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"IgA nephropathy"

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https://www.readbyqxmd.com/read/27900938/calcitriol-in-the-treatment-of-iga-nephropathy-with-non-nephrotic-range-proteinuria-a-meta-analysis-of-randomized-controlled-trials%C3%A2
#1
Jin Deng, Xin Zheng, Hongping Xie, Lu Chen
OBJECTIVE: The aim of the present study was to investigate the efficacy and safety of calcitriol for treating Chinese patients with IgA nephropathy presenting as non-nephrotic range proteinuria, and a comprehensive meta-analysis was conducted using the related randomized controlled trials (RCTs). METHODS: We searched for RCTs of calcitriol for the treatment of IgA nephropathy in the CNKI, CBM, Cochrane Central Register of Controlled Trials, PUBMED, and EMBASE databases...
November 30, 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27900334/serum-levels-of-soluble-st2-and-il-10-are-associated-with-disease-severity-in-patients-with-iga-nephropathy
#2
Zhihui Zhang, Haifeng Wang, Li Zhang, Rebecca Crew, Nan Zhang, Xiaolei Liu, Yanfang Jiang
Background. The IL-33/ST2 axis is involved in humoral immune responses. Method. The concentrations of sera IL-33 and sST2 in 74 patients and 34 healthy controls (HC) were measured by ELISA. Clinical and laboratory data were examined. The potential association between sera IL-33 and sST2 and the clinical parameters in IgAN patients were analyzed. Results. No difference was discovered in IL-33 concentrations between IgAN patients and HCs; however, the sST2 were significantly higher in each stage of IgAN progression than in the HC...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27884116/kidney-disease-in-the-elderly-biopsy-based-data-from-14-renal-centers-in-poland
#3
Agnieszka Perkowska-Ptasinska, Dominika Deborska-Materkowska, Artur Bartczak, Tomasz Stompor, Tomasz Liberek, Barbara Bullo-Piontecka, Anna Wasinska, Agnieszka Serwacka, Marian Klinger, Jolanta Chyl, Michal Kuriga, Robert Malecki, Krzysztof Marczewski, Bogdan Hryniewicz, Tadeusz Gregorczyk, Monika Wieliczko, Stanislaw Niemczyk, Olga Rostkowska, Leszek Paczek, Magdalena Durlik
BACKGROUND: Longer life expectancy is associated with an increasing prevalence of kidney disease. Aging itself may cause renal damage, but the spectrum of kidney disorders that affect elderly patients is diverse. Few studies, mostly form US, Asia and West Europe found differences in the prevalence of some types of kidney diseases between elderly and younger patients based on renal biopsy findings, with varied proportion between glomerulopathies and arterionephrosclerosis as a dominant injury found...
November 25, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27876127/in-silico-prediction-of-specific-pathways-that-regulate-mesangial-cell-proliferation-in-iga-nephropathy
#4
Elham Sadat Mirfazeli, Sayed-Amir Marashi, Shiva Kalantari
IgA nephropathy is one of the most common forms of primary glomerulonephritis worldwide leading to end-stage renal disease. Proliferation of mesangial cells, i.e., the multifunctional cells located in the intracapillary region of glomeruli, after IgA- dominant immune deposition is the major histologic feature in IgA nephropathy. In spite of several studies on molecular basis of proliferation in these cells, specific pathways responsible for regulation of proliferation are still to be discovered. In this study, we predicted a specific signaling pathway started from transferrin receptor (TFRC), a specific IgA1 receptor on mesangial cells, toward a set of proliferation-related proteins...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27870872/aberrant-iga1-glycosylation-in-iga-nephropathy-a-systematic-review
#5
Qiang Sun, Zhenhai Zhang, Hong Zhang, Xiaorong Liu
OBJECTIVE: Galactose-deficient IgA1 was evaluated in patients with IgA nephropathy(IgAN) and controls in order to determine the predictive value of galactose-deficient IgA1 in cases of IgA nephropathy. METHODS: PubMed, EMBASE, Cochrane central register of controlled trials, CNKI, CBM disc, and VIP database were searched to identify eligible studies that evaluated a difference in aberrant IgA1 glycosylation in IgAN patients compared with controls. A meta-analysis was conducted to evaluate the impact of galactose-deficient IgA1(Gd-IgA1) levels in different groups...
