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https://www.readbyqxmd.com/read/29659963/saturated-fats-from-butter-but-not-from-cheese-increase-hdl-mediated-cholesterol-efflux-capacity-from-j774-macrophages-in-men-and-women-with-abdominal-obesity
#1
Didier Brassard, Benoît J Arsenault, Marjorie Boyer, Daniela Bernic, Maude Tessier-Grenier, Denis Talbot, Angelo Tremblay, Emile Levy, Bela Asztalos, Peter J H Jones, Patrick Couture, Benoît Lamarche
Background: Recent evidence suggests that the association between dietary saturated fatty acids (SFAs) and coronary artery disease risk varies according to food sources. How SFAs from butter and cheese influence HDL-mediated cholesterol efflux capacity (CEC), a key process in reverse cholesterol transport, is currently unknown. Objective: In a predefined secondary analysis of a previously published trial, we have examined how diets rich in SFAs from either cheese or butter influence HDL-mediated CEC, compared with diets rich in either monounsaturated fatty acids (MUFAs) or polyunsaturated fatty acids (PUFAs)...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29596218/dietary-supplementation-with-medium-chain-triglycerides-reduces-candida-gastrointestinal-colonization-in-preterm-infants
#2
Amanda B Arsenault, Kearney T W Gunsalus, Sonia S Laforce-Nesbitt, Lynn Przystac, Erik J DeAngelis, Michaela E Hurley, Ethan S Vorel, Richard Tucker, Nirupa R Matthan, Alice H Lichtenstein, Carol A Kumamoto, Joseph M Bliss
BACKGROUND: Candida is an important cause of infections in premature infants. Gastrointestinal colonization with Candida is a common site of entry for disseminated disease. The objective of this study was to determine whether a dietary supplement of medium-chain triglycerides (MCTs) reduces Candida colonization in preterm infants. METHODS: Preterm infants with Candida colonization (n=12) receiving enteral feedings of either infant formula (n=5) or breastmilk (n=7) were randomized to MCT supplementation (n=8) or no supplementation (n=4)...
March 24, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29589299/dissecting-oncogenic-rtk-pathways-in-colorectal-cancer-initiation-and-progression
#3
Stephen McManus, Walid Chababi, Dominique Arsenault, Claire M Dubois, Caroline Saucier
Colorectal cancer (CRC) is a progressive disorder associated with an accumulation of multiple heterogeneous genetic alterations in intestinal epithelial cells (IEC). However, when these cells undergo neoplastic transformation and become cancerous and metastatic, they invariably acquire hallmarks conferring them the ability to hyperproliferate, escape growth-inhibitory and death-inducing cues, and promote angiogenesis as well as epithelial-to-mesenchymal transformation (EMT), fostering their invasive dissemination from primary tumor into distant tissues...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29573098/rosiglitazone-lowers-resting-and-blood-pressure-response-to-exercise-in-men-with-type-2-diabetes-a-1-year-randomized-study
#4
Marie-Eve Piché, Anne-Sophie Laberge, Patrice Brassard, Benoit J Arsenault, Olivier F Bertrand, Jean-Pierre Després, Olivier Costerousse, Paul Poirier
BACKGROUND: Individuals with type 2 diabetes (T2D) are insulin resistant and have a lower exercise capacity than individuals without T2D. AIMS: We examined the effect of 1 year treatment with the insulin sensitizer peroxisome proliferator-activated receptor (PPAR)-γ agonist rosiglitazone on exercise capacity and blood pressure (BP) response to exercise in men with coronary artery disease (CAD) and T2D. MATERIALS AND METHODS: One hundred and sixteen men (age: 64±7 yrs; body mass index: 30...
March 23, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29555093/neuroinflammation-related-encephalopathy-in-an-infant-born-preterm-following-exposure-to-maternal-diabetic-ketoacidosis
#5
David E Mandelbaum, Amanda Arsenault, Barbara S Stonestreet, Stefan Kostadinov, Suzanne M de la Monte
A pregnant woman with new-onset type 1 diabetes and ketoacidosis delivered an infant at 28 weeks of gestation who died with multiple organ failure and severe cerebral vasculopathy with extensive hemorrhage, diffuse microgliosis, and edema. This illustrates that antenatal metabolic and inflammatory stressors may be associated with neonatal encephalopathy and cerebral hemorrhage.
