keyword
https://read.qxmd.com/read/38534181/outdoor-artificial-light-at-night-and-reproductive-endocrine-and-glucose-homeostasis-and-polycystic-ovary-syndrome-in-women-of-reproductive-age
#21
JOURNAL ARTICLE
Lanlan Fang, Cong Ma, Guosheng Wang, Yongzhen Peng, Hui Zhao, Yuting Chen, Yubo Ma, Guoqi Cai, Yunxia Cao, Faming Pan
BACKGROUND: Artificial light at night, a well-recognized circadian clock disrupter, causes disturbances in endocrine homeostasis. However, the association of artificial light at night with polycystic ovary syndrome (PCOS) is still unknown. This study examines the effects of outdoor artificial light at night on sex hormones, glucose homeostasis markers, and PCOS prevalence in Anhui Province, China. METHODS: We recruited 20633 women of reproductive age from Anhui Medical University Reproductive Medicine Center...
March 22, 2024: Epidemiology
https://read.qxmd.com/read/38533745/-the-design-and-acceptability-of-a-hip-hop-themed-integrated-nutrition-math-curriculum-for-minoritized-5th-grade-students-using-the-multisensory-multilevel-health-education-model
#22
JOURNAL ARTICLE
Ewelina M Swierad, John C Rausch, Vanessa Sawyer, Gabriela Drucker, Olajide Williams
Digital technology creates new opportunities to design multisensory learning experiences. Evidence suggests that digital innovation can greatly benefit health education, including nutrition programs. The COVID-19 pandemic disrupted the education sector, forcing schools to modify standard practices from exclusively in-person delivery to online or blended learning. Digitalized curriculums became particularly useful as an Emergency Remote Teaching tool. This article focuses on developing and implementing a multimedia, multisensory, and scalable Hip-Hop Healthy Eating and Living in Schools (H...
March 27, 2024: Health Promotion Practice
https://read.qxmd.com/read/38533606/a-randomised-controlled-trial-of-medication-adherence-and-management-of-risk-factors-for-secondary-prevention-of-stroke-mamors-using-a-smartphone-based-application
#23
JOURNAL ARTICLE
Veena Babu, P N Sylaja, Biju Soman, Ravi Prasad Varma, Manju M S, G L Geethu, Suresh Kumar
BACKGROUND: There is little data on the use of smartphone-based applications for medication adherence and risk-factor control for the secondary prevention of stroke in low-and-middle-income countries (LMIC). AIMS: To determine whether a smartphone-based app improved medication adherence, risk-factor control, and provided health education to stroke survivors for lifestyle and behavioural modifications. METHODS: An unblinded, single-centre randomized controlled double arm trial with 1:1 allocation among stroke survivors was performed in South India...
March 27, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38533552/taar1-agonist-ulotaront-delays-gastric-emptying-of-solids-in-patients-with-schizophrenia-and-concurrent-metabolic-syndrome-with-prediabetes
#24
JOURNAL ARTICLE
Snežana Milanović, Nina Dedic, Robert Lew, Duane Burton, Kenneth S Koblan, Michael Camilleri, Seth C Hopkins
BACKGROUND: Metabolic syndrome (MetS), which can be induced or exacerbated by the current class of antipsychotic drugs, is highly prevalent in patients with schizophrenia and presents significant challenges to lifetime disease management. Supported by initial clinical results, trace amine-associated receptor 1 (TAAR1) agonists have emerged as potential novel treatments for schizophrenia. Notably, non-clinical studies have also shown weight-lowering and glucoregulatory effects of TAAR1 agonists, including the investigational agent ulotaront...
