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https://www.readbyqxmd.com/read/28973091/association-of-paravalvular-regurgitation-with-1-year-outcomes-after-transcatheter-aortic-valve-replacement-with-the-sapien-3-valve
#1
Philippe Pibarot, Rebecca T Hahn, Neil J Weissman, Marie Arsenault, Jonathan Beaudoin, Mathieu Bernier, Abdellaziz Dahou, Omar K Khalique, Federico M Asch, Oumhani Toubal, Jonathon Leipsic, Philipp Blanke, Feifan Zhang, Rupa Parvataneni, Maria Alu, Howard Herrmann, Raj Makkar, Michael Mack, Richard Smalling, Martin Leon, Vinod H Thourani, Susheel Kodali
Importance: Moderate/severe and even mild paravalvular regurgitation (PVR) are associated with increased mortality following transcatheter aortic valve replacement (TAVR) with first and second generations of transcatheter valves. Objective: To examine the incidence, evolution, and effect on 1-year outcomes of PVR following TAVR with a third-generation balloon-expandable transcatheter heart valve. Design, Setting, and Participants: Prespecified analysis of PVR in the Placement of Aortic Transcatheter Valves (PARTNER) II SAPIEN 3 trial, conducted between October 1, 2013, and September 3, 2014...
September 27, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28956525/emerging-arboviruses-in-quebec-canada-assessing-public-health-risk-by-serology-in-humans-horses-and-pet-dogs
#2
J P Rocheleau, P Michel, L R Lindsay, M Drebot, A Dibernardo, N H Ogden, A Fortin, J Arsenault
Periodic outbreaks of West Nile virus (WNV), Eastern equine encephalitis virus (EEEV) and to a lesser extent, California serogroup viruses (CSGV), have been reported in parts of Canada in the last decade. This study was designed to provide a broad assessment of arboviral activity in Quebec, Canada, by conducting serological surveys for these arboviruses in 196 horses, 1442 dogs and 485 humans. Sera were screened by a competitive enzyme linked immunosorbent assay and positive samples confirmed by plaque reduction neutralisation tests...
September 28, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28938793/effects-of-protein-or-amino-acid-supplementation-on-the-physical-growth-of-young-children-in-low-income-countries
#3
Joanne E Arsenault, Kenneth H Brown
Child growth stunting is common in low-income countries, possibly due to insufficient protein intakes. Most previous studies have concluded that children's protein intakes are adequate in relation to estimated requirements, but these studies did not consider issues of protein digestibility and effects of infection on dietary protein utilization. Using an alternative approach to assess the possible role of protein inadequacy in children's growth restriction, the results of 18 intervention trials in which supplementary protein or amino acids were provided to children ages 6-35 months and growth outcomes were reviewed...
September 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28938493/acute-and-chronic-impact-of-bariatric-surgery-on-plasma-ldl-cholesterol-and-pcsk9-levels-in-patients-with-severe-obesity
#4
Marjorie Boyer, Marie-Eve Piché, Audrey Auclair, Thomas Grenier-Larouche, Laurent Biertho, Simon Marceau, Frédéric-Simon Hould, Simon Biron, Stéfane Lebel, Odette Lescelleur, François Julien, Julie Martin, André Tchernof, André C Carpentier, Paul Poirier, Benoit J Arsenault
Context: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of low-density lipoprotein cholesterol (LDL-C) concentrations. In patients with severe obesity, biliopancreatic diversion with duodenal switch (BPD-DS) surgery induces substantial weight loss and favourably influence lipoprotein metabolism. The impact of BPD-DS surgery on PCSK9 levels is unknown. Objectives: To determine the acute and chronic impact of BPD-DS surgery on PCSK9 levels and whether the acute impact of BPD-DS could be explained by BPD-DS surgery-associated caloric restriction (CR)...
August 24, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28902478/development-reliability-and-use-of-a-food-environment-assessment-tool-in-supermarkets-of-four-neighbourhoods-in-montr%C3%A3-al-canada
#5
Élise Jalbert-Arsenault, Éric Robitaille, Marie-Claude Paquette
INTRODUCTION: The food environment is a promising arena in which to influence people's dietary habits. This study aimed to develop a comprehensive food environment assessment tool for businesses and characterize the food environment of a low-tomedium income area of Montréal, Canada. METHODS: We developed a tool, Mesure de l'environnement alimentaire du consommateur dans les supermarchés (MEAC-S), and tested it for reliability. We used the MEAC-S to assess the consumer food environment of 17 supermarkets in four neighbourhoods of Montréal...
