keyword
https://read.qxmd.com/read/38428744/multiscale-entropy-in-a-10-minute-vigilance-task
#21
JOURNAL ARTICLE
L Jack Rhodes, Lorraine Borghetti, Megan B Morris
Research has shown multiscale entropy, brain signal behavior across time scales, to reliably increase at lower time scales with time-on-task fatigue. However, multiscale entropy has not been examined in short vigilance tasks (i.e., ≤ 10 min). Addressing this gap, we examine multiscale entropy during a 10-minute Psychomotor Vigilance Test (PVT). Thirty-four participants provided neural data while completing the PVT. We compared the first 2 min of the task to the 7th and 8th minutes to avoid end-spurt effects...
February 28, 2024: International Journal of Psychophysiology
https://read.qxmd.com/read/38426484/prevalence-and-associated-clinical-characteristics-of-walking-related-motor-cognitive-and-fatigability-in-progressive-multiple-sclerosis-baseline-results-from-the-cogex-study
#22
JOURNAL ARTICLE
Cintia Ramari, Mieke D'hooge, Ulrik Dalgas, Anthony Feinstein, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D Chiaravalloti, Gary R Cutter, John DeLuca, Rachel Farrell, Massimo Filippi, Jennifer Freeman, Matilde Inglese, Cecilia Meza, Robert W Motl, Maria A Rocca, Brian M Sandroff, Amber Salter, Daphne Kos, Peter Feys
BACKGROUND: People with progressive multiple sclerosis (PMS) present motor (eg, walking) and cognitive impairments, and report fatigue. Fatigue encompasses fatigability which is objectively measured by the capacity to sustain a motor or cognitive task. OBJECTIVE: To investigate the prevalence of walking and cognitive fatigability (CF) and the associated clinical characteristics in a large sample of PMS patients. METHODS: PMS patients (25-65 years old) were included from 11 sites (Europe and North America), having cognitive impairment (1...
March 1, 2024: Neurorehabilitation and Neural Repair
https://read.qxmd.com/read/38421838/an-adaptive-hammerstein-model-for-fes-induced-torque-prediction-based-on-variable-forgetting-factor-recursive-least-square-algorithm
#23
JOURNAL ARTICLE
Qinlian Yang, Yingqi Li, You Li, Manxu Zheng, Rong Song
Modeling the muscle response to functional electrical stimulation (FES) is an important step during model-based FES control system design. The Hammerstein structure is widely used in simulating this nonlinear biomechanical response. However, a fixed relationship cannot cope well with the time-varying property of muscles and muscle fatigue. In this paper, we proposed an adaptive Hammerstein model to predict ankle joint torque induced by electrical stimulation, which uses variable forgetting factor recursive least squares (VFFRLS) method to update the model parameters...
February 29, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://read.qxmd.com/read/38418482/single-dose-creatine-improves-cognitive-performance-and-induces-changes-in-cerebral-high-energy-phosphates-during-sleep-deprivation
#24
JOURNAL ARTICLE
Ali Gordji-Nejad, Andreas Matusch, Sophie Kleedörfer, Harshal Jayeshkumar Patel, Alexander Drzezga, David Elmenhorst, Ferdinand Binkofski, Andreas Bauer
The inverse effects of creatine supplementation and sleep deprivation on high energy phosphates, neural creatine, and cognitive performances suggest that creatine is a suitable candidate for reducing the negative effects of sleep deprivation. With this, the main obstacle is the limited exogenous uptake by the central nervous system (CNS), making creatine only effective over a long-term diet of weeks. Thus far, only repeated dosing of creatine over weeks has been studied, yielding detectable changes in CNS levels...
February 28, 2024: Scientific Reports
https://read.qxmd.com/read/38412926/cholestatic-liver-disease-leads-to-significant-adaptative-changes-in-neural-circuits-regulating-social-behavior-in-mice-to-enhance-sociability
#25
JOURNAL ARTICLE
Wagdi Almishri, Mohammed O Altonsy, Mark G Swain
BACKGROUND & AIMS: Cholestatic liver diseases (CLD) are commonly associated with behavioral changes, including social isolation, that negatively affects patient quality of life and remains unaltered by current therapies. It remains unclear whether CLD-associated social dysfunction stems from a direct effect on the brain, or from the psychological impact of CLD. The psychological component of disease is absent in animals, so we investigated the impact of CLD on social behavior and gene expression profiles in key social behavior-regulating brain regions in a mouse model...
