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https://www.readbyqxmd.com/read/29440006/apob-apoa-i-ratio-is-associated-with-faster-hemodynamic-progression-of-aortic-stenosis-results-from-the-progressa-metabolic-determinants-of-the-progression-of-aortic-stenosis-study
#1
Lionel Tastet, Romain Capoulade, Mylène Shen, Marie-Annick Clavel, Nancy Côté, Patrick Mathieu, Marie Arsenault, Élisabeth Bédard, Alexe Tremblay, Marilie Samson, Yohan Bossé, Jean G Dumesnil, Benoit J Arsenault, Jonathan Beaudoin, Mathieu Bernier, Jean-Pierre Després, Philippe Pibarot
BACKGROUND: Previous studies reported that middle-aged patients with atherogenic lipoprotein-lipid profile exhibit faster progression of aortic valve stenosis (AS). The ratio of apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) reflects the balance between atherogenic and anti-atherogenic lipoproteins. The aim of this study was to examine the association between apoB/apoA-I ratio and AS hemodynamic progression and to determine whether this association varies according to age. METHODS AND RESULTS: A total of 159 patients (66±13 years, 73% men) with AS were prospectively recruited in the PROGRESSA (Metabolic Determinants of the Progression of Aortic Stenosis) study...
February 10, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29391386/extended-linkers-improve-the-detection-of-protein-protein-interactions-ppis-by-dihydrofolate-reductase-protein-fragment-complementation-assay-dhfr-pca-in-living-cells
#2
Andrée-Ève Chrétien, Isabelle Gagnon-Arsenault, Alexandre K Dubé, Xavier Barbeau, Philippe C Després, Claudine Lamothe, Anne-Marie Dion-Côté, Patrick Lagüe, Christian R Landry
Understanding the function of cellular systems requires describing how proteins assemble with each other into transient and stable complexes and to determine their spatial relationships. Among the tools available to perform these analyses on a large scale is Protein-fragment Complementation Assay based on the dihydrofolate reductase (DHFR PCA). Here we test how longer linkers between the fusion proteins and the reporter fragments affect the performance of this assay. We investigate the architecture of the RNA polymerases, the proteasome and the conserved oligomeric Golgi (COG) complexes in living cells and performed large-scale screens with these extended linkers...
February 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29373241/french-translation-and-cross-cultural-adaptation-of-the-michigan-hand-outcomes-questionnaire-and-the-brief-michigan-hand-outcomes-questionnaire
#3
J I Efanov, J J Shine, R Darwich, C Besner Morin, J Arsenault, P G Harris, A M Danino, A Izadpanah
Patient-Reported Outcome Measures (PROMs) are important clinical devices for evaluating injuries and surgeries of the hand. However, some of the most widely used questionnaires, such as the MHQ and bMHQ, are currently unavailable in French, which prevents them from being used in the French Canadian province of Quebec as well as in other French-speaking nations. We therefore intend to develop valid and culturally adapted French translations of the afore-mentioned questionnaires. Two independent bilingual translators converted all English questionnaires to French...
January 17, 2018: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29336671/the-indirect-effect-of-ethnic-identity-on-marijuana-use-through-school-engagement-an-african-american-high-school-sample
#4
Chelsea E Arsenault, Sycarah Fisher, Danelle Stevens-Watkins, Jessica Barnes-Najor
BACKGROUND: African American marijuana use is associated with many negative social, emotional, and health-related consequences. Of significance, over recent years this population has shown an increase in use. In the literature, ethnic identity and school engagement are prominent protective factors against substance use. OBJECTIVE: This study will examine how these protective factors are related, specifically whether ethnic identity mitigates risk through school engagement to reduce marijuana use...
January 16, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29300915/in-vivo-identification-of-thick-thin-and-pale-stripes-of-macaque-area-v2-using-submillimeter-resolution-f-mri-at-3-t
#5
Xiaolian Li, Qi Zhu, Thomas Janssens, John T Arsenault, Wim Vanduffel
Primate area V2 contains a repetitive pattern of thick, thin and pale cytochrome oxidase stripes that are characterized by largely discrete in- and output channels, as well as differences in function, and myelo- and cytoarchitecture. Stripes have been identified mainly using microscope-based imaging of tiny portions of superficially located V2, or by postmortem methods, hence, the quest for (quasi) noninvasive tools to study these mesoscale functional units. Only recently, stripe-like V2 patterns have been demonstrated in humans with high-field (functional) magnetic resonance imaging (f)MRI, but in both such studies only 2 stripe compartments could be identified...
December 28, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29249317/chicken-macrophages-infected-with-salmonella-s-enteritidis-or-s-heidelberg-produce-differential-responses-in-immune-and-metabolic-signaling-pathways
#6
Haiqi He, Ryan J Arsenault, Kenneth J Genovese, Casey Johnson, Michael H Kogut
Protein kinases act in coordination with phosphatases to control protein phosphorylation and regulate signaling pathways and cellular processes involved in nearly every functions of cell life. Salmonella are known to manipulate the host kinase network to gain entrance and survive inside host cells. The effect of Salmonella infection on the host kinase network has been studied in mammalian cells, but information is largely lacking in chicken immune cells. Our previous study indicated that chicken macrophage cells respond differentially to different Salmonella strains...
