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JOURNAL ARTICLE
Adam G Culvenor, Thomas J West, Andrea M Bruder, Mark J Scholes, Christian J Barton, Ewa M Roos, Edwin H G Oei, Steven M McPhail, Richard B Souza, Jusuk Lee, Brooke E Patterson, Michael A Girdwood, Jamon L Couch, Kay M Crossley
OBJECTIVES: The study aims to (1) report the process of recruiting young adults into a secondary knee osteoarthritis prevention randomised controlled trial (RCT) after anterior cruciate ligament reconstruction (ACLR); (2) determine the number of individuals needed to be screened to include one participant (NNS) and (3) report baseline characteristics of randomised participants. METHODS: The SUpervised exercise-therapy and Patient Education Rehabilitation (SUPER)-Knee RCT compares SUPER and minimal intervention for young adults (aged 18-40 years) with ongoing symptoms (ie, mean score of <80/100 from four Knee injury and Osteoarthritis Outcome Score subscales (KOOS4 )) 9-36 months post-ACLR...
2024: BMJ Open Sport & Exercise Medicine
#22
JOURNAL ARTICLE
Lucy Hyam, Olivia Yeadon-Ray, Katie Richards, Amy Semple, Karina Allen, Jill Owens, Aileen Jackson, Laura Semple, Danielle Glennon, Giulia Di Clemente, Jess Griffiths, Regan Mills, Ulrike Schmidt
INTRODUCTION: First Episode Rapid Early Intervention for Eating Disorders (FREED) is the leading eating disorder (ED) early intervention model for young people. Research has shown that it reduces the duration of untreated illness, improves clinical outcomes, and has cost savings. However, less is known about the experience of implementing FREED. This study aimed to investigate the views and experiences of adopting, implementing, and sustaining FREED from the perspective of clinical staff...
2024: Frontiers in Psychiatry
#23
JOURNAL ARTICLE
Gregory M Fosco, Shichen Fang, Lan Chen, Mark E Feinberg, Richard Spoth
The loss of John Schulenberg reverberates across the developmental and prevention sciences. In honor of his many contributions, this paper applies his ideas of developmental continuity and discontinuity to understand the process by which PROSPER delivered universal prevention programs (delivered in Grades 6 and 7) affect young adult outcomes. Guided by these developmental models, we deconstructed adolescent substance use initiation trajectories into two discrete phases-early and late adolescence, demarcated by substance use initiation levels at the end of 9th grade...
April 9, 2024: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
#24
RANDOMIZED CONTROLLED TRIAL
Candice M Monson, Nicole D Pukay-Martin, Anne C Wagner, Alexander O Crenshaw, Tabatha H Blount, Richard P Schobitz, Katherine A Dondanville, Stacey Young-McCaughan, Jim Mintz, David S Riggs, Antoinette Brundige, Elizabeth A Hembree, Brett T Litz, John D Roache, Jeffrey S Yarvis, Alan L Peterson
Military personnel and veterans are at heightened risk for exposure to traumatic events and posttraumatic stress disorder (PTSD), as well as intimate relationship problems associated with PTSD. The purpose of this study was to evaluate the relative efficacy of CBCT and PE in improving intimate relationship functioning in active duty military personnel or veterans and their intimate partners; both conditions were hypothesized to significantly improve PTSD. Method: In this study, 32 military service members or veterans with PTSD and their intimate partners were randomized to receive either Cognitive-Behavioral Conjoint Therapy for PTSD ( n = 15; CBCT; [Monson, C...
2024: European Journal of Psychotraumatology
#25
JOURNAL ARTICLE
Xinyu Bai, Grace H Attrill, Tuba N Gide, Peter M Ferguson, Kazi J Nahar, Ping Shang, Ismael A Vergara, Umaimainthan Palendira, Ines Pires da Silva, Matteo S Carlino, Alexander M Menzies, Georgina V Long, Richard A Scolyer, James S Wilmott, Camelia Quek
The biological underpinnings of therapeutic resistance to immune checkpoint inhibitors (ICI) in adolescent and young adult (AYA) melanoma patients are incompletely understood. Here, we characterize the immunogenomic profile and spatial architecture of the tumor microenvironment (TME) in AYA (aged ≤ 30 years) and older adult (aged 31-84 years) patients with melanoma, to determine the AYA-specific features associated with ICI treatment outcomes. We identify two ICI-resistant spatiotypes in AYA patients with melanoma showing stroma-infiltrating lymphocytes (SILs) that are distinct from the adult TME...
