Natsuda Navamajiti, Apolonia Gardner, Ruonan Cao, Yutaro Sugimoto, Jee Won Yang, Aaron Lopes, Nhi V Phan, Joy Collins, Tiffany Hua, Siriporn Damrongsakkul, Sorada Kanokpanont, Christoph Steiger, Daniel Reker, Robert Langer, Giovanni Traverso
Triggerable coatings, such as pH-responsive polymethacrylate copolymers, can be used to protect the active pharmaceutical ingredients contained within oral solid dosage forms from the acidic gastric environment and to facilitate drug delivery directly to the intestine. However, gastrointestinal pH can be highly variable, which can reduce delivery efficiency when using pH-responsive drug delivery technologies. We hypothesized that biomaterials susceptible to proteolysis could be used in combination with other triggerable polymers to develop novel enteric coatings...
September 8, 2023: Journal of Pharmaceutical Sciences