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https://www.readbyqxmd.com/read/29445269/an-open-label-prospective-interventional-study-of-the-tolerability-and-efficacy-of-0-4-mg-oral-tamsulosin-oral-controlled-absorption-system-in-men-with-lower-urinary-tract-symptoms-associated-with-benign-prostatic-hyperplasia-who-are-unsatisfied-with-treatment
#1
Pei-Shan Yang, Chien-Lun Chen, Chen-Pang Hou, Yu-Hsiang Lin, Ke-Hung Tsui
Purpose: The aim of this study was to investigate the efficacy and tolerability of switching from 0.2 mg tamsulosin to 0.4 mg tamsulosin oral controlled absorption system (OCAS) over a 12-week period in Taiwanese men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Patients and methods: Taiwanese male patients who were dissatisfied with treatment with 0.2 mg tamsulosin were enrolled in this clinical study and switched to 0...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29437493/identification-of-five-novel-variants-in-chinese-oculocutaneous-albinism-by-targeted-next-generation-sequencing
#2
Biyuan Qiu, Tao Ma, Chunyan Peng, Xiaoqin Zheng, Jiyun Yang
BACKGROUND: The diagnosis of oculocutaneous albinism (OCA) is established using clinical signs and symptoms. OCA is, however, a highly genetically heterogeneous disease with mutations identified in at least nineteen unique genes, many of which produce overlapping phenotypic traits. Thus, differentiating genetic OCA subtypes for diagnoses and genetic counseling is challenging, based on clinical presentation alone, and would benefit from a comprehensive molecular diagnostic. AIM: To develop and validate a more comprehensive, targeted, next-generation-sequencing-based diagnostic for the identification of OCA-causing variants...
February 13, 2018: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29433200/relationship-between-nano-micro-structure-and-physical-properties-of-tio2-sodium-caseinate-composite-films
#3
Juan Manuel Montes-de-Oca-Ávalos, Davide Altamura, Roberto Jorge Candal, Francesco Scattarella, Dritan Siliqi, Cinzia Giannini, María Lidia Herrera
Films obtained by casting, starting from conventional emulsions (CE), nanoemulsions (NE) or their gels, which led to different structures, with the aim of explore the relationship between structure and physical properties, were prepared. Sodium caseinate was used as the matrix, glycerol as plasticizer, glucono-delta-lactone as acidulant to form the gels, and TiO2 nanoparticles as reinforcement to improve physical behavior. Structural characterization was performed by SAXS and WAXS (Small and Wide Angle X-ray Scattering, respectively), combined with confocal and scanning electron microscopy...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29429520/osteogenesis-induced-by-a-three-dimensional-bioimplant-composed-of-demineralised-bone-matrix-collagen-hydroxyapatite-and-bone-marrow-derived-cells-in-massive-bone-defects-an-experimental-study
#4
Carlos E Cuervo-Lozano, Adolfo Soto-Domínguez, Odila Saucedo-Cárdenas, Roberto Montes-de-Oca-Luna, Sergio Alonso-Romero, María Del Consuelo Mancías-Guerra, Eduardo Álvarez-Lozano
Treatment of massive bone defects is one of the most difficult problems to solve in orthopedics. At present, there is no consensus on the best way to resolve these problems. The aim of our study was to evaluate the effect of a three-dimensional bioimplant over massive bone defects, and to analyse if it improves the speed and quality of integration in recipient bone compared to allograft treatment. Fifteen female lambs with massive bone defects, surgically created in their tibias, were randomly divided into three groups of five lambs each: Group I -treated with the bioimplant; Group 2 -treated with the bioimplant plus nucleated cells of autologous bone marrow; Group 3 -treated with a frozen allograft...
February 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29424234/osteochondral-allograft-transplantation-of-the-knee-in-patients-with-an-elevated-body-mass-index
#5
Dean Wang, Brian J Rebolledo, David M Dare, Mollyann D Pais, Matthew R Cohn, Kristofer J Jones, Riley J Williams
Objective To characterize the graft survivorship and clinical outcomes of osteochondral allograft transplantation (OCA) of the knee in patients with an elevated body mass index (BMI). Design Prospective data on 38 consecutive patients with a BMI ≥30 kg/m2 treated with OCA from 2000 to 2015 were reviewed. Complications, reoperations, and patient responses to validated outcome measures were examined. Failures were defined by any removal/revision of the allograft or conversion to arthroplasty. Results Thirty-one knees in 31 patients (mean age, 35...
