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https://www.readbyqxmd.com/read/29681937/sheehan-s-syndrome-revisited-underlying-autoimmunity-or-hypoperfusion
#1
José Gerardo González-González, Omar David Borjas-Almaguer, Alejandro Salcido-Montenegro, René Rodríguez-Guajardo, Anasofia Elizondo-Plazas, Roberto Montes-de-Oca-Luna, René Rodríguez-Gutiérrez
Sheehan's syndrome remains a frequent obstetric complication with an uncertain pathophysiology. We aimed to assess the incidence of hypopituitarism (≥2 hormonal axis impairment) within the first six postchildbirth months and to determine the existence of anti-pituitary antibodies. From 2015 to 2017, adult pregnant women, who developed moderate to severe postpartum hemorrhage (PPH), were consecutively included in the study. Pituitary function was assessed 4 and 24 weeks after PPH. At the end of the study, anti-pituitary antibodies were assessed...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29675506/large-osteochondral-allografts-of-the-knee-surgical-technique-and-indications
#2
REVIEW
Gabriele Pisanu, Umberto Cottino, Federica Rosso, Davide Blonna, Antonio Giulio Marmotti, Corrado Bertolo, Roberto Rossi, Davide E Bonasia
Large osteochondral allograft (OCA) transplant has become a valid alternative to restore articular surface in challenging articular lesions in young and active patients, either in primary or in revision procedures. Several studies support the effectiveness and safety of OCA, but costs and graft availability limit their use. The indications are the treatment of symptomatic full-thickness cartilage lesions greater than 3 cm 2 , deep lesions with subchondral damage, or revision procedures when a previous treatment has failed...
March 2018: Joints
https://www.readbyqxmd.com/read/29674877/a-new-species-of-knob-scaled-lizard-xenosauridae-xenosaurus-from-the-sierra-madre-oriental-of-puebla-mexico
#3
Adrián Nieto-Montes de Oca, Helder Sánchez-Vega, Itzel Durán-Fuentes
A new species of Xenosaurus in the X. tzacualtipantecus clade is described from the Sierra Madre Oriental of northern Puebla, Mexico. The new species differs from all of its congeners in possessing a unique combination of characters. The new species appears to be allopatric and fills in the geographic gap between the geographic distributions of X. tzacualtipantecus and the species in the newmanorum clade to the north and northwest and those of the species in the grandis and rackhami clades to the south and southeast...
2018: ZooKeys
https://www.readbyqxmd.com/read/29669383/total-knee-arthroplasty-versus-osteochondral-allograft-prevalence-and-risk-factors-following-tibial-plateau-fractures
#4
Lasun O Oladeji, Tina K Dreger, Eli L Pratte, Charles A Baumann, James P Stannard, David A Volgas, Gregory J Della Rocca, Brett D Crist
Orthopaedic surgeons commonly have the misconception that patients with tibial plateau fractures will likely go on to posttraumatic knee arthritis requiring total knee arthroplasty (TKA). In younger patients, osteochondral allograft (OCA) transplantation is an alternative method to address posttraumatic knee arthritis. The purpose of this study was (1) to identify our institutional failure rate following tibial plateau open reduction and internal fixation (ORIF) (failure was defined as conversion to TKA or OCA); (2) to determine if there are patient- or injury-related risk factors predictive of failure; and (3) to characterize differences between patients treated with TKA versus those treated with OCA transplantation...
