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https://www.readbyqxmd.com/read/28324999/surface-electromyography-based-muscle-fatigue-analysis-for-stroke-patients-at-different-brunnstrom-stages
#1
Yinjun Tu, Zhe Zhang, Xudong Gu, Qiang Fang
Muscle fatigue analysis has been an important topic in sport and rehabilitation medicine due to its role in muscle performance evaluation and pathology investigation. This paper proposes a surface electromyography (sEMG) based muscle fatigue analysis approach which was specifically designed for stroke rehabilitation applications. 14 stroke patients from 5 different Brunnstrom recovery stage groups were involved in the experiment and features including median frequency and mean power frequency were extracted from the collected sEMG samples for investigation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324618/thermogelling-chitosan-lactate-hydrogel-improves-functional-recovery-after-a-c2-spinal-cord-hemisection-in-rat
#2
Katarzyna Nawrotek, Tanguy Marqueste, Zofia Modrzejewska, Roman Zarzycki, Agnieszka Rusak, Patrick Decherchi
The present study was designed to provide an appropriate micro-environment for regenerating axotomized neurons and proliferating/migrating cells. Because of its intrinsic permissive properties, biocompatibility and biodegradability, we chose to evaluate the therapeutic effectiveness of a chitosan-based biopolymer. The biomaterial toxicity was measured through in vitro test based on fibroblast cell survival on thermogelling chitosan lactate hydrogel substrate and then polymer was implanted into a C2 hemisection of the rat spinal cord...
March 21, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28319881/40hz-auditory-steady-state-responses-in-patients-with-disorders-of-consciousness-correlation-between-phase-locking-index-and-coma-recovery-scale-revised-score
#3
Marek Binder, Urszula Górska, Inga Griskova-Bulanova
OBJECTIVE: We aimed to elucidate whether 40Hz auditory steady-state response (ASSR) could be sensitive to the state of patients with disorders of consciousness (DOC) as estimated with Coma Recovery Scale-Revised (CRS-R) diagnostic tool. METHODS: Fifteen DOC patients and 24 healthy controls took part in the study. The 40Hz click trains were used to evoke ASSRs. Mean evoked amplitude (EA) and phase-locking index (PLI) within 38-42Hz window were calculated for 100ms bins, starting from -200 to 700ms relative to stimulus onset...
February 28, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28315758/tat-pep-a-novel-blocker-of-pirb-enhances-the-recovery-of-cognitive-function-in-mice-after-transient-global-cerebral-ischemia
#4
Liya Li, Bin Deng, Shuang Li, Tao Jiang, Zhaoyang Xiao, Qiang Wang
Neuronal damage and axonal regeneration inhibition are the main reasons to poor functional recovery after ischemia. Nogo-A signals inhibit axon outgrowth through the PirB receptor after ischemic reperfusion injury in central nervous system. We use TAT-PEP, a novel protein which could pass through the blood brain barrier, to block the function of PirB and identify the long-term neurological and behavioral recovery after bilateral common carotid artery occlusion (BCCAO) in mice. We observed that TAT-PEP promoted neuron survival and inhibited neuronal apoptosis...
March 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28297672/identification-of-intrinsic-axon-growth-modulators-for-intact-cns-neurons-after-injury
#5
Kathren L Fink, Francesc López-Giráldez, In-Jung Kim, Stephen M Strittmatter, William B J Cafferty
Functional deficits persist after spinal cord injury (SCI) because axons in the adult mammalian central nervous system (CNS) fail to regenerate. However, modest levels of spontaneous functional recovery are typically observed after trauma and are thought to be mediated by the plasticity of intact circuitry. The mechanisms underlying intact circuit plasticity are not delineated. Here, we characterize the in vivo transcriptome of sprouting intact neurons from Ngr1 null mice after partial SCI. We identify the lysophosphatidic acid signaling modulators LPPR1 and LPAR1 as intrinsic axon growth modulators for intact corticospinal motor neurons after adjacent injury...
