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https://www.readbyqxmd.com/read/29902085/immune-gene-therapy-and-the-international-conference-on-lymphocyte-engineering-icle-2018
#1
Adi Barzel
No abstract text is available yet for this article.
June 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29900525/norepinephrine-upregulates-volume-regulated-chloride-current-by-pka-independent-camp-epac-pathway-in-human-atrial-myocytes
#2
Guo-Sheng Xiao, Yan-Hui Zhang, Yan Wang, Hai-Ying Sun, Clive M Baumgarten, Gui-Rong Li
BACKGROUND AND PURPOSE: Adrenergic regulation of cell volume-regulated chloride current (ICl.vol ) is species-dependent. The present study investigates the mechanism underlying adrenergic regulation of ICl.vol in human atrial myocytes. EXPERIMENTAL APPROACH: A conventional whole-cell patch voltage-clamp technique was utilized to record membrane current in human atrial myocytes. ICl.vol was evoked by hyposmotic bath solution (0.6-times isosmotic, 0.6T). KEY RESULTS: ICl...
June 13, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29898694/refractive-outcomes-and-optical-quality-after-implantation-of-posterior-chamber-phakic-implantable-collamer-lens-with-a-central-hole-icl-v4c
#3
Huamao Miao, Xun Chen, Mi Tian, Yingjun Chen, Xiaoying Wang, Xingtao Zhou
BACKGROUND: To investigate refractive outcomes and optical quality after implantation of posterior chamber phakic implantable collamer lens with a central hole (ICL V4c) to correct high myopia. METHODS: Sixty seven eyes of 38 patients who underwent ICL V4c implantation were enrolled. The mean preoperative spherical equivalent (SE) was - 12.44 ± 3.15 D (range: - 6.63 to - 20.50 D). The refractive outcomes and optical quality of the eyes at postoperative 1 and 3 months were evaluated and compared...
June 14, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29895858/a-homozygous-fancm-frameshift-pathogenic-variant-causes-male-infertility
#4
Hao Yin, Hui Ma, Sajjad Hussain, Huan Zhang, Xuefeng Xie, Long Jiang, Xiaohua Jiang, Furhan Iqbal, Ihtisham Bukhari, Hanwei Jiang, Asim Ali, Liangwen Zhong, Tao Li, Suixing Fan, Beibei Zhang, Jianing Gao, Yang Li, Jabeen Nazish, Teka Khan, Manan Khan, Muhammad Zubair, Qiaomei Hao, Hui Fang, Jun Huang, Mahmoud Huleihel, Jiahao Sha, Tej K Pandita, Yuanwei Zhang, Qinghua Shi
PURPOSE: Fanconi anemia (FA) genes play important roles in spermatogenesis. In mice, disruption of Fancm impairs male fertility and testicular integrity, but whether FANCM pathogenic variants (PV) similarly affect fertility in men is unknown. Here we characterize a Pakistani family having three infertile brothers, two manifesting oligoasthenospermia and one exhibiting azoospermia, born to first-cousin parents. A homozygous PV in FANCM (c.1946_1958del, p.P648Lfs*16) was found cosegregating with male infertility...
June 12, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29891926/map-of-synthetic-rescue-interactions-for-the-fanconi-anemia-dna-repair-pathway-identifies-usp48
#5
Georgia Velimezi, Lydia Robinson-Garcia, Francisco Muñoz-Martínez, Wouter W Wiegant, Joana Ferreira da Silva, Michel Owusu, Martin Moder, Marc Wiedner, Sara Brin Rosenthal, Kathleen M Fisch, Jason Moffat, Jörg Menche, Haico van Attikum, Stephen P Jackson, Joanna I Loizou
Defects in DNA repair can cause various genetic diseases with severe pathological phenotypes. Fanconi anemia (FA) is a rare disease characterized by bone marrow failure, developmental abnormalities, and increased cancer risk that is caused by defective repair of DNA interstrand crosslinks (ICLs). Here, we identify the deubiquitylating enzyme USP48 as synthetic viable for FA-gene deficiencies by performing genome-wide loss-of-function screens across a panel of human haploid isogenic FA-defective cells (FANCA, FANCC, FANCG, FANCI, FANCD2)...
