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interstitial pneumonia

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https://www.readbyqxmd.com/read/29140119/ct-features-of-the-usual-interstitial-pneumonia-pattern-differentiating-connective-tissue-disease-associated-interstitial-lung-disease-from-idiopathic-pulmonary-fibrosis
#1
Jonathan H Chung, Christian W Cox, Steven M Montner, Ayodeji Adegunsoye, Justin M Oldham, Aliya N Husain, Rekha Vij, Imre Noth, David A Lynch, Mary E Strek
OBJECTIVE: A substantial proportion of cases of usual interstitial pneumonia (UIP) are due to connective tissue disease (CTD)-associated interstitial lung disease (ILD). The purpose of this study was to determine whether specific CT findings can help differentiate a UIP pattern of CTD-ILD from a UIP pattern of idiopathic pulmonary fibrosis (IPF) and whether these signs are associated with survival. MATERIALS AND METHODS: Adults visiting an ILD clinic from 2006 to 2015 enrolled in a research registry with a multidisciplinary diagnosis of CTD-ILD or IPF and a UIP pattern at high-resolution CT were included in the study...
November 15, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29138550/overlaps-and-uncertainties-of-smoking-related-idiopathic-interstitial-pneumonias
#2
REVIEW
So Hyeon Bak, Ho Yun Lee
Smoking-related interstitial lung disease (ILD) consists of a heterogeneous group of disorders that are considered a distinct entity. The 2013 American Thoracic Society and European Respiratory Society recommendations classified respiratory bronchiolitis (RB)/RB-ILD and desquamative interstitial pneumonia (DIP) as smoking-related idiopathic interstitial pneumonias (IIPs). The overlapping histopathological and radiological patterns of smoking-related IIPs must be considered. Overlap patterns of smoking-related IIPs are not easily classified as a single disorder...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29128757/lethal-murine-infection-model-for-human-respiratory-disease-associated-pteropine-orthoreovirus
#3
Yuta Kanai, Takahiro Kawagishi, Minoru Okamoto, Yusuke Sakai, Yoshiharu Matsuura, Takeshi Kobayashi
Pteropine orthoreovirus (PRV) is an emerging bat-borne human pathogen causing severe respiratory illness. To date, however, the evaluation of PRV virulence has largely depended on the limited numbers of clinical cases owing to the lack of animal models. To develop an in vivo model of PRV infection, an inbred C3H mouse strain was infected intranasally with pathogenic PRV strain Miyazaki-Bali/2007. C3H mice suffered severe lung infection with significant body weight reduction and died within 7 days after intranasal infection...
November 9, 2017: Virology
https://www.readbyqxmd.com/read/29128013/bronchiolitis-obliterans-syndrome-and-other-late-pulmonary-complications-after-allogeneic-hematopoietic-stem-cell-transplantation
#4
REVIEW
Anne Bergeron, Guang-Shing Cheng
As more individuals survive their hematologic malignancies after allogeneic hematopoietic stem cell transplantation (HSCT), there is growing appreciation of the late organ complications of this curative procedure for malignant and nonmalignant hematologic disorders. Late noninfectious pulmonary complications encompass all aspects of the bronchopulmonary anatomy. There have been recent advances in the diagnostic recognition and management of bronchiolitis obliterans syndrome, which is recognized as a pulmonary manifestation of chronic graft-versus-host disease...
December 2017: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/29124429/what-factors-determine-the-survival-of-patients-with-an-acute-exacerbation-of-interstitial-lung-disease-after-lung-cancer-resection
#5
Masahiro Miyajima, Atsushi Watanabe, Toshihiko Sato, Satoshi Teramukai, Masahito Ebina, Kazuma Kishi, Yukihiko Sugiyama, Haruhiko Kondo, Satoru Kobayashi, Yutaka Takahashi, Hiroyuki Ito, Ryoji Yamamoto, Shigeki Sawada, Hideki Fujimori, Kazunori Okabe, Jun Arikura, Yasushi Shintani, Hiroshige Nakamura, Shinichi Toyooka, Tohru Hasumi, Takehiro Watanabe, Yoshinobu Hata, Hisashi Iwata, Minoru Aoki, Kazuhito Funai, Shuhei Inoue, Osamu Kawashima, Tomohiko Iida, Hiroshi Date
PURPOSES: Acute exacerbation of interstitial pneumonia (AEIP) is a leading cause of death after lung cancer resection in patients with interstitial lung disease. METHODS: We retrospectively analyzed 1763 patients with non-small cell lung cancer with a clinical diagnosis of interstitial lung disease (ILD) who underwent lung cancer resection between 2000 and 2009 at 61 hospitals in Japan. AEIP occurred in 164 of 1763 (9.3%) patients with a mortality rate of 43.9% (72/164)...
