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https://www.readbyqxmd.com/read/29934690/knockdown-of-microrna-21-promotes-neurological-recovery-after-acute-spinal-cord-injury
#1
Wei Xie, Shang-You Yang, Qianqian Zhang, Yadong Zhou, Yi Wang, Ronghan Liu, Wenzhao Wang, Jixue Shi, Bin Ning, Tanghong Jia
To assess the therapeutic effects of microRNA-21 (miR-21) knockdown (KD) for acute thoracic spinal cord contusion using a mouse model. Forty C57/BL6 mice were randomly divided into four groups: mice in the sham-operated (Sham) group received surgical procedure without spinal cord contusion; the spinal cord injury (SCI) group mice underwent spinal cord contusion without treatment; mice in the miR-21 KD group underwent spinal cord contusion followed by a single dose subdural injection of miR-21 KD vectors (1 × 107 TU); and the negative control (NC) group mice were given subdural injection of comparable amount of NC vectors (1 × 107 TU) after spinal cord contusion...
June 22, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29933334/spinal-injuries-in-suicidal-jumpers
#2
Hiroki Kano, Yohei Matsuo, Noriaki Kubo, Satoshi Fujimi, Takashi Nishiii
STUDY DESIGN: This was a retrospective case series at a single institution. OBJECTIVE: The study was performed to investigate the characteristics of spinal injuries in survivors of suicidal jumping. SUMMARY OF BACKGROUND DATA: Spinal fracture/dislocation is associated with high-energy trauma such as that induced by motor vehicle accidents. Survivors of suicidal jumping sometimes sustain spinal injuries. However, the characteristics of such spinal injuries are unclear...
June 21, 2018: Spine
https://www.readbyqxmd.com/read/29930879/management-of-autonomic-dysreflexia-associated-with-charcot-spinal-arthropathy-in-a-patient-with-complete-spinal-cord-injury-case-report-and-review-of-the-literature
#3
Justin L Gibson, Shawn M Vuong, Robert J Bohinski
Background: Charcot spinal arthropathy (CSA) clearly represents a challenge in long-term spinal cord injury patients, one that can have extremely uncomfortable and potentially lethal outcomes if not managed properly. Case Description: A 66-year-old man with a history of complete C7 quadriplegia presented with new-onset autonomic dysreflexia that resulted from Charcot spinal arthropathy (CSA). Pathologic instability, in the atypical site of the mid-thoracic spine, spanning from the T8-T9 vertebral levels was appreciated on physical exam as an audible, palpable, and visible dynamic kyphosis; kyphosis was later confirmed on neuroimaging...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29929554/a-difficult-situation-balancing-critical-anticoagulation-versus-the-risk-of-permanent-neurologic-deficit-a-case-report
#4
Girard Cua, Neal Holland, Ashleigh Wright
BACKGROUND: Anticoagulation is the mainstay of treatment for pulmonary embolism. However, if bleeding unfortunately occurs, the risks and benefits of anticoagulation present a challenge. Management of one hemorrhagic complication, retroperitoneal hematoma, is rare, difficult, and controversial. CASE PRESENTATION: A 73-year-old white man presented with left lower extremity swelling and dyspnea. He was tachycardic, hypertensive, and demonstrated poor oxygen saturation of 81% on ambient air...
June 22, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29929033/central-herniation-induced-by-craniotomy-prompting-air-replacement-for-subdural-fluid-collection-due-to-cerebrospinal-fluid-hypovolemia-a-case-report
#5
Takahide Haku, Yasushi Motoyama, Yoshiaki Takamura, Shuichi Yamada, Ichiro Nakagawa, Young-Su Park, Hiroyuki Nakase
BACKGROUND: Chronic subdural hematoma (CSDH) often occurs in association with cerebrospinal fluid (CSF) hypovolemia. Many cases with CSDH due to CSF hypovolemia and treated by burr-hole surgery have been reported to present with paradoxical deterioration. However, the mechanisms and pathology of deterioration after surgery for CSDH due to CSF hypovolemia remain obscure. CASE DESCRIPTION: We report herein a 62-year-old man with gait disturbance due to subdural fluid collection (SDFC) who underwent burr-hole irrigation and additional craniotomy, in which postoperative deterioration resulted from rapidly progressing central herniation with large amount of air accumulation...
