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https://www.readbyqxmd.com/read/28320049/d-%C3%AE-hydroxybutyrate-promotes-functional-recovery-and-relieves-pain-hypersensitivity-in-mice-with-spinal-cord-injury
#1
Jiao Qian, Wenjun Zhu, Ming Lu, Bin Ni, Jun Yang
BACKGROUND AND PURPOSE: Spinal cord injury (SCI) leads to severe motor and sensory dysfunction and significantly reduces the quality of life. The aim of present work was to investigate the effect of administration of exogenous D-β-hydroxybutyrate (DBHB) on functional recovery and neuropathic pain in spinal-cord-injured mice. EXPERIMENTAL APPROACH: Mice were given a moderate-severe thoracic spinal contusion injury at the T9-10 level, and treated with exogenous DBHB...
March 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28318981/idiopathic-intradural-dorsal-thoracic-arachnoid-cysts-a-case-series-and-review-of-the-literature
#2
Heath French, Arjuna Somasundaram, Michael Biggs, Jonathon Parkinson, Rodney Allan, Jonathon Ball, Nicholas Little
BACKGROUND: Spinal intradural arachnoid cysts (SIAC) are cerebrospinal fluid (CSF) filled sacs formed by arachnoid membranes and may be either idiopathic or acquired. Idiopathic cysts represent a separate entity and their aetiology remains uncertain. By far the most difficult differential diagnosis is distinguishing between idiopathic anterior spinal cord herniation (IASCH) and dorsal thoracic intradural arachnoid cysts (TIAC), due to their similarity in radiological appearance. Cine-mode (SSFP) is emerging as a novel technique in the diagnosis and operative planning of SIAC...
March 17, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28315802/upper-thoracic-versus-lower-thoracic-as-site-of-upper-instrumented-vertebrae-for-long-fusion-surgery-in-adult-spinal-deformity-a-meta-analysis-of-proximal-junctional-kyphosis
#3
Ming Luo, Pu Wang, Wengang Wang, Mingkui Shen, Genzhong Xu, Lei Xia
OBJECTIVE: A meta-analysis was performed to compare incidence rates of radiographic and surgical proximal junctional kyphosis (PJK) between upper thoracic (UT) versus lower thoracic (LT) as site of upper-instrumented vertebrae (UIV) endpoints for long fusion surgery in adult spinal deformity (ASD). METHODS: The MEDLINE, Embase, and the Cochrane Library databases were searched for English-language articles that addressed the UT versus LT fixation strategies. The division of the UT and LT groups was based on UIV...
March 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28306640/cervical-alignment-variations-in-different-postures-and-predictors-of-normal-cervical-kyphosis-a-new-understanding
#4
Hwee Weng Dennis Hey, Eugene Tze-Chun Lau, Chengyuan Gordon Wong, Kimberly-Anne Tan, Gabriel Ka-Po Liu, Hee-Kit Wong
STUDY DESIGN: Prospective comparative study OBJECTIVE.: To predict physiological alignment of the cervical spine and study its morphology in different postures. SUMMARY OF BACKGROUND DATA: There is increasing evidence that normal cervical spinal alignment may vary from lordosis to neutral to kyphosis, or form S-shaped or reverse S-shaped curves. METHODS: Standing, erect sitting and natural sitting whole spine radiographs were obtained from 26 consecutive patients without cervical spine pathology...
March 16, 2017: Spine
https://www.readbyqxmd.com/read/28301777/vertebral-body-compression-fractures-and-bone-density-automated-detection-and-classification-on-ct-images
#5
Joseph E Burns, Jianhua Yao, Ronald M Summers
Purpose To create and validate a computer system with which to detect, localize, and classify compression fractures and measure bone density of thoracic and lumbar vertebral bodies on computed tomographic (CT) images. Materials and Methods Institutional review board approval was obtained, and informed consent was waived in this HIPAA-compliant retrospective study. A CT study set of 150 patients (mean age, 73 years; age range, 55-96 years; 92 women, 58 men) with (n = 75) and without (n = 75) compression fractures was assembled...
