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optical coherence tomographic angiography in diabetic

David A Salz, Talisa E de Carlo, Mehreen Adhi, Eric Moult, WhooJhon Choi, Caroline R Baumal, Andre J Witkin, Jay S Duker, James G Fujimoto, Nadia K Waheed
IMPORTANCE: Optical coherence tomographic angiography (OCTA) is a recently developed noninvasive imaging technique that can visualize the retinal and choroidal microvasculature without the injection of exogenous dyes. OBJECTIVE: To evaluate the potential clinical utility of OCTA using a prototype swept-source OCT (SS-OCT) device and compare it with fluorescein angiography (FA) for analysis of the retinal microvasculature in diabetic retinopathy. DESIGN, SETTING, AND PARTICIPANTS: Prospective, observational cross-sectional study conducted at a tertiary care academic retina practice from November 2013 through November 2014...
June 1, 2016: JAMA Ophthalmology
Liuna Jang, Carl P Herbort
Management of diabetic retinopathy should follow more strict and aggressive rules in patients at risk for severe acute renal impairment. Such patients should be identified and possibly prophylactically laser treated to avoid the severe consequences demonstrated in this case report. A 34-year-old type 2 diabetes patient with a stabilized diabetic retinopathy developed acute and severe retinal decompensation within weeks after acute renal failure complicated his chronic stable renal impairment. Fluorescein angiographic and optical coherence tomographic illustrations of the rapid evolution of the retinal condition are presented...
February 20, 2016: International Ophthalmology
Gabriel Coscas, Marco Lupidi, Florence Coscas
No abstract text is available yet for this article.
April 2016: JAMA Ophthalmology
Miao Zhang, Jie Wang, Alex D Pechauer, Thomas S Hwang, Simon S Gao, Liang Liu, Li Liu, Steven T Bailey, David J Wilson, David Huang, Yali Jia
This article provides an overview of advanced image processing for three dimensional (3D) optical coherence tomographic (OCT) angiography of macular diseases, including age-related macular degeneration (AMD) and diabetic retinopathy (DR). A fast automated retinal layers segmentation algorithm using directional graph search was introduced to separates 3D flow data into different layers in the presence of pathologies. Intelligent manual correction methods are also systematically addressed which can be done rapidly on a single frame and then automatically propagated to full 3D volume with accuracy better than 1 pixel...
December 1, 2015: Biomedical Optics Express
Daniela Ferrara, Nadia K Waheed, Jay S Duker
The body of knowledge of in vivo investigation of the choroid has been markedly enhanced by recent technological advances in optical coherence tomography (OCT). New insights elucidating the morphological features of the choriocapillaris and choroidal vasculature, in both physiological and pathological conditions, indicate that the choroid plays a pivotal role in many posterior segment diseases. In this article, a review of the histological characteristics of the choroid, which must be considered for the proper interpretation of in vivo imaging, is followed by a comprehensive discussion of fundamental principles of the current state-of-the-art in OCT, including cross-sectional OCT, en face OCT, and OCT angiography using both spectral domain OCT and swept source OCT technologies...
May 2016: Progress in Retinal and Eye Research
Armelle Cahuzac, Claire Scemama, Martine Mauget-Faÿsse, José-Alain Sahel, Benjamin Wolff
PURPOSE: To describe clinical, angiographic, and tomographic features and the therapeutic management of patients with retinal arterial macroaneurysm (RAM). METHODS: Retrospective analysis of patients diagnosed with RAM between January 2011 and September 2014 in Professor Sahel's Department of Ophthalmology, Rothschild Foundation. Retinal arterial macroaneurysms were classified as hemorrhagic, exudative, or quiescent. Patient demographics and comorbidities were recorded...
January 2016: European Journal of Ophthalmology
Taishi Yonetsu, Koji Kato, Shiro Uemura, Byeong-Keuk Kim, Yangsoo Jang, Soo-Jin Kang, Seung-Jung Park, Stephen Lee, Soo-Joong Kim, Haibo Jia, Rocco Vergallo, Farhad Abtahian, Jinwei Tian, Sining Hu, Robert W Yeh, Rahul Sakhuja, Iris McNulty, Hang Lee, Shaosong Zhang, Bo Yu, Tsunekazu Kakuta, Ik-Kyung Jang
BACKGROUND: The pathophysiological basis for the association between metabolic syndrome (MetS) and coronary artery disease is not well understood. We sought to characterize coronary plaques in patients with MetS by using optical coherence tomography. METHODS AND RESULTS: We identified 451 coronary plaques from 171 subjects who underwent optical coherence tomographic imaging in 3 coronary arteries. Subjects were divided into 3 groups: diabetes mellitus (DM, n=77), MetS (n=35), and a control group (C group, n=59) without DM or MetS...
