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https://www.readbyqxmd.com/read/28221188/treatment-of-cervical-intraepithelial-neoplasia-patients-preferences-for-surgery-or-immunotherapy-with-imiquimod
#1
Margot M Koeneman, Brigitte A Essers, Cornelis G Gerestein, Anna J M van de Sande, Rogier J N T M Litjens, Dieuwke Boskamp, Medi F J Goossens, Heleen J Beekhuizen, Roy F P M Kruitwagen, Arnold J Kruse, Carmen D Dirksen
OBJECTIVE: Imiquimod has been studied as a noninvasive pharmacological treatment alternative to large loop excision of the transformation zone (LLETZ) for high-grade cervical intraepithelial neoplasia (CIN), to prevent long-term obstetric complications from surgical treatment. This study aims to investigate womens' preferences for treatment of high-grade CIN with imiquimod or LLETZ. METHODS: A labeled discrete choice experiment was conducted among 100 women with abnormal cervical cytology in 5 hospitals in the Netherlands between March 2014 and December 2015...
February 17, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28219333/uk-national-clinical-audit-management-of-pregnancies-in-women-with-hiv
#2
S Raffe, H Curtis, P Tookey, H Peters, A Freedman, Y Gilleece
BACKGROUND: The potential for HIV transmission between a pregnant woman and her unborn child was first recognized in 1982. Since then a complex package of measures to reduce risk has been developed. This project aims to review UK management of HIV in pregnancy as part of the British HIV Association (BHIVA) audit programme. METHODS: The National Study of HIV in Pregnancy and Childhood (NSHPC), a population-based surveillance study, provided data for pregnancies with an expected delivery date from 1/1/13 - 30/6/14...
February 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28219028/identifying-women-at-risk-for-sustained-postpartum-anxiety
#3
Cindy-Lee Dennis, Hilary K Brown, Kobra Falah-Hassani, Flavia Casasanta Marini, Simone N Vigod
INTRODUCTION: To describe the prevalence of sustained postpartum anxiety and to develop a multifactorial predictive model to assist in targeted screening procedures. METHODS: In a population-based cohort in a health region near Vancouver, Canada, 522 mothers completed a mailed questionnaire at 1, 4, and 8 weeks postpartum measuring socio-demographic, biological, pregnancy-related, life stressor, social support, obstetric, and maternal adjustment factors. We undertook a sequential logistic regression analysis to develop a multifactorial predictive model of sustained postpartum anxiety, as measured by a State Trait Anxiety Inventory (STAI) score >40 at 1 week and/or 4 weeks, and 8 weeks postpartum...
February 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28218771/travel-during-pregnancy-considerations-for-the-obstetric-provider
#4
Kathleen M Antony, Deborah Ehrenthal, Ann Evensen, J Igor Iruretagoyena
Importance: Travel among US citizens is becoming increasingly common, and travel during pregnancy is also speculated to be increasingly common. During pregnancy, the obstetric provider may be the first or only clinician approached with questions regarding travel. Objective: In this review, we discuss the reasons women travel during pregnancy, medical considerations for long-haul air travel, destination-specific medical complications, and precautions for pregnant women to take both before travel and while abroad...
February 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28218564/-a-brief-of-gestational-diabetes-mellitus-risk-factors-and-current-criteria-of-diagnosis
#5
Zahra Al-Aissa, Orsolya Hadarits, Klára Rosta, András Zóka, János Rigó, Gábor Firneisz, Anikó Somogyi
Diabetes is one of the most common metabolic disorders that may cause pathological pregnancy. Treating diabetes recognized during pregnancy results in lowering maternal and fetal complications. These patients present higher risk for excessive weight gain, preeclampsia, delivery with cesarean sections, high risk of developing type 2 diabetes and cardiovascular disease in the future. Fetuses of mothers with gestational diabetes are at higher risk for macrosomia and birth trauma, after delivery they present higher risk of developing neonatal hypoglycemia, hyperbilirubinemia, and respiratory distress syndrome...
February 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28217601/prevalence-of-rubella-specific-igg-antibodies-in-unimmunized-young-female-population
#6
Jayakrishnan Thayyil, Vidya Kuniyil, Anitha P Moorkoth, Bhaskar Rao, Paramasivam Selvam
CONTEXT: Rubella is a mild self-limiting disease all over the world; nevertheless, it is of significant public health importance due to its teratogenic effect of congenital rubella syndrome. Rubella vaccine is currently not included in the national immunization program in India. Rubella-specific IgG in the unvaccinated population is a marker of previous rubella infection. Rubella IgG estimation in children will provide data for initiation and necessary modification to the immunization strategy...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28216915/a-rare-and-interesting-case-of-heterotopic-cervical-pregnancy-after-intracytoplasmic-sperm-injection-and-embryo-transfer
#7
Ritu Punhani, Kundavi Shankar, Thankam R Varma
The wide use of assisted reproductive technologies has contributed to the increased risk of ectopic and subsequently heterotopic pregnancy (HP) rate. Cervical ectopic pregnancy is a very rare and life-threatening form of ectopic pregnancy that can also present as HP. We are describing here a case of 34-year-old woman who presented with bleeding heterotopic cervical pregnancy (HCP). The concomitant viable cervical and intrauterine pregnancies were diagnosed at 8 weeks of gestation. Selective fetal reduction was done for cervical pregnancy following which uterine artery embolization was done as a life-saving measure, and subsequently, injection methotrexate was also given...