April 8, 2024: Nature Communications
#26
JOURNAL ARTICLE
Seemab Paul, Andrew MacNair, Vasileios Lostarakos, Richard Capstick
People who have structural or developmental lung disease are more likely to develop non-tuberculous mycobacterial infections. We present the case of a young man in his 30s who had unilateral pulmonary artery agenesis on the right side and presented with a 6-month history of productive cough and fever. His CT scan showed nodular and cavitating lesions on the right side, and sputum analysis confirmed infection with Mycobacterium chimaera He had to undergo modifications in his treatment, including a change from rifampicin to rifabutin due to drug interactions and his amikacin had to be stopped due to signs of vestibular toxicity...
April 8, 2024: BMJ Case Reports
#27
REVIEW
Aimee C Talleur, Vanessa A Fabrizio, Richard Aplenc, Stephan A Grupp, Crystal Mackall, Robbie Majzner, Rosa Nguyen, Rayne Rouce, Amy Moskop, Kevin O McNerney
Chimeric antigen receptor (CAR) T cell therapy has demonstrated remarkable efficacy in relapsed/refractory (r/r) B cell malignancies, including in pediatric patients with acute lymphoblastic leukemia (ALL). Expanding this success to other hematologic and solid malignancies is an area of active research and, although challenges remain, novel solutions have led to significant progress over the past decade. Ongoing clinical trials for CAR T cell therapy for T cell malignancies and acute myeloid leukemia (AML) have highlighted challenges, including antigen specificity with off-tumor toxicity and persistence concerns...
April 6, 2024: Transplantation and cellular therapy
#28
JOURNAL ARTICLE
Seemal F Awan, Amarendra Pegu, Larisa Strom, Cristina A Carter, Cynthia S Hendel, LaSonji A Holman, Pamela J Costner, Olga Trofymenko, Renunda Dyer, Ingelise J Gordon, Ro Shauna S Rothwell, Somia P Hickman, Michelle Conan-Cibotti, Nicole A Doria-Rose, Bob C Lin, Sarah O'Connell, Sandeep R Narpala, Cassandra G Almasri, Cuiping Liu, Sungyoul Ko, Young D Kwon, Aryan M Namboodiri, Janardan P Pandey, Frank J Arnold, Kevin Carlton, Jason G Gall, Peter D Kwong, Edmund V Capparelli, Robert T Bailer, Adrian B McDermott, Grace L Chen, Richard A Koup, John R Mascola, Emily E Coates, Julie E Ledgerwood, Martin R Gaudinski
BACKGROUNDBroadly neutralizing monoclonal antibodies (bNAbs) represent a promising strategy for HIV-1 immunoprophylaxis and treatment. 10E8VLS and VRC07-523LS are bNAbs that target the highly conserved membrane-proximal external region (MPER) and the CD4-binding site of the HIV-1 viral envelope glycoprotein, respectively.METHODSIn this phase 1, open-label trial, we evaluated the safety and pharmacokinetics of 5 mg/kg 10E8VLS administered alone, or concurrently with 5 mg/kg VRC07-523LS, via s.c. injection to healthy non-HIV-infected individuals...
April 8, 2024: JCI Insight
#29
JOURNAL ARTICLE
Stylianos Tzeis, Edward P Gerstenfeld, Jonathan Kalman, Eduardo B Saad, Alireza Sepehri Shamloo, Jason G Andrade, Chirag R Barbhaiya, Tina Baykaner, Serge Boveda, Hugh Calkins, Ngai-Yin Chan, Minglong Chen, Shih-Ann Chen, Nikolaos Dagres, Ralph J Damiano, Tom De Potter, Isabel Deisenhofer, Nicolas Derval, Luigi Di Biase, Mattias Duytschaever, Katia Dyrda, Gerhard Hindricks, Meleze Hocini, Young-Hoon Kim, Mark la Meir, Jose Luis Merino, Gregory F Michaud, Andrea Natale, Isabelle Nault, Santiago Nava, Takashi Nitta, Mark O'Neill, Hui-Nam Pak, Jonathan P Piccini, Helmut Pürerfellner, Tobias Reichlin, Luis Carlos Saenz, Prashanthan Sanders, Richard Schilling, Boris Schmidt, Gregory E Supple, Kevin L Thomas, Claudio Tondo, Atul Verma, Elaine Y Wan, Daniel Steven, Michael-Joseph Agbayani, T Jared Bunch, Aman Chugh, Juan Carlos Díaz, James V Freeman, Carina Abigail Hardy, Hein Heidbuchel, Sofian Johar, Dominik Linz, Bart Maesen, Peter A Noseworthy, Seil Oh, Andreu Porta-Sanchez, Tatjana Potpara, Gerardo Rodriguez-Diez, Frederic Sacher, Piotr Suwalski, Serge A Trines
In the last three decades, ablation of atrial fibrillation (AF) has become an evidence-based safe and efficacious treatment for managing the most common cardiac arrhythmia. In 2007, the first joint expert consensus document was issued, guiding healthcare professionals involved in catheter or surgical AF ablation. Mounting research evidence and technological advances have resulted in a rapidly changing landscape in the field of catheter and surgical AF ablation, thus stressing the need for regularly updated versions of this partnership which were issued in 2012 and 2017...