November 9, 2017: Surgery Today
https://www.readbyqxmd.com/read/29124008/rare-complicated-parapneumonic-effusion-mycoplasma-pneumoniae-with-new-onset-lupus-flare-case-report-and-literature-review
#6
Bharat Bajantri, Shaik Danial, Richard Duncalf, Misbahuddin Khaja
Mycoplasma pneumoniae has been associated with respiratory tract infections. Mycoplasma pneumoniae pneumonia-related pleural effusion is rarely reported. Extra-pulmonary abnormalities such as encephalitis, myocarditis, glomerulonephritis, and myringitis have been reported. However pulmonary manifestations in systemic lupus erythematosus include pneumonitis, pleurisy, interstitial lung disease, and thromboembolic disease. We present the case of a 26-year-old male who came for evaluation of fever, cough, and shortness of breath with right-sided chest pain...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29123520/dexd-h-box-helicase-36-signaling-via-myeloid-differentiation-primary-response-gene-88-contributes-to-nf-%C3%AE%C2%BAb-activation-to-type-2-porcine-reproductive-and-respiratory-syndrome-virus-infection
#7
Huiyuan Jing, Yanrong Zhou, Liurong Fang, Zhen Ding, Dang Wang, Wenting Ke, Huanchun Chen, Shaobo Xiao
DExD/H-box helicase 36 (DHX36) is known to be an ATP-dependent RNA helicase that unwinds the guanine-quadruplexes DNA or RNA, but emerging data suggest that it also functions as pattern recognition receptor in innate immunity. Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has been devastating the swine industry worldwide. Interstitial pneumonia is considered to be one of the most obvious clinical signs of PRRSV infection, suggesting that the inflammatory response plays an important role in PRRSV pathogenesis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29118859/pleuropulmonary-manifestation-in-patients-with-rheumatoid-arthritis-in-saudi-arabia
#8
Omer S B Alamoudi, Suzan Mansour Attar
BACKGROUND AND OBJECTIVES: Pleuropulmonary (PP) involvement in rheumatoid arthritis (RA) is associated with high morbidity and mortality. Nevertheless, limited data are available regarding lung complications in the Middle East, especially in Saudi Arabia. The objectives of the current study were to determine the prevalence of PP manifestations and to identify the associated risk factors. METHODS: This was a retrospective study involving 419 patients diagnosed at a tertiary center over a 12...
October 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29113323/reduced-expression-of-bmp3-contributes-to-the-development-of-pulmonary-fibrosis-and-predicts-the-unfavorable-prognosis-in-iip-patients
#9
Xiaoting Yu, Pan Gu, Ziling Huang, Xia Fang, Ying Jiang, Qun Luo, Xia Li, Xuyou Zhu, Mengna Zhan, Junbang Wang, Lichao Fan, Rongchang Chen, Juehua Yu, Yingying Gu, Aibin Liang, Xianghua Yi
Idiopathic pulmonary fibrosis (IPF) and idiopathic nonspecific interstitial pneumonia (INSIP) are two related diseases involving varying degrees of pulmonary fibrosis with no effective cure. Bone morphogenetic protein 3 (BMP3) is a member of the transforming growth factor-β (TGF-β) super-family, which has not been implicated in pulmonary fibrosis previously. In this study, we aimed to investigate the potential role of BMP3 playing in pulmonary fibrosis from clinical diagnosis to molecular signaling regulation...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29110735/development-of-interstitial-pneumonia-during-treatment-with-eribulin-a-case-report
#10
Kota Nakamura, Motoyasu Kato, Yosuke Miyashita, Osamu Nagashima, Shinichi Sasaki, Shigeru Tominaga, Kazuhisa Takahashi
BACKGROUND: Eribulin is typically used to treat patients with advanced breast cancer, and anti-cancer agents often cause the development of interstitial pneumonia in Japanese patients with advanced cancer. However, few case reports have addressed eribulin-induced interstitial pneumonia. Herein, we report a rare case of interstitial pneumonia-specifically, organized pneumonia-during treatment with eribulin in a patient with advanced breast cancer. CASE PRESENTATION: A 52-year-old Japanese woman was diagnosed as having advanced breast cancer 3 years before the admission described in the present report...