January 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29228930/gene-expression-analysis-in-asthma-using-a-targeted-multiplex-array
#7
Christopher D Pascoe, Ma'en Obeidat, Bryna A Arsenault, Yunlong Nie, Stephanie Warner, Dorota Stefanowicz, Samuel J Wadsworth, Jeremy A Hirota, S Jasemine Yang, Delbert R Dorscheid, Chris Carlsten, Tillie L Hackett, Chun Y Seow, Peter D Paré
BACKGROUND: Gene expression changes in the structural cells of the airways are thought to play a role in the development of asthma and airway hyperresponsiveness. This includes changes to smooth muscle contractile machinery and epithelial barrier integrity genes. We used a targeted gene expression arrays to identify changes in the expression and co-expression of genes important in asthma pathology. METHODS: RNA was isolated from the airways of donor lungs from 12 patients with asthma (8 fatal) and 12 non-asthmatics controls and analyzed using a multiplexed, hypothesis-directed platform to detect differences in gene expression...
December 11, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29203496/extended-linkers-improve-the-detection-of-ppis-by-dhfr-pca-in-living-cells
#8
Andree-Eve Chretien, Isabelle Gagnon-Arsenault, Alexandre K Dubé, Xavier Barbeau, Philippe C Després, Claudine Lamothe, Anne-Marie Dion-Coté, Patrick Lague, Christian Landry
Understanding the function of cellular systems requires describing how proteins assemble with each other into transient and stable complexes and to determine their spatial relationships. Among the tools available to perform these analyses on a large scale is the Protein-fragment Complementation Assay based on the dihydrofolate reductase (DHFR PCA). Here we test how longer linkers between the fusion proteins and the reporter fragments affect the performance of this assay. We investigate the architecture of the RNA polymerases, the proteasome and the conserved oligomeric Golgi (COG) complexes in living cells and performed large-scale screens with these extended linkers...
December 4, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29157366/culling-from-the-actors-perspectives-decision-making-criteria-for-culling-in-qu%C3%A3-bec-dairy-herds-enrolled-in-a-veterinary-preventive-medicine-program
#9
Denis Haine, Roger Cue, Asheber Sewalem, Kevin Wade, René Lacroix, Daniel Lefebvre, Jonathan Rushton, Julie Arsenault, Émile Bouchard, Jocelyn Dubuc
The series of events leading to the decision to cull a cow is complex, involving both individual-level and herd-level factors. While the decision is guided by financial returns, it is also influenced by social and psychological factors. Research studies on the motivational and behavioural aspects of farmers' decision utility are sparse, and nonexistent regarding culling expectations and its decision process. Our goal was to identify shared criteria on culling decisions held by dairy producers and farm advisers, with the help of the Q-methodology...
December 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29138462/the-antibacterial-and-anti-inflammatory-activity-of-chicken-cathelicidin-2-combined-with-exogenous-surfactant-for-the-treatment-of-cystic-fibrosis-associated-pathogens
#10
Brandon J H Banaschewski, Brandon Baer, Christina Arsenault, Teah Jazey, Edwin J A Veldhuizen, Johan Delport, Tracey Gooyers, James F Lewis, Henk P Haagsman, Ruud A W Veldhuizen, Cory Yamashita
Cystic fibrosis (CF) is characterized by recurrent airway infections with antibiotic-resistant bacteria and chronic inflammation. Chicken cathelicin-2 (CATH-2) has been shown to exhibit antimicrobial activity against antibiotic-resistant bacteria and to reduce inflammation. In addition, exogenous pulmonary surfactant has been suggested to enhance pulmonary drug delivery. It was hypothesized that CATH-2 when combined with an exogenous surfactant delivery vehicle, bovine lipid extract surfactant (BLES), would exhibit antimicrobial activity against CF-derived bacteria and downregulate inflammation...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29110186/patient-safety-ward-round-checklist-via-an-electronic-app-implications-for-harm-prevention
#11
C Keller, S Arsenault, M Lamothe, S R Bostan, R O'Donnell, J Harbison, C P Doherty
INTRODUCTION: Patient safety is a value at the core of modern healthcare. Though awareness in the medical community is growing, implementing systematic approaches similar to those used in other high reliability industries is proving difficult. The aim of this research was twofold, to establish a baseline for patient safety practices on routine ward rounds and to test the feasibility of implementing an electronic patient safety checklist application. METHODS: Two research teams were formed; one auditing a medical team to establish a procedural baseline of "usual care" practice and an intervention team concurrently was enforcing the implementation of the checklist...
November 6, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29103916/effect-of-atorvastatin-cholesterol-ester-transfer-protein-inhibition-and-diabetes-mellitus-on-circulating-proprotein-subtilisin-kexin-type-9-and-lipoprotein-a-levels-in-patients-at-high-cardiovascular-risk
#12
Benoit J Arsenault, Francine Petrides, Fatiha Tabet, Weihang Bao, G Kees Hovingh, S Matthijs Boekholdt, Stéphane Ramin-Mangata, Olivier Meilhac, David DeMicco, Kerry-Anne Rye, David D Waters, John J P Kastelein, Philip Barter, Gilles Lambert
BACKGROUND: Proprotein subtilisin kexin type 9 (PCSK9) and lipoprotein (a) [Lp(a)] levels are causative risk factors for coronary heart disease. OBJECTIVES: The objective of the study was to determine the impact of lipid-lowering treatments on circulating PCSK9 and Lp(a). METHODS: We measured PCSK9 and Lp(a) levels in plasma samples from Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events trial patients with coronary heart disease and/or type II diabetes (T2D) mellitus...
October 12, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29100654/do-oxidized-lipoproteins-cause-atherosclerotic-cardiovascular-diseases
#13
EDITORIAL
Benoit J Arsenault, Raphaëlle Bourgeois, Patrick Mathieu
No abstract text is available yet for this article.
October 6, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29094623/problem-analysis-in-community-violence-assessment-revealing-early-childhood-trauma-as-a-driver-of-youth-and-gang-violence
#14
Laurie Ross, Samantha Arsenault
Problem analysis conducted by a university-based research partner can provide communities with data-driven options to address the local drivