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https://www.readbyqxmd.com/read/27919352/impact-of-a-1-year-lifestyle-modification-program-on-plasma-lipoprotein-and-pcsk9-concentrations-in-patients-with-coronary-artery-disease
#1
Marjorie Boyer, Valérie Lévesque, Paul Poirier, André Marette, Patrick Mathieu, Jean-Pierre Després, Éric Larose, Benoit J Arsenault
BACKGROUND: Patients with coronary artery disease (CAD) are characterized by an impaired cardiometabolic risk profile including high levels of atherogenic apolipoprotein (apo) B-containing lipoprotein levels. Genetic studies have highlighted a critical role for proprotein convertase subtilisin/kexin type 9 (PCSK9) in lipoprotein metabolism and CAD risk. OBJECTIVE: To determine whether improving dietary quality and increasing physical activity levels improve parameters of the cardiometabolic risk profile such as plasma apoB and PCSK9 levels in patients with CAD...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27904236/influence-of-exercise-on-patients-with-guillain-barr%C3%A3-syndrome-a-systematic-review
#2
Nicholas Simatos Arsenault, Pierre-Olivier Vincent, Bai He Shen Yu, Robin Bastien, Aaron Sweeney
Purpose: To evaluate the effects of exercise interventions on improving physical outcomes in patients with Guillain-Barré syndrome (GBS). Methods: The PubMed database was searched for articles published up to and including February 2015. Randomized controlled trials (RCTs), case reports, and quasi-experimental and single-subject designs published in English-language, peer-reviewed journals that assessed the impact of physical exercise on patients with GBS were included; study quality was assessed using Sackett's rules of evidence...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27903326/characterizing-areas-of-potential-human-exposure-to-eastern-equine-encephalitis-virus-using-serological-and-clinical-data-from-horses
#3
J-P Rocheleau, J Arsenault, N H Ogden, L R Lindsay, M Drebot, P Michel
Eastern equine encephalitis (EEE) is a rare but severe emerging vector-borne disease affecting human and animal populations in the northeastern United States where it is endemic. Key knowledge gaps remain about the epidemiology of EEE virus (EEEV) in areas where its emergence has more recently been reported. In Eastern Canada, viral activity has been recorded in mosquitoes and horses throughout the 2000s but cases of EEEV in humans have not been reported so far. This study was designed to provide an assessment of possible EEEV human exposure by modelling environmental risk factors for EEEV in horses, identifying high-risk environments and mapping risk in the province of Quebec, Canada...
December 1, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27862827/comparison-of-radiation-exposure-during-transradial-diagnostic-coronary-angiography-with-single-or-multi-catheters-approach
#4
Guillaume Plourde, Eltigani Abdelaal, Jimmy MacHaalany, Goran Rimac, Yann Poirier, Jean Arsenault, Olivier Costerousse, Olivier F Bertrand
OBJECTIVE: To compare radiation exposure during transradial diagnostic coronary angiography (DCA) using standard single- or multi-catheters with different shapes. BACKGROUND: Transradial DCA can be performed using single- or multi-catheters to canulate left and right coronary ostia. To date, it remains unknown whether there are differences in radiation exposure between the two strategies. METHODS: From November 2012 to June 2014, 3,410 consecutive patients who underwent transradial DCA were recruited...
November 10, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27856457/carriers-of-the-pcsk9-proprotein-convertase-subtilisin-kexin-9-r46l-variant-are-characterized-by-an-antiatherogenic-lipoprotein-profile-assessed-by-nuclear-magnetic-resonance-spectroscopy
#5
Rutger Verbeek, Marjorie Boyer, S Matthijs Boekholdt, G Kees Hovingh, John J P Kastelein, Nicholas Wareham, Kay-Tee Khaw, Benoit J Arsenault
OBJECTIVE: Carriers of the PCSK9 (proprotein convertase subtilisin/kexin 9) R46L genetic variant (rs11591147) are characterized by low levels of low-density lipoprotein cholesterol and a decreased risk of cardiovascular disease. We studied the impact of the R46L variant on lipoprotein size and composition. APPROACH AND RESULTS: Lipoprotein size and composition were measured by nuclear magnetic resonance spectroscopy in 2373 participants of the EPIC (European Prospective Investigation into Cancer and Nutrition)-Norfolk study...
