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https://www.readbyqxmd.com/read/29239336/neural-progenitor-cells-but-not-astrocytes-respond-distally-to-thoracic-spinal-cord-injury-in-rat-models
#1
Tara Nguyen, Yilin Mao, Theresa Sutherland, Catherine Anne Gorrie
Traumatic spinal cord injury (SCI) is a detrimental condition that causes loss of sensory and motor function in an individual. Many complex secondary injury cascades occur after SCI and they offer great potential for therapeutic targeting. In this study, we investigated the response of endogenous neural progenitor cells, astrocytes, and microglia to a localized thoracic SCI throughout the neuroaxis. Twenty-five adult female Sprague-Dawley rats underwent mild-contusion thoracic SCI (n = 9), sham surgery (n = 8), or no surgery (n = 8)...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29238648/trends-in-spinal-surgery-for-pott-s-disease-2000-2016-an-overview-and-bibliometric-study
#2
Christian Fisahn, Fernando Alonso, Ghazwan A Hasan, R Shane Tubbs, Joseph R Dettori, Thomas A Schildhauer, Tarush Rustagi
Study Design: Systematic review. Objectives: (1) What are the surgical indications? Have they changed over time since the year 2000? (2) What is the current surgical approaches of choice? Have they changed over time since the year 2000? Do they vary by geographical region? (3) What are the most common outcome measures following surgery? Methods: Electronic databases and reference lists of key articles were searched from database inception from January 1, 2000 to December 31, 2016 to identify studies specifically evaluating surgical indications, current surgical approaches, and outcome measures for spinal tuberculosis...
December 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29238292/effect-of-vegf-on-inflammatory-regulation-neural-survival-and-functional-improvement-in-rats-following-a-complete-spinal-cord-transection
#3
Jing Li, Shuangxi Chen, Zhikai Zhao, Yunhao Luo, Yuhui Hou, Heng Li, Liumin He, Libing Zhou, Wutian Wu
After complete transection of the thoracic spinal segment, neonatal rats exhibit spontaneous locomotor recovery of hindlimbs, but this recovery is not found in adult rats after similar injury. The potential mechanism related to the difference in recovery of neonatal and adult rats remains unknown. In this study, 342 animals were analyzed. The vascular endothelial growth factor (VEGF) level in spinal segments below injury sites was significantly higher in postnatal day 1 rats (P1) compared with 28-day-old adult rats (P28) following a complete T9 transection...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29236577/a-focal-cooling-method-for-the-cervical-spinal-cord-a-percutaneous-approach-to-the-dorsal-neck-in-dogs
#4
Kanichiro Kaneko, Yasuharu Noishiki, Kengo Funakoshi, Tomoyuki Saito
For the treatment of acute cervical spinal cord injuries, a local epidural cooling system using a percutaneous technique was proposed. In this animal study, regional low temperature was obtained stably in the cervical epidural space (CED) without decreasing temperatures at the rectum and the thoracic epidural space. Three stainless steel tubes were inserted percutaneously using the lateral approach into 3 serial interspinous spaces of the neck of 12 beagles under radiographic guidance. Two temperature probes were inserted into the CEDs at the level of the middle cooling tube...
December 13, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/29235939/are-shoulder-counter-rotation-and-hip-shoulder-separation-angle-representative-metrics-of-three-dimensional-spinal-kinematics-in-cricket-fast-bowling
#5
Billy Senington, Raymond Y Lee, Jonathan Mark Williams
This study aimed to investigate the relationship between shoulder counter-rotation (SCR), hip shoulder separation (HSS) and three-dimensional spinal kinematics during fast bowling in cricket. Thirty five elite male fast bowlers were analysed using three-dimensional inertial sensors on the spine. Lumbar, thoracic and thoracolumbar kinematics were determined during the delivery stride. Spearman's pairwise correlations displayed significant associations between SCR, thoracic and thoracolumbar lateral flexion between the back foot impact and max contralateral rotation phase of the delivery stride (rs = -...
December 13, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29234883/accuracy-of-thoracic-pedicle-screw-placement-in-adolescent-patients-with-severe-spinal-deformities-a-retrospective-study-comparing-drill-guide-template-with-free-hand-technique
#6
Yue Pan, G H Lü, Lei Kuang, Bing Wang
PURPOSE: Patients with severe spinal deformities often have small pedicle diameters, and pedicle dimensions vary between segments and individuals. Free-hand pedicle screw placement can be inaccurate. Individualized drill guide templates may be used, but the accuracy of pedicle screw placement in severe scoliosis remains unknown. The accuracy of drill guide templates and free-hand technique for the treatment of adolescent patients with severe idiopathic scoliosis are compared in this study...
December 12, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29233724/caprine-neonatal-spinal-ultrasonography
#7
Elham A Hassan, Khaled M Ali, Faisal A Torad
Spinal ultrasonography is a safe, rapid, and non-invasive diagnostic tool that allows visualization of the spinal cord and its surrounding meninges. The non-ossified spinous processes were used as an acoustic window for imaging the spinal cord in human and canine neonates. No available literatures have been published describing the ultrasonographic appearance of caprine neonatal spinal cord. The present study was performed on 20 one day-old goat kids. Sagittal and transverse ultrasound scans were obtained using 8MHz linear transducer...
