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Retina and vitreous

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https://www.readbyqxmd.com/read/29655781/the-hyperopic-effect-of-narrow-band-long-wavelength-light-in-tree-shrews-increases-non-linearly-with-duration
#1
Alexander H Ward, Thomas T Norton, Carrie E Huisingh, Timothy J Gawne
During postnatal refractive development, an emmetropization mechanism uses refractive error to modulate the growth rate of the eye. Hyperopia (image focused behind the retina) produces what has been described as "GO" signaling that increases growth. Myopia (image focused in front of the retina) produces "STOP" signaling that slows growth. The interaction between GO and STOP conditions is non-linear; brief daily exposure to STOP counteracts long periods of GO. In young tree shrews, long-wavelength (red) light, presented 14 h per day, also appears to produce STOP signals...
April 12, 2018: Vision Research
https://www.readbyqxmd.com/read/29643808/innovative-nanoparticles-enhance-n-palmitoylethanolamide-intraocular-delivery
#2
Carmelo Puglia, Paolo Blasi, Carmine Ostacolo, Eduardo Sommella, Claudio Bucolo, Chiara B M Platania, Giovanni L Romano, Federica Geraci, Filippo Drago, Debora Santonocito, Barbara Albertini, Pietro Campiglia, Giovanni Puglisi, Rosario Pignatello
Nanostructured lipid carriers (NLCs) loaded with palmitoylethanolamide (PEA) were formulated with the aim to enhance ocular bioavailability of PEA, particularly to the back of the eye. Technological characterization (e.g., size, charge) of NLC loaded with PEA formulation (PEA-NLC) was performed, and NLC morphology was characterized by electron microscopy. Ocular pharmacokinetic study, after topical administration of the formulation, was carried out in rabbit eye. Ultra-high performance liquid chromatography tandem mass spectrometry analysis was carried out to detect PEA levels in ocular tissues...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29643781/two-cases-of-rhegmatogenous-retinal-detachment-associated-with-asteroid-hyalosis
#3
Yoshitaka Okuda, Keigo Kakurai, Takaki Sato, Seita Morishita, Masanori Fukumoto, Ryohsuke Kohmoto, Mai Takagi, Takatoshi Kobayashi, Teruyo Kida, Tsunehiko Ikeda
Background: To report two cases of rhegmatogenous retinal detachment (RRD) associated with asteroid hyalosis (AH). Case Presentation: Two patients presented with RRD originating from a flap tear. Case 1 involved a 62-year-old male who was found to have bullous RRD in his left eye originating from a flap tear. During vitreous surgery, a thick vitreous cortex was found to have strongly adhered to the entire retinal surface, from the center to the periphery. A bimanual method was then used in conjunction with the vitrectomy to create an artificial posterior vitreous detachment...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29643775/case-report-of-a-family-affected-by-stickler-syndrome-in-which-rhegmatogenous-retinal-detachment-occurred-in-five-eyes-of-three-siblings
#4
Daisaku Kimura, Takaki Sato, Shou Oosuka, Ryohsuke Kohmoto, Masanori Fukumoto, Masashi Mimura, Kensuke Tajiri, Takatoshi Kobayashi, Teruyo Kida, Tsunehiko Ikeda
Purpose: Stickler syndrome is an autosomal dominant inherited disorder that is well known to be highly associated with the development of rhegmatogenous retinal detachment. In this study, we report the case of a family affected by Stickler syndrome in which rhegmatogenous retinal detachment developed in 5 eyes of 3 siblings. Case Series: For treatment, we performed vitreous surgery on 1 eye of the eldest son, and bilateral scleral buckling surgery on the 2 younger children...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29643027/-purtscher-like-retinopathy-associated-with-antibiotic-anaphylaxis
#5
Zhi-Xuan Huang, Zhi-Bing Zeng, Zhu-Ping Xu
We report a case of an 18-year-old woman with systemic antibiotic anaphylaxis who presented anasarca and bilateral visual loss two weeks after the intravenous use of pazufloxacin. Ancillary fundus tests revealed bilateral cotton-wool spots, Purtscher flecken, edema, and retinal arteriolar occlusion around the optic disc. After pulse corticosteroid, administration of anti-anaphylactic agent, and general support therapy for one month, the patient showed a favorable change, with the symptoms lessened or free systemically, except the continuous aggravation of fundus ischemic change...
