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Kass, joseph

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https://www.readbyqxmd.com/read/28607779/thrombotic-microangiopathy-secondary-to-intravenous-abuse-of-opana%C3%A2-er
#1
Kamia Thakur, Vaibhav Agrawal, Ashley Kass, Lauren M Dimarino, R Patrick Dorion, Joseph Vadakara
Opana ER (oxymorphone) is an opioid drug available throughout the United States, and intravenous abuse of the crushed oral formulation has been associated with drug-induced thrombotic microangiopathy. In this abstract, we describe two young patients who lived together and used Opana ER intravenously. Both presented with microangiopathic hemolytic anemia that mimicked thrombotic thrombocytopenic purpura (TTP). Treating this condition poses a clinical challenge, as it is difficult to distinguish it from TTP. The role for plasma exchange is not clear but can be used while awaiting the results of the ADAMTS-13 activity, but ultimately supportive care with drug discontinuation is the recommended therapy of choice...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28375918/mitigating-cybersecurity-risks
#2
Rachel V Rose, Joseph S Kass
Cybersecurity issues and their impact on compliance with the Health Insurance Portability and Accountability Act (HIPAA) and the Health Information Technology for Economic and Clinical Health (HITECH) Act are becoming more of an enforcement focus for a variety of government agencies, including the US Department of Health and Human Services, the Federal Trade Commission, and the Department of Justice. In the case presented in this article, a nurse in a neurology practice opted to speak with a patient about human immunodeficiency virus testing procedures in a manner audible to others in the waiting room...
April 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28122905/burnout-career-satisfaction-and-well-being-among-us-neurologists-in-2016
#3
Neil A Busis, Tait D Shanafelt, Christopher M Keran, Kerry H Levin, Heidi B Schwarz, Jennifer R Molano, Thomas R Vidic, Joseph S Kass, Janis M Miyasaki, Jeff A Sloan, Terrence L Cascino
OBJECTIVE: To study prevalence of and factors that contribute to burnout, career satisfaction, and well-being in US neurologists. METHODS: A total of 4,127 US American Academy of Neurology member neurologists who had finished training were surveyed using validated measures of burnout, career satisfaction, and well-being from January 19 to March 21, 2016. RESULTS: Response rate was 40.5% (1,671 of 4,127). Average age of participants was 51 years, with 65...
February 21, 2017: Neurology
https://www.readbyqxmd.com/read/28041970/effect-of-advanced-age-on-peri-operative-outcomes-after-robotic-assisted-pulmonary-lobectomy-retrospective-analysis-of-287-consecutive-cases
#4
Kathryn S Kass, Frank O Velez-Cubian, Wei Wei Zhang, Kavian Toosi, Tawee Tanvetyanon, Kathryn L Rodriguez, Matthew R Thau, Joseph R Garrett, Carla C Moodie, Jacques P Fontaine, Eric M Toloza
OBJECTIVES: We investigated whether advanced age affects peri-operative outcomes after robotic-assisted pulmonary lobectomies. MATERIALS AND METHODS: We retrospectively analyzed patients who underwent robotic-assisted lobectomy by one surgeon over a 5-year period. Rates of postoperative complications were compared according to age group. Other outcomes, such as intraoperative complications, hospital length of stay (LOS), and in-hospital mortality, were also compared...
March 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27832476/neurological-and-neuropsychiatric-adverse-effects-of-dermatologic-medications
#5
REVIEW
Melinda Liu, Yuan Yu M Huang, Sylvia Hsu, Joseph S Kass
Severe, recalcitrant dermatologic conditions often require systemic treatment. Although efficacious, these medications have been associated with wide-ranging adverse reactions. Some are reversible, predictable, and either dose-dependent or treatment length-dependent, while others are unpredictable, irreversible, and potentially fatal. This review examines the neuropsychiatric adverse effects associated with US FDA-approved medications for treatment of the following dermatologic pathologies that typically require systemic therapy: autoimmune dermatoses, acne, psoriasis, and melanoma...
December 2016: CNS Drugs
https://www.readbyqxmd.com/read/27740995/legal-implications-of-physician-investment-and-ownership-in-health-care-enterprises
#6
Rachel V Rose, Joseph S Kass
This article presents a case in which a neurology group practice is considering investing in an imaging center that is owned by nonphysician investors with the aim of referring patients to this imaging center. The article reviews some important legal pitfalls in federal law that physicians must be aware of when considering such an investment and focuses on the general outlines of and exceptions to the Stark Law and the Federal Anti-Kickback Statute.
