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short bowl system

J S Ross, L M Gay, K Wang, J-A Vergilio, J Suh, S Ramkissoon, H Somerset, J M Johnson, J Russell, S Ali, A B Schrock, D Fabrizio, G Frampton, V Miller, P J Stephens, J A Elvin, D W Bowles
Background: Relapsed/metastatic salivary gland carcinomas (SGCs) have a wide diversity of histologic subtypes associated with variable clinical aggressiveness and response to local and systemic therapies. We queried whether comprehensive genomic profiling could define the tumor subtypes and uncover clinically relevant genomic alterations, revealing new routes to targeted therapies for patients with relapsed and metastatic disease. Patients and methods: From a series of 85 686 clinical cases, DNA was extracted from 40 µm of formalin-fixed paraffin embedded (FFPE) sections for 623 consecutive SGC...
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Timothy M Bowles, Louise E Jackson, Timothy R Cavagnaro
Climate change will alter both the amount and pattern of precipitation and soil water availability, which will directly affect plant growth and nutrient acquisition, and potentially, ecosystem functions like nutrient cycling and losses as well. Given their role in facilitating plant nutrient acquisition and water stress resistance, arbuscular mycorrhizal (AM) fungi may modulate the effects of changing water availability on plants and ecosystem functions. The well-characterized mycorrhizal tomato (Solanum lycopersicum L...
January 2018: Global Change Biology
Xinyu Li, Dandan Sun, Xu Li, Dashuai Zhu, Zhenzhen Jia, Jiajia Jiao, Kai Wang, Deling Kong, Xin Zhao, Lin Xu, Qiang Zhao, Dongyan Chen, Xizeng Feng
Carbon nanomaterials have been used to treat neurodegenerative diseases and neural disorders due to their diverse molecular structures. Corannulene is a three-dimensional π-bowl carbon nanomaterial that is different from planar PAHs, fullerenes and carbon nanotubes, but little is known about its biological functions. Herein, corannulene was functionalized with mPEG-DESP to prepare PEGylation corannulene nanoparticles (PEGylation CoNps). The synthesized PEGylation CoNps shows enhanced solubility and reduced aggregation when compared corannulene...
March 28, 2017: Biomaterials Science
Laura Plantinga, S Sam Lim, C Barrett Bowling, Cristina Drenkard
OBJECTIVE: To examine whether older age was associated with lower health-related quality of life (HRQOL) among patients with systemic lupus erythematosus (SLE) and whether differential disease-related damage and activity explained these associations. METHODS: We used cross-sectional data on 684 patients with SLE aged ≥20 years from the Georgians Organized Against Lupus cohort to estimate the associations between age (categorised as 20-39, 40-59 and ≥60 years) and HRQOL (Short Form-12 norm-based domain and physical component summary (PCS) and mental component summary (MCS) scores), using multivariable linear regression...
2016: Lupus Science & Medicine
Masatoshi Hirabayashi, Daniel J Scheeres, Steven R Chesley, Simone Marchi, Jay W McMahon, Jordan Steckloff, Stefano Mottola, Shantanu P Naidu, Timothy Bowling
The solid, central part of a comet--its nucleus--is subject to destructive processes, which cause nuclei to split at a rate of about 0.01 per year per comet. These destructive events are due to a range of possible thermophysical effects; however, the geophysical expressions of these effects are unknown. Separately, over two-thirds of comet nuclei that have been imaged at high resolution show bilobate shapes, including the nucleus of comet 67P/Churyumov-Gerasimenko (67P), visited by the Rosetta spacecraft. Analysis of the Rosetta observations suggests that 67P's components were brought together at low speed after their separate formation...
June 16, 2016: Nature
Julia Fischin, Gamal Chehab, Jutta G Richter, Rebecca Fischer-Betz, Borgi Winkler-Rohlfing, Reinhart Willers, Matthias Schneider
OBJECTIVE: The aim of this study was to identify factors associated with pain coping and catastrophising in patients with systemic lupus erythematosus. METHODS: All patients were participants of the lupus erythematosus long-term study, which is based on patient-reported data assessed among members of the German Lupus Erythematosus Self-Help Organization. Assessments were performed by means of a questionnaire. Among self-reported clinical data the Pain-Related Self Statements Scale (PRSS) was included...
