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Retina and vitreous

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https://www.readbyqxmd.com/read/29230977/scleral-buckling-using-a-non-contact-wide-angle-viewing-system-with-a-25-gauge-chandelier-endoilluminator
#1
Jaehyuck Jo, Byung Gil Moon, Joo Yong Lee
PURPOSE: To report the outcome of scleral buckling using a non-contact wide-angle viewing system with a 25-gauge chandelier endoilluminator. METHODS: Retrospective analyses of medical records were performed for 17 eyes of 16 patients with primary rhegmatogenous retinal detachment (RRD) without proliferative vitreoretinopathy who had undergone conventional scleral buckling with cryoretinopexy using the combination of a non-contact wide-angle viewing system and chandelier endoillumination...
December 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29227404/retina-the-journal-of-retinal-and-vitreous-diseases-2017-scientific-reviewers
#2
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Retina
https://www.readbyqxmd.com/read/29217260/ontogenesis-of-the-pinealo-retinal-neuronal-connection-in-albino-rats
#3
Ágnes Csáki, Viktória Vereczki, Ákos Lukáts, Zsolt Boldogkői, Anna Sebestyén, Zita Puskár, Katalin Köves
It was accepted for a long time that in mammals there is only retinofugal neuronal connection between the eye and the pineal body (PB). In our previous paper we described that nerve cells were present in hamster PB and these neurons could establish a reverse connection with the retina through a transsynaptic pathway. In adult albino rats neuronal perikarya were not found. In this present experiment it was examined whether the lack of these nerve cells in the PB of adult rats is the result of an apoptotic phenomenon or the lack of migration during the fetal period...
December 4, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29215307/effects-of-intravitreous-sodium-hydrosulfide-on-intraocular-pressure-and-retinopathy-in-ocular-hypertensive-rats
#4
M A Özer, Z Erişgin, S Özen, Y Tekelioğlu, S Takır
We investigated the possible neuroprotectant and intraocular pressure (IOP) lowering effects of intravitreous injection of sodium hydrosulfide (NaSH) in a rodent model of experimental glaucoma. Glaucoma currently is treated by controlling IOP using medications and/or surgery. These methods are not entirely adequate for all patients. We divided 24 rats into three groups. For the control group, the right eye was treated with intravitreous saline. For the glaucoma group, ocular hypertension was induced by photocoagulating three episcleral veins and the limbal plexus of the right eye using an argon laser, then saline was injected into the vitreous of these eyes during the third week...
December 7, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29211719/inhibition-of-soluble-epoxide-hydrolase-prevents-diabetic-retinopathy
#5
Jiong Hu, Sarah Dziumbla, Jihong Lin, Sofia-Iris Bibli, Sven Zukunft, Julian de Mos, Khader Awwad, Timo Frömel, Andreas Jungmann, Kavi Devraj, Zhixing Cheng, Liya Wang, Sascha Fauser, Charles G Eberhart, Akrit Sodhi, Bruce D Hammock, Stefan Liebner, Oliver J Müller, Clemens Glaubitz, Hans-Peter Hammes, Rüdiger Popp, Ingrid Fleming
Diabetic retinopathy is an important cause of blindness in adults, and is characterized by progressive loss of vascular cells and slow dissolution of inter-vascular junctions, which result in vascular leakage and retinal oedema. Later stages of the disease are characterized by inflammatory cell infiltration, tissue destruction and neovascularization. Here we identify soluble epoxide hydrolase (sEH) as a key enzyme that initiates pericyte loss and breakdown of endothelial barrier function by generating the diol 19,20-dihydroxydocosapentaenoic acid, derived from docosahexaenoic acid...
December 6, 2017: Nature
https://www.readbyqxmd.com/read/29210938/intraoperative-optical-coherence-tomography-imaging-of-the-peripheral-vitreous-and-retina
#6
Koichi Nishitsuka, Katsuhiro Nishi, Hiroyuki Namba, Yutaka Kaneko, Hidetoshi Yamashita
No abstract text is available yet for this article.