November 17, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27850762/1125-critical-care-observation-of-motor-activity-a-routine-bedside-exam-on-sicu-outcomes
#6
Sandra Muse, Colleen Arsenault, Tharusan Thevathasan, Annop Piriyapatsom, Karen Waak, Ulrich Schmidt, Matthias Eikermann
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27786253/synchronizing-stochastic-circadian-oscillators-in-single-cells-of-neurospora-crassa
#7
Zhaojie Deng, Sam Arsenault, Cristian Caranica, James Griffith, Taotao Zhu, Ahmad Al-Omari, Heinz-Bernd Schüttler, Jonathan Arnold, Leidong Mao
The synchronization of stochastic coupled oscillators is a central problem in physics and an emerging problem in biology, particularly in the context of circadian rhythms. Most measurements on the biological clock are made at the macroscopic level of millions of cells. Here measurements are made on the oscillators in single cells of the model fungal system, Neurospora crassa, with droplet microfluidics and the use of a fluorescent recorder hooked up to a promoter on a clock controlled gene-2 (ccg-2). The oscillators of individual cells are stochastic with a period near 21 hours (h), and using a stochastic clock network ensemble fitted by Markov Chain Monte Carlo implemented on general-purpose graphical processing units (or GPGPUs) we estimated that >94% of the variation in ccg-2 expression was stochastic (as opposed to experimental error)...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27770548/identification-of-small-molecule-phd2-zinc-finger-inhibitors-that-activate-hypoxia-inducible-factor
#8
Patrick R Arsenault, Daisheng Song, Marian Bergkamp, Andrew M Ravaschiere, Bradleigh E Navalsky, Paul M Lieberman, Frank S Lee
The prolyl hydroxylase domain (PHD) protein:hypoxia inducible factor (HIF) pathway is the main pathway by which changes in oxygen concentration are transduced to changes in gene expression. In mammals, there are three PHD paralogues, and PHD2 has emerged as a particularly critical one for regulating HIF target genes such as erythropoietin (EPO), which controls red cell mass and hematocrit. PHD2 is distinctive among the three PHDs in that it contains an N-terminal MYND-type zinc finger. We have proposed that this zinc finger binds a Pro-Xaa-Leu-Glu (PXLE) motif found in proteins of the HSP90 pathway to facilitate HIF-α hydroxylation...
October 22, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27763849/implementation-of-a-radon-measurement-protocol-and-its-communication-plan-by-child-care-centre-managers-in-qu%C3%A3-bec
#9
Fabien Gagnon, Patrick Poulin, Jean-Marc Leclerc, Jean-Claude Dessau, Aryan Abab, Pamela Arsenault, Fady El-Turaby, Guillaume Lachance-Paquette, Félix-Antoine Vézina
OBJECTIVES: To invite and support managers of child care centres to measure radon concentrations in their buildings. Their ability to carry out a measurement protocol and communication plan was also evaluated as well as the intention of parents and educators to test for radon at home. PARTICIPANTS: Managers, parents and educators of child care centres. SETTING: 36 child care centres located in two priority investigation areas in Québec. INTERVENTION: A kit containing radon detectors with installation and recovery instructions was shipped by mail in addition to factsheets intended for parents and educators...
October 20, 2016: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/27763320/standard-thoracic-endovascular-aortic-repair-compared-with-provisional-extension-to-induce-complete-attachment-in-aortic-dissection
#10
Kyle Arsenault, Darren Klass, Joel Price, Michael Janusz, Joel Gagnon, Jerry Chen, Jason Faulds
No abstract text is available yet for this article.
