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https://www.readbyqxmd.com/read/27931306/idiopathic-cd4-lymphocytopenia
#1
Joel P Brooks, Gisoo Ghaffari
BACKGROUND: Idiopathic CD4 lymphocytopenia (ICL) is a rare disorder of unknown etiology. Diagnostic criteria include a persistent CD4 T-cell lymphopenia with no underlying primary or secondary immune deficiencies and a CD4 T-cell count of 300 cells/mL or 20% total lymphocyte on multiple occasions. OBJECTIVE: To increase awareness of ICL and to provide a review of the clinical characteristics, diagnosis, and management of this disease process. Presently, many of these patients receive prophylactic treatment similar to other T-cell deficient conditions, most notably patients with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome; however, the same indications may not necessarily apply to this patient population because the T cells are not affected by a virus as in HIV...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27930796/surgical-correction-of-presbyopic-ametropia-with-non-refractive-transparent-corneal-inlay-and-an-implantable-collamer-lens
#2
Carlos Gutierrez Amoros
PURPOSE: To report the clinical outcomes of two patients implanted with the Raindrop Near Vision Inlay (ReVision Optics, Inc., Lake Forest, CA) to correct for presbyopia and the Visian implantable collamer lens (ICL) (STAAR Surgical, Monrovia, CA) to correct refractive error. METHODS: Case report. RESULTS: Two patients with presbyopic ametropia complained of blurred vision for distance and near. Both patients received a corneal inlay in the non-dominant eye followed by the Raindrop Inlay the following day...
December 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27911399/tools-to-study-the-role-of-architectural-protein-hmgb1-in-the-processing-of-helix-distorting-site-specific-dna-interstrand-crosslinks
#3
Anirban Mukherjee, Karen M Vasquez
High mobility group box 1 (HMGB1) protein is a non-histone architectural protein that is involved in regulating many important functions in the genome, such as transcription, DNA replication, and DNA repair. HMGB1 binds to structurally distorted DNA with higher affinity than to canonical B-DNA. For example, we found that HMGB1 binds to DNA interstrand crosslinks (ICLs), which covalently link the two strands of the DNA, cause distortion of the helix, and if left unrepaired can cause cell death. Due to their cytotoxic potential, several ICL-inducing agents are currently used as chemotherapeutic agents in the clinic...
November 10, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27900095/intravenous-leiomyomatosis-with-right-atrium-extension-in-two-patients-a-case-report
#4
Lianxue Zhang, Yang Duan, Fulin Song, Junrui Xiao, Benqiang Yang
Intravenous leiomyomatosis (IVL) is a rare benign tumor of the uterus mesoderm, which can spread via the vein, from the micro-vein to the inferior vena cava, and even to the right atrium. IVL was first described this disease in 1896 and the first presented case of IVL with right atrium extension in the autopsy was described in 1907. On rare occasions, the tumors may extend into the regional and systemic veins, thus reaching the heart. This may subsequently cause intracardiac leiomyomatosis (ICL), which may lead to congestive heart failure and on occasion, sudden fatalities...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27898450/update-on-treating-high-myopia-with-implantable-collamer-lenses
#5
Xiaoying Wang, Xingtao Zhou
The purpose of this article is to provide updates on the treatment of high myopia with the implantable collamer lens (ICL). The ICL has become an important technique used in intraocular refractive surgery. With improvements in material, design, and application, the ICL has good efficacy, predictability, long-term safety and stability, manageable complications, and reversibility. More and more refractive surgeons are taking note of the ICL. This article reviews the material characteristics and the latest designs of the ICL along with the clinical applications, visual quality, and future development...
November 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27881850/relationship-between-asymptomatic-intra-cranial-lesions-and-brachial-ankle-pulse-wave-velocity-in-coronary-artery-disease-patients-without-stroke
#6
Noriaki Tabata, Daisuke Sueta, Takayoshi Yamashita, Daisuke Utsunomiya, Yuichiro Arima, Eiichiro Yamamoto, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Seiji Hokimoto
Little is known about the significance of asymptomatic intra-cranial lesions (ICL) identified by brain MRI in coronary artery disease (CAD) patients. Silent cerebral lesions are suggested to be associated with arterial stiffness in healthy subjects. We investigated whether subclinical ICL are associated with arterial stiffness and the prognosis in CAD patients without medical history of cerebrovascular diseases. We recruited CAD patients who required percutaneous coronary intervention (PCI), did not meet exclusion criteria, and agreed with MRI before PCI...