October 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28216561/maternal-vitamin-d-status-in-the-late-second-trimester-and-the-risk-of-severe-preeclampsia-in-southeastern-china
#8
Xin Zhao, Rui Fang, Renqiang Yu, Daozhen Chen, Jun Zhao, Jianping Xiao
The association between maternal vitamin D deficiency and the risk of severe preeclampsia is still debated. In the present study, we aimed to evaluate vitamin D status in Chinese pregnant women and investigate its correlation with the odds of developing severe preeclampsia. A cohort study was performed on 13,806 pregnant women who routinely visited the antenatal care clinics and subsequently delivered at the Wuxi Maternity and Child Health Hospital. All the subjects in the cohort had their serum 25-hydroxyvitamin D (25(OH)D) concentrations measured during pregnancy...
February 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28216421/the-impacts-of-cord-blood-cotinine-and-glutathione-s-transferase-gene-polymorphisms-on-birth-outcome
#9
Kuan-Han Huang, An-Kuo Chou, Suh-Fang Jeng, Sharon Ng, Chia-Jung Hsieh, Mei-Huei Chen, Pau-Chung Chen, Wu-Shiun Hsieh
BACKGROUND: This study aimed to investigate the association between cord blood cotinine levels and birth outcome, and to determine whether fetal metabolic gene polymorphisms of glutathione-S-transferase (GST) modulate the effect of environmental tobacco smoke exposure during pregnancy. METHODS: This study included 328 maternal and neonatal pairs. Maternal and cord blood cotinine levels were measured using high performance liquid chromatography. The GST T1 (GSTT1) and GST M1 (GSTM1) polymorphisms were examined using the polymerase chain reaction method...
January 17, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28216380/a-population-based-analysis-of-predictors-of-influenza-vaccination-uptake-in-pregnant-women-the-effect-of-gestational-and-calendar-time
#10
Luz Maria Vilca, Aman Verma, David Buckeridge, Magda Campins
Pregnant women are vaccinated against influenza less frequently than other high-risk groups. To design effective vaccination strategies, we must understand how decisions regarding vaccination may vary by trimester and over vaccination campaigns. We used a Cox model indexed by calendar time to estimate the effect of gestational trimester and other factors on vaccination uptake in a large cohort of pregnant women in Catalonia (Spain) during 2008-09 to 2012-13 influenza vaccination campaigns. We analyzed 247,316 pregnancies...
February 16, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28215397/clinical-mimics-an-emergency-medicine-focused-review-of%C3%A2-influenza-mimics
#11
Erica Simon, Brit Long, Alex Koyfman
BACKGROUND: Influenza viruses are a significant cause of morbidity and mortality in the United States. Given the wide range of symptoms, emergency physicians must maintain a broad differential diagnosis in the evaluation and treatment of patients presenting with influenza-like illnesses. OBJECTIVE: This review addresses objective and subjective symptoms commonly associated with influenza and discusses important mimics of influenza viruses, while offering a practical approach to their clinical evaluation and treatment...
February 15, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28212958/economic-evaluations-comparing-a-trial-of-labor-with-an-elective-repeat-cesarean-delivery-a-systematic-review
#12
REVIEW
Anna Joy Rogers, Nathaniel G Rogers, Meredith L Kilgore, Akila Subramaniam, Lorie M Harper
BACKGROUND: For women who have had a previous low transverse cesarean delivery, the decision to undergo a trial of labor after cesarean (TOLAC) or an elective repeat cesarean delivery (ERCD) has important clinical and economic ramifications. OBJECTIVES: To evaluate the cost-effectiveness of the alternative choices of a TOLAC and an ERCD for women with low-risk, singleton gestation pregnancies. METHODS: We searched EMBASE, MEDLINE, CINAHL, Cochrane Library, EconLit, and the Cost-Effectiveness Analysis Registry with no language, publication, or date restrictions up until October 2015...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212612/african-ancestry-is-associated-with-facial-melasma-in-women-a-cross-sectional-study
#13
Maria Paula Barbieri D'Elia, Marcela Calixto Brandão, Bruna Ribeiro de Andrade Ramos, Márcia Guimarães da Silva, Luciane Donida Bartoli Miot, Sidney Emanuel Batista Dos Santos, Hélio Amante Miot
BACKGROUND: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Here, we evaluated the association between genetic ancestry and facial melasma. METHODS: A cross-sectional study involving women with melasma and an age-matched control group from outpatients at FMB-Unesp, Botucatu-SP, Brazil was performed...