November 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29109947/acute-exacerbation-in-interstitial-lung-disease
#11
REVIEW
Gabriela Leuschner, Jürgen Behr
Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) has been defined as an acute, clinically significant deterioration that develops within less than 1 month without obvious clinical cause like fluid overload, left heart failure, or pulmonary embolism. Pathophysiologically, damage of the alveoli is the predominant feature of AE-IPF which manifests histopathologically as diffuse alveolar damage and radiologically as diffuse, bilateral ground-glass opacification on high-resolution computed tomography...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29108196/-a-case-of-interstitial-pneumonia-induced-by-interferon-therapy-for-chronic-hepatitis-c
#12
X H Gao, X F Hao, X Ji, J J Xin, G H Xu
No abstract text is available yet for this article.
September 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29103686/pathogenicity-of-a-newly-emerged-recombined-porcine-reproductive-and-respiratory-syndrome-virus-strain-subgenotype-iii-in-china
#13
Jianguo Dong, Yanwu Wang, Linyang Yu, Pengfei Zhang, Xiangcong Liu, Leyi Zhang, Yanling Liu, Pengshuai Liang, Lei Wang, Changxu Song
Porcine reproductive and respiratory syndrome virus (PRRSV) is a severe pathogen that causes enormous economic losses to the swine industry worldwide. Since its first report in the 1980s, PRRSV has undergone extensive variation. In the previous study, we demonstrated that the GDsg strain was a new recombined virus between the low pathogenic field strain QYYZ and the vaccine strain JXA1-P80, belonging to the newly emerging type 2 PRRSV subgenotype III. In this study, the pathogenicity of a new recombined strain GDsg for pigs was analyzed...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29103257/-fever-hepatic-dysfunction-and-interstitial-pneumonia-caused-by-intravesical-bacillus-calmette-guerin-bcg-instillation-after-urethral-bougie-a-case-report
#14
Satoshi Nitta, Shotaro Sakka, Tsuyoshi Endo, Manabu Komine, Masakazu Tsutsumi, Hiroyuki Nishiyama
A 60-year-old man had a past history of urothelial carcinoma of the left renal pelvis treated with laparoscopic left total nephroureterectomy in October 2004. He underwent transurethral resection of the bladder tumor (TUR-Bt) twice for recurrence of urothelial carcinoma in the bladder in April 2014 and February 2015, and subsequently received intravesical Bacillus Calmette-Guerin (BCG) instillation at weekly intervalsfor prevention of recurrence. In November 2016, a year and a half after BCG induction, he received BCG therapy after urethral bougie to dilate the urethral stricture...