March 16, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29544176/environmental-controls-of-c-n-and-p-biogeochemistry-in-peatland-pools
#6
Julien Arsenault, Julie Talbot, Tim R Moore
Pools are common in northern peatlands but studies have seldom focused on their nutrient biogeochemistry, especially in relation to their morphological characteristics and through seasons. We determined the environmental characteristics controlling carbon (C), nitrogen (N) and phosphorus (P) biogeochemistry in pools and assessed their evolution over the course of the 2016 growing season in a subboreal ombrotrophic peatland of eastern Canada. We showed that water chemistry variations in 62 pools were significantly explained by depth (81...
March 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29496912/extended-linkers-improve-the-detection-of-protein-protein-interactions-ppis-by-dihydrofolate-reductase-protein-fragment-complementation-assay-dhfr-pca-in-living-cells
#7
Andrée-Ève Chrétien, Isabelle Gagnon-Arsenault, Alexandre K Dubé, Xavier Barbeau, Philippe C Després, Claudine Lamothe, Anne-Marie Dion-Côté, Patrick Lagüe, Christian R Landry
No abstract text is available yet for this article.
March 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29483075/ph-controls-spermatozoa-motility-in-the-pacific-oyster-crassostrea-gigas
#8
Myrina Boulais, Marc Suquet, Eve Julie Arsenault-Pernet, Florent Malo, Isabelle Queau, Patricia Pignet, Dominique Ratiskol, Jacqueline Le Grand, Matthias Huber, Jacky Cosson
Investigating the roles of chemical factors stimulating and inhibiting sperm motility is required to understand the mechanisms of spermatozoa movement. In this study, we described the composition of the seminal fluid (osmotic pressure, pH, and ions) and investigated the roles of these factors and salinity in initiating spermatozoa movement in the Pacific oyster. The acidic pH of the gonad (5.82 ± 0.22) maintained sperm in the quiescent stage and initiation of flagellar movement was triggered by a sudden increase of spermatozoa external pH (pHe) when released in seawater (SW)...
February 26, 2018: Biology Open
https://www.readbyqxmd.com/read/29440006/apob-apoa-i-ratio-is-associated-with-faster-hemodynamic-progression-of-aortic-stenosis-results-from-the-progressa-metabolic-determinants-of-the-progression-of-aortic-stenosis-study
#9
Lionel Tastet, Romain Capoulade, Mylène Shen, Marie-Annick Clavel, Nancy Côté, Patrick Mathieu, Marie Arsenault, Élisabeth Bédard, Alexe Tremblay, Marilie Samson, Yohan Bossé, Jean G Dumesnil, Benoit J Arsenault, Jonathan Beaudoin, Mathieu Bernier, Jean-Pierre Després, Philippe Pibarot
BACKGROUND: Previous studies reported that middle-aged patients with atherogenic lipoprotein-lipid profile exhibit faster progression of aortic valve stenosis (AS). The ratio of apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) reflects the balance between atherogenic and anti-atherogenic lipoproteins. The aim of this study was to examine the association between apoB/apoA-I ratio and AS hemodynamic progression and to determine whether this association varies according to age. METHODS AND RESULTS: A total of 159 patients (66±13 years, 73% men) with AS were prospectively recruited in the PROGRESSA (Metabolic Determinants of the Progression of Aortic Stenosis) study...
February 10, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29391386/extended-linkers-improve-the-detection-of-protein-protein-interactions-ppis-by-dihydrofolate-reductase-protein-fragment-complementation-assay-dhfr-pca-in-living-cells
#10
Andrée-Ève Chrétien, Isabelle Gagnon-Arsenault, Alexandre K Dubé, Xavier Barbeau, Philippe C Després, Claudine Lamothe, Anne-Marie Dion-Côté, Patrick Lagüe, Christian R Landry
Understanding the function of cellular systems requires describing how proteins assemble with each other into transient and stable complexes and to determine their spatial relationships. Among the tools available to perform these analyses on a large scale is Protein-fragment Complementation Assay based on the dihydrofolate reductase (DHFR PCA). Here we test how longer linkers between the fusion proteins and the reporter fragments affect the performance of this assay. We investigate the architecture of the RNA polymerases, the proteasome and the conserved oligomeric Golgi (COG) complexes in living cells and performed large-scale screens with these extended linkers...