2015: Lupus Science & Medicine
Diana García Sáez, Bartlomiej Zych, Anton Sabashnikov, Christopher T Bowles, Fabio De Robertis, Prashant N Mohite, Aron-Frederik Popov, Olaf Maunz, Nikhil P Patil, Alexander Weymann, Timothy Pitt, Louise McBrearty, Bradley Pates, Rachel Hards, Mohamed Amrani, Toufan Bahrami, Nicholas R Banner, Andre R Simon
BACKGROUND: A severe shortage of available donor organs has created an impetus to use extended criteria organs for heart transplantation. Although such attempts increase donor organ availability, they may result in an adverse donor-recipient risk profile. The TransMedics Organ Care System (OCS) (TransMedics, Inc, Boston) allows preservation of the donor heart by perfusing the organ at 34°C in a beating state, potentially reducing the detrimental effect of cold storage and providing additional assessment options...
December 2014: Annals of Thoracic Surgery
Carlos A Jiménez-Hoyos, R Rodríguez-Guzmán, Gustavo E Scuseria
Most ab initio calculations on fullerene molecules have been carried out on the basis of the paradigm of the Hückel model. This is consistent with the restricted nature of the independent-particle model underlying such calculations, even in single-reference-based correlated approaches. Notwithstanding, previous works on some of these molecules using model Hamiltonians have clearly indicated the importance of short-range interatomic spin-spin correlations. In this work, we consider ab initio non-collinear Hartree-Fock (HF) solutions for representative fullerene systems: the bowl, cage, ring, and pentagon isomers of C20, and the larger C30, C36, C60, C70, and C84 fullerene cages...
October 23, 2014: Journal of Physical Chemistry. A
Thomas W Johnson, Debbie Marsden, Andrew Mumford, Katie Pike, Stuart Mundell, Mark Butler, Julian W Strange, Ruth Bowles, Chris Rogers, Andreas Baumbach, Barnaby C Reeves
BACKGROUND: Optimal treatment of acute ST-elevation myocardial infarction (STEMI) involves rapid diagnosis, and transfer to a cardiac centre capable of percutaneous coronary intervention (PCI) for immediate mechanical revascularisation. Successful treatment requires rapid return of perfusion to the myocardium achieved by thromboaspiration, passivation of the culprit lesion with stent scaffolding and systemic inhibition of thrombosis and platelet activation. A delicate balance exists between thrombosis and bleeding and consequently anti-thrombotic and antiplatelet treatment regimens continue to evolve...
April 4, 2014: BMC Cardiovascular Disorders
Kevin W Southerland, Sarah B Frazier, Dawn E Bowles, Carmelo A Milano, Christopher D Kontos
Ischemic cardiovascular disease remains the leading cause of death worldwide. Despite advances in the medical management of atherosclerosis over the past several decades, many patients require arterial revascularization to reduce mortality and alleviate ischemic symptoms. Technological advancements have led to dramatic increases in the use of percutaneous and endovascular approaches, yet surgical revascularization (bypass surgery) with autologous vein grafts remains a mainstay of therapy for both coronary and peripheral artery disease...
April 2013: Translational Research: the Journal of Laboratory and Clinical Medicine
Lorenz Gygax, Nadine Reefmann, Martin Wolf, Jan Langbein
Recent concepts relating to animal welfare accept that animals experience affective states. These are notoriously difficult to measure in non-verbal species, but it is generally agreed that emotional reactions consist of well-coordinated reactions in behaviour, autonomic and brain activation. The aim of the study was to evaluate whether each or a combination of these aspects can differentiate between situations presumed to differ in emotional content. To this end, we repeatedly confronted dwarf goats at short intervals with a covered and an uncovered feed bowl (i...
February 15, 2013: Behavioural Brain Research
Alistair B A Boxall, Lindsay A Fogg, Roman Ashauer, Teresa Bowles, Chris J Sinclair, Alison Colyer, Richard A Brain
Many contaminants are released into aquatic systems intermittently in a series of pulses. Pulse timing and magnitude can vary according to usage, compound-specific physicochemical properties, and use area characteristics. Standard laboratory ecotoxicity tests typically employ continuous exposure concentrations over defined durations and thus may not accurately and realistically reflect the effects of certain compounds on aquatic organisms, resulting in potential over- or underestimation. Consequently, the relative effects of pulsed (2 and 4 d) and continuous exposures of the duckweed Lemna minor to isoproturon, metsulfuron-methyl, and pentachlorophenol over a period of 42 d were explored in the present study...
January 2013: Environmental Toxicology and Chemistry
Guido Barchiesi, Susan Wache, Luigi Cattaneo
Repeatedly performing similar motor acts produces short-term adaptive changes in the agent's motor system. One striking use-dependent effect is the motor-to-visual aftereffect (MVA), a short-lasting negative bias in the conceptual categorization of visually-presented training-related motor behavior. The MVA is considered the behavioral counterpart of the adaptation of visuomotor neurons that code for congruent executed and observed motor acts. Here we characterize which features of the motor training generate the MVA, along 3 main dimensions: a) the relative role of motor acts vs...
