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Young RA

Jin-Sung Park, Kyu-Dong Shim, Young-Sik Song, Ye-Soo Park
BACKGROUND CONTEXT: The influence of rheumatoid arthritis (RA) on the lumbar spine has received relatively little attention compared with cervical spine, and few studies have been conducted for adjacent segment disease (ASD) after lumbar fusion in the patients with RA. PURPOSE: To determine the incidence of ASD requiring surgery (ASDrS) after short lumbar fusion and to evaluate risk factors of ASDrS, including RA. STUDY DESIGN: Retrospective cohort study PATIENT SAMPLE: This study included 479 patients who underwent lumbar spinal fusion of 3 or fewer levels, with the mean follow-up period of 51...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
Kiri Patton, Jason P Connor, Sharyn Rundle-Thiele, Timo Dietrich, Ross McD Young, Matthew J Gullo
BACKGROUND: This study aimed to develop and validate a shortened version of the Drinking Refusal Self-Efficacy Questionnaire-Revised Adolescent version (DRSEQ-RA) using a large sample of adolescents. METHODS: Secondary school students (N = 2609, M = 14.52 years, SD = 0.94) completed the DRSEQ-RA (consisting of subscales: Social Pressure; Opportunistic; Emotional Relief) and the Alcohol Use Disorders Identification Test (AUDIT). These data were analysed using non-parametric item response theory (NIRT) including Mokken scalability coefficients, and confirmatory factor analysis...
February 5, 2018: Addictive Behaviors
Wanlu Li, Mi-Ra Lee, Taeyeong Kim, Young Wan Kim, Mee-Yon Cho
The activation of signal transducer and activator of transcription 3 (STAT3) by elevated interleukin (IL) levels has been reported to regulate tumorigenesis both in vitro and in vivo. However, the clinical implication of p-STAT3 expression in colon cancer is still controversial. In this study, we evaluated the effect of STAT3 inactivation on biologic behavior of primary (Caco-2) and metastatic colon cancer cells (LoVo and SNU407) and the relation of p-STAT3 expression with the invasion of colon tumor. In vitro study, the STAT3 inhibition by siRNA and stattic treatment significantly reduced colony formation and cell migration and decreased CD133 and survivin the expression compared with a control in all three cell lines...
February 9, 2018: Biochemical and Biophysical Research Communications
Jung Woo Kwon, Seung Eun Hong, So Ra Kang, Bo Young Park
BACKGROUND: Human placental extract (HPE), prepared from the placentas of healthy, postpartum females, displays various physiological activities, including antioxidative properties. In this study, a dorsal skin flap model was used to investigate the effect of HPE on flap viability in rats. MATERIALS AND METHODS: Forty male Sprague-Dawley rats underwent random-pattern skin flap surgeries. The animals were randomly divided among a control group and three treatment groups (localized injection (LI), 10 mg/kg/d localized HPE injections; low-dose treatment (LT), 10 mg/kg/d systemic HPE injections; high-dose treatment (HT), 40 mg/kg/d systemic HPE injections)...
February 12, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Y Luo, W C Blackledge
Worldwide, the growing obesity pandemic contributes to a range of chronic diseases. Recent epidemiological studies have suggested an association between obesity and the development of rheumatoid arthritis (RA), particularly among young women, whereby pro-inflammatory effects of adipokines provide one explanatory hypothesis. Yet, recent clinical and laboratory-based studies provide emerging evidence indicating microbiome involvement in RA initiation and development, including anti-citrullinated antibody formation and Th17 cell activation...
February 9, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Joseph Jacob, Jin Woo Song, Hee-Young Yoon, Gary Cross, Joseph Barnett, Wen Ling Woo, Fern Adams, Maria Kokosi, Anand Devaraj, Elisabetta Renzoni, Toby M Maher, Dong Soon Kim, Athol U Wells
AIMS: Autoimmune conditions such as rheumatoid arthritis-related interstitial lung disease (RA-ILD) have been linked to the existence of emphysema in never-smokers. We aimed to quantify emphysema prevalence in RA-ILD never-smokers and investigate whether combined pulmonary fibrosis and emphysema (CPFE) results in a worsened prognosis independent of baseline disease extent. METHODS: RA-ILD patients presenting to the Royal Brompton Hospital (n=90) and Asan Medical Center (n=155) had CT's evaluated for a definite usual interstitial pneumonia (UIP) pattern, and visual extents of emphysema and ILD...
