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Richard A Young

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https://www.readbyqxmd.com/read/29925097/-quality-and-satisfaction-with-the-surgical-medical-clerkship-from-a-student-perspective
#1
Susanne Froehlich, Florian Goebel, Adrian Meder, Janine Wirkner, Udo Obertacke, Richard Kasch
PREFACE: The surgical medical clerkship is of special importance, as the student is given the opportunity to get in touch with medical colleagues and patients for the first time, and the interest in a certain field of specialisation can be consolidated. The present study will clarify how students perceived their medical clerkship in the field of surgery. METHODS: A nationwide online survey carried out in 2012 was able to recruit 9079 participants, and contained questions about the completed curricular internships...
June 20, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29924070/quantitative-evaluation-of-lower-extremity-joint-contractures-in-spinal-muscular-atrophy-implications-for-motor-function
#2
Rachel Salazar, Jacqueline Montes, Sally Dunaway Young, Michael P McDermott, William Martens, Amy Pasternak, Janet Quigley, Elizabeth Mirek, Allan M Glanzman, Matt Civitello, Richard Gee, Tina Duong, Elena S Mazzone, Marion Main, Anna Mayhew, Danielle Ramsey, Robert Muni Lofra, Giorgia Coratti, Lavinia Fanelli, Roberto De Sanctis, Nicola Forcina, Claudia Chiriboga, Basil T Darras, Gihan I Tennekoon, Mariacristina Scoto, John W Day, Richard Finkel, Francesco Muntoni, Eugenio Mercuri, Darryl C De Vivo
PURPOSE: To quantitatively describe passive lower extremity range of motion in participants with spinal muscular atrophy (SMA) types 2 and 3, and to establish preliminary thresholds to identify individuals at risk for performing poorly on disease-specific motor function outcome measures. METHODS: Eighty participants with SMA types 2 and 3, enrolled in an international multicenter natural history study, were evaluated with lower extremity range of motion testing and the Hammersmith Functional Motor Scale-Expanded...
July 2018: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/29922577/an-unusual-cause-of-lone-atrial-fibrillation-in-a-young-female-subject-due-to-a-rapid-cycling-focal-atrial-trigger
#3
Shankar Baskar, Mehran Attari, Richard J Czosek, Pierre Jais, Jeffrey B Anderson, David S Spar
No abstract text is available yet for this article.
June 2018: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/29915101/proteomic-architecture-of-human-coronary-and-aortic-atherosclerosis
#4
David M Herrington, Chunhong Mao, Sarah J Parker, Zongming Fu, Guoqiang Yu, Lulu Chen, Vidya Venkatraman, Yi Fu, Yizhi Wang, Timothy D Howard, Goo Jun, Caroline F Zhao, Yongmei Liu, Georgia Saylor, Weston R Spivia, Grace B Athas, Dana Troxclair, James E Hixson, Richard S Vander Heide, Yue Wang, Jennifer E Van Eyk
BACKGOUND: The inability to detect premature atherosclerosis significantly hinders implementation of personalized therapy to prevent coronary heart disease. A comprehensive understanding of arterial protein networks and how they change in early atherosclerosis could identify new biomarkers for disease detection and improved therapeutic targets. METHODS: Here we describe the human arterial proteome and proteomic features strongly associated with early atherosclerosis based on mass spectrometry analysis of coronary artery and aortic specimens from 100 autopsied young adults (200 arterial specimens)...
June 19, 2018: Circulation
https://www.readbyqxmd.com/read/29914035/ketogenic-medium-chain-triglycerides-increase-brain-energy-metabolism-in-alzheimer-s-disease
#5
Etienne Croteau, Christian-Alexandre Castellano, Marie Anne Richard, Mélanie Fortier, Scott Nugent, Martin Lepage, Simon Duchesne, Kevin Whittingstall, Éric E Turcotte, Christian Bocti, Tamàs Fülöp, Stephen C Cunnane
BACKGROUND: In Alzheimer's disease (AD), it is unknown whether the brain can utilize additional ketones as fuel when they are derived from a medium chain triglyceride (MCT) supplement. OBJECTIVE: To assess whether brain ketone uptake in AD increases in response to MCT as it would in young healthy adults. METHODS: Mild-moderate AD patients sequentially consumed 30 g/d of two different MCT supplements, both for one month: a mixture of caprylic (55%) and capric acids (35%) (n = 11), followed by a wash-out and then tricaprylin (95%; n = 6)...
