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https://www.readbyqxmd.com/read/29021416/sp-thermal-comfort-sustained-by-cold-protective-clothing-in-arctic-open-pit-mining-a-thermal-manikin-and-questionnaire-study
#1
Kirsi Jussila, Sirkka Rissanen, Anna Aminoff, Jens Wahlström, Arild Vaktskjold, Ljudmila Talykova, Jouko Remes, Satu Mänttäri, Hannu Rintamäki
Workers in the Arctic open-pit mines are exposed to harsh weather conditions. Employers are required to provide protective clothing for workers. This can be the outer layer, but sometimes also inner or middle layers are provided. This study aimed to determine how the Arctic open-pit miners protect themselves against cold and the sufficiency, and the selection criteria of the garments. Workers' cold experiences and the clothing in four Arctic open-pit mines in Finland, Sweden, Norway and Russia were evaluated by a questionnaire (n=1323)...
October 11, 2017: Industrial Health
https://www.readbyqxmd.com/read/29020621/fanconi-anemia-associated-mutations-destabilize-rad51-filaments-and-impair-replication-fork-protection
#2
Karina Zadorozhny, Vincenzo Sannino, Ondrej Beláň, Jarmila Mlčoušková, Mário Špírek, Vincenzo Costanzo, Lumír Krejčí
Fanconi anemia (FA) is a genetic disorder characterized by a defect in DNA interstrand crosslink (ICL) repair, chromosomal instability, and a predisposition to cancer. Recently, two RAD51 mutations were reported to cause an FA-like phenotype. Despite the tight association of FA/HR proteins with replication fork (RF) stabilization during normal replication, it remains unknown how FA-associated RAD51 mutations affect replication beyond ICL lesions. Here, we report that these mutations fail to protect nascent DNA from MRE11-mediated degradation during RF stalling in Xenopus laevis egg extracts...
October 10, 2017: Cell Reports
https://www.readbyqxmd.com/read/29017571/dna-damage-response-and-cancer-therapeutics-through-the-lens-of-the-fanconi-anemia-dna-repair-pathway
#3
REVIEW
Sonali Bhattacharjee, Saikat Nandi
Fanconi Anemia (FA) is a rare, inherited genomic instability disorder, caused by mutations in genes involved in the repair of interstrand DNA crosslinks (ICLs). The FA signaling network contains a unique nuclear protein complex that mediates the monoubiquitylation of the FANCD2 and FANCI heterodimer, and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. FA proteins act at different steps of ICL repair in sensing, recognition and processing of DNA lesions...
October 10, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28991339/pupil-dynamics-induced-by-light-reflex-after-posterior-chamber-phakic-intraocular-lens-implantation
#4
Kazuko Totsuka, Hitoshi Ishikawa, Kazutaka Kamiya, Nobuyuki Shoji, Kimiya Shimizu
PURPOSE: To assess the light reflex of the pupil after Implantable Collamer Lens (ICL) (KS-aquaPORT; STAAR Surgical, Nidau, Switzerland) implantation to determine whether the ICL implantation might affect the pupil dynamics. METHODS: This study examined 28 eyes of 28 consecutive patients who underwent implantation of the posterior phakic ICL for the correction of myopia and astigmatism. Patient age at the time of surgery was 31.1 ± 6.8 years (range: 25 to 42 years)...
October 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28977694/denosumab-related-osteonecrosis-of-the-jaw-a-retrospective-study
#5
Egloff-Juras Claire, Gallois Aurélie, Salleron Julia, Massard Vincent, Dolivet Gilles, Guillet Julie, Phulpin Bérengère
BACKGROUND: Osteonecrosis of the jaw is a very delicate side effect of Denosumab. The aim of this retrospective study is to assess the occurrence rate of Denosumab-related osteonecrosis of the jaw (DRONJ) at the Cancer Institute of Lorraine (ICL) and to highlight necrosis risk factors. METHODS: To that purpose we analyzed the medical records of 249 consecutive patients treated with Denosumab at the ICL during the past 5 years. Patients who received oro-facial radiotherapy or a previous treatment with a bisphosphonate were excluded...