August 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27754772/determinants-of-improvement-in-left-ventricular-diastolic-function-following-a-1-year-lifestyle-modification-program-in-abdominally-obese-men-with-features-of-the-metabolic-syndrome
#11
Jacinthe Leclerc, Marie Arsenault, Jean-Pierre Després, Patrice Brassard, Valérie Gaudreault, Jean Bergeron, Natalie Alméras, Angelo Tremblay, Audrey Auclair, Marie-Kristelle Ross, Stéphanie Denault-Bissonnette, Paul Poirier
BACKGROUND: Abdominal obesity and presence of the metabolic syndrome (MetS) are associated with cardiac abnormalities. Among those, left ventricular diastolic dysfunction (LVDD) is the most frequently encountered in clinical practice. Few studies evaluated the reversibility of LVDD by an approach promoting lifestyle modifications in abdominally obese subjects with MetS. METHODS: We assessed the impact of a 1-year lifestyle modification program combining nutritional and physical activity counseling on LVDD and metabolic profile of abdominally obese men with MetS...
December 2016: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/27746971/reducing-exposure-to-cardiovascular-risk-factors-the-legacy-of-prevention
#12
COMMENT
Benoit J Arsenault, Rishi Puri
No abstract text is available yet for this article.
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27736966/exercise-lowers-plasma-angiopoietin-like-2-in-men-with-post-acute-coronary-syndrome
#13
Nathalie Thorin-Trescases, Doug Hayami, Carol Yu, Xiaoyan Luo, Albert Nguyen, Jean-François Larouche, Julie Lalongé, Christine Henri, André Arsenault, Mathieu Gayda, Martin Juneau, Jean Lambert, Eric Thorin, Anil Nigam
Pro-inflammatory angiopoietin-like 2 (angptl2) promotes endothelial dysfunction in mice and circulating angptl2 is higher in patients with cardiovascular diseases. We previously reported that a single bout of physical exercise was able to reduce angptl2 levels in coronary patients. We hypothesized that chronic exercise would reduce angptl2 in patients with post-acute coronary syndrome (ACS) and endothelial dysfunction. Post-ACS patients (n = 40, 10 women) were enrolled in a 3-month exercise-based prevention program...
2016: PloS One
https://www.readbyqxmd.com/read/27730635/energy-allocation-strategy-of-skipjack-tuna-katsuwonus-pelamis-during-their-reproductive-cycle
#14
M Grande, H Murua, I Zudaire, E J Arsenault-Pernet, F Pernet, N Bodin
The lipid composition of somatic and reproductive tissues was determined for female skipjack tuna Katsuwonus pelamis caught in the western Indian Ocean between latitude 10° N and 20° S and longitude 40° and 70° E. The highest total lipid (TL) contents were in the liver and gonads, with white muscle levels approximately three-fold lower. Three lipid classes dominated: triacylglycerols (TAG), sterol esters and wax esters (SE-WE) and phospholipids (PL). Collectively, these accounted for between 70 and 80% of TLs...
October 11, 2016: Journal of Fish Biology
https://www.readbyqxmd.com/read/27700086/microwave-spectra-structure-and-ring-puckering-vibration-of-octafluorocyclopentene
#15
Brittany E Long, Eric A Arsenault, Daniel A Obenchain, Yoon Jeong Choi, Esther J Ocola, Jaan Laane, Wallace C Pringle, Stephen Anthony Cooke
The rotational spectra of octafluorocyclopentene, C5F8, has been measured for the first time using pulsed jet Fourier transform microwave spectroscopy in a frequency range of 6 GHz to 16 GHz. As in the molecule cyclopentene, the carbon ring is non-planar and inversion through the plane results in an inversion pair of ground state vibrational energy levels with an inversion splitting of 18.4 MHz. This large amplitude motion leads to the vibration-rotation coupling of energy levels. The symmetric double minimum ring puckering potential function was calculated, resulting in a barrier of 222 cm-1...