December 9, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29232355/proximal-junctional-kyphosis-inter-and-intraobserver-reliability-of-radiographic-measurements-in-adult-spinal-deformity
#8
Farbod Rastegar, Alec Contag, Alan Daniels, Jayme Hiratzka, Clifford Lin, Jason Chang, Khoi Than, Ahmed Raslan, Christopher Kong, Ngoc-Lam Nguyen, Richard Hostin, Marie Kane, Robert A Hart
STUDY DESIGN: Reliability study of radiographic measures of proximal junctional kyphosis (PJK) in patients with adult spinal deformity (ASD). OBJECTIVE: To assess impacts of level of proximal endpoint and vertebral fracture on reliability of measurement of junctional kyphosis. SUMMARY OF BACKGROUND DATA: Radiographic assessment is important in determining management of patients with PJK or proximal junctional failure (PJF). No study to date has evaluated the reliability of radiographic measurement of the junctional kyphotic angle after surgery for ASD...
January 1, 2018: Spine
https://www.readbyqxmd.com/read/29230608/combinatorial-therapy-with-two-pro-coagulants-and-one-osmotic-agent-reduces-the-extent-of-the-lesion-in-the-acute-phase-of-spinal-cord-injury-in-the-rat
#9
Mathieu Boutonnet, Elisabeth Laemmel, Eric Vicaut, Jacques Duranteau, Marc Soubeyrand
BACKGROUND: Spinal cord injury (SCI) is a complex disease that leads to a motor, sensitive, and vegetative impairment. So far, single therapies are ineffective for treating SCI in humans and a multifactorial therapeutic approach may be required. The aim of this work was to assess the effect of a triple therapy (TT) associating two pro-coagulant therapies (tranexamic acid and fibrinogen) with an anti-edema therapy (hypertonic saline solution), on the extent of the lesion 24 h post-injury...
December 11, 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/29230488/surgical-treatment-of-compressive-spinal-hemangioma-a%C3%A2-case-series-of-three-patients-and-literature-review
#10
Yun-Lin Chen, Xu-Dong Hu, Nan-Jian Xu, Wei-Yu Jiang, Wei-Hu Ma
PURPOSE: In this article we describe the treatment of compressive vertebral hemangioma. METHODS: Our case series comprised three patients with aggressive hemangioma. We performed a combination of posterior decompression and vertebroplasty for the two patients with a sacral hemangioma and a thoracic hemangioma, and en bloc resection for the third patient, who also had a thoracic lesion. RESULTS: Surgical intervention is indicated in cases of rapidly progressive tumors or severe myelopathy...
December 11, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/29229509/diagnosis-of-congenital-abnormalities-with-post-mortem-ultrasound-in-perinatal-death
#11
L Tuchtan, E Lesieur, C Bartoli, C Delteil, L Sarda-Quarello, J Torrents, S Sigaudy, M-D Piercecchi, G Gorincour
PURPOSE: To determine the sensitivity and specificity of post-mortem ultrasound in the diagnosis of major congenital abnormalities of fetuses using conventional autopsy as the standard of reference. MATERIAL AND METHODS: All fetuses coming from terminations of pregnancy or intrauterine fetal deaths in a single institution were included. A total of 75 fetuses were included during the study period. The results of post-mortem ultrasound examinations were compared to those of conventional autopsy that served as standard of reference...
December 8, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29229351/evaluation-of-the-measuring-methods-of-the-spinal-canal-occupation-rate-in-thoracic-ossification-of-ligamentum-flavum
#12
Sheng-Yuan Zhou, Bo Yuan, Chuang Qian, Xiong-Sheng Chen, Lian-Shun Jia
OBJECTIVE: The degree of hypertrophy of thoracic ossification of ligamentum flavum (TOLF) is related to the severity of the myelopathy. There is no uniform measuring method to calculate the spinal canal occupation ratio (COR) of TOLF simply and effectively. The study was to determine an appropriate measuring method to calculate the COR of TOLF. METHODS: A total of 37 computerized tomography (CT) cross-sectional imaging scans (bone window) from 22 patients were analyzed retrospectively in this study...
December 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29229061/accuracy-of-a-radiological-evaluation-method-for-thoracic-and-lumbar-spinal-curvatures-using-spinous-processes
#13
Bárbara V Marchetti, Cláudia T Candotti, Eduardo G Raupp, Eduardo B C Oliveira, Tássia S Furlanetto, Jefferson F Loss
OBJECTIVE: The purpose of this study was to assess a radiographic method for spinal curvature evaluation in children, based on spinous processes, and identify its normality limits. METHODS: The sample consisted of 90 radiographic examinations of the spines of children in the sagittal plane. Thoracic and lumbar curvatures were evaluated using angular (apex angle [AA]) and linear (sagittal arrow [SA]) measurements based on the spinous processes. The same curvatures were also evaluated using the Cobb angle (CA) method, which is considered the gold standard...