June 9, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29912328/the-impact-of-cancer-on-subsequent-chance-of-pregnancy-a-population-based-analysis
#6
Richard A Anderson, David H Brewster, Rachael Wood, Sian Nowell, Colin Fischbacher, Tom W Kelsey, W Hamish B Wallace
STUDY QUESTION: What is the impact of cancer in females aged ≤39 years on subsequent chance of pregnancy? SUMMARY ANSWER: Cancer survivors achieved fewer pregnancies across all cancer types, and the chance of achieving a first pregnancy was also lower. WHAT IS KNOWN ALREADY: The diagnosis and treatment of cancer in young females may be associated with reduced fertility but the true pregnancy deficit in a population is unknown. STUDY DESIGN, SIZE, DURATION: We performed a retrospective cohort study relating first incident cancer diagnosed between 1981 and 2012 to subsequent pregnancy in all female patients in Scotland aged 39 years or less at cancer diagnosis (n = 23 201)...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29912205/the-mplex-protocol-for-multi-omic-analyses-of-soil-samples
#7
Carrie D Nicora, Kristin E Burnum-Johnson, Ernesto S Nakayasu, Cameron P Casey, Richard A White, Taniya Roy Chowdhury, Jennifer E Kyle, Young-Mo Kim, Richard D Smith, Thomas O Metz, Janet K Jansson, Erin S Baker
Mass spectrometry (MS)-based integrated metaproteomic, metabolomic, and lipidomic (multi-omic) studies are transforming our ability to understand and characterize microbial communities in environmental and biological systems. These measurements are even enabling enhanced analyses of complex soil microbial communities, which are the most complex microbial systems known to date. Multi-omic analyses, however, do have sample preparation challenges, since separate extractions are typically needed for each omic study, thereby greatly amplifying the preparation time and amount of sample required...
May 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29911113/survival-outcomes-for-advanced-kidney-cancer-patients-in-the-era-of-targeted-therapies
#8
Arpit Rao, Charles Wiggins, Richard C Lauer
Background: Advanced renal cell carcinoma (RCC) results in over 14,000 deaths each year in the United States alone. The therapeutic landscape for advanced RCC changed dramatically with the approval of tyrosine kinase inhibitors (TKI) between 2006 and 2012. A large-scale analysis of survival trends has not been performed in the TKI era to determine their impact on outcomes for advanced RCC patients. Methods: The Surveillance, Epidemiology and End-Results (SEER) database was queried for adult patients with advanced RCC diagnosed between 2000 and 2013...
May 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29910321/predictors-of-swimming-ability-among-children-and-adolescents-in-the-united-states
#9
Jennifer Pharr, Carol Irwin, Todd Layne, Richard Irwin
Swimming is an important source of physical activity and a life skill to prevent drowning. However, little research has been conducted to understand predictors of swimming ability. The purpose of this study was to understand factors that predict swimming ability among children and adolescents in the United States (US). This was a cross-sectional survey conducted between February and April of 2017 across five geographically diverse cities. Participants were accessed through the Young Christian Men's Association (YMCA) and included parents of children aged 4⁻11 years old and adolescents aged 12⁻17 years old...
February 24, 2018: Sports
https://www.readbyqxmd.com/read/29908175/young-patients-with-sporadic-colorectal-adenomas-current-endoscopic-surveillance-practices-and-outcomes
#10
Jae Myung Cha, Danielle La Selva, Richard A Kozarek, Michael Gluck, Andrew Ross, Otto S Lin
BACKGROUND AND AIMS: For young individuals (<40) without strong family histories that would put them at risk for genetic colorectal cancer syndromes, it is unclear if national Multi-Society Task Force surveillance recommendations apply or if endoscopists follow these guideline recommendations when such patients are incidentally found to have adenoma(s) on colonoscopy. METHODS: We reviewed records on young (<40-year-old) patients, with either no family history or only a "moderate" family history (one first-degree family member with colorectal cancer at age ≥50), who were found to have neoplastic polyp(s) on their index colonoscopy...
June 13, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29908079/targeted-brain-proteomics-uncover-multiple-pathways-to-alzheimer-s-dementia
#11
Lei Yu, Vladislav A Petyuk, Chris Gaiteri, Sara Mostafavi, Tracy Young-Pearse, Raj C Shah, Aron S Buchman, Julie A Schneider, Paul D Piehowski, Ryan L Sontag, Thomas L Fillmore, Tujin Shi, Richard D Smith, Philip L De Jager, David A Bennett
OBJECTIVE: Previous gene expression analysis identified a network of co-expressed genes that is associated with β-amyloid neuropathology and cognitive decline in older adults. The current work targeted influential genes in this network with quantitative proteomics to identify potential novel therapeutic targets. METHODS: Data came from 834 community-based older persons who were followed annually, died and underwent brain autopsy. Uniform structured postmortem evaluations assessed the burden of β-amyloid and other common age-related neuropathologies...