June 11, 2018: Nature Communications
https://www.readbyqxmd.com/read/29884039/force-induced-rupture-of-double-stranded-dna-in-the-absence-and-presence-of-covalently-bonded-anti-tumor-drugs-insights-from-molecular-dynamics-simulations
#6
Anurag Upadhyaya, Shesh Nath, Sanjay Kumar
DNA intra-strand cross-link (ICL) agents are widely used in the treatment of cancer. ICLs are thought to form a link between the same strand (intra-strand) or complimentary strand (inter-strand) and thereby increase the stability of DNA, which forbids the processes like replication and transcription. As a result, cell death occurs. In this work, we have studied the enhanced stability of a double stranded DNA in the presence of ICLs and compared our findings with the results obtained in the absence of these links...
June 7, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29849128/co-inhibition-of-pol-%C3%AE-and-atr-sensitizes-cisplatin-resistant-non-small-cell-lung-cancer-cells-to-cisplatin-by-impeding-dna-damage-repair
#7
Xiao-Qin Li, Jin Ren, Ping Chen, Yu-Jiao Chen, Min Wu, Yan Wu, Kang Chen, Jian Li
For the majority of patients with advanced non-small cell lung cancer (NSCLC), the standard of care remains platinum-based chemotherapy. However, cisplatin resistance is a big obstacle to the treatment, and elucidation of its mechanism is warranted. In this study, we showed that there was no difference in intracellular uptake of cisplatin or the removal of platinum-DNA adducts between a cisplatin-resistant NSCLC cell line (A549/DR) and a cisplatin-sensitive NSCLC cell line (A549). However, the capacity to repair DNA interstrand crosslinks (ICLs) and double-strand breaks (DSBs) was significantly enhanced in the A549/DR cell line compared to 3 cisplatin-sensitive cell lines...
May 31, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29795289/distinct-roles-of-xpf-ercc1-and-rad1-rad10-saw1-in-replication-coupled-and-uncoupled-inter-strand-crosslink-repair
#8
Ja-Hwan Seol, Cory Holland, Xiaolei Li, Christopher Kim, Fuyang Li, Melisa Medina-Rivera, Robin Eichmiller, Ignacio F Gallardo, Ilya J Finkelstein, Paul Hasty, Eun Yong Shim, Jennifer A Surtees, Sang Eun Lee
Yeast Rad1-Rad10 (XPF-ERCC1 in mammals) incises UV, oxidation, and cross-linking agent-induced DNA lesions, and contributes to multiple DNA repair pathways. To determine how Rad1-Rad10 catalyzes inter-strand crosslink repair (ICLR), we examined sensitivity to ICLs from yeast deleted for SAW1 and SLX4, which encode proteins that interact physically with Rad1-Rad10 and bind stalled replication forks. Saw1, Slx1, and Slx4 are critical for replication-coupled ICLR in mus81 deficient cells. Two rad1 mutations that disrupt interactions between Rpa1 and Rad1-Rad10 selectively disable non-nucleotide excision repair (NER) function, but retain UV lesion repair...
May 23, 2018: Nature Communications
https://www.readbyqxmd.com/read/29794164/the-aspergillus-nidulans-pyruvate-dehydrogenase-kinases-are-essential-to-integrate-carbon-source-metabolism
#9
Laure Nicolas Annick Ries, Leandro José de Assis, Fernando José Santos Rodrigues, Camila Caldana, Marina Campos Rocha, Iran Malavazi, Özgür Bayram, Gustavo H Goldman
The pyruvate dehydrogenase complex (PDH), that converts pyruvate to acetyl-coA, is regulated by pyruvate dehydrogenase kinases (PDHK) and phosphatases (PDHP) that have been shown to be important for morphology, pathogenicity and carbon source utilisation in different fungal species. The aim of this study was to investigate the role played by the three PDHKs PkpA, PkpB and PkpC in carbon source utilisation in the reference filamentous fungus Aspergillus nidulans , in order to unravel regulatory mechanisms which could prove useful for fungal biotechnological and biomedical applications...