March 30, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#30
JOURNAL ARTICLE
C Barrett Bowling, Richard A Faldowski, Richard Sloane, Carl Pieper, Tyson H Brown, Erin E Dooley, Brett T Burrows, Norrina B Allen, Kelley Pettee Gabriel, Cora E Lewis
BACKGROUND: Multimorbidity research has focused on the prevalence and consequences of multimorbidity in older populations. Less is known about the accumulation of chronic conditions earlier in the life course. METHODS: We identified patterns of longitudinal multimorbidity accumulation using 30 years of data from in-person exams, annual follow-ups, and adjudicated end-points among 4,945 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study...
2024: J Multimorb Comorb
#31
JOURNAL ARTICLE
Ebraham Alskaf, Richard Crawley, Cian M Scannell, Avan Suinesiaputra, Alistair Young, Pier-Giorgio Masci, Divaka Perera, Amedeo Chiribiri
BACKGROUND: Prediction of clinical outcomes in coronary artery disease (CAD) has been conventionally achieved using clinical risk factors. The relationship between imaging features and outcome is still not well understood. This study aims to use artificial intelligence to link image features with mortality outcome. METHODS: A retrospective study was performed on patients who had stress perfusion cardiac magnetic resonance (SP-CMR) between 2011 and 2021. The endpoint was all-cause mortality...
March 30, 2024: Journal of medical artificial intelligence
#32
JOURNAL ARTICLE
Richard E Ahl, Dorsa Amir, Katherine McAuliffe
Does a sense of having less or more than what one needs affect one's generosity? The question of how resource access influences prosocial behavior has received much attention in studies with adults but has produced conflicting findings. To better understand this relationship, we tested whether resource access affects generosity in the developing mind. In our preregistered investigation, we used a narrative recall method to explore how temporary, experimentally evoked states of resource abundance or scarcity affect children's sharing...
April 5, 2024: Journal of Experimental Child Psychology
#33
JOURNAL ARTICLE
Helena I M Boshoff, Katherine Young, Yong-Mo Ahn, Veena D Yadav, Brendan M Crowley, Lihu Yang, Jing Su, Sangmi Oh, Kriti Arora, Jenna Andrews, Michelle Manikkam, Michelle Sutphin, Anthony J Smith, Danielle M Weiner, Michaela K Piazza, Joel D Fleegle, Felipe Gomez, Emmannual K Dayao, Brendan Prideaux, Matthew Zimmerman, Firat Kaya, Jansy Sarathy, Vee Yang Tan, Laura E Via, Richard Tschirret-Guth, Anne J Lenaerts, Gregory T Robertson, Véronique Dartois, David B Olsen, Clifton E Barry
Linezolid is a drug with proven human antitubercular activity whose use is limited to highly drug-resistant patients because of its toxicity. This toxicity is related to its mechanism of action─linezolid inhibits protein synthesis in both bacteria and eukaryotic mitochondria. A highly selective and potent series of oxazolidinones, bearing a 5-aminomethyl moiety (in place of the typical 5-acetamidomethyl moiety of linezolid), was identified. Linezolid-resistant mutants were cross-resistant to these molecules but not vice versa...
April 6, 2024: ACS Infectious Diseases
#34
JOURNAL ARTICLE
Richard M Martin, Emma L Turner, Grace J Young, Chris Metcalfe, Eleanor I Walsh, J Athene Lane, Jonathan A C Sterne, Sian Noble, Peter Holding, Yoav Ben-Shlomo, Naomi J Williams, Nora Pashayan, Mai Ngoc Bui, Peter C Albertsen, Tyler M Seibert, Anthony L Zietman, Jon Oxley, Jan Adolfsson, Malcolm D Mason, George Davey Smith, David E Neal, Freddie C Hamdy, Jenny L Donovan
IMPORTANCE: The Cluster Randomized Trial of PSA Testing for Prostate Cancer (CAP) reported no effect of prostate-specific antigen (PSA) screening on prostate cancer mortality at a median 10-year follow-up (primary outcome), but the long-term effects of PSA screening on prostate cancer mortality remain unclear. OBJECTIVE: To evaluate the effect of a single invitation for PSA screening on prostate cancer-specific mortality at a median 15-year follow-up compared with no invitation for screening...
April 6, 2024: JAMA
#35
JOURNAL ARTICLE
Richard Nyeko, Nelson Okello, Christine Joy Abeja, Proscovia Adyanga, Betty Apio, Caroline Kambugu Nabasirye, Pamella Aol Mwa, Racheal Angom, Fadhil Geriga, Julie Buser
Purpose: Reproductive health (RH) is a critical issue among cancer survivors worldwide. However, in developing countries where RH services for patients with cancer are often lacking, reproductive concerns among adolescent and young adult (AYA) survivors remain uncertain. In this study, we assessed the reproductive concerns of AYA cancer survivors in a resource-limited context of Uganda. Methods: We collected data from AYA cancer survivors at two facilities in Uganda using an interviewer-administered questionnaire...
