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https://www.readbyqxmd.com/read/28634435/the-clinical-uses-of-electrocochleography
#1
REVIEW
William P Gibson
The clinical uses of electrocochleography are reviewed with some technical notes on the apparatus needed to get clear recordings under different conditions. Electrocochleography can be used to estimate auditory thresholds in difficult to test children and a golf club electrode is described. The same electrode can be used to obtain electrical auditory brainstem responses (EABR). Diagnostic testing in the clinic can be performed with a transtympanic needle electrode, and a suitable disposable monopolar electrode is described...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28622352/volunteer-trials-of-a-novel-improvised-dry-decontamination-protocol-for-use-during-mass-casualty-incidents-as-part-of-the-uk-s-initial-operational-response-ior
#2
Richard Amlôt, Holly Carter, Lorna Riddle, Joanne Larner, Robert P Chilcott
Previous studies have demonstrated that rapid evacuation, disrobing and emergency decontamination can enhance the ability of emergency services and acute hospitals to effectively manage chemically-contaminated casualties. The purpose of this human volunteer study was to further optimise such an "Initial Operational Response" by (1) identifying an appropriate method for performing improvised skin decontamination and (2) providing guidance for use by first responders and casualties. The study was performed using two readily available, absorbent materials (paper towels and incontinence pads)...
2017: PloS One
https://www.readbyqxmd.com/read/28616241/passive-leg-raising-test-with-minimally-invasive-monitoring-the-way-forward-for-guiding-septic-shock-resuscitation
#3
Patrick M Honore, Herbert D Spapen
BACKGROUND: Swift and adequate fluid loading is a cornerstone of septic shock therapy. Yet, careful assessment of volume responsiveness and volume amount during the resuscitation process is a prerequisite. Both overzealous initial fluid administration and late fluid overload are harmful and may be associated with increased mortality. MAIN BODY: Static (i.e., central venous or pulmonary artery occlusion) pressure readings are erroneous for monitoring fluid resuscitation and should be abandoned...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28605040/acute-hepatic-porphyrias-recommendations-for-evaluation-and-long-term-management
#4
Manisha Balwani, Bruce Wang, Karl E Anderson, Joseph R Bloomer, D Montgomery Bissell, Herbert L Bonkovsky, John D Phillips, Robert J Desnick
The acute hepatic porphyrias (AHPs) are a group of four inherited disorders, each resulting from the deficient activity of a specific enzyme in the heme biosynthetic pathway. They present clinically with acute neurovisceral symptoms which may be sporadic or recurrent, and which, when severe, can be life-threatening. The diagnosis is often missed or delayed as the clinical features resemble other more common medical conditions. There are four major subgroups: symptomatic patients with sporadic or recurrent acute attacks, asymptomatic high porphyrin precursor excretors, and asymptomatic latent patients without symptoms or porphyrin precursor elevations...
June 12, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28597285/impaired-laparoscopic-performance-of-novice-surgeons-due-to-phone-call-distraction-a-single-centre-prospective-study
#5
Cui Yang, Julia Heinze, Jens Helmert, Juergen Weitz, Christoph Reissfelder, Soeren Torge Mees
BACKGROUND: Distractions such as phone calls during laparoscopic surgery play an important role in many operating rooms. The aim of this single-centre, prospective study was to assess if laparoscopic performance is impaired by intraoperative phone calls in novice surgeons. METHODS: From October 2015 to June 2016, 30 novice surgeons (medical students) underwent a laparoscopic surgery training curriculum including two validated tasks (peg transfer, precision cutting) until achieving a defined level of proficiency...
June 8, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28595973/crash-probability-estimation-via-quantifying-driver-hazard-perception
#6
Yang Li, Yang Zheng, Jianqiang Wang, Kenji Kodaka, Keqiang Li
Crash probability estimation is an important method to predict the potential reduction of crash probability contributed by forward collision avoidance technologies (FCATs). In this study, we propose a practical approach to estimate crash probability, which combines a field operational test and numerical simulations of a typical rear-end crash model. To consider driver hazard perception characteristics, we define a novel hazard perception measure, called as driver risk response time, by considering both time-to-collision (TTC) and driver braking response to impending collision risk in a near-crash scenario...
June 5, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28587776/pharmacological-characterization-of-a-novel-potent-selective-and-orally-active-phosphodiesterase-2a-inhibitor-pdm-631
#7
Shunsuke Maehara, Keita Arakawa, Kotaro Hoshida, Hiroshi Nagasue, Noboru Chida, Kazunari Nakao, Shoji Furusako
Recently, we identified a novel phosphodiesterase 2A (PDE2A) inhibitor, PDM-631 ((S)-3-cyclopropyl-6-methyl-1-(1-(4-(trifluoromethoxy)phenyl)propan-2-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one). PDM-631 showed potent inhibitory activities for human and rat PDE2A with IC50 values of 1.5 and 4.2nM, respectively and more than 2000-fold selectivity against other phosphodiesterases. In rat studies, PDM-631 showed oral bioavailability and good brain penetration, and increased the cGMP levels in the cortex...