March 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28293254/multiple-uses-of-fibrin-sealant-for-nervous-system-treatment-following-injury-and-disease
#6
REVIEW
Natalia Perussi Biscola, Luciana Politti Cartarozzi, Suzana Ulian-Benitez, Roberta Barbizan, Mateus Vidigal Castro, Aline Barroso Spejo, Rui Seabra Ferreira, Benedito Barraviera, Alexandre Leite Rodrigues Oliveira
Lesions to the nervous system often produce hemorrhage and tissue loss that are difficult, if not impossible, to repair. Therefore, scar formation, inflammation and cavitation take place, expanding the lesion epicenter. This significantly worsens the patient conditions and impairment, increasing neuronal loss and glial reaction, which in turn further decreases the chances of a positive outcome. The possibility of using hemostatic substances that also function as a scaffold, such as the fibrin sealant, reduces surgical time and improve postoperative recovery...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28291185/efficacy-of-surgical-site-multimodal-drug-injection-following-operative-management-of-femoral-fractures-a-randomized-controlled-trial
#7
Daniel Koehler, J Lawrence Marsh, Matthew Karam, Catherine Fruehling, Michael Willey
BACKGROUND: Multimodal analgesia inclusive of periarticular injection with a local anesthetic agent has been rapidly assimilated, with demonstrated safety and efficacy, into the care of patients undergoing elective lower-extremity arthroplasty. The present study was performed to evaluate the efficacy and safety of a surgical-site, multimodal drug injection for postoperative pain control following operative management of femoral fractures. METHODS: There were 102 patients undergoing operative intervention (plate fixation, intramedullary device, or arthroplasty) for a broad range of femoral fracture patterns who were prospectively randomized either to receive an intraoperative, surgical-site injection into the superficial and deep tissues containing ropivacaine, epinephrine, and morphine or to receive no injection...
March 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28290150/extracellular-matrix-modulation-is-driven-by-experience-dependent-plasticity-during-stroke-recovery
#8
Miriana Jlenia Quattromani, Mathilde Pruvost, Carla Guerreiro, Fredrik Backlund, Elisabet Englund, Anders Aspberg, Tomasz Jaworski, Jakob Hakon, Karsten Ruscher, Leszek Kaczmarek, Denis Vivien, Tadeusz Wieloch
Following stroke, complete cellular death in the ischemic brain area may ensue, with remaining brain areas undergoing tissue remodelling to various degrees. Experience-dependent brain plasticity exerted through an enriched environment (EE) promotes remodelling after central nervous system injury, such as stroke. Post-stroke tissue reorganization is modulated by growth inhibitory molecules differentially expressed within the ischemic hemisphere, like chondroitin sulfate proteoglycans found in perineuronal nets (PNNs)...
March 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28281491/status-epilepticus-refractory-and-super-refractory
#9
REVIEW
Deepanshu Dubey, Jayantee Kalita, Usha K Misra
Status epilepticus (SE) is an important neurological emergency. It is defined as seizures lasting for 5 minutes or more or recurrent seizures without recovery of consciousness to baseline between the attacks. Refractory SE (RSE) is defined as SE persisting despite sufficient dose of benzodiazepines and at least one antiepileptic drug (AED), irrespective of time. Super refractory SE (SRSE) is defined as SE that continues for 24 hours or more after the use of anesthetic therapy, including cases that recur on weaning of the anesthestic agent...
2017: Neurology India
https://www.readbyqxmd.com/read/28278758/chondrotinase-abc-i-thermal-stability-is-enhanced-by-site-directed-mutagenesis-a-molecular-dynamic-simulations-approach
#10
Kowsar Bagherzadeh, Monireh Maleki, Abolfazl Golestani, Khosro Khajeh, Massoud Amanlou
Chondroitin sulfate proteoglycans (CSPGs) are potent inhibitors of growth in the adult central nervous system. Use of the enzyme chondroitinase ABC I (ChABC I) as a strategy to reduce CSPG inhibition in experimental models of spinal cord injury has led to observations of its remarkable capacity for repair. More importantly, ChABC therapy has been demonstrated to promote significant recovery of function to spinal injured animals. Despite this incomparable function of ChABC I, its clinical application has been limited because of its thermal instability as reported in the literature...
