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spinal patients outcome research trial

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https://www.readbyqxmd.com/read/29625628/advanced-robotic-therapy-integrated-centers-artic-an-international-collaboration-facilitating-the-application-of-rehabilitation-technologies
#1
Hubertus J A van Hedel, Giacomo Severini, Alessandra Scarton, Anne O'Brien, Tamsin Reed, Deborah Gaebler-Spira, Tara Egan, Andreas Meyer-Heim, Judith Graser, Karen Chua, Daniel Zutter, Raoul Schweinfurther, J Carsten Möller, Liliana P Paredes, Alberto Esquenazi, Steffen Berweck, Sebastian Schroeder, Birgit Warken, Anne Chan, Amber Devers, Jakub Petioky, Nam-Jong Paik, Won-Seok Kim, Paolo Bonato, Michael Boninger
BACKGROUND: The application of rehabilitation robots has grown during the last decade. While meta-analyses have shown beneficial effects of robotic interventions for some patient groups, the evidence is less in others. We established the Advanced Robotic Therapy Integrated Centers (ARTIC) network with the goal of advancing the science and clinical practice of rehabilitation robotics. The investigators hope to exploit variations in practice to learn about current clinical application and outcomes...
April 6, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29624752/biomarkers-for-cognitive-impairment-in-lewy-body-disorders-status-and-relevance-for-clinical-trials
#2
REVIEW
Andrew Siderowf, Dag Aarsland, Brit Mollenhauer, Jennifer G Goldman, Bernard Ravina
Biomarkers have the potential to improve diagnosis and prognosis, and guide clinical treatment decisions. In research, biomarkers can be used for patient selection and as outcome measures in clinical trials. A range of biochemical and imaging biomarkers are relevant to patients with Lewy body disorders, including PD, PD dementia, and dementia with Lewy bodies. Dopaminergic imaging is used for differential diagnosis of parkinsonian disorders versus tremor disorders without dopamingeric deficits, and also to differentiate dementia with Lewy bodies from Alzheimer's disease...
April 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29596158/spinal-manipulation-and-exercise-for-low-back-pain-in-adolescents-a-randomized-trial
#3
Roni Evans, Mitchell Haas, Craig Schulz, Brent Leininger, Linda Hanson, Gert Bronfort
Low back pain (LBP) is common in adolescence but there is a paucity of high quality research to inform care. We conducted a multicenter randomized trial comparing 12 weeks of spinal manipulative therapy (SMT) combined with exercise therapy (ET) to ET alone.Participants were 185 adolescents aged 12-18 years with chronic LBP.The primary outcome was LBP severity at 12, 26, and 52 weeks. Secondary outcomes included disability, quality of life, medication use, patient and caregiver-rated improvement and satisfaction...
March 27, 2018: Pain
https://www.readbyqxmd.com/read/29476935/outcomes-following-minimally-invasive-lateral-transpsoas-interbody-fusion-for-degenerative-low-grade-lumbar-spondylolisthesis-a-systematic-review
#4
REVIEW
Anshit Goyal, Panagiotis Kerezoudis, Mohammed Ali Alvi, Sandy Goncalves, Mohamad Bydon
A variety of surgical approaches have been described to treat low grade lumbar degenerative spondylolisthesis (DS). Minimally invasive spinal fusion techniques were first introduced to minimize morbidities associated with invasive surgical treatments. Minimally invasive lateral transpsoas interbody fusion, also known as lateral lumbar interbody fusion (LLIF), is a relatively new method of lumbar arthrodesis that avoids various approach related complications compared to its posterior and anterior counterparts...