February 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29422071/prevalence-and-outcome-of-patients-with-non-st-segment-elevation-myocardial-infarction-with-occluded-culprit-artery-a-systemic-review-and-meta-analysis
#6
Chi-Sheng Hung, Ying-Hsien Chen, Ching-Chang Huang, Mao-Shin Lin, Chih-Fan Yeh, Hung-Yuan Li, Hsien-Li Kao
BACKGROUND: The aim was to determine the prevalence and impact of an occluded "culprit" artery (OCA) in patients with non-ST segment elevation myocardial infarction (NSTEMI). METHODS: We searched PubMed, EMBASE, and Web of Science, with no language restrictions, up to 1 Jul. 2016. Observational cohorts or clinical trials of adult NSTEMI were eligible for inclusion to determine the prevalence if the proportion of OCA on coronary angiography was reported. Studies were further eligible for inclusion to determine the outcome if the association between OCA and clinical endpoints was reported...
February 9, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29413510/prevalence-and-impact-of-respiratory-symptoms-in-a-population-of-patients-with-copd-in-latin-america-the-lassyc-observational-study
#7
Marc Miravitlles, Ana Menezes, Maria Victorina López Varela, Alejandro Casas, Luis Ugalde, Alejandra Ramirez-Venegas, Laura Mendoza, Ana López, Fernando C Wehrmeister, Filip Surmont, Maria Montes de Oca
BACKGROUND: To analyse the relationship between symptoms at different times during the 24-hour day and outcomes in COPD. METHODS: Observational cross-sectional study in a patients from 7 Latin American countries. The frequency of symptoms in the morning, at night and during the day was explored by means of standardised and validated questionnaires, and the relationship between symptoms and exacerbations and quality of life were investigated. RESULTS: 734 patients (59...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29388837/adenovirus-lacking-e1b-efficiently-induces-cytopathic-effect-in-hpv-16-positive-murine-cancer-cells-via-virus-replication-and-apoptosis
#8
Elvis Martinez-Jaramillo, Rodolfo Garza-Morales, Stephen L Wechman, Roberto Montes de Oca-Luna, Odila Saucedo-Cardenas, Haval Shirwan, Esma Yolcu, Kelly M McMasters, Jorge G Gomez-Gutierrez
Conditionally replicative adenoviruses (CRAds) replicate poorly in murine cancer cells; however, E1b-deleted CRAds may replicate effectively in HPV16-E6/E7-positive murine cancer cells (TC-1). The HPV16 E7 open reading frame encodes functions analogous to these deleted adenovirus E1 proteins. In this study, an E1b-deleted CRAd (Adhz60) was evaluated for its ability to replicate and induce oncolysis in TC-1 cells. Adhz60-mediated oncolysis was similar in TC-1 and HeLa cells. Productive viral replication was evident based on expression of E1A and hexon, production of infectious virus progeny, and Adhz60-induced apoptosis...
February 1, 2018: Cancer Investigation
https://www.readbyqxmd.com/read/29377414/optical-clearing-agent-reduces-scattering-of-light-by-the-stratum-corneum-and-modulates-the-physical-properties-of-coenocytes-via-hydration
#9
S-H Lee, S-H Jun, J Yeom, S-G Park, C-K Lee, N-G Kang
BACKGROUND: The interaction between light and the skin determine how the skin looks to the human eye. Light can be absorbed, scattered, and reflected by different components of the skin in a variety of different ways. Here, we focus on the scattering properties of the outmost layer, the stratum corneum (SC). However, we currently have limited methods with which to distinguish the scattering of light by SC from the changes due to other components of the skin. MATERIALS AND METHODS: Dark-field images of tape-striped corneocytes were used in vitro to study the differences in light scattered by the SC and other skin components...
January 28, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29375205/int-767-improves-histopathological-features-in-a-diet-induced-ob-ob-mouse-model-of-biopsy-confirmed-non-alcoholic-steatohepatitis
#10
Jonathan D Roth, Michael Feigh, Sanne S Veidal, Louise Kd Fensholdt, Kristoffer T Rigbolt, Henrik H Hansen, Li C Chen, Mathieu Petitjean, Weslyn Friley, Niels Vrang, Jacob Jelsing, Mark Young
AIM: To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis (NASH). METHODS: The effects of INT-767 on histological features of NASH were assessed in two studies using Lepob/ob (ob/ob) NASH mice fed the AMLN diet (high fat with trans-fat, cholesterol and fructose). In a proof-of-concept study, Lepob/ob (ob/ob) NASH mice were first dosed with INT-767 (3 or 10 mg/kg for 8 wk)...