March 27, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38533464/sex-differences-in-waist-circumference-obesity-and-eating-speed-a-cross-sectional-study-of-japanese-people-with-normal-body-mass-index
#25
JOURNAL ARTICLE
Yuri Yaguchi, Tsuneo Konta, Nahomi Imaeda, Chiho Goto, Yoshiyuki Ueno, Takamasa Kayama
BACKGROUND: Fast eating has been positively associated with visceral fat accumulation in normal-weight individuals according to body mass index (BMI). However, previous studies have not examined energy and nutrients, or adjusted for food intake. We examined the relationship between eating speed and visceral fat accumulation, using waist circumference as an index, in middle-aged participants who were considered to be of standard weight according to BMI, with nutrient intake added as an adjustment factor...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38533289/screening-of-individuals-with-type-2-diabetes-on-anti-diabetic-agents-for-probable-hypoglycaemia-using-the-stanford-hypoglycemia-questionnaire-shq-in-outpatient-settings-a-cross-sectional-study-from-outpatient-diabetes-care-centres-in-north-india
#26
JOURNAL ARTICLE
Rajiv Awasthi, Arun K Pande, Kumar P Chandra, Vivek Agarwal, Mukulesh Gupta, Ajoy Tewari, Nitin Gupta, Santosh Chaubey, Sandeep Chaudhary, Sajid Ansari, Dinesh Kumar
INTRODUCTION: The study was aimed at identifying the incidence of unreported probable hypoglycaemia in individuals with type 2 diabetes (T2DM) on anti-diabetic medications, using the screening Stanford Hypoglycemia Questionnaire (SHQ) in real-world situations. METHODS: It was a multicentre cross-sectional study on consecutive individuals attending 10 diabetes care centres in Lucknow, Uttar Pradesh, India. The inclusion criteria were as follows: known individuals with T2DM, literate, age greater than or equal to 18 years, on at least one anti-diabetic agent for more than a month and not engaged in regular self-monitoring of blood glucose (SMBG)...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533267/triglyceride-glucose-index-as-an-indicator-of-cardiovascular-risk-in-syrian-refugees
#27
JOURNAL ARTICLE
Ameerah Hasan Ibrahim, Alaa Mahmoud Hammad, Walid Al-Qerem, Hakam Alaqabani, F Scott Hall, Fawaz Alasmari
BACKGROUND: The triglyceride glucose (TyG) index is a quick and inexpensive approach to measure insulin resistance. The aim of this study was to evaluate the TyG index's ability to predict cardiovascular risk and determine the TyG index cutoff values in Syrian refugees. METHODS: A retrospective research study was conducted with 756 Syrian refugees. Data on demographics and clinical laboratory assessments were obtained from refugee's files. The formula Ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg (dL)/2] was used to calculate the TyG index...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38532980/role-of-remnant-cholesterol-in-the-relationship-between-physical-activity-and-diabetes-mellitus-an-intermediary-analysis
#28
JOURNAL ARTICLE
Zihua Yang, Hao Chen, Fengxia Lai, Jingjing Zhang, Shihong Wang, Shuang Wang, Yongze Chen, Zhenhua Mai, Ling Luo, Danli Kong, Yuanlin Ding
OBJECTIVE: The purpose of this investigation was to evaluate the potential link between physical activity (PA) and the heightened susceptibility to diabetes mellitus (DM), by examining whether remnant cholesterol (RC) might act as a mediator in this correlation. METHODS: The research utilized data from the National Health and Nutrition Examination Survey, spanning from 2005 to 2018. Various statistical analyses were conducted for continuous and categorical variables, including the t -test, ANOVA, and χ2 test...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38532858/anthranilic-acid-a-gpr109a-agonist-and-schizophrenia
#29
JOURNAL ARTICLE
Gregory Oxenkrug, Brent Forester
INTRODUCTION: Limited clinical efficiency of current medications warrants search for new antipsychotic agents. Deorphanized G-protein coupled receptor (GPR)109A has not attracted much of attention of schizophrenia researchers. We analyzed literature and our data on endogenous agonists of GPR109A, beta-hydroxybutyrate (BHB), anthranilic (AA), butyric (BA), and nicotinic (NA) acids, in individuals with schizophrenia. DATA: Sex specific differences: plasma AA levels were 27% higher in female than in male patients and correlated with PANSS before 6 weeks of antipsychotics treatment ( r  = ...
2024: International Journal of Tryptophan Research: IJTR
https://read.qxmd.com/read/38532430/needle%C3%A2-based-gastrocnemius-lengthening-a-novel-ultrasound%C3%A2-guided-noninvasive-technique-part-ii-clinical-results
#30
JOURNAL ARTICLE
A Iborra, M Villanueva, H Fahandezh-Saddi Díaz
BACKGROUND: Isolated gastrocnemius contracture has been associated with more than 30 lower limb disorders, including plantar heel pain/plantar fasciitis, Achilles tendinosis, equinus foot, adult flatfoot, and metatarsalgia. Although many techniques are available for gastrocnemius recession, potential anesthetic, cosmetic, and wound-related complications can lead to patient dissatisfaction. Open and endoscopic recession techniques usually require epidural or general anesthesia, exsanguination of the lower extremities and stitches and can damage the sural nerve, which is not under the complete control of the surgeon at all stages of the procedure...