April 5, 2024: Journal of Adolescent and Young Adult Oncology
#36
JOURNAL ARTICLE
Lindsey J Patton, Angelica Morris, Amanda Nash, Kendel Richards, Leslie Huntington, Lori Batchelor, Jenna Harris, Virginia Young, Carol J Howe
BACKGROUND: Pediatric patients require central venous catheters to maintain adequate hydration, nutritional status, and delivery of life-saving medications in the pediatric intensive care unit. Although central venous catheters provide critical medical therapies, their use increases the risk of severe infection, morbidity, and mortality. Adopting an evidence-based central line-associated bloodstream infection (CLABSI) bundle to guide nursing practice can decrease and sustain low CLABSI rates, but reliable and consistent implementation is challenging...
2024: Pediatric Quality & Safety
#37
JOURNAL ARTICLE
Neetika Gupta, Elka Miller, Aashim Bhatia, Julie Richer, Richard I Aviv, Nagwa Wilson
Monogenic cerebral vasculopathy is a rare but progressively recognizable cause of pediatric cerebral vasculopathy manifesting as early as fetal life. These monogenic cerebral vasculopathies can be silent or manifest variably as fetal or neonatal distress, neurologic deficit, developmental delay, cerebral palsy, seizures, or stroke. The radiologic findings can be nonspecific, but the presence of disease-specific cerebral and extracerebral imaging features can point to a diagnosis and guide genetic testing, allowing targeted treatment...
May 2024: Radiographics: a Review Publication of the Radiological Society of North America, Inc
#38
JOURNAL ARTICLE
Ethel Quayle, Matthias Schwannauer, Filippo Varese, Kim Cartwright, Will Hewins, Cindy Chan, Alice Newton, Prathiba Chitsabesan, Cathy Richards, Sandra Bucci
INTRODUCTION: Online child sexual abuse (OCSA) affects considerable numbers of children globally and is associated with a variety of mental health problems. Existing practitioner studies suggest that young people are infrequently asked about online abuse and practitioners have a fragmented understanding of the problems experienced or how they might approach them. There are very few evidence-based interventions that guide clinical assessment or practice. Digital Health Interventions (DHIs) have the potential to be an effective option where children and young people's services are challenged, including accessibility and anonymity...
2024: Frontiers in digital health
#39
JOURNAL ARTICLE
Stephanie Ruth Young, Elizabeth McManus Dworak, Greg J Byrne, Callie Madison Jones, Julia Yoshino Benavente, Lihua Yao, Laura M Curtis, Maria Varela Diaz, Richard Gershon, Michael Wolf, Cindy Nowinski
INTRODUCTION: Annual cognitive screening in older adults is essential for early detection of cognitive impairment, yet primary care settings face time constraints that present barriers to routine screening. A remote cognitive screener completed on a patient's personal smartphone before a visit has the potential to save primary care clinics time, encourage broader screening practices and increase early detection of cognitive decline. MyCog Mobile is a promising new remote smartphone-based cognitive screening app for primary care settings...
April 2, 2024: BMJ Open
#40
JOURNAL ARTICLE
Amie J Eisfeld, Lindsey N Anderson, Shufang Fan, Kevin B Walters, Peter J Halfmann, Danielle Westhoff Smith, Larissa B Thackray, Qing Tan, Amy C Sims, Vineet D Menachery, Alexandra Schäfer, Timothy P Sheahan, Adam S Cockrell, Kelly G Stratton, Bobbie-Jo M Webb-Robertson, Jennifer E Kyle, Kristin E Burnum-Johnson, Young-Mo Kim, Carrie D Nicora, Zuleyma Peralta, Alhaji U N'jai, Foday Sahr, Harm van Bakel, Michael S Diamond, Ralph S Baric, Thomas O Metz, Richard D Smith, Yoshihiro Kawaoka, Katrina M Waters
Human infections caused by viral pathogens trigger a complex gamut of host responses that limit disease, resolve infection, generate immunity, and contribute to severe disease or death. Here, we present experimental methods and multi-omics data capture approaches representing the global host response to infection generated from 45 individual experiments involving human viruses from the Orthomyxoviridae, Filoviridae, Flaviviridae, and Coronaviridae families. Analogous experimental designs were implemented across human or mouse host model systems, longitudinal samples were collected over defined time courses, and global multi-omics data (transcriptomics, proteomics, metabolomics, and lipidomics) were acquired by microarray, RNA sequencing, or mass spectrometry analyses...
April 2, 2024: Scientific Data
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