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https://www.readbyqxmd.com/read/28522792/transgenic-autoinhibition-of-p21-activated-kinase-exacerbates-synaptic-impairments-and-fronto-dependent-behavioral-deficits-in-an-animal-model-of-alzheimer-s-disease
#1
Cyril Bories, Dany Arsenault, Myriam Lemire, Cyntia Tremblay, Yves De Koninck, Frédéric Calon
Defects in p21-activated kinase (PAK) lead to dendritic spine abnormalities and are sufficient to cause cognition impairment. The decrease in PAK in the brain of Alzheimer's disease (AD) patients is suspected to underlie synaptic and dendritic disturbances associated with its clinical expression, particularly with symptoms related to frontal cortex dysfunction. To investigate the role of PAK combined with Aβ and tau pathologies (3xTg-AD mice) in the frontal cortex, we generated a transgenic model of AD with a deficit in PAK activity (3xTg-AD-dnPAK mice)...
May 16, 2017: Aging
https://www.readbyqxmd.com/read/28472289/functional-similarity-of-medial-superior-parietal-areas-for-shift-selective-attention-signals-in-humans-and-monkeys
#2
Natalie Caspari, John T Arsenault, Rik Vandenberghe, Wim Vanduffel
We continually shift our attention between items in the visual environment. These attention shifts are usually based on task relevance (top-down) or the saliency of a sudden, unexpected stimulus (bottom-up), and are typically followed by goal-directed actions. It could be argued that any species that can covertly shift its focus of attention will rely on similar, evolutionarily conserved neural substrates for processing such shift-signals. To address this possibility, we performed comparative fMRI experiments in humans and monkeys, combining traditional, and novel, data-driven analytical approaches...
May 4, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28472283/oxldl-derived-lysophosphatidic-acid-promotes-the-progression-of-aortic-valve-stenosis-through-a-lpar1-rhoa-nf-%C3%AE%C2%BAb-pathway
#3
Mohamed Jalloul Nsaibia, Marie-Chloé Boulanger, Rihab Bouchareb, Ghada Mkannez, Khai Le Quang, Fayez Hadji, Deborah Argaud, Abdellaziz Dahou, Yohan Bossé, Marlys L Koschinsky, Philippe Pibarot, Benoit J Arsenault, André Marette, Patrick Mathieu
AIMS: Oxidatively modified lipoproteins may promote the development/progression of calcific aortic valve stenosis (CAVS). Oxidative transformation of low-density lipoprotein (OxLDL) generates lysophosphatidic acid (LPA), a lipid mediator that accumulates in mineralized aortic valves. LPA activates at least 6 different G protein-coupled receptors, which may play a role in the pathophysiology of CAVS. We hypothesized that LPA derived from OxLDL may promote a NF-κB signature that drives osteogenesis in the aortic valve...
May 4, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28453620/cavd-civilization-aortic-valve-disease
#4
Patrick Mathieu, Benoit J Arsenault
No abstract text is available yet for this article.
April 26, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28421074/immunometabolic-phenotype-alterations-associated-with-the-induction-of-disease-tolerance-and-persistent-asymptomatic-infection-of-salmonella-in-the-chicken-intestine
#5
REVIEW
Michael H Kogut, Ryan J Arsenault
The adaptation of Salmonella enterica to the eukaryotic host is a key process that enables the bacterium to survive in a hostile environment. Salmonella have evolved an intimate relationship with its host that extends to their cellular and molecular levels. Colonization, invasion, and replication of the bacteria in an appropriate host suggest that modification of host functions is central to pathogenesis. Intuitively, this subversion of the cell must be a complex process, since hosts are not inherently programmed to provide an environment conducive to pathogens...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28408054/radiation-therapy-quality-indicators-for-invasive-breast-cancer
#6
Lara Best, Catherine de Metz, Ivo A Olivotto, Isabelle Roy, Tim Whelan, Julie Arsenault, Michael Brundage
BACKGROUND AND PURPOSE: Radiation therapy (RT) for breast cancer has evolved considerably over the past two decades. A concise list of optimal care indexes is lacking. The purpose of this project was to generate a suite of quality of care indicators for breast cancer RT. MATERIALS AND METHODS: A modified Delphi approach was used including a comprehensive literature and guideline review (1995-2015), an initial review of potential quality indicators (QIs) by a steering committee, a survey of Canadian Radiation Oncologists, and a face-to-face consensus development meeting with breast cancer experts to develop a list of breast RT quality indicators...
May 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28406720/besoins-criants-gains-modestes%C3%A2-l-acc%C3%A3-s-%C3%A3-des-soins-de-sant%C3%A3-mentale-en-fran%C3%A3-ais-en-ontario-1968%C3%A2-1989
#7
Mathieu Arsenault, Marcel Martel
No abstract text is available yet for this article.