March 26, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38532414/combining-public-datasets-for-automated-tooth-assessment-in-panoramic-radiographs
#31
JOURNAL ARTICLE
Niels van Nistelrooij, Khalid El Ghoul, Tong Xi, Anindo Saha, Steven Kempers, Max Cenci, Bas Loomans, Tabea Flügge, Bram van Ginneken, Shankeeth Vinayahalingam
OBJECTIVE: Panoramic radiographs (PRs) provide a comprehensive view of the oral and maxillofacial region and are used routinely to assess dental and osseous pathologies. Artificial intelligence (AI) can be used to improve the diagnostic accuracy of PRs compared to bitewings and periapical radiographs. This study aimed to evaluate the advantages and challenges of using publicly available datasets in dental AI research, focusing on solving the novel task of predicting tooth segmentations, FDI numbers, and tooth diagnoses, simultaneously...
March 26, 2024: BMC Oral Health
https://read.qxmd.com/read/38531733/preparation-of-diblock-copolymer-nano-assemblies-by-ultrasonics-assisted-ethanol-phase-polymerization-induced-self-assembly
#32
JOURNAL ARTICLE
Xin Shao, Dan Li, Shengwei Guo, Jun Yan, Yongqiang Qian, Guxia Wang
Assemblies are widely used in biomedicine, batteries, functional coatings, Pickering emulsifiers, hydrogels, and luminescent materials. Polymerization-induced self-assembly (PISA) is a method for efficiently preparing particles, mainly initiated thermally. However, thermally initiated PISA usually requires a significant amount of time and energy. Here, we demonstrate the preparation of nano-assemblies with controllable morphologies and size using ultrasound (20 kHz) assisted ethanol-phase RAFT-PISA in three hours...
March 23, 2024: Ultrasonics Sonochemistry
https://read.qxmd.com/read/38531718/an-atmospheric-water-harvesting-system-based-on-the-optimal-harvesting-window-design-for-worldwide-water-production
#33
JOURNAL ARTICLE
Qian Li, Zhao Shao, Qihong Zou, Quanwen Pan, Yao Zhao, Yaohui Feng, Wenwen Wang, Ruzhu Wang, Tianshu Ge
Atmospheric water harvesting (AWH) is a promising solution to the water shortage problem. Current sorption-based AWH (SAWH) systems seldom obtain both wide climatic adaptability and high energy efficiency due to the lack of thermodynamic optimization. To achieve the ideal harvesting circulation in SAWH systems, the "optimal harvesting window" (OHW) design based on thermodynamic analysis was first proposed and validated by our prototype. The "OHW" theory indicates the water production rate and energy efficiency could be improved by properly reducing the adsorption temperature...
March 9, 2024: Science Bulletin
https://read.qxmd.com/read/38531632/deletion-of-the-clock-gene-bmal2-leads-to-alterations-in-hypothalamic-clocks-circadian-regulation-of-feeding-and-energy-balance
#34
JOURNAL ARTICLE
Rosana Dantas-Ferreira, Dominique Ciocca, Patrick Vuillez, Stéphanie Dumont, Christian Boitard, Ute C Rogner, Etienne Challet
BMAL2 (ARNTL2) is a paralog of BMAL1 that can form heterodimers with the other circadian factors CLOCK and NPAS2 to activate transcription of clock and clock-controlled genes. To assess a possible role of Bmal2 in the circadian regulation of metabolism, we investigated daily variations of energy metabolism, feeding behavior, and locomotor behavior, as well as ability to anticipate restricted food access in male mice knock-out for Bmal2 (B2KO). While their amount of food intake and locomotor activity were normal compared to wild-type mice, B2KO mice displayed increased adiposity (1...
March 26, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38531485/engineering-the-future-cereal-crops-with-big-biological-data-towards-an-intelligence-driven-breeding-by-design
#35
REVIEW
Lei Liu, Jimin Zhan, Jianbing Yan
How to feed 10 billion human populations is one of the challenges that need to be addressed in the following decades, especially under an unpredicted climate change. Crop breeding, initiating from the phenotype-based selection by local farmers and developing into current biotechnology-based breeding, has played a critical role in securing the global food supply. However, regarding the changing environment and ever-increasing human population, can we breed outstanding crop varieties fast enough to achieve high productivity, good quality, and widespread adaptability? This review outlines the recent achievements in understanding cereal crop breeding, including the current knowledge about crop agronomic traits, newly developed techniques, crop big biological data research, and the possibility of integrating them for intelligence-driven breeding by design, which ushers in a new era of crop breeding practice and shapes the novel architecture of future crops...