March 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29625461/allogeneic-ipsc-derived-rpe-cell-graft-failure-following-transplantation-into-the-subretinal-space-in-nonhuman-primates
#6
Trevor J McGill, Jonathan Stoddard, Lauren M Renner, Ilhem Messaoudi, Kapil Bharti, Shoukhrat Mitalipov, Andreas Lauer, David J Wilson, Martha Neuringer
Purpose: To characterize the intraocular immune response following transplantation of iPS-derived allogeneic RPE cells into the subretinal space of non-immune-suppressed rhesus macaques. Methods: GFP-labeled allogeneic iPS-derived RPE cells were transplanted into the subretinal space of one eye (n = 6), and into the contralateral eye 1 day to 4 weeks later, using a two-stage transretinal and transscleral approach. Retinas were examined pre- and post-surgery by color fundus photography, fundus autofluorescence, and optical coherence tomography (OCT) imaging...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29623721/evaluation-of-ocular-perforation-during-retrobulbar-block-using-high-resolution-spectral-domain-optical-coherence-tomography-and-optical-coherence-tomography-angiography
#7
Stanislao Rizzo, Ruggero Tartaro, Lucia Finocchio, Andrea Giorni, Daniela Bacherini, Alfonso Savastano
INTRODUCTION: This article reports a case of ocular perforation during a retrobulbar block in a patient who underwent scleral buckle for retinal detachment. METHODS: Sterile air was immediately injected into the vitreous cavity to restore intraocular pressure and the scleral buckle operation was quickly finished. One week later, a laser retinopexy was performed on the two retinal holes that were outside the foveal area. After 6 months, spectral domain-optical coherence tomography and optical coherence tomography angiography were performed on the perforated wall centered on the exit hole area...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29608907/m-to-l-cone-ratios-determine-eye-sizes-and-baseline-refractions-in-chickens
#8
Sandra Gisbert, Frank Schaeffel
Following a hypothesis raised by M. and J. Neitz, Seattle, we have tested whether the abundance and the ratio of Long wavelength-sensitive (L) to Middle wavelength-sensitive (M) cones may affect eye size and development of myopia in the chicken. Fourteen chickens were treated with frosted plastic diffusers in front of one eye on day 10 post-hatching for a period of 7 days to induce deprivation myopia. Ocular dimensions were measured by A-scan ultrasonography at the beginning and at the end of the treatment and development of refractive state was tracked using infrared photorefraction...
March 30, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29600187/endoscopy-assisted-vitrectomy-in-the-anterior-vitreous
#9
REVIEW
Yong-Zhen Yu, Yu-Ping Zou, Xiu-Lan Zou
Endoscopy-assisted ocular surgery is a relatively old technique that is increasingly being recognized for its application in cases of vitreoretinal disease. This technique is especially useful when both the vitreous and retina are difficult to access because of media opacity, a small pupil, or a microcornea. In this context, the anterior vitreous is often difficult to dissect because of its complex pathological changes. This article reviews the common anatomical features and pathologies that are observed in the anterior vitreous, as well as the applications and indications of endoscopy-assisted vitrectomy in the anterior vitreous...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29597134/hyaluronic-acid-coated-albumin-nanoparticles-for-targeted-peptide-delivery-in-the-treatment-of-retinal-ischaemia
#10
Di Huang, Ying-Shan Chen, Colin R Green, Ilva D Rupenthal
Recent studies have shown that Connexin43 mimetic peptide (Cx43 MP) can prevent secondary damage following retinal ischaemic and inflammatory disorders by blocking uncontrolled Cx43 hemichannel opening. However, limitations in peptide stability and the presence of various intraocular barriers limit efficient retinal delivery in the clinical setting. The present study aimed to achieve targeted and sustained peptide delivery to the retina by encapsulating Cx43 MP into hyaluronic acid (HA) coated albumin nanoparticles (NPs)...
