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Dpp4 hypoxia

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https://www.readbyqxmd.com/read/27230812/genome-wide-analysis-reveals-adaptation-to-high-altitudes-in-tibetan-sheep
#1
Caihong Wei, Huihua Wang, Gang Liu, Fuping Zhao, James W Kijas, Youji Ma, Jian Lu, Li Zhang, Jiaxue Cao, Mingming Wu, Guangkai Wang, Ruizao Liu, Zhen Liu, Shuzhen Zhang, Chousheng Liu, Lixin Du
Tibetan sheep have lived on the Tibetan Plateau for thousands of years; however, the process and consequences of adaptation to this extreme environment have not been elucidated for important livestock such as sheep. Here, seven sheep breeds, representing both highland and lowland breeds from different areas of China, were genotyped for a genome-wide collection of single-nucleotide polymorphisms (SNPs). The FST and XP-EHH approaches were used to identify regions harbouring local positive selection between these highland and lowland breeds, and 236 genes were identified...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26881257/hypoxia-alters-the-expression-of-dipeptidyl-peptidase-4-and-induces-developmental-remodeling-of-human-preadipocytes
#2
Helena H Chowdhury, Jelena Velebit, Nataša Radić, Vito Frančič, Marko Kreft, Robert Zorec
Dipeptidyl peptidase 4 (DPP4), a transmembrane protein, has been identified in human adipose tissue and is considered to be associated with obesity-related type 2 diabetes. Since adipose tissue is relatively hypoxic in obese participants, we investigated the expression of DPP4 in human preadipocytes (hPA) and adipocytes in hypoxia, during differentiation and upon insulin stimulation. The results show that DPP4 is abundantly expressed in hPA but very sparsely in adipocytes. During differentiation in vitro, the expression of DPP4 in hPA is reduced on the addition of differentiation medium, indicating that this protein can be hPA marker...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/25217834/shedding-of-dipeptidyl-peptidase-4-is-mediated-by-metalloproteases-and-up-regulated-by-hypoxia-in-human-adipocytes-and-smooth-muscle-cells
#3
Diana Röhrborn, Jürgen Eckel, Henrike Sell
Dipeptidyl peptidase 4 is an important drug target for diabetes and a novel adipokine. However, it is unknown how soluble DPP4 (sDPP4) is cleaved from the cell membrane and released into the circulation. We show here that MMP1, MMP2 and MMP14 are involved in DPP4 shedding from human vascular smooth muscle cells (SMC) and MMP9 from adipocytes. Hypoxia increased DPP4 shedding from SMC which is associated with increased mRNA expression of MMP1. Our data suggest that constitutive as well as hypoxia-induced DPP4 shedding occurs due to a complex interplay between different MMPs in cell type-specific manner...
November 3, 2014: FEBS Letters
https://www.readbyqxmd.com/read/23700522/differentiation-of-human-adipocytes-at-physiological-oxygen-levels-results-in-increased-adiponectin-secretion-and-isoproterenol-stimulated-lipolysis
#4
Susanne Famulla, Raphaela Schlich, Henrike Sell, Jürgen Eckel
Adipose tissue (AT) hypoxia occurs in obese humans and mice. Acute hypoxia in adipocytes causes dysregulation of adipokine secretion with an increase in inflammatory factors and diminished adiponectin release. O2 levels in humans range between 3 and 11% revealing that conventional in vitro culturing at ambient air and acute hypoxia treatment (1% O2) are performed under non-physiological conditions. In this study, we mimicked physiological conditions by differentiating human primary adipocytes under 10% or 5% O2 in comparison to 21% O2...
July 1, 2012: Adipocyte
https://www.readbyqxmd.com/read/18339868/hypoxia-inducible-factor-1-target-genes-as-indicators-of-tumor-vessel-response-to-vascular-endothelial-growth-factor-inhibition
#5
Duyen T Dang, Sang Y Chun, Kyunghee Burkitt, Masako Abe, Shaowei Chen, Pamela Havre, Nicola J Mabjeesh, Elisabeth I Heath, Nicholas J Vogelzang, Marcia Cruz-Correa, Douglas W Blayney, William D Ensminger, Brad St Croix, Nam H Dang, Long H Dang
Antiangiogenic therapy improves survival in patients with advanced stage cancers. Currently, there are no reliable predictors or markers for tumor vessel response to antiangiogenic therapy. To model effective antiangiogenic therapy, we disrupted the VEGF gene in three representative cancer cell lines. HCT116 xenografts had low proportions of endothelial tubes covered by pericytes that stained with alpha-smooth muscle actin (SMA) antibody. Upon disruption of VEGF, HCT116(VEGF-/-) xenografts had significantly decreased tumor microvessel perfusion compared with their parental counterparts...
March 15, 2008: Cancer Research
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