June 3, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28582548/butterflies-do-not-alter-conspecific-avoidance-in-response-to-variation-in-density
#8
Sarah Jaumann, Emilie C Snell-Rood
High conspecific densities are associated with increased levels of intraspecific competition and a variety of negative effects on performance. However, changes in life history strategy could compensate for some of these effects. For instance, females in crowded conditions often have fewer total offspring, but they may invest more in each one. Such investment could include the production of larger offspring, more time spent engaging in parental care, or more choosy decisions about where offspring are placed...
June 3, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28551714/cue-avoidance-training-and-inhibitory-control-training-for-the-reduction-of-alcohol-consumption-a-comparison-of-effectiveness-and-investigation-of-their-mechanisms-of-action
#9
Lisa C G Di Lemma, Matt Field
RATIONALE: Both cue avoidance training (CAT) and inhibitory control training (ICT) reduce alcohol consumption in the laboratory. However, these interventions have never been directly compared and their mechanisms of action are poorly understood. OBJECTIVES: We compared the effects of both types of training on alcohol consumption and investigated if they led to theoretically predicted changes in alcohol avoidance (CAT) or alcohol inhibition (ICT) associations and changes in evaluation of alcohol cues...
May 27, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28550792/social-stress-contagion-in-rats-behavioural-autonomic-and-neuroendocrine-correlates
#10
Luca Carnevali, Nicola Montano, Rosario Statello, Gino Coudé, Federica Vacondio, Silvia Rivara, Pier Francesco Ferrari, Andrea Sgoifo
The negative emotional consequences associated with life stress exposure in an individual can affect the emotional state of social partners. In this study, we describe an experimental rat model of social stress contagion and its effects on social behaviour and cardiac autonomic and neuroendocrine functions. Adult male Wistar rats were pair-housed and one animal (designated as "demonstrator" (DEM)) was submitted to either social defeat stress (STR) by an aggressive male Wild-type rat in a separate room or just exposed to an unfamiliar empty cage (control condition, CTR), once a day for 4 consecutive days...
May 20, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28540103/correlation-between-kind-of-delivery-and-posttraumatic-stress-disorder
#11
Z Mahmoodi, M Dolatian, Z Shaban, J Shams, H Alavi-Majd, A Mirabzadeh
BACKGROUND: Posttraumatic stress disorder (PTSD) is a very common mental condition and a unique anxiety disorder. AIM: The present study tried to examine the correlation between kind of delivery and PTSD. SUBJECTS AND METHODS: This prospective study evaluated 240 Iranian female residents of Tehran, Iran, during the third trimester of their pregnancy and 6-8 weeks after labor. Data were collected using the customized screening form, the Symptom Checklist-90, PTSD Symptom Scale (PSS), and Social Support Questionnaire...
November 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28529445/regression-models-on-riemannian-symmetric-spaces
#12
Emil Cornea, Hongtu Zhu, Peter Kim, Joseph G Ibrahim
The aim of this paper is to develop a general regression framework for the analysis of manifold-valued response in a Riemannian symmetric space (RSS) and its association with multiple covariates of interest, such as age or gender, in Euclidean space. Such RSS-valued data arises frequently in medical imaging, surface modeling, and computer vision, among many others. We develop an intrinsic regression model solely based on an intrinsic conditional moment assumption, avoiding specifying any parametric distribution in RSS...
March 2017: Journal of the Royal Statistical Society. Series B, Statistical Methodology
https://www.readbyqxmd.com/read/28527279/-cases-of-acute-pesticide-poisoning-in-colonia-puerto-pirap%C3%A3-itap%C3%A3%C2%BAa-paraguay-february-2014
#13
María Esther Pedrozo, Sandra Ocampos, Rosa Galeano, Andrea Ojeda, Agueda Cabello, Dalva De Assis
In Paraguay, pesticides are the causative agent in 13.7% of poisonings, especially organophosphorus compounds. Such poisoning produces the inhibition of acetylcholinesterase generating three possible clinical conditions: acute poisoning, intermediate syndrome or late neurotoxicity. We present 15 cases of acute poisoning, ten women and five men from a rural community between 5 and 67 years of age, whose symptoms began after using water contaminated by pesticides from the community network. The most common symptoms were nausea and vomiting, followed by abdominal pain, headache, fever, itching, red eyes and sweating...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28521372/synthesis-and-characterization-of-new-azecine-derivatives-as-potential-neuroleptics
#14
Stephanie Zergiebel, Christian Fleck, Hans-Dieter Arndt, Christoph Enzensperger, Andreas Seeling
Dibenzo- and benzindolo-azecines represent a class of potential neuroleptics. To characterize the effectiveness at the dopamine and 5-HT2A-receptor representative structures were synthesized and tested by radio ligand binding studies, in vivo and in vitro studies.Neuroleptic potency and the risk of side effects of the prodrug 7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-yl isobutyrate, an ester derivative of the most promising azecine 7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-ol (LE404), was tested in vivo concerning conditioned avoidance response inhibition, locomotor activity and triggering of catalepsy vs...