March 20, 2018: Biomaterials
https://www.readbyqxmd.com/read/29596552/yield-techniques-and-complications-of-transvitreal-and-transscleral-biopsies-in-small-uveal-melanoma
#11
Ryan Sangwoo Kim, Patricia Chevez-Barrios, Mukul Divatia, Maria Eugenia Bretana, Bin Teh, Amy Claire Schefler
Importance: Intraoperative adequacy check of biopsy samples can lead to a higher biopsy yield rate, and subsequent genomic analysis can provide patients with valuable prognostic information. Objectives: To examine the yield rates for transscleral and transvitreal fine-needle aspiration biopsies of small uveal melanoma less than 3.6 mm in apical height and to discuss techniques that would maximize yield rates and minimize complications. Design, Setting, and Participants: A retrospective, consecutive observational case series was conducted from January 29, 2013, to May 23, 2017, at Retina Consultants of Houston and Houston Methodist Hospital among 44 patients with uveal melanoma of the ciliary body or choroid...
March 29, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29592777/an-intraocular-micro-light-emitting-diode-device-for-endo-illumination-during-pars-plana-vitrectomy
#12
Philipp S Koelbl, Christian Lingenfelder, Christoph W Spraul, Juergen Kampmeier, Frank Hj Koch, Yong Keun Kim, Martin Hessling
PURPOSE: Development of a new, fiber-free, single-use endo-illuminator for pars plana vitrectomy as a replacement for fiber-based systems with external light sources. The hand-guided intraocularly placed white micro light-emitting diode is evaluated for its illumination properties and potential photochemical and thermal hazards. METHODS: A micro light-emitting diode was used to develop a single-use intraocular illumination system. The light-source-on-tip device was implemented in a prototype with 23G trocar compatible outer diameter of 0...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29584759/anti-inflammatory-cytokine-and-angiogenic-factors-levels-in-vitreous-samples-of-diabetic-retinopathy-patients
#13
Teresa Tsai, Sandra Kuehn, Nikolaos Tsiampalis, Minh-Khoa Vu, Vinodh Kakkassery, Gesa Stute, H Burkhard Dick, Stephanie C Joachim
Evaluation of cytokines in patients with diabetic retinopathy (DR) is important for the identification of future additive or alternative treatment options. Therefore, vitreous samples were obtained from patients with DR and patients with macular hole or macular pucker (control group) during 23-gauge-vitrectomy (n = 17/group). The levels of three pro-inflammatory (IL-1ß, IL-6, IFN-γ) and pleiotropic cytokines (IL-2, IL-4, IL-13) as well as VEGF, VEGF-A, and PGF were measured using an enzyme linked immunosorbent assay (ELISA)...
2018: PloS One
https://www.readbyqxmd.com/read/29584529/characterization-and-pharmacokinetics-of-triamcinolone-acetonide-loaded-liposomes-topical-formulations-for-vitreoretinal-drug-delivery
#14
Juan C Altamirano-Vallejo, Jose Navarro-Partida, Alejandro Gonzalez-De la Rosa, Jane H Hsiao, Jose S Olguín-Gutierrez, Ana C Gonzalez-Villegas, Brian C Keller, Lourdes Bouzo-Lopez, Arturo Santos
PURPOSE: To achieve a safer alternative to intravitreal injection of corticosteroids, we developed and characterized triamcinolone acetonide-loaded liposomes formulations (TA-LFs) to be used topically for vitreoretinal drug delivery. METHODS: Four different 0.2% TA-LFs (TA-LF1 to TA-LF4) were generated and submitted to physicochemical characterization. Posteriorly, an ex vivo diffusion assay was performed using rabbit corneas as membranes. Finally, concentrations of triamcinolone acetonide (TA) were determined by high-performance liquid chromatography in ocular tissues from New Zealand white rabbits after multiple topical doses of TA-LF2 (6 times per day, 14 days)...
March 27, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29580956/the-use-of-miltefosine-in-the-management-of-refractory-acanthamoeba-keratitis
#15
Shokufeh Tavassoli, Miranda Buckle, Derek Tole, Peter Chiodini, Kieren Darcy
Acanthamoeba keratitis (AK) is a sight threatening infection most commonly affecting contact lens wearers. The authors report a case of intractable A.polyphaga and A.castellanii, with extensive intraocular spread, managed using oral miltefosine. A 59-year old male contact lens wearer was referred to the tertiary corneal service at Bristol Eye Hospital. Vision was hand movements on the left and 6/6 on the right. Clinical examination was consistent with left AK (confirmed by corneal scrape). Management included biguanide (polyhexamethylene biguanide (PHMB) 0...