March 24, 2024: Journal of Genetics and Genomics
https://read.qxmd.com/read/38531464/do-we-understand-sex-related-differences-governing-dimorphic-disease-mechanisms-in-preclinical-animal-models-of-osteoarthritis
#36
JOURNAL ARTICLE
Mona Dvir-Ginzberg, Yonathan H Maatuf, Ali Mobasheri
Research conducted using murine preclinical models of osteoarthritis (OA) over the last three decades has brought forth many exciting developments showcasing mechanisms and pathways that ‎drive disease pathogenesis. These models have identified therapeutic targets that can be modulated via innovative biologicals and pharmaceuticals. However, many of these ‎approaches have failed to translate to humans and reach the clinic. This commentary aims to highlight some of the key ‎hurdles in the translation of novel findings using preclinical OA models...
March 24, 2024: Osteoarthritis and Cartilage
https://read.qxmd.com/read/38531251/machine-learning-based-predictive-model-for-abdominal-diseases-using-physical-examination-datasets
#37
JOURNAL ARTICLE
Wei Chen, YuJie Zhang, Weili Wu, Hui Yang, Wenxiu Huang
Abdominal ultrasound is a key non-invasive imaging method for diagnosing liver, kidney, and gallbladder diseases, despite its clinical significance, not all individuals can undergo abdominal ultrasonography during routine health check-ups due to limitations in equipment, cost, and time. This study aims to use basic physical examination data to predict the risk of diseases of the liver, kidney, and gallbladder that can be diagnosed via abdominal ultrasound. Basic physical examination data contain gender, age, height, weight, BMI, pulse, systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, triglycerides, fasting blood glucose (FBG), and uric acid-we established seven single-label predictive models and one multi-label predictive model...
March 11, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38531173/quality-assurance-for-focused-ultrasound-induced-blood-brain-barrier-opening-procedure-using-passive-acoustic-detection
#38
JOURNAL ARTICLE
Chih-Yen Chien, Lu Xu, Jinyun Yuan, Siaka Fadera, Andrew H Stark, Umeshkumar Athiraman, Eric C Leuthardt, Hong Chen
BACKGROUND: Focused ultrasound (FUS) combined with microbubbles is a promising technique for noninvasive, reversible, and spatially targeted blood-brain barrier opening, with clinical trials currently ongoing. Despite the fast development of this technology, there is a lack of established quality assurance (QA) strategies to ensure procedure consistency and safety. To address this challenge, this study presents the development and clinical evaluation of a passive acoustic detection-based QA protocol for FUS-induced blood-brain barrier opening (FUS-BBBO) procedure...
March 25, 2024: EBioMedicine
https://read.qxmd.com/read/38531155/two-lateral-flow-assays-for-detection-of-anti-coccidioidal-antibodies-show-similar-performance-to-immunodiffusion-in-dogs-with-coccidioidomycosis
#39
JOURNAL ARTICLE
Francisca J Grill, Jared A Jaffey, Thomas E Grys, Laura H Rayhel, Douglas F Lake
OBJECTIVE: To compare 2 point-of-care lateral flow assays (LFAs) with immunodiffusion (ID) IgG results for anti-coccidioidal antibody detection in dogs with coccidioidomycosis. A further aim was to compare the quantifiable output of 1 of the LFAs to ID antibody titers. SAMPLE: Serum banked from 73 client-owned dogs diagnosed with pulmonary or disseminated coccidioidomycosis. METHODS: ID was used to determine antibody presence and titer against a coccidioidal antigen preparation...
March 25, 2024: American Journal of Veterinary Research
https://read.qxmd.com/read/38531153/the-physiological-response-of-oriental-river-prawn-macrobrachium-nipponense-to-starvation-induced-stress
#40
JOURNAL ARTICLE
Fajun Li, Xiaocui Cui, Chunpeng Fu, Aili Wang
Environmental stresses play critical roles in the physiology of crustaceans. Food deprivation is an important environmental factor and a regular occurrence in both natural aquatic habitats and artificial ponds. However, the underlying physiological response mechanisms to starvation-caused stress in crustaceans are yet to be established. In the present study, the hepatopancreas tissue of Macrobrachium nipponense was transcriptome analyzed and examined for starvation effects on oxidative stress, DNA damage, autophagy, and apoptosis across four fasting stages (0 (control group), 7, 14, and 21 days)...
March 20, 2024: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
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