2016: PloS One
https://www.readbyqxmd.com/read/27835947/successful-treatment-of-severe-pneumocystis-pneumonia-in-an-immunosuppressed-patient-using-caspofungin-combined-with-clindamycin-a-case-report-and-literature-review
#6
Hongjuan Li, Haoming Huang, Hangyong He
BACKGROUND: Pneumocystis jirovecii is responsible for Pneumocystis pneumonia (PCP), which occurs almost exclusively in immunocompromised individuals. Trimethoprim-sulfamethoxazole (TMP-SMZ) is regarded as the first-line treatment and prophylaxis for P. jirovecii infection, but the frequency of adverse reactions and newly emerged antibiotic resistance limit its use. CASE PRESENTATION: Ulcerations and hemorrhages involving the tongue were noted secondary to TMP-SMZ desensitization against PCP in a 46-year-old male who had previously been diagnosed with IgA nephropathy and sustained prolonged corticosteroid therapy...
November 11, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27821627/a-randomized-controlled-trial-of-rituximab-in-iga-nephropathy-with-proteinuria-and-renal-dysfunction
#7
Richard A Lafayette, Pietro A Canetta, Brad H Rovin, Gerald B Appel, Jan Novak, Karl A Nath, Sanjeev Sethi, James A Tumlin, Kshama Mehta, Marie Hogan, Stephen Erickson, Bruce A Julian, Nelson Leung, Felicity T Enders, Rhubell Brown, Barbora Knoppova, Stacy Hall, Fernando C Fervenza
IgA nephropathy frequently leads to progressive CKD. Although interest surrounds use of immunosuppressive agents added to standard therapy, several recent studies have questioned efficacy of these agents. Depleting antibody-producing B cells potentially offers a new therapy. In this open label, multicenter study conducted over 1-year follow-up, we randomized 34 adult patients with biopsy-proven IgA nephropathy and proteinuria >1 g/d, maintained on angiotensin-converting enzyme inhibitors or angiotensin receptor blockers with well controlled BP and eGFR<90 ml/min per 1...
November 7, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27821389/staphylococcus-infection-associated-gn-spectrum-of-iga-staining-and-prevalence-of-anca-in-a-single-center-cohort
#8
Anjali A Satoskar, Sarah Suleiman, Isabelle Ayoub, Jessica Hemminger, Samir Parikh, Sergey V Brodsky, Cherri Bott, Edward Calomeni, Gyongyi M Nadasdy, Brad Rovin, Lee Hebert, Tibor Nadasdy
BACKGROUND AND OBJECTIVES: Staphylococcus infection-associated GN (SAGN) is a well recognized disease entity, particularly because of the frequent IgA-dominant glomerular immunoglobulin staining on kidney biopsy. Biopsy features can resemble two other disease entities - primary IgA nephropathy and Henoch-Schönlein purpura nephritis - posing a diagnostic pitfall. This is clinically relevant because of the crucial difference in the therapeutic approach. The diagnosis of SAGN is further complicated by the variability in the degree of glomerular IgA (and C3) staining, the extent of electron dense immune-type deposits, and positive ANCA serology in some patients...
November 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27818460/different-expression-patterns-of-toll-like-receptor-mrnas-in-blood-mononuclear-cells-of-iga-nephropathy-and-iga-vasculitis-with-nephritis
#9
Ayano Saito, Atsushi Komatsuda, Hajime Kaga, Ryuta Sato, Masaru Togashi, Shin Okuyama, Hideki Wakui, Naoto Takahashi
Mucosal immunity may play a key role in IgA nephropathy (IgAN) and IgA vasculitis with nephritis (IgAVN). IgAVN is characterized by the presence of non-thrombocytopenic palpable purpura, associated with glomerulonephritis with IgA-dominant immune deposits. Recent studies have shown the up-regulation of Toll-like receptors (TLRs) in patients with IgAN or IgAVN. Among TLRs that mediate innate immune reactions, TLR2, TLR4, and TRL5 recognize bacterial components, while TLR3, TLR7, and TLR9 recognize viral components...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27815919/clinical-and-histological-risk-factors-for-progression-of-iga-nephropathy-an-update-in-children-young-and-adult-patients
#10
REVIEW
Rosanna Coppo
The identification of risk factors conditioning the progression of immunoglobulin (Ig)A nephropathy (IgAN) is needed due to the variability of the outcome of this renal disease, which ranges from remission or indolent course to progressive slow loss of renal function or rapidly evolving chronic renal failure. Based on the supposed individual risk of progression, the therapy is modulated from renin-angiotensin inhibitors to corticosteroids, alone or associated with other powerful but potentially harmful immunosuppressors...
