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https://www.readbyqxmd.com/read/28417071/twenty-novel-mutations-in-bckdha-bckdhb-and-dbt-genes-in-a-cohort-of-52-saudi-arabian-patients-with-maple-syrup-urine-disease
#1
Faiqa Imtiaz, Abeer Al-Mostafa, Rabab Allam, Khushnooda Ramzan, Nada Al-Tassan, Asma I Tahir, Nouf S Al-Numair, Mohamed H Al-Hamed, Zuhair Al-Hassnan, Mohammad Al-Owain, Hamad Al-Zaidan, Mohammad Al-Amoudi, Alya Qari, Ameera Balobaid, Moeenaldeen Al-Sayed
Maple syrup urine disease (MSUD), an autosomal recessive inborn error of metabolism due to defects in the branched-chain α-ketoacid dehydrogenase (BCKD) complex, is commonly observed among other inherited metabolic disorders in the kingdom of Saudi Arabia. This report presents the results of mutation analysis of three of the four genes encoding the BCKD complex in 52 biochemically diagnosed MSUD patients originating from Saudi Arabia. The 25 mutations (20 novel) detected spanned across the entire coding regions of the BCKHDA, BCKDHB and DBT genes...
June 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28403940/vitamin-d-replacement-in-children-adolescents-and-pregnant-women-in-the-middle-east-and-north-africa-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Marlene Chakhtoura, Sara El Ghandour, Khaled Shawwa, Elie A Akl, Asma Arabi, Ziyad Mahfoud, Robert Habib, Hassan Hoballah, Ghada El Hajj Fuleihan
INTRODUCTION: Hypovitaminosis D affects one-third to two-thirds of children and pregnant women from the Middle East and North Africa (MENA) region. OBJECTIVE: To evaluate in infants, children, adolescents and pregnant women, from the MENA region, the effect of supplementation with different vitamin D doses on the change in 25-hydroxyvitamin D [25(OH)D] level reached, and other skeletal and non-skeletal outcomes. METHODS: This is a systematic review of randomized controlled trials of vitamin D supplementation conducted in the MENA region...
May 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28398172/men-s-perceptions-of-child-bearing-and-fertility-control-in-pakistan-insights-from-a-peer-project
#3
Eleanor Brown, Xaher Gul, Aamir Abbas, Asim Nasar, Asma Balal
Notions of masculinity, which promote the role of men as providers and decision-makers, alongside men's opposition to modern forms of contraception, have long been assumed to be a barrier to women's use of contraception in Pakistan. There has been little in-depth exploration of varieties of masculinity and how these may influence men's views of child-bearing or fertility preferences. This study used Participatory Ethnographic and Evaluation Research to explore married men's (aged 18 to 45 years) perceptions of marriage, child-bearing and fertility control...
April 11, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28349904/relation-between-dental-caries-and-body-mass-index-for-age-among-schoolchildren-of-jazan-city-kingdom-of-saudi-arabia
#4
Mir Fa Quadri, Bassam M Hakami, Asma Aa Hezam, Raed Y Hakami, Fadwa A Saadi, Layla M Ageeli, Wafqah H Alsagoor, Mohammad A Faqeeh, Mohammed A Dhae
OBJECTIVE: To analyze and report the type of relation present between dental caries and body mass index (BMI)-for-age among schoolchildren in Jazan region of Kingdom of Saudi Arabia. MATERIALS AND METHODS: A cross-sectional study with multi-staged random sampling technique was designed to recruit the sample of schoolchildren. Caries was examined using the World Health Organization recommended "decayed and filled teeth"/"decayed missing and filled teeth (dft/DMFT)" method...
