keyword
MENU ▼
Read by QxMD icon Read
search

Young RA

keyword
https://www.readbyqxmd.com/read/27914133/lobeglitazone-a-novel-thiazolidinedione-improves-non-alcoholic-fatty-liver-disease-in-type-2-diabetes-its-efficacy-and-predictive-factors-related-to-responsiveness
#1
Yong Ho Lee, Jae Hyeon Kim, So Ra Kim, Heung Yong Jin, Eun Jung Rhee, Young Min Cho, Byung Wan Lee
Despite the rapidly increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes (T2D), few treatment modalities are currently available. We investigated the hepatic effects of the novel thiazolidinedione (TZDs), lobeglitazone (Duvie) in T2D patients with NAFLD. We recruited drug-naïve or metformin-treated T2D patients with NAFLD to conduct a multicenter, prospective, open-label, exploratory clinical trial. Transient liver elastography (Fibroscan®; Echosens, Paris, France) with controlled attenuation parameter (CAP) was used to non-invasively quantify hepatic fat contents...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27913060/outcome-of-pregnancy-and-neonatal-complications-with-anti-tumor-necrosis-factor-%C3%AE-use-in-females-with-immune-mediated-diseases-a-systematic-review-and-meta-analysis
#2
REVIEW
Fukiko Komaki, Yuga Komaki, Dejan Micic, Akio Ido, Atsushi Sakuraba
BACKGROUND: Immune mediated diseases such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), and inflammatory bowel disease (IBD) commonly affect young and adolescent females. Anti-tumor necrosis factor (TNF)-α agents are increasingly used to treat these conditions, but their safety during pregnancy remains unclear. OBJECTIVES: To evaluate the risk of pregnancy related outcomes in patients with various immune mediated diseases treated with anti-TNF-α agents...
November 29, 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27904854/legal-issues-related-to-postoperative-pulmonary-thromboembolism-in-korea
#3
Bo Young Park, Min Ji Kim, So Ra Kang, Seung Eun Hong
PURPOSE: Currently, development of pulmonary thromboembolism (PTE) after surgery is frequently being followed by legal action in Korea, as consequences may be fatal. In the current study, we assessed possible countermeasures that medical teams can take when faced with conflicting opinions on responsibility for PTE. METHODS: A retrospective analysis of claims handled by the Supreme Court and subordinate courts, from 1999 to 2015, was performed. We analyzed the type of procedure, associated complications, and critical legal points from the recorded judgments along with any liability limitations on surgeons...
December 2016: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/27904295/retraction-ampelopsis-japonica-makino-extract-inhibits-the-inflammatory-reaction-induced-by-pathogen-associated-molecular-patterns-in-epidermal-keratinocytes
#4
Mi-Ra Choi, Dae-Kyoung Choi, Ki-Duck Kim, Sue Jeong Kim, Dong-Il Kim, Myung Im, Young Lee, Young-Joon Seo, Chang Deok Kim, Jeung-Hoon Lee
[This retracts the article on p. 352 in vol. 28, PMID: 27274634.].
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27903466/preoperative-3-dimensional-magnetic-resonance-imaging-of-uterine-myoma-and-endometrium-prior-to-myomectomy
#5
Young Jae Kim, Kwang Gi Kim, Seung Hyun Lee, Byung Chul Kang, Sa Ra Lee
Uterine myomas are the most common gynecologic benign tumor affecting women of childbearing age, and myomectomy is the main surgical option to preserve the uterus and fertility. During myomectomy for women with multiple myomas, it is advisable to identify and remove as many as possible to decrease the risk of future myomectomies. With deficient preoperative imaging, gynecologists are challenged to identify the location and size of myomas and the endometrium, which in turn can lead to uterine rupture during future pregnancies...
November 26, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27901471/esculetin-exerts-anti-proliferative-effects-against-non-small-cell-lung-carcinoma-by-suppressing-specificity-protein-1-in-vitro
#6
Ra H Lee, Young-Joo Jeon, Jin H Cho, Jeong-Yun Jang, Il-Keun Kong, Seok-Ho Kim, MinSeok S Kim, Hak-Jae Chung, Keon B Oh, Seon-Min Park, Jae-Cheon Shin, Jae-Min Seo, Sungho Ko, Jung-Hyun Shim, Jung-Il Chae
Esculetin, a coumarin derivative, is a phenolic compound isolated from Artemisia capillaris, Citrus limonia, and Euphorbia lathyris. Although it has been reported to have anti-inflammatory, anti-oxidant, and anti-proliferative activities in several human cancers, its anti-proliferative activity against non-small-cell lung carcinoma (NSCLC) and the molecular mechanisms involved have not been adequately elucidated. In this study, we used two NSCLC cell lines (NCI-H358 and NCI-H1299) to investigate the anti-proliferative activity and apoptotic effect of esculetin...