September 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28889112/interplay-between-cigarette-smoking-and%C3%A2-pulmonary-reverse-lipid-transport
#6
Éric Jubinville, Maude Talbot, Jean-Christophe Bérubé, Mélanie Hamel-Auger, Michaël Maranda-Robitaille, Marie-Josée Beaulieu, Sophie Aubin, Marie-Ève Paré, David G Kallend, Benoit Arsenault, Yohan Bossé, Mathieu C Morissette
Reverse lipid transport is critical to maintain homeostasis. Smoking causes lipid accumulation in macrophages, therefore suggesting suboptimal reverse lipid transport mechanisms. In this study, we investigated the interplay between smoking and reverse lipid transport and the consequences on smoking-induced lung and peripheral alterations.To investigate the relationship between smoking and reverse lipid transport, we used a clinical lung gene expression dataset and a mouse model of cigarette smoke exposure. We also used ApoA-1(-/-) mice, with reduced reverse lipid transport capacity, and a recombinant ApoA-1 Milano/phospholipid complex (MDCO-216) to boost reverse lipid transport...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28885538/clinical-relevance-of-18f-fdg-pet-ct-lower-limb-imaging-in-patients-with-malignant-cutaneous-melanoma
#7
Nicolas Plouznikoff, Frédéric Arsenault
OBJECTIVE: The aim of this study was to assess the clinical relevance of imaging the lower limbs when using 2-(F)-fluoro-2-deoxy-D-glucose (F-FDG) positron emission tomography with computed tomography (PET/CT) for malignant cutaneous melanoma in patients without previously known or suspected primary or metastatic melanoma lesions in the lower limbs. PATIENTS AND METHODS: We retrospectively assessed 880 consecutive F-FDG PET/CT scans performed for adult patients in a context of suspected melanoma spanning a period of 5 years...
September 6, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28858957/addressing-occupational-fatigue-in-nurses-current-state-of-fatigue-risk-management-in-hospitals-part-2
#8
Linsey M Steege, Barbara J Pinekenstein, Jessica G Rainbow, Élise Arsenault Knudsen
OBJECTIVE: The aim of this article is to describe the current state of fatigue risk management systems (FRMSs) to address nurse fatigue in hospitals. BACKGROUND: Little is known about the current state of FRMS implementation and adoption of national recommendations in nursing work systems. METHODS: This study used a sequential exploratory mixed-methods design including a survey of nurse leaders from across the United States. RESULTS: Adoption of evidence-based policies to address fatigue is both limited and variable depending on the policy...
October 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28854636/variation-in-dna-methylation-is-not-consistently-reflected-by-sociality-in-hymenoptera
#9
Karl M Glastad, Samuel V Arsenault, Kim L Vertacnik, Scott M Geib, Sasha Kay, Bryan N Danforth, Sandra M Rehan, Catherine R Linnen, Sarah D Kocher, Brendan G Hunt
Changes in gene regulation that underlie phenotypic evolution can be encoded directly in the DNA sequence or mediated by chromatin modifications such as DNA methylation. It has been hypothesized that the evolution of eusocial division of labor is associated with enhanced gene regulatory potential, which may include expansions in DNA methylation in the genomes of Hymenoptera (bees, ants, wasps, and sawflies). Recently, this hypothesis garnered support from analyses of a commonly used metric to estimate DNA methylation in silico, CpG content...
June 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28835296/characterizing-environmental-risk-factors-for-west-nile-virus-in-quebec-canada-using-clinical-data-in-humans-and-serology-in-pet-dogs
#10
J P Rocheleau, P Michel, L R Lindsay, M Drebot, A Dibernardo, N H Ogden, A Fortin, J Arsenault
The identification of specific environments sustaining emerging arbovirus amplification and transmission to humans is a key component of public health intervention planning. This study aimed at identifying environmental factors associated with West Nile virus (WNV) infections in southern Quebec, Canada, by modelling and jointly interpreting aggregated clinical data in humans and serological data in pet dogs. Environmental risk factors were estimated in humans by negative binomial regression based on a dataset of 191 human WNV clinical cases reported in the study area between 2011 and 2014...