October 4, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28966006/withdrawn-beyond-interstrand-crosslinks-repair-contribution-of-fancd2-and-other-fanconi-anemia-proteins-to-the-replication-of-dna
#6
Maria B Federico, Paola Campodónico, Natalia S Paviolo, Vanesa Gottifredi
The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/ 10.1016/j.mrfmmm.2017.09.006. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
September 25, 2017: Mutation Research
https://www.readbyqxmd.com/read/28958376/idiopathic-cd4-lymphocytopenia-pathogenesis-etiologies-clinical-presentations-and-treatment-strategies
#7
Hale Yarmohammadi, Charlotte Cunningham-Rundles
BACKGROUND: Idiopathic CD4 lymphocytopenia (ICL) is a rare condition characterized by an unexplained deficit of circulating CD4 T cells leading to increased risk of serious opportunistic infections. The pathogenesis, etiology, clinical presentation, and best treatment options remain unclear. OBJECTIVE: To describe the clinical presentation, treatment strategies, and outcome of patients with ICL seen in a single referral center. METHODS: In a retrospective study, from January 1993 to January 2014, the demographic characteristics, clinical presentation, and treatments of patients diagnosed with ICL were reviewed...
October 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28951331/design-development-and-characterization-of-synthetic-bruch-s-membranes
#8
Denver C Surrao, Ursula Greferath, Yu-Qian Chau, Stuart J Skabo, Mario Huynh, Kinnari J Shelat, Ioannis J Limnios, Erica L Fletcher, Qin Liu
Age-related macular degeneration (AMD) is a leading cause of blindness, and dry AMD has no effective treatment. Retinal constructs comprising retinal pigment epithelium (RPE) cells supported by electrospun scaffolds have been investigated to treat dry AMD. However, electrospun scaffolds studied to-date do not mimic the structural microenvironment of human Bruch's membrane (BM), essential for native-like RPE monolayers. The aim of this study was to develop a structurally biomimetic scaffold designed to support a functional RPE monolayer, comprising porous, electrospun nanofibrous membranes (ENMs), coated with laminin, mimicking the inner collagenous layer (ICL) and basal RPE lamina respectively, the cell supporting layers of the BM...
September 23, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28938540/microrna-128-3p-regulates-mitomycin-c-induced-dna-damage-response-in-lung-cancer-cells-through-repressing-sptan1
#9
Rui Zhang, Chang Liu, Yahan Niu, Ying Jing, Haiyang Zhang, Jin Wang, Jie Yang, Ke Zen, Junfeng Zhang, Chen-Yu Zhang, Donghai Li
The DNA damage response is critical for maintaining genome integrity and preventing damage to DNA due to endogenous and exogenous insults. Mitomycin C (MMC), a potent DNA cross-linker, is used as a chemotherapeutic agent because it causes DNA inter-strand cross-links (DNA ICLs) in cancer cells. While many microRNAs, which may serve as oncogenes or tumor suppressors, are grossly dysregulated in human cancers, little is known about their roles in MMC-treated lung cancer. Here, we report that miR-128-3p can attenuate repair of DNA ICLs by targeting SPTAN1 (αII Sp), resulting in cell cycle arrest and promoting chromosomal aberrations in lung cancer cells treated with MMC...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937154/structural-basis-of-interstrand-cross-link-repair-by-o-6-alkylguanine-dna-alkyltransferase
#10
Alexey Y Denisov, Francis P McManus, Derek K O'Flaherty, Anne M Noronha, Christopher J Wilds
DNA interstrand cross-links (ICL) are among the most cytotoxic lesions found in biological systems. O(6)-Alkylguanine DNA alkyltransferases (AGTs) are capable of removing alkylation damage from the O(6)-atom of 2'-deoxyguanosine and the O(4)-atom of thymidine. Human AGT (hAGT) has demonstrated the ability to repair an interstrand cross-linked duplex where two O(6)-atoms of 2'-deoxyguanosine were tethered by a butylene (XLGG4) or heptylene (XLGG7) linkage. However, the analogous ICL between the O(4)-atoms of thymidine was found to evade repair...