June 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29907699/decline-in-kidney-function-among-apparently-healthy-young-adults-at-risk-of-mesoamerican-nephropathy
#12
Marvin Gonzalez-Quiroz, Evangelia-Theano Smpokou, Richard J Silverwood, Armando Camacho, Dorien Faber, Brenda La Rosa Garcia, Amin Oomatia, Michael Hill, Jason Glaser, Jennifer Le Blond, Catharina Wesseling, Aurora Aragon, Liam Smeeth, Neil Pearce, Dorothea Nitsch, Ben Caplin
Background Epidemic levels of CKD of undetermined cause, termed Mesoamerican nephropathy in Central America, have been found in low- and middle-income countries. We investigated the natural history of, and factors associated with, loss of kidney function in a population at high risk for this disease. Methods We conducted a 2-year prospective, longitudinal study with follow-up every 6 months in nine rural communities in northwestern Nicaragua and included all men ( n =263) and a random sample of women ( n =87) ages 18-30 years old without self-reported CKD, diabetes, or hypertension...
June 15, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29906005/adult-onset-papular-purpuric-gloves-and-socks-syndrome
#13
Monica Rosales Santillan, Jessica B Dietert, Richard Jahan-Tigh
Papular purpuric gloves and socks syndrome (PPGSS) is a self-limited exanthem that presents as painful or pruritic edema, erythema, petechiae, and purpura of the palms and soles with occasional extension to the dorsal hands and feet. The majority of PPGSS cases reported in the literature are associated with parvovirus B19 and occur in children and young adults. In a recent literature search, there were 11 PPGSS cases in adults with none reporting Epstein-Barr virus (EBV) as a viral etiology. However, there have been PPGSS cases related to EBV in children...
April 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29905584/human-papilloma-virus-and-the-nurse-s-role-in-education-and-prevention
#14
Jennifer S Sherry, Sandra K Collins, Richard C McKinnies, Anthony Fleege, Marcea L Walter
In the United States, an estimated 20 million people, or 15% of the population, are currently infected with human papilloma virus (HPV). The prevalence of HPV is increasing in females aged 14 to 24 years. Assessing allied health students' knowledge, attitudes, and behaviors regarding HPV was performed using a 34-question survey. The survey was in four sections: general information, measuring knowledge of HPV and the vaccine, HPV vaccine, and HPV screening and diagnosis. Physicians were noted by 31.6% of the participants as the first individual who gave them information about HPV...
June 14, 2018: Health Care Manager
https://www.readbyqxmd.com/read/29905301/egd-core-curriculum
#15
Richard S Kwon, Raquel E Davila, Daniel K Mullady, Mohammad A Al-Haddad, Ji Young Bang, Juliane Bingener-Casey, Brian P Bosworth, Jennifer A Christie, Gregory A Cote, Sarah Diamond, Jennifer Jorgensen, Thomas E Kowalski, Nisa Kubiliun, Joanna K Law, Keith L Obstein, Waqar A Qureshi, Francisco C Ramirez, Robert E Sedlack, Franklin Tsai, Shivakumar Vignesh, Mihir S Wagh, Daniel Zanchetti, Walter J Coyle, Jonathan Cohen
No abstract text is available yet for this article.
July 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29902162/youth-risk-behavior-surveillance-united-states-2017
#16
Laura Kann, Tim McManus, William A Harris, Shari L Shanklin, Katherine H Flint, Barbara Queen, Richard Lowry, David Chyen, Lisa Whittle, Jemekia Thornton, Connie Lim, Denise Bradford, Yoshimi Yamakawa, Michelle Leon, Nancy Brener, Kathleen A Ethier
PROBLEM: Health-risk behaviors contribute to the leading causes of morbidity and mortality among youth and adults in the United States. In addition, significant health disparities exist among demographic subgroups of youth defined by sex, race/ethnicity, and grade in school and between sexual minority and nonsexual minority youth. Population-based data on the most important health-related behaviors at the national, state, and local levels can be used to help monitor the effectiveness of public health interventions designed to protect and promote the health of youth at the national, state, and local levels...