January 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29375204/metabolic-and-hepatic-effects-of-liraglutide-obeticholic-acid-and-elafibranor-in-diet-induced-obese-mouse-models-of-biopsy-confirmed-nonalcoholic-steatohepatitis
#11
Kirstine S Tølbøl, Maria Nb Kristiansen, Henrik H Hansen, Sanne S Veidal, Kristoffer Tg Rigbolt, Matthew P Gillum, Jacob Jelsing, Niels Vrang, Michael Feigh
AIM: To evaluate the pharmacodynamics of compounds in clinical development for nonalcoholic steatohepatitis (NASH) in obese mouse models of biopsy-confirmed NASH. METHODS: Male wild-type C57BL/6J mice (DIO-NASH) and Lep ob/ob (ob/ob-NASH) mice were fed a diet high in trans-fat (40%), fructose (20%) and cholesterol (2%) for 30 and 21 wk, respectively. Prior to treatment, all mice underwent liver biopsy for confirmation and stratification of liver steatosis and fibrosis, using the nonalcoholic fatty liver disease activity score (NAS) and fibrosis staging system...
January 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29366342/long-term-follow-up-of-revision-osteochondral-allograft-transplantation-of-the-ankle
#12
Florian Gaul, Luís E P Tírico, Julie C McCauley, William D Bugbee
BACKGROUND: Osteochondral allograft (OCA) transplantation is a useful alternative for treatment of posttraumatic ankle arthritis in young patients but has a relatively high failure rate and further procedures are often required. The purpose of this study was to evaluate outcomes of patients who underwent revision OCA transplantation of the ankle after failed primary OCA transplantation. METHODS: Twenty patients underwent revision OCA transplantation of the ankle between 1988 and 2015...
January 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29360386/lesion-size-does-not-predict-outcomes-in-fresh-osteochondral-allograft-transplantation
#13
Luis E P Tírico, Julie C McCauley, Pamela A Pulido, William D Bugbee
BACKGROUND: Cartilage repair algorithms use lesion size to choose surgical techniques when selecting a cartilage repair procedure. The association of fresh osteochondral allograft (OCA) size with graft survivorship and subjective patient outcomes is still unknown. PURPOSE: To determine if lesion size (absolute or relative) affects outcomes after OCA transplantation. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: The study included 156 knees in 143 patients who underwent OCA transplantation from 1998 to 2014 for isolated femoral condyle lesions...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29354476/meniscal-allograft-transplantation-with-concomitant-osteochondral-allograft-transplantation
#14
Eric J Cotter, Rachel M Frank, Brian R Waterman, Kevin C Wang, Michael L Redondo, Brian J Cole
Surgical strategies for knee joint preservation are numerous, with the procedure(s) of choice for a given patient dependent on the status of the articular cartilage, meniscus, overall alignment, and ligamentous stability. For patients with large, isolated, osteochondral defects of the articular cartilage of the femoral condyle, osteochondral allograft transplantation (OCA) is often performed in an effort to reduce pain and improve function. Similarly, for appropriately indicated patients with symptomatic meniscus deficiency, meniscus allograft transplantation (MAT) is an excellent surgical solution...
October 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29354455/fresh-osteochondral-allograft-transplantation-for-focal-chondral-defect-of-the-humerus-associated-with-anchor-arthropathy-and-failed-slap-repair
#15
Kevin C Wang, Brian R Waterman, Eric J Cotter, Rachel M Frank, Brian J Cole
Isolated, full-thickness articular cartilage lesions of the glenohumeral joint can cause pain, mechanical symptoms, and impaired function. Reports on operative management of these injuries with arthroscopic techniques, such as marrow stimulation, have shown improvement in patient symptoms. In cases where the subchondral bone is involved, osteochondral allograft (OCA) transplantation has shown positive results for contained, focal cartilage defects. The technique for OCA transplantation to treat Hill-Sachs lesions has been reported in detail, and there are multiple case series reporting on the outcomes of OCA used for this purpose...