January 31, 2018: EBioMedicine
Hee Jae Huh, Dong Joon Song, Hyang Jin Shim, Won Kyung Kwon, Min-Seung Park, Mi Ra Ryu, Eun Hye Cho, Jongwon Oh, In Young Yoo, Nam Yong Lee
Objectives: To evaluate the performance of a rapid antimicrobial susceptibility testing (AST) platform based on microfluidic chip technology, the QMAC-dRAST, which enables AST from colony isolates or positive blood culture broth (PBCB), and to compare the performance of the QMAC-dRAST for staphylococci and enterococci with that of the VITEK-2 system based on reference broth microdilution (BMD). Methods: A total of 110 staphylococcal and enterococcal isolates from blood cultures were included...
February 3, 2018: Journal of Antimicrobial Chemotherapy
Sang-Cheol Bae, Young Ho Lee
The relative efficacy and tolerability of tocilizumab, sarilumab, and sirukumab were assessed in patients with rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX) or tumor necrosis factor (TNF) inhibitors. We performed a Bayesian network meta-analysis to combine direct and indirect evidence from randomized controlled trials (RCTs) to examine the efficacy and safety of tocilizumab, sarilumab, and sirukumab in RA patients and an inadequate MTX or TNF inhibitor response. Fourteen RCTs, comprising 9753 patients, met the inclusion criteria...
February 5, 2018: Clinical Rheumatology
Ra Gyoung Yoon, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee
PURPOSE: This study evaluated the characteristics of a thyroid-dedicated bipolar RF electrode (BRFE) and compared its ablation performance with that of monopolar RF electrodes (MRFEs) in normal bovine liver blocks Methods: BRFE was tested on 60 bovine liver blocks with six different time-power combinations, applying 20, 30, and 40 watts (W) for 60 and 120 seconds (sec). Subsequently, BRFE and MRFEs with 0.5-, 0.7- and 1-cm active tips were applied on 160 bovine liver blocks, creating 16 time-electrode combinations (10, 30, 60, 120 sec)...
February 6, 2018: International Journal of Hyperthermia
Young Chul Sim, Seung-Hyuk Lim, Yang-Seok Yoo, Min-Ho Jang, Sunghan Choi, Hwan-Seop Yeo, Kie Young Woo, Sangwon Lee, Hyun Gyu Song, Yong-Hoon Cho
Warm and natural white light (i.e., with a correlated colour temperature <5000 K) with good colour rendition (i.e., a colour rendering index >75) is in demand as an indoor lighting source of comfortable interior lighting and mood lighting. However, for warm white light, phosphor-converted white light-emitting diodes (WLEDs) require a red phosphor instead of a commercial yellow phosphor (YAG:Ce3+), and suffer from limitations such as unavoidable energy conversion losses, degraded phosphors and high manufacturing costs...
February 2, 2018: Nanoscale
Sang-Cheol Bae, Young Ho Lee
We aimed to assess the relative efficacy and safety of biosimilar adalimumab and originator adalimumab plus methotrexate (MTX) compared to those of placebo plus MTX in patients with active rheumatoid arthritis (RA) who showed an inadequate response to MTX. We performed a Bayesian network meta-analysis to combine direct and indirect evidence from randomized controlled trials (RCTs) examining the efficacy and safety of biosimilar + MTX and adalimumab + MTX versus placebo + MTX (MTX group) in patients with active RA despite treatment with MTX...
February 1, 2018: Clinical Rheumatology
Gareth Lingham, Elizabeth Milne, Donna Cross, Dallas R English, Robyn S Johnston, Robyn M Lucas, Seyhan Yazar, David A Mackey
INTRODUCTION: Excessive and insufficient sun exposure during childhood have been linked to serious diseases in later life; for example, insufficient sun exposure during childhood may increase the risk of developing myopia. The Kidskin-Young Adult Myopia Study (K-YAMS) is a follow-up of participants in the Kidskin Study, a non-randomised controlled trial that evaluated the effect of a 4-year educational intervention on sun-protection behaviours among primary school children in the late 1990s...
January 31, 2018: BMJ Open
Sang-Cheol Bae, Young Ho Lee
OBJECTIVE: The aim of this study was to investigate whether the thymidylate synthase (TYMS) 2R/3R and 6 bp I/D polymorphisms can predict the response to or toxicity of methotrexate (MTX) in patients with rheumatoid arthritis (RA). METHODS: We conducted a meta-analysis of studies on the association between the TYMS 2R/3R and 6 bp I/D polymorphisms and non-responsiveness to or toxicity of MTX in RA patients. RESULTS: A total of 11 studies involving 1613 patients were considered...
January 29, 2018: Zeitschrift Für Rheumatologie
Ji Hyun Chung, Hae Rim Jung, Ah Ra Jung, Young Chan Lee, Moonkyoo Kong, Ju-Seog Lee, Young-Gyu Eun
SOX2 copy number and mRNA expression were analysed to examine the clinical significance of SOX2 activation in HNSCC. Gene expression signatures reflecting SOX2 activation were identified in an HNSCC cohort. Patients with HNSCC were classified into two subgroups according to the gene expression signature: SOX2-high and SOX2-low. The clinical significance of SOX2 activation was further validated in two independent cohorts. Moreover, clinical significance of SOX2 activation in response to radiotherapy was assessed in patients with HNSCC...
