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https://www.readbyqxmd.com/read/29928309/diagnosis-and-outcomes-of-transcatheter-aortic-valve-implantation-in-bicuspid-aortic-valve-stenosis
#1
REVIEW
Sung-Han Yoon, Yoshio Maeno, Hiroyuki Kawamori, Masaki Miyasaka, Takahiro Nomura, Tomoki Ochiai, Shadi Nemanpour, Matthias Raschpichler, Rahul Sharma, Tarun Chakravarty, Raj Makkar
Bicuspid aortic valve is the most common congenital cardiac malformation. Aortic valve replacement is often required in older patients but the surgical risk is often extremely high. As Transcatheter aortic valve implantation (TAVI) is an established therapy for intermediate and high surgical risk patients with symptomatic severe aortic valve stenosis (AS). Advances in technology and knowledge have led to TAVI being used for other pathologies and populations such as bicuspid AS. Recently, the diagnosis and classification of bicuspid aortic valve based on multidetector computed tomography (MDCT) assessment has been proposed, which may have an impact of outcomes after TAVI...
May 2018: Interventional Cardiology
https://www.readbyqxmd.com/read/29928215/an-unusual-coexistence-of-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-with-endometrioid-type-endometrial-cancer-in-a-58-year-old-woman-a-case-study-with-literature-review
#2
Dominik Dłuski, Dorota Lewkowicz, Bożena Leszczyńska-Gorzelak, Bogdan Obrzut, Tomasz Rechberger, Andrzej Semczuk
Introduction: The coexistence of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with different gynecologic neoplasms is a rare phenomenon. Here, we report a case of simultaneously developed CLL/SLL with endometrioid-type uterine cancer. Case Report: A 58-year-old woman was admitted to the 2nd Department of Gynecology, Lublin Medical University, Lublin, Poland, in June 2017, where the uterine cancer was diagnosed. After the surgery, pathological examination revealed a uterine moderately differentiated adenocarcinoma of endometrioid subtype (subtype I according to Bokhman) deeply infiltrating the myometrium as well as the uterine cervix...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29928209/endophytic-type-endometrial-cancer-with-adenomyosis-successfully-diagnosed-with-hysteroscopic-endometrial-biopsy-using-an-8-3-mm-operative-resectoscope-a-case-report
#3
Michiko Honda, Akira Tsuchiya, Wataru Isono, Mikiko Takahashi, Akihisa Fujimoto, Masashi Kawamoto, Osamu Nishii
In order to diagnose endometrial cancer preoperatively, outpatient endometrial biopsy with a curette is frequently performed owing to its convenience. However, in some cases, gynecologists fail to diagnose endometrial cancer via outpatient endometrial biopsy because of the cancer's distribution in the uterus and its consistency. A 57-year-old Japanese woman (gravida 4 para 4) presented with a 6-month history of light but intermittent postmenopausal vaginal bleeding. A malignant uterine tumor was strongly suspected after imaging using ultrasound examination and magnetic resonance imaging; however, a precise pathological diagnosis was not achieved despite multiple outpatient endometrial biopsies with the aid of office hysteroscopy...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29924789/-endoprosthetic-repair-of-the-aorta-for-an-infrarenal-aneurysm-combined-with-occlusion-of-one-of-the-iliac-arteries
#4
I V Popova, A A Karpenko, P V Ignatenko, V B Starodubtsev
Described herein is a clinical case report regarding successful endovascular treatment of a patient presenting with an abdominal aortic aneurysm combined with occlusion of one of the iliac arteries. Cases concerning elimination of such pathology appear to be reported only sporadically in the available literature. The patient underwent reconstructive repair in two stages. The first stage comprised recanalization with stenting of the occluded iliac artery on the right and implantation of the Zenith stent graft...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924787/-staged-treatment-of-a-multilevel-lesion-of-brachiocephalic-arteries-in-combination-with-coronary-and-valvular-pathology-of-the-heart
#5
M A Cherniavskiĭ, A A Gusev, D V Chernova, I V Iarkov, M L Gordeev
Prevention of neurological complications in cardiosurgical and reconstructive vascular surgery is one of the priority tasks of preserving ability to work and decreasing invalidization of patients in the postoperative period. Presented in the article is a clinical case report regarding multiple-stage treatment of a female patient with a combined aortic defect, coronary pathology, and a multilevel bilateral lesion of the brachiocephalic arteries. The first stage consisted in performing a hybrid operation, i. e...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29922726/endovascular-treatment-of-thoracic-aortic-pseudoaneurysm-through-a-subclavian-approach-in-patient-with-aortoiliac-occlusive-disease-a-case-report
#6
Ezequiel Paredes-Mariñas, Carme Llort-Pont, Francisca Castro-Bolance, Vicente Riambau-Alonso
Introduction: Thoracic endovascular aortic repair (TEVAR) has become the preferred option for treatment of thoracic aortic pathology, but lack of vascular access options is a common contraindication to TEVAR. Case report: The authors report a case of a 67 year old male patient with multiple revascularisation procedures: bilateral axillofemoral bypass and thoracic aortofemoral bypass, both occluded. An anastomotic pseudoaneurysm of the thoracic aorta developed and detected on computed tomography angiography (CTA)...