August 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29346429/the-farnesoid-x-receptor-agonist-obeticholic-acid-upregulates-biliary-excretion-of-asymmetric-dimethylarginine-via-mate-1-during-hepatic-ischemia-reperfusion-injury
#16
Andrea Ferrigno, Laura Giuseppina Di Pasqua, Clarissa Berardo, Veronica Siciliano, Vittoria Rizzo, Luciano Adorini, Plinio Richelmi, Mariapia Vairetti
BACKGROUND: We previously showed that increased asymmetric dimethylarginine (ADMA) biliary excretion occurs during hepatic ischemia/reperfusion (I/R), prompting us to study the effects of the farnesoid X receptor (FXR) agonist obeticholic acid (OCA) on bile, serum and tissue levels of ADMA after I/R. MATERIAL AND METHODS: Male Wistar rats were orally administered 10mg/kg/day of OCA or vehicle for 5 days and were subjected to 60 min partial hepatic ischemia or sham-operated...
2018: PloS One
https://www.readbyqxmd.com/read/29334769/topographic-analysis-of-the-distal-femoral-condyle-articular-cartilage-surface-adequacy-of-the-graft-from-opposite-condyles-of-the-same-or-different-size-for-the-osteochondral-allograft-transplantation
#17
Adam B Yanke, Atsushi Urita, Jason J Shin, Greg L Cvetanovich, Erin K Moran, Bernard R Bach, Brian J Cole, Nozomu Inoue, Nikhil N Verma
Objective To analyze the topography of the opposite condyle to treat focal femoral condyle articular defects with an osteochondral allograft (OCA). Design Three groups were created: Group 1, same condyle with same width; Group 2, opposite condyle with same width; Group 3, opposite condyle with different width. Computed tomography (CT) of 22 cadaveric femoral hemi-condyles was used to create 3-dimensional CT models that were exported into point-cloud models. Three zones of the donor condyle (anterior, middle, and posterior) were quantified...
January 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29333665/clinical-and-metabolic-effects-associated-with-weight-changes-and-obeticholic-acid-in-non-alcoholic-steatohepatitis
#18
B Hameed, N A Terrault, R M Gill, R Loomba, N Chalasani, J H Hoofnagle, M L Van Natta
BACKGROUND: In a 72-week, randomised controlled trial of obeticholic acid (OCA) in non-alcoholic steatohepatitis (NASH), OCA was superior to placebo in improving serum ALT levels and liver histology. OCA therapy also reduced weight. AIMS: Because weight loss by itself can improve histology, to perform a post hoc analysis of the effects of weight loss and OCA treatment in improving clinical and metabolic features of NASH. METHODS: The analysis was limited to the 200 patients with baseline and end-of-treatment liver biopsies...
January 14, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29329390/human-oocyte-calcium-analysis-predicts-the-response-to-assisted-oocyte-activation-in-patients-experiencing-fertilization-failure-after-icsi
#19
M Ferrer-Buitrago, L Dhaenens, Y Lu, D Bonte, F Vanden Meerschaut, P De Sutter, L Leybaert, B Heindryckx
STUDY QUESTION: Can human oocyte calcium analysis predict fertilization success after assisted oocyte activation (AOA) in patients experiencing fertilization failure after ICSI? SUMMARY ANSWER: ICSI-AOA restores the fertilization rate only in patients displaying abnormal Ca2+ oscillations during human oocyte activation. WHAT IS KNOWN ALREADY: Patients capable of activating mouse oocytes and who showed abnormal Ca2+ profiles after mouse oocyte Ca2+ analysis (M-OCA), have variable responses to ICSI-AOA...
January 10, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29314864/outcomes-of-osteochondral-allograft-transplantation-with-and-without-concomitant-meniscus-allograft-transplantation-a-comparative-matched-group-analysis
#20
Rachel M Frank, Simon Lee, Eric J Cotter, Charles P Hannon, Timothy Leroux, Brian J Cole
BACKGROUND: Osteochondral allograft transplantation (OCA) is often performed with concomitant meniscus allograft transplantation (MAT) as a strategy for knee joint preservation, although to date, the effect of concomitant MAT on outcomes and failure rates after OCA has not been assessed. PURPOSE: To determine clinical outcomes for patients undergoing OCA with MAT as compared with a matched cohort of patients undergoing isolated OCA. STUDY DESIGN: Control study; Level of evidence, 3...
January 1, 2018: American Journal of Sports Medicine
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