March 16, 2017: Radiology
https://www.readbyqxmd.com/read/28299213/cervical-spinal-cord-compression-a-rare-presentation-of-hepatocellular-carcinoma
#6
Puvanalingam Ayyadurai, Kanthi Rekha Badipatla, Chukwunonso Chime, Shiva Arjun, Pavithra Reddy, Masooma Niazi, Suresh Kumar Nayudu
Hepatocellular carcinoma (HCC) is the most common primary malignancy of liver. Distant metastasis to various organs is well known. Skeletal metastasis is also reported to various locations. Vertebral metastasis has been reported mostly to thoracic spine. However, cervical spinal cord involvement leading to cord compression has been reported very rarely in literature. We present a case of 58-year-old male with liver cirrhosis presenting as neck pain. Further work-up revealed metastatic HCC to cervical spinal cord resulting in acute cord compression...
2017: Case Reports in Hepatology
https://www.readbyqxmd.com/read/28291927/single-fraction-radiosurgery-stereotactic-body-radiation-therapy-sbrt-for-spine-metastasis-a-dosimetric-comparison-of-multiple-delivery-platforms
#7
Adrian Nalichowski, Isaac Kaufman, John Gallo, Todd Bossenberger, Tim Solberg, Ezequiel Ramirez, Yulong Yan, Julie Fredrick, Tewfik Bichay, Alan Mayville, Jay Burmeister
There are numerous commercial radiotherapy systems capable of delivering single fraction spine radiosurgery/SBRT. We aim to compare the capabilities of several of these systems to deliver this treatment when following standardized criteria from a national protocol. Four distinct target lesions representing various case presentations of spine metastases were contoured in both the thoracic and lumbar spine of an anthropomorphic SBRT phantom. Single fraction radiosurgery/SBRT plans were designed for each target with each of our treatment platforms...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28290135/spinal-cord-injury-impairs-neurogenesis-and-induces-glial-reactivity-in-the-hippocampus
#8
Ignacio Jure, Luciana Pietranera, Alejandro F De Nicola, Florencia Labombarda
The incorporation of newborn neurons with increased synaptic remodeling and activity-dependent plasticity in the dentate gyrus enhances hippocampal-dependent learning performances. Astrocytes and microglial cells are components of the neurogenic niche and regulate neurogenesis under normal and neurophatological conditions leading to functional consequences for learning and memory. Although cognitive impairments were reported in patients after spinal cord injury (SCI), only few studies have considered remote changes in brain structures which are not related with sensory and motor cortex...
March 13, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28289632/hemodynamic-adaptations-to-regular-exercise-in-people-with-spinal-cord-injury
#9
Young Hee Lee, Jin Hyeong Lee, Sung Hoon Kim, Dongsoo Yi, Kyung Joon Oh, Ji Hyun Kim, Tae Jun Park, Hanul Kim, Jae Seung Chang, In Deok Kong
OBJECTIVE: To investigate the real-time cardiovascular response to the progressive overload exercise in different levels of spinal cord injury (SCI), and to find out whether regular exercise has effect on these cardiovascular responses. METHODS: The study enrolled 8 able-bodied individuals in the control group plus 15 SCI subjects who were divided into two groups by their neurological level of injury: high-level SCI group (T6 or above) and low-level SCI group (T7 or below)...
February 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28288900/the-mechanism-of-back-pain-relief-by-spinal-manipulation-relies-on-decreased-temporal-summation-of-pain
#10
Christopher Randoll, Vincent Gagnon-Normandin, Jessica Tessier, Suzie Bois, Nabi Rustamov, Julie O'Shaughnessy, Martin Descarreaux, Mathieu Piché
The aim of the present study was to determine whether thoracic spinal manipulation (SM) decreases temporal summation of back pain. The study comprised 2 controlled experiments including 16 and 15 healthy participants, respectively. Each study included 6 sessions during which painful or non-painful electrical stimulations were delivered in three conditions: 1) control 2) light mechanical stimulus (MS) or 3) SM. Electrical stimulation was applied on the thoracic spine (T4), in the area where SM and MS were performed...
