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https://www.readbyqxmd.com/read/28432524/correlation-of-serum-mmp3-and-other-biomarkers-with-clinical-outcomes-in-patients-with-ankylosing-spondylitis-a-pilot-study
#1
Dongyi He, Qi Zhu, Quan Zhou, Qing Qi, Hongmei Sun, Liza M Zachariah, Grace Wang, John D Reveille, Yongtao Guan, Xiaodong Zhou
The studies aimed to assess a set of biomarkers for their correlations with disease activity/severity of patients with ankylosing spondylitis (AS). A total of 24 AS patients were treated with etanercept and prospectively followed for 12 weeks. Serum levels of TNF-α, IFN-γ, TGF-β, IL6, IL15, IL17, MMP3, and MICA were measured at baseline and after treatment. The change of these biomarkers was analyzed for correlations with MRI indices for joint inflammation, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, AS Disease Activity Score, serum CRP, and ESR...
April 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28431026/minimally-invasive-sacroiliac-joint-fusion-radiofrequency-denervation-and-conservative-management-for-sacroiliac-joint-pain-6-year-comparative-case-series
#2
Vicente Vanaclocha, Juan Manuel Herrera, Nieves Sáiz-Sapena, Marlon Rivera-Paz, Francisco Verdú-López
BACKGROUND: Sacroiliac joint (SIJ) pain is an under-recognized condition. Substantial information supports the safety and effectiveness of SIJ fusion (SIJF). Long-term follow-up after SIJF has not been reported. OBJECTIVE: To determine responses to conservative management (CM), SIJ denervation, and SIJF in patients with SIJ pain unresponsive to CM. METHODS: Retrospective study with long-term (up to 6 yr) follow-up of 137 patients with SIJ pain seen in an outpatient neurosurgery clinic who received either CM (n = 63), sacroiliac denervation (n = 47), or minimally invasive SIJF (n = 27)...
April 20, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28426912/the-association-between-inflammatory-back-pain-characteristics-and-mri-findings-in-the-spine-and-sacroiliac-joints
#3
Bodil Arnbak, Anne G Jurik, Tue S Jensen, Claus Manniche
OBJECTIVE: To investigate the association between MRI findings at the sacroiliac joints (SIJs) and vertebral endplates and pain characteristics assumed to be indicative of axial inflammation. METHODS: Patients aged 18-40 years with persistent low back pain referred to an outpatient spine clinic participated, including an unknown proportion of axial spondyloarthritis patients. Data included MRI of the spine and SIJs and self-reported responses to questions covering the Calin, Berlin, ASAS and Bailly inflammatory back pain (IBP) definitions...
April 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28422854/immunohistological-analysis-of-active-sacroiliitis-in-patients-with-axial-spondyloarthritis
#4
Jianhua Peng, Yao Gong, Yuping Zhang, Danmin Wang, Zhengyu Xiao
The sacroiliac joints (SIJs) are one of the most common sites involved in axial spondyloarthritis (axSpA), and there are few studies on the histopathology of the SIJ in this group of patients.Mononuclear cell infiltrates in the bone marrow and fibrous tissue resembling a pannus formation were the pathological features of early sacroiliitis in our previous study. We undertook a further immunohistological evaluation of these features in patients with axSpA.Biopsy specimens from the SIJ of 6 patients with established ankylosing spondylitis (AS) and 13 patients with nonradiographic axial spondyloarthritis (nr-axSpA) were analyzed...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28410481/leg-symptoms-associated-with-sacroiliac-joint-disorder-and-related-pain
#5
Eiichi Murakami, Toshimi Aizawa, Daisuke Kurosawa, Kyoko Noguchi
OBJECTIVE: The symptoms of sacroiliac joint (SIJ) disorders are usually detected in the buttock and groin, and occasionally referred to the thigh and leg. However, lumbar disorders also cause symptoms in these same body regions. The presence of a characteristic, symptomatic pattern in the legs would be useful for diagnosing SIJ disorders. This study aimed to identify specific leg symptoms in patients with SIJ pain originating from the posterior sacroiliac ligament and determine the rate of occurrence of these symptoms...