November 24, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27870471/analytical-evaluation-of-the-adams-%C3%A2-a1c-ha-8180-thalassemia-mode-high-pressure-liquid-chromatography-analyser-for-the-measurement-of-hba2-and-hbf
#7
E Urrechaga
BACKGROUND: ADAMS(™) A1cHA-8180T is a HPLC system; within 3.5 min, it quantifies HbF, HbA2 , and HbA0 and flags abnormal peaks. We evaluate its analytical performance for routine estimation of HbA2 and HbF, and critical tests were performed for identifying β-thalassemia carriers. METHODS: Trueness imprecision, carry over, linearity, and effect of anemia were evaluated according to ICLH, ICLS, or manufacture's guidelines. Comparison (ADAMS(™) A1c HA-8160T) was performed by running 400 samples from healthy subjects, 30 alpha and 80 beta carriers (range: 1...
December 2016: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/27862755/dna-interstrand-crosslinks-by-h-pin-polyamide-s-seco-cbi-conjugates
#8
Chuanxin Guo, Sefan Asamitsu, Gengo Kashiwazaki, Shinsuke Sato, Toshikazu Bando, Hiroshi Sugiyama
Although DNA interstrand crosslinking (ICL) agents are widely used as antitumor drugs, DNA sequence-specific ICL agents are quite rare. In this study, H-pin imidazole-pyrrole polyamide 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indol-5-ol (seco-CBI) conjugates that produce sequence-specific DNA ICLs were designed and synthesized. Conjugates with H-pin polyamide and seco-CBI moieties were constructed to recognize a 7 bp DNA sequence, and their reactivity and selectivity in DNA alkylation were evaluated by using high-resolution denaturing gel electrophoresis and sequence-specific plasmid cleavage...
November 15, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27859335/extracellular-protons-enable-activation-of-the-calcium-dependent-chloride-channel-tmem16a-ano1
#9
Silvia Cruz-Rangel, José J De Jesus-Pérez, Iván A Aréchiga-Figueroa, Aldo A Rodríguez-Menchaca, Patricia Pérez-Cornejo, H Criss Hartzell, Jorge Arreola
TMEM16A (ANO1), the pore forming subunit of a Ca(2+) -dependent Cl(-) channel (CaCC), is activated by direct, voltage-dependent, binding of intracellular Ca(2+) . Endogenous CaCCs are regulated by extracellular protons; however, the molecular basis of such regulation remains unidentified. Here, we evaluated the effects of different extracellular proton concentrations ([H(+) ]o ) on mouse TMEM16A expressed in HEK-293 cells using whole-cell and inside-out patch clamp recordings. We found that increasing the [H(+) ]o from 10(-10) to 10(-5...
November 17, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27855172/etiology-and-management-of-raised-intraocular-pressure-following-posterior-chamber-phakic-intraocular-lens-implantation-in-myopic-eyes
#10
Sirisha Senthil, Nikhil S Choudhari, Pravin K Vaddavalli, Somasheila Murthy, Jagadesh Reddy, Chandra S Garudadri
AIM: To evaluate the etiology and management of elevated intraocular pressure (IOP) following posterior chamber phakic implantable collamer lens (ICL) surgery. METHODS: Between 2009 and 2015, 638 eyes of 359 subjects with refractive myopia, underwent V4b and V4c (CentraFLOW) model ICL implantation. Ocular hypertension (OHT) was defined as IOP of ≥ 22 mm Hg on two separate occasions and elevated IOP with corresponding optic disc or visual field damage was defined as glaucoma...