May 18, 2017: Drug Research
https://www.readbyqxmd.com/read/28521241/cognitive-avoidance-and-aversive-cues-related-to-tobacco-in-male-smokers
#15
Ji Sun Hong, Sun Mi Kim, Hye Yeon Jung, Kyoung Doo Kang, Kyung Joon Min, Doug Hyun Han
BACKGROUND: Treatment using aversive conditioning has been suggested for smoking cessation. The efficacy of this method is thought to be associated with cognitive avoidance. We compare differences in avoidance traits and patterns of associated brain activation in response to cues that induce cravings versus aversion between smokers and non-smokers. METHODS: Fifteen smokers and fifteen non-smokers completed cue reactivity tasks while undergoing functional magnetic resonance imaging (fMRI) to examine brain responses to craving-inducing cues (Cr) and aversion-inducing cues (Av)...
May 11, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28512726/cutaneous-reflex-modulation-during-obstacle-avoidance-under-conditions-of-normal-and-degraded-visual-input
#16
Daniel S Marigold, Andrew J Chang, Kim Lajoie
The nervous system integrates visual input regarding obstacles with limb-based sensory feedback to allow an individual to safely negotiate the environment. This latter source can include cutaneous information from the foot, particularly in the event that limb trajectory is not sufficient and there is an unintended collision with the object. However, it is not clear the extent to which cutaneous reflexes are modified based on visual input. In this study, we first determined if phase-dependent modulation of these reflexes is present when stepping over an obstacle during overground walking...
May 16, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28500512/molecular-adaptations-to-social-defeat-stress-and-induced-depression-in-mice
#17
Natalya Bondar, Leonid Bryzgalov, Nikita Ershov, Fedor Gusev, Vasiliy Reshetnikov, Damira Avgustinovich, Mikhail Tenditnik, Evgeny Rogaev, Tatiana Merkulova
Chronic stress is a risk factor for major depression. Social defeat stress is a well-validated murine model of depression. However, little is known about the gene activity dynamics during the development of a depression-like state. We analyzed the effects of social defeat stress of varying duration (10 and 30 days) on the behavioral patterns and prefrontal-cortex transcriptome of C57BL/6 mice. The 10-day exposure to social defeat stress resulted in a high level of social avoidance with no signs of depression-associated behavior...
May 12, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28492659/ensemble-clustering-of-phosphoproteomic-data-identifies-differences-in-protein-interactions-and-cell-cell-junction-integrity-of-her2-overexpressing-cells
#18
Katherine E Schaberg, Venktesh S Shirure, Elizabeth A Worley, Steven C George, Kristen M Naegle
Overexpression of HER2, a receptor tyrosine kinase of the ERBB family, in breast cancer is related to increased cancer progression and aggressiveness. A breast epithelial cell model with the single perturbation of HER2 overexpression is capable of replicating the increased aggressiveness of HER2 overexpressing cancers. In previous work, Wolf-Yadlin and colleagues (Wolf-Yadlin et al., Mol. Syst. Biol., 2006, 2) measured the proximal tyrosine phosphorylation dynamics of the parental and HER2 overexpressing cells (24H) in response to EGF...
May 11, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28487141/a-randomized-cross-over-study-of-the-effects-of-macronutrient-composition-and-meal-frequency-on-glp-1-ghrelin-and-energy-expenditure-in-humans
#19
Simon Ingves, Nathalie Vilhelmsson, Edvin Ström, Mats Fredrikson, Hans Guldbrand, Fredrik H Nystrom
OBJECTIVE: Little is known about human postprandial increase of energy expenditure and satiety-associated hormones in relation to both meal frequency and macronutrient composition. DESIGN: Randomized cross-over study with four conditions for each participant. METHODS: Seven men and seven women (mean age 23±1.5years) were randomly assigned to the order of intake of a 750kcal drink with the same protein content while having either 20 energy-percent (E%) or 55 E% from carbohydrates and the remaining energy from fat...
May 6, 2017: Peptides
https://www.readbyqxmd.com/read/28474772/modelling-individual-response-time-effects-between-and-within-experimental-speed-conditions-a-glmm-approach-for-speeded-tests
#20
Frank Goldhammer, Merle A Steinwascher, Ulf Kroehne, Johannes Naumann
Completing test items under multiple speed conditions avoids the performance measure being confounded with individual differences in the speed-accuracy compromise, and offers insights into the response process, that is, how response time relates to the probability of a correct response. This relation is traditionally represented by two conceptually different functions: the speed-accuracy trade-off function (SATF) across conditions relating the condition average response time to the condition average of accuracy, and the conditional accuracy function (CAF) within a condition describing accuracy conditional on response time...
May 2017: British Journal of Mathematical and Statistical Psychology
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