November 4, 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/27812026/identification-of-g8969-a-in-mitochondrial-atp6-gene-that-severely-compromises-atp-synthase-function-in-a-patient-with-iga-nephropathy
#11
Shuzhen Wen, Katarzyna Niedzwiecka, Weiwei Zhao, Shutian Xu, Shaoshan Liang, Xiaodong Zhu, Honglang Xie, Déborah Tribouillard-Tanvier, Marie-France Giraud, Caihong Zeng, Alain Dautant, Róża Kucharczyk, Zhihong Liu, Jean-Paul di Rago, Huimei Chen
Here we elucidated the pathogenesis of a 14-year-old Chinese female who initially developed an isolated nephropathy followed by a complex clinical presentation with brain and muscle problems, which indicated that the disease process was possibly due to a mitochondrial dysfunction. Careful evaluation of renal biopsy samples revealed a decreased staining of cells induced by COX and NADH dehydrogenase activities, and a strong fragmentation of the mitochondrial network. These anomalies were due to the presence of a mutation in the mitochondrial ATP6 gene, G8969>A...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27811984/presence-of-streptococcus-mutans-strains-harbouring-the-cnm-gene-correlates-with-dental-caries-status-and-iga-nephropathy-conditions
#12
Taro Misaki, Shuhei Naka, Rina Hatakeyama, Akiko Fukunaga, Ryota Nomura, Taisuke Isozaki, Kazuhiko Nakano
Streptococcus mutans is a major pathogen of human dental caries. Strains harbouring the cnm gene, which encodes Cnm, a collagen-binding protein, contribute to the development of several systemic diseases. In this study, we analysed S. mutans strains isolated from the oral cavity of immunoglobulin (Ig)A nephropathy (IgAN) patients to determine potential relationships between cnm and caries status as well as IgAN conditions. Saliva specimens were collected from 109 IgAN patients and the cnm status of isolated S...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27806690/vitamin-d-deficiency-may-predict-a-poorer-outcome-of-iga-nephropathy
#13
Xiao-Hua Li, Xin-Ping Huang, Ling Pan, Cheng-Yu Wang, Ju Qin, Feng-Wei Nong, Yu-Zhen Luo, Yue Wu, Yu-Ming Huang, Xi Peng, Zhen-Hua Yang, Yun-Hua Liao
BACKGROUND: Experimental studies showed that 25-hydroxy-vitamin D [25(OH)D] deficiency (defined as 25-hydroxy-vitamin D < 15 ng/ml) has been associated with CKD progression. Patients with IgA nephropathy have an exceptionally high rate of severe 25(OH)D deficiency; however, it is not known whether this deficiency is a risk factor for progression of IgA nephropathy. We conducted this study to investigate the relationship between the plasma level of 25(OH)D and certain clinical parameters and renal histologic lesions in the patients with IgA nephropathy, and to evaluate whether the 25(OH)D level could be a good prognostic marker for IgA nephropathy progression...
November 2, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27806314/tlr1-polymorphism-rs4833095-as-a-risk-factor-for-iga-nephropathy-in-a-chinese-han-population-a-case-control-study
#14
Jie Gao, Linting Wei, Jiali Wei, Ganglian Yao, Li Wang, Meng Wang, Xinghan Liu, Cong Dai, Tianbo Jin, Zhijun Dai, Rongguo Fu
Toll-like receptors (TLRs) are a family of transmembrane receptors, and play a vital role in recognizing invading pathogens and activating innate immunity. Previous studies indicated that TLR1 single nucleotide polymorphisms (SNPs) might be associated with the risk of IgA nephropathy (IgAN). This study aims to investigate the relationship between TLR1 SNPs (rs4833095 and rs5743557) and IgAN in a Chinese Han population. This case-control study included 351 patients with IgAN and 310 healthy controls. Two SNPs (rs4833095 and rs5743557) of TLR1 were genotyped by Sequenom MassARRAY...
