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https://www.readbyqxmd.com/read/29169222/metagenomic-approach-to-identifying-foodborne-pathogens-on-chinese-cabbage
#1
Daeho Kim, Sanghyun Hong, You-Tae Kim, Sangryeol Ryu, Hyeun Bum Kim, Ju-Hoon Lee
Foodborne illness represents a major threat to public health frequently attributed to pathogenic microorganisms on fresh produce. Recurrent outbreaks often come from vegetables that are grown close to or within the ground. Therefore, the first step to understanding the public health risk of microorganisms on fresh vegetables is to identify and describe microbial communities. We investigated phyllospheres on Chinese cabbage (Brassica rapa subsp. pekinensis, n=54). 16S rRNA gene amplicon sequencing targeting the V5-V6 region of 16S rRNA genes was conducted by employing the Illumina MiSeq system...
November 25, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29168965/relationships-between-metabolic-profile-hypertension-and-uric-acid-with-cardiometabolic-risk-in-adolescents-with-abdominal-obesity-impact-of-geodemographic-factors-on-the-prevalence-of-abdominal-obesity
#2
Hamida Bouhenni, Hadjer Daoudi, Haidar Djemai, Philippe Noirez, Abdelkader Rouabah, Damien Vitiello, Leila Rouabah
Background Association of hyperuricemia, dyslipidemia and high blood pressure (BP) among adolescents with high waist-to-height ratio (WHtR) remains not fully addressed and could represent a new way to diagnose adolescents early with cardiometabolic risk. Objective We aimed to determine abdominal obesity (AO) prevalence and investigate relations between AO, uric acid (UA), lipid profiles, BP and geographical patterns in adolescents. Subjects 577 and 204 Algerian students aged between 10 and 19 years were included in our epidemiological and biochemical studies, respectively...
November 23, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29168847/an-aptamer-and-functionalized-nanoparticle-based-strip-biosensor-for-on-site-detection-of-kanamycin-in-food-samples
#3
Jing Liu, Jingyi Zeng, Yaping Tian, Nandi Zhou
A lateral flow strip biosensor for fast, sensitive, low-cost and on-site detection of kanamycin was developed by using kanamycin-specific aptamer-modified gold nanoparticles (AuNPs-apt) as a probe and oligonucleotide DNA1-modified silver nanoparticles (AgNPs-DNA1) as a signal amplification element. Through the complementary sequences of DNA1 and the aptamer, the AgNP-DNA1-apt-AuNPs complex can be formed and further captured on the test zone of the strip, where a capture probe DNA2 complementary to the 3'-terminal of DNA1 was immobilized...
November 23, 2017: Analyst
https://www.readbyqxmd.com/read/29168766/tityus-serrulatus-scorpion-venom-in-vitro-tests-and-their-correlation-with-in-vivo-lethal-dose-assay
#4
Daniela Cajado-Carvalho, Juliana Galvão, Alexandre K Kuniyoshi, Patrícia Dos Santos Carneiro, Adriana Franco Paes Leme, Bianca Alves Pauletti, Eliana Blini Marengo, Fernanda V Portaro
Scorpion stings are the main cause of human envenomation in Brazil and, for the treatment of victims, the World Health Organization (WHO) recommends the use of antivenoms. The first step to achieve effective antivenom is to use a good quality venom pool and to evaluate it, with LD50 determination as the most accepted procedure. It is, however, time-consuming and requires advanced technical training. Further, there are significant ethical concerns regarding the number of animals required for testing. Hence, we investigated the correspondence between LD50 results, in vitro assays, and a strong correlation with proteolytic activity levels was observed, showing, remarkably, that proteases are potential toxicity markers for Tityus serrulatus venom...
November 23, 2017: Toxins
https://www.readbyqxmd.com/read/29168739/early-or-late-feeding-after-icu-admission
#5
REVIEW
Annika Reintam Blaser, Mette M Berger
The feeding of critically ill patients has recently become a controversial issue, as several studies have provided unexpected and contradictory results. Earlier beliefs regarding energy requirements in critical illness-especially during the initial phase-have been challenged. In the current review, we summarize existing evidence about fasting and the impact of early vs. late feeding on the sick organism's responses. The most important points are the non-nutritional advantages of using the intestine, and recognition that early endogenous energy production as an important player in the response must be integrated in the nutrient prescription...