2016: PloS One
https://www.readbyqxmd.com/read/27852246/comparison-of-intraocular-pressure-andvault-after-implantation-of-implantable-collamer-lens-with-and-without-a-central-hole
#11
Haiting Chen, Guangzeng Niu, Yuxiang Fan, Jingxue Ma
BACKGROUD: The Implantable Collamer Lens (ICL) has been used widely for refractive errors, We performed this prospective randomized comparative study to compare postoperative intraocular pressure (IOP) and vaults of the eyes implanted with conventional ICL and central hole ICL. METHODS: This study evaluated 44 eyes of 22 patients who underwent central hole ICL implantation in one eye and conventional ICL implantation in the other eye by randomization assignment...
November 16, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27852100/withdrawn-acupuncture-for-neck-disorders
#12
REVIEW
Kien Trinh, Nadine Graham, Dominik Irnich, Ian D Cameron, Mario Forget
BACKGROUND: Neck pain is one of the three most frequently reported complaints of the musculoskeletal system. Treatments for neck pain are varied, as are perceptions of benefit. Acupuncture has been used as an alternative to more conventional treatment for musculoskeletal pain. This review summarises the most current scientific evidence on the effectiveness of acupuncture for acute, subacute and chronic neck pain. This update replaces our 2006 Cochrane review update on this topic. OBJECTIVES: To determine the effects of acupuncture for adults with neck pain, with focus on pain relief, disability or functional measures, patient satisfaction and global perceived effect...
November 17, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27846863/prognostic-significance-of-mucin-expression-profiles-in-breast-carcinoma-with-signet-ring-cells-a-clinicopathological-study
#13
Ryuji Ohashi, Ayako Hayama, Keiko Yanagihara, Koji Yamashita, Takashi Sakatani, Hiroyuki Takei, Zenya Naito
BACKGROUND: Signet ring cells (SRCs) often accompany gastrointestinal carcinoma, referred to as SRC carcinoma; however, breast cancers containing SRCs have not been well characterized, leaving the prognostic significance of SRCs undetermined. We have described clinicopathological characteristics of patients with breast cancer containing SRCs in relation to the expression levels of MUC1, MUC2, MUC4, MUC5AC, and MUC6. METHODS: Twenty-two breast cancer cases with variable degrees of SRC population were retrospectively studied...
November 15, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27834954/strong-antitumor-synergy-between-dna-crosslinking-and-hsp90-inhibition-causes-massive-premitotic-dna-fragmentation-in-ovarian-cancer-cells
#14
Daniela Kramer, Nadine Stark, Ramona Schulz-Heddergott, Norman Erytch, Shelley Edmunds, Laura Roßmann, Holger Bastians, Nicole Concin, Ute M Moll, Matthias Dobbelstein
All current regimens for treating ovarian cancer center around carboplatin as standard first line. The HSP90 inhibitor ganetespib is currently being assessed in advanced clinical oncology trials. Thus, we tested the combined effects of ganetespib and carboplatin on a panel of 15 human ovarian cancer lines. Strikingly, the two drugs strongly synergized in cytotoxicity in tumor cells lacking wild-type p53. Mechanistically, ganetespib and carboplatin in combination, but not individually, induced persistent DNA damage causing massive global chromosome fragmentation...