November 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29229060/development-and-validation-of-prediction-equations-for-spinal-curve-angles-based-on-skin-surface-measurements
#14
Tássia S Furlanetto, Eduardo B C de Oliveira, Cláudia T Candotti, Adriane Vieira, Paula V de Mesquita, Isis J R L Navarro, Jefferson F Loss
OBJECTIVE: The purpose of this study was to develop, assess the reliability of, and validate prediction equations that estimate the sagittal curves of the spine from the skin surface. METHODS: Forty digital panoramic radiographs were used to develop the prediction equation, and 59 radiographs were used to assess reliability and validate the equations. For evaluation of the thoracic and lumbar curves, anatomical reference points were marked on the vertebral body, spinous process, and skin surface at the C6, C7, T2, T4, T6, T8, T10, T12, L2, L4, and S2 vertebrae...
November 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29229059/the-reliability-of-standing-sagittal-measurements-of-spinal-curvature-and-range-of-motion-in-older-women-with-and-without-hyperkyphosis-using-a-skin-surface-device
#15
Tayebeh Roghani, Minoo Khalkhali Zavieh, Abbas Rahimi, Saeed Talebian, Farideh Dehghan Manshadi, Alireza Akbarzadeh Baghban, Nicole King, Wendy Katzman
OBJECTIVE: The purpose of this study was to investigate the intrarater reliability of a skin-surface instrument (Spinal Mouse, Idiag, Voletswil, Switzerland) in measuring standing sagittal curvature and global mobility of the spine in older women with and without hyperkyphosis. METHODS: Measurements were made in 19 women with hyperkyphosis (thoracic kyphosis angle ≥50°), mean age 67 ± 5 years, and 14 women without hyperkyphosis (thoracic kyphosis angle <50°), mean age 63 ± 6 years...
November 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29225127/case-report-simultaneous-endovascular-repair-of-a-thoracic-aortic-injury-during-posterior-pedicle-screw-removal
#16
Serena Martin, Richard Lindsay, Robin C Baker
INTRODUCTION: Posterior spinal stabilisation is a technically demanding procedure which is increasing in popularity. Since this increase in popularity, complications, including screws misplacement, are being highlighted. Accuracy rates are higher when imaging modalities are used intra-operatively. Vascular injuries following posterior spinal stabilisation are rare and are usually discovered late on subsequent imaging. Immediate peri-operative compromise is rare, but nonetheless, resultant vascular injuries can be life threatening...
December 7, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29225115/thoracic-disc-herniation-surgical-treatment
#17
REVIEW
C Court, E Mansour, C Bouthors
Thoracic disc herniation is rare and mainly occurs between T8 and L1. The herniation is calcified in 40% of cases and is labelled as giant when it occupies more than 40% of the spinal canal.A surgical procedure is indicated when the patient has severe back pain, stubborn intercostal neuralgia or neurological deficits. Selection of the surgical approach is essential. Midline calcified hernias are approached from a transthoracic incision, while lateralized soft hernias can be approached from a posterolateral incision...
December 7, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29224696/spinal-pain-and-its-impact-on-older-people
#18
REVIEW
Manuela L Ferreira, Katie de Luca
The term 'spinal pain' collectively includes the cervical, thoracic and lumbosacral regions of the spine. The majority of older people experience spinal pain, and with an increasing proportion of older people, the prevalence of spinal conditions are expected to increase in the coming decades. Musculoskeletal conditions of the spine in the older patient commonly include osteoarthritis and spinal stenosis, and the result of these degenerative diseases includes pain, stiffness and a decreased ability to engage in everyday activities...
April 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29223322/systemic-administration-of-epothilone-d-improves-functional-recovery-of-walking-after-rat-spinal-cord-contusion-injury
#19
Jörg Ruschel, Frank Bradke
Central nervous system (CNS) injuries cause permanent impairments of sensorimotor functions as mature neurons fail to regenerate their severed axons. The poor intrinsic growth capacity of adult CNS neurons and the formation of an inhibitory lesion scar are key impediments to axon regeneration. Systemic administration of the microtubule stabilizing agent epothilone B promotes axon regeneration and recovery of motor function by activating the intrinsic axonal growth machinery and by reducing the inhibitory fibrotic lesion scar...
December 6, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29219779/metastases-of-spinal-myxopapillary-ependymoma-unique-characteristics-and-clinical-management
#20
Theresa Kraetzig, Lily McLaughlin, Mark H Bilsky, Ilya Laufer
OBJECTIVE Myxopapillary ependymoma is a benign WHO Grade I tumor most commonly located in the conus-cauda equina region of the spine. Although this tumor is defined by an overall excellent survival, dissemination throughout the whole neuraxis occurs frequently. The current study evaluated the clinical characteristics and significance of myxopapillary ependymoma metastases. METHODS Patients who underwent surgery from 2005 to 2015 for treatment of spinal myxopapillary ependymoma were included in the study. Charts were reviewed for primary tumor symptoms and initial treatment, local recurrence, response to salvage therapy, and presence and behavior of distant metastases...
December 8, 2017: Journal of Neurosurgery. Spine
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