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https://www.readbyqxmd.com/read/28729370/anterior-segment-optical-coherence-tomography-angle-and-vault-analysis-after-toric-and-non-toric-implantable-collamer-lens-v4c-implantation-in-patients-with-high-myopia
#1
Guillermo Garcia-De la Rosa, Andrew Olivo-Payne, Juan Carlos Serna-Ojeda, Maria Sandra Salazar-Ramos, Alejandro Lichtinger, Arturo Gomez-Bastar, Arturo Ramirez-Miranda, Alejandro Navas, Enrique O Graue-Hernandez
OBJECTIVE: To assess anterior segment changes, including iridocorneal angle and vault, after toric and non-toric implantable collamer lens (ICL) V4c (STAAR Surgical AG) implantation under different lighting conditions. METHODS: Longitudinal, prospective, case series. Patients with high myopia (>6 dioptres) underwent toric and non-toric ICL V4c implantation. Optical coherence tomography measurements were taken under different lighting conditions preoperatively and at 1 week and 1, 6 and 12 months of follow-up...
July 20, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28694253/implementing-the-compassion-intervention-a-model-for-integrated-care-for-people-with-advanced-dementia-towards-the-end-of-life-in-nursing-homes-a-naturalistic-feasibility-study
#2
Kirsten J Moore, Bridget Candy, Sarah Davis, Anna Gola, Jane Harrington, Nuriye Kupeli, Victoria Vickerstaff, Michael King, Gerard Leavey, Irwin Nazareth, Rumana Z Omar, Louise Jones, Elizabeth L Sampson
BACKGROUND: Many people with dementia die in nursing homes, but quality of care may be suboptimal. We developed the theory-driven 'Compassion Intervention' to enhance end-of-life care in advanced dementia. OBJECTIVES: To (1) understand how the Intervention operated in nursing homes in different health economies; (2) collect preliminary outcome data and costs of an interdisciplinary care leader (ICL) to facilitate the Intervention; (3) check the Intervention caused no harm...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28687272/interstrand-crosslink-repair-as-a-target-for-hdac-inhibition
#3
REVIEW
Teodora Nikolova, Nicole Kiweler, Oliver H Krämer
DNA interstrand crosslinks (ICLs) covalently connect complementary DNA strands. Consequently, DNA replication and transcription are hampered, DNA damage responses (DDR) are initiated, and cell death is triggered. Therefore, drugs inducing ICLs are effective against rapidly growing cancer cells. However, tumors engage a complicated enzymatic machinery to repair and survive ICLs. Several factors, including the post-translational acetylation/deacetylation of lysine residues within proteins, control this network...
July 4, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28684355/studies-of-protein-protein-interactions-in-fanconi-anemia-pathway-to-unravel-the-dna-interstrand-crosslink-repair-mechanism
#4
Mohd Quadir Siddiqui, Yogendra S Rajpurohit, Pankaj S Thapa, Ganesh Kumar Maurya, Kuheli Banerjee, Mudassar Ali Khan, Pragnya Panda, Syed K Hasan, Nikhil Gadewal, Hari S Misra, Ashok K Varma
Fanconi anemia (FA), a cancer predisposition syndrome exhibits hallmark feature of radial chromosome formation, and hypersensitivity to DNA crosslinking agents. A set of FA pathway proteins mainly FANCI, FANCD2 and BRCA2 are expressed to repair the covalent crosslink between the dsDNA. However, FA, BRCA pathways play an important role in DNA ICL repair as well as in homologous recombination repair, but the presumptive role of FA-BRCA proteins has not clearly explored particularly in context to function associated protein-protein interactions (PPIs)...
July 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28679637/mechanism-based-inactivator-of-isocitrate-lyases-1-and-2-from-mycobacterium-tuberculosis
#5
Truc V Pham, Andrew S Murkin, Margaret M Moynihan, Lawrence Harris, Peter C Tyler, Nishant Shetty, James C Sacchettini, Hsiao-Ling Huang, Thomas D Meek
Isocitrate lyase (ICL, types 1 and 2) is the first enzyme of the glyoxylate shunt, an essential pathway for Mycobacterium tuberculosis (Mtb) during the persistent phase of human TB infection. Here, we report 2-vinyl-d-isocitrate (2-VIC) as a mechanism-based inactivator of Mtb ICL1 and ICL2. The enzyme-catalyzed retro-aldol cleavage of 2-VIC unmasks a Michael substrate, 2-vinylglyoxylate, which then forms a slowly reversible, covalent adduct with the thiolate form of active-site Cys191 2-VIC displayed kinetic properties consistent with covalent, mechanism-based inactivation of ICL1 and ICL2 with high efficiency (partition ratio, <1)...