February 17, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28211106/a-pilot-randomised-controlled-trial-investigating-a-mediterranean-diet-intervention-in-pregnant-women-for-the-primary-prevention-of-allergic-diseases-in-infants
#14
D A Sewell, V S Hammersley, A Robertson, G Devereux, A Stoddart, C J Weir, A Worth, A Sheikh
BACKGROUND: Observational studies suggest a potentially protective role of the Mediterranean diet (MD) in allergic diseases, including asthma. Large scale randomised controlled trials (RCTs) are needed to test the hypothesised allergy-prevention benefits of a MD during pregnancy. The present two-arm pilot RCT in pregnant women at high-risk of having a child who would develop allergic disease investigated maternal recruitment, retention and acceptability of an MD dietary intervention in the UK...
February 16, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28210482/delayed-interval-delivery-can-save-the-second-twin-evidence-from-a-systematic-review
#15
REVIEW
S Feys, Y Jacquemyn
BACKGROUND: In case of preterm birth in twins, it is not well established if the second twin benefits from a delayed-interval delivery. OBJECTIVE: The main objective of this systematic review is to evaluate survival benefit of the second twin from delayed interval delivery compared to the first twin. Secondly, we will evaluate the survival benefit of the procedure when performed equal to or after 24 weeks gestational age of the first born. METHODS: Delayed interval delivery was defined as every attempt to perform a delayed interval delivery with at minimum placement of a high ligature of the umbilical cord and a delay of delivery of at least 24 hours...
December 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28209774/methyl-donor-supplementation-alters-cognitive-performance-and-motivation-in-female-offspring-from-high-fat-diet-fed-dams
#16
Sarah E McKee, Nicola M Grissom, Christopher T Herdt, Teresa M Reyes
During gestation, fetal nutrition is entirely dependent on maternal diet. Maternal consumption of excess fat during pregnancy has been linked to an increased risk of neurologic disorders in offspring, including attention deficit/hyperactivity disorder, autism, and schizophrenia. In a mouse model, high-fat diet (HFD)-fed offspring have cognitive and executive function deficits as well as whole-genome DNA and promoter-specific hypomethylation in multiple brain regions. Dietary methyl donor supplementation during pregnancy or adulthood has been used to alter DNA methylation and behavior...
February 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28209547/pregnancy-after-urinary-diversion-at-young-ages-risks-and-outcome
#17
N Huck, S Schweizerhof, P Honeck, A Neisius, J Thüroff, R Stein
OBJECTIVE: To assess the urological and obstetric outcomes during and after pregnancy following urinary diversion (UD) performed during childhood or adolescence. PATIENTS AND METHODS: From our urinary diversion database, we identified 25 females who became pregnant between 1981 and 2013. Reasons for urinary diversion were neurogenic bladder, exstrophy, trauma, sinus urogenitalis and interstitial cystitis. 17 had continent cutaneous diversion, 4 continent anal diversion and 4 colonic conduit...
February 13, 2017: Urology
https://www.readbyqxmd.com/read/28209492/reproductive-considerations-in-the-setting-of-chronic-viral-illness
#18
REVIEW
Brent M Hanson, Jessie A Dorais
Special considerations must be taken when patients with human immunodeficiency virus (HIV), Hepatitis B, or Hepatitis C desire to achieve pregnancy. Patients with chronic viral illnesses desire children at rates similar to the general population, and options are available to decrease both vertical transmission and viral transmission between partners. Preconception counseling or consultation with fertility specialists is imperative in patients with HIV, Hepatitis B, and Hepatitis C so that reproductive goals can be addressed and optimized...
February 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28209484/successful-provision-of-inter-hospital-extracorporeal-cardiopulmonary-resuscitation-for-acute-post-partum-pulmonary-embolism
#19
C McDonald, J Laurie, S Janssens, C Zazulak, P Kotze, K Shekar
Mortality during pregnancy in a well-resourced setting is rare, but acute pulmonary embolism is one of the leading causes. We present the successful use of extracorporeal cardiopulmonary resuscitation (eCPR) in a 22-year old woman who experienced cardiopulmonary collapse following urgent caesarean section in the setting of a sub-massive pulmonary embolus. Resources and personnel to perform eCPR were not available at the maternity hospital and were recruited from an adjacent pediatric hospital. Initial care used low blood flow extracorporeal membrane oxygenation (ECMO) with pediatric ECMO circuitry, which was optimized when the team from a nearby adult cardiac hospital arrived...
January 9, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28209334/pregnancy-in-chronic-kidney-disease-and-kidney-transplantation
#20
REVIEW
Philip Webster, Liz Lightstone, Dianne B McKay, Michelle A Josephson
Chronic kidney disease (CKD) affects up to 6% of women of childbearing age in high income countries, and is estimated to affect 3% of pregnant women. Advanced renal dysfunction, proteinuria, hypertension, and poorly controlled underlying primary renal disease are all significant risks for adverse maternal, fetal, and renal outcomes. In order to achieve the best outcomes, it is therefore of paramount importance that these pregnancies are planned, where possible, to allow the opportunity to counsel women and their partners in advance and to optimize these risks...
February 13, 2017: Kidney International
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