November 23, 2017: Retina
https://www.readbyqxmd.com/read/29202038/a-novel-biomimetic-nanosponge-protects-the-retina-from-the-enterococcus-faecalis-cytolysin
#7
Austin L LaGrow, Phillip S Coburn, Frederick C Miller, Craig Land, Salai Madhumathi Parkunan, Brian T Luk, Weiwei Gao, Liangfang Zhang, Michelle C Callegan
Intraocular infections are a potentially blinding complication of common ocular surgeries and traumatic eye injuries. Bacterial toxins synthesized in the eye can damage intraocular tissue, often resulting in poor visual outcomes. Enteroccocus faecalis causes blinding infections and is responsible for 8 to 17% of postoperative endophthalmitis cases. These infections are increasingly difficult to treat due to the emergence of multidrug-resistant strains. Virulent E. faecalis isolates secrete a pore-forming bicomponent cytolysin that contributes to retinal tissue damage during endophthalmitis...
November 2017: MSphere
https://www.readbyqxmd.com/read/29198810/short-duration-ocular-iontophoresis-of-ionizable-aciclovir-prodrugs-a-new-approach-to-treat-herpes-simplex-infections-in-the-anterior-and-posterior-segments-of-the-eye
#8
Yong Chen, Yogeshvar N Kalia
The objective was to investigate (trans)corneal and transscleral iontophoresis of biolabile amino acid ester prodrugs of aciclovir (ACV-X, X = Arg, Gly and Trp) as a means to increase ocular bioavailability of ACV. Prodrugs displayed tissue-dependent susceptibility to hydrolysis. Iontophoresis of ACV-Arg, ACV-Gly and ACV-Trp (5 mM, 0.5 mA/cm2) for 5 min followed by 55 min passive diffusion resulted in appreciable corneal deposition (21.5 ± 5.1, 14.1 ± 2.0 and 5.3 ± 0.6 nmol/cm2, respectively) and transcorneal permeation (13...
November 30, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29190238/longitudinal-changes-in-the-optic-nerve-head-and-retina-over-time-in-very-young-children-with-familial-exudative-vitreoretinopathy
#9
Jonghyun Lee, Mays A El-Dairi, Du Tran-Viet, Shwetha Mangalesh, Alexandria Dandridge, Kim Jiramongkolchai, Christian Viehland, Cynthia A Toth
PURPOSE: To explore vitreoretinal pathologies and their longitudinal changes visible on handheld optical coherence tomography (OCT) of young children with familial exudative vitreoretinopathy. METHODS: The authors retrospectively analyzed handheld OCT images for vitreoretinal interface and retinal abnormalities and optic nerve head (ONH) elevation. RESULTS: From 26 eyes of 16 children (mean age 32 months) with familial exudative vitreoretinopathy, 10 had ONH dragging on photographs, and in these, handheld OCT revealed temporal and anterior retinal displacement, prominent vitreopapillary adhesion or traction, and retinal nerve fiber layer thickening at ONH margins with adjacent retinal elevation...
November 22, 2017: Retina
https://www.readbyqxmd.com/read/29182404/evaluation-of-the-effect-of-everolimus-on-retinal-pigment-epithelial-cells-and-experimental-proliferative-vitreoretinopathy
#10
Hsi-Kung Kuo, Yi-Hao Chen, Yu-Hsia Kuo, Mu-Chan Ke, Ya-Chi Tseng, Pei-Chang Wu
PURPOSE: Failure of retinal detachment surgery is most commonly due to the development of proliferative vitreoretinopathy (PVR). Everolimus is an inhibitor of mammalian target of rapamycin (mTOR), and is available as oral tablets. In this study, we investigated the effect of everolimus on retinal pigment epithelial cells and modification of the severity of experimental PVR. METHODS: In our in vitro studies, primary culture of retinal pigment epithelium (RPE) cells was obtained from pigmented Rex rabbits...
