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https://www.readbyqxmd.com/read/28102300/neural-correlates-of-speech-segregation-based-on-formant-frequencies-of-adjacent-vowels
#1
Claude Alain, Jessica S Arsenault, Linda Garami, Gavin M Bidelman, Joel S Snyder
The neural substrates by which speech sounds are perceptually segregated into distinct streams are poorly understood. Here, we recorded high-density scalp event-related potentials (ERPs) while participants were presented with a cyclic pattern of three vowel sounds (/ee/-/ae/-/ee/). Each trial consisted of an adaptation sequence, which could have either a small, intermediate, or large difference in first formant (Δf1) as well as a test sequence, in which Δf1 was always intermediate. For the adaptation sequence, participants tended to hear two streams ("streaming") when Δf1 was intermediate or large compared to when it was small...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28076920/effectiveness-of-impact-ability-to-improve-safety-and-self-advocacy-skills-in-students-with-disabilities-follow-up-study
#2
Eileen M Dryden, Jeffrey Desmarais, Lisa Arsenault
BACKGROUND: Research shows that individuals with disabilities are more likely to experience abuse than their peers without disabilities. Yet, few evidenced-based abuse prevention interventions exist. This study examines whether positive outcomes identified previously in an evaluation of IMPACT:Ability were maintained 1 year later. METHODS: A survey measuring safety and self-advocacy knowledge, confidence, and behaviors among special education high-school students was administered 12 months post-training...
February 2017: Journal of School Health
https://www.readbyqxmd.com/read/28069359/monitoring-equity-in-vaccination-coverage-a-systematic-analysis-of-demographic-and-health-surveys-from-45-gavi-supported-countries
#3
Catherine Arsenault, Sam Harper, Arijit Nandi, José M Mendoza Rodríguez, Peter M Hansen, Mira Johri
OBJECTIVES: (1) To conduct a systematic analysis of inequalities in childhood vaccination coverage in Gavi-supported countries; (2) to comparatively assess alternative measurement approaches and how they may affect cross-country comparisons of the level of inequalities. METHODS: Using the most recent Demographic and Health Surveys (2005-2014) in 45 Gavi-supported countries, we measured inequalities in vaccination coverage across seven dimensions of social stratification and of vulnerability to poor health outcomes...
January 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28064154/impact-of-left-ventricular-remodelling-patterns-on-outcomes-in-patients-with-aortic-stenosis
#4
Romain Capoulade, Marie-Annick Clavel, Florent Le Ven, Abdellaziz Dahou, Christophe Thébault, Lionel Tastet, Mylène Shen, Marie Arsenault, Élisabeth Bédard, Jonathan Beaudoin, Kim O'Connor, Mathieu Bernier, Jean G Dumesnil, Philippe Pibarot
AIMS: The objective of this study was to examine the association between the different patterns of left ventricular (LV) remodelling/hypertrophy on all-cause and cardiovascular mortality in patients with aortic stenosis (AS). METHODS AND RESULTS: In total, 747 consecutive patients (69 ± 14 years, 57% men) with AS and preserved LV ejection fraction were included in this study. According to LV mass index and relative wall thickness, patients were classified into four LV patterns: normal, concentric remodelling (CR), concentric hypertrophy (CH), and eccentric hypertrophy (EH)...
January 6, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28040289/two-year-outcomes-after-percutaneous-coronary-intervention-of-calcified-lesions-with-drug-eluting-stents
#5
Philippe Généreux, Björn Redfors, Bernhard Witzenbichler, Marie-Pier Arsenault, Giora Weisz, Thomas D Stuckey, Michael J Rinaldi, Franz-Josef Neumann, D Christopher Metzger, Timothy D Henry, David A Cox, Peter L Duffy, Ernest L Mazzaferri, Dominic P Francese, Guillaume Marquis-Gravel, Gary S Mintz, Ajay J Kirtane, Akiko Maehara, Roxana Mehran, Gregg W Stone
BACKGROUND: Percutaneous coronary intervention (PCI) of lesions with coronary arterial calcification (CAC) is common and has been historically associated with an increased risk of adverse events. Whether the association between target lesion calcification (CAC) and outcomes differ across drug-eluting stent generation or between patients with high vs. low residual platelet reactivity (PR) remains unknown. We assessed the association of CAC with adverse ischemic and bleeding events among patients undergoing contemporary PCI with drug-eluting stents (DES)...