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29928513/characterization-of-spinal-cord-diffusion-tensor-imaging-metrics-in-clinically-asymptomatic-pediatric-subjects-with-incidental-congenital-lesions
#6
Sona Saksena, Mahdi Alizadeh, Devon M Middleton, Chris J Conklin, Laura Krisa, Adam Flanders, M J Mulcahey, Feroze B Mohamed, Scott H Faro
Study design: Retrospective study. Objectives: To perform quantitative DTI measurements of the entire cervical and thoracic spinal cord (SC) in typically developing (TD) pediatric subjects with incidental findings of syringomyelia or hydromyelia on conventional MRI and in a TD population without any abnormalities. Setting: USA. Methods: 26 TD recruited as part of large SC DTI study, four of these had incidental findings...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29927859/preoperative-sagittal-spinal-profile-of-adolescent-idiopathic-scoliosis-lenke-types-and-non-scoliotic-adolescents-a-systematic-review-and-meta-analysis
#7
Saba Pasha, Keith Baldwin
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: This study aims to determine the differences in sagittal spinopelvic parameters between adolescent idiopathic scoliosis (AIS) Lenke types and non-scoliotic controls through a systematic review and meta-analysis of the available literature. SUMMARY OF BACKGROUND DATA: AIS classification mainly focuses on frontal curve differences; however, the variations in the sagittal spinopelvic alignment in the current classification system is not fully established...
June 20, 2018: Spine
https://www.readbyqxmd.com/read/29923798/the-lifetime-cost-of-spinal-cord-injury-in-ontario-canada-a-population-based-study-from-the-perspective-of-the-public-health-care-payer
#8
Brian Chun-Fai Chan, Suzanne M Cadarette, Walter P Wodchis, Murray D Krahn, Nicole Mittmann
OBJECTIVE: To determine the publicly funded health care system lifetime cost-of-illness of spinal cord injury (SCI) from the perspective of the Ontario Ministry of Health and Long-term Care. METHODS: Individuals hospitalized for their first SCI between the years 2005 and 2011 were identified and their health care costs were calculated using Ontario administrative health care data. From this information, lifetime costs were estimated using phase-based costing methods...
June 20, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29920605/extended-asymmetrical-pedicle-subtraction-osteotomy-for-adult-spinal-deformity-2-dimensional-operative-video
#9
Thomas J Buell, Avery L Buchholz, John C Quinn, Jeffrey P Mullin, Juanita Garces, Marcus D Mazur, Mark E Shaffrey, Chun-Po Yen, Christopher I Shaffrey, Justin S Smith
Pedicle subtraction osteotomy (PSO) is an effective technique to correct fixed sagittal malalignment. A variation of this technique, the "trans-discal" or "extended" PSO (Schwab grade IV osteotomy), involves extending the posterior wedge resection of the index vertebra to include the superior adjacent disc for radical discectomy. The posterior wedge may be resected in asymmetric fashion to correct concurrent global coronal malalignment.This video illustrates the technical nuances of an extended asymmetrical lumbar PSO for adult spinal deformity...
June 16, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29920395/clinical-and-radiographic-results-after-posterior-wedge-osteotomy-for-thoracolumbar-kyphosis-secondary-to-ankylosing-spondylitis-comparison-of-long-and-short-segment-instrumentation
#10
Mu Qiao, Bang-Ping Qian, Shi-Zhou Zhao, Yong Qiu, Bin Wang, Jun Jiang
OBJECTIVE: To compare the efficacy of long and short segment instrumentation following pedicle subtraction osteotomy (PSO) for thoracolumbar kyphosis caused by ankylosing spondylitis (AS). METHODS: Sixty-four consecutive AS patients were analyzed and divided into groups according to length of instrumentation. We defined short segment instrumentation (SSI) as construct length less than 7 levels (3 levels above and below the osteotomy or less) (n=17). In contrast, long segment instrumentation (LSI) was defined as construct length equal to or greater than 7 levels (4 levels above and 3 levels below the osteotomy or more) (n=47)...