2018: EJVES Short Reports
https://www.readbyqxmd.com/read/29911345/evaluation-of-new-generation-loop-recorders-placed-during-surgical-ablation-for-atrial-fibrillation
#7
Zachary DeBoard, John R Doty
BACKGROUND: Current postsurgical atrial fibrillation (AF) ablation guidelines encourage serial rhythm evaluation; however, traditional Holter monitoring may be cumbersome for patients and yield limited data. An implantable loop recorder (LR) may provide increased data on the incidence of postablation arrhythmias. We sought to evaluate the use of a new generation LR implanted during surgical AF ablation. METHODS: A retrospective analysis was performed on adult patients undergoing surgical AF ablation...
June 17, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29910055/arterioventricular-interaction-after-coarctation-repair
#8
Elles J Dijkema, Martijn G Slieker, Tim Leiner, Heynric B Grotenhuis
BACKGROUND: Hypertension is common in patients with coarctation of the aorta (CoA), even after successful repair. Increased aortic stiffness has been implicated in the pathology of CoA-associated hypertension. This study aimed to investigate aortic vascular function and its relationship with hypertension in well-repaired CoA-patients at long-term follow-up. Furthermore, we assessed the additive effect of hypertension to adverse arterioventricular coupling associated with increased aortic stiffness...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29907330/blood-flow-patterns-and-pressure-loss-in-the-ascending-aorta-a-comparative-study-on-physiological-and-aneurysmal-conditions
#9
Utku Gülan, Christelle Calen, Firat Duru, Markus Holzner
An aortic aneurysm is defined as a balloon-shaped bulging of all three histologic components of the aortic vessel walls (intima, media and adventitia). This dilation results from vessel weakening owing to remodeling, i.e. due to cystic degeneration of the Tunica media (Marfan), progression of atherosclerosis or presence of a bicuspid aortic valve. The growth rate of the aortic diameter varies from patient to patient and may progress until the aneurysm ultimately ruptures. The role of hemodynamics, i.e. blood flow patterns, and shear stresses that are supposed to intensify during aneurysm growth are not yet fully understood, but thought to play a key role in the enlargement process...
June 8, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29905015/investigation-of-raphe-function-in-the-bicuspid-aortic-valve-and-its-influence-on-clinical-criteria-a-patient-specific-finite-element-study
#10
Jérémy Dallard, Michel R Labrosse, Benjamin Sohmer, Carsten J Beller, Munir Boodhwani
The aortic valve is normally composed of three cusps. In one common lesion, two cusps are fused together. The conjoined area of the fused cusps is termed raphe. Occurring in 1-2% of the population, the bicuspid aortic valve (BAV) is the most common congenital cardiac malformation. The majority of BAV patients eventually require surgery. There is a lack in the literature regarding modeling of the raphe (geometry and material properties), its role and its influence on BAV function. The present study aims to propose improvements on these aspects...