April 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28321303/comparative-study-on-treatment-satisfaction-and-health-perception-in-children-and-adolescents-with-type-1-diabetes-mellitus-on-multiple-daily-injection-of-insulin-insulin-pump-and-sensor-augmented-pump-therapy
#5
Tara Hussain, Mariette Akle, Nico Nagelkerke, Asma Deeb
OBJECTIVES: Diabetes management imposes considerable demands on patients. Treatment method used has an impact on treatment satisfaction. We aim to examine the relationship between treatment satisfaction and health perception with the method used for treatment of type 1 diabetes mellitus in children and adolescents. SUBJECTS AND METHOD: We have interviewed patients with type 1 diabetes mellitus using questionnaires to assess treatment satisfaction and health perception...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28260550/quality-of-life-of-malaysian-children-with-chd
#6
Lai C Ong, Ching S Teh, Joyce Darshinee, Asma Omar, Hak L Ang
OBJECTIVES: The objectives of this study were to compare the quality-of-life scores of Malaysian children with CHD and their healthy siblings, to determine the level of agreement between proxy-reports and child self-reports, and to examine variables that have an impact on quality of life in those with CHD. METHODS: Parental-proxy scores of the Pediatric Quality of Life Inventory 4.0 core scales were obtained for 179 children with CHD and 172 siblings. Intra-class coefficients were derived to determine the levels of proxy-child agreement in 66 children aged 8-18 years...
March 6, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28190553/cervical-spine-imaging-for-young-children-with-inflicted-trauma-expanding-the-injury-pattern
#7
Joanne Baerg, Arul Thirumoorthi, Rosemary Vannix, Asma Taha, Amy Young, Alexander Zouros
AIM: The purpose of this study was to document the incidence and pattern of cervical spine (c-spine) injuries in children below 36months with inflicted trauma. METHODS: An IRB approved, prospective cohort study was performed between July 2011 and January 2016. Inclusion criteria were: age below 36months, loss of consciousness after inflicted trauma, and one initial head computed tomography finding: a subdural, intraventricular, intraparenchymal, subarachnoid hemorrhage, diffuse axonal injury, hypoxic injury, or cerebral edema...
January 30, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28174626/maternal-undernutrition-and-excessive-body-weight-and-risk-of-birth-and-health-outcomes
#8
Md Nuruzzaman Khan, Md Mizanur Rahman, Asma Ahmad Shariff, Md Mostafizur Rahman, Md Shafiur Rahman, Md Aminur Rahman
BACKGROUND: Overweight and obesity are increasing in low- and middle-income countries, while underweight remains a significant health problems. However, the association between double burden of nutrition and risk of adverse birth and health outcomes is still unclear in Bangladesh. The aim of this study was to determine the effect of maternal undernutrition and excessive body weight on a range of maternal and child health outcomes. METHODS: In this study, we used Bangladesh Demographic and Health Survey (BDHS) 2011 and 2014 data sets to cover the maternal, child and non-communicable diseases related health outcomes...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28125150/phenotypes-of-asthma-in-low-income-children-and-adolescents-cluster-analysis
#9
Anna Lucia Barros Cabral, Andrey Wirgues Sousa, Felipe Augusto Rodrigues Mendes, Celso Ricardo Fernandes de Carvalho
Objective: Studies characterizing asthma phenotypes have predominantly included adults or have involved children and adolescents in developed countries. Therefore, their applicability in other populations, such as those of developing countries, remains indeterminate. Our objective was to determine how low-income children and adolescents with asthma in Brazil are distributed across a cluster analysis. Methods: We included 306 children and adolescents (6-18 years of age) with a clinical diagnosis of asthma and under medical treatment for at least one year of follow-up...
January 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28117470/pulmonary-function-in-children-and-adolescents-with-sickle-cell-disease-have-we-paid-proper-attention-to-this-problem
#10
Ana Karine Vieira, Cristina Gonçalves Alvim, Maria Cristina Marquez Carneiro, Cássio da Cunha Ibiapina
Objective: To evaluate pulmonary function and functional capacity in children and adolescents with sickle cell disease. Methods: This was a cross-sectional study involving 70 children and adolescents (8-15 years of age) with sickle cell disease who underwent pulmonary function tests (spirometry) and functional capacity testing (six-minute walk test). The results of the pulmonary function tests were compared with variables related to the severity of sickle cell disease and history of asthma and of acute chest syndrome...