November 28, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29180845/clinical-outcomes-of-endoscope-assisted-vitrectomy-for-treatment-of-rhegmatogenous-retinal-detachment
#11
Sho Yokoyama, Takashi Kojima, Toshio Mori, Taisuke Matsuda, Hiroyuki Sato, Norihiko Yoshida, Tatsushi Kaga, R Theodore Smith, Kazuo Ichikawa
Summary: We evaluated the clinical outcomes for ophthalmic endoscope-assisted vitrectomy in consecutive patients with uncomplicated rhegmatogenous retinal detachment (RRD). The primary success rate was 98.4% (125/127) without performing a posterior drainage retinotomy or using perfluorocarbon liquids (PFCL) for subretinal fluid drainage. Purpose: To investigate the clinical outcomes of endoscope-assisted vitrectomy in patients with uncomplicated RRD. Methods: We examined 127 eyes from consecutive patients who underwent repair of RRD by 23- or 25-gauge endoscope-assisted vitrectomy, with a minimum follow-up of 3 months...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29177891/plasma-levels-of-hypoxia-regulated-factors-in-patients-with-age-related-macular-degeneration
#12
Zygoula Ioanna, Schori Christian, Grimm Christian, Barthelmes Daniel
PURPOSE: Various hypoxia-related proteins are differentially expressed in the retina and secreted to the vitreous and/or aqueous humor of patients affected by dry or neovascular age-related macular degeneration (nAMD). To determine whether these conditions alter concentrations of cytokines also in the systemic circulation, we measured plasma levels of six hypoxia-related proteins. METHODS: Plasma was prepared from EDTA blood that was collected from patients affected by dry AMD (n = 5), nAMD (n = 11), proliferative diabetic retinopathy (PDR; n = 9), and patients with an epiretinal membrane (ERM; n = 11)...
November 25, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29176738/induction-of-immune-surveillance-of-the-dysmorphogenic-lens
#13
Caitlin M Logan, Caitlin J Bowen, A Sue Menko
The lens has been considered to be an immune privileged site not susceptible to the immune processes normally associated with tissue injury and wound repair. However, as greater insight into the immune surveillance process is gained, we have reevaluated the concept of immune privilege. Our studies using an N-cadherin lens-specific conditional knockout mouse, N-cadΔlens, show that loss of this cell-cell junctional protein leads to lens degeneration, necrosis and fibrotic change, postnatally. The degeneration of this tissue induces an immune response resulting in immune cells populating the lens that contribute to the development of fibrosis...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29176537/novel-surgical-technique-for-inducing-posterior-vitreous-detachment-during-pars-plana-vitrectomy-for-pediatric-patients-using-a-flexible-loop
#14
Linda A Cernichiaro-Espinosa, Audina M Berrocal
PURPOSE: Vitreoretinal surgical diseases in children are challenging because of the complex features of the vitreous, retina, and the interface between them. Posterior vitreous detachment is a crucial step during vitrectomy. To date, pharmacologic vitreolysis that liquefies the vitreous and disrupts the posterior hyaloid attachment to the retina has been studied. However, there are reports of unexplained adverse effects. We describe a case performed with a reproducible, safe and time-saving technique using a commercially available flexible loop for posterior vitreous detachment induction in a pediatric patient...
November 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29176526/macular-hole-formation-after-pars-plana-vitrectomy-for-primary-vitreoretinal-lymphoma
#15
Masatoshi Haruta, Chikako Taguchi, Ryoji Yamakawa
PURPOSE: To report a case of primary vitreoretinal lymphoma in which a macular hole developed after a diagnostic pars plana vitrectomy. METHODS: A retrospective interventional case report. RESULTS: A 65-year-old woman presented with worsening vision in the left eye. Fundus examination showed vitreous haze and multifocal, yellow-white infiltrates in the retina and under the retinal pigment epithelium in the left eye. She underwent a diagnostic pars plana vitrectomy in that eye...