June 14, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29903350/acute-limited-intimal-tears-of-the-thoracic-aorta
#11
Anne S Chin, Martin J Willemink, Aya Kino, Virginia Hinostroza, Anna M Sailer, Michael P Fischbein, R Scott Mitchell, Gerald J Berry, D Craig Miller, Dominik Fleischmann
BACKGROUND: Limited intimal tears (LITs) of the aorta (Class 3 dissection variant) are the least common form of aortic pathology in patients presenting with acute aortic syndrome (AAS). LITs are difficult to detect on imaging and may be underappreciated. OBJECTIVES: This study sought to describe the frequency, pathology, treatment, and outcome of LITs compared with other AAS, and to demonstrate that LITs can be detected pre-operatively by contemporary imaging. METHODS: The authors retrospectively reviewed 497 patients admitted for 513 AAS events at a single academic aortic center between 2003 and 2012...
June 19, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29898143/predictors-of-outcomes-after-correction-of-acute-type-a-aortic-dissection-under-moderate-hypothermic-circulatory-arrest-and-antegrade-cerebral-perfusion
#12
George Samanidis, Charalampos Katselis, Constantinos Contrafouris, Georgios Georgiopoulos, Ioannis Kriaras, Theofani Antoniou, Konstantinos Perreas
INTRODUCTION: Hypothermic circulatory arrest is widely used for correction of acute type A aortic dissection pathology. We present our experience of 45 consecutive patients operated in our unit with bilateral antegrade cerebral perfusion and moderate hypothermic circulatory arrest. METHODS: Between January 2011 and April 2015, 45 consecutive patients were admitted for acute type A aortic dissection and operated emergently under moderate hypothermic circulatory arrest and bilateral antegrade cerebral perfusion...
March 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29897100/controlled-hypotension-versus-normotensive-resuscitation-strategy-for-people-with-ruptured-abdominal-aortic-aneurysm
#13
REVIEW
Daniel H Moreno, Daniel G Cacione, Jose Cc Baptista-Silva
BACKGROUND: An abdominal aortic aneurysm (AAA) is the pathological enlargement of the aorta and can develop in both men and women. Progressive aneurysm enlargement can lead to rupture. The rupture of an AAA is frequently fatal and accounts for the death from haemorrhagic shock of at least 45 people per 100,000 population. The outcome of people with ruptured AAA varies among countries and healthcare systems, with mortality ranging from 53% to 90%. Definitive treatment for ruptured AAA includes open surgery or endovascular repair...
June 13, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29896234/inhibition-of-prostaglandin-e2-protects-abdominal-aortic-aneurysm-from-expansion-through-regulating-mir-29b-mediated-fibrotic-ecm-expression
#14
Zonglin Han, Tangshan Zhang, Yuxiang He, Gang Li, Gang Li, Xing Jin
The risk of rupture, the most feared clinical consequence of abdominal aortic aneurysm, increases with the enlargement of aorta. MicroRNA-29b (miR-29b) has emerged as a key modulator of extracellular matrix (ECM) homeostasis and thereby is proposed to play a crucial role in vascular remodeling. However, agents that alter miR-29b expression are relatively inefficient in the aorta, likely due to inferior uptake. Herein we found that miR-29b was upregulated in aortic smooth muscle cells upon prostaglandin E2 (PGE2 ) stimulation whereas indomethacin treatment downregulated miR-29b expression...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896044/open-replacement-of-the-thoracoabdominal-aorta-short-and-long-term-outcomes-at-a-single-institution
#15
Davide Carino, Young Erben, Mohammad A Zafar, Mrinal Singh, Adam J Brownstein, Maryann Tranquilli, John Rizzo, Bulat A Ziganshin, John A Elefteriades
Background  Despite much progress in the surgical and endovascular treatment of thoracoabdominal aortic diseases (TAADs), there is no consensus regarding the optimal approach to minimize operative mortality and end-organ dysfunction. We report our experience in the past 16 years treating TAAD by open surgery. Methods  A retrospective review of all TAAD patients who underwent an open repair since January 2000 was performed. The primary endpoints included early morbidity and mortality, and the secondary endpoints were overall death and rate of aortic reintervention...