November 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28088009/cardiac-output-and-systemic-vascular-resistance-clinical-assessment-compared-with-a-noninvasive-objective-measurement-in-children-with-shock
#11
Asma Razavi, Christopher J L Newth, Robinder G Khemani, Fernando Beltramo, Patrick A Ross
PURPOSE: To evaluate physician assessment of cardiac output and systemic vascular resistance in patients with shock compared with an ultrasonic cardiac output monitor (USCOM). To explore potential changes in therapy decisions if USCOM data were available using physician intervention answers. STUDY DESIGN: Double-blinded, prospective, observational study in a tertiary hospital pediatric intensive care unit. Forty children (<18years) admitted with shock, requiring ongoing volume resuscitation or inotropic support...
December 28, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/28077477/the-global-asthma-network-rationale-and-methods-for-phase-i-global-surveillance-prevalence-severity-management-and-risk-factors
#12
Philippa Ellwood, M Innes Asher, Nils E Billo, Karen Bissell, Chen-Yuan Chiang, Eamon M Ellwood, Asma El-Sony, Luis García-Marcos, Javier Mallol, Guy B Marks, Neil E Pearce, David P Strachan
The Global Asthma Network (GAN), established in 2012, followed the International Study of Asthma and Allergies in Childhood (ISAAC). ISAAC Phase One involved over 700 000 adolescents and children from 156 centres in 56 countries; it found marked worldwide variation in symptom prevalence of asthma, rhinitis and eczema that was not explained by the current understanding of these diseases; ISAAC Phase Three involved over 1 187 496 adolescents and children (237 centres in 98 countries). It found that asthma symptom prevalence was increasing in many locations especially in low- and middle-income countries where severity was also high, and identified several environmental factors that required further investigation...
January 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28051222/contribution-of-ultrasound-scans-in-the-first-episode-of-urinary-tract-infection-in-children
#13
Manel Jellouli, Asma Ben Mansour, Kamel Abidi, Meriem Ferjani, Ouns Naija, Yousra Hammi, Chokri Zarrouk, Tahar Gargah
Background - Vesicoureteral reflux (VUR) is a common pediatric urologic disorder. After the first urinary tract infection (UTI), imaging studies are recommended, starting with a renal ultrasound (US) and voiding cystourethrography (VCUG). We propose to determine whether abnormalities found on US can help indicate the necessity of VCUG in children after the first urinary tract infection. Methods - A retrospective study included all children admitted with their first episode of urinary tract infection from January 2007 to December 2012...
June 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28051218/parental-satisfaction-of-an-assessment-unit-for-autistic-spectrum-disorders
#14
Arwa Ben Amor, Soumeyya Halayem, Maissa Touati, Ahlem Belhadj, Riadh Gouider, Ridha Mrad, Asma Bouden
Background - Based on the recognized principles of assessment of autistic disorders, the child and adolescent psychiatry department in Razi Hospital developed an assessment unit with diagnostic as well as therapeutic roles. The aim of this work was to examine its functioning and to analyze the parents' perceptions about the unit services. Methods - We gathered the parental satisfaction about the unit by the means of a hetero-questionnaire. Results - Fifty-two parents of children evaluated within the unit were included...