October 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27633644/bioethics-training-programmes-for-africa-evaluating-professional-and-bioethics-related-achievements-of-african-trainees-after-a-decade-of-fogarty-nih-investment
#7
Nancy E Kass, Joseph Ali, Kristina Hallez, Adnan A Hyder
OBJECTIVES: Our primary aim was to evaluate the impact of US National Institutes of Health (NIH)-funded bioethics training programmes (Fogarty bioethics training programmes, FBTPs) that trained individuals from Africa over the programme's first 10 years to examine changes between pretraining and post-training in individual achievement and to document any associations between individual, training programme and post-training accomplishments. DESIGN: We surveyed trainees from the 10 bioethics programmes funded by NIH Fogarty International Center from 2000 to 2011 that included African trainees...
September 15, 2016: BMJ Open
https://www.readbyqxmd.com/read/27342776/phosphodiesterase-5-inhibition-limits-doxorubicin-induced-heart-failure-by-attenuating-protein-kinase-g-i%C3%AE-oxidation
#8
Oleksandra Prysyazhna, Joseph Robert Burgoyne, Jenna Scotcher, Steven Grover, David Kass, Philip Eaton
Phosphodiesterase 5 (PDE5) inhibitors limit myocardial injury caused by stresses, including doxorubicin chemotherapy. cGMP binding to PKG Iα attenuates oxidant-induced disulfide formation. Because PDE5 inhibition elevates cGMP and protects from doxorubicin-induced injury, we reasoned that this may be because it limits PKG Iα disulfide formation. To investigate the role of PKG Iα disulfide dimerization in the development of apoptosis, doxorubicin-induced cardiomyopathy was compared in male wild type (WT) or disulfide-resistant C42S PKG Iα knock-in (KI) mice...
August 12, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27261690/palliative-care-in-multiple-sclerosis
#9
Ludo J Vanopdenbosch, David J Oliver, Joseph S Kass
Collaboration between the neurologist and palliative care team in the care of patients with severe demyelinating disease can result in improved patient care, and discussion of the complex ethical issues that arise when a patient expresses a wish to die may be rewarding for both patients and caregivers.
August 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27042911/ethical-considerations-for-the-use-of-next-generation-alzheimer-drugs-in-symptomatic-and-at-risk-patients
#10
Serge Gauthier, Pedro Rosa-Neto, Joseph S Kass
This article presents a case in which a patient with mild Alzheimer disease requests a prescription for a newly developed Alzheimer disease drug, after which the patient's daughter inquires about its potential usefulness as a prevention strategy for herself. The article discusses the physician's responsibility to balance the ethical principles of beneficence, nonmaleficence, and respect for patient autonomy when evaluating requests for medications from patients with neurocognitive disease as well as from asymptomatic but at-risk patients...
April 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27003002/medical-malpractice-reform-historical-approaches-alternative-models-and-communication-and-resolution-programs
#11
Joseph S Kass, Rachel V Rose
No abstract text is available yet for this article.
March 1, 2016: AMA Journal of Ethics
https://www.readbyqxmd.com/read/27002990/ethical-challenges-for-the-medical-expert-witness
#12
Joseph S Kass, Rachel V Rose
No abstract text is available yet for this article.
March 1, 2016: AMA Journal of Ethics
https://www.readbyqxmd.com/read/26966287/association-between-left-atrial-stiffness-index-and-atrial-fibrillation-recurrence-in-patients-undergoing-left-atrial-ablation
#13
Irfan M Khurram, Farhan Maqbool, Ronald D Berger, Joseph E Marine, David D Spragg, Hiroshi Ashikaga, Vadim Zipunnikov, David A Kass, Hugh Calkins, Saman Nazarian, Stefan L Zimmerman
BACKGROUND: Atrial fibrillation (AF) is associated with significant abnormalities of left atrial (LA) systolic and diastolic function. This study describes a novel measure, LA stiffness index, that estimates LA diastolic function and its association with clinical outcomes of catheter ablation. METHODS AND RESULTS: A total of 219 AF patients referred for ablation (59% paroxysmal, mean CHA2DS2VASc score 1.7 ± 1.4) were enrolled. Atrial pressure and volume loops were prepared from invasive pressure measures and cardiac magnetic resonance imaging volumetric data during sinus rhythm for all patients...
March 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/26914914/cutaneous-adverse-effects-of-neurologic-medications
#14
REVIEW
Eman Bahrani, Chloe E Nunneley, Sylvia Hsu, Joseph S Kass
Life-threatening and benign drug reactions occur frequently in the skin, affecting 8 % of the general population and 2-3 % of all hospitalized patients, emphasizing the need for physicians to effectively recognize and manage patients with drug-induced eruptions. Neurologic medications represent a vast array of drug classes with cutaneous side effects. Approximately 7 % of the United States (US) adult population is affected by adult-onset neurological disorders, reflecting a large number of patients on neurologic drug therapies...