November 30, 2016: General Physiology and Biophysics
https://www.readbyqxmd.com/read/27897208/beta-1-integrin-ligation-and-tlr-ligation-enhance-gm-csf-induced-aldh1a2-expression-in-dendritic-cells-but-differentially-regulate-their-anti-inflammatory-properties
#7
Aya Yokota-Nakatsuma, Yoshiharu Ohoka, Hajime Takeuchi, Si-Young Song, Makoto Iwata
Retinoic acid (RA)-producing CD103(+) mature dendritic cells (DCs) in mesenteric lymph nodes (MLNs) play crucial roles in gut immunity. GM-CSF and RA contribute to the expression of the RA-producing enzyme ALDH1A2. However, additional signals appeared to be required for inducing ALDH1A2(high) mature DCs from immature DCs. We found here that TLR ligands (Ls) and immobilized E-cadherin could provide such signals in FLT3-L-generated bone marrow (BM)-derived DCs after treatment with GM-CSF and the RA receptor agonist Am80...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896910/novel-delivery-technique-for-atrial-septal-defect-closure-in-young-children-utilizing-the-gore-%C3%A2-cardioform-%C3%A2-septal-occluder
#8
Jason H Anderson, Hannah Fraint, Phillip Moore, Allison K Cabalka, Nathaniel W Taggart
OBJECTIVES: To develop a novel delivery technique to overcome vascular size limitations for device closure of a secundum ASD in the young patient. BACKGROUND: The efficacy, clinical utility, and safety of transcatheter closure in comparison to surgical closure are well established; however, access vessel size remains a potential limitation to device selection in the young patient. METHODS: A retrospective medical record review of all cases of secundum ASD closure between April 2015 and April 2016 utilizing a novel delivery method described herein at two separate academic institutions...
November 29, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27895468/increased-localized-delivery-of-piroxicam-by-cationic-nanoparticles-after-intra-articular-injection
#9
Sung Rae Kim, Myoung Jin Ho, Sang Hyun Kim, Ha Ra Cho, Han Sol Kim, Yong Seok Choi, Young Wook Choi, Myung Joo Kang
Piroxicam (PRX), a potent nonsteroidal anti-inflammatory drug, is prescribed to relieve postoperative and/or chronic joint pain. However, its oral administration often results in serious gastrointestinal adverse effects including duodenal ulceration. Thus, a novel cationic nanoparticle (NP) was explored to minimize the systemic exposure and increase the retention time of PRX in the joint after intra-articular (IA) injection, by forming micrometer-sized electrostatic clusters with endogenous hyaluronic acid (HA) in the synovial cavity...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27883370/epstein-barr-virus-associated-hemophagocytic-syndrome-after-scrub-typhus-infection
#10
Jeong Woo Hong, Hyun Seon You, Tae Won Lee, Won Yong Jo, Bo Ra Kim, Young Sun Suh, In Gyu Bae, Oh Hyun Cho
There have been a small number of cases of scrub typhus-associated hemophagocytic syndrome (HPS), most of which were treated successfully using adequate antibiotics. Here, we report a case of Epstein-Barr virus (EBV)-associated HPS after scrub typhus infection that was not improved using antirickettsial treatment. A 73-year-old male who had been diagnosed with scrub typhus according to an eschar and a positive serology was transferred to our institution because of a persistent fever despite 7-day doxycycline therapy...
November 8, 2016: Infection & Chemotherapy
https://www.readbyqxmd.com/read/27866354/isolation-and-characterization-of-a-novel-glycosyl-hydrolase-family-74-gh74-cellulase-from-the-black-goat-rumen-metagenomic-library
#11
Yun-Hee Song, Kyung-Tai Lee, Jin-Young Baek, Min-Ju Kim, Mi-Ra Kwon, Young-Joo Kim, Mi-Rim Park, Haesu Ko, Jin-Sung Lee, Keun-Sung Kim
This study aimed to isolate and characterize a novel cellulolytic enzyme from black goat rumen by using a culture-independent approach. A metagenomic fosmid library was constructed from black goat rumen contents and screened for a novel cellulase. The KG37 gene encoding a protein of 858 amino acid residues (92.7 kDa) was isolated. The deduced protein contained a glycosyl hydrolase family 74 (GH74) domain and showed 77% sequence identity to two endo-1,4-β-glucanases from Fibrobacter succinogenes. The novel GH74 cellulase gene was overexpressed in Escherichia coli, and its protein product was functionally characterized...