June 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29917121/new-insights-into-spinal-cord-ischaemia-after-thoracic-aortic-procedures-the-importance-of-the-number-of-anterior-radiculomedullary-arteries-for-surgical-outcome
#11
Fabian A Kari, Babak Saravi, Sonja Krause, Luisa Puttfarcken, Johannes Scheumann, Katharina Förster, Bartosz Rylski, Sven Maier, Ulrich Göbel, Matthias Siepe, Martin Czerny, Friedhelm Beyersdorf
OBJECTIVES: Anterior radiculomedullary arteries (ARMAs) link dorsal segmental arteries and the intraspinal compartment of the spinal collateral network. The number of thoracic ARMA is highly variable from one person to another. The impact of the number of ARMAs on spinal cord perfusion during thoracic aortic procedures is unknown. We investigated the influence of the number of thoracic ARMAs on spinal cord perfusion in an aortic surgical large animal model. METHODS: Twenty-six pigs were included (20 treatment animals, 6 sham animals, weight 34 ± 3 kg)...
July 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29913936/a-systematic-review-of-comparative-studies-indicates-that-paravertebral-block-is-neither-superior-nor-safer-than-epidural-analgesia-for-pain-after-thoracotomy
#12
Hilde M Norum, Harald Breivik
Background The "gold standard" for pain relief after thoracotomy has been thoracic epidural analgesia (TEA). The studies comparing TEA with paravertebral block (PVB) and recent reviews recommend PVB as a novel, safer method than TEA. Methods A systematic search of the Cochrane and PubMed databases for prospective, randomized trials (RCTs) comparing TEA and PVB for post-thoracotomy analgesia was done. We assessed how TEA and PVB were performed, methods of randomization, assessment of pain relief, and complications...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29912905/factors-influencing-spinal-curvature-measurements-on-ultrasound-images-for-children-with-adolescent-idiopathic-scoliosis-ais
#13
Rui Zheng, Doug Hill, Douglas Hedden, James Mahood, Marc Moreau, Sarah Southon, Edmond Lou
The measurements of spinal curvatures using the ultrasound (US) imaging method on children with scoliosis have been comparable with radiography. However, factors influencing the reliability and accuracy of US measurement have not been studied. The purpose of this study is to investigate the effects of curve features and patients' demographics on US measurements and to determine which factors influence the reliability and accuracy. Two hundred children with scoliosis were recruited and scanned with US by one experienced operator and three trainees...
2018: PloS One
https://www.readbyqxmd.com/read/29911402/the-effects-of-rotation-on-radiological-parameters-in-the-spine
#14
Christian Wong, Johanna Hall, Kasper Gosvig
Background Vertebral rotation in straight spines or in spines with small scoliosis may potentially affect measurement of radiological parameters in both the frontal and sagittal plane. This is important, since it could lead to potential misdiagnosis of scoliosis and other clinical consequences, and until now, this has not been examined. Purpose To examine the effect of axial vertebral rotation of the spine on measurement of common radiological parameters. Material and Methods Reconstructions from computed tomography scans of 40 consecutive included and anonymized patients with straight spines or small scoliosis...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29910637/combined-microwave-ablation-and-minimally-invasive-open-decompression-for-the-management-of-thoracic-metastasis-in-breast-cancer
#15
Bin Liu, Zhenchao Yuan, Chang Yuan Wei
Objective: The incidence rate of thoracic metastasis from breast cancer is increasing. Microwave ablation is one type of clinical therapy used to treat metastatic spine disease, although it can cause protein denaturation and immediate cell death, and coagulative necrosis can occur. Minimally invasive open decompression is associated with lower rates of surgical complications in comparison to traditional open surgery. Therefore, it is an alternative therapeutic option for spinal metastases...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29906618/treatment-outcomes-of-17-patients-with-atypical-spinal-meningioma-including-4-with-metastases-a-retrospective-observational-study
#16
Sung Hyun Noh, Kyung Hyun Kim, Dong Ah Shin, Jeong Yoon Park, Seong Yi, Sung Uk Kuh, Keung Nyun Kim, Dong Kyu Chin, Keun Su Kim, Do Heum Yoon, Yong Eun Cho
BACKGROUND CONTEXT: Because of the scarcity of atypical spinal meningioma, there is a lack of research on this type of tumor or its associated metastases. PURPOSE: The aim of this study was to investigate the biological behavior of atypical spinal meningioma and identify its prognostic factors by reviewing surgical and clinical outcomes of patients with these tumors. STUDY DESIGN/SETTING: A retrospective chart review was performed. PATIENT SAMPLE: We retrospectively reviewed the data from all patients who underwent spinal cord tumor excision between 1994 and 2017...