November 23, 2017: Nutrients
https://www.readbyqxmd.com/read/29168715/emission-of-hydrogen-sulfide-h2s-at-a-waterfall-in-a-sewer-study-of-main-factors-affecting-h2s-emission-and-modeling-approaches
#6
Daniel Jung, Laetitia Hatrait, Julien Gouello, Arnaud Ponthieux, Vincent Parez, Christophe Renner
Hydrogen sulfide (H2S) represents one of the main odorant gases emitted from sewer networks. A mathematical model can be a fast and low-cost tool for estimating its emission. This study investigates two approaches to modeling H2S gas transfer at a waterfall in a discharge manhole. The first approach is based on an adaptation of oxygen models for H2S emission at a waterfall and the second consists of a new model. An experimental set-up and a statistical data analysis allowed the main factors affecting H2S emission to be studied...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29168550/aed-use-in-public-places-a-study-of-acquisition-time
#7
Wojciech Telec, Artur Baszko, Marek Dabrowski, Agata Dabrowska, Maciej Sip, Mateusz Puslecki, Tomasz Klosiewicz, Patrycja Potyrala, Witold Jurczyk, Adrian Maciejewski, Radoslaw Zalewski, Magdalena Witt, Jerzy Robert Ladny, Lukasz Szarpak
BACKGROUND: Sudden cardiac arrest (SCA) is a frequent cause of death in the developed world. Early defibrillation, preferably within the first minutes of the incident, significantly increases survival rates. Accessible automated external defibrillators (AED) in public areas have been promoted for many years and several locations are equipped with these devices. AIM: The aim of the study was to assess real-life availability of AEDs and assess possible sources of delay...
November 23, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29168281/a-review-of-urban-impacts-on-avian-life-history-evolution-does-city-living-lead-to-slower-pace-of-life
#8
REVIEW
Tuul Sepp, Kevin J McGraw, Ants Kaasik, Mathieu Giraudeau
The concept of a pace-of-life syndrome describes inter- and intraspecific variation in several life-history traits along a slow-to-fast pace-of-life continuum, with long lifespans, low reproductive and metabolic rates, and elevated somatic defences at the slow end of the continuum and the opposite traits at the fast end. Pace-of-life can vary in relation to local environmental conditions (e.g. latitude, altitude), and here we propose that this variation may also occur along an anthropogenically modified environmental gradient...
November 23, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29168203/the-wisdom-of-networks-a-general-adaptation-and-learning-mechanism-of-complex-systems-the-network-core-triggers-fast-responses-to-known-stimuli-innovations-require-the-slow-network-periphery-and-are-encoded-by-core-remodeling
#9
REVIEW
Peter Csermely
I hypothesize that re-occurring prior experience of complex systems mobilizes a fast response, whose attractor is encoded by their strongly connected network core. In contrast, responses to novel stimuli are often slow and require the weakly connected network periphery. Upon repeated stimulus, peripheral network nodes remodel the network core that encodes the attractor of the new response. This "core-periphery learning" theory reviews and generalizes the heretofore fragmented knowledge on attractor formation by neural networks, periphery-driven innovation, and a number of recent reports on the adaptation of protein, neuronal, and social networks...
November 23, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/29168078/the-effect-of-hypergastrinemia-following-sleeve-gastrectomy-and-pantoprazole-on-type-2-diabetes-mellitus-and-beta-cell-mass-in-goto-kakizaki-rats
#10
E Grong, C Nord, I B Arbo, M Eriksson, B E Kulseng, U Ahlgren, R Mårvik
PURPOSE: Metabolic surgery alters the secretion of gastrointestinal hormones that influence glycemic control. Elevated gastrin has been suggested to benefit patients with type 2 diabetes and has been reported following sleeve gastrectomy in rats. The present study compares the effect of hypergastrinemia following sleeve gastrectomy with proton-pump inhibitor therapy on glycemic control and beta-cell mass in lean, diabetic animals. METHODS: Thirty-three diabetic Goto-Kakizaki rats were randomized into pantoprazole + sham operation (GK-PPI), sleeve gastrectomy (GK-SG) and vehicle + sham operation (GK-V)...