September 2013: Circulation. Cardiovascular Imaging
Hatsuka Ito, Takahiro Horii, Kazuaki Nishijima, Atsushi Sakamoto, Masafumi Ota, Tomoaki Murakami, Nagahisa Yoshimura
PURPOSE: To evaluate the characteristics of microaneurysms seen on color fundus photography, fluorescein angiography, and spectral-domain optical coherence tomography in diabetic retinopathy. METHODS: One hundred and thirty-two consecutive eyes of 92 patients with diabetic retinopathy were reviewed retrospectively. The characteristics of microaneurysms, including capsular structure (ring sign), hyperreflective spots in the lumen, the retinal layers in which they are located, and adjacent cystoid spaces, were documented on spectral-domain optical coherence tomography as sectional images...
April 2013: Retina
Virgilio Lima-Gómez, Dulce Milagros Razo Blanco-Hernández
BACKGROUND: The tomographic cut-off point to detect macular edema uses an international reference of retinal thickness, which is greater than that in our population. We undertook this study to identify the expected value of central subfield mean thickness (CSMT) in Mexican patients with diabetes with clinically significant macular edema (CSME) and the proportion in which using only the tomographic cut-off point for clinical macular edema (>300 μm) could overlook the diagnosis. METHODS: We carried out an observational, analytical, crosssectional and prospective study...
March 2012: Cirugia y Cirujanos
Kazushige Tsunoda, Tomoaki Usui, Tetsuhisa Hatase, Satoshi Yamai, Kaoru Fujinami, Gen Hanazono, Kei Shinoda, Hisao Ohde, Masakazu Akahori, Takeshi Iwata, Yozo Miyake
PURPOSE: To report the clinical characteristics of occult macular dystrophy (OMD) in members of one family with a mutation of the RP1L1 gene. METHODS: Fourteen members with a p.Arg45Trp mutation in the RP1L1 gene were examined. The visual acuity, visual fields, fundus photographs, fluorescein angiograms, full-field electroretinograms, multifocal electroretinograms, and optical coherence tomographic images were examined. The clinical symptoms and signs and course of the disease were documented...
June 2012: Retina
Takahiro Horii, Tomoaki Murakami, Kazuaki Nishijima, Tadamichi Akagi, Akihito Uji, Naoko Arakawa, Yuki Muraoka, Nagahisa Yoshimura
OBJECTIVE: To study the characteristics of the reflectivity of the cystoid spaces and serous retinal detachment (SRD) on spectral-domain optical coherence tomography (SD-OCT) and the correlation with fluorescein findings in diabetic macular edema (DME). DESIGN: Retrospective, observational, cross-sectional study. PARTICIPANTS: Consecutive 134 eyes of 114 patients with clinically significant macular edema for whom SD-OCT and fluorescein angiography (FA) were performed on the same day...
May 2012: Ophthalmology
Ken Ogino, Tomoaki Murakami, Akitaka Tsujikawa, Kazuaki Miyamoto, Atsushi Sakamoto, Masafumi Ota, Nagahisa Yoshimura
PURPOSE: To evaluate the hyperreflective foci in branch retinal vein occlusion and central retinal vein occlusion depicted by spectral-domain optical coherence tomography (OCT). METHODS: Consecutive series of 73 eyes of 73 patients with retinal vein occlusion (58 branch retinal vein occlusion and 15 central retinal vein occlusion) who had Spectralis OCT images obtained were retrospectively reviewed, comparing color fundus photographs and fluorescein angiography...
January 2012: Retina
F Gómez-Ulla, M J Abraldes, E Basauri, M Fernández, A García-Layana, P Gili, J Montero, J Nadal, V Morales, M Saravia, F Cabrera, E Cervera
PURPOSE: A guidelines for the management of retinal vein occlusion is presented. This is necessary because at this moment several therapeutic alternatives have been developed although their role is not yet sufficiently defined. METHODS: Review of the literature for evidence published up to date. Relevant literature was identified and the level of evidence graded. Evidence was then assessed for consistency, applicability and clinical impact. The information was contrasted with those guides published in other countries...
September 2010: Archivos de la Sociedad Española de Oftalmología
Nobuyoshi Tanaka, Mitsuyasu Terashima, Sudhir Rathore, Tsuyoshi Itoh, Maoto Habara, Kenya Nasu, Masashi Kimura, Tatsuya Itoh, Yoshihisa Kinoshita, Mariko Ehara, Etsuo Tsuchikane, Keiko Asakura, Yasushi Asakura, Osamu Katoh, Takahiko Suzuki
OBJECTIVES: We performed this study to investigate with optical coherence tomography (OCT) the vascular response after sirolimus-eluting stent (SES) implantation between patients with and those without diabetes mellitus (DM). BACKGROUND: The difference in vascular response after SES implantation between patients with and those without DM has not been fully evaluated with OCT. METHODS: Optical coherence tomography was performed to examine 74 nonrestenotic SES implanted in 63 patients (32 with DM and 31 without DM) at 9 months after SES implantation...