April 18, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29661283/2-octylcyanoacrylate-for-the-prevention-of-anastomotic-leak
#5
Anthony B Costales, Deepa Patil, Anny Mulya, John P Kirwan, Chad M Michener
BACKGROUND: Anastomotic leak after colorectal surgery is a significant cause of morbidity and mortality. The aim of this study was to evaluate the impact of a reinforced colo-colonic anastomosis with tissue adhesive, 2-octylcyanoacrylate (2-OCA), on the integrity of anastomotic healing as measured by anastomotic bursting pressure. METHODS: Sixty-eight female Sprague-Dawley rats underwent a rectosigmoid colon transection and a sutured end-to-end anastomosis followed by randomization to receive no further intervention or reinforcement with the tissue adhesive, 2-OCA...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29660435/yangonin-protects-against-cholestasis-and-hepatotoxity-via-activation-of-farnesoid-x-receptor-in-vivo-and-in-vitro
#6
Xiaoguang Gao, Ting Fu, Changyuan Wang, Chenqing Ning, Kexin Liu, Zhihao Liu, Huijun Sun, Xiaodong Ma, Xiaokui Huo, Xiaobo Yang, Ming Zou, Qiang Meng
Cholestasis is a clinical syndrome with systemic and intrahepatic accumulation of excessive toxic bile acids that ultimately cause hepatobiliary injury. Recently obeticholic acid (OCA) which is a farnesoid X receptor (FXR) agonist was approved by FDA to treat cholestatic liver diseases, which provided us a newly therapeutic strategy against cholestasis. The purpose of the current study is to screen novel FXR agonists and verify the anti-cholestasis effect of yangonin in vivo and in vitro. The computational strategy of two-dimensional virtual screening was used to search for new FXR agonists, and dual-luciferase reporter gene assay was used to further demonstrate FXR activation by yangonin...
April 13, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29658579/identification-of-tyr-mutations-in-patients-with-oculocutaneous-albinism
#7
Wan Sun, Yanjie Shen, Shan Shan, Liyun Han, Yang Li, Zheng Zhou, Zilin Zhong, Jianjun Chen
Oculocutaneous albinism (OCA) is a set of autosomal recessive disorders characterized by hypopigmented hair, skin and eyes. Homozygous or compound heterozygous mutations in the tyrosinase (TYR) gene can cause OCA1, which is the most common and severe subtype of albinism. In the present study, 17 patients with non‑syndromic OCA were enrolled from eight provinces of China and were non‑consanguineous, with the exception of Patient 4000301. Total genomic DNA was isolated from peripheral blood. Screening was performed for the whole exons and their flanking regions of the TYR gene using Sanger sequencing and the pathogenicity of variants was predicted using in silico analysis...
April 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29652896/a-cohort-study-of-the-effects-of-older-adult-care-dependence-upon-household-economic-functioning-in-peru-mexico-and-china
#8
Maëlenn M Guerchet, Mariella Guerra, Yueqin Huang, Peter Lloyd-Sherlock, Ana Luisa Sosa, Richard Uwakwe, Isaac Acosta, Peter Ezeah, Sara Gallardo, Zhaorui Liu, Rosie Mayston, Veronica Montes de Oca, Hong Wang, Martin J Prince
BACKGROUND: While links between disability and poverty are well established, there have been few longitudinal studies to clarify direction of causality, particularly among older adults in low and middle income countries. We aimed to study the effect of care dependence among older adult residents on the economic functioning of their households, in catchment area survey sites in Peru, Mexico and China. METHODS: Households were classified from the evolution of the needs for care of older residents, over two previous community surveys, as 'incident care', 'chronic care' or 'no care', and followed up three years later to ascertain economic outcomes (household income, consumption, economic strain, satisfaction with economic circumstances, healthcare expenditure and residents giving up work or education to care)...
2018: PloS One
https://www.readbyqxmd.com/read/29643296/phylogenetic-relationship-of-ornithobacterium-rhinotracheale-strains
#9
Roberto Montes DE Oca-Jimenez, Vicente Vega-Sanchez, Vladimir Morales-Erasto, Celene Salgado-Miranda, Patrick J Blackall, Edgardo Soriano-Vargas
The bacterium Ornithobacterium rhinotracheale is associated with respiratory disease in wild birds and poultry. In this study, the phylogenetic analysis of nine reference strains of O. rhinotracheale belonging to serovars A to I, and eight Mexican isolates belonging to serovar A, was performed. The analysis was extended to include available sequences from another 23 strains available in the public domain. The analysis showed that the 40 sequences formed six clusters, I to VI. All eight Mexican field isolates were placed in cluster I...
April 10, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29619397/treatment-of-failed-articular-cartilage-reconstructive-procedures-of-the-knee-a-systematic-review
#10
REVIEW
Joseph D Lamplot, Kevin A Schafer, Matthew J Matava
Background: Symptomatic articular cartilage lesions of the knee are common and are being treated surgically with increasing frequency. While many studies have reported outcomes following a variety of cartilage restoration procedures, few have investigated outcomes of revision surgery after a failed attempt at cartilage repair or reconstruction. Purpose: To investigate outcomes of revision cartilage restoration procedures for symptomatic articular cartilage lesions of the knee following a previously failed cartilage reconstructive procedure...