April 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29419692/comparison-of-surgical-or-nonsurgical-treatment-outcomes-in-patients-with-thoracolumbar-fracture-with-score-4-of-tlics-a-randomized-single-blind-and-single-central-clinical-trial
#5
Alireza Mohamadi, Ali Googanian, Ali Ahmadi, Alireza Kamali
BACKGROUND: Thoracolumbar fractures are among the most common types of damages caused to the spinal cord .Therefore, the aim of this study was the comparison of surgical or nonsurgical treatment outcomes in patients with thoracolumbar fracture with score 4 of the thoracolumbar injury classification and severity (TLICS) METHODS:: This study was clinical trial and double blind. Patients with thoracolumbar fracture with score 4 of TLICS entered at this research. We divided patients in 2 groups randomly (each group 25 patients) and then we followed patients for 1 year after start of treatment...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29419331/-icorg-05-03-prospective-randomized-non-inferiority-phase-iii-trial-comparing-two-radiation-schedules-in-malignant-spinal-cord-compression-not-proceeding-with-surgical-decompression-the-quality-of-life-analysis
#6
K A Lee, M Dunne, C Small, P J Kelly, O McArdle, J O'Sullivan, D Hacking, M Pomeroy, J Armstrong, M Moriarty, A Clayton-Lea, I Parker, C D Collins, P Thirion
BACKGROUND: The optimal primary external beam radiation therapy (EBRT) radiation schedule for malignant epidural spinal cord compression (MSCC) remains to be determined. The ICORG 05-03 trial assessed if a 10 Gy single fraction radiation schedule was not inferior to one with 20 Gray (Gy) in five daily fractions, in terms of functional motor outcome, for the treatment of MSCC in patients not proceeding with surgical decompression. This article reports on two of the secondary endpoints, Quality of life (QoL), assessed according to the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) version 3...
February 8, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29362950/aspirin-therapy-discontinuation-and-intraoperative-blood-loss-in-spinal-surgery-a-systematic-review
#7
Ann Cheng, Michael T C Poon, Andreas K Demetriades
The purpose of this study was to determine the effect of aspirin therapy discontinuation on intraoperative blood loss in spinal surgery. We searched Medline and Google Scholar 1946 to January 2017 inclusive for case-control studies, cohort studies, and controlled trials reporting intraoperative blood loss during spinal surgery in patients on pre-operative aspirin. Other outcome measures reported in the eligible studies were collected as secondary outcomes. Two reviewers independently screened and extracted data from each study...
January 23, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29357326/fusion-or-not-for-degenerative-lumbar-spinal-stenosis-a-meta-analysis-and-systematic-review
#8
Jieliang Shen, Shen Xu, Shenxi Xu, Sen Ye, Jie Hao
BACKGROUND: Degenerative lumbar spinal stenosis (DLSS) is the main cause for chronic low back pain in the elderly. When refractory to conservative treatment, symptomatic patients commonly undergo surgery. However, whether or not fusion is a relatively better surgical option still remains unclear. OBJECTIVE: The purpose of the present study was to systematically review the clinical outcomes of spinal decompression with or without spinal fusion for DLSS. STUDY DESIGN: A systematic review of the therapeutic effect for DLSS with or without fusion...
January 2018: Pain Physician
https://www.readbyqxmd.com/read/29353274/postoperative-immobilization-following-occipitocervical-fusion-in-the-pediatric-population-outcome-evaluation-and-review-of-literature
#9
Alexandre R Pingarilho, Paulo M Porto de Melo, Samer K Elbabaa
The scientific literature does not have a consensus about the role and method of postoperative immobilization after occipitocervical fusion in the pediatric population. The primary goal of this study is to review the medical literature and evaluate different immobilization methods and their impact on fusion, following the surgical management of craniocervical instability in children. It started with an extensive research of randomized controlled trials, series of cases and case reports, describing occipitocervical junction pathologies, clinical, epidemiological characteristics, and treatment...
January 20, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29343510/limited-radiographic-progression-and-sustained-reductions-in-mri-inflammation-in-patients-with-axial-spondyloarthritis-4-year-imaging-outcomes-from-the-rapid-axspa-phase-iii-randomised-trial
#10
Désirée van der Heijde, Xenofon Baraliakos, Kay-Geert A Hermann, Robert B M Landewé, Pedro M Machado, Walter P Maksymowych, Owen R Davies, Natasha de Peyrecave, Bengt Hoepken, Lars Bauer, Tommi Nurminen, Juergen Braun
OBJECTIVES: To report 4-year imaging outcomes in the RAPID-axSpA (NCT01087762) study of patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA), treated with certolizumab pegol (CZP). METHODS: This phase III, randomised trial was placebo-controlled and double-blind to week 24, dose-blind to week 48 and open-label to week 204. Patients fulfilling the Assessment of Spondyloarthritis International Society (ASAS) axSpA criteria with active disease were stratified (AS/nr-axSpA) according to the modified New York (mNY) criteria at randomisation...