March 30, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28387855/non-radiographic-axial-spondyloarthritis-patients-without-initial-evidence-of-inflammation-may-develop-objective-inflammation-over-time
#6
Xenofon Baraliakos, Joachim Sieper, Su Chen, Aileen L Pangan, Jaclyn K Anderson
Objectives.: In patients with active axial spondyloarthritis (axSpA), inflammation in the SIJ or spine on MRI, an elevated CRP level or both are considered useful objective assessments for disease activity and initiation of TNF antagonists. The aim of this post hoc analysis of the randomized, double-blind ABILITY-1 study (NCT00939003) was to assess changes in objective inflammation over time. Methods.: Patients with non-radiographic axSpA (nr-axSpA) were randomized to receive adalimumab 40 mg every other week or placebo for 12 weeks in ABILITY-1...
April 5, 2017: Rheumatology
https://www.readbyqxmd.com/read/28377866/revision-of-minimally-invasive-sacroiliac-joint-fixation-technical-considerations-and-case-studies-using-decortication-and-threaded-implant-fixation
#7
Brett MenMuir, Louis C Fielding
BACKGROUND: Sacroiliac joint (SIJ) disease is increasingly recognized as a common source of low back pain. Arthrodesis of the SIJ has been shown to be clinically effective for this condition. In the last decade, minimally invasive (MI) SIJ fusion procedures have been developed to achieve the clinical effectiveness of open fusion procedures, with lower operative morbidity and faster recovery. However, SIJ fusion patients occasionally present with symptomatic nonunions necessitating revision...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28377863/surgical-revision-after-sacroiliac-joint-fixation-or-fusion
#8
Katie Spain, Timothy Holt
BACKGROUND: Minimally invasive sacroiliac joint (SIJ) fusion has been shown to be safe and effective for the treatment of SIJ dysfunction. Multiple devices are available to perform SIJ fixation or fusion. Surgical revision rates after these procedures have not been directly compared. METHODS: We retrospectively identified all patients in our practice who underwent SIJ fixation or fusion between 2003 and 2015. Using both chart review and focused contact with individual patients, we determined the likelihood of surgical revision...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28371491/imaging-findings-suggestive-of-axial-spondyloarthritis-in-diffuse-idiopathic-skeletal-hyperostosis
#9
Augustin Latourte, Stéphane Charlon, Adrien Etcheto, Antoine Feydy, Yannick Allanore, Maxime Dougados, Anna Molto
OBJECTIVE: 1) To describe the MRI findings in diffuse idiopathic skeletal hyperostosis (DISH) patients and 2) to assess the proportion of DISH patients whose MRI findings would fulfill the Assessment of SpondyloArthritis international Society (ASAS) criteria for a positive MRI of axial spondyloarthritis (axSpA). METHODS: This study involved all DISH patients who had a spine or sacroiliac joints (SIJ) MRI performed between January 2009 and December 2014. Sociodemographical and clinical data were collected...
March 28, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28365579/the-use-of-magnetic-resonance-imaging-in-axial-spondyloarthritis-time-to-bridge-the-gap-between-radiologists-and-rheumatologists
#10
Alexander N Bennett, Helena Marzo-Ortega, Daljit Kaur-Papadakis, Amer Rehman
OBJECTIVE: Magnetic resonance imaging (MRI) is involved in the assessment of axial spondyloarthritis (axSpA); however, anecdotal evidence suggests diverse practice among radiologists. The objective of this study was to describe current practice in the use of MRI for assessment of axSpA by UK radiologists. METHODS: Six hundred ninety-nine UK radiologists were invited to complete an online survey. Availability of MR scanners, familiarity with axSpA disease-specific lesions, and MRI protocols and definitions of positive sacroiliac joint (SIJ) or spinal MRI were assessed...
