keyword
MENU ▼
Read by QxMD icon Read
search

Kratom

keyword
https://www.readbyqxmd.com/read/29900296/metabolomics-data-of-mitragyna-speciosa-leaf-using-lc-esi-tof-ms
#1
Rubashiny Veeramohan, Kamalrul Azlan Azizan, Wan Mohd Aizat, Hoe-Han Goh, Sharif Mahsufi Mansor, Nur Sabrina Mohd Yusof, Syarul Nataqain Baharum, Chyan Leong Ng
Mitragyna speciosa is a psychoactive plant known as "ketum" in Malaysia and "kratom" in Thailand. This plant is distinctly known to produce two important alkaloids, namely mitragynine (MG) and 7-hydroxymitragynine (7-OH-MG) that can bind to opioid receptors [1]. MG was reported to exhibit antidepressant properties in animal studies [2]. These compounds were also proposed to have the potential to replace opioid analgesics with much lower risks of side effects [3]. To date, there are only over 40 metabolites identified in M...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29743100/cannabis-and-kratom-online-information-in-thailand-facebook-trends-2015-2016
#2
Kanittha Thaikla, Kanokporn Pinyopornpanish, Wichuda Jiraporncharoen, Chaisiri Angkurawaranon
BACKGROUND: Our study aims to evaluate the trends in online information about cannabis and kratom on Facebook in Thailand, where there is current discussion regarding legalizing these drugs. METHODS: Between April and November 2015, reviewers searched for cannabis and kratom Facebook pages in the Thai language via the common search engines. Content analysis was performed and the contents of each page were categorized by the tone of the post (positive, negative or neutral)...
May 9, 2018: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/29718282/suspected-driving-under-the-influence-case-involving-mitragynine
#3
Trista H Wright
Mitragynine is a novel psychoactive substance (NPS) that has emerged as a designer opioid being distributed on the street. Mitragynine, also known as kratom, has dose-dependent pharmacological effects and possesses both stimulant-like and sedative effects due to dual-binding of α-adrenergic and μ-opioid receptors. This herbal remedy readily available online has caused adverse effects including tachycardia, agitation, tremors, hallucination and death; however, this is the first reported suspected driving under the influence case involving mitragynine...
April 27, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29678221/determination-of-alkaloids-in-mitragyna-speciosa-kratom-raw-materials-and-dietary-supplements-by-hplc-uv-single-laboratory-validation-first-action-2017-14
#4
Elizabeth M Mudge, Paula N Brown
The AOAC Expert Review Panel (ERP) approved a method for the quantitation of alkaloids in Mitragynaspeciosa for consideration as First Action Official Method SM status. The previously published method summarized a single-laboratory validation of two alkaloids, mitragynine and 7-hydroxymitragynine, in raw materials and finished products. The methods performance was compared with the AOAC Standard Method Performance Requirement 2015.008. With repeatability precision (RSDr ) ranging from 0.51 to 0.95% and recoveries from 93...
April 20, 2018: Journal of AOAC International
https://www.readbyqxmd.com/read/29652682/kratom-an-emerging-drug-of-abuse-a-case-report-of-overdose-and-management-of-withdrawal
#5
Jack Diep, David Tian Chin, Somdatta Gupta, Faraz Syed, Ming Xiong, Jianguo Cheng
Kratom is an herb indigenous to Southeast Asia with psychoactive opioid compounds, often used as a treatment for chronic pain or opiate withdrawal symptoms. It is legally and readily available via Internet sales and has been identified as an emerging drug of abuse in the United States. Kratom use has been associated with psychosis, seizures, and even death. At lower doses, kratom acts as a stimulant, while at higher doses, it produces analgesia and euphoria. Here, we describe the successful management of kratom overdose and withdrawal in a young man with negative toxicology screens...
April 15, 2018: A&A practice
https://www.readbyqxmd.com/read/29626673/assessment-of-gonadotropins-and-testosterone-hormone-levels-in-regular-mitragyna-speciosa-korth-users
#6
Darshan Singh, Vikneswaran Murugaiyah, Shahrul Bariyah Sahul Hamid, Vicknasingam Kasinather, Michelle Su Ann Chan, Eric Tatt Wei Ho, Oliver Grundmann, Nelson Jeng Yeou Chear, Sharif Mahsufi Mansor
ETHNOPHARMACOLOGICAL RELEVANCE: Mitragyna speciosa (Korth.) also known as kratom, is a native medicinal plant of Southeast Asia with opioid-like effects. Kratom tea/juice have been traditionally used as a folk remedy and for controlling opiate withdrawal in Malaysia. Long-term opioid use is associated with depletion in testosterone levels. AIM OF THE STUDY: Since kratom is reported to deform sperm morphology and reduce sperm motility, we aimed to clinically investigate the testosterone levels following long-term kratom tea/juice use in regular kratom users...