March 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29613978/gonioscopy-assisted-transluminal-trabeculotomy-an-ab-interno-circumferential-trabeculotomy-24-month-follow-up
#11
Davinder S Grover, Oluwatosin Smith, Ronald L Fellman, David G Godfrey, Aditi Gupta, Ildamaris Montes de Oca, William J Feuer
PURPOSE: Provide 24-month follow up on surgical success and safety of an ab interno circumferential 360-degree trabeculotomy. PATIENTS AND METHODS: Chart review of patients who underwent a GATT procedure by 4 of the authors (D.S.G., O.S., R.L.F., D.G.G.). The surgery was performed in adults with various open-angle glaucomas with pre-operative intraocular pressures (IOP) of ≥18▒mm Hg. RESULTS: 198 patients aged 24-89 years underwent the GATT procedure with at least 18 months follow-up...
April 2, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29605282/accuracy-of-8-intraocular-lens-calculation-formulas-in-relation-to-anterior-chamber-depth-in-patients-with-normal-axial-lengths
#12
Sabite Emine Gökce, Ildamaris Montes De Oca, David L Cooke, Li Wang, Douglas D Koch, Zaina Al-Mohtaseb
PURPOSE: To determine the effect of anterior chamber depth (ACD) on the accuracy of 8 intraocular lens calculation formulas in patients with normal axial lengths (ALs). SETTING: Baylor College of Medicine, Alkek Eye center, Houston, Texas, USA. DESIGN: Retrospective case series. METHODS: Patients having cataract surgery with ALs between 22.0 mm and 25.0 mm were divided into 3 groups based on their preoperative ACD measurement...
March 28, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29603207/acquired-ichthyosis-associated-with-gastric-adenocarcinoma
#13
Mariana Saldaña, Griselda Montes de Oca, Andrés Tirado-Sánchez, Patricia Mercadillo, María-Ivonne Arellano-Mendoza
No abstract text is available yet for this article.
March 30, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29600684/-current-advances-on-surgical-treatment-for-knee-articular-cartilage-injuries
#14
REVIEW
Long Xin, Chun Zhang, Wei-Xing Xu, Fu-Hua Zhong, Shun-Wu Fan, Zhen-Bin Wang
Chondral injuries are short of self-healing ability and need to surgical repair after articular cartilage injury. Conventional treatment includes debridement and drainage under arthroscope, micro-fracture, osteochondral autograft transplantation (OATS), mosaiplasty and osteochondral allografts (OCA), autologous chondrocyte implantation (ACI). Debridement and drainage could remove pain factor, and has advantages of simple operation, wide clinical application and early clinical effect. Micro-fracture and osteochondral autograft transplantation is suitable for small area of cartilage repair, while the further effect showed that fibrous cartilage permeated by drill could decrease postoperative clinical effect...
March 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29593060/the-british-society-of-gastroenterology-uk-pbc-primary-biliary-cholangitis-treatment-and-management-guidelines
#15
Gideon M Hirschfield, Jessica K Dyson, Graeme J M Alexander, Michael H Chapman, Jane Collier, Stefan Hübscher, Imran Patanwala, Stephen P Pereira, Collette Thain, Douglas Thorburn, Dina Tiniakos, Martine Walmsley, George Webster, David E J Jones
Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury, cholestasis and progressive fibrosis can culminate over time in an end-stage biliary cirrhosis. Both genetic and environmental influences are presumed relevant to disease initiation. PBC is most prevalent in women and those over the age of 50, but a spectrum of disease is recognised in adult patients globally; male sex, younger age at onset (<45) and advanced disease at presentation are baseline predictors of poorer outcome...