March 1, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28271646/two-treatment-cases-of-severe-fever-and-thrombocytopenia-syndrome-with-oral-ribavirin-and-plasma-exchange
#11
In Park, Hye In Kim, Ki Tae Kwon
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease. The primary symptoms associated with SFTS are fever, thrombocytopenia, leukopenia, nausea, and vomiting. Disease progression shows high mortality rate accompanied with multiple organ failure, bleeding tendency, and altered mentality. However, only supportive care has been the basis for the treatment of SFTS. We are reporting two patients who showed central nervous system manifestation, but cured them with ribavirin together with plasma exchange in an early state...
January 19, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28270745/chaperone-proteins-in-the-central-nervous-system-and-peripheral-nervous-system-after-nerve-injury
#12
REVIEW
Shalina S Ousman, Ariana Frederick, Erin-Mai F Lim
Injury to axons of the central nervous system (CNS) and the peripheral nervous system (PNS) is accompanied by the upregulation and downregulation of numerous molecules that are involved in mediating nerve repair, or in augmentation of the original damage. Promoting the functions of beneficial factors while reducing the properties of injurious agents determines whether regeneration and functional recovery ensues. A number of chaperone proteins display reduced or increased expression following CNS and PNS damage (crush, transection, contusion) where their roles have generally been found to be protective...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28255460/the-polarization-states-of-microglia-in-tbi-a-new-paradigm-for-pharmacological-intervention
#13
REVIEW
Hangzhe Xu, Zhijiang Wang, Jianru Li, Haijian Wu, Yucong Peng, Linfeng Fan, Jingyin Chen, Chi Gu, Feng Yan, Lin Wang, Gao Chen
Traumatic brain injury (TBI) is a serious medical and social problem worldwide. Because of the complex pathophysiological mechanisms of TBI, effective pharmacotherapy is still lacking. The microglial cells are resident tissue macrophages located in the brain and have two major polarization states, M1 phenotype and M2 phenotype, when activated. The M1 phenotype is related to the release of proinflammatory cytokines and secondary brain injury, while the M2 phenotype has been proved to be responsible for the release of anti-inflammation cytokines and for central nervous system (CNS) repair...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28251674/microglial-repopulation-resolves-inflammation-and-promotes-brain-recovery-after-injury
#14
Rachel A Rice, Jason Pham, Rafael J Lee, Allison R Najafi, Brian L West, Kim N Green
Microglia mediate chronic neuroinflammation following central nervous system (CNS) disease or injury, and in doing so, damage the local brain environment by impairing recovery and contributing to disease processes. Microglia are critically dependent on signaling through the colony-stimulating factor 1 receptor (CSF1R) and can be eliminated via administration of CSF1R inhibitors. Resolving chronic neuroinflammation represents a universal goal for CNS disorders, but long-term microglial elimination may not be amenable to clinical use...
March 2, 2017: Glia
https://www.readbyqxmd.com/read/28244236/concise-reviews-innate-and-adaptive-immune-recognition-of-allogeneic-and-xenogeneic-cell-transplants-in-the-central-nervous-system
#15
Chloé J Hoornaert, Debbie Le Blon, Alessandra Quarta, Jasmijn Daans, Herman Goossens, Zwi Berneman, Peter Ponsaerts
Over the last 30 years, numerous allogeneic and xenogeneic cell grafts have been transplanted into the central nervous system (CNS) of mice and men in an attempt to cure neurological diseases. In the early studies, human or porcine embryonic neural cells were grafted in the striatum of animals or patients in an attempt to replace lost neurons. Although the immune-privileged status of the brain as a recipient organ was widely accepted, it rapidly became evident that CNS-grafted allogeneic and xenogeneic cells could be recognized and rejected by the immune system, resulting in poor neural graft survival and limited functional recovery...