May 24, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29788478/a-minimal-threshold-of-fancj-helicase-activity-is-required-for-its-response-to-replication-stress-or-double-strand-break-repair
#10
Sanjay Kumar Bharti, Joshua A Sommers, Sanket Awate, Marina A Bellani, Irfan Khan, Lynda Bradley, Graeme A King, Yeonee Seol, Venkatasubramanian Vidhyasagar, Yuliang Wu, Takuye Abe, Koji Kobayashi, Kazuo Shin-Ya, Hiroyuki Kitao, Marc S Wold, Dana Branzei, Keir C Neuman, Robert M Brosh
Fanconi Anemia (FA) is characterized by bone marrow failure, congenital abnormalities, and cancer. Of over 20 FA-linked genes, FANCJ uniquely encodes a DNA helicase and mutations are also associated with breast and ovarian cancer. fancj-/- cells are sensitive to DNA interstrand cross-linking (ICL) and replication fork stalling drugs. We delineated the molecular defects of two FA patient-derived FANCJ helicase domain mutations. FANCJ-R707C was compromised in dimerization and helicase processivity, whereas DNA unwinding by FANCJ-H396D was barely detectable...
May 21, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29782146/multiscale-interfacial-strategy-to-engineer-mixed-metal-oxide-anodes-towards-an-enhanced-cycling-efficiency
#11
Yue Ma, Cheuk-Wai Tai, Shaowen Li, Kristina Edstrom, Bingqing Wei
Interconnected macro/mesoporous structures of mixed metal oxide (MMO) are developed on nickel foam as free-standing anodes for Li-ion batteries. The sustainable production is realized via a wet chemical etching process with bio-friendly chemicals. By means of the divalent iron doping during an in-situ re-crystallization process, the as-developed MMO anodes exhibit the enhanced levels of cycling efficiency. Furthermore, this atomic-scale modification coherently synergies with the encapsulation layer across a micrometer scale...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29780917/advanced-pigment-dispersion-glaucoma-secondary-to-phakic-intraocular-collamer-lens-implant
#12
Clara Ye, Cajal K Patel, Anna C Momont, Yao Liu
Purpose: We report a case of pigment dispersion glaucoma secondary to uncomplicated phakic intraocular collamer lens (ICL) (Visian ICL™, Staar Inc., Monrovia, CA) implant that resulted in advanced visual field loss. Observations: A 50-year-old man presented for routine follow-up status post bilateral phakic intraocular collamer lens (ICL) placement 8 years earlier. He was incidentally found to have a decline in visual acuity from an anterior subcapsular cataract and elevated intraocular pressure (IOP) in the left eye...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29752642/can-short-term-pasture-management-increase-c-balance-in-the-atlantic-rainforest
#13
Paulo Roberto da Rocha Junior, Felipe Vaz Andrade, Lucas Santos Satiro, Guilherme Kangussú Donagemma, Eduardo de Sá Mendonça
Few studies have shown the importance of different pasture management practices on C storage and the reduction of CO2 -C emissions in tropical conditions. The objective of the present study was to determine short-term changes in C pools and C balance from different pasture management practices established in the Atlantic Rainforest. A field study was carried out in Alegre, ES, Brazil from September 2013 to August 2014 to investigate the first-year effect of pasture management practices on a Udult clayey soil...
May 11, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29743110/analysis-of-intraocular-positions-of-posterior-implantable-collamer-lens-by-full-scale-ultrasound-biomicroscopy
#14
Xi Zhang, Xun Chen, Xiaoying Wang, Fei Yuan, Xingtao Zhou
BACKGROUND: To analyze the positions of intraocular posterior Implantable Collamer Lens (ICL) and its possible relationship with vault. METHODS: This cross-sectional study included 72 patients with high myopia (134 eyes) who were followed up after phakic intraocular lens implantation. The postoperative time ranged from 1 week to 7 years. We obtained the images of ICL by using Compact Touch STS UBM and observed the position of ICL in posterior chamber and ciliary sulcus...
May 9, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29708928/revisiting-monovision-for-presbyopia
#15
Abdallah Mahrous, Jessica B Ciralsky, Edward C Lai
PURPOSE OF REVIEW: Presbyopia is an inevitable age-related loss of accommodation that results in spectacle dependence with common everyday near-vision tasks. Many surgical approaches to presbyopic correction have been investigated, with monovision correction being amongst the most common and attractive options. In this article, we will review the advantages and disadvantages of the new modalities of presbyopic monovision correction. RECENT FINDINGS: New methods such as mini-monovision, corneal inlays, and multifocal corneal ablation aim to maximize stereopsis and decrease the anisometropic side effects of conventional monovision...