November 11, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27830887/anatomical-transverse-mri-study-of-ligaments-in-palmar-surface-of-metacarpus-miniature-donkey-introduce-a-new-ligament
#15
Mohammad Naser Nazem, Sayed Mohsen Sajjadian
BACKGROUND: Palmar region of metacarpus in the horses and donkeys is an important region because of its tendons and ligaments which contribute to stay apparatus. This study was done on forelimbs of six healthy Miniature donkeys to detect the tendons, ligaments and their accessories on the palmar surface of metacarpus in this animal. MATERIALS AND METHODS: Based on that MRI is a good technique to evaluate the soft tissues such as tendons and ligaments, palmar aspects of metacarpus in 6 euthanatized Miniature donkeys were prepared for anatomical and trans sectional MRI studies to determine the tendons and ligaments in this region...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27819275/the-pten-phosphatase-functions-cooperatively-with-the-fanconi-anemia-proteins-in-dna-crosslink-repair
#16
Elizabeth A Vuono, Ananda Mukherjee, David A Vierra, Morganne M Adroved, Charlotte Hodson, Andrew J Deans, Niall G Howlett
Fanconi anemia (FA) is a genetic disease characterized by bone marrow failure and increased cancer risk. The FA proteins function primarily in DNA interstrand crosslink (ICL) repair. Here, we have examined the role of the PTEN phosphatase in this process. We have established that PTEN-deficient cells, like FA cells, exhibit increased cytotoxicity, chromosome structural aberrations, and error-prone mutagenic DNA repair following exposure to ICL-inducing agents. The increased ICL sensitivity of PTEN-deficient cells is caused, in part, by elevated PLK1 kinase-mediated phosphorylation of FANCM, constitutive FANCM polyubiquitination and degradation, and the consequent inefficient assembly of the FA core complex, FANCD2, and FANCI into DNA repair foci...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27803858/implantable-collamer-lens-for-residual-refractive-error-after-corneal-refractive-surgery
#17
Xun Chen, Xiao-Ying Wang, Xi Zhang, Zhi Chen, Xing-Tao Zhou
AIM: To assess the safety, efficacy, predictability and stability of implantable collamer lens (ICL) for residual refractive error after corneal refractive surgery. METHODS: This study evaluated 19 eyes of 12 patients who underwent ICL implantation after corneal refractive surgeries. They were followed up for 1y to 5y of uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refractive error, flat and steep K value, axial length, intraocular pressure, corneal endothelial cell density, adverse events after ICL surgery...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27800579/performance-of-growth-mixture-models-in-the-presence-of-time-varying-covariates
#18
Thierno M O Diallo, Alexandre J S Morin, HuiZhong Lu
Growth mixture modeling is often used to identify unobserved heterogeneity in populations. Despite the usefulness of growth mixture modeling in practice, little is known about the performance of this data analysis technique in the presence of time-varying covariates. In the present simulation study, we examined the impacts of five design factors: the proportion of the total variance of the outcome explained by the time-varying covariates, the number of time points, the error structure, the sample size, and the mixing ratio...
October 31, 2016: Behavior Research Methods
https://www.readbyqxmd.com/read/27799301/anoctamin-6-contributes-to-cl-secretion-in-accessory-cholera-enterotoxin-ace-stimulated-diarrhea-an-essential-role-for-pip2-signaling-in-cholera
#19
Joydeep Aoun, Mikio Hayashi, Irshad Ali Sheikh, Paramita Sarkar, Tultul Saha, Priyanka Ghosh, Rajsekhar Bhowmick, Dipanjan Ghosh, Tanaya Chatterjee, Pinak Chakrabarti, Manoj K Chakrabarti, Kazi Mirajul Hoque
Accessory cholera enterotoxin (Ace) of Vibrio cholerae has been shown to contribute to diarrhea However, the signaling mechanism and specific type of Cl- channel activated by Ace is yet unknown. We have shown here that the recombinant Ace protein induced ICl of apical plasma membrane which were inhibited by classical CaCC blockers. Surprisingly, Ace elicited rise of current was neither affected by Ano1 (Tmem16a) specific inhibitor T16A(inh)-AO1(TAO1) nor by CFTR blocker, CFTR inh-172. Ace stimulated whole-cell current in Caco-2 cells...
October 31, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27774531/depth-profiles-of-hydrogen-bound-water-molecule-types-and-their-relation-to-lipid-and-protein-interaction-in-the-human-stratum-corneum-in-vivo
#20
ChunSik Choe, Jürgen Lademann, Maxim E Darvin
Confocal Raman microscopy has been used to measure depth-dependent profiles of human SC in vivo in the high wavenumber (HWN) region. In order to keep the linearity of HWN region boundaries and to not remove an informative signal from Raman spectra, a new baseline subtraction procedure has been introduced. After baseline subtraction, the HWN spectrum was deconvoluted using 10 Gaussian functions with individual chemical meanings. The results show that the hydrogen bound water molecule types contributed differently to the water diffusion process in the SC...
October 24, 2016: Analyst
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