February 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29373241/french-translation-and-cross-cultural-adaptation-of-the-michigan-hand-outcomes-questionnaire-and-the-brief-michigan-hand-outcomes-questionnaire
#11
J I Efanov, J J Shine, R Darwich, C Besner Morin, J Arsenault, P G Harris, A M Danino, A Izadpanah
Patient-Reported Outcome Measures (PROMs) are important clinical devices for evaluating injuries and surgeries of the hand. However, some of the most widely used questionnaires, such as the MHQ and bMHQ, are currently unavailable in French, which prevents them from being used in the French Canadian province of Quebec as well as in other French-speaking nations. We therefore intend to develop valid and culturally adapted French translations of the afore-mentioned questionnaires. Two independent bilingual translators converted all English questionnaires to French...
January 17, 2018: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29336671/the-indirect-effect-of-ethnic-identity-on-marijuana-use-through-school-engagement-an-african-american-high-school-sample
#12
Chelsea E Arsenault, Sycarah Fisher, Danelle Stevens-Watkins, Jessica Barnes-Najor
BACKGROUND: African American marijuana use is associated with many negative social, emotional, and health-related consequences. Of significance, over recent years this population has shown an increase in use. In the literature, ethnic identity and school engagement are prominent protective factors against substance use. OBJECTIVE: This study will examine how these protective factors are related, specifically whether ethnic identity mitigates risk through school engagement to reduce marijuana use...
January 16, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29300915/in-vivo-identification-of-thick-thin-and-pale-stripes-of-macaque-area-v2-using-submillimeter-resolution-f-mri-at-3-t
#13
Xiaolian Li, Qi Zhu, Thomas Janssens, John T Arsenault, Wim Vanduffel
Primate area V2 contains a repetitive pattern of thick, thin and pale cytochrome oxidase stripes that are characterized by largely discrete in- and output channels, as well as differences in function, and myelo- and cytoarchitecture. Stripes have been identified mainly using microscope-based imaging of tiny portions of superficially located V2, or by postmortem methods, hence, the quest for (quasi) noninvasive tools to study these mesoscale functional units. Only recently, stripe-like V2 patterns have been demonstrated in humans with high-field (functional) magnetic resonance imaging (f)MRI, but in both such studies only 2 stripe compartments could be identified...
December 28, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29249317/chicken-macrophages-infected-with-salmonella-s-enteritidis-or-s-heidelberg-produce-differential-responses-in-immune-and-metabolic-signaling-pathways
#14
Haiqi He, Ryan J Arsenault, Kenneth J Genovese, Casey Johnson, Michael H Kogut
Protein kinases act in coordination with phosphatases to control protein phosphorylation and regulate signaling pathways and cellular processes involved in nearly every functions of cell life. Salmonella are known to manipulate the host kinase network to gain entrance and survive inside host cells. The effect of Salmonella infection on the host kinase network has been studied in mammalian cells, but information is largely lacking in chicken immune cells. Our previous study indicated that chicken macrophage cells respond differentially to different Salmonella strains...
January 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29228930/gene-expression-analysis-in-asthma-using-a-targeted-multiplex-array
#15
Christopher D Pascoe, Ma'en Obeidat, Bryna A Arsenault, Yunlong Nie, Stephanie Warner, Dorota Stefanowicz, Samuel J Wadsworth, Jeremy A Hirota, S Jasemine Yang, Delbert R Dorscheid, Chris Carlsten, Tillie L Hackett, Chun Y Seow, Peter D Paré
BACKGROUND: Gene expression changes in the structural cells of the airways are thought to play a role in the development of asthma and airway hyperresponsiveness. This includes changes to smooth muscle contractile machinery and epithelial barrier integrity genes. We used a targeted gene expression arrays to identify changes in the expression and co-expression of genes important in asthma pathology. METHODS: RNA was isolated from the airways of donor lungs from 12 patients with asthma (8 fatal) and 12 non-asthmatics controls and analyzed using a multiplexed, hypothesis-directed platform to detect differences in gene expression...