December 26, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28030378/does-lifestyle-contribute-to-disease-severity-in-patients-with-inherited-lipid-disorders
#6
Benoit J Arsenault, Nicolas Perrot, Patrick Couture
PURPOSE OF REVIEW: Patients with familial hypercholesterolemia, familial combined hyperlipidemia and hyperlipoprotein(a) are at high cardiovascular risk. Increasing evidence suggest that lifestyle-related risk factors such as physical inactivity, and poor diet quality could influence cardiovascular risk in these patients. Our objective is to review the evidence that supports the role of lifestyle-related factors in the prediction of cardiovascular risk in patients with inherited lipid disorders...
December 24, 2016: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28009652/positive-and-negative-affect-is-related-to-experiencing-chest-pain-during-exercise-induced-myocardial-ischemia
#7
Philippe Stébenne, Simon L Bacon, Anthony Austin, Nicola J Paine, André Arsenault, Catherine Laurin, Bernard Meloche, Jennifer Gordon, Jocelyn Dupuis, Kim L Lavoie
OBJECTIVES: Silent myocardial ischemia is thought to be associated with worse cardiovascular outcomes due to a lack of perception of pain cues that initiate treatment seeking. Negative affect (NA) has been associated with increased pain reporting and positive affect (PA) with decreased pain reporting, but these psychological factors have not been examined within the context of myocardial ischemia. This study evaluated the associations between PA, NA, and chest pain reporting in patients with and without ischemia during exercise testing...
December 22, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27998826/ideal-cardiovascular-health-influences-cardiovascular-disease-risk-associated-with-high-lipoprotein-a-levels-and-genotype-the-epic-norfolk-prospective-population-study
#8
Nicolas Perrot, Rutger Verbeek, Manjinder Sandhu, S Matthijs Boekholdt, G Kees Hovingh, Nicholas J Wareham, Kay-Tee Khaw, Benoit J Arsenault
BACKGROUND AND AIMS: Lipoprotein(a) (Lp[a]) is a strong genetic risk factor for cardiovascular disease (CVD). The American Heart Association has prioritised seven cardiovascular health metrics to reduce the burden of CVD: body mass index, healthy diet, physical activity, smoking status, blood pressure, diabetes and cholesterol levels (together also known as ideal cardiovascular health). Our objective was to determine if individuals with high Lp(a) levels could derive cardiovascular benefits if characterized by ideal cardiovascular health...
November 11, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27969743/tct-38-paravalvular-regurgitation-regression-and-impact-on-1-year-outcomes-after-transcatheter-aortic-valve-replacement-with-the-sapien-3-transcatheter-valve
#9
Philippe Pibarot, Rebecca Hahn, Neil Weissman, Marie Arsenault, Jonathan Beaudoin, Mathieu Bernier, Abdellaziz Dahou, Omar Khalique, Federico Asch, Oumhani Toubal, Jonathon Leipsic, Philipp Blanke, Feifan Zhang, Rupa Parvataneni, Howard Herrmann, Martin Leon, Vinod Thourani, Susheel Kodali
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27919352/impact-of-a-1-year-lifestyle-modification-program-on-plasma-lipoprotein-and-pcsk9-concentrations-in-patients-with-coronary-artery-disease
#10
Marjorie Boyer, Valérie Lévesque, Paul Poirier, André Marette, Patrick Mathieu, Jean-Pierre Després, Éric Larose, Benoit J Arsenault