April 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28350586/predictors-of-outcome-in-conservative-and-minimally-invasive-surgical-management-of-pain-originating-from-the-sacroiliac-joint-a-pooled-analysis
#11
Julius Dengler, Bradley Duhon, Peter Whang, Clay Frank, John Glaser, Bengt Sturesson, Steven Garfin, Daniel Cher, Aaron Rendahl, David Polly
STUDY DESIGN: A pooled patient-level analysis of two multicenter randomized controlled trials and one multicenter single-arm prospective trial. OBJECTIVE: To identify predictors of outcome of conservative and minimally invasive surgical management of pain originating from the sacroiliac joint (SIJ). SUMMARY OF BACKGROUND DATA: Three recently published prospective trials have shown that minimally invasive SIJ fusion (SIJF) using triangular titanium implants produces better outcomes than conservative management for patients with pain originating from the SIJ...
March 27, 2017: Spine
https://www.readbyqxmd.com/read/28340063/conventional-simplicity-iii-and-cooled-sinergy-radiofrequency-for-sacroiliac-joint-denervation-one-year-retrospective-study-comparing-two-devices
#12
Andrea Tinnirello, Sandra Barbieri, Manuel Todeschini, Maurizio Marchesini
Objective. : To compare two radiofrequency (RF) devices, Simplicity III (conventional RF), and SInergy (cooled RF), which are specifically designed to denervate the sacroiliac joint (SIJ). Design. : Retrospective observational study. Setting. : Italian National Health Service Public Hospital. Subjects.:  Forty-three patients with SIJ-derived pain refractory to conservative treatment; 21 and 22 patients, respectively, received Simplicity III or SInergy to denervate the SIJ...
March 15, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28243380/patient-reported-outcomes-from-sacroiliac-joint-fusion
#13
Vamsi K Kancherla, Shane M McGowan, Brittany N Audley, Gbolabo Sokunbi, Steven T Puccio
STUDY DESIGN: Retrospective, case series. PURPOSE: The purpose of this study is to determine morbidity, complications, and patient reported outcomes from minimally invasive sacroiliac joint (SIJ) fusion. OVERVIEW OF LITERATURE: Lumbar back pain emanating from the SIJ can be surgically treated via a percutaneous approach in the appropriately selected patient with minimal morbidity and acceptable functional outcomes. METHODS: Patients diagnosed by >2 physical examination maneuvers and subjective relief from a computed tomography-guided lidocaine-bupivacaine-steroid injection underwent SIJ fusion after failing conservative management with a combination of oral anti-inflammatory medications, physical therapy, and pelvic belt stabilization...
February 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28216399/minimally-invasive-sacroiliac-joint-fusion-using-a-novel-hydroxyapatite-coated-screw-preliminary-1-year-clinical-and-radiographic-results-of-a-2-year-prospective-study
#14
Louis H Rappoport, Ingrid Y Luna, Gita Joshua
OBJECTIVE: Proper diagnosis and treatment of sacroiliac joint (SIJ) pain remains a clinical challenge. Dysfunction of SIJ can produce pain in the lower back, buttocks, and extremities. Triangular titanium implants for minimally invasive surgical arthrodesis have been available for several years with reputed high levels of success and patient satisfaction. This study reports on a novel hydroxyapatite-coated screw for surgical treatment of SIJ pain. METHODS: Data were prospectively collected on 32 consecutive patients who underwent minimally invasive SIJ fusion with a novel hydroxyapatite-coated screw...
February 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28205376/drug-drug-interactions-in-pediatric-oncology-patients
#15
T E Balk, I H van der Sijs, T van Gelder, J J B Janssen, I M van der Sluis, R W F van Leeuwen, F K Engels
BACKGROUND: Drug-drug interactions (DDIs) can negatively affect pharmacotherapy. However, pediatric DDI studies are scarce. We undertook an exploratory study to investigate prevalence and clinical relevance of DDIs between cytostatic and noncytostatic drugs in outpatient pediatric oncology patients. PROCEDURE: After informed consent and inclusion, the following information was collected: currently prescribed noncytostatic and cytostatic drugs, comorbidities, and use of over-the-counter (OTC) drugs, complementary and alternative medicines (CAMs), and dietary supplements...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28159215/probiotic-and-antioxidant-properties-of-selenium-enriched-lactobacillus-brevis-lse-isolated-from-an-iranian-traditional-dairy-product
#16
Mojtaba Shakibaie, Tayebe Mohammadi-Khorsand, Mahboubeh Adeli-Sardou, Mandana Jafari, Sahar Amirpour-Rostami, Alieh Ameri, Hamid Forootanfar
The present study was designed to isolate a highly selenium-tolerant lactobacillus strain from an Iranian traditional dairy product named as Spar. Different criteria such as tolerance to the low pH, simulated gastric juice (SGJ), simulated intestinal juice (SIJ) and bile salts tolerance as well as Caco-2 cell adhesion assay were examined to evaluate the probiotic potentials of the selected isolate. Furthermore, the antioxidant properties of the isolate cultivated in medium containing and free of SeO3(2-) ions were evaluated using DPPH scavenging and reducing power assays...