November 22, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29168051/efficient-conformational-ensemble-generation-of-protein-bound-peptides
#11
Yumeng Yan, Di Zhang, Sheng-You Huang
Conformation generation of protein-bound peptides is critical for the determination of protein-peptide complex structures. Despite significant progress in conformer generation of small molecules, few methods have been developed for modeling protein-bound peptide conformations. Here, we have developed a fast de novo peptide modeling algorithm, referred to as MODPEP, for conformational sampling of protein-bound peptides. Given a sequence, MODPEP builds the peptide 3D structure from scratch by assembling amino acids or helix fragments based on constructed rotamer and helix libraries...
November 22, 2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/29168011/pediatric-prolactinoma-initial-presentation-treatment-and-long-term-prognosis
#12
Anika Hoffmann, Sarah Adelmann, Kristin Lohle, Alexander Claviez, Hermann L Müller
Prolactinoma is a rare pituitary adenoma secreting prolactin. Studies on diagnostics, treatment, and prognosis in pediatric prolactinoma patients are rare. We analyzed clinical presentation, response to treatment, and prognosis of 27 pediatric prolactinoma patients (10 m/17 f. based on patients' records. Tumors included 6 microadenomas (tumor volume: median 0.2 cm(3), range 0.01-0.4 cm(3); serum prolactin at diagnosis: median 101 ng/ml, range 33-177 ng/ml), 15 macroadenomas (volume: median 3.3 cm(3), range 0...
November 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29168010/modulation-of-thalamocortical-oscillations-by-trip8b-an-auxiliary-subunit-for-hcn-channels
#13
Mehrnoush Zobeiri, Rahul Chaudhary, Maia Datunashvili, Robert J Heuermann, Annika Lüttjohann, Venu Narayanan, Sabine Balfanz, Patrick Meuth, Dane M Chetkovich, Hans-Christian Pape, Arnd Baumann, Gilles van Luijtelaar, Thomas Budde
Hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels have important functions in controlling neuronal excitability and generating rhythmic oscillatory activity. The role of tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) in regulation of hyperpolarization-activated inward current, I h, in the thalamocortical system and its functional relevance for the physiological thalamocortical oscillations were investigated. A significant decrease in I h current density, in both thalamocortical relay (TC) and cortical pyramidal neurons was found in TRIP8b-deficient mice (TRIP8b(-/-))...
November 22, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29167995/ultrasound-guided-placement-of-ventricular-catheters-in-first-time-pediatric-vp-shunt-surgery
#14
Marcel Kullmann, Marina Khachatryan, Martin Ulrich Schuhmann
PURPOSE: Ventriculo-peritoneal (VP) shunts are effective for treatment of hydrocephalus in all age groups; however, they are associated with complications, a common one being ventricular catheter (VC) obstruction. VC position is likely to influence VC survival; however, most VCs are positioned freehand without guidance. This paper describes the accuracy of ultrasound guidance for VC placement and the impact of tip location on VC occlusion rate. METHODS: This is a retrospective cohort study of hydrocephalic children with first-time VP shunt and ultrasound-guided VC placement...
November 22, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29167927/new-diagnostic-criteria-for-gestational-diabetes-mellitus-and-their-impact-on-the-number-of-diagnoses-and-pregnancy-outcomes
#15
Sarah H Koning, Jelmer J van Zanden, Klaas Hoogenberg, Helen L Lutgers, Alberdina W Klomp, Fleurisca J Korteweg, Aren J van Loon, Bruce H R Wolffenbuttel, Paul P van den Berg
AIMS/HYPOTHESIS: Detection and management of gestational diabetes mellitus (GDM) are crucial to reduce the risk of pregnancy-related complications for both mother and child. In 2013, the WHO adopted new diagnostic criteria for GDM to improve pregnancy outcomes. However, the evidence supporting these criteria is limited. Consequently, these new criteria have not yet been endorsed in the Netherlands. The aim of this study was to determine the impact of these criteria on the number of GDM diagnoses and pregnancy outcomes...