October 2010: JACC. Cardiovascular Interventions
Takahiro Horii, Tomoaki Murakami, Kazuaki Nishijima, Atsushi Sakamoto, Masafumi Ota, Nagahisa Yoshimura
PURPOSE: To characterize microaneurysms in diabetic retinopathy (DR) depicted by spectral-domain optical coherence tomography (SD-OCT). DESIGN: Retrospective, observational case series. METHODS: We surveyed a consecutive series of 76 eyes from 60 patients with DR (22 mild nonproliferative diabetic retinopathy [NPDR]; 43 moderate NPDR; 9 severe NPDR; 2 proliferative diabetic retinopathy [PDR]) who underwent Spectralis OCT, fluorescein angiography (FA), and color fundus photography on the same day...
December 2010: American Journal of Ophthalmology
Małgorzata Figurska, Jacek Robaszkiewicz, Joanna Wierzbowska
OCT (opitcal coherence tomography), is a diagnostic method that enables the analysis of the retinal structures by means of high-resolution tomographic cross-sections of the retina. Whereas fluorescein and indocyanine angiography allow visualization of the retinal epithelium layer and chorioretinal vessels, OCT may help in diagnosing and monitoring the condition of many internal retinal layers. Ultrasound B-mode examinations have a resolution of about 150 microm while OCT provides a resolution of 10 microm. OCT makes it possible to detect and measure morphological changes, retinal thickness, retinal volume, thickness of retinal nerve fiber layer and various parameters of the optic disc...
2010: Klinika Oczna
Masafumi Ota, Kazuaki Nishijima, Atsushi Sakamoto, Tomoaki Murakami, Kohei Takayama, Takahiro Horii, Nagahisa Yoshimura
OBJECTIVE: To study morphologic changes of serous retinal detachment (SRD) and hyperreflective dots, which have been reported to be precursors of hard exudates, detectable in SRD using optical coherence tomography (OCT) to assess whether or not the OCT findings are correlated with the subfoveal deposition of hard exudates in patients with diabetic macular edema (DME) accompanied by SRD. DESIGN: Retrospective chart review. PARTICIPANTS: Twenty-eight eyes of 19 patients with DME accompanied by SRD...
October 2010: Ophthalmology
Ronald P Danis, Ingrid U Scott, Haijing Qin, Michael M Altaweel, Neil M Bressler, Susan B Bressler, David J Browning, Craig Kollman
BACKGROUND: Fluorescein angiography (FA) has been performed as part of the management of diabetic macular edema for many years. Its current role relative to the role of optical coherence tomography (OCT) is not well defined. PURPOSE: To evaluate the associations of FA features with visual acuity (VA) and with OCT and fundus photographic characteristics in eyes with diabetic macular edema. METHODS: In a clinical trial, conducted by the Diabetic Retinopathy Clinical Research Network to compare two methods of laser photocoagulation to treat diabetic macular edema, FA (film and digital), color photographs, OCT, and VA measurements were obtained at baseline and at 1 year...
November 2010: Retina
Suk Ho Byeon, Young Kwang Chu, Hun Lee, Sang Yeop Lee, Oh Woong Kwon
PURPOSE: To describe the morphologic features of ischemic diabetic maculopathy by high-resolution optical coherence tomography (OCT) and their correlation with the damaged foveal avascular zone (FAZ) on fluorescein angiography (FA). DESIGN: Observational case series. PARTICIPANTS: One hundred twenty-four eyes of 63 patients with diabetic retinopathy and acceptable FA and OCT images were studied. Twenty-three normal fellow eyes of 23 nondiabetic patients with unilateral acute central serous choroidopathy also were studied...
October 2009: Ophthalmology
Toshiyuki Oshitari, Noriko Asaumi, Masaru Watanabe, Ken Kumagai, Yoshinori Mitamura
We report a case of severe diabetic macular edema (DME) that developed after pioglitazone was used by a patient with proliferative diabetic retinopathy. A 30-year-old woman with poorly controlled type 2 diabetes mellitus visited our clinic in 2004. She had moderate pre-proliferative diabetic retinopathy OU. Because of the rapid progression of the diabetic retinopathy, she received pan-retinal photocoagulation in both eyes. Two weeks before using pioglitazone, her visual acuity was 0.9 OD and 0.7 OS. On October 2007, pioglitazone was prescribed by her internist because of poorly controlled blood glucose level...
2008: Vascular Health and Risk Management
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