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https://www.readbyqxmd.com/read/29212224/hadc5-deacetylates-mkl1-to-dampen-tnf-%C3%AE-induced-pro-inflammatory-gene-transcription-in-macrophages
#1
Zilong Li, Hao Qin, Jianfei Li, Liming Yu, Yuyu Yang, Yong Xu
Macrophage-dependent inflammatory response on the one hand functions as a key line of defense in host immunity but on the other hand underlies the pathogenesis of a host of human pathologies when aberrantly activated. Our previous investigations have led to the identification of megakaryocytic leukemia 1 (MKL1) as a key co-factor of NF-κB/p65 participating in TNF-α induced pro-inflammatory transcription in macrophages. How post-translational modifications contribute to the modulation of MKL1 activity remains an underexplored subject matter...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29199045/the-mechanism-of-myocardial-hypertrophy-regulated-by-the-interaction-between-mhrt-and-myocardin
#2
Ying Luo, Yao Xu, Chen Liang, Weibing Xing, Tongcun Zhang
As a strong transactivator of promoters containing CarG boxes, myocardin was critical for the cardiac muscle program and necessary for normal cardiogenesis. So it probably represents a viable therapeutic biomarker in the setting of cardiac hypertrophy and failure. In recent years, the studies of regulation of cardiac hypertrophy via myocardin are so common, and the molecular mechanism is becoming more and more clear. Here, we have revealed a kind of interaction between mhrt and myocardin shown as a feedback regulatory mechanism in the regulation of cardiac hypertrophy...
December 1, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/29176673/phosphoproteomics-of-camp-signaling-of-bordetella-adenylate-cyclase-toxin-in-mouse-dendritic-cells
#3
Jakub Novák, Ivo Fabrik, Irena Linhartová, Marek Link, Ondřej Černý, Jiří Stulík, Peter Šebo
The adenylate cyclase toxin (CyaA) of the whooping cough agent Bordetella pertussis subverts immune functions of host myeloid cells expressing the αMβ2 integrin (CD11b/CD18, CR3 or Mac-1). CyaA delivers into cytosol of cells an extremely catalytically active adenylyl cyclase enzyme, which disrupts the innate and adaptive immune functions of phagocytes through unregulated production of the key signaling molecule cAMP. We have used phosphoproteomics to analyze cAMP signaling of CyaA in murine bone marrow-derived dendritic cells...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29164959/palmatine-attenuates-isoproterenol-induced-pathological-hypertrophy-via-selectively-inhibiting-hdac2-in-rats
#4
Yonggang Yuan, Wanzhong Peng, Yongxing Liu, Zesheng Xu
This study aimed to exploit the potential therapeutic value of palmatine in treatment of cardiac hypertrophy and the underlying molecular mechanism. Rat hypertrophy model was established by intraperitoneal isoproterenol (ISO) injection. The hypertrophy was evaluated with cardiac hypertrophic parameters, hemodynamic parameters, lipid profile, and non-specific cardiac markers. The animals were intraperitoneally administrated with either palmatine or vehicle. The relative expressions of ANP, BNP, HDAC2, HDAC5, KLF4, and INPP5F transcripts were determined by real-time polymerase chain reaction (PCR)...