June 15, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29898988/age-correlates-with-response-to-anti-pd1-reflecting-age-related-differences-in-intratumoral-effector-and-regulatory-t-cell-populations
#17
Curtis H Kugel, Stephen M Douglass, Marie R Webster, Amanpreet Kaur, Qin Liu, Xiangfan Yin, Sarah A Weiss, Farbod Darvishian, Rami N Al-Rohil, Abibatou Ndoye, Reeti Behera, Gretchen M Alicea, Brett L Ecker, Mitchell Fane, Michael J Allegrezza, Nikolaos Svoronos, Vinit Kumar, Daniel Y Wang, Rajasekharan Somasundaram, Siwen Hu-Lieskovan, Alpaslan Ozgun, Meenhard Herlyn, Jose R Conejo-Garcia, Dmitry Gabrilovich, Erica L Stone, Theodore S Nowicki, Jeffrey Sosman, Rajat Rai, Matteo S Carlino, Georgina V Long, Richard Marais, Antoni Ribas, Zeynep Eroglu, Michael A Davies, Bastian Schilling, Dirk Schadendorf, Wei Xu, Ravi K Amaravadi, Alexander M Menzies, Jennifer L McQuade, Douglas B Johnson, Iman Osman, Ashani T Weeraratna
Purpose: We have shown that the aged microenvironment increases melanoma metastasis, and decreases response to targeted therapy, and here we queried response to anti-PD1. Experimental Design: We analyzed the relationship between age, response to anti-PD1, and prior therapy in 538 patients. We used mouse models of melanoma, to analyze the intratumoral immune microenvironment in young versus aged mice and confirmed our findings in human melanoma biopsies. Results: Patients over the age of 60 responded more efficiently to anti-PD-1, and likelihood of response to anti-PD-1 increased with age, even when we controlled for prior MAPKi therapy...
June 13, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29898835/comparison-of-automated-interval-measurements-by-widely-used-algorithms-in-digital-electrocardiographs
#18
Paul Kligfield, Fabio Badilini, Isabelle Denjoy, Saeed Babaeizadeh, Elaine Clark, Johan De Bie, Brian Devine, Fabrice Extramiana, Gianluca Generali, Richard Gregg, Eric Helfenbein, Jan Kors, Remo Leber, Peter Macfarlane, Pierre Maison-Blanche, Ian Rowlandson, Ramun Schmid, Martino Vaglio, Gerard van Herpen, Joel Xue, Brian Young, Cynthia L Green
BACKGROUND: Automated measurements of electrocardiographic (ECG) intervals by current-generation digital electrocardiographs are critical to computer-based ECG diagnostic statements, to serial comparison of ECGs, and to epidemiological studies of ECG findings in populations. A previous study demonstrated generally small but often significant systematic differences among 4 algorithms widely used for automated ECG in the United States and that measurement differences could be related to the degree of abnormality of the underlying tracing...
June 2018: American Heart Journal
https://www.readbyqxmd.com/read/29889563/longitudinal-association-between-peer-victimization-and-sleep-problems-in-preschoolers-the-moderating-role-of-parenting
#19
François Bilodeau, Mara Brendgen, Frank Vitaro, Sylvana M Côté, Richard E Tremblay, Evelyne Touchette, Jacques Montplaisir, Michel Boivin
This study examined the moderating role of parental behaviors in the longitudinal link between peer victimization and sleep problems during preschool. The sample consisted of 1,181 children (594 girls) attending day care between the ages of 3 and 6 years. Participants were part of the Quebec Longitudinal Study of Child Development, a longitudinal study of child development led by the Institut de la Statistique du Quebec. Controlling for potential confounders, latent growth curve analyses revealed that the association between peer victimization and sleep problems varied depending on parents' behaviors...
June 11, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29888019/thoracic-empyema-as-rare-complication-of-an-appendicular-mass-a-case-study-and-review-of-the-literature
#20
George Vasquez-Rios, Lesly Calixto-Aguilar, Richard Pajuelo, Wilder Alarcon
Introduction: Thoracic empyema is an infrequent complication of appendicitis that has rarely been reported in the literature. Case Presentation and Review of the Literature: The case of a 11-year-old boy who was admitted for medical management of an appendicular mass is presented. His clinical course was complicated by the development of an appendicular abscess and an extensive right-sided empyema. A comprehensive review of the literature was conducted including the most representative cases...
2018: Case Reports in Pediatrics
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