October 11, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28934497/systematic-analysis-of-dna-crosslink-repair-pathways-during-development-and-aging-in-caenorhabditis-elegans
#11
David M Wilson, Matthias Rieckher, Ashley B Williams, Björn Schumacher
DNA interstrand crosslinks (ICLs) are generated by endogenous sources and chemotherapeutics, and pose a threat to genome stability and cell survival. Using Caenorhabditis elegans mutants, we identify DNA repair factors that protect against the genotoxicity of ICLs generated by trioxsalen/ultraviolet A (TMP/UVA) during development and aging. Mutations in nucleotide excision repair (NER) components (e.g. XPA-1 and XPF-1) imparted extreme sensitivity to TMP/UVA relative to wild-type animals, manifested as developmental arrest, defects in adult tissue morphology and functionality, and shortened lifespan...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28933042/anterior-chamber-changes-after-implantable-collamer-lens-implantation-in-high-myopia-using-pentacam-a-prospective-study
#12
Mohamed Nagy Elmohamady, Walid Abdelghaffar
INTRODUCTION: The objective of this study was to evaluate the changes of the anterior chamber (AC) of the eye after implantable Collamer lens (ICL) implantation in high myopia by using the Pentacam. METHODS: The prospective study included 34 high myopic patients (34 eyes). All patients were treated with Visian implantable Collamer lens (ICL) (Staar Surgical Co.) implantation. The Pentacam (Oculus) was used for all cases preoperatively and 1, 3 and 6 months postoperatively...
September 20, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28928494/systematic-review-and-meta-analyses-of-the-difference-between-the-spinal-level-of-the-palpated-and-imaged-iliac-crests
#13
Robert Cooperstein, Felisha Truong
OBJECTIVE: The purpose of this study was to undertake a systematic review of the literature to determine and compare, for patient sub-groups, the spinal level of the iliac crests as commonly measured through manual palpation and radiographic imaging procedures. METHODS: Relevant citations were retrieved by searching the PubMed, ICL, CINAHL, AMED, Osteopathic Research Web, OstMed, and MANTIS biomedical databases, and included articles were rated for quality. Search terms included Tuffier*, intercristal line, intercrestal line, Jacoby's line, lumbar spine, lumbar landmark, pelvic landmark, palpation, and TL (Tuffier's Line)...
August 2017: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28900204/monovision-by-implantation-of-posterior-chamber-phakic-intraocular-lens-with-a-central-hole-hole-icl-for-early-presbyopia
#14
Kazutaka Kamiya, Masahide Takahashi, Natsumi Takahashi, Nobuyuki Shoji, Kimiya Shimizu
This study was aimed to evaluate visual performance at near to far distances in early presbyopic patients undergoing monovision by implantation of an ICL with a central hole (hole ICL). This pilot study comprised thirty-four eyes of 17 early presbyopic patients (age, 40 to 53 years) who underwent hole ICL implantation, and whose targeted refraction was set at emmetropia for the dominant eye, and at slight myopia (-0.5 to -1.0 diopters (D)) for the non-dominant eye. Corrected distance visual acuity was significantly improved, from -0...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887673/-intraocular-pressure-after-implantation-of-an-icl-with-aquaport-development-of-intraocular-pressure-after-implantation-of-an-icl-model-v4c-with-aquaport-without-iridotomy
#15
B Repplinger, T Kohnen
BACKGROUND AND OBJECTIVE: The latest version of the intraocular lens (ICL V4c) has a central hole (aquaport) that avoids a pupillary block. Due to this laser iridotomy or intraoperative surgical peripheral iridectomy are no longer required. In this study, we examined the intraocular pressure (IOP) after implantation of the ICL with aquaport, with special reference to the development of a possible pupillary block glaucoma. MATERIAL AND METHODS: This retrospective non-randomized study included 87 eyes from 46 patients (consecutive case series)...