November 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29138868/hdac-inhibitor-lmk%C3%A2-235-promotes-the-odontoblast-differentiation-of-dental-pulp-cells
#5
Zhao Liu, Ting Chen, Qianqian Han, Ming Chen, Jie You, Fuchun Fang, Ling Peng, Buling Wu
The role of dental pulp cells (DPCs) in hard dental tissue regeneration had received increasing attention because DPCs can differentiate into odontoblasts and other tissue‑specific cells. In recent years, epigenetic modifications had been identified to serve an important role in cell differentiation, and histone deacetylase (HDAC) inhibitors have been widely studied by many researchers. However, the effects of HDAC4 and HDAC5 on the differentiation of DPCs and the precise molecular mechanisms remain unclear...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29109977/prior-alcohol-use-enhances-vulnerability-to-compulsive-cocaine-self-administration-by-promoting-degradation-of-hdac4-and-hdac5
#6
Edmund A Griffin, Philippe A Melas, Royce Zhou, Yang Li, Peter Mercado, Kimberly A Kempadoo, Stacy Stephenson, Luca Colnaghi, Kathleen Taylor, Mei-Chen Hu, Eric R Kandel, Denise B Kandel
Addiction to cocaine is commonly preceded by experiences with legal or decriminalized drugs, such as alcohol, nicotine, and marijuana. The biological mechanisms by which these gateway drugs contribute to cocaine addiction are only beginning to be understood. We report that in the rat, prior alcohol consumption results in enhanced addiction-like behavior to cocaine, including continued cocaine use despite aversive consequences. Conversely, prior cocaine use has no effect on alcohol preference. Long-term, but not short-term, alcohol consumption promotes proteasome-mediated degradation of the nuclear histone deacetylases HDAC4 and HDAC5 in the nucleus accumbens, a brain region critical for reward-based memory...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29074220/development-of-a-multiplexed-tumor-associated-autoantibody-based-blood-test-for-the-detection-of-colorectal-cancer
#7
Chung-Wei Fan, Yung-Bin Kuo, Geng-Pin Lin, Si-Min Chen, Shih-Hsien Chang, Bo-An Li, Err-Cheng Chan
BACKGROUND: Colorectal cancer (CRC) is one of the most common malignancies worldwide, and early diagnosis is vital to improving prognoses. We explored the diagnostic potential of a multiplex autoantibody panel as a biomarker for the detection of CRC by ELISA. METHODS: In total, 192 serum samples (92 CRC and 100 matched controls) were tested against a panel of 12 tumor-associated antigens (TAAs): RPH3AL, RPL36, SLP2, p53, survivin, ANAXA4, SEC61B, CCCAP, NYCO16, NMDAR, PLSCR1, and HDAC5...
October 23, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29065178/intravital-imaging-of-osteocytes-in-mouse-calvaria-using-third-harmonic-generation-microscopy
#8
Danielle Tokarz, Richard Cisek, Marc N Wein, Raphaël Turcotte, Christa Haase, Shu-Chi A Yeh, Srinidhi Bharadwaj, Anthony P Raphael, Hari Paudel, Clemens Alt, Tzu-Ming Liu, Henry M Kronenberg, Charles P Lin
Osteocytes are the most abundant cell in the bone, and have multiple functions including mechanosensing and regulation of bone remodeling activities. Since osteocytes are embedded in the bone matrix, their inaccessibility makes in vivo studies problematic. Therefore, a non-invasive technique with high spatial resolution is desired. The purpose of this study is to investigate the use of third harmonic generation (THG) microscopy as a noninvasive technique for high-resolution imaging of the lacunar-canalicular network (LCN) in live mice...
2017: PloS One
https://www.readbyqxmd.com/read/28957674/a-molecular-code-for-imprinting-drug-cue-associations
#9
Adrian M Gomez, Michael R Bruchas
Previous studies suggest that nuclear histone deacetylase HDAC5 has a dynamic relationship with drug-induced behavioral neuroadaptations. The new work by Taniguchi et al. (2017) suggests that targets of nuclear HDAC5 mediate the behavioral effects of rewarding drugs via regulation of cocaine-associated stimuli.
September 27, 2017: Neuron
https://www.readbyqxmd.com/read/28957664/hdac5-and-its-target-gene-npas4-function-in-the-nucleus-accumbens-to-regulate-cocaine-conditioned-behaviors
#10
Makoto Taniguchi, Maria B Carreira, Yonatan A Cooper, Ana-Clara Bobadilla, Jasper A Heinsbroek, Nobuya Koike, Erin B Larson, Evan A Balmuth, Brandon W Hughes, Rachel D Penrod, Jaswinder Kumar, Laura N Smith, Daniel Guzman, Joseph S Takahashi, Tae-Kyung Kim, Peter W Kalivas, David W Self, Yingxi Lin, Christopher W Cowan
Individuals suffering from substance-use disorders develop strong associations between the drug's rewarding effects and environmental cues, creating powerful, enduring triggers for relapse. We found that dephosphorylated, nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model. We also discovered that HDAC5 associates with an activity-sensitive enhancer of the Npas4 gene and negatively regulates NPAS4 expression...