March 10, 2017: Neuroscience
https://www.readbyqxmd.com/read/28288466/quantitative-assessment-of-trunk-muscles-involvement-in-patients-with-myotonic-dystrophy-type-1-using-a-whole-body-muscle-magnetic-resonance-imaging
#11
Donghwi Park, Jin-Sung Park
OBJECTIVE: The aim of this study was to analyze the pattern of trunk muscles involvement through a muscle MRI, in relation to the clinical data of patients diagnosed with myotonic dystrophy type 1 (DM1). MATERIALS AND METHODS: Patients with DM1 who visited the neurology department were enrolled (n = 19). In all patients, the fatty degeneration of the muscle MRI in the lower cervical, upper thoracic, middle thoracic, and lumbosacral spine extensor muscle group and trunk flexor muscle group was evaluated...
March 14, 2017: European Neurology
https://www.readbyqxmd.com/read/28286275/spontaneous-pyogenic-spondylodiscitis-in-the-thoracic-or-lumbar-spine-a-retrospective-cohort-study-comparing-the-safety-and-efficacy-of-minimally-invasive-and-open-surgery-over-a-nine-year-period
#12
Lennart Viezens, Christian Schaefer, Rachel Helmers, Eik Vettorazzi, Malte Schroeder, Nils Hansen-Algenstaedt
PURPOSE: Pyogenic spondylodiscitis is a rare disease, but its incidence is increasing. Over the last decade, spinal surgery has been modified to become minimally invasive. In degenerative spinal disorders, such minimally invasive surgery (MIS) reduces blood loss, muscular trauma and the hospital stay. However, it is not known whether MIS also confers these benefits to patients with pyogenic spondylodiscitis. This retrospective cohort study compared the safety and efficacy of minimally invasive surgery (MIS) and the conventional open surgical procedure in patients with pyogenic spondylodiscitis...
March 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28283082/effects-of-the-rider-on-the-kinematics-of-the-equine-spine-under-the-saddle-during-the-trot-using-inertial-measurement-units-methodological-study-and-preliminary-results
#13
P Martin, L Cheze, P Pourcelot, L Desquilbet, L Duray, H Chateau
Many factors associated with the saddle and the rider could produce pain in horses thus reducing performance. However, studies of horse-saddle-rider interactions are limited and determining their effects remains challenging. The aim of this study was to test a novel method for assessing equine thoracic and lumbar spinal movement under the saddle and collect data during trotting. Back movement was measured using inertial measurement units (n = 5) fixed at the levels of thoracic vertebrae T6, T12 and T16, and lumbar vertebrae L2 and L5...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28283076/prevalence-of-thoracic-vertebral-malformations-in-french-bulldogs-pugs-and-english-bulldogs-with-and-without-associated-neurological-deficits
#14
R Ryan, R Gutierrez-Quintana, G Ter Haar, Steven De Decker
Congenital vertebral malformations are common incidental findings in small breed dogs. This retrospective observational study evaluated the type and prevalence of thoracic vertebral malformations in 171 neurologically normal and 10 neurologically abnormal screw-tailed brachycephalic dogs. Neurologically normal dogs underwent CT for reasons unrelated to spinal disease, while affected dogs underwent MRI. Imaging studies were reviewed and vertebral malformations including hemivertebrae, block vertebrae, transitional vertebrae, and spina bifida were documented...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28282990/validation-and-accuracy-of-intraoperative-ct-scan-using-the-philips-alluraxper-fd20-angiography-suite-for-assessment-of-spinal-instrumentation
#15
Edin Nevzati, Javier Fandino, Bawarjan Schatlo, Michel Heimberg, Serge Marbacher, Luca Remonda, Ali-Reza Fathi
BACKGROUND: With the concept of the hybrid operating room gaining popularity, the authors adapted a hybrid angiographic suite with intraoperative computed tomography (iCT) to evaluate accuracy of pedicle screw placement in spinal fusion. This retrospective review examines how well iCT detected extrapedicular screw violation, to then allow repositioning and potentially avoid revision surgery. METHODS: A total of 36 consecutive patients underwent pedicle screw placement in posterior cervical, thoracic, and lumbosacral spinal fusions...