March 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28125786/ct-abnormalities-in-the-sacroiliac-joints-of-patients-with-diffuse-idiopathic-skeletal-hyperostosis
#17
Naama Leibushor, Einat Slonimsky, Dvora Aharoni, Merav Lidar, Iris Eshed
OBJECTIVE: The purpose of this study is to characterize sacroiliac joints (SIJs) findings at CT of patients with diffuse idiopathic skeletal hyperostosis (DISH), a condition characterized (using the Resnick classification criteria) by ossification of at least four contiguous vertebrae in the thoracic spine and preserved disk space, but without radiographic evidence of intraarticular SIJ abnormalities. MATERIALS AND METHODS: Pelvic CT examinations of 104 patients with DISH (fulfilling the Resnick criteria on spinal CT) and 106 age- and sex-matched control subjects whose entire spine lacked CT evidence of DISH (total, 149 men and 61 women; mean [± SD] age, 72...
April 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28039353/fluoroscopy-guided-sacroiliac-intraarticular-injection-via-the-middle-portion-of-the-joint
#18
Daisuke Kurosawa, Eiichi Murakami, Toshimi Aizawa
OBJECTIVE : Sacroiliac intraarticular injection is necessary to confirm sacroiliac joint (SIJ) pain and is usually performed via the caudal one-third portion of the joint. However, this is occasionally impossible for anatomical reasons, and the success rate is low in clinical settings. We describe a technique via the middle portion of the joint. DESIGN : Observational study. SUBJECTS : Enrolled were 69 consecutive patients (27 men and 42 women, with an average age of 53 years) in whom the middle portion of 100 joints was targeted...
December 30, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27999021/development-of-operationalized-intravenous-to-oral-antibiotic-switch-criteria
#19
H Akhloufi, M Hulscher, D C Melles, J M Prins, H van der Sijs, A Verbon
OBJECTIVES: Despite huge overlap in suggested criteria for a safe intravenous (iv)-to-oral antibiotic switch, there is considerable variation in their operationalization. The objective of this study was to develop a set of measurable conditions that should be met in adult hospitalized patients for a safe iv-to-oral switch. METHODS: A RAND-modified Delphi procedure was performed to develop a set of operationalized iv-to-oral switch criteria. Switch criteria and their accompanying suggested measurable conditions were extracted from the literature and appraised by a multidisciplinary expert panel during two questionnaire rounds with a face-to-face meeting between these two rounds...
December 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27974096/positive-correlation-between-inflammation-on-sacroiliac-joint-mri-and-serum-c-terminal-telopeptide-of-type-i-collagen-in-ankylosing-spondylitis-but-not-in-non-radiographic-axial-spondyloarthritis
#20
Kwi Young Kang, Joon-Yong Jung, Yeon Sik Hong, Ji Hyeon Ju, Sung-Hwan Park
OBJECTIVES: To identify the clinical disease activity scores and laboratory markers that best reflect magnetic resonance imaging (MRI)-determined sacroiliac joint (SIJ) inflammation in ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). METHODS: This cross-sectional study included all consecutive patients who presented with axial spondyloarthritis in 2013-2015. All underwent SIJ MRI. The bone marrow oedema in the inflammatory lesions on MRI was scored using the SPondyloArthritis Research Consortium of Canada (SPARCC) method...
December 14, 2016: Clinical and Experimental Rheumatology
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