October 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28829397/precision-nutrition-a-review-of-personalized-nutritional-approaches-for-the-prevention-and-management-of-metabolic-syndrome
#11
REVIEW
Juan de Toro-Martín, Benoit J Arsenault, Jean-Pierre Després, Marie-Claude Vohl
The translation of the growing increase of findings emerging from basic nutritional science into meaningful and clinically relevant dietary advices represents nowadays one of the main challenges of clinical nutrition. From nutrigenomics to deep phenotyping, many factors need to be taken into account in designing personalized and unbiased nutritional solutions for individuals or population sub-groups. Likewise, a concerted effort among basic, clinical scientists and health professionals will be needed to establish a comprehensive framework allowing the implementation of these new findings at the population level...
August 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28819101/hypotension-in-icu-patients-receiving-vasopressor-therapy
#12
Bryce Yapps, Sungtae Shin, Ramin Bighamian, Jill Thorsen, Colleen Arsenault, Sadeq A Quraishi, Jin-Oh Hahn, Andrew T Reisner
Vasopressor infusion (VPI) is used to treat hypotension in an ICU. We studied compliance with blood pressure (BP) goals during VPI and whether a statistical model might be efficacious for advance warning of impending hypotension, compared with a basic hypotension threshold alert. Retrospective data were obtained from a public database. Studying adult ICU patients receiving VPI at submaximal dosages, we analyzed characteristics of sustained hypotension episodes (>15 min) and then developed a logistic regression model to predict hypotension episodes using input features related to BP trends...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28816078/pathobiology-of-lp-a-in-calcific-aortic-valve-disease
#13
Patrick Mathieu, Benoit J Arsenault, Marie-Chloé Boulanger, Yohan Bossé, Marlys L Koschinsky
Calcific aortic valve disease (CAVD) is the most prevalent heart valve disorder. Gene variant in the LPA gene, which encodes for apolipoprotein(a), has been associated at the genome-wide level with CAVD. The process whereby Lp(a) promotes the development of CAVD is under intensive investigation and recent data have shed important insights into disease biology. In this regard, autotaxin (ATX), a lysophospholipase D, interacts with Lp(a) and promotes the mineralization of the aortic valve. Areas covered: In this paper, we are reviewing the biology of Lp(a) and the latest discoveries about the molecular processes that link this lipoprotein with the development of CAVD including the role of ATX...
August 24, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28796024/addressing-occupational-fatigue-in-nurses-current-state-of-fatigue-risk-management-in-hospitals-part-1
#14
Linsey M Steege, Barbara J Pinekenstein, Jessica G Rainbow, Élise Arsenault Knudsen
OBJECTIVE: The aim of this study was to describe the current state of fatigue risk management systems (FRMS) to address nurse fatigue in hospitals. BACKGROUND: Although multiple studies have examined sources and consequences of fatigue, little is known about the current state of FRMS. METHODS: This study used a sequential exploratory mixed-method design including a survey of nurse leaders from across the United States. FINDINGS: Although healthcare organizations have implemented strategies to address fatigue, most participants' organizations did not have a formal FRMS in place...
September 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28768102/chemical-approaches-to-intervening-in-ubiquitin-specific-protease-7-usp7-function-for-oncology-and-immune-oncology-therapies
#15
Jian Wu, Suresh Kumar, Feng Wang, Hui Wang, Lijia Chen, Patrick Arsenault, Michael Mattern, Joseph Weinstock
USP7, the most widely studied among the nearly 100 deubiquitinating enzymes, supports cancer by positively affecting tumor growth and negatively affecting the patient's immune response to tumors. Great interest exists, therefore, in developing USP7 inhibitors for clinical evaluation. While the proteasome inhibitor field has enjoyed clinical success, very few clinically appropriate effectors of deubiquitinating (protease) or ubiquitinating (ligase) enzymes have appeared. The ubiquitin protease/ligase field is moving from the initial discovery of potent, selective modulators with cell proof of concept and/or in vivo activity to the optimization of these molecules to impart drug-like properties or the discovery of new inhibitor scaffolds by improved screening or rational design...