February 25, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38404605/neuroplasticity-intervention-amygdala-and-insula-retraining-air-significantly-improves-overall-health-and-functioning-across-various-chronic-conditions
#26
JOURNAL ARTICLE
Alexandra J Bratty
Chronic conditions, sometimes referred to as functional somatic disorders, such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), and more recently, long COVID (LC), affect millions of people worldwide. Yet, after decades of research and testing, the etiology and treatment for many of these diseases is still unclear. Recently, a consortium of clinicians and researchers have proposed that while many different chronic conditions exist, the root cause of each may be a similar brain-body connection, as the brain responds to perceived biological threats and transmits danger signals to the body that manifest as somatic symptoms...
January 2024: Integrative Medicine
https://read.qxmd.com/read/38403602/-mental-fatigue-state-recognition-method-based-on-convolution-neural-network-and-long-short-term-memory
#27
JOURNAL ARTICLE
Hui Wang, Pin Zhang, Fenghu Jin, Baoyong Zhao, Qinbo Zeng, Wendong Xiao
The pace of modern life is accelerating, the pressure of life is gradually increasing, and the long-term accumulation of mental fatigue poses a threat to health. By analyzing physiological signals and parameters, this paper proposes a method that can identify the state of mental fatigue, which helps to maintain a healthy life. The method proposed in this paper is a new recognition method of psychological fatigue state of electrocardiogram signals based on convolutional neural network and long short-term memory...
February 25, 2024: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://read.qxmd.com/read/38403179/people-with-long-covid-and-me-cfs-exhibit-similarly-impaired-dexterity-and-bimanual-coordination-a-case-case-control-study
#28
JOURNAL ARTICLE
Nilihan E M Sanal-Hayes, Lawrence D Hayes, Marie Mclaughlin, Ethan C J Berry, Nicholas F Sculthorpe
PURPOSE: Dexterity and bimanual coordination had not previously been compared between people with long COVID and people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Therefore, this study determined dexterity and bimanual coordination in people with long COVID (∼16 month illness duration; n=21) and ME/CFS (∼16 year illness duration; n=20), versus age-matched healthy controls (n=20). METHODS: Dexterity, and bimanual coordination was determined using the Purdue pegboard test...
February 23, 2024: American Journal of Medicine
https://read.qxmd.com/read/38399023/application-of-microfracture-analysis-to-fatigue-fractures-in-materials-through-non-destructive-tests
#29
JOURNAL ARTICLE
Ulises Sánchez-Santana, Gerardo Presbítero-Espinosa, José María Quiroga-Arias
Fatigue fractures in materials are the main cause of approximately 80% of all material failures, and it is believed that such failures can be predicted and mathematically calculated in a reliable manner. It is possible to establish prediction modalities in cases of fatigue fractures according to three fundamental variables in fatigue, such as volume, number of fracture cycles, as well as applied stress, with the integration of Weibull constants (length characteristic). In this investigation, mechanical fatigue tests were carried out on specimens smaller than 4 mm2 , made of different industrial materials...
February 6, 2024: Materials
https://read.qxmd.com/read/38391760/revealing-the-complexity-of-fatigue-a-review-of-the-persistent-challenges-and-promises-of-artificial-intelligence
#30
REVIEW
Thorsten Rudroff
Part I reviews persistent challenges obstructing progress in understanding complex fatigue's biology. Difficulties quantifying subjective symptoms, mapping multi-factorial mechanisms, accounting for individual variation, enabling invasive sensing, overcoming research/funding insularity, and more are discussed. Part II explores how emerging artificial intelligence and machine and deep learning techniques can help address limitations through pattern recognition of complex physiological signatures as more objective biomarkers, predictive modeling to capture individual differences, consolidation of disjointed findings via data mining, and simulation to explore interventions...
