Eriko Komiya, Mitsutoshi Tominaga, Ryo Hatano, Yuji Kamikubo, Sumika Toyama, Hakushun Sakairi, Kotaro Honda, Takumi Itoh, Yayoi Kamata, Munehiro Tsurumachi, Ryoma Kishi, Kei Ohnuma, Takashi Sakurai, Chikao Morimoto, Kenji Takamori
BACKGROUND: Mechanical alloknesis (or innocuous mechanical stimuli-evoked itch) often occurs in dry skin-based disorders such as atopic dermatitis and psoriasis. However, the molecular and cellular mechanisms underlying mechanical alloknesis remain unclear. We recently reported the involvement of CD26 in the regulation of psoriatic itch. This molecule exhibits dipeptidyl peptidase IV (DPPIV) enzyme activity and exerts its biologic effects by processing various substances, including neuropeptides...
August 17, 2021: Journal of Allergy and Clinical Immunology