July 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29568783/kratom-an-emerging-drug-of-abuse-raises-prolactin-and-causes-secondary-hypogonadism-case-report
#7
Lauren LaBryer, Rohan Sharma, Kaustubh Suresh Chaudhari, Mitali Talsania, Robert Hal Scofield
Background. Kratom is a drug derived from the leaves of the tree Mitragyna speciose , which is native to southern Thailand. The route of administration is oral. Kratom has become increasingly available in the United States. The active ingredients in the drug bind the opioid mu-receptor; therefore, kratom has similar physiological effects as mu-opioids. Elevated prolactin is a common medical condition frequently caused by a variety drugs, including opioids. Case Report. A 42-year-old man presented with poor energy and low libido...
January 2018: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29558272/severity-of-pain-and-sleep-problems-during-kratom-mitragyna-speciosa-korth-cessation-among-regular-kratom-users
#8
Darshan Singh, Suresh Narayanan, Balasingam K Vicknasingam, Walter C Prozialeck, Surash Ramanathan, Hadzliana Zainal, Sabariah Noor Harun
Kratom (Mitragyna speciosa Korth.) is traditionally used in Southeast Asia for its medicinal value and psychoactive properties. Nonetheless, cessation from regular kratom use is reported to cause unpleasant dose-dependent withdrawal symptoms. This study aims to evaluate the severity of pain and sleep problems following the cessation of kratom tea/juice consumption among regular kratom users. A total of 170 regular users were recruited through snowball sampling for this cross-sectional study. The Brief Pain Inventory (BPI) and Pittsburgh Sleep Quality Index (PSQI) scales were administered to assess the severity of pain and sleep problems...
March 20, 2018: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/29520812/nature-s-first-atypical-opioids-kratom-and-mitragynines
#9
R B Raffa, J V Pergolizzi, R Taylor, M H Ossipov
WHAT IS KNOWN AND OBJECTIVE: Advances in pain research have led to an understanding that many pains are driven by more than one underlying (patho)physiologic cause (ie, they are "multimechanistic") and that better pain relief is obtained with fewer adverse effects when an analgesic is correspondingly multimechanistic. At least two of the more-modern analgesics combine opioid and non-opioid mechanisms, and have become known as "atypical opioids." Less well known is that just as Nature evolved opioids, it also evolved atypical opioids, presaging modern drug discovery efforts...
June 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29511414/histologic-characterization-of-kratom-use-associated-liver-injury
#10
Michael Riverso, Michael Chang, Consuelo Soldevila-Pico, Jinping Lai, Xiuli Liu
Kratom is an herbal product derived from the leaves of Southeast Asian Mitragyna speciosa trees. It has traditionally been used by indigenous people to relieve fatigue and manage pain, diarrhea, or opioid withdrawal. The use of kratom has become more commonplace in the United States for similar purposes. Only rare reports of kratom liver toxicity exist in the literature but without histologic characterization. Herein, we report one case of kratom use-associated liver toxicity in a 38-year-old patient. The patient complained of dark colored urine and light colored stools after using kratom...
February 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29488268/trends-in-the-use-of-illicit-substances-in-thailand-results-from-national-household-surveys
#11
Chaisiri Angkurawaranon, Wichuda Jiraporncharoen, Surinporn Likhitsathian, Kanittha Thaikla, Manop Kanato, Usaneya Perngparn, Sawitri Assanangkornchai, Apinun Aramrattana
INTRODUCTION AND AIMS: Thailand borders some of the world's largest methamphetamine and opioid producing countries and trafficking routes. Thailand's 'War on Drugs' campaign was launched in 2003. This study reports trends in illicit substance use in Thailand over the period 2001-2011. DESIGN AND METHODS: National Household surveys on illicit drug use were conducted in 2001, 2003, 2007, 2008 and 2011. A stratified multi-stage cluster random sampling technique was implemented for each survey...
February 27, 2018: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29459087/identification-of-five-mitragyna-alkaloids-in-urine-using-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#12
Stephanie Basiliere, Kelsie Bryand, Sarah Kerrigan
Mitragyna speciosa (Kratom) is a psychoactive plant that has recently emerged as a recreational drug. Mitragyna alkaloids are not within the scope of traditional forensic toxicology screening methods, which may contribute to under-reporting. Solid phase extraction (SPE) and liquid chromatography-quadrupole/time of flight mass spectrometry (LC-Q/TOF-MS) were used to identify five alkaloids in urine. Target analytes included the two known psychoactive compounds, mitragynine and 7-hydroxymitragynine, in addition to speciociliatine, speciogynine, and paynantheine...
March 30, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29456604/death-from-kratom-toxicity-and-the-possible-role-of-intralipid
#13
Geeta Aggarwal, Edward Robertson, James McKinlay, Edward Walter
We present the case of a 26-year-old man who was brought into our emergency department in cardiorespiratory arrest, having taken Kratom 24 h previously. Despite multi-organ support, he deteriorated and died from cardiorespiratory failure and hypoxic brain damage 12 h later. Lipid emulsion was given, with significant temporary improvement in the cardiorespiratory failure. Kratom is derived from Mitragyna speciosa, a tropical deciduous and evergreen tree in the coffee family, and is native to Southeast Asia, and its leaves are used as a legal high in some parts of the world...