2012: PloS One
Alison C Bowling, Emily A Hindman, James F Donnelly
The relations among spatial memory, Stroop-like colour-word subtests, and errors on antisaccade and memory-guided saccadic eye-movement trials for older and younger adults were tested. Two types of errors in the antisaccade task were identified: short latency prosaccade errors that were immediately corrected and longer latency uncorrected prosaccade errors. The age groups did not differ on percentages of either corrected or uncorrected errors, but the latency and time to correct prosaccade errors were shorter for younger than older adults...
January 2012: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Erin J Aiello Bowles, Melissa L Anderson, Susan D Reed, Katherine M Newton, E Dawn Fitzgibbons, Deborah Seger, Diana S M Buist
BACKGROUND: Breast density tends to decrease when women stop taking hormone therapy (HT). Some women find HT cessation difficult to tolerate, possibly because of fluctuations in endogenous hormone levels and vasomotor symptoms. We hypothesized that women with dense breasts might have lower tolerance for short-term HT suspension than do women with fatty breasts. METHODS: As part of the Radiologic Evaluation And breast Density (READ) trial, we randomly assigned 881 women aged 45-80 with a prior screening (index) mammogram to suspend HT for 1 or 2 months before their next screening (study) mammogram...
August 2010: Journal of Women's Health
Paul D Heideman, Julian T Pittman, Kristin A Schubert, Christen M R Dubois, Jennifer Bowles, Sean M Lowe, Matthew R Price
Natural genetic variation in reproduction and life history strategies is a manifestation of variation in underlying regulatory neuronal and endocrine systems. A test of the hypothesis that genetic variation in luteinizing hormone (LH) level could be related to a life history trait, seasonal reproduction, was conducted on artificial selection lines from a wild-source population of white-footed mice (Peromyscus leucopus). Variation exists in the degree of suppression of reproduction by winter short-day photoperiods (SD) in wild-source individuals and in the laboratory population...
June 2010: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Ilia N Karatsoreos, Sarah M Bhagat, Nicole P Bowles, Zachary M Weil, Donald W Pfaff, Bruce S McEwen
Numerous clinical and experimental studies have linked stress to changes in risk factors associated with the development of physiological syndromes, including metabolic disorders. How different mediators of the stress response, such as corticosterone (CORT), influence these changes in risk remains unclear. Although CORT has beneficial short-term effects, long-term CORT exposure can result in damage to the physiological systems it protects acutely. Disruption of this important physiologic signal is observed in numerous disparate disorders, ranging from depression to Cushing's syndrome...
May 2010: Endocrinology
Josephine Bowles, Chun-Wei Feng, Deon Knight, Craig A Smith, Kelly N Roeszler, Stefan Bagheri-Fam, Vincent R Harley, Andrew H Sinclair, Peter Koopman
Balanced production and degradation of retinoids is important in regulating development of several organ systems in the vertebrate embryo. Among these, it is known that retinoic acid (RA), and the retinoid-catabolyzing enzyme CYP26B1 together regulate the sex-specific behavior of germ cells in developing mouse gonads. We report here that the gene encoding a cytosolic class-1 aldehyde dehydrogenase, ALDH1A1, a weak catalyst of RA production, is strongly expressed in a male-specific manner in somatic cells of the developing mouse testis, beginning shortly after Sry expression is first detectable...
August 2009: Developmental Dynamics: An Official Publication of the American Association of Anatomists
X W Sheng, P Li, K T Tang
The ground state van der Waals potentials of the Hg-RG (RG = He,Ne,Ar,Kr,Xe) systems are generated by the Tang-Toennies potential model. The parameters of the model are calculated from the potentials of the homonuclear mercury and rare-gas dimers with combining rules. The predicted spectroscopic parameters for these mercury rare-gas complexes are in good agreement with available experimental values, except for Hg-He. In the repulsive and potential well regions, the predicted potential energy curves agree with the available experimental hybrid potentials, but they differ in the long range part of the potential...
May 7, 2009: Journal of Chemical Physics
Yasuhide Inokuma, Atsuhiro Osuka
Subporphyrin is a ring-contracted porphyrin congener consisting of three pyrrolic subunits domed in a C3 symmetric bowl arrangement. Subporphyrin had long been elusive until the first synthesis of tribenzosubporphine in 2006. Shortly after, synthetic protocols of subpyriporphyrin, meso-aryl-substituted subporphyrins, and meso-aryl substituted subchlorins were developed. Subporphyrins display interesting properties including distinct aromaticity arising from 14pi-electronic conjugation, green fluorescence, and strong influences of meso-aryl substituents on the electronic network of the macrocycle...
May 21, 2008: Dalton Transactions: An International Journal of Inorganic Chemistry
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