November 19, 2016: Folia Microbiologica
https://www.readbyqxmd.com/read/27864717/intraoperative-localization-of-the-parathyroid-glands-with-indocyanine-green-and-firefly-r-technology-during-baba-robotic-thyroidectomy
#12
Hyeong Won Yu, Joon Woo Chung, Jin Wook Yi, Ra-Yeong Song, Joon-Hyop Lee, Hyungju Kwon, Su-Jin Kim, Young Jun Chai, June Young Choi, Kyu Eun Lee
BACKGROUND: It is unclear whether near-infrared (NIR) light-induced indocyanine green (ICG) fluorescence can effectively identify, and thus permit the preservation of, parathyroid glands in bilateral axillo-breast approach (BABA) robotic thyroidectomy. This case-control study with a prospectively recruited consecutive series and a retrospectively selected control group assessed the usefulness of ICG with Firefly(R) technology to identify the parathyroid glands intraoperatively during BABA robotic thyroidectomy...
November 18, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27847747/healing-outcomes-of-root-canal-treatment-for-c-shaped-mandibular-second-molars-a-retrospective-analysis
#13
Hye-Ra Ahn, Young-Mi Moon, Sung-Ok Hong, Min-Seock Seo
OBJECTIVES: This study aimed to evaluate the healing rate of non-surgical endodontic treatment between C-shaped and non-C-shaped mandibular second molars. MATERIALS AND METHODS: Clinical records and radiological images of patients who had undergone endodontic treatment on mandibular second molars between 2007 and 2014 were screened. The periapical index scoring system was applied to compare healing outcomes. Information about preoperative and postoperative factors as well as the demographic data of the patients was acquired and evaluated using chi-square and multinomial logistic regression tests...
November 2016: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/27847572/risk-factors-for-the-development-and-progression-of-atlantoaxial-subluxation-in-surgically-treated-rheumatoid-arthritis-patients-considering-the-time-interval-between-rheumatoid-arthritis-diagnosis-and-surgery
#14
Min-Kyun Na, Hyoung-Joon Chun, Koang-Hum Bak, Hyeong-Joong Yi, Je Il Ryu, Myung-Hoon Han
OBJECTIVE: Rheumatoid arthritis (RA) is a systemic disease that can affect the cervical spine, especially the atlantoaxial region. The present study evaluated the risk factors for atlantoaxial subluxation (AAS) development and progression in patients who have undergone surgical treatment. METHODS: We retrospectively analyzed the data of 62 patients with RA and surgically treated AAS between 2002 and 2015. Additionally, we identified 62 patients as controls using propensity score matching of sex and age among 12667 RA patients from a rheumatology registry between 2007 and 2015...
November 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27845373/novel-synthetic-e-2-methoxy-4-3-4-methoxyphenyl-prop-1-en-1-yl-phenol-inhibits-arthritis-by-targeting-signal-transducer-and-activator-of-transcription-3
#15
Dong Ju Son, Dae Hwan Kim, Seong-Su Nah, Mi Hee Park, Hee Pom Lee, Sang Bae Han, Udumula Venkatareddy, Benjamin Gann, Kevin Rodriguez, Scott R Burt, Young Wan Ham, Yu Yeon Jung, Jin Tae Hong
Rheumatoid arthritis (RA) is a severely debilitating chronic autoimmune disease that leads to long-term joint damage. Signal transducer and activator of transcription 3 (STAT3)-targeted small molecules have shown promise as therapeutic drugs for treating RA. We previously identified (E)-2,4-bis(p-hydroxyphenyl)-2-butenal (BHPB), a tyrosine-fructose Maillard reaction product, as a small molecule with potent anti-inflammatory and anti-arthritic properties, mediated through the inhibition of STAT3 activation. The aim of this study was to develop a novel BHPH derivative with improved anti-arthritic properties and drug-likeness...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27844155/correlation-between-circulating-vegf-levels-and-disease-activity-in-rheumatoid-arthritis-a%C3%A2-meta-analysis
#16
Young Ho Lee, Sang-Cheol Bae
OBJECTIVE: To systematically review evidence regarding the relationship between circulating vascular endothelial growth factor (VEGF) levels and rheumatoid arthritis (RA), the correlation between serum VEGF levels and RA activity, and the association between VEGF polymorphisms and RA susceptibility. METHODS: We conducted a meta-analysis of the serum/plasma VEGF levels in patients with RA and controls, the correlation coefficients between the circulating VEGF levels and disease activity in patients with RA, and the association between VEGF -2578 A/C, -634 C/G, +936 T/C, and -1154 A/G polymorphisms and the risk for RA...