April 13, 2017: Canadian Bulletin of Medical History, Bulletin Canadien D'histoire de la Médecine
https://www.readbyqxmd.com/read/28399276/a-risk-model-for-the-lyme-disease-vector-ixodes-scapularis-acari-ixodidae-in-the-prairie-provinces-of-canada
#8
Vanessa Gabriele-Rivet, Jules K Koffi, Yann Pelcat, Julie Arsenault, Angela Cheng, L Robbin Lindsay, Timothy J Lysyk, Kateryn Rochon, Nicholas H Ogden
Lyme disease is emerging in Canada due to geographic range expansion of the tick vector Ixodes scapularis Say. Recent areas of emergence include parts of the southeastern Canadian Prairie region. We developed a map of potential risk areas for future I. scapularis establishment in the Canadian Prairie Provinces. Six I. scapularis risk algorithms were developed using different formulations of three indices for environmental suitability: temperature using annual cumulative degree-days > 0 °C (DD > 0 °C; obtained from Moderate Resolution Imaging Spectroradiometer satellite data as an index of conditions that allow I...
February 26, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28399168/global-trends-in-dietary-micronutrient-supplies-and-estimated-prevalence-of-inadequate-intakes
#9
Ty Beal, Eric Massiot, Joanne E Arsenault, Matthew R Smith, Robert J Hijmans
Understanding dietary patterns is vital to reducing the number of people experiencing hunger (about 795 million), micronutrient deficiencies (2 billion), and overweight or obesity (2.1 billion). We characterize global trends in dietary quality by estimating micronutrient density of the food supply, prevalence of inadequate intake of 14 micronutrients, and average prevalence of inadequate intake of these micronutrients for all countries between 1961 and 2011. Over this 50-year period, the estimated prevalence of inadequate intakes of micronutrients has declined in all regions due to increased total production of food and/or micronutrient density...
2017: PloS One
https://www.readbyqxmd.com/read/28391649/prevalence-and-mode-of-inheritance-of-the-dal-blood-group-in-dogs-in-north-america
#10
S Goulet, U Giger, J Arsenault, A Abrams-Ogg, C C Euler, M-C Blais
BACKGROUND: The Dal blood group system was identified a decade ago by the accidental sensitization of a Dal- Dalmatian with a Dal+ blood transfusion. Similar Dal-related blood incompatibilities have been suspected in other Dalmatians, Doberman Pinschers, and other breeds. OBJECTIVES: To determine the prevalence and mode of inheritance of the Dal antigen expression in dogs. ANIMALS: A total of 1130 dogs including 128 Dalmatians, 432 Doberman Pinschers, 21 Shih Tzus, and 549 dogs of other breeds including 228 blood donors were recruited from North America between 2008 and 2015...
May 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28389667/female-rats-with-severe-left-ventricle-volume-overload-exhibit-more-cardiac-hypertrophy-but-fewer-myocardial-transcriptional-changes-than-males
#11
Catherine Beaumont, Élisabeth Walsh-Wilkinson, Marie-Claude Drolet, Élise Roussel, Marie Arsenault, Jacques Couet
Aortic valve regurgitation (AR) imposes a volume overload (VO) to the left ventricle (LV). Male rats with a pathological heart overload usually progress more quickly towards heart failure than females. We examined whether a sexual dimorphism exists in the myocardial transcriptional adaptations to AR. Adult Wistar male and female rats either underwent a sham operation or were induced with AR and then followed for 26 weeks. Female AR rats gained relatively more LV mass than males (75 vs. 42%). They had a similar increase in LV chamber dimensions compared to males but more wall thickening...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28388501/the-heights-of-french-canadian-convicts-1780s-1820s
#12
Alex Arsenault Morin, Vincent Geloso, Vadim Kufenko
This paper uses a novel dataset of heights collected from the records of the Quebec City prison between 1813 and 1847 to survey the French-Canadian population of Quebec-which was then known either as Lower Canada or Canada East. Using a birth-cohort approach with 10year birth cohorts from the 1780s to the 1820s, we find that French-Canadian prisoners grew shorter over the period. Through the whole sample period, they were short compared to Americans. However, French-Canadians were taller either than their cousins in France or the inhabitants of Latin America (except Argentinians)...
March 16, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/28365251/country-level-predictors-of-vaccination-coverage-and-inequalities-in-gavi-supported-countries
#13
Catherine Arsenault, Mira Johri, Arijit Nandi, José M Mendoza Rodríguez, Peter M Hansen, Sam Harper
BACKGROUND: Important inequalities in childhood vaccination coverage persist between countries and population groups. Understanding why some countries achieve higher and more equitable levels of coverage is crucial to redress these inequalities. In this study, we explored the country-level determinants of (1) coverage of the third dose of diphtheria-tetanus-pertussis- (DTP3) containing vaccine and (2) within-country inequalities in DTP3 coverage in 45 countries supported by Gavi, the Vaccine Alliance...
