keyword
MENU ▼
Read by QxMD icon Read
search

spinal patients outcome research trial

keyword
https://www.readbyqxmd.com/read/27919862/spinal-cord-injury-assessing-tolerability-and-use-of-combined-rehabilitation-and-neuroaid-saturn-study-protocol-of-an-exploratory-study-in-assessing-the-safety-and-efficacy-of-neuroaid-amongst-people-who-sustain-severe-spinal-cord-injury
#1
Ramesh Kumar, Ohnmar Htwe, Azmi Baharudin, Mohammad Hisam Ariffin, Shaharuddin Abdul Rhani, Kamalnizat Ibrahim, Aishah Rustam, Robert Gan
BACKGROUND: Spinal cord injury (SCI) is a devastating condition with limited therapeutic options despite decades of research. Current treatment options include use of steroids, surgery, and rehabilitation. Nevertheless, many patients with SCI remain disabled. MLC601 (NeuroAiD), a combination of natural products, has been shown to be safe and to aid neurological recovery after brain injuries and may have a potential role in improving recovery after SCI. OBJECTIVE: The aim of this study is to evaluate the safety and efficacy of NeuroAiD amongst people who sustain SCI in the study setting...
December 5, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27849674/lumbar-spinal-stenosis-how-is-it-classified
#2
Gregory D Schroeder, Mark F Kurd, Alexander R Vaccaro
The prevalence of lumbar spinal stenosis is approximately 9.3%, with people most commonly affected in the sixth or seventh decade of life. Patients often have pain, cramping, and weakness in their legs that is worsened with standing and walking. Although the Spine Patient Outcomes Research Trial clearly demonstrated that surgery improves health-related quality of life, treatment for lumbar spinal stenosis varies widely from the type of decompression performed to the need for fusion. This variability can be attributed largely to the lack of an accepted classification system...
December 2016: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/27831984/baseline-patient-reported-outcomes-correlate-weakly-with-radiographic-parameters-a-multicenter-prospective-nih-adult-symptomatic-lumbar-scoliosis-study-of-286-patients
#3
Todd M Chapman, Christine R Baldus, Jon D Lurie, Steven D Glassman, Frank J Schwab, Christopher I Shaffrey, Virginie Lafage, Oheneba Boachie-Adjei, Han J Kim, Justin S Smith, Charles H Crawford, Lawrence G Lenke, Jacob M Buchowski, Charles Edwards, Tyler Koski, Stefan Parent, Stephen Lewis, Daniel G Kang, Jamal McClendon, Lionel Metz, Lukas P Zebala, Michael P Kelly, Kevin F Spratt, Keith H Bridwell
STUDY DESIGN: Prospective, cross-sectional study. OBJECTIVE: The aim of the study was to determine which radiographic parameters drive patient-reported outcomes (PROs) in primary presentation adult symptomatic lumbar scoliosis (ASLS). SUMMARY OF BACKGROUND DATA: Previous literature suggests correlations between PROs and sagittal plane deformity (sagittal vertical axis [SVA], pelvic incidence-lumbar lordosis [PI-LL] mismatch, pelvic tilt [PT])...
November 15, 2016: Spine
https://www.readbyqxmd.com/read/27805416/translational-development-of-splice-modifying-antisense-oligomers
#4
S Fletcher, M I Bellgard, L Price, A P Akkari, S D Wilton
Antisense nucleic acid analogues can interact with pre-mRNA motifs and influence exon or splice site selection and thereby alter gene expression. Design of antisense molecules to target specific motifs can result in either exon exclusion or exon inclusion during splicing. Novel drugs exploiting the antisense concept are targeting rare, life-limiting diseases; however, the potential exists to treat a wide range of conditions by antisense-mediated splice intervention. Areas covered: In this review, the authors discuss the clinical translation of novel molecular therapeutics to address the fatal neuromuscular disorders Duchenne muscular dystrophy and spinal muscular atrophy...
November 2, 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27801521/surgical-options-for-lumbar-spinal-stenosis
#5
REVIEW
Gustavo C Machado, Paulo H Ferreira, Rafael Ij Yoo, Ian A Harris, Marina B Pinheiro, Bart W Koes, Maurits W van Tulder, Magdalena Rzewuska, Christopher G Maher, Manuela L Ferreira
BACKGROUND: Hospital charges for lumbar spinal stenosis have increased significantly worldwide in recent times, with great variation in the costs and rates of different surgical procedures. There have also been significant increases in the rate of complex fusion and the use of spinal spacer implants compared to that of traditional decompression surgery, even though the former is known to incur costs up to three times higher. Moreover, the superiority of these new surgical procedures over traditional decompression surgery is still unclear...