June 2018: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29896040/endovascular-treatment-of-various-aortic-pathologies-review-of-the-latest-data-and-technologies
#16
REVIEW
Koji Maeda, Takao Ohki, Yuji Kanaoka
The technologies and innovations applicable to endovascular treatment for complex aortic pathologies have progressed rapidly over the last two decades. Although the initial outcomes of an endovascular aortic repair have been excellent, as long-term data became available, complications including endoleaks, endograft migration, and endograft infection have become apparent and are of concern. Previously, the indication for endovascular therapy was restricted to descending thoracic aortic aneurysms and abdominal aortic aneurysms...
June 2018: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29894584/cd11b-interstitial-macrophages-are-required-for-ischemia-induced-lung-angiogenesis
#17
Aigul Moldobaeva, Qiong Zhong, Lindsey Eldridge, Elizabeth M Wagner
The importance of myeloid cells in promoting neovascularization has been shown in a number of pathological settings in several organs. However, the specific role of macrophages in promoting systemic angiogenesis during pulmonary ischemia is not fully determined. Our past work suggested that cells of monocytic lineage contributed to systemic angiogenesis in the lung since clodronate-induced depletion of all macrophages resulted in attenuated neovascularization. Our current goals were to define the population of macrophages important for systemic vessel growth into the lung after the onset of pulmonary ischemia in mice...
June 2018: Physiological Reports
https://www.readbyqxmd.com/read/29892230/loss-of-akap1-exacerbates-pressure-overload-induced-cardiac-hypertrophy-and-heart-failure
#18
Gabriele G Schiattarella, Nicola Boccella, Roberta Paolillo, Fabio Cattaneo, Valentina Trimarco, Anna Franzone, Stefania D'Apice, Giuseppe Giugliano, Laura Rinaldi, Domenica Borzacchiello, Alessandra Gentile, Assunta Lombardi, Antonio Feliciello, Giovanni Esposito, Cinzia Perrino
Left ventricular hypertrophy (LVH) is a major contributor to the development of heart failure (HF). Alterations in cyclic adenosine monophosphate (cAMP)-dependent signaling pathways participate in cardiomyocyte hypertrophy and mitochondrial dysfunction occurring in LVH and HF. cAMP signals are received and integrated by a family of cAMP-dependent protein kinase A (PKA) anchor proteins (AKAPs), tethering PKA to discrete cellular locations. AKAPs encoded by the Akap1 gene (mitoAKAPs) promote PKA mitochondrial targeting, regulating mitochondrial structure and function, reactive oxygen species production, and cell survival...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29890445/evidence-of-aortic-dissection-and-marfan-syndrome-in-a-mummy-from-the-capuchin-catacombs-of-palermo-sicily
#19
Stephanie Panzer, Randall C Thompson, Klaus Hergan, Albert R Zink, Dario Piombino-Mascali
The authors report on the assessment of an anthropogenic mummy of a young man from the Capuchin Catacombs of Palermo, Sicily, tentatively dated from the mid- to late 19th century AD. The mummy was investigated by full-body CT examination. CT images clearly showed aortic dissection classified as Stanford-A. Due to the relation of aortic dissection to inherited connective tissue diseases in young people, such as Marfan syndrome, conspicuous and pathological findings possibly indicating the presence of underlying Marfan syndrome were assessed...
June 8, 2018: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29887702/the-futility-of-systematic-lymphadenectomy-in-early-stage-low-grade-endometrial-cancer
#20
Nidhi Nayyar, Prerna Lakhwani, Ashish Goel, Pankaj Kr Pande, Kapil Kumar
Lymphadenectomy is considered an integral part of comprehensive surgical staging of endometrial cancer but debate on the value of lymphadenectomy continues in early-stage endometrial cancer. The aim of our study was to determine the number of node positive patients in clinically early-stage low-grade (G1-G2) endometrioid endometrial cancer. We retro-prospectively analyzed the medical records of 155 women with endometrial pathology coming to the BLK cancer center between January 2015 and December 2017 and studied 60 patients of FIGO grade 1-2 endometrioid endometrial cancer confined to the uterus to determine the nodal positivity...
June 2018: Indian Journal of Surgical Oncology
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