BACKGROUND: Patients with coronary artery disease (CAD) are characterized by an impaired cardiometabolic risk profile including high levels of atherogenic apolipoprotein (apo) B-containing lipoprotein levels. Genetic studies have highlighted a critical role for proprotein convertase subtilisin/kexin type 9 (PCSK9) in lipoprotein metabolism and CAD risk. OBJECTIVE: To determine whether improving dietary quality and increasing physical activity levels improve parameters of the cardiometabolic risk profile such as plasma apoB and PCSK9 levels in patients with CAD...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27904236/influence-of-exercise-on-patients-with-guillain-barr%C3%A3-syndrome-a-systematic-review
#11
Nicholas Simatos Arsenault, Pierre-Olivier Vincent, Bai He Shen Yu, Robin Bastien, Aaron Sweeney
Purpose: To evaluate the effects of exercise interventions on improving physical outcomes in patients with Guillain-Barré syndrome (GBS). Methods: The PubMed database was searched for articles published up to and including February 2015. Randomized controlled trials (RCTs), case reports, and quasi-experimental and single-subject designs published in English-language, peer-reviewed journals that assessed the impact of physical exercise on patients with GBS were included; study quality was assessed using Sackett's rules of evidence...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27903326/characterizing-areas-of-potential-human-exposure-to-eastern-equine-encephalitis-virus-using-serological-and-clinical-data-from-horses
#12
J-P Rocheleau, J Arsenault, N H Ogden, L R Lindsay, M Drebot, P Michel
Eastern equine encephalitis (EEE) is a rare but severe emerging vector-borne disease affecting human and animal populations in the northeastern United States where it is endemic. Key knowledge gaps remain about the epidemiology of EEE virus (EEEV) in areas where its emergence has more recently been reported. In Eastern Canada, viral activity has been recorded in mosquitoes and horses throughout the 2000s but cases of EEEV in humans have not been reported so far. This study was designed to provide an assessment of possible EEEV human exposure by modelling environmental risk factors for EEEV in horses, identifying high-risk environments and mapping risk in the province of Quebec, Canada...
December 1, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27862827/comparison-of-radiation-exposure-during-transradial-diagnostic-coronary-angiography-with-single-or-multi-catheters-approach
#13
Guillaume Plourde, Eltigani Abdelaal, Jimmy MacHaalany, Goran Rimac, Yann Poirier, Jean Arsenault, Olivier Costerousse, Olivier F Bertrand
OBJECTIVE: To compare radiation exposure during transradial diagnostic coronary angiography (DCA) using standard single- or multi-catheters with different shapes. BACKGROUND: Transradial DCA can be performed using single- or multi-catheters to canulate left and right coronary ostia. To date, it remains unknown whether there are differences in radiation exposure between the two strategies. METHODS: From November 2012 to June 2014, 3,410 consecutive patients who underwent transradial DCA were recruited...
November 10, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27856457/carriers-of-the-pcsk9-r46l-variant-are-characterized-by-an-antiatherogenic-lipoprotein-profile-assessed-by-nuclear-magnetic-resonance-spectroscopy-brief-report
#14
Rutger Verbeek, Marjorie Boyer, S Matthijs Boekholdt, G Kees Hovingh, John J P Kastelein, Nicholas Wareham, Kay-Tee Khaw, Benoit J Arsenault
OBJECTIVE: Carriers of the PCSK9 (proprotein convertase subtilisin/kexin 9) R46L genetic variant (rs11591147) are characterized by low levels of low-density lipoprotein cholesterol and a decreased risk of cardiovascular disease. We studied the impact of the R46L variant on lipoprotein size and composition. APPROACH AND RESULTS: Lipoprotein size and composition were measured by nuclear magnetic resonance spectroscopy in 2373 participants of the EPIC (European Prospective Investigation into Cancer and Nutrition)-Norfolk study...