November 1, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27769304/3d-printing-techniques-in-a-medical-setting-a-systematic-literature-review
#6
Philip Tack, Jan Victor, Paul Gemmel, Lieven Annemans
BACKGROUND: Three-dimensional (3D) printing has numerous applications and has gained much interest in the medical world. The constantly improving quality of 3D-printing applications has contributed to their increased use on patients. This paper summarizes the literature on surgical 3D-printing applications used on patients, with a focus on reported clinical and economic outcomes. METHODS: Three major literature databases were screened for case series (more than three cases described in the same study) and trials of surgical applications of 3D printing in humans...
October 21, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/27716409/a-systematic-review-on-the-effectiveness-of-back-protectors-for-motorcyclists
#7
Rafael Ekmejian, Pooria Sarrami, Justine M Naylor, Ian A Harris
BACKGROUND: Motorcyclists are a vulnerable road-user population who are overrepresented in traffic injuries. Utilisation of back protectors may be an effective preventive measure for spine injuries in motorcyclists. Since use of back protectors is increasing it is important that clinical evidence supports their use. The study aimed to investigate the current evidence on the ability of back protectors to reduce the rate of back injuries and patient mortality in motorcycle crashes. METHODS: A systematic literature search was conducted using various electronic databases...
October 4, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27716168/a-protocol-of-a-randomized-controlled-multicenter-trial-for-surgical-treatment-of-lumbar-spondylolisthesis-the-lumbar-interbody-fusion-trial-lift
#8
Suzanne L de Kunder, Kim Rijkers, Sander M J van Kuijk, Silvia M A A Evers, Rob A de Bie, Henk van Santbrink
BACKGROUND: With a steep increase in the number of instrumented spinal fusion procedures, there is a need for comparative data to develop evidence based treatment recommendations. Currently, the available data on cost and clinical effectiveness of the two most frequently performed surgeries for lumbar spondylolisthesis, transforaminal lumbar interbody fusion (TLIF) and posterior lumbar interbody fusion (PLIF), are not sufficient. Therefore, current guidelines do not advise which is the most appropriate surgical treatment strategy for these patients...
October 6, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27677019/innovative-method-for-motor-functions-evaluation-in-sma-type-2-and-3-patients
#9
Carole Vuillerot, D Vincent-Genod, G Thomann, J Coton
OBJECTIVE: Physiotherapists are demanding of valid outcome measures to assess the evolution of their patient's motor functions in order to precisely describe the effects of treatments and the progress of diseases. Hence, several scales such as the motor function measure (MFM) have been developed with the aim to measure, with validity and reproducibility and sensitivity, the motor functions of patients with neuromuscular disease. The originality of our approach is to quantitatively measure the children's motor functions with a low-cost, non-invasive and plug and play technological tool that avoid the uncertain characteristic of human evaluation and increase children's involvement...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676766/peer-supported-self-management-to-facilitate-community-re-entry-after-discharge-from-spinal-cord-injury-rehabilitation-engaging-peers-as-change-agents-and-research-partners
#10
Michael Jones, Julie Gassaway
OBJECTIVE: Peer support is an important adjunct to clinical care for people with disabilities, and may help address barriers to community reintegration. Peers offer positive role models and the benefit of learning from shared experiences of living with disability. Despite potential benefits, peer support is not consistently integrated in the rehabilitation process. This presentation describes three interventions recommended by patients, and directed by peer mentors, to promote successful community transition after rehabilitation for traumatic spinal cord injury (SCI)...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27556002/neurogenic-fever-after-acute-traumatic-spinal-cord-injury-a-qualitative-systematic-review
#11
REVIEW
Katherine E Savage, Christina V Oleson, Gregory D Schroeder, Gursukhman S Sidhu, Alexander R Vaccaro
STUDY DESIGN: Systematic review. OBJECTIVE: To determine the incidence, pathogenesis, and clinical outcomes related to neurogenic fevers following traumatic spinal cord injury (SCI). METHODS: A systematic review of the literature was performed on thermodysregulation secondary to acute traumatic SCI in adult patients. A literature search was performed using PubMed (MEDLINE), Cochrane Central Register of Controlled Trials, and Scopus. Using strict inclusion and exclusion criteria, seven relevant articles were obtained...