March 23, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29560370/acute-vitreoretinal-trauma-and-inflammation-after-traumatic-brain-injury-in-mice
#16
Lucy P Evans, Elizabeth A Newell, MaryAnn Mahajan, Stephen H Tsang, Polly J Ferguson, Jolonda Mahoney, Christopher D Hue, Edward W Vogel, Barclay Morrison, Ottavio Arancio, Russell Nichols, Alexander G Bassuk, Vinit B Mahajan
Objective: Limited attention has been given to ocular injuries associated with traumatic brain injury (TBI). The retina is an extension of the central nervous system and evaluation of ocular damage may offer a less-invasive approach to gauge TBI severity and response to treatment. We aim to characterize acute changes in the mouse eye after exposure to two different models of TBI to assess the utility of eye damage as a surrogate to brain injury. Methods: A model of blast TBI (bTBI) using a shock tube was compared to a lateral fluid percussion injury model (LFPI) using fluid pressure applied directly to the brain...
March 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29552665/hemorrhagic-choroidal-melanoma
#17
Patrick Oellers, Natalie Wolkow, Frederick A Jakobiec, Ivana K Kim
Purpose: To demonstrate the clinical pathologic correlation in a hemorrhagic choroidal melanoma. Observations: A 52 year old patient presented with a large choroidal mass associated with vitreous and retinal hemorrhage. The eye was enucleated and histopathology demonstrated epithelioid-type MART1 positive tumor cells consistent with choroidal melanoma. The tumor had broken through Bruch's membrane, which led to localized vascular compression with bleeding into the subretinal space, retina and vitreous...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29543556/seasonal-hyperacute-panuveitis-in-nepal-a-review-over-40-years-of-surveillance
#18
Madan Upadhyay, Ranju Kharel Sitaula, Bharat Shrestha, Bhaiya Khanal, Bishnu Psd Upadhyay, Jeevan B Sherchand, Prakash Ghimire
PURPOSE: This review aims to provide a detailed update in Seasonal hypercute panuveitis (SHAPU) which is a blinding disease of unknown etiology reported only from Nepal, occurring every odd year since 1975 predominantly in children. METHODS: Data sources were literature reviewed using PubMed, Medline, and ISI Databases (since 1975 to late 2017). Search items included SHAPU, seasonal endophthalmitis, hypopyon uveitis, caterpillar induced uveitis alone or in combination with white moth, panuveitis, and review...
March 15, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29543200/-evaluation-of-yag-laser-vitreolysis-effectiveness-based-on-quantitative-characterization-of-vitreous-floaters
#19
V A Shaimova, T B Shaimov, R B Shaimov, A Yu Galin, Zh A Goloshchapova, P K Ryzhkov, A V Fomin
PURPOSE: To develop methods for evaluating effectiveness of YAG-laser vitreolysis of vitreous floaters. MATERIAL AND METHODS: The study included 144 patients (173 eyes) who had underwent YAG-laser vitreolysis and were under observation from 01.09.16 to 31.01.18. The patients were 34 to 86 years old (mean age 62.7±10.2 years), 28 (19.4%) patients were male, 116 (80.6%) - female. All patients underwent standard and additional examination: ultrasonography (Accutome B-scan plus, U...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29528887/localization-of-macular-crystals-associated-with-chronic-retinal-detachment-to-the-posterior-hyaloid-using-spectral-domain-optical-coherence-tomography
#20
Elizabeth A Atchison, Timothy P Flood
PURPOSE: To present a case of crystalline retinopathy associated with chronic retinal detachment and localize the macular crystals using spectral domain optical coherence tomography. METHODS: Case Report. RESULTS: A 37-year-old man with previously treated chronic retinal detachment presented with normal vision and crystalline maculopathy. Spectral domain optical coherence tomography localized the macular crystals to the posterior hyaloid membrane and on the internal limiting membrane, but not within the retina...
March 8, 2018: Retinal Cases & Brief Reports
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