October 4, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27695781/investigation-of-the-physiological-behavioral-and-biochemical-responses-of-cattle-to-restraint-stress
#16
Y Chen, J Stookey, R Arsenault, E Scruten, P Griebel, S Napper
Stresses imposed on livestock have significant impact on their health and productivity as well as public perceptions of animal welfare. Understanding stress responses in livestock may help refine management procedures and facilitate selection of stress-tolerant animals. In this study, behavioral (chute entry order, chute behavior, and exit velocity), physiological (serum cortisol), and biochemical (kinome) responses were evaluated in cattle ( = 20) subjected to three 5-min restraint periods with weekly intervals...
August 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27648687/rooted-in-risk-genetic-predisposition-for-low-density-lipoprotein-cholesterol-level-associates-with-diminished-low-density-lipoprotein-cholesterol-response-to-statin-treatment
#17
Roelof Aj Smit, Iris Postmus, Stella Trompet, Michael R Barnes, Helen Warren, Benoit J Arsenault, Daniel I Chasman, L Adrienne Cupples, Graham A Hitman, Ronald M Krauss, Xiaohui Li, Bruce M Psaty, Charles M Stein, Jerome I Rotter, J Wouter Jukema
AIMS: To utilize previously reported lead SNPs for low-density lipoprotein cholesterol (LDL-c) levels to find additional loci of importance to statin response, and examine whether genetic predisposition to LDL-c levels associates with differential statin response. METHODS: We investigated effects on statin response of 59 LDL-c SNPs, by combining summary level statistics from the Global Lipids Genetics and Genomic Investigation of Statin Therapy consortia. RESULTS: Lead SNPs for APOE, SORT1 and NPC1L1 were associated with a decreased LDL-c response to statin treatment, as was overall genetic predisposition for increased LDL-c levels as quantified with 59 SNPs, with a 5...
October 2016: Pharmacogenomics
https://www.readbyqxmd.com/read/27639727/arctic-micromonas-uses-protein-pools-and-non-photochemical-quenching-to-cope-with-temperature-restrictions-on-photosystem-ii-protein-turnover
#18
Guangyan Ni, Gabrielle Zimbalatti, Cole D Murphy, Audrey B Barnett, Christopher M Arsenault, Gang Li, Amanda M Cockshutt, Douglas A Campbell
Micromonas strains of small prasinophyte green algae are found throughout the world's oceans, exploiting widely different niches. We grew arctic and temperate strains of Micromonas and compared their susceptibilities to photoinactivation of Photosystem II, their counteracting Photosystem II repair capacities, their Photosystem II content, and their induction and relaxation of non-photochemical quenching. In the arctic strain Micromonas NCMA 2099, the cellular content of active Photosystem II represents only about 50 % of total Photosystem II protein, as a slow rate constant for clearance of PsbA protein limits instantaneous repair...
September 17, 2016: Photosynthesis Research
https://www.readbyqxmd.com/read/27630994/editorial-gut-health-the-new-paradigm-in-food-animal-production
#19
EDITORIAL
Michael H Kogut, Ryan J Arsenault
No abstract text is available yet for this article.
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27613902/effects-of-enactment-of-legislative-public-smoking-bans-on-voluntary-home-smoking-restrictions-a-review
#20
Eva Monson, Nicole Arsenault
INTRODUCTION: The positive effects of worldwide increases in enactment of legislative bans on smoking in public areas have been well documented. Relatively little is known about the effects of such bans on voluntary home smoking behavior. Meanwhile, private spaces, such as homes, have replaced public spaces as the primary milieu of secondhand smoke exposure. METHODS: A systematic search of peer-reviewed articles was conducted using multiple databases including Cochrane Library, Cinahl, Embase, Global Health, Health Star, Joanna Briggs, MEDLINE, PsycINFO, PAIS International, PubMed, and Web of Science...
July 12, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
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