July 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28668303/ca-2-activated-cl-current-is-antiarrhythmic-by-reducing-both-spatial-and-temporal-heterogeneity-of-cardiac-repolarization
#6
Bence Hegyi, Balázs Horváth, Krisztina Váczi, Mónika Gönczi, Kornél Kistamás, Ferenc Ruzsnavszky, Roland Veress, Leighton T Izu, Ye Chen-Izu, Tamás Bányász, János Magyar, László Csernoch, Péter P Nánási, Norbert Szentandrássy
The role of Ca(2+)-activated Cl(-) current (ICl(Ca)) in cardiac arrhythmias is still controversial. It can generate delayed afterdepolarizations in Ca(2+)-overloaded cells while in other studies incidence of early afterdepolarization (EAD) was reduced by ICl(Ca). Therefore our goal was to examine the role of ICl(Ca) in spatial and temporal heterogeneity of cardiac repolarization and EAD formation. Experiments were performed on isolated canine cardiomyocytes originating from various regions of the left ventricle; subepicardial, midmyocardial and subendocardial cells, as well as apical and basal cells of the midmyocardium...
June 29, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28662940/impacts-of-implantable-collamer-lens-v4c-placement-on-angle-measurements-made-by-optical-coherence-tomography-two-year-follow-up
#7
José Ignacio Fernández-Vigo, Ana Macarro-Merino, Cristina Fernández-Vigo, José Ángel Fernández-Vigo, Lucía De-Pablo-Gómez-de-Liaño, Cristina Fernández-Pérez, Julián García-Feijóo
PURPOSE: To determine iridocorneal angle changes produced after two years of implantable collamer lens(®) (ICL) V4c (STAAR Surgical AG) placement by Fourier-domain optical coherence tomography (FD-OCT). DESIGN: Prospective interventional case series. METHODS: In 54 eyes of 27 myopic subjects FD-OCT (RTVue(®), Optovue Inc.) iridocorneal angle measurements were made before, and 1 month, 3 months, 1 year and 2 years after ICL implant. Trabecular-iris angle (TIA), angle opening distance 500 μm from the scleral spur (AOD500) and iridotrabecular contact length (TICL) were compared among these time points and the quadrants nasal, temporal and inferior...
June 26, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28654754/potential-strategies-to-target-protein-protein-interactions-in-the-dna-damage-response-and-repair-pathways
#8
Naoaki Fujii
This review article discusses some insights about generating novel mechanistic inhibitors of the DNA damage response and repair (DDR) pathways by focusing on protein-protein interactions (PPIs) of the key DDR components. General requirements for PPI strategies, such as selecting the target PPI site on the basis of its functionality, are discussed first. Next, on the basis of functional rationale and biochemical feasibility to identify a PPI inhibitor, 26 PPIs in DDR pathways (BER, MMR, NER, NHEJ, HR, TLS, and ICL repair) are specifically discussed for inhibitor discovery to benefit cancer therapies using a DNA-damaging agent...
July 12, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28652643/hybrid-tandem-quantum-dot-organic-photovoltaic-cells-with-complementary-near-infrared-absorption
#9
Taesoo Kim, Elenita Palmiano, Ru-Ze Liang, Hanlin Hu, Banavoth Murali, Ahmad R Kirmani, Yuliar Firdaus, Yangqin Gao, Arif Sheikh, Mingjian Yuan, Omar F Mohammed, Sjoerd Hoogland, Pierre M Beaujuge, Edward H Sargent, Aram Amassian
Monolithically integrated hybrid tandem solar cells that effectively combine solution-processed colloidal quantum dot (CQD) and organic bulk heterojunction subcells to achieve tandem performance that surpasses the individual subcell efficiencies have not been demonstrated to date. In this work, we demonstrate hybrid tandem cells with a low bandgap PbS CQD subcell harvesting the visible and near-infrared photons and a polymer:fullerene-poly (diketopyrrolopyrrole-terthiophene) (PDPP3T):[6,6]-phenyl-C60-butyric acid methyl ester (PC61BM)-top cell absorbing effectively the red and near-infrared photons of the solar spectrum in a complementary fashion...
May 29, 2017: Applied Physics Letters
https://www.readbyqxmd.com/read/28650856/a-rare-case-of-pupillary-block-glaucoma-following-centraflow-implantable-collamer-lens-surgery
#10
Isha G Grover, Sirisha Senthil, Somasheila Murthy, Jagadesh C Reddy
A 28-year-old lady with a refractive error of -11.0 D sphere/-1.50 D cylinder at 160 degrees in the right eye underwent an uneventful Implantable Collamer Lens surgery (ICL) with a V4c model, which uses a central Aquaport. This ICL does not require preoperative laser iridotomy or surgical iridectomy, as the centraflow opening is designed to prevent pupillary block. At postoperative day 1, her visual acuity in the right eye was 20/400, with diffuse microcystic corneal edema with fixed, dilated pupil and high intraocular pressure...