June 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/27928080/burden-of-diarrhea-in-the-eastern-mediterranean-region-1990-2013-findings-from-the-global-burden-of-disease-study-2013
#15
Ibrahim Khalil, Danny V Colombara, Mohammad Hossein Forouzanfar, Christopher Troeger, Farah Daoud, Maziar Moradi-Lakeh, Charbel El Bcheraoui, Puja C Rao, Ashkan Afshin, Raghid Charara, Kalkidan Hassen Abate, Mohammed Magdy Abd El Razek, Foad Abd-Allah, Remon Abu-Elyazeed, Aliasghar Ahmad Kiadaliri, Ali Shafqat Akanda, Nadia Akseer, Khurshid Alam, Deena Alasfoor, Raghib Ali, Mohammad A AlMazroa, Mahmoud A Alomari, Rajaa Mohammad Salem Al-Raddadi, Ubai Alsharif, Shirina Alsowaidi, Khalid A Altirkawi, Nelson Alvis-Guzman, Walid Ammar, Carl Abelardo T Antonio, Hamid Asayesh, Rana Jawad Asghar, Suleman Atique, Ashish Awasthi, Umar Bacha, Alaa Badawi, Aleksandra Barac, Neeraj Bedi, Tolesa Bekele, Isabela M Bensenor, Balem Demtsu Betsu, Zulfiqar Bhutta, Aref A Bin Abdulhak, Zahid A Butt, Hadi Danawi, Manisha Dubey, Aman Yesuf Endries, Imad D A Faghmous, Talha Farid, Maryam S Farvid, Farshad Farzadfar, Seyed-Mohammad Fereshtehnejad, Florian Fischer, Joseph Robert Anderson Fitchett, Katherine B Gibney, Ibrahim Abdelmageem Mohamed Ginawi, Melkamu Dedefo Gishu, Harish Chander Gugnani, Rahul Gupta, Gessessew Bugssa Hailu, Randah Ribhi Hamadeh, Samer Hamidi, Hilda L Harb, Mohammad T Hedayati, Mohamed Hsairi, Abdullatif Husseini, Nader Jahanmehr, Mehdi Javanbakht, Tariku Jibat, Jost B Jonas, Amir Kasaeian, Yousef Saleh Khader, Abdur Rahman Khan, Ejaz Ahmad Khan, Gulfaraz Khan, Tawfik Ahmed Muthafer Khoja, Yohannes Kinfu, Niranjan Kissoon, Ai Koyanagi, Aparna Lal, Asma Abdul Abdul Latif, Raimundas Lunevicius, Hassan Magdy Abd El Razek, Azeem Majeed, Reza Malekzadeh, Alem Mehari, Alemayehu B Mekonnen, Yohannes Adama Melaku, Ziad A Memish, Walter Mendoza, Awoke Misganaw, Layla Abdalla Ibrahim Mohamed, Jean B Nachega, Quyen Le Nguyen, Muhammad Imran Nisar, Emmanuel Kwame Peprah, James A Platts-Mills, Farshad Pourmalek, Mostafa Qorbani, Anwar Rafay, Vafa Rahimi-Movaghar, Sajjad Ur Rahman, Rajesh Kumar Rai, Saleem M Rana, Chhabi L Ranabhat, Sowmya R Rao, Amany H Refaat, Mark Riddle, Gholamreza Roshandel, George Mugambage Ruhago, Muhammad Muhammad Saleh, Juan R Sanabria, Monika Sawhney, Sadaf G Sepanlou, Tesfaye Setegn, Karen Sliwa, Chandrashekhar T Sreeramareddy, Bryan L Sykes, Mohammad Tavakkoli, Bemnet Amare Tedla, Abdullah S Terkawi, Kingsley Ukwaja, Olalekan A Uthman, Ronny Westerman, Mamo Wubshet, Muluken A Yenesew, Naohiro Yonemoto, Mustafa Z Younis, Zoubida Zaidi, Maysaa El Sayed Zaki, Abdullah A Al Rabeeah, Haidong Wang, Mohsen Naghavi, Theo Vos, Alan D Lopez, Christopher J L Murray, Ali H Mokdad
Diarrheal diseases (DD) are leading causes of disease burden, death, and disability, especially in children in low-income settings. DD can also impact a child's potential livelihood through stunted physical growth, cognitive impairment, and other sequelae. As part of the Global Burden of Disease Study, we estimated DD burden, and the burden attributable to specific risk factors and particular etiologies, in the Eastern Mediterranean Region (EMR) between 1990 and 2013. For both sexes and all ages, we calculated disability-adjusted life years (DALYs), which are the sum of years of life lost and years lived with disability...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27872168/accurate-carbohydrate-counting-is-an-important-determinant-of-postprandial-glycemia-in-children-and-adolescents-with-type-1-diabetes-on-insulin-pump-therapy
#16
Asma Deeb, Ahlam Al Hajeri, Iman Alhmoudi, Nico Nagelkerke
BACKGROUND: Carbohydrate (CHO) counting is a key nutritional intervention utilized in the management of diabetes to optimize postprandial glycemia. The aim of the study was to examine the impact of accuracy of CHO counting on the postprandial glucose in children and adolescents with type 1 diabetes on insulin pump therapy. METHODS: Children/adolescents with type 1 diabetes who were on insulin pump therapy for a minimum of 6 months are enrolled in the study. Patients were instructed to record details of meals consumed, estimated CHO count per meal, and 2-hour postprandial glucose readings over 3-5 days...