January 17, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29260883/the-quality-of-life-of-children-under-chiropractic-care-using-promis-25-results-from-a-practice-based-research-network
#11
Joel Alcantara, Andrea E Lamont, Jeanne Ohm, Junjoe Alcantara
OBJECTIVES: To characterize pediatric chiropractic and assess pediatric quality of life (QoL). DESIGN: A prospective cohort. Setting/Locations: Individual offices within a practice-based research network located throughout the United States. SUBJECTS: A convenience sample of children (8-17 years) under chiropractic care and their parents. EXPOSURE: Chiropractic spinal adjustments and adjunctive therapies. OUTCOME MEASURES: Survey instrument measuring sociodemographic information and correlates from the clinical encounter along with the Patient Reported Outcomes Measurement Information System (PROMIS)-25 to measure QoL (i...
December 20, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29246847/individuals-with-lumbar-spinal-stenosis-seek-education-and-care-focused-on-self-management-results-of-focus-groups-among-participants-enrolled-in-a-randomized-controlled-trial
#12
Andrew D Lynch, Allyn M Bove, Carlo Ammendolia, Michael Schneider
BACKGROUND CONTEXT: The effectiveness of treatments for chronic, degenerative conditions of the lumbar spine can be influenced by patient perceptions and expectations regarding treatment. PURPOSE: The primary purpose of this study was to understand the factors that are important to individuals with lumbar spinal stenosis (LSS) regarding different nonsurgical treatments. These factors were considered within the context of each treatment received as a part of the parent randomized controlled trial (RCT)...
December 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29231159/facet-joint-injections-for-non-specific-low-back-pain-a-feasibility-rct
#13
Saowarat Snidvongs, Rod S Taylor, Alia Ahmad, Simon Thomson, Manohar Sharma, Angela Farr, Deborah Fitzsimmons, Stephanie Poulton, Vivek Mehta, Richard Langford
BACKGROUND: Pain of lumbar facet-joint origin is a common cause of low back pain in adults and may lead to chronic pain and disability, with associated health and socioeconomic implications. The socioeconomic burden includes an inability to return to work resulting in loss of productivity in addition to direct and indirect health-care utilisation costs. Lumbar facet-joints are paired synovial joints between the superior and inferior articular processes of consecutive lumbar vertebrae and between the fifth lumbar vertebra and the sacrum...
December 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29209926/a-randomized-trial-of-phenylephrine-infusion-versus-bolus-dosing-for-nausea-and-vomiting-during-cesarean-delivery-in-obese-women
#14
Ronald B George, Dolores M McKeen, Jennifer E Dominguez, Terrence K Allen, Patricia A Doyle, Ashraf S Habib
PURPOSE: Hypotension is common after spinal anesthesia for Cesarean delivery. It is associated with nausea, vomiting, and fetal acidosis. Previous research on phenylephrine excluded obese subjects. We compared the incidence of intraoperative nausea and vomiting (IONV) in obese patients who received a prophylactic phenylephrine infusion vs those who received bolus dosing for the treatment of spinal-induced hypotension. METHODS: In this multicentre, double-blinded randomized controlled trial, 160 obese women undergoing elective Cesarean delivery under spinal anesthesia were randomized to receive a prophylactic phenylephrine infusion initiated at 50 μg·min-1 (and titrated according to a predefined algorithm) or 100 μg phenylephrine boluses to treat hypotension...