August 2, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28735508/initiating-insulin-how-to-help-people-with-type-2-diabetes-start-and-continue-insulin-successfully
#16
William H Polonsky, Joyce Arsenault, Lawrence Fisher, Pamela Kushner, Eden M Miller, Teresa L Pearson, Mariusz Tracz, Stewart Harris, Norbert Hermanns, Bernd-M Scholz, Robyn K Pollom, Magaly Perez-Nieves, Roy Daniel Pollom, Irene Hadjiyianni
No abstract text is available yet for this article.
August 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28732315/total-and-ionized-magnesium-testing-in-the-surgical-intensive-care-unit-opportunities-for-improved-laboratory-and-pharmacy-utilization
#17
Daniel Dante Yeh, Nalin Chokengarmwong, Yuchiao Chang, Liyang Yu, Colleen Arsenault, Joseph Rudolf, Elizabeth Lee-Lewandrowski, Kent Lewandrowski
PURPOSE: Ionized fraction (iMg) is the physiologically active form of magnesium (Mg); total Mg may not accurately reflect iMg status. Erroneously "low" Mg levels may result in unnecessary repetitive testing. MATERIALS AND METHODS: From 11/2015 to 01/2016, patients ordered for Mg from a pilot ICU also had iMg tested. Weighted kappa statistic was used to assess agreement between Mg categories (low, normal, high). Predictors of unnecessary repeated Mg testing and repletion using data were explored through logistic regression models using GEE techniques to account for repeated measurements in both bivariate and multivariable analyses...
July 11, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28716206/contextual-herd-factors-associated-with-cow-culling-risk-in-qu%C3%A3-bec-dairy-herds-a-multilevel-analysis
#18
Denis Haine, Hector Delgado, Roger Cue, Asheber Sewalem, Kevin Wade, René Lacroix, Daniel Lefebvre, Julie Arsenault, Émile Bouchard, Jocelyn Dubuc
Several health disorders, such as milk fever, displaced abomasum, and mastitis, as well as impaired reproductive performance, are known risk factors for the removal of affected cows from a dairy herd. While cow-level risk factors are well documented in the literature, herd-level associations have been less frequently investigated. The objective of this study was to investigate the effect of cow- and herd-level determinants on variations in culling risk in Québec dairy herds: whether herd influences a cow's culling risk...
September 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28641153/lipoprotein-a-and-coronary-atheroma-progression-rates-during-long-term-high-intensity-statin-therapy-insights-from-saturn
#19
Rishi Puri, Christie M Ballantyne, Ron C Hoogeveen, Mingyuan Shao, Philip Barter, Peter Libby, M John Chapman, Raimund Erbel, Benoit J Arsenault, Joel S Raichlen, Steven E Nissen, Stephen J Nicholls
BACKGROUND & AIMS: Lipoprotein(a) [Lp(a)] is a low-density lipoprotein (LDL)-like particle that associates with major adverse cardiovascular events (MACE). We examined relationships between Lp(a) measurements and changes in coronary atheroma volume following long-term maximally-intensive statin therapy in coronary artery disease patients. METHODS: Study of coronary atheroma by intravascular ultrasound: Effect of Rosuvastatin Versus Atorvastatin (SATURN) used serial intravascular ultrasound measures of coronary atheroma volume in patients treated with rosuvastatin 40 mg or atorvastatin 80 mg for 24 months...
June 15, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28635961/hypoxia-induced-mobilization-of-nhe6-to-the-plasma-membrane-triggers-endosome-hyperacidification-and-chemoresistance
#20
Fabrice Lucien, Pierre-Paul Pelletier, Roxane R Lavoie, Jean-Michel Lacroix, Sébastien Roy, Jean-Luc Parent, Dominique Arsenault, Kelly Harper, Claire M Dubois
The pH-dependent partitioning of chemotherapeutic drugs is a fundamental yet understudied drug distribution mechanism that may underlie the low success rates of current approaches to counter multidrug resistance (MDR). This mechanism is influenced by the hypoxic tumour microenvironment and results in selective trapping of weakly basic drugs into acidified compartments such as the extracellular environment. Here we report that hypoxia not only leads to acidification of the tumour microenvironment but also induces endosome hyperacidification...
June 21, 2017: Nature Communications
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