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boswellia, cognitive

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https://www.readbyqxmd.com/read/26984336/co-administration-of-3-acetyl-11-keto-beta-boswellic-acid-potentiates-the-protective-effect-of-celecoxib-in-lipopolysaccharide-induced-cognitive-impairment-in-mice-possible-implication-of-anti-inflammatory-and-antiglutamatergic-pathways
#1
Aya Shoukry Sayed, Nesrine Salah El Dine El Sayed
Neuro-inflammation is known to initiate the underlying pathogenesis of several neurodegenerative disorders which may progress to cognitive, behavioral, and functional impairment. Boswellia serrata is a well-known powerful anti-inflammatory agent used to treat several inflammatory diseases. The aim of the current study is to investigate the effect of the combination therapy of 3-acetyl-11-keto-β-boswellic acid (AKBA), a 5-lipoxygenase (5-LOX) inhibitor and celecoxib, and a selective cyclooxygenase-2 (COX-2) inhibitor as dual enzyme inhibitors compared to monotherapies with celecoxib and AKBA...
May 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/25657807/the-effects-of-aqueous-extract-of-boswellia-serrata-on-hippocampal-region-ca1-and-learning-deficit-in-kindled-rats
#2
C Jalili, M R Salahshoor, A Pourmotabbed, S Moradi, Sh Roshankhah, A Shabanizadeh Darehdori, M Motaghi
Temporal lobe epilepsy (TLE) is a disorder of the central nervous system in which hippocampus is mostly involved and causes memory impairment. Kindling is a model of inducing epilepsy which is created through pentylenetetrazol (PTZ) administration. This study examines the role of the aqueous extract of Boswellia on the learning and development of brain (formation of dendritic branches and axons) of the PTZ-induced kindled rats. The study is conducted on sixty-four male rats divided into 8 groups. Kindling seizures are induced by three injections of 25 mg/kg of PTZ every 15 min...
September 2014: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/25422734/effect-of-boswellia-papyrifera-on-cognitive-impairment-in-multiple-sclerosis
#3
Behnaz Sedighi, Abbas Pardakhty, Hoda Kamali, Kaveh Shafiee, Bahar Naz Hasani
BACKGROUND: Cognitive impairment is one of the most crucial disorders among multiple sclerosis (MS) patients. Since MS is an inflammatory disease and Boswellia papyrifera has anti-inflammatory effects, the influence of B. papyrifera on cognitive impairment in MS patients has been investigated in the present study. METHODS: In this clinical trial, 80 MS patients who referred to the clinic of Shafa Hospital, Kerman, Iran were selected. Having completed a written consent form, patients with relapsing remitting MS, with no occurrence of a new attack throughout 1 month before the study, with no pregnancy or breastfeeding entered the study...
July 4, 2014: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/24932387/the-therapeutic-effect-of-the-aqueous-extract-of-boswellia-serrata-on-the-learning-deficit-in-kindled-rats
#4
Cyrus Jalili, Mohammad Reza Salahshoor, Sima Moradi, Ali Pourmotabbed, Moslem Motaghi
BACKGROUND: It has been reported that epilepsy is a disorder of the central nervous system that causes memory impairment. This study examines the role of the aqueous extract of Boswellia on the learning disability of the pentylenetetrazol (PTZ)-induced kindled rats. METHODS: In this experimental study, 64 male rats were used. Kindling seizures were induced by three injections of 25 mg/kg of PTZ every 15 min. Control animals received normal saline instead. To evaluate the therapeutic effect of Boswellia extract on the PTZ-induced cognitive deficits, the aqueous extract (0, 0...
May 2014: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/24088189/the-effect-of-boswellia-serrata-on-neurorecovery-following-diffuse-axonal-injury
#5
RANDOMIZED CONTROLLED TRIAL
Payam Moein, Salman Abbasi Fard, Ali Asnaashari, Hajar Baratian, Majid Barekatain, Naser Tavakoli, Houshang Moein
OBJECTIVES: This pilot trial was conducted to establish whether Boswellia Serrata (BS), a traditional herbal medicine, could improve the outcome of patients who have diffuse axonal injury (DAI). METHODS: In total, 38 patients with pure DAI were enrolled in this 12-week, double-blind, randomized, cross-over study. The patients were randomly assigned to receive either placebo (group A, n = 20) or BS capsules (group B, n = 18) for 6 weeks and then switched to the other intervention for another 6 weeks...
2013: Brain Injury: [BI]
https://www.readbyqxmd.com/read/21287538/boswellia-serrata-acts-on-cerebral-edema-in-patients-irradiated-for-brain-tumors-a-prospective-randomized-placebo-controlled-double-blind-pilot-trial
#6
RANDOMIZED CONTROLLED TRIAL
Simon Kirste, Markus Treier, Sabine Jolie Wehrle, Gerhild Becker, Mona Abdel-Tawab, Kathleen Gerbeth, Martin Johannes Hug, Beate Lubrich, Anca-Ligia Grosu, Felix Momm
BACKGROUND: Patients irradiated for brain tumors often suffer from cerebral edema and are usually treated with dexamethasone, which has various side effects. To investigate the activity of Boswellia serrata (BS) in radiotherapy-related edema, we conducted a prospective, randomized, placebo-controlled, double-blind, pilot trial. METHODS: Forty-four patients with primary or secondary malignant cerebral tumors were randomly assigned to radiotherapy plus either BS 4200 mg/day or placebo...
August 15, 2011: Cancer
https://www.readbyqxmd.com/read/18414499/incensole-acetate-a-novel-neuroprotective-agent-isolated-from-boswellia-carterii
#7
Arieh Moussaieff, Na'ama A Shein, Jeanna Tsenter, Savvas Grigoriadis, Constantina Simeonidou, Alexander G Alexandrovich, Victoria Trembovler, Yinon Ben-Neriah, Michael L Schmitz, Bernd L Fiebich, Eduardo Munoz, Raphael Mechoulam, Esther Shohami
Boswellia resin has been used as a major anti-inflammatory agent and for the healing of wounds for centuries. Incensole acetate (IA), isolated from this resin, was shown to inhibit the activation of nuclear factor-kappaB, a key transcription factor in the inflammatory response. We now show that IA inhibits the production of inflammatory mediators in an in vitro model system of C6 glioma and human peripheral monocytes. Given the involvement of postinjury inflammation in the pathophysiology and outcome of traumatic brain injury, we examined the effect of IA on the inflammatory process and on the recovery of neurobehavioral and cognitive functions in a mouse model of closed head injury (CHI)...
July 2008: Journal of Cerebral Blood Flow and Metabolism
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