February 19, 2024: Brain Sciences
https://read.qxmd.com/read/38382711/a-generative-adaptive-convolutional-neural-network-with-attention-mechanism-for-driver-fatigue-detection-with-class-imbalanced-and-insufficient-data
#31
JOURNAL ARTICLE
Le He, Li Zhang, Qiang Sun, XiangTian Lin
Over the past few years, fatigue driving has emerged as one of the main causes of traffic accidents, necessitating the development of driver fatigue detection systems. However, many existing methods involves tedious manual parameter tunings, a process that is both time-consuming and results in task-specific models. On the other hand, most of the researches on fatigue recognition are based on class-balanced and sufficient data, and effectively "mine" meaningful information from class-imbalanced and insufficient data for fatigue recognition is still a challenge...
February 19, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38373361/functions-and-mechanisms-of-adenosine-and-its-receptors-in-sleep-regulation
#32
REVIEW
Lishan Huang, Wenwen Zhu, Nanxi Li, Bin Zhang, Wenbin Dai, Sen Li, Houping Xu
Sleep is a natural and recurring state of life. Long-term insomnia can lead to physical and mental fatigue, inattention, memory loss, anxiety, depression and other symptoms, imposing immense public health and economic burden worldwide. The sleep and awakening regulation system is composed of many nerve nuclei and neurotransmitters in the brain, and it forms a neural network that interacts and restricts each other to regulate the occurrence and maintenance of sleep-wake. Adenosine (AD) is a neurotransmitter in the central nervous system and a driver of sleep...
February 7, 2024: Sleep Medicine
https://read.qxmd.com/read/38357304/a-real-world-disproportionality-analysis-of-mesalazine-data-mining-of-the-public-version-of-fda-adverse-event-reporting-system
#33
JOURNAL ARTICLE
Mingdi Liu, Liting Gu, Yuning Zhang, Honglan Zhou, Yishu Wang, Zhi-Xiang Xu
Background: Mesalazine, a preparation of 5-aminosalicylic acid, is a medication widely used in clinical practice as a first-line therapy in the treatment of mild and moderate inflammatory bowel disease. However, the long-term safety of mesalazine in large sample population was unknown. The current study was to assess mesalazine -related adverse events of real-world through data mining of the US Food and Drug Administration Adverse Event Reporting System (FAERS). Methods: Disproportionality analyses, including the reporting odds ratio (ROR), the proportional reporting ratio the Bayesian confidence propagation neural network and the multi-item gamma Poisson shrinker (MGPS) algorithms were employed to quantify the signals of mesalazine -associated AEs...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38355674/bifidobacterium-longum-1714-improves-sleep-quality-and-aspects-of-well-being-in-healthy-adults-a-randomized-double-blind-placebo-controlled-clinical-trial
#34
JOURNAL ARTICLE
Elaine Patterson, Hern Tze Tina Tan, David Groeger, Mark Andrews, Martin Buckley, Eileen F Murphy, John A Groeger
Stress and sleep are linked with overall well-being. Bifidobacterium longum 1714 has been shown to influence stress responses and modulate neural responses during social stress, and influence sleep quality during examination stress in healthy adults. Here, we explored the ability of this strain to alter sleep quality in adults using subjective and objective measures. Eighty-nine adults (18-45y) with impaired sleep quality assessed with the Pittsburgh Sleep Quality Index (PSQI) and with a global score ≥ 5 were randomized to receive B...
February 14, 2024: Scientific Reports
https://read.qxmd.com/read/38347175/multi-target-drugs-for-the-treatment-of-cognitive-impairment-and-fatigue-in-post-covid-syndrome-focus-on-ginkgo-biloba-and-rhodiola-rosea
#35
REVIEW
Juliane K Mueller, Walter E Müller
Cognitive impairment, depression and (mental) fatigue represent the most frequent neuropsychiatric symptoms of the post-COVID syndrome. Neuroinflammation, oxidative stress and mitochondrial dysfunction have been identified as common pathophysiological mechanisms underlying these symptoms. Attempts to treat post-COVID-associated cognitive impairment and fatigue with different drugs available for other diseases have not yet been successful. One probable explanation could be that these drugs work by one specific mechanism of action only and not in a broad multi-target way...