February 28, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28239998/effects-of-colostrum-serum-on-the-serotonergic-system-in-the-dorsal-raphe-nuclei-of-exercised-rats
#16
Jin-Hee Seo, Tae-Woon Kim, Chang-Ju Kim
Purpose: The central fatigue hypothesis suggests that exhaustion, or the maximum level of exercise, induces excessive stress and increases serotonin concentrations in the brain, which in turn decreases central nervous system (CNS) function and induces fatigue. Our aim was to determine the effects of colostrum serum on the serotonergic system in the dorsal raphe nuclei during exhaustive exercise. Methods: Animals were randomly divided into five groups: control, exercise, exercise and treatment with 50, 100, and 200 mg/kg of colostrum serum...
February 24, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28229840/-magnetic-resonance-imaging-conversion-predictors-of-clinically-isolated-syndrome-to-multiple-sclerosis
#17
REVIEW
Sara Peixoto, Pedro Abreu
INTRODUCTION: Clinically isolated syndrome may be the first manifestation of multiple sclerosis, a chronic demyelinating disease of the central nervous system, and it is defined by a single clinical episode suggestive of demyelination. However, patients with this syndrome, even with long term follow up, may not develop new symptoms or demyelinating lesions that fulfils multiple sclerosis diagnostic criteria. We reviewed, in clinically isolated syndrome, what are the best magnetic resonance imaging findings that may predict its conversion to multiple sclerosis...
November 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28229330/the-involvement-of-the-myelin-associated-inhibitors-and-their-receptors-in-cns-plasticity-and-injury
#18
REVIEW
Anthony G Boghdadi, Leon Teo, James A Bourne
The limited capacity for the central nervous system (CNS) to repair itself was first described over 100 years ago by Spanish neuroscientist Ramon Y. Cajal. However, the exact mechanisms underlying this failure in neuronal regeneration remain unclear and, as such, no effective therapeutics yet exist. Numerous studies have attempted to elucidate the biochemical and molecular mechanisms that inhibit neuronal repair with increasing evidence suggesting that several inhibitory factors and repulsive guidance cues active during development actually persist into adulthood and may be contributing to the inhibition of repair...
February 22, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28227338/surface-electromyography-based-muscle-fatigue-analysis-for-stroke-patients-at-different-brunnstrom-stages
#19
Yinjun Tu, Zhe Zhang, Xudong Gu, Qiang Fang, Yinjun Tu, Zhe Zhang, Xudong Gu, Qiang Fang, Qiang Fang, Zhe Zhang, Yinjun Tu, Xudong Gu
Muscle fatigue analysis has been an important topic in sport and rehabilitation medicine due to its role in muscle performance evaluation and pathology investigation. This paper proposes a surface electromyography (sEMG) based muscle fatigue analysis approach which was specifically designed for stroke rehabilitation applications. 14 stroke patients from 5 different Brunnstrom recovery stage groups were involved in the experiment and features including median frequency and mean power frequency were extracted from the collected sEMG samples for investigation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220718/the-big-imitator-strikes-again-a-case-report-of-neurosyphilis-in-a-patient-with-newly-diagnosed-hiv
#20
Sévérine de Bruijn, Chris Kenyon, Nicolas Léonard, Erika Vlieghe
BACKGROUND: Neurosyphilis is the result of an infection of the central nervous system caused by the spirochete Treponema pallidum. Its clinical presentation includes meningovascular syphilis, tabes dorsalis, and dementia paralytica, resulting in a wide range of symptoms such as psychosis, Parkinsonism, and depression. CASE REPORT: A 49-year-old male was admitted to a psychiatric hospital because of social withdrawal and self-neglect, indicative of a major depression...
February 21, 2017: Acta Clinica Belgica
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