September 8, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28880336/toric-icl-implantation-after-sequential-intracorneal-ring-segments-implantation-and-corneal-cross-linking-in-keratoconus-2-year-follow-up
#16
Youssef Abdelmassih, Sylvain El-Khoury, Elias Chelala, Elise Slim, Carole G Cherfan, Elias Jarade
PURPOSE: To evaluate 6-month and 2-year safety and clinical outcomes of Visian toric Implantable Collamer Lens (toric ICL) (STAAR Surgical, Monrovia, CA) implantation for the treatment of residual refractive errors after sequential intracorneal ring segments (ICRS) insertion and cross-linking (CXL) in keratoconus. METHODS: This consecutive case series included the results of a three-step ICRS-CXL-toric ICL procedure in 16 eyes of 13 patients with moderate to severe keratoconus (stages II and III of Amsler-Krumeich classification)...
September 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28880335/refractive-outcomes-of-20-eyes-undergoing-icl-implantation-for-correction-of-hyperopic-astigmatism
#17
Efekan Coskunseven, Isilay Kavadarli, Onurcan Sahin, Belma Kayhan, Ioannis Pallikaris
PURPOSE: To analyze 1-week, 1-month, and 12-month postoperative refractive outcomes of eyes that under-went ICL implantation to correct hyperopic astigmatism. METHODS: The study enrolled 20 eyes of patients with an average age of 32 years (range: 21 to 40 years). The outcomes of spherical and cylindrical refraction, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), vault, and angle parameters were evaluated 1 week, 1 month, and 12 months postoperatively...
September 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28879898/progressive-multifocal-leukoencephalopathy-in-a-44-year-old-male-with-idiopathic-cd4-t-lymphocytopenia-treated-with-mirtazapine-and-mefloquine
#18
Aruna Nambirajan, Vaishali Suri, Vijay Kataria, Mehar C Sharma, Vinay Goyal
Progressive multifocal leukoencephalopathy (PML) is an opportunistic viral infection of the central nervous system caused by the reactivation of John Cunningham virus (JCV) in immunocompromised patients, most commonly in human immunodeficiency virus (HIV) infection, and less commonly in those receiving various immunosuppressive regimens. Prognosis of untreated PML is grave and the mainstay of treatment is the reversal of immunosuppression, usually by institution of antiretroviral drugs in HIV patients and cessation of immunosuppressive therapies in others...
September 2017: Neurology India
https://www.readbyqxmd.com/read/28855448/caffeine-has-a-synergistic-anticancer-effect-with-cisplatin-via-inhibiting-fanconi-anemia-group-d2-protein-monoubiquitination-in-hepatocellular-carcinoma-cells
#19
Yuichiro Oda, Muneaki Hidaka, Akito Suzuki
Cisplatin is an anticancer agent and induces DNA interstrand cross-links (ICLs). ICLs activate various signaling processes and induce DNA repair pathways, including the Fanconi anemia (FA) pathway. FA complementation group D2 (FANCD2) is monoubiquitinated in response to DNA damage, leading to activation of the DNA double-strand-break repair protein, RAD51. Caffeine increases the anticancer activity of cisplatin by inhibiting DNA repair; however, details of the mechanism remain unclear. We investigated the mechanism responsible for the synergistic anticancer effect of cisplatin and caffeine in HepG2 human hepatocellular carcinoma cells, focusing on the FA pathway...
August 31, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28846701/a-comparison-of-visual-outcome-and-rotational-stability-of-two-types-of-toric-implantable-collamer-lenses-ticl-v4-versus-v4c
#20
Joo Hyun, Dong Hui Lim, Doo Ri Eo, Sungsoon Hwang, Eui-Sang Chung, Tae-Young Chung
PURPOSE: To compare the efficacy and rotational stability after implantation of two types of toric implantable collamer lenses (Toric ICL™(TICL);V4 and V4c, STAAR Surgical Co.). STUDY DESIGN: Retrospective case series. METHODS: This retrospective study evaluated total 48 eyes of 48 patients who underwent the implantation with V4 and V4c TICL with a central hole; A twenty-four eyes of 24 patients with V4 TICL and 24 eyes of 24 patients with V4c TICL with a central hole...
2017: PloS One
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