November 22, 2017: Diabetologia
https://www.readbyqxmd.com/read/29167814/data-for-the-optimization-of-conditions-for-meat-species-identification-using-ultra-fast-multiplex-direct-convection-pcr
#16
Kyung-Young Song, Hyun Jin Hwang, Jeong Hee Kim
This article contains data related to the research article entitled "Ultra-fast DNA-based multiplex convection PCR method for meat species identification with possible on-site applications" (Song et al., 2017 [1]). Direct PCR that does not require prior DNA extraction is critical for ultra-fast molecular detection of meat species. We successfully acquired DNA by swab sampling in Taq DNA polymerase buffer. To reduce DNA sample preparation time, proteinase K incubation (0.2 μg/mL) and heat inactivation times were decreased to 10 min and 1 min, respectively...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29167415/ticagrelor-leads-to-statin-induced-rhabdomyolysis-a-case-report
#17
Simone M Mrotzek, Tienush Rassaf, Matthias Totzeck
BACKGROUND Following acute coronary intervention in cardiology patients, the combined medical therapy with the platelet inhibitory drug ticagrelor and a statin medication (e.g., simvastatin) is recommended according to international guidelines. Yet combined therapeutic regimens have the potential of pharmacological interaction with both ticagrelor and simvastatin being metabolized by CYP3A4. Rhabdomyolysis is a known side-effect of statin therapy and combined therapy increases the susceptibility to this complication...
November 23, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29167059/dietary-total-animal-vegetable-calcium-and-type-2-diabetes-incidence-among-korean-adults-the-korean-multi-rural-communities-cohort-mrcohort
#18
J M Oh, H W Woo, M K Kim, Y-H Lee, D H Shin, M-H Shin, B Y Choi
BACKGROUND AND AIMS: Although a possible mechanism for developing type 2 diabetes in relation to calcium intake has been suggested, there is currently little epidemiological evidence on the association between dietary calcium and type 2 diabetes (T2D). This study aimed to evaluate the prospective association between dietary calcium and T2D incidence among adults 40 years of age or over, from the Multi-rural Communities Cohort (MRCohort), South Korea. METHODS AND RESULTS: In total, 8313 participants (3033 men and 5280 women) who did not have diabetes at baseline were recruited between 2005 and 2013...
October 13, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29166601/triple-function-of-synaptotagmin-7-ensures-efficiency-of-high-frequency-transmission-at-central-gabaergic-synapses
#19
Chong Chen, Rachel Satterfield, Samuel M Young, Peter Jonas
Synaptotagmin 7 (Syt7) is thought to be a Ca(2+) sensor that mediates asynchronous transmitter release and facilitation at synapses. However, Syt7 is strongly expressed in fast-spiking, parvalbumin-expressing GABAergic interneurons, and the output synapses of these neurons produce only minimal asynchronous release and show depression rather than facilitation. To resolve this apparent contradiction, we examined the effects of genetic elimination of Syt7 on synaptic transmission at the GABAergic basket cell (BC)-Purkinje cell (PC) synapse in cerebellum...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166547/chemical-metabolome-assay-by-high-resolution-orbitrap-mass-spectrometry-and-assessment-of-associated-antitumoral-activity-of-actinocephalus-divaricatus
#20
Ana C Zanatta, Angela Mari, Milena Masullo, Iracilda Zeppone Carlos, Wagner Vilegas, Sonia Piacente, Lourdes Campaner Dos Santos
RATIONALE: Actinocephalus divaricatus (Eriocaulaceae) is an important source of income for the rural communities as it is sold as an ornamental plant. To date, no investigation has been conducted concerning the chemical composition and biological studies of the aerial parts of A. divaricatus. METHODS: The methanolic extract of the aerial parts of this species was chemically characterized. We applied an analytical dereplication approach based on Liquid Chromatography coupled to High Resolution Orbitrap Mass Spectrometry in order to develop, identify and define rapidly the metabolite fingerprint of the aerial parts of A...
November 22, 2017: Rapid Communications in Mass Spectrometry: RCM
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