March 28, 2018: Gut
https://www.readbyqxmd.com/read/29559521/fxr-activation-by-obeticholic-acid-or-non-steroidal-agonists-induces-a-human-like-lipoprotein-cholesterol-change-in-mice-with-humanized-chimeric-liver
#16
Romeo Papazyan, Xueqing Liu, Jingwen Liu, Bin Dong, Emily M Plummer, Ronald D Lewis, Jonathan D Roth, Mark A Young
Obeticholic acid (OCA) is a selective farnesoid X receptor (FXR) agonist that regulates bile acid and lipid metabolism. FXR activation induces distinct changes in circulating cholesterol among animal models and humans. The mechanistic basis of these effects has been elusive because of difficulties in studying lipoprotein homeostasis in mice, which predominantly package circulating cholesterol in high-density lipoproteins. Here, we tested the effects of OCA in chimeric mice whose livers are mostly composed (≥80%) of human hepatocytes...
March 20, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29528060/insights-into-the-interfacial-strengthening-mechanisms-of-calcium-silicate-hydrate-polymer-nanocomposites
#17
Yang Zhou, Dongshuai Hou, Guoqing Geng, Pan Feng, Jiao Yu, Jinyang Jiang
The mechanical properties of organic/inorganic composites can be highly dependent on the interfacial interactions. In this work, with organic polymers intercalated into the interlayer of inorganic calcium silicate hydrate (C-S-H), the primary binding phase of Portland cement, great ductility improvement is obtained for the nanocomposites. Employing reactive molecular dynamics, the simulation results indicate that strong interfacial interactions between the polymers and the substrate contribute greatly to strengthening the materials, when C-S-H/poly ethylene glycol (PEG), C-S-H/poly acrylic acid (PAA), and C-S-H/poly vinyl alcohol (PVA) were subject to uniaxial tension along different lattice directions...
March 12, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29514363/comparison-of-techniques-for-preimplantation-treatment-of-osteochondral-allograft-bone
#18
Charles A Baumann, John R Baumann, Chantelle C Bozynski, Aaron M Stoker, James P Stannard, James L Cook
Articular defects are a major problem with few effective treatment options. Osteochondral allograft (OCA) transplantation can be an effective treatment; however, lack of OCA bone integration can cause failure. This controlled laboratory study was designed to compare clinically applicable methods for marrow element removal and enhanced delivery of bone marrow aspirate concentrate (BMC) to OCA bone. We hypothesized that compressed carbon dioxide (CO2 ) treatment of OCA bone would result in significantly better marrow element removal, significantly more retention and distribution of viable osteoprogenitor cells, and significantly higher osteoinductive protein elution from OCAs compared with other preimplantation treatments...
March 7, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29496086/quantitative-computed-tomography-applied-to-interstitial-lung-diseases
#19
Martin Obert, Marian Kampschulte, Rebekka Limburg, Stefan Barańczuk, Gabriele A Krombach
OBJECTIVES: To evaluate a new image marker that retrieves information from computed tomography (CT) density histograms, with respect to classification properties between different lung parenchyma groups. Furthermore, to conduct a comparison of the new image marker with conventional markers. MATERIALS AND METHODS: Density histograms from 220 different subjects (normal = 71; emphysema = 73; fibrotic = 76) were used to compare the conventionally applied emphysema index (EI), 15th percentile value (PV), mean value (MV), variance (V), skewness (S), kurtosis (K), with a new histogram's functional shape (HFS) method...
March 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29487110/fxr-agonists-obeticholic-acid-and-chenodeoxycholic-acid-increase-bile-acid-efflux-in-sandwich-cultured-human-hepatocytes-functional-evidence-and-mechanisms
#20
Cen Guo, Carl LaCerte, Jeffrey E Edwards, Kenneth R Brouwer, Kim L R Brouwer
Farnesoid X Receptor (FXR) is a nuclear receptor that regulates genes involved in bile acid homeostasis. FXR agonists, obeticholic acid (OCA) and chenodeoxycholic acid (CDCA), increase mRNA expression of efflux transporters in sandwich-cultured human hepatocytes (SCHH). This study evaluated the effects of OCA and CDCA treatment on the uptake, basolateral efflux, and biliary excretion of a model bile acid, taurocholate (TCA), in SCHH. Additionally, changes in the protein expression of TCA uptake and efflux transporters were investigated...
February 27, 2018: Journal of Pharmacology and Experimental Therapeutics
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