January 26, 2018: Scientific Reports
Eun-Kyung Kim, Seung Hoon Lee, Seon-Young Lee, Jae-Kyung Kim, Joo Yeon Jhun, Hyun Sik Na, Se-Young Kim, Jong Young Choi, Chul Woo Yang, Sung-Hwan Park, Mi-La Cho
Rheumatoid arthritis (RA) is a systemic autoimmune disease involving excessive inflammation. Recently, RA associated with a metabolic disorder was revealed to be non-responsive to RA medications. Metformin has been reported to have a therapeutic effect on RA and obesity. The aim of this investigation was to study the therapeutic effect and the underlying mechanism of metformin's action in an experimental model of collagen-induced arthritis (CIA) associated with obesity. Metformin was administered daily for 13 weeks to mice with CIA that had been fed a high-fat diet...
January 26, 2018: Experimental & Molecular Medicine
Soo-Jin Kim, Yong-Seok Song, Thu-Huyen Pham, Yesol Bak, Hee-Pom Lee, Jin-Tae Hong, Do-Young Yoon
(E)-2-Methoxy-4- (3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP), a new (E)-2,4-bis(p-hydroxyphenyl)-2 - butenal derivative, reportedly has therapeutic effects such as anti-arthritic properties. Although previous studies showed that MMPP has anti-arthritic effects on rheumatoid arthritis (RA), the anti-inflammation mechanism of MMPP remains unclear. In this study, phorbol-12-myristate 13-acetate (PMA) was used as an inflammatory stimulus to evaluate the detailed mechanism of the MMPP-mediated anti-inflammatory effect in human monocytic THP-1 cells...
January 22, 2018: European Journal of Pharmacology
Matthew S Stone, Jordan M Glenn, Jennifer L Vincenzo, Michelle Gray
Stone, MS, Glenn, JM, Vincenzo, JL, and Gray, M. Comparison of exercise performance in recreationally active and masters athlete women. J Strength Cond Res 32(2): 565-571, 2018-Master athletes (MA) are an understudied, ever-growing cohort. As such, it is important to examine how age affects muscular power and fatigability. Of particular interest is muscular power maintenance and fatigue mitigation of MA compared with young, healthy adults. The purpose of this investigation was to examine the differences in peak power, average power, total work (WRK), and fatigue index (FI) between recreationally active (RA) younger adults and female MA during anaerobic cycling exercise...
February 2018: Journal of Strength and Conditioning Research
Young Chan Lee, Jun Seok Lee, Ah Ra Jung, Jung Min Park, Young-Gyu Eun
Objectives: To examine the factors which affect the improvement or the recurrence of disease after intralesional steroid injection in patients with oral lichen planus (OLP). Methods: Sixty-two patients diagnosed as OLP were treated with intralesion corticosteroid injection. To evaluate the objective severity of OLP, total severity score of OLP was assessed. To examine the factors affecting the therapeutic effect of intralesional steroid injection, factors were compared between the symptom-improved group and symptom-not-improved group...
January 26, 2018: Clinical and Experimental Otorhinolaryngology
Go Hun Seo, Jin-Ho Choi, Yoon-Myung Kim, Kyung-Nam Koh, Ho Joon Im, Young Shin Ra, Han-Wook Yoo
As survival rates have improved owing to advances in management strategies for pediatric brain tumors, long-term complications such as endocrine dysfunction, have emerged as a major issue. This study investigated the long-term endocrine effects of childhood-onset brain tumors in a large number of patients. This study included 151 patients with brain tumors diagnosed between January 1995 and December 2016. The following data were retrospectively reviewed: tumor location, tumor histology, endocrine abnormalities, hypothalamic involvement on brain imaging, treatment modalities, and trends in body mass index...
January 19, 2018: Journal of Neuro-oncology
Seon-Young Lee, Seung Hoon Lee, JooYeon Jhun, Hyeon-Beom Seo, Kyung Ah Jung, Chul Woo Yang, Sung-Hwan Park, Mi-La Cho
Probiotic complex, zinc, and coenzyme Q10 (CoQ10) are recognized dietary supplements with an anti-inflammatory role. Although these supplementations are individually known to benefit rheumatoid arthritis (RA), there is no evidence suggesting any synergic effect. The primary goal of this study is to determine whether probiotic complex, zinc, and CoQ10 attenuate the development of collagen-induced arthritis (CIA). The combination of probiotic complex, zinc, and CoQ10 reduced CIA severity by downregulating the levels of IgG, IgG1, and IgG2a in serum...
January 2018: Journal of Medicinal Food
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