September 2016: Global Spine Journal
https://www.readbyqxmd.com/read/27544377/safety-and-efficacy-of-vertebroplasty-for-acute-painful-osteoporotic-fractures-vapour-a-multicentre-randomised-double-blind-placebo-controlled-trial
#12
COMMENT
William Clark, Paul Bird, Peter Gonski, Terrence H Diamond, Peter Smerdely, H Patrick McNeil, Glen Schlaphoff, Carl Bryant, Elizabeth Barnes, Val Gebski
BACKGROUND: We hypothesised that vertebroplasty provides effective analgesia for patients with poorly controlled pain and osteoporotic spinal fractures of less than 6 weeks' duration. The effectiveness of vertebroplasty, using an adequate vertebral fill technique, in fractures of less than 6 weeks' duration has not been specifically assessed by previously published masked trials. METHODS: This was a multicentre, randomised, double-blind, placebo-controlled trial of vertebroplasty in four hospitals in Sydney, Australia...
October 1, 2016: Lancet
https://www.readbyqxmd.com/read/27477023/orthotic-management-of-instability-of-the-knee-related-to-neuromuscular-and-central-nervous-system-disorders-systematic-review-qualitative-study-survey-and-costing-analysis
#13
Joanne O'Connor, Dorothy McCaughan, Catriona McDaid, Alison Booth, Debra Fayter, Roccio Rodriguez-Lopez, Roy Bowers, Lisa Dyson, Cynthia P Iglesias, Simon Lalor, Rory J O'Connor, Margaret Phillips, Gita Ramdharry
BACKGROUND: Patients who have knee instability that is associated with neuromuscular disease (NMD) and central nervous system (CNS) conditions can be treated using orthoses, such as knee-ankle-foot orthoses (KAFOs). OBJECTIVES: To assess existing evidence on the effectiveness of orthoses; patient perspectives; types of orthotic devices prescribed in the UK NHS; and associated costs. METHODS: Qualitative study of views of orthoses users - a qualitative in-depth interview study was undertaken...
July 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27457478/comparison-of-two-psycho-educational-family-group-interventions-for-improving-psycho-social-outcomes-in-persons-with-spinal-cord-injury-and-their-caregivers-a-randomized-controlled-trial-of-multi-family-group-intervention-versus-an-active-education-control
#14
Dennis G Dyck, Douglas L Weeks, Sarah Gross, Crystal Lederhos Smith, Hilary A Lott, Aimee J Wallace, Sonya M Wood
BACKGROUND: Over 12,000 individuals suffer a spinal cord injury (SCI) annually in the United States, necessitating long-term, complex adjustments and responsibilities for patients and their caregivers. Despite growing evidence that family education and support improves the management of chronic conditions for care recipients as well as caregiver outcomes, few systematic efforts have been made to involve caregivers in psycho-educational interventions for SCI. As a result, a serious gap exists in accumulated knowledge regarding effective, family-based treatment strategies for improving outcomes for individuals with SCI and their caregivers...
July 26, 2016: BMC Psychology
https://www.readbyqxmd.com/read/27454662/is-there-any-analgesic-benefit-from-preoperative-vs-postoperative-administration-of-etoricoxib-in-total-knee-arthroplasty-under-spinal-anaesthesia-a-randomised-double-blind-placebo-controlled-trial
#15
Ana Maria Munteanu, Simona Cionac Florescu, Denisa Madalina Anastase, Cristian Ioan Stoica
BACKGROUND: Optimal postoperative analgesia is a challenge for the anaesthesiologist, with the ideal combination of methods, drugs, doses and timing of administration still the subject of research. The COX-2 inhibitors are a class of NSAIDs that may provide useful perioperative analgesia but the optimal timing of administration has not been elucidated. OBJECTIVE: We hypothesised that etoricoxib given 1 h before total knee arthroplasty under spinal anaesthesia will decrease the cumulative dose of intravenous and subcutaneous morphine required to maintain pain intensity of 3 or less on a 10-point numerical rating scale (NRS) during the first postoperative 48 h compared with the same dose of etoricoxib given after surgery...