March 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29051921/effectiveness-of-schroth-exercises-during-bracing-in-adolescent-idiopathic-scoliosis-results-from-a-preliminary-study-sosort-award-2017-winner
#15
Kenny Yat Hong Kwan, Aldous C S Cheng, Hui Yu Koh, Alice Y Y Chiu, Kenneth Man Chee Cheung
BACKGROUND: Bracing has been shown to decrease significantly the progression of high-risk curves to the threshold for surgery in patients with adolescent idiopathic scoliosis (AIS), but the treatment failure rate remains high. There is evidence to suggest that Schroth scoliosis-specific exercises can slow progression in mild scoliosis. The aim of this study was to evaluate the efficacy of Schroth exercises in AIS patients with high-risk curves during bracing. METHODS: A prospective, historical cohort-matched study was carried out...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/29017505/study-protocol-patient-reported-outcomes-for-bladder-management-strategies-in-spinal-cord-injury
#16
Darshan P Patel, Sara M Lenherr, John T Stoffel, Sean P Elliott, Blayne Welk, Angela P Presson, Amitabh Jha, Jeffrey Rosenbluth, Jeremy B Myers
BACKGROUND: The majority of spinal cord injury (SCI) patients have urinary issues, such as incontinence, retention, and frequency. These problems place a significant burden on patients' physical health and quality of life (QoL). There are a wide variety of bladder management strategies available to patients with no clear guidelines on appropriate selection. Inappropriate bladder management can cause hospitalizations and serious complications, such as urosepsis and renal failure. Patients believe that both independence and ability to carry out daily activities are just as important as physical health in selecting the right bladder-management strategy but little is known about patient's QoL with different bladder managements...
October 10, 2017: BMC Urology
https://www.readbyqxmd.com/read/28930903/effects-of-localized-cold-therapy-on-pain-in-postoperative-spinal-fusion-patients-a-randomized-control-trial
#17
RANDOMIZED CONTROLLED TRIAL
Patricia Quinlan, Jack Davis, Kara Fields, Pia Madamba, Lisa Colman, Daniela Tinca, Regina Cannon Drake
BACKGROUND: Cold therapy used in the sports medicine settings has been found to be effective in reducing postoperative pain; however, there are limited studies that examine the effect of cold therapy on postoperative pain in patients with posterior lumbar spinal fusion. PURPOSE: The purpose of this study was to determine the effects of cold on postoperative spine pain and add to the body of knowledge specific to practical application of cold therapy in the spine surgery setting...
September 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28877943/systematic-review-of-the-evidence-on-orthotic-devices-for-the-management-of-knee-instability-related-to-neuromuscular-and-central-nervous-system-disorders
#18
Catriona McDaid, Debra Fayter, Alison Booth, Joanne O'Connor, Rocio Rodriguez-Lopez, Dorothy McCaughan, Roy Bowers, Cynthia P Iglesias, Simon Lalor, Rory J O'Connor, Margaret Phillips, Gita Ramdharry
OBJECTIVES: To assess the effectiveness of orthotic devices for the management of instability of the knee in adults with a neuromuscular disorder or central nervous system disorder. DESIGN: A systematic review of primary studies. SETTING: Community. PARTICIPANTS: Adults with a neuromuscular disorder or central nervous system disorder and impaired walking ability due to instability of the knee. INTERVENTIONS: Orthoses with the clinical aim of controlling knee instability, for example, knee-ankle-foot orthoses, ankle-foot orthoses and knee orthoses or mixed design with no restrictions in design or material...
September 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28870836/patients-experience-with-non-surgical-treatment-for-lumbar-spinal-stenosis-a-qualitative-study
#19
Allyn M Bove, Andrew D Lynch, Carlo Ammendolia, Michael Schneider
BACKGROUND CONTEXT: Lumbar spinal stenosis (LSS) is a highly prevalent disease in older adults that causes significant limitations in walking and other daily activities. There is a lack of research into optimal non-surgical treatment approaches for LSS. PURPOSE: The purpose of this qualitative study is to assess the opinions of participants in a randomized clinical trial of nonsurgical LSS treatments regarding the interventions they received, factors contributing to adherence to the interventions, and methods of outcomes assessment...
September 21, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28816827/the-relationship-between-fear-avoidance-and-objective-biomechanical-measures-of-function-in-patients-with-adult-degenerative-scoliosis
#20
Ram Haddas, Isador H Lieberman, Andrew Block
STUDY DESIGN: A prospective cohort study. OBJECTIVE: The current study utilized quantitative gait analysis to examine the relationship of fear-avoidance beliefs to gait patterns in patients with adult degenerative scoliosis (ADS). SUMMARY OF BACKGROUND DATA: Among patients with chronic spine pain, fear-avoidance beliefs are predictive of behavioral deficiencies, poor work and surgery outcomes. The impact of such beliefs on patients with major spinal deformity has yet to be investigated...
August 14, 2017: Spine
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