October 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29097816/anti-inflammatory-and-anti-fibrotic-effects-of-intravenous-adipose-derived-stem-cell-transplantation-in-a-mouse-model-of-bleomycin-induced-interstitial-pneumonia
#15
Takuya Kotani, Ryota Masutani, Takayasu Suzuka, Katsuhiro Oda, Shigeki Makino, Masaaki Ii
Adipose-derived stem cells (AdSCs) have recently been considered a useful treatment tool for autoimmune disease because of their anti-inflammatory and immunosuppressive effects. We investigated the therapeutic effect of intravenous AdSC transplantation in a mouse model of bleomycin-induced lung injury. AdSCs accumulated in the pulmonary interstitium and inhibited both inflammation and fibrosis in the lung, markedly improving the survival rate of mice with bleomycin-induced lung injury in a cell number-dependent manner...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29093389/the-onset-of-eosinophilic-pneumonia-preceding-anti-synthetase-syndrome
#16
Yoshimasa Hachisu, Yasuhiko Koga, Noriaki Sunaga, Chiharu Kashiwagi, Yuri Sawada, Yasuyuki Saito, Yusuke Tsukagoshi, Norimitsu Kasahara, Reiko Sakurai, Hiroaki Tsurumaki, Masakiyo Yatomi, Kyoichi Kaira, Akihiro Ono, Toshitaka Maeno, Takeshi Hisada
A 66-year-old man had been treated with prednisolone for eosinophilic pneumonia for 8 years. His slowly progressing cough and dyspnea were accompanied by elevated levels of fibrotic serological markers and an increased reticular shadow on chest computed tomography images. The patient had recently tested positive for anti-EJ antibodies, a type of anti-aminoacyl-tRNA synthetase antibody; therefore, we diagnosed him with an exacerbation of interstitial pneumonia due to anti-synthetase syndrome (ASS). He was treated with tacrolimus and an increased prednisolone dosage...
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29091912/diabetes-mellitus-increases-the-susceptibility-to-encephalitozoonosis-in-mice
#17
Aldo Francisco Neto, Paulo Ricardo Dell'Armelina Rocha, Elizabeth Christina Perez, José Guilherme Xavier, Giovani Bravin Peres, Diva Denelle Spadacci-Morena, Anuska Marcelino Alvares-Saraiva, Maria Anete Lallo
Microsporidiosis are diseases caused by opportunistic intracellular fungi in immunosuppressed individuals, as well as in transplanted patients, the elderly and children, among others. Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia and decreased T cell response, neutrophil function, humoral immunity failure, increasing the susceptibility to infections. Here, we investigated the susceptibility of streptozotocin (STZ)-induced type I diabetic and/or immunosuppressed mice to encephalitozoonosis by Encephalitozoon cuniculi...
2017: PloS One
https://www.readbyqxmd.com/read/29090993/the-genomic-detection-of-usual-interstitial-pneumonia-from-transbronchial-biopsy-tissue-a-dress-rehearsal-for-the-future
#18
Athol U Wells, Katerina M Antoniou
No abstract text is available yet for this article.
November 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29081475/sudden-death-of-an-indian-peafowl-pavo-cristatus-at-a-zoo-due-to-non-pigmented-serratia-marcescens-infection
#19
Seung-Hun Lee, Sang-Joon Park, Dongmi Kwak, Kyoo-Tae Kim
A 16-year-old female Indian peafowl (Pavo cristatus) died two days after recognition of conjunctivitis in the right eye, anorexia and depression. Gross necropsy revealed a thick pseudomembrane under the eyelid and hydropericardium. Histopathological examination revealed hepatocellular necrosis, sinusoidal and vascular congestion and infiltrated inflammatory cells. Infiltration by inflammatory cells was noted in the epicardium. The lungs had mild interstitial pneumonia with the extensive congestion within the capillaries of the air sacs...
October 30, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29079188/klf2-attenuates-bleomycin-induced-pulmonary-fibrosis-and-inflammation-with-regulation-of-ap-1
#20
Jian Shi, Li-Rong Zhou, Xiao-Sheng Wang, Jun-Feng Du, Ming-Ming Jiang, Zhan Song, Guang-Chao Han, Zhi-Tao Mai
Pulmonary fibrosis (PF) is a chronic, fibrosing interstitial pneumonia and devastating disease. Here we investigated the potential roles of Kruppel-like factor 2 (KLF2) on pulmonary fibrosis and inflammation response. A mouse model of pulmonary fibrosis was established by intratracheal injection of bleomycin (BLM). The mRNA and protein levels of KLF2 were assayed by RT-PCR and Western blotting respectively. The extent of lung fibrosis was determined using hematoxylin and eosin (HE) staining and Masson's trichrome staining, and the hydroxyproline content was quantified...
October 24, 2017: Biochemical and Biophysical Research Communications
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