March 2016: CNS Drugs
https://www.readbyqxmd.com/read/26718928/standard-operating-procedures-sops-for-evaluating-the-heart-in-preclinical-studies-of-duchenne-muscular-dystrophy
#15
LETTER
Dongsheng Duan, Jill A Rafael-Fortney, Alison Blain, David A Kass, Elizabeth M McNally, Joseph M Metzger, Christopher F Spurney, Kathi Kinnett
A recent working group meeting focused on contemporary cardiac issues in Duchenne muscular dystrophy (DMD) was hosted by the National Heart, Lung, and Blood Institute in collaboration with the Parent Project Muscular Dystrophy. An outcome of this meeting was to provide freely available detailed protocols for preclinical animal studies. The goal of these protocols is to improve the quality and reproducibility of cardiac preclinical studies aimed at developing new therapeutics for the prevention and treatment of DMD cardiomyopathy...
February 2016: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/26594648/exploring-institutional-research-ethics-systems-a-case-study-from-uganda
#16
Adnan A Hyder, Joseph Ali, Kristina Hallez, Tara White, Nelson K Sewankambo, Nancy E Kass
BACKGROUND: The increasing globalization of research drives a need for greater research ethics capacity in low resource countries. Several programs have attempted to expand research ethics capacity by training individuals, but few have focused on broader research ethics systems and institutions. This study describes and applies an institutional research ethics model to assess the institutional research ethics capacity of Makerere University College of Heath Sciences (MakCHS) in 2011. METHODS: Internal and external stakeholders conducted the assessment of MakCHS using the multidimensional Octagon framework...
2015: AJOB Empirical Bioethics
https://www.readbyqxmd.com/read/26209436/use-of-data-mining-at-the-food-and-drug-administration
#17
REVIEW
Hesha J Duggirala, Joseph M Tonning, Ella Smith, Roselie A Bright, John D Baker, Robert Ball, Carlos Bell, Susan J Bright-Ponte, Taxiarchis Botsis, Khaled Bouri, Marc Boyer, Keith Burkhart, G Steven Condrey, James J Chen, Stuart Chirtel, Ross W Filice, Henry Francis, Hongying Jiang, Jonathan Levine, David Martin, Taiye Oladipo, Rene O'Neill, Lee Anne M Palmer, Antonio Paredes, George Rochester, Deborah Sholtes, Ana Szarfman, Hui-Lee Wong, Zhiheng Xu, Taha Kass-Hout
OBJECTIVES: This article summarizes past and current data mining activities at the United States Food and Drug Administration (FDA). TARGET AUDIENCE: We address data miners in all sectors, anyone interested in the safety of products regulated by the FDA (predominantly medical products, food, veterinary products and nutrition, and tobacco products), and those interested in FDA activities. SCOPE: Topics include routine and developmental data mining activities, short descriptions of mined FDA data, advantages and challenges of data mining at the FDA, and future directions of data mining at the FDA...
March 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/26039864/patient-management-problem
#18
Joseph S Kass
No abstract text is available yet for this article.
June 2015: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/26039858/managing-outpatients-with-suicidal-or-homicidal-ideation
#19
REVIEW
Edward Poa, Joseph S Kass
Regardless of their specialty, physicians encounter various potential clinical emergencies in their outpatients that may require referring patients for the appropriate level and urgency of care. One such situation is the outpatient who presents with suicidal or homicidal ideation. In this circumstance, the physician is faced with performing a rapid evaluation of the symptoms, determining the acuity of the situation, and safely referring the patient to an appropriate level of care. Using case vignettes, this article reviews some of the immediate critical factors to consider in evaluating and managing the outpatient who expresses thoughts of suicide or homicide...
June 2015: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/25903201/acute-psychosis-in-a-pregnant-patient-with-graves-hyperthyroidism-and-anti-nmda-receptor-encephalitis
#20
Jesslyn Lu, Susan Samson, Joseph Kass, Nalini Ram
A previously healthy 36-year-old woman presented with visual hallucinations and acute psychosis manifested predominantly as hypersexuality. Laboratory testing demonstrated elevated free thyroxine levels, suppressed thyroid-stimulating hormone levels and presence of thyroid-stimulating immunoglobulin and thyroid peroxidase (TPO) antibodies consistent with Graves' disease. Despite achieving biochemical euthyroidism, she remained profoundly hypersexual. She did not respond to additional treatment with antipsychotics and corticosteroids, prompting further evaluation...
April 22, 2015: BMJ Case Reports
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