March 29, 2017: Vaccine
https://www.readbyqxmd.com/read/28353509/innovative-urgent-care-for-the-palliative-patient-at-home
#14
Carmel L Montgomery, Charlotte Pooler, Julia E Arsenault, Colleen Berean, Robert Sharman, Cheryl L Cameron, Ingrid de Kock
Palliative and end-of-life patients in their homes are at risk of developing symptom crises requiring urgent care. The usual care for these patients involves transport to an Emergency Department (ED) despite the preference of most palliative patients to stay home. The objective of this initiative was to develop an innovative strategy to provide collaborative care in the home to alleviate symptoms and avoid transport. A partnership was created among Emergency Medical Services and Community Care staff, physicians, and leaders to enable patients to stay at home with existing resources during symptom crisis...
April 2017: Home Healthcare Now
https://www.readbyqxmd.com/read/28319871/autoantibodies-and-immune-complexes-to-oxidation-specific-epitopes-and-progression-of-aortic-stenosis-results-from-the-astronomer-trial
#15
Romain Capoulade, Kwan L Chan, Patrick Mathieu, Yohan Bossé, Jean G Dumesnil, James W Tam, Koon K Teo, Xiaohong Yang, Joseph L Witztum, Benoit J Arsenault, Jean-Pierre Després, Philippe Pibarot, Sotirios Tsimikas
BACKGROUND AND AIMS: Elevated levels of lipoprotein(a) [Lp(a)] and oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) predict the progression of pre-existing mild-to-moderate calcific aortic valve stenosis (CAVS). Whether indirect markers of oxidation-specific epitopes (OSE) are also predictive is not known. The association between IgG and IgM autoantibodies and malondialdehyde-modified low density lipoprotein (MDA-LDL) and IgG and IgM apolipoprotein B immune complexes (apoB-IC), and the hemodynamic progression rate of CAVS was determined in the ASTRONOMER (Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin, NCT00800800) trial...
May 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28290255/feeding-by-leucopis-argenticollis-and-leucopis-piniperda-diptera-chamaemyiidae-from-the-western-usa-on-adelges-tsugae-hemiptera-adelgidae-in-the-eastern-usa
#16
K Motley, N P Havill, A L Arsenault-Benoit, A E Mayfield, D S Ott, D Ross, M C Whitmore, K F Wallin
Leucopis argenticollis (Zetterstedt) and Leucopis piniperda (Malloch) are known to feed on the lineage of Adelges tsugae Annand that is native to western North America, but it is not known if they will survive on the lineage that was introduced from Japan to the eastern USA. In 2014, western Leucopis spp. larvae were brought to the laboratory and placed on A. tsugae collected in either Washington (North American A. tsugae lineage) or Connecticut (Japanese lineage). There were no significant differences in survival or developmental times between flies reared on the two different adelgid lineages...
March 14, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28276874/corrections-to-once-daily-controlled-release-pregabalin-in-the-treatment-of-patients-with-fibromyalgia-a-phase-iii-double-blind-randomized-withdrawal-placebo-controlled-study
#17
Lesley M Arnold, Pierre Arsenault, Cynthia Huffman, Jeffrey Patrick, Michael Messig, Marci Chew, Luis Sanin, Joseph Scavone, Lynne Pauer, Andrew Clair
No abstract text is available yet for this article.
April 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28250513/an-equity-dashboard-to-monitor-vaccination-coverage
#18
Catherine Arsenault, Sam Harper, Arijit Nandi, José M Mendoza Rodríguez, Peter M Hansen, Mira Johri
Equity monitoring is a priority for Gavi, the Vaccine Alliance, and for those implementing The2030 agenda for sustainable development. For its new phase of operations, Gavi reassessed its approach to monitoring equity in vaccination coverage. To help inform this effort, we made a systematic analysis of inequalities in vaccination coverage across 45 Gavi-supported countries and compared results from different measurement approaches. Based on our findings, we formulated recommendations for Gavi's equity monitoring approach...
February 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28244184/exploring-nurse-leader-fatigue-a-mixed-methods-study
#19
Linsey M Steege, Barbara J Pinekenstein, Élise Arsenault Knudsen, Jessica G Rainbow
AIM: To describe hospital nurse leaders' experiences of fatigue. BACKGROUND: Fatigue is a critical challenge in nursing. Existing literature focuses on staff nurse fatigue, yet nurse leaders are exposed to high demands that may contribute to fatigue and associated risks to patient, nurse and organisational outcomes. METHODS: A mixed method approach comprising semi-structured interviews and the Occupational Fatigue Exhaustion Recovery scale with 21 nurse administrators (10 nurse managers and 11 nurse executives) from hospitals in a Midwestern state...
May 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/28202900/cardiovascular-disease-prevention-lifestyle-attenuation-of-genetic-risk
#20
Benoit J Arsenault, Jean-Pierre Després
No abstract text is available yet for this article.
April 2017: Nature Reviews. Cardiology
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