February 2018: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/29449242/novel-case-of-maternal-and-neonatal-kratom-dependence-and-withdrawal
#14
Lindsay Mackay, Ronald Abrahams
No abstract text is available yet for this article.
February 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29287305/development-of-an-immunochromatographic-strip-incorporating-anti-mitragynine-monoclonal-antibody-conjugated-to-colloidal-gold-for-kratom-alkaloids-detection
#15
Supattra Limsuwanchote, Waraporn Putalun, Hiroyuki Tanaka, Satoshi Morimoto, Niwat Keawpradub, Juraithip Wungsintaweekul
A lateral flow-based immunochromatographic strip was developed for the rapid detection of mitragynine (MG), a dominant alkaloid found in the leaves of kratom. Monoclonal antibody (mAb) against MG (anti-MG mAb) was conjugated to colloidal gold and used as a recognition probe. MG-ovalbumin conjugate (MG-OVA) and goat anti-mouse IgG were immobilized on the strip to produce a test zone and control zone, respectively. Based on the principle of a competitive assay, MG in a test sample competed with MG-OVA resident in the test zone to bind with colloidal gold-anti-MG mAb, resulting in an inverse relation of color intensity at the test zone and MG amount...
December 29, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29273821/the-abuse-potential-of-kratom-according-the-8-factors-of-the-controlled-substances-act-implications-for-regulation-and-research
#16
REVIEW
Jack E Henningfield, Reginald V Fant, Daniel W Wang
RATIONALE: Consideration by the US Drug Enforcement Administration and Food and Drug Administration of placing kratom into Schedule I of the Controlled Substances Act (CSA) requires its evaluation of abuse potential in the context of public health. OBJECTIVE: The objective of the study is to provide a review of kratom abuse potential and its evaluation according to the 8 factors of the CSA. RESULTS: Kratom leaves and extracts have been used for centuries in Southeast Asia and elsewhere to manage pain and other disorders and, by mid-twentieth century, to manage opioid withdrawal...
February 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29248691/kratom-use-and-mental-health-a-systematic-review
#17
REVIEW
Marc T Swogger, Zach Walsh
BACKGROUND: Kratom (Mitragyna speciosa) is a psychoactive plant native to Southeastern Asia that is receiving increased international attention as a potential therapeutic agent. While much of the limited scientific research on kratom is focused on its analgesic potential, kratom use also has important risks and benefits in the domain of mental health. METHODS: We conducted a comprehensive systematic review of all studies on kratom use and mental health published between January 1960 and July 2017...
February 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29248450/evaluating-the-hematological-and-clinical-chemistry-parameters-of-kratom-mitragyna-speciosa-users-in-malaysia
#18
Darshan Singh, Christian P Müller, Vikneswaran Murugaiyah, Shahrul Bariyah Sahul Hamid, Balasingam K Vicknasingam, Bonnie Avery, Nelson Jeng Yeou Chear, Sharif Mahsufi Mansor
ETHNOPHARMACOLOGICAL RELEVANCE: Kratom (Mitragyna speciosa Korth.) from the Rubiaceae family is an indigenous tropical medicinal tree of Southeast Asia. Kratom leaves have been used for decades in Malaysia and Thailand in traditional context for its perceived vast medicinal value, and as a mild stimulant among manual labourers. Kratom consumption has been reported to cause side-effects in kratom users. AIM OF THE STUDY: To evaluate kratom's effects towards hematological and clinical-chemistry parameters among regular kratom users in Malaysia...
March 25, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29190268/synthetic-cannabinoid-and-mitragynine-exposure-of-law-enforcement-agents-during-the-raid-of-an-illegal-laboratory-nevada-2014
#19
Loren Tapp, Jessica G Ramsey, Anita Wen, Roy Gerona
Synthetic cannabinoids (SCs), commonly known by the street name "Spice," are designer drugs of abuse that mimic the psychoactive effects of marijuana. Intentional SC use has resulted in multiple toxicities (1,2), but little is known about occupational SC exposure. After a federal agency's law enforcement personnel in Nevada reported irritability and feeling "high" after raiding illegal SC laboratories and processing seized SCs, a request for a health hazard evaluation was made by the agency to CDC's National Institute for Occupational Safety and Health (NIOSH) in 2014 to evaluate agents' occupational SC exposures...
December 1, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29077662/kratom-an-emerging-drug-of-abuse-a-case-report-of-overdose-and-management-of-withdrawal
#20
Jack Diep, David Tian Chin, Somdatta Gupta, Faraz Syed, Ming Xiong, Jianguo Cheng
Kratom is an herb indigenous to Southeast Asia with psychoactive opioid compounds, often used as a treatment for chronic pain or opiate withdrawal symptoms. It is legally and readily available via Internet sales and has been identified as an emerging drug of abuse in the United States. Kratom use has been associated with psychosis, seizures, and even death. At lower doses, kratom acts as a stimulant, while at higher doses, it produces analgesia and euphoria. Here, we describe the successful management of kratom overdose and withdrawal in a young man with negative toxicology screens...
October 26, 2017: A & A Case Reports
keyword
keyword
9462
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"