September 27, 2017: Neuron
https://www.readbyqxmd.com/read/28744146/rna-sequencing-identifies-gene-expression-profile-changes-associated-with-%C3%AE-estradiol-treatment-in-u2os-osteosarcoma-cells
#11
Bin Chen, Zude Liu, Jidong Zhang, Hantao Wang, Bo Yu
This study was conducted to identify gene expression profile changes associated with β-estradiol (E2) treatment in U2OS osteosarcoma cells by high-throughput RNA sequencing (RNA-seq). Two U2OS cell samples treated with E2 (15 μmol/L) and two untreated control U2OS cell samples were subjected to RNA-seq. Differentially expressed genes (DEGs) between the groups were identified, and main biological process enrichment was performed using gene ontology (GO) analysis. A protein-protein interaction (PPI) network was constructed using Cytoscape based on the Human Protein Reference Database...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28688716/exercise-induced-glut4-transcription-via-inactivation-of-hdac4-5-in-mouse-skeletal-muscle-in-an-ampk%C3%AE-2-dependent-manner
#12
Yanmei Niu, Tianyi Wang, Sujuan Liu, Hairui Yuan, Huige Li, Li Fu
Abnormal glucose metabolism induces various metabolic disorders such as insulin resistance and type 2 diabetes. Regular exercise improved glucose uptake and enhanced glucose oxidation by increasing GLUT4 transcription in skeletal muscle. However, the regulatory mechanisms of GLUT4 transcription in response to exercise are poorly understood. AMPK is a sensor of exercise and upstream kinase of class II HDACs that act as transcriptional repressors. We used 6-week treadmill exercise or one single-bout exercise wild type or AMPKα2(-/-) C57BL/6J mice to explore how HDACs regulate GLUT4 transcription and the underlying molecular mechanisms mediated by AMPK in the physiologic process of exercise...
July 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28681592/oleanolic-acid-promotes-neuronal-differentiation-and-histone-deacetylase-5-phosphorylation-in-rat-hippocampal-neurons
#13
Hye-Ryeong Jo, Sung Eun Wang, Yong-Seok Kim, Chang Ho Lee, Hyeon Son
Oleanolic acid (OA) has neurotrophic effects on neurons, although its use as a neurological drug requires further research. In the present study, we investigated the effects of OA and OA derivatives on the neuronal differentiation of rat hippocampal neural progenitor cells. In addition, we investigated whether the class II histone deacetylase (HDAC) 5 mediates the gene expression induced by OA. We found that OA and OA derivatives induced the formation of neurite spines and the expression of synapse-related molecules...
July 31, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28635037/novel-role-and-regulation-of-hdac4-in-cocaine-related-behaviors
#14
Rachel D Penrod, Maria B Carreira, Makoto Taniguchi, Jaswinder Kumar, Stephanie A Maddox, Christopher W Cowan
Epigenetic mechanisms have been proposed to contribute to persistent aspects of addiction-related behaviors. One family of epigenetic molecules that may regulate maladaptive behavioral changes produced by cocaine use are the histone deacetylases (HDACs)-key regulators of chromatin and gene expression. In particular, the class IIa HDACs (HDAC4, HDAC5, HDAC7 and HDAC9) respond to changes in neuronal activity by modulating their distribution between the nucleus and cytoplasm-a process controlled in large part by changes in phosphorylation of conserved residues...
June 21, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28577999/ketamine-induces-brain-derived-neurotrophic-factor-expression-via-phosphorylation-of-histone-deacetylase-5-in-rats
#15
Miyeon Choi, Seung Hoon Lee, Min Hyeop Park, Yong-Seok Kim, Hyeon Son
Ketamine shows promise as a therapeutic agent for the treatment of depression. The increased expression of brain-derived neurotrophic factor (BDNF) has been associated with the antidepressant-like effects of ketamine, but the mechanism of BDNF induction is not well understood. In the current study, we demonstrate that the treatment of rats with ketamine results in the dose-dependent rapid upregulation of Bdnf promoter IV activity and expression of Bdnf exon IV mRNAs in rat hippocampal neurons. Transfection of histone deacetylase 5 (HDAC5) into rat hippocampal neurons similarly induces Bdnf mRNA expression in response to ketamine, whereas transfection of a HDAC5 phosphorylation-defective mutant (Ser259 and Ser498 replaced by Ala259 and Ala498), results in the suppression of ketamine-mediated BDNF promoter IV transcriptional activity...