March 10, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28276661/anterior-lumbar-interbody-fusion-in-left-sided-inferior-vena-cava-and-right-sided-aortic-arch
#16
Kevin Phan, Bernard A M Fang, Monish M Maharaj, Andrew F Lennox, Ralph J Mobbs
Spinal fusion via anterior lumbar interbody fusion (ALIF) can offer symptomatic relief to patients that suffer severe low back pain, radiculopathy, and claudication. However, a detailed working knowledge of the thoracic, abdominal, and lumbar anatomy, particularly of the vasculature, is vital. We report the case of a 68-year-old man who presented with radiculopathy and progressively worsening low back pain despite 9 months of unsuccessful conservative therapy and pain management. Preoperative computed tomography and magnetic resonance imaging revealed a rare anatomical variation, with an anomalous left-sided inferior vena cava and anomalous aorta...
March 9, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28275813/osteochondroma-mimicking-meningioma-case-report-and-literature-update
#17
Ashwath J Sampath, Douglas C Miller, Fassil B Mesfin, Julia R Crim
We report a case of an osteochondroma in a 47-year-old woman presenting with a 2-month history of thoracic back pain that radiated down her left arm. Based on imaging features, the osteochondroma was initially thought to represent a calcified meningioma. The unusual features of the case include the location of the tumor, patient age, the erosion of the vertebra, and the confusing neuroradiological features. We review reported cases in which a solitary costal osteochondroma impinges on the neural foramina or central spinal canal and we discuss reasons for the misdiagnosis in our case...
March 8, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28274487/manipulation-peak-forces-across-spinal-regions-for-children-using-mannequin-simulators
#18
John J Triano, Steven Lester, David Starmer, Elise G Hewitt
OBJECTIVE: The purpose of this work was to create an exploratory database of manipulation treatment force variability as a function of the intent of an experienced clinician sub-specializing in the care of children to match treatment to childhood category. Data of this type are necessary for realistic planning of dose-response and safety studies on therapeutic benefit. METHODS: The project evaluated the transmitted peak forces of procedures applied to mannequins of different stature for younger and older children...
March 5, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28274020/role-of-cross-sectional-imaging-in-isolated-chest-wall-tuberculosis
#19
Deb Kumar Boruah, Shantiranjan Sanyal, Barun K Sharma, Arjun Prakash, Dhabal D Dhingani, Karobi Bora
INTRODUCTION: Isolated chest wall tuberculosis though a rare entity, the incidence of it has been on rise among immunocompromised population making it an important challenging diagnosis for the physicians. Its clinical presentation may resemble pyogenic chest wall abscess or chest wall soft tissue tumour. Sometimes it is difficult to detect clinically or on plain radiograph. AIM: The present study was conducted with an aim to evaluate the common sites and varying appearances of isolated chest wall tuberculosis...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28272292/the-erector-spinae-plane-block-provides-visceral-abdominal-analgesia-in-bariatric-surgery-a-report-of-3-cases
#20
Ki Jinn Chin, Laith Malhas, Anahi Perlas
Postoperative pain after bariatric surgery can be significant and yet difficult to manage. These patients frequently have associated obstructive sleep apnea and are at risk of respiratory depression with opioid analgesia. Abdominal wall blocks such as the subcostal transversus abdominis plane block are not of significant benefit, probably in part because they provide only somatic analgesia. The ultrasound-guided erector spinae plane (ESP) block is a recently described regional anesthetic technique for providing thoracic analgesia when performed at the level of the T5 transverse process...
March 8, 2017: Regional Anesthesia and Pain Medicine
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