December 11, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29203496/extended-linkers-improve-the-detection-of-protein-protein-interactions-ppis-by-dihydrofolate-reductase-protein-fragment-complementation-assay-dhfr-pca-in-living-cells
#16
Andrée-Ève Chrétien, Isabelle Gagnon-Arsenault, Alexandre K Dubé, Xavier Barbeau, Philippe C Després, Claudine Lamothe, Anne-Marie Dion-Côté, Patrick Lagüe, Christian R Landry
Understanding the function of cellular systems requires describing how proteins assemble with each other into transient and stable complexes and to determine their spatial relationships. Among the tools available to perform these analyses on a large scale is Protein-fragment Complementation Assay based on the dihydrofolate reductase (DHFR PCA). Here we test how longer linkers between the fusion proteins and the reporter fragments affect the performance of this assay. We investigate the architecture of the RNA polymerases, the proteasome and the conserved oligomeric Golgi (COG) complexes in living cells and performed large-scale screens with these extended linkers...
February 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29157366/culling-from-the-actors-perspectives-decision-making-criteria-for-culling-in-qu%C3%A3-bec-dairy-herds-enrolled-in-a-veterinary-preventive-medicine-program
#17
Denis Haine, Roger Cue, Asheber Sewalem, Kevin Wade, René Lacroix, Daniel Lefebvre, Jonathan Rushton, Julie Arsenault, Émile Bouchard, Jocelyn Dubuc
The series of events leading to the decision to cull a cow is complex, involving both individual-level and herd-level factors. While the decision is guided by financial returns, it is also influenced by social and psychological factors. Research studies on the motivational and behavioural aspects of farmers' decision utility are sparse, and nonexistent regarding culling expectations and its decision process. Our goal was to identify shared criteria on culling decisions held by dairy producers and farm advisers, with the help of the Q-methodology...
December 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29138462/the-antibacterial-and-anti-inflammatory-activity-of-chicken-cathelicidin-2-combined-with-exogenous-surfactant-for-the-treatment-of-cystic-fibrosis-associated-pathogens
#18
Brandon J H Banaschewski, Brandon Baer, Christina Arsenault, Teah Jazey, Edwin J A Veldhuizen, Johan Delport, Tracey Gooyers, James F Lewis, Henk P Haagsman, Ruud A W Veldhuizen, Cory Yamashita
Cystic fibrosis (CF) is characterized by recurrent airway infections with antibiotic-resistant bacteria and chronic inflammation. Chicken cathelicin-2 (CATH-2) has been shown to exhibit antimicrobial activity against antibiotic-resistant bacteria and to reduce inflammation. In addition, exogenous pulmonary surfactant has been suggested to enhance pulmonary drug delivery. It was hypothesized that CATH-2 when combined with an exogenous surfactant delivery vehicle, bovine lipid extract surfactant (BLES), would exhibit antimicrobial activity against CF-derived bacteria and downregulate inflammation...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29110186/patient-safety-ward-round-checklist-via-an-electronic-app-implications-for-harm-prevention
#19
C Keller, S Arsenault, M Lamothe, S R Bostan, R O'Donnell, J Harbison, C P Doherty
INTRODUCTION: Patient safety is a value at the core of modern healthcare. Though awareness in the medical community is growing, implementing systematic approaches similar to those used in other high reliability industries is proving difficult. The aim of this research was twofold, to establish a baseline for patient safety practices on routine ward rounds and to test the feasibility of implementing an electronic patient safety checklist application. METHODS: Two research teams were formed; one auditing a medical team to establish a procedural baseline of "usual care" practice and an intervention team concurrently was enforcing the implementation of the checklist...
November 6, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29103916/effect-of-atorvastatin-cholesterol-ester-transfer-protein-inhibition-and-diabetes-mellitus-on-circulating-proprotein-subtilisin-kexin-type-9-and-lipoprotein-a-levels-in-patients-at-high-cardiovascular-risk
#20
Benoit J Arsenault, Francine Petrides, Fatiha Tabet, Weihang Bao, G Kees Hovingh, S Matthijs Boekholdt, Stéphane Ramin-Mangata, Olivier Meilhac, David DeMicco, Kerry-Anne Rye, David D Waters, John J P Kastelein, Philip Barter, Gilles Lambert
BACKGROUND: Proprotein subtilisin kexin type 9 (PCSK9) and lipoprotein (a) [Lp(a)] levels are causative risk factors for coronary heart disease. OBJECTIVES: The objective of the study was to determine the impact of lipid-lowering treatments on circulating PCSK9 and Lp(a). METHODS: We measured PCSK9 and Lp(a) levels in plasma samples from Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events trial patients with coronary heart disease and/or type II diabetes (T2D) mellitus...
October 12, 2017: Journal of Clinical Lipidology
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