November 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29175499/visualization-of-porcine-eye-anatomy-by-x-ray-microtomography
#16
Bartosz Leszczyński, Paulina Sojka-Leszczyńska, Dorota Wojtysiak, Andrzej Wróbel, Roman Pędrys
The aim of our study is to obtain, as accurately as possible, porcine ocular tissue visualization using microtomography (micro-CT) method. We propose image contrast enhancement by different staining procedures with combination of micro-CT scanning. Porcine eye globes were investigated with Bruker-SkyScan 1172 micro-CT. We used 4F1G and Bouin's as sample fixation solutions and tincture of iodine, 100% Lugol, phosphotungstic acid and 1% osmium tetroxide solutions for staining. Quantitative and qualitative analysis was performed based on micro-CT reconstruction images histograms and 3D volume rendering models of investigated samples...
November 22, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29165409/-mo-dified-scleral-buckling-for-additional-fixation-of-the-retina-with-endovitreal-magnetic-implant-experimental-study
#17
E G Kazimirova, V V Shiryaev, P V Lyskin, E Yu Kramarenko
Scleral buckling (SB) has been regaining its popularity in the treatment of retinal detachments. On large clinical material, it has been proved to be the technique of choice in phakic patients with retinal detachment of moderate severity. A combined procedure that incorporates features of episcleral as well as intravitreal surgeries has also become widely used. Aim - to investigate the prospects for increasing technical potential of SB, particularly, to investigate the possibility of additional atraumatic mechanical fixation of the retina from within the vitreous cavity...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29165406/-the-significance-of-fibroblasts-in-experimental-modeling-of-proliferative-vitreoretinopathy
#18
I P Khoroshilova-Maslova, N L Leparskaya, E A Vorotelyak, A V Vasiliev
AIM: to investigate the role of heterogeneous fibroblasts in the development of epiretinal membrane in eyes with modeled proliferative vitreoretinopathy. MATERIAL AND METHODS: The material for investigation were 6 eyes of 3 Chinchilla rabbits. Suspended fibroblasts (fibroblasts of the human skin - 200000 cells in 0.1 ml) were injected into the vitreous cavity via the pars plana. The animals were followed up for 1 month and then made out of the experiment. The eyes were enucleated and fixed in 10% neutral buffered formalin for routine histological examination...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29164803/preclinical-evaluation-and-optimization-of-a-cell-therapy-using-human-cord-blood-derived-endothelial-colony-forming-cells-for-ischemic-retinopathies
#19
Emma Reid, Jasenka Guduric-Fuchs, Christina L O'Neill, Lynsey-Dawn Allen, Sarah E J Chambers, Alan W Stitt, Reinhold J Medina
Cell therapy using endothelial progenitors holds promise for vascular repair in ischemic retinopathies. Using a well-defined subpopulation of human cord blood-derived endothelial progenitors known as endothelial colony-forming cells (ECFCs), we have evaluated essential requirements for further development of this cell therapy targeting the ischemic retina, including dose response, delivery route, and toxicity. First, to evaluate therapeutic efficacy relating to cell dose, ECFCs were injected into the vitreous of mice with oxygen-induced retinopathy...
November 22, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29157443/a-benchmark-study-of-automated-intra-retinal-cyst-segmentation-algorithms-using-optical-coherence-tomography-b-scans
#20
G N Girish, V A Anima, Abhishek R Kothari, P V Sudeep, Sohini Roychowdhury, Jeny Rajan
(BACKGROUND AND OBJECTIVES): Retinal cysts are formed by accumulation of fluid in the retina caused by leakages from inflammation or vitreous fractures. Analysis of the retinal cystic spaces holds significance in detection and treatment of several ocular diseases like age-related macular degeneration, diabetic macular edema etc. Thus, segmentation of intra-retinal cysts and quantification of cystic spaces are vital for retinal pathology and severity detection. In the recent years, automated segmentation of intra-retinal cysts using optical coherence tomography B-scans has gained significant importance in the field of retinal image analysis...
January 2018: Computer Methods and Programs in Biomedicine
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