February 12, 2024: Journal of Neural Transmission
https://read.qxmd.com/read/38339993/influence-of-perceptual-load-on-attentional-orienting-in-post-stroke-fatigue-a-study-of-auditory-evoked-potentials
#36
JOURNAL ARTICLE
William De Doncker, Annapoorna Kuppuswamy
OBJECTIVE: Increasing perceptual load alters behavioral outcomes in post-stroke fatigue (PSF). While the effect of perceptual load on top-down attentional processing is known, here we investigate if increasing perceptual load modulates bottom-up attentional processing in a fatigue dependent manner. METHODS: In this cross-sectional observational study, in 29 first-time stroke survivors with no clinical depression, an auditory oddball task consisting of target, standard, and novel tones was performed in conditions of low and high perceptual load...
February 10, 2024: Neurorehabilitation and Neural Repair
https://read.qxmd.com/read/38329006/dexterity-in-the-acute-phase-of-stroke-impairments-and-neural-substrates
#37
JOURNAL ARTICLE
Eloïse Gerardin, Maxime Regnier, Laurence Dricot, Julien Lambert, Coralie van Ravestyn, Béatrice De Coene, Benoît Bihin, Påvel Lindberg, Yves Vandermeeren
BACKGROUND: Stroke can impair manual dexterity, leading to loss of independence following incomplete recovery. Enhancing our understanding of dexterity impairment may improve neurorehabilitation. OBJECTIVES: The study aimed to measure dexterity components in acute stroke patients with and without hand motor deficits, compare them to those of healthy controls (HC), and to explore the neural substrates involved in specific components of dexterity. METHODS: We used the Dextrain Manipulandum to quantify fine finger force control, finger selection accuracy, coactivation, and reaction time (RT)...
March 2024: Neurorehabilitation and Neural Repair
https://read.qxmd.com/read/38322807/i-like-therefore-i-can-and-i-can-therefore-i-like-the-role-of-self-efficacy-and-affect-in-active-inference-of-allostasis
#38
JOURNAL ARTICLE
Valery Krupnik
Active inference (AIF) is a theory of the behavior of information-processing open dynamic systems. It describes them as generative models (GM) generating inferences on the causes of sensory input they receive from their environment. Based on these inferences, GMs generate predictions about sensory input. The discrepancy between a prediction and the actual input results in prediction error. GMs then execute action policies predicted to minimize the prediction error. The free-energy principle provides a rationale for AIF by stipulating that information-processing open systems must constantly minimize their free energy (through suppressing the cumulative prediction error) to avoid decay...
2024: Frontiers in Neural Circuits
https://read.qxmd.com/read/38303088/outcome-of-severe-covid-19-spotlight-on-fatigue-fatigability-multidomain-complaints-and-pattern-of-cognitive-deficits-in-a-case-series-without-prior-brain-dysfunction-and-without-covid-19-related-stroke-and-or-cardiac-arrest
#39
JOURNAL ARTICLE
Valérie Beaud, Sonia Crottaz-Herbette, Vincent Dunet, Jean-François Knebel, Pierre-Alexandre Bart, Stephanie Clarke
BACKGROUND: Population-wide surveys and large-scale investigations highlighted the presence of cognitive deficits in the acute and postacute stages of severe COVID-19; a few studies documented their occurrence in cases without prior or COVID-19-related brain damage. The evolution of cognitive deficits in the latter population and their relationship to the post-COVID-19 fatigue syndrome are poorly understood. CASE PRESENTATION: We report the outcome at 12 months after severe COVID-19 involving an intensive care unit stay and mechanical ventilation in six (five Caucasian and one Asian) patients (age range: 53-71 years, mean age 61...
February 2, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38277703/nonlinear-spatio-temporal-filter-to-reduce-crosstalk-in-bipolar-electromyogram
#40
JOURNAL ARTICLE
Luca Mesin
The wide detection volume of surface electromyogram (EMG) makes it prone to crosstalk, i.e., the signal from other muscles than the target one. Removing this perturbation from bipolar recordings is an important open problem for many applications. 
Approach. An innovative nonlinear spatio-temporal filter is developed to estimate the EMG generated by the target muscle by processing noisy signals from two bipolar channels, placed over the target and the crosstalk muscle, respectively. The filter is trained on some calibration data and then can be applied on new signals...
January 26, 2024: Journal of Neural Engineering
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