November 14, 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27823968/therapeutic-effect-of-erythroid-differentiation-regulator-1-erdr1-on-collagen-induced-arthritis-in-dba-1j-mouse
#17
Kyung Eun Kim, Sungryung Kim, Sunyoung Park, Younkyung Houh, Yoolhee Yang, Seung Beom Park, Sangyoon Kim, Daejin Kim, Dae Young Hur, Seonghan Kim, Hyun Jeong Park, Sa Ik Bang, Daeho Cho
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, and multiple inflammatory cytokines are involved in RA pathogenesis. Interleukin (IL)-18, in particular, has a significant positive correlation with RA. In this study, we investigated the effect of erythroid differentiation regulator 1 (Erdr1), which is negatively regulated by IL-18, in an animal model of inflammatory arthritis, collagen-induced arthritis (CIA) in DBA/1J mice. Treatment of mice with recombinant (r)Erdr1 significantly suppressed the severity of arthritis, histologic features of arthritic tissue, and serum levels of anti-collagen autoantibodies (IgG, IgG1, IgG2a and IgM) in CIA...
November 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27822936/analysis-of-malpractice-claims-associated-with-surgical-site-infection-in-the-field-of-plastic-surgery
#18
Bo Young Park, Jung Woo Kwon, So Ra Kang, Seung Eun Hong
Postoperative infections are rare after plastic surgery; however, when present, they can affect the aesthetic outcome. Currently, many malpractice lawsuits are associated with surgical site infection. The present study aimed to analyze malpractice claims associated with surgical site infection in the field of plastic surgery through a review of Korean precedents. We analyzed the type of procedure, associated complications, and legal judgment in these cases. Most claimants were women, and claims were most often related to breast surgery...
December 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27822928/factors-contributing-to-discordance-between-the-2011-acr-eular-criteria-and-physician-clinical-judgment-for-the-identification-of-remission-in-patients-with-rheumatoid-arthritis
#19
Yoon Kyoung Sung, Soo Kyung Cho, Dam Kim, Bo Young Yoon, Chan Bum Choi, Hoon Suk Cha, Jung Yoon Choe, Won Tae Chung, Seung Jae Hong, Jae Bum Jun, Young Mo Kang, Jinseok Kim, Tae Hwan Kim, Tae Jong Kim, Eunmi Koh, Choong Ki Lee, Jisoo Lee, Shin Seok Lee, Sung Won Lee, Hye Soon Lee, Yeon Ah Lee, Sung Hoon Park, Dae Hyun Yoo, Wan Hee Yoo, Sang Cheol Bae
Remission is a primary end point of in clinical practice and trials of treatments for rheumatoid arthritis (RA). The 2011 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria were developed to provide a consensus definition of remission. This study aimed to assess the concordance between the new remission criteria and the physician's clinical judgment of remission and also to identify factors that affect the discordance between these two approaches. A total of 3,209 patients with RA were included from the KORean Observational Study Network for Arthritis (KORONA) database...
December 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27811914/update-on-the-genetic-architecture-of-rheumatoid-arthritis
#20
REVIEW
Kwangwoo Kim, So-Young Bang, Hye-Soon Lee, Sang-Cheol Bae
Human genetic studies into rheumatoid arthritis (RA) have uncovered more than 100 genetic loci associated with susceptibility to RA and have refined the RA-association model for HLA variants. The majority of RA-risk variants are highly shared across multiple ancestral populations and are located in noncoding elements that might have allele-specific regulatory effects in relevant tissues. Emerging multi-omics data, high-density genotype data and bioinformatic approaches are enabling researchers to use RA-risk variants to identify functionally relevant cell types and biological pathways that are involved in impaired immune processes and disease phenotypes...
November 4, 2016: Nature Reviews. Rheumatology
keyword
keyword
94595
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"