October 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27804980/novel-identified-associations-of-rgs1-and-rasgrp1-variants-in-iga-nephropathy
#15
Xu-Jie Zhou, Swapan K Nath, Yuan-Yuan Qi, Celi Sun, Ping Hou, Yue-Miao Zhang, Ji-Cheng Lv, Su-Fang Shi, Li-Jun Liu, Ruoyan Chen, Wanling Yang, Kevin Zhi He, Yanming Li, Hong Zhang
Known susceptibility loci together can only explain about 6-8% of the disease heritability of IgA nephropathy (IgAN), suggesting that there are still a large number of genetic variants remained to be discovered. We previously identified IgAN and systemic lupus erythematosus (SLE)/lupus nephritis (LN) shared many loci based on GWAS on Chinese populations. The more recent study with high-density genotyping of immune-related loci in individuals with Asian ancestry identified 10 new and 6 suggestive loci in SLE...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27802442/urinary-periostin-excretion-predicts-renal-outcome-in-iga-nephropathy
#16
Jin Ho Hwang, Jung Pyo Lee, Clara Tammy Kim, Seung Hee Yang, Jin Hyuk Kim, Jung Nam An, Kyung Chul Moon, Hajeong Lee, Yun Kyu Oh, Kwon Wook Joo, Dong Ki Kim, Yon Su Kim, Chun Soo Lim
BACKGROUND: Periostin is a matricellular protein and plays a vital role in tissue regeneration, fibrosis and wound healing. However, data about its significance in nephrology are limited. We investigated the correlation between urinary periostin excretion and its clinical significance including renal histologic findings and prognosis in IgA nephropathy (IgAN). METHODS: Of 399 patients from a glomerulonephritis cohort recruited between January 2009 and December 2014, 314 were enrolled...
November 1, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27799660/toward-noninvasive-diagnosis-of-iga-nephropathy-a-pilot-urinary-metabolomic-and-proteomic-study
#17
Michaela Neprasova, Dita Maixnerova, Jan Novak, Colin Reily, Bruce A Julian, Jan Boron, Petr Novotny, Miloslav Suchanek, Vladimir Tesar, Petr Kacer
IgA nephropathy is diagnosed by renal biopsy, an invasive procedure with a risk of significant complications. Noninvasive approaches are needed for possible diagnostic purposes and especially for monitoring disease activity or responses to treatment. In this pilot project, we assessed the utility of urine samples as source of biomarkers of IgA nephropathy. We used spot urine specimens from 19 healthy controls, 11 patients with IgA nephropathy, and 8 renal-disease controls collected on day of renal biopsy. Urine samples were analyzed using untargeted metabolomic and targeted proteomic analyses by several experimental techniques: liquid chromatography coupled with mass spectrometry, immunomagnetic isolation of target proteins coupled with quantitation by mass spectrometry, and protein arrays...
2016: Disease Markers
https://www.readbyqxmd.com/read/27796698/microrna-155-induced-t-lymphocyte-subgroup-drifting-in-iga-nephropathy
#18
Lichuan Yang, XiaoYan Zhang, Wei Peng, Mian Wei, Wei Qin
BACKGROUND: MicroRNA-155 (miR-155) is an important immune regulator of T lymphocyte subgroup balance and function. This study was performed to explore the relationships between miR-155 expression in peripheral blood mononuclear cells (PBMCs), T lymphocyte subgroups, T lymphocyte regulators, and the clinical manifestations of IgA nephropathy (IgAN) patients. METHODS: Sixty biopsy-proven IgAN patients and 25 healthy controls were included in this study. The expression of miRNAs in PBMCs was determined using a microRNA microarray and real-time RT-PCR...
October 31, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27795634/complete-remission-of-nephrotic-syndrome-and-acute-kidney-injury-in-crescentic-iga-nephropathy-role-of-mycophenolate-sodium
#19
D Bhandari, K D Jhaveri, H H Shah
Optimal therapy and prognosis of crescentic-IgA nephropathy (C-IgAN) are not known. Reported treatment options for C-IgAN include combination of corticosteroids and cyclophosphamide for 6 months. The role of mycophenolate sodium in C-IgAN is unknown. We report a case of C-IgAN that was successfully treated with combination immunosuppressive therapy.
September 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27788802/recurrent-iga-nephropathy-after-kidney-transplantation
#20
S Nijim, V Vujjini, S Alasfar, X Luo, B Orandi, C Delp, N M Desai, R A Montgomery, B E Lonze, N Alachkar
BACKGROUND: Immunoglobulin (Ig)A nephropathy is the most common primary glomerulonephritis worldwide, with a high recurrence rate after kidney transplantation. The aim of this study was to assess allograft survival, impact of recurrence on allograft function, and risk factors for post-transplant IgA recurrence. METHODS: We identified 104 patients with IgA nephropathy who underwent kidney transplantation at our center between 1993 and 2014. Fourteen patients underwent more than one allograft...
October 2016: Transplantation Proceedings
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