November 2016: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/27448285/pregabalin-for-neuropathic-pain-why-benefits-could-be-expected-for-multiple-pain-conditions
#16
Setsuro Ogawa, Akio Arakawa, Kazuhiro Hayakawa, Tamotsu Yoshiyama
BACKGROUND AND OBJECTIVE: Limited research exists to support the extrapolation of the analgesic efficacy of pregabalin from one neuropathic pain condition to another. This retrospective analysis evaluated similarities in the efficacy of pregabalin for treating neuropathic pain associated with post-herpetic neuralgia (PHN), diabetic peripheral neuropathy (DPN), and spinal cord injury (SCI) in a Japanese population, as a basis for considering the extrapolation of these data to other neuropathic pain conditions...
November 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27299779/the-final-24-item-early-onset-scoliosis-questionnaires-eosq-24-validity-reliability-and-responsiveness
#17
Hiroko Matsumoto, Brendan Williams, Howard Y Park, Julie Y Yoshimachi, Benjamin D Roye, David P Roye, Behrooz A Akbarnia, John Emans, David Skaggs, John T Smith, Michael G Vitale
INTRODUCTION: The goal of early-onset scoliosis (EOS) treatment is to improve health-related quality of life (HRQoL) for patients and to reduce the burden on their parents or caregivers. The purpose of this study is to develop and finalize the 24-item Early-Onset Scoliosis Questionnaire (EOSQ-24), and examine the validity, reliability, and responsiveness of the EOSQ-24 in measuring patients' HRQoL, the burden on their caregivers, and the burden on their caregiver's finances. The study also established aged-matched normative values for the EOSQ-24...
June 13, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27280016/dose-response-of-spinal-manipulation-for-cervicogenic-headache-study-protocol-for-a-randomized-controlled-trial
#18
Linda Hanson, Mitchell Haas, Gert Bronfort, Darcy Vavrek, Craig Schulz, Brent Leininger, Roni Evans, Leslie Takaki, Moni Neradilek
BACKGROUND: Cervicogenic headache is a prevalent and costly pain condition commonly treated by chiropractors. There is evidence to support the effectiveness for spinal manipulation, but the dose of treatment required to achieve maximal relief remains unknown. The purpose of this paper is to describe the methodology for a randomized controlled trial evaluating the dose-response of spinal manipulation for chronic cervicogenic headache in an adult population. METHODS/DESIGN: This is a mixed-methods, two-site, prospective, parallel groups, observer-blind, randomized controlled trial conducted at university-affiliated research clinics in the Portland, OR and Minneapolis, MN areas...
2016: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/27270638/patient-induced-reaction-forces-and-moments-are-influenced-by-variations-in-spinal-manipulative-technique
#19
Kevin D'Angelo, John J Triano, Gregory N Kawchuk, Samuel J Howarth
STUDY DESIGN: An in vivo biomechanical study OBJECTIVE.: . The aim of the present study was to quantify and compare the reaction loads for two spinal manipulation therapy (SMT) procedures commonly used for low back pain using a biomechanical computer model. SUMMARY OF BACKGROUND DATA: Contemporary computer-driven rigid linked-segment models (LSMs) have made it feasible to analyze low back kinetics and kinematics during various activities including spinal manipulation therapy (SMT) procedures...
June 6, 2016: Spine
https://www.readbyqxmd.com/read/27137095/harmonization-of-databases-a-step-for-advancing-the-knowledge-about-spinal-cord-injury
#20
Susan Charlifue, Denise Tate, Fin Biering-Sorensen, Stephen Burns, Yuying Chen, Sophia Chun, Lyn B Jakeman, Robert G Kowalski, Vanessa K Noonan, Philip Ullrich
The objectives of this article are to (1) provide an overview of existing spinal cord injury (SCI) clinical research databases-their purposes, characteristics, and accessibility to users; and (2) present a vision for future collaborations required for cross-cutting research in SCI. This vision highlights the need for validated and relevant data for longitudinal clinical trials and observational and epidemiologic SCI-related studies. Three existing SCI clinical research databases/registries are reviewed and summarized with regard to current formats, collection methods, and uses, including major strengths and weaknesses...
October 2016: Archives of Physical Medicine and Rehabilitation
keyword
keyword
94625
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"