary enuresis occurs in children who have never been consistently dry through the night, whereas secondary enuresis refers the resumption of wetting after at least 6 months of dryness...
July 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27856090/cystatin-c-and-cardiac-measures-in-children-and%C3%A2-adolescents%C3%A2-with-ckd
#13
Tammy M Brady, Kelly Townsend, Michael F Schneider, Christopher Cox, Thomas Kimball, Peace Madueme, Bradley Warady, Susan Furth, Mark Mitsnefes
BACKGROUND: Cardiovascular disease (CVD) is highly prevalent among children with chronic kidney disease (CKD). Cystatin C is an established marker of kidney function and an emerging biomarker for CVD events. We quantified the relationship between cystatin C level and cardiac structure and function over time among children with CKD and assessed whether cystatin C level and diastolic function retained an association after accounting for kidney function. STUDY DESIGN: Prospective cohort study...
November 14, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27846250/reduced-microvascular-density-in-omental-biopsies-of-children-with-chronic-kidney-disease
#14
Dorothea Burkhardt, Maria Bartosova, Betti Schaefer, Niels Grabe, Bernd Lahrmann, Hamoud Nasser, Christian Freise, Axel Schneider, Anja Lingnau, Petra Degenhardt, Bruno Ranchin, Peter Sallay, Rimante Cerkauskiene, Michal Malina, Gema Ariceta, Claus Peter Schmitt, Uwe Querfeld
BACKGROUND: Endothelial dysfunction is an early manifestation of cardiovascular disease (CVD) and consistently observed in patients with chronic kidney disease (CKD). We hypothesized that CKD is associated with systemic damage to the microcirculation, preceding macrovascular pathology. To assess the degree of "uremic microangiopathy", we have measured microvascular density in biopsies of the omentum of children with CKD. PATIENTS AND METHODS: Omental tissue was collected from 32 healthy children (0-18 years) undergoing elective abdominal surgery and from 23 age-matched cases with stage 5 CKD at the time of catheter insertion for initiation of peritoneal dialysis...
2016: PloS One
https://www.readbyqxmd.com/read/27829825/matrix-metalloproteinase-mmp-9-levels-in-children-on-hemodialysis-association-with-mmp-9-c-1562-t-gene-polymorphism-and-vitamin-d-levels
#15
Ashraf Galal, Fatina I Fadel, Enas Mokhtar, Manal F Elshamaa, Eman A Elghoroury, Solaf Kamel, Gamila S M Elsaeed, Eman H Thabet
BACKGROUND AND OBJECTIVES: Data concerning the concentration of matrix metalloproteinase-9 (MMP-9) and its functional polymorphisms in chronic kidney diseases (CKD) are conflicting. The present study aimed to evaluate the levels of MMP-9in children with end stage renal diseases (ESRD) on hemodialysis (HD) and to explore its association with MMP-9 polymorphism and vitamin D levels as an important risk factors for cardiovascular diseases (CVD). METHODS: We studied 55 children with ESRD on hemodialysis and 18 healthy children served as controls...
September 2016: International Journal of Biomedical Science: IJBS
https://www.readbyqxmd.com/read/27827310/cardiovascular-phenotypes-in-children-with-ckd-the-4c-study
#16
Franz Schaefer, Anke Doyon, Karolis Azukaitis, Aysun Bayazit, Nur Canpolat, Ali Duzova, Ana Niemirska, Betul Sözeri, Daniela Thurn, Ali Anarat, Bruno Ranchin, Mieczyslav Litwin, Salim Caliskan, Cengiz Candan, Esra Baskin, Ebru Yilmaz, Sevgi Mir, Marietta Kirchner, Anja Sander, Dieter Haffner, Anette Melk, Elke Wühl, Rukshana Shroff, Uwe Querfeld
BACKGROUND AND OBJECTIVES: Cardiovascular disease is the most important comorbidity affecting long-term survival in children with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The Cardiovascular Comorbidity in Children with CKD Study is a multicenter, prospective, observational study in children ages 6-17 years old with initial GFR of 10-60 ml/min per 1.73 m(2). The cardiovascular status is monitored annually, and subclinical cardiovascular disease is assessed by noninvasive measurements of surrogate markers, including the left ventricular mass index, carotid intima-media thickness, and central pulse wave velocity...
January 6, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27826732/renin-angiotensin-ii-aldosterone-system-blockers-and-time-to-renal-replacement-therapy-in-children-with-ckd
#17
Alison G Abraham, Aisha Betoko, Jeffrey J Fadrowski, Christopher Pierce, Susan L Furth, Bradley A Warady, Alvaro Muñoz
BACKGROUND: Clinical care decisions to treat chronic kidney disease (CKD) in a growing child must often be made without the benefit of evidence from clinical trials. We used observational data from the Chronic Kidney Disease in Children cohort to estimate the effectiveness of renin-angiotensin II-aldosterone system blockade (RAAS) to delay renal replacement therapy (RRT) in children with CKD. METHODS: A total of 851 participants (median age: 11 years, median glomerular filtration rate [GFR]: 52 ml/min/1...
November 8, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27795629/clinicopathological-correlation-and-treatment-response-of-primary-focal-segmental-glomerulosclerosis-in-adults-and-adolescents
#18
J Dhanapriya, T Dineshkumar, N Gopalakrishnan, R Sakthirajan, T Balasubramaniyan
The incidence of focal segmental glomerulosclerosis (FSGS) is approximately 10% in children <6 years, 20% in adolescents, and 20-25% in adults. A retrospective observational study was done to document clinicopathological correlation, treatment response, and risk factors in the progression of chronic kidney disease (CKD) of primary FSGS in adults and adolescents. A total of 170 patients were studied with a mean follow-up of 4.32 ± 1.2 years. FSGS not otherwise specified was the most common subtype (56%) followed by tip variant (24%)...
September 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27789133/racial-differences-in-renal-replacement-therapy-initiation-among-children-with-a-nonglomerular-cause-of-chronic-kidney-disease
#19
Derek K Ng, Marva Moxey-Mims, Bradley A Warady, Susan L Furth, Alvaro Muñoz
PURPOSE: African American (AA) adults with chronic kidney disease (CKD) have a faster progression to end-stage renal disease and are less likely to receive a kidney transplant. It is unclear whether AA children experience renal replacement therapy (RRT) for end-stage renal disease sooner than non-AA children after accounting for socioeconomic status (SES). METHODS: Among children with nonglomerular CKD in the Chronic Kidney Disease in Children study, we investigated time to RRT (i...
November 2016: Annals of Epidemiology
https://www.readbyqxmd.com/read/27767356/etiology-clinical-profile-and-short-term-outcome-of-acute-kidney-injury-in-children-at-a-tertiary-care-pediatric-nephrology-center-in-pakistan
#20
Vina Tresa, Afshan Yaseen, Ali Asghar Lanewala, Seema Hashmi, Sabeeta Khatri, Irshad Ali, Muhammed Mubarak
BACKGROUND: The reported prevalence rates and etiologies of acute kidney injury (AKI) are quite variable in different regions of the world. The current study was planned to determine the etiology, clinical profile, and short-term outcome of pediatric AKI at our hospital. METHODS: A prospective, observational study was carried out from April 2014 to March 2015. All pediatric patients (1 month to ≤15 years) diagnosed as AKI using modified pRIFLE criteria were studied and followed for 3 months to document short-term outcome...
October 21, 2016: Renal Failure
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