August 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28567090/expression-of-class-i-and-class-ii-a-b-histone-deacetylase-is-dysregulated-in-hypertensive-animal-models
#16
Hae Jin Kee, Gwi Ran Kim, Ming Quan Lin, Sin Young Choi, Yuhee Ryu, Li Jin, Zhe Hao Piao, Myung Ho Jeong
BACKGROUND AND OBJECTIVES: Dysregulation of histone deacetylase expression and enzymatic activity is associated with a number of diseases. It has been reported that protein levels of histone deacetylase (HDAC)1 and HDAC5 increase during human pulmonary hypertension, and that the enzymatic activity of HDAC6 is induced in a chronic hypertensive animal model. This study investigated the protein expression profiles of class I and II a/b HDACs in three systemic hypertension models. SUBJECTS AND METHODS: We used three different hypertensive animal models: (i) Wistar-Kyoto rats (n=8) and spontaneously hypertensive rats (SHR; n=8), (ii) mice infused with saline or angiotensin II to induce hypertension, via osmotic mini-pump for 2 weeks, and (iii) mice that were allowed to drink L-N(G)-nitro-L-arginine methyl ester (L-NAME) to induce hypertension...
May 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28526090/reduced-hdac2-in-skeletal-muscle-of-copd-patients
#17
Masako To, Elisabeth B Swallow, Kenich Akashi, Kosuke Haruki, S Amanda Natanek, Michael I Polkey, Kazuhiro Ito, Peter J Barnes
BACKGROUND: Skeletal muscle weakness in chronic obstructive pulmonary disease (COPD) is an important predictor of poor prognosis, but the molecular mechanisms of muscle weakness in COPD have not been fully elucidated. The aim of this study was to investigate the role of histone deacetylases(HDAC) in skeletal muscle weakness in COPD. METHODS AND RESULTS: Twelve COPD patients, 8 smokers without COPD (SM) and 4 healthy non-smokers (NS) were recruited to the study. HDAC2 protein expression in quadriceps muscle biopsies of COPD patients (HDAC2/β-actin: 0...
May 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28505206/effects-of-%C3%AE-tat1-and-hdac5-on-axonal-regeneration-in-adult-neurons
#18
Shen Lin, Noelle A Sterling, Ian P Junker, Courtney T Helm, George M Smith
The role of posttranslational modifications in axonal injury and regeneration has been widely studied but there has been little consensus over the mechanism by which each modification affects adult axonal growth. Acetylation is known to play an important role in a variety of neuronal functions and its homeostasis is controlled by two enzyme families: the Histone Deacetylases (HDACs) and Histone Acetyl Transferases (HATs). Recent studies show that HDAC5 deacetylates microtubules in the axonal cytoplasm as part of an injury-induced regeneration response, but little is known about how acetylation of microtubules plays a role...
2017: PloS One
https://www.readbyqxmd.com/read/28496307/developing-selective-histone-deacetylases-hdacs-inhibitors-through-ebselen-and-analogs
#19
Yuren Wang, Jason Wallach, Stephanie Duane, Yuan Wang, Jianghong Wu, Jeffrey Wang, Adeboye Adejare, Haiching Ma
Histone deacetylases (HDACs) are key regulators of gene expression in cells and have been investigated as important therapeutic targets for cancer and other diseases. Different subtypes of HDACs appear to play disparate roles in the cells and are associated with specific diseases. Therefore, substantial effort has been made to develop subtype-selective HDAC inhibitors. In an effort to discover existing scaffolds with HDAC inhibitory activity, we screened a drug library approved by the US Food and Drug Administration and a National Institutes of Health Clinical Collection compound library in HDAC enzymatic assays...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28475869/glucose-sensing-by-skeletal-myocytes-couples-nutrient-signaling-to-systemic-homeostasis
#20
Zhuo-Xian Meng, Jianke Gong, Zhimin Chen, Jingxia Sun, Yuanyuan Xiao, Lin Wang, Yaqiang Li, Jianfeng Liu, X Z Shawn Xu, Jiandie D Lin
Skeletal muscle is a major site of postprandial glucose disposal. Inadequate insulin action in skeletal myocytes contributes to hyperglycemia in diabetes. Although glucose is known to stimulate insulin secretion by β cells, whether it directly engages nutrient signaling pathways in skeletal muscle to maintain systemic glucose homeostasis remains largely unexplored. Here we identified the Baf60c-Deptor-AKT pathway as a target of muscle glucose sensing that augments insulin action in skeletal myocytes. Genetic activation of this pathway improved postprandial glucose disposal in mice, whereas its muscle-specific ablation impaired insulin action and led to postprandial glucose intolerance...
May 4, 2017: Molecular Cell
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