November 20, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27805239/effects-of-ramadan-intermittent-fasting-on-north-african-children-s-heart-rate-and-oxy-haemoglobin-saturation-at-rest-and-during-sub-maximal-exercise
#17
Mohamed Amine Fenneni, Imed Latiri, Asma Aloui, Sonia Rouatbi, Karim Chamari, Helmi Ben Saad
AIM: To examine the effects of Ramadan intermittent fasting (RIF) on the heart rate (HR) and oxyhaemoglobin saturation levels (oxy-sat) of boys at rest and during a six-minute walking test (6MWT). METHODS: Eighteen boys (age: 11.9 ± 0.8 years, height: 153.00 ± 8.93 cm, body mass: 55.4 ± 18.2 kg), who fasted the entire month of Ramadan in 2012 for the first time in their lives, were included. The experimental protocol comprised four testing phases: two weeks before Ramadan (pre-R), the end of the second week of Ramadan (R-2), the end of the fourth week of Ramadan (R-4), and 10 to 12 days after the end of Ramadan (post-R)...
October 21, 2016: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/27687031/transgenic-expression-of-phytase-in-wheat-endosperm-increases-bioavailability-of-iron-and-zinc-in-grains
#18
Nabeela Abid, Asia Khatoon, Asma Maqbool, Muhammad Irfan, Aftab Bashir, Irsa Asif, Muhammad Shahid, Asma Saeed, Henrik Brinch-Pedersen, Kauser A Malik
Phytate is a major constituent of wheat seeds and chelates metal ions, thus reducing their bioavailability and so the nutritional value of grains. Transgenic plants expressing heterologous phytase are expected to enhance degradation of phytic acid stored in seeds and are proposed to increase the in vitro bioavailability of mineral nutrients. Wheat transgenic plants expressing Aspergillus japonicus phytase gene (phyA) in wheat endosperm were developed till T3 generation. The transgenic lines exhibited 18-99 % increase in phytase activity and 12-76 % reduction of phytic acid content in seeds...
February 2017: Transgenic Research
https://www.readbyqxmd.com/read/27677120/the-effects-of-arsenic-contaminated-drinking-water-of-livestock-on-its-total-levels-in-milk-samples-of-different-cattle-risk-assessment-in-children
#19
Tasneem Gul Kazi, Kapil Dev Brahman, Hassan Imran Afridi, Mohammad Balal Arain, Farah Naz Talpur, Asma Akhtar
This work was carried out to evaluate the arsenic (As) levels in milk samples of different milch animals, sheep, goats, cows, buffaloes and camels in Tharparkar, Pakistan. The concentration of As in the milk samples of cows, buffalos, sheep, goats and camels were observed in the range of 15.1-18.4, 2.6-7.7, 25.7-33.2, 10.5-37.3 and 6.6-13.7 μg/L, respectively. The levels of As in livestock drinking water of each farms/flocks was found in the range of 238-2000 μg L(-1). A positive correlation with Pearson correlation coefficients, ranged as, 0...
December 2016: Chemosphere
https://www.readbyqxmd.com/read/27676398/the-relationship-between-calciotropic-hormones-igf-1-and-bone-mass-across-pubertal-stages
#20
Maria Matar, Laila Al-Shaar, Joyce Maalouf, Mona Nabulsi, Asma Arabi, Mahmoud Choucair, Hani Tamim, Ghada El-Hajj Fuleihan
BACKGROUND: Little is known about the changes in calciotropic hormones during puberty and their relationship to bone mass during this critical period for skeletal accretion. OBJECTIVES: Investigate changes in calciotropic hormones, IGF-1, body composition, and their associations with bone metabolism in adolescents. METHODS: Post hoc analyses were performed from data on 335 healthy school children, ages 10-17 years, with hypovitaminosis D who participated in a vitamin D randomized controlled trial...
December 2016: Journal of Clinical Endocrinology and Metabolism
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