June 23, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28645378/preparation-of-stable-nitrogen-mustard-dna-interstrand-cross-link-analogs-for-biochemical-and-cell-biological-studies
#11
Alejandra Castaño, Upasana Roy, Orlando D Schärer
Nitrogen mustards (NMs) react with two bases on opposite strands of a DNA duplex to form a covalent linkage, yielding adducts called DNA interstrand cross-links (ICLs). This prevents helix unwinding, blocking essential processes such as replication and transcription. Accumulation of ICLs causes cell death in rapidly dividing cells, especially cancer cells, making ICL-forming agents like NMs valuable in chemotherapy. However, the repair of ICLs can contribute to chemoresistance through a number of pathways that remain poorly understood...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28640145/comparison-of-implantable-collamer-lens-visian-icl-v4-and-icl-v4c-for-high-myopia-a-cohort-study
#12
COMPARATIVE STUDY
Ying Tian, Hai-Bo Jiang, Jian Jiang, Dan Wen, Xiao-Bo Xia, Wei-Tao Song
The aim of this study was to investigate the visual quality of the 2 kinds of intraocular lens: Visian implantable collamer lens (ICL) V4 and Visian ICL V4c implantations for high myopia.Twenty cases (20 eyes) with high myopia who received Visian ICL V4 implantation and 18 cases (18 eyes) with high myopia who received Visian ICL V4c implantation in our hospital from April 1, 2014 to November 31, 2016 were enrolled. In 1-month follow-up, near vision, best corrected distant visual acuity (BCVA), uncorrected distant visual acuity (UDVA), and wavefront aberrations were measured, and compensation factor was calculated...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28638843/susceptibility-to-cryptococcal-meningoencephalitis-associated-with-idiopathic-cd4-lymphopenia-and-secondary-germline-or-acquired-defects
#13
Anil A Panackal, Lindsey B Rosen, Gulbu Uzel, Michael J Davis, Guowu Hu, Adebowale Adeyemo, Fasil Tekola-Ayele, Andrea Lisco, Christopher Diachok, Jonathan D Kim, Dawn Shaw, Irini Sereti, Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig, John E Bennett, Peter R Williamson
Idiopathic CD4(+) lymphopenia (ICL) predisposes to opportunistic infections (OIs) but can often remain asymptomatic and does not have a strong association with monogenic mutations. Likewise, cryptococcal meningoencephalitis, the most common OI in ICL, is not strongly associated with monogenic mutations. In this study, we describe 2 patients with ICL plus an additional immune defect: one from an E57K genetic mutation in the nuclear factor-κβ essential modulator, and the other with acquired autoantibodies to granulocyte-macrophage colony-stimulating factor...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28634400/chronic-treatment-with-cisplatin-induces-chemoresistance-through-the-tip60-mediated-fanconi-anemia-and-homologous-recombination-repair-pathways
#14
Wen-Pin Su, Yen-Chih Ho, Cheng-Kuei Wu, Sen-Huei Hsu, Jia-Lin Shiu, Jheng-Cheng Huang, Song-Bin Chang, Wen-Tai Chiu, Jan-Jong Hung, Tsung-Lin Liu, Wei-Sheng Wu, Pei-Yu Wu, Wu-Chou Su, Jang-Yang Chang, Hungjiun Liaw
The Fanconi anemia pathway in coordination with homologous recombination is essential to repair interstrand crosslinks (ICLs) caused by cisplatin. TIP60 belongs to the MYST family of acetyltransferases and is involved in DNA repair and regulation of gene transcription. Although the physical interaction between the TIP60 and FANCD2 proteins has been identified that is critical for ICL repair, it is still elusive whether TIP60 regulates the expression of FA and HR genes. In this study, we found that the chemoresistant nasopharyngeal carcinoma cells, derived from chronic treatment of cisplatin, show elevated expression of TIP60...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28627616/distinct-cellular-phenotype-linked-to-defective-dna-interstrand-crosslink-repair-and-homologous-recombination
#15
Aleksandra M Gorniewska, Katarzyna Kluzek, Lidia Gackowska, Izabela Kubiszewska, Malgorzata Z Zdzienicka, Aneta Bialkowska
Repair of DNA interstrand crosslinks (ICLs) predominantly involves the Fanconi anemia (FA) pathway and homologous recombination (HR). The HR repair system eliminates DNA double strand breaks (DSBs) that emerge during ICLs removal. The current study presents a novel cell line, CL‑V8B, representing a new complementation group of Chinese hamster cell mutants hypersensitive to DNA crosslinking factors. CL‑V8B exhibits increased sensitivity to various DNA‑damaging agents, including compounds leading to DSBs formation (bleomycin and 6‑thioguanine), and is extremely sensitive to poly (ADP-ribose) polymerase inhibitor (>400‑fold), which is typical for HR‑defective cells...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28627569/porphyrin-based-photosensitizers-and-their-dna-conjugates-for-singlet-oxygen-induced-nucleic-acid-interstrand-crosslinking
#16
Eva M Llamas, João P C Tome, João M M Rodrigues, Tomás Torres, Annemieke Madder
The development of methods for the generation of site-selective interstrand crosslinks (ICLs) in synthetic oligonucleotides provides a platform for the study of ICL repair mechanisms and the stabilisation of DNA-based materials. Our group has previously reported on the use of a furan moiety as a masked reactive functionality for ICL generation and recently introduced the use of (1)O2 as an efficient light-induced oxidant. Here, the use of porphyrin-based photosensitizers (PSs) has been explored for ICL generation...