January 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27850762/1125-critical-care-observation-of-motor-activity-a-routine-bedside-exam-on-sicu-outcomes
#15
Sandra Muse, Colleen Arsenault, Tharusan Thevathasan, Annop Piriyapatsom, Karen Waak, Ulrich Schmidt, Matthias Eikermann
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27786253/synchronizing-stochastic-circadian-oscillators-in-single-cells-of-neurospora-crassa
#16
Zhaojie Deng, Sam Arsenault, Cristian Caranica, James Griffith, Taotao Zhu, Ahmad Al-Omari, Heinz-Bernd Schüttler, Jonathan Arnold, Leidong Mao
The synchronization of stochastic coupled oscillators is a central problem in physics and an emerging problem in biology, particularly in the context of circadian rhythms. Most measurements on the biological clock are made at the macroscopic level of millions of cells. Here measurements are made on the oscillators in single cells of the model fungal system, Neurospora crassa, with droplet microfluidics and the use of a fluorescent recorder hooked up to a promoter on a clock controlled gene-2 (ccg-2). The oscillators of individual cells are stochastic with a period near 21 hours (h), and using a stochastic clock network ensemble fitted by Markov Chain Monte Carlo implemented on general-purpose graphical processing units (or GPGPUs) we estimated that >94% of the variation in ccg-2 expression was stochastic (as opposed to experimental error)...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27770548/identification-of-small-molecule-phd2-zinc-finger-inhibitors-that-activate-hypoxia-inducible-factor
#17
Patrick R Arsenault, Daisheng Song, Marian Bergkamp, Andrew M Ravaschiere, Bradleigh E Navalsky, Paul M Lieberman, Frank S Lee
The prolyl hydroxylase domain (PHD) protein:hypoxia inducible factor (HIF) pathway is the main pathway by which changes in oxygen concentration are transduced to changes in gene expression. In mammals, there are three PHD paralogues, and PHD2 has emerged as a particularly critical one for regulating HIF target genes such as erythropoietin (EPO), which controls red cell mass and hematocrit. PHD2 is distinctive among the three PHDs in that it contains an N-terminal MYND-type zinc finger. We have proposed that this zinc finger binds a Pro-Xaa-Leu-Glu (PXLE) motif found in proteins of the HSP90 pathway to facilitate HIF-α hydroxylation...
December 14, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27763849/implementation-of-a-radon-measurement-protocol-and-its-communication-plan-by-child-care-centre-managers-in-qu%C3%A3-bec
#18
Fabien Gagnon, Patrick Poulin, Jean-Marc Leclerc, Jean-Claude Dessau, Aryan Abab, Pamela Arsenault, Fady El-Turaby, Guillaume Lachance-Paquette, Félix-Antoine Vézina
OBJECTIVES: To invite and support managers of child care centres to measure radon concentrations in their buildings. Their ability to carry out a measurement protocol and communication plan was also evaluated as well as the intention of parents and educators to test for radon at home. PARTICIPANTS: Managers, parents and educators of child care centres. SETTING: 36 child care centres located in two priority investigation areas in Québec. INTERVENTION: A kit containing radon detectors with installation and recovery instructions was shipped by mail in addition to factsheets intended for parents and educators...
October 20, 2016: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/27763320/standard-thoracic-endovascular-aortic-repair-compared-with-provisional-extension-to-induce-complete-attachment-in-aortic-dissection
#19
Kyle Arsenault, Darren Klass, Joel Price, Michael Janusz, Joel Gagnon, Jerry Chen, Jason Faulds
No abstract text is available yet for this article.
August 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27754772/determinants-of-improvement-in-left-ventricular-diastolic-function-following-a-1-year-lifestyle-modification-program-in-abdominally-obese-men-with-features-of-the-metabolic-syndrome
#20
Jacinthe Leclerc, Marie Arsenault, Jean-Pierre Després, Patrice Brassard, Valérie Gaudreault, Jean Bergeron, Natalie Alméras, Angelo Tremblay, Audrey Auclair, Marie-Kristelle Ross, Stéphanie Denault-Bissonnette, Paul Poirier
BACKGROUND: Abdominal obesity and presence of the metabolic syndrome (MetS) are associated with cardiac abnormalities. Among those, left ventricular diastolic dysfunction (LVDD) is the most frequently encountered in clinical practice. Few studies evaluated the reversibility of LVDD by an approach promoting lifestyle modifications in abdominally obese subjects with MetS. METHODS: We assessed the impact of a 1-year lifestyle modification program combining nutritional and physical activity counseling on LVDD and metabolic profile of abdominally obese men with MetS...
December 2016: Metabolic Syndrome and related Disorders
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