July 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29679802/the-evolving-role-of-dna-inter-strand-crosslinks-in-chemotherapy
#16
REVIEW
Halley B Rycenga, David T Long
DNA crosslinking agents make up a broad class of chemotherapy agents that target rapidly dividing cancer cells by disrupting DNA synthesis. These drugs differ widely in both chemical structure and biological effect. In cells, crosslinking agents can form multiple types of DNA lesions with varying efficiencies. Inter-strand crosslinks (ICLs) are considered to be the most cytotoxic lesion, creating a covalent roadblock to replication and transcription. Despite over 50 years in the clinic, the use of crosslinking agents that specialize in the formation of ICLs remains limited, largely due to high toxicity in patients...
April 18, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29677222/understanding-the-impact-of-the-cofactor-swapping-of-isocitrate-dehydrogenase-over-the-growth-phenotype-of-escherichia-coli-on-acetate-by-using-constraint-based-modeling
#17
Erick Armingol, Eduardo Tobar, Ricardo Cabrera
It has been proposed that NADP+-specificity of isocitrate dehydrogenase (ICDH) evolved as an adaptation of microorganisms to grow on acetate as the sole source of carbon and energy. In Escherichia coli, changing the cofactor specificity of ICDH from NADP+ to NAD+ (cofactor swapping) decreases the growth rate on acetate. However, the metabolic basis of this phenotype has not been analyzed. In this work, we used constraint-based modeling to investigate the effect of the cofactor swapping of ICDH in terms of energy production, response of alternative sources of NADPH, and partitioning of fluxes between ICDH and isocitrate lyase (ICL) -a crucial bifurcation when the bacterium grows on acetate-...
2018: PloS One
https://www.readbyqxmd.com/read/29675387/comparison-of-optical-quality-after-implantable-collamer-lens-implantation-and-wavefront-guided-laser-in-situ-keratomileusis
#18
Hong-Ting Liu, Zhou Zhou, Wu-Qiang Luo, Wen-Jing He, Owhofasa Agbedia, Jiang-Xia Wang, Jian-Zhong Huang, Xin Gao, Min Kong, Min Li, Li Li
AIM: To compare the optical quality after implantation of implantable collamer lens (ICL) and wavefront-guided laser in situ keratomileusis (WG-LASIK). METHODS: The study included 40 eyes of 22 patients with myopia who accepted ICL implantation and 40 eyes of 20 patients with myopia who received WG-LASIK. Before surgery and three months after surgery, the objective scattering index (OSI), the values of modulation transfer function (MTF) cutoff frequency, Strehl ratio, and the Optical Quality Analysis System (OQAS) values (OVs) were accessed...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29644243/comparison-of-visual-refractive-and-aberration-measurements-of-intacs-versus-toric-icl-lens-implantation-a-four-year-follow-up
#19
Shahrokh Ramin, Azad Sangin Abadi, Farideh Doroodgar, Mehrdad Esmaeili, Faizollah Niazi, Sana Niazi, Cyrus Alinia, Yaser Golestani, Reza Taj Abadi
This study was performed to evaluate the visual, refractive, and aberration measurement results of 2 implants, including Intacs Intracorneal Ring Segments (ICRS) and phakic Toric Implantable Collamer Lens (TICL), in patients with moderate Keratoconus (KCN). In this retrospective cross-sectional study, 30 patients with KCN with a mean age of 29.83 years were included in 2 groups, including the Intacs Intracorneal Ring Segments (ICRS) group and the phakic Toric Implantable Collamer Lens (TICL) group. Preoperative data as well as 6-month, 1-, 2-, 3- and 4-year follow-up data after the operation were collected and analyzed with the SPSS software (ver...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
https://www.readbyqxmd.com/read/29607278/molecular-dynamics-simulation-study-on-the-structural-instability-of-the-most-common-cystic-fibrosis-associated-mutant-%C3%AE-f508-cftr
#20
Mitsuhiko Odera, Tadaomi Furuta, Yoshiro Sohma, Minoru Sakurai
Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel that belongs to the ATP binding cassette protein superfamily. Deletion of phenylalanine at position 508 (ΔF508) is the most common CF-associated mutation and is present in nearly 90% of CF patients. Currently, atomistic level studies are insufficient for understanding the mechanism by which the deletion of a single amino acid causes greatly reduced folding as well as trafficking and gating defects. To clarify this mechanism, we first constructed an atomic model of the inward-facing ΔF508-CFTR and performed allatom molecular dynamics (MD) simulations of the protein in a membrane environment...
2018: Biophysics and Physicobiology
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