June 27, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28623094/structural-and-functional-relationships-of-fan1
#17
REVIEW
Hyeonseok Jin, Yunje Cho
FANCD2/FANCI-associated nuclease (FAN1) is a 5' flap structure-specific endonuclease and 5' to 3' exonuclease. This nuclease can resolve interstrand cross-links (ICLs) independently of the Fanconi anemia (FA) pathway and controls the progression of stalled replication forks in an FA-dependent manner, thereby maintaining chromosomal stability. Several FAN1 mutations are observed in various cancers and degenerative diseases. Recently, several crystal structures of the FAN1-DNA complexes have been reported, and to date, these represent the only structures for a DNA bound ICL-repair nuclease...
June 9, 2017: DNA Repair
https://www.readbyqxmd.com/read/28621132/one-pot-consecutive-sulfonamidation-ipso-cyclization-strategy-for-the-construction-of-azaspirocyclohexadienones
#18
Chada Raji Reddy, Ravi Ranjan, Santosh Kumar Prajapti, Kamalkishor Warudikar
Harnessing of Morita-Baylis-Hillman (MBH) carbonates of acetylenic aldehydes as handy synthons has allowed a facile synthesis of azaspirocyclohexadienones by sequential DABCO-promoted sulfonamidation/ICl-mediated ipso-iodocyclization reactions. A variety of MBH-carbonates having aryl or heteroaryl groups on the alkyne functionality fruitfully participated in the one-pot ipso-annulation reaction to provide the corresponding 3-iodo spirocyclohexadienones. The sulphonamide functionality was further utilized to construct the tricyclic fused-sultam framework...
June 27, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28611132/posterior-chamber-phakic-intraocular-lens-implantation-comparative-multicentre-study-in-351-eyes-with-low-to-moderate-or-high-myopia
#19
Kazutaka Kamiya, Kimiya Shimizu, Akihito Igarashi, Yoshihiro Kitazawa, Takashi Kojima, Tomoaki Nakamura, Yoshitaka Oka, Rei Matsumoto
AIM: To compare the clinical outcomes of posterior chamber phakic intraocular lens implantation with a central hole (Hole Implantable Collamer Lens (ICL), STAAR Surgical) for low-to-moderate myopia and for high myopia. METHODS: This multicentre retrospective case series comprised 351 eyes of 351 consecutive patients undergoing ICL implantation. Eyes were divided into groups based on preoperative degree of myopia: group 1; 57 eyes, manifest spherical equivalent less than -6 dioptres (D), and group 2; 294 eyes, -6 D or more...
June 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28607004/rpa-activates-the-xpf-ercc1-endonuclease-to-initiate-processing-of-dna-interstrand-crosslinks
#20
Ummi B Abdullah, Joanna F McGouran, Sanja Brolih, Denis Ptchelkine, Afaf H El-Sagheer, Tom Brown, Peter J McHugh
During replication-coupled DNA interstrand crosslink (ICL) repair, the XPF-ERCC1 endonuclease is required for the incisions that release, or "unhook", ICLs, but the mechanism of ICL unhooking remains largely unknown. Incisions are triggered when the nascent leading strand of a replication fork strikes the ICL Here, we report that while purified XPF-ERCC1 incises simple ICL-containing model replication fork structures, the presence of a nascent leading strand, modelling the effects of replication arrest, inhibits this activity...
July 14, 2017: EMBO Journal
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