June 12, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29906340/sympatho-excitatory-response-to-pulmonary-chemosensitive-spinal-afferent-activation-in-anesthetized-vagotomized-rats
#17
Julia Shanks, Zhiqiu Xia, Steven J Lisco, George J Rozanski, Harold D Schultz, Irving H Zucker, Han-Jun Wang
The sensory innervation of the lung is well known to be innervated by nerve fibers of both vagal and sympathetic origin. Although the vagal afferent innervation of the lung has been well characterized, less is known about physiological effects mediated by spinal sympathetic afferent fibers. We hypothesized that activation of sympathetic spinal afferent nerve fibers of the lung would result in an excitatory pressor reflex, similar to that previously characterized in the heart. In this study, we evaluated changes in renal sympathetic nerve activity (RSNA) and hemodynamics in response to activation of TRPV1-sensitive pulmonary spinal sensory fibers by agonist application to the visceral pleura of the lung and by administration into the primary bronchus in anesthetized, bilaterally vagotomized, adult Sprague-Dawley rats...
June 2018: Physiological Reports
https://www.readbyqxmd.com/read/29905897/patterns-of-injury-and-outcomes-in-the-elderly-patient-with-rib-fractures-a-multicenter-observational-study
#18
Mark G Van Vledder, Vicky Kwakernaak, Tjebbe Hagenaars, Esther M M Van Lieshout, Michiel H J Verhofstad
BACKGROUND: High rates of pneumonia and death have been reported among elderly patients with rib fractures. This study aims to identify patterns of injury and risk factors for pneumonia and death in elderly patients with rib fractures. METHODS: A retrospective multicenter observational study was performed using data registered in the national trauma registry between 2008 and 2015 in the South West Netherlands Trauma region. Data regarding demographics, mechanism of injury, pulmonary and cardiovascular history, pattern of extra-thoracic and intrathoracic injuries, ICU admission, length of stay, and morbidity and mortality following admission were collected...
June 15, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29905521/contrast-enhanced-ultrasound-to-visualize-hemodynamic-changes-after-rodent-spinal-cord-injury
#19
Zin Z Khaing, Lindsay N Cates, Dane M DeWees, Alexander Hannah, Pierre Mourad, Matthew Bruce, Christoph P Hofstetter
OBJECTIVE Traumatic spinal cord injury (tSCI) causes an almost complete loss of blood flow at the site of injury (primary injury) as well as significant hypoperfusion in the penumbra of the injury. Hypoperfusion in the penumbra progresses after injury to the spinal cord and is likely to be a major contributor to progressive cell death of spinal cord tissue that was initially viable (secondary injury). Neuroprotective treatment strategies seek to limit secondary injury. Clinical monitoring of the temporal and spatial patterns of blood flow within the contused spinal cord is currently not feasible...
June 15, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29905040/-promotion-of-transplanted-collagen-scaffolds-combined-with-brain-derived-neurotrophic-factor-for-axonal-regeneration-and-motor-function-recovery-in-rats-after-transected-spinal-cord-injury
#20
Xi Chen, Yongheng Fan, Zhifeng Xiao, Xing Li, Bin Yang, Yannan Zhao, Xianglin Hou, Sufang Han, Jianwu Dai
Objective: To evaluate the effect of the combination of collagen scaffold and brain-derived neurotrophic factor (BDNF) on the repair of transected spinal cord injury in rats. Methods: Thirty-two Sprague-Dawley rats were randomly divided into 4 groups: group A (sham operation group), T 9 , T 10 segments of the spinal cord was only exposed; group B, 4-mm T 9 , T 10 segments of the spinal cord were resected; group C, 4-mm T 9 , T 10 segments of the spinal cord were resected and linear ordered collagen scaffolds (LOCS) with corresponding length was transplanted into lesion site; group D, 4-mm T 9 , T 10 segments of the spinal cord were resected and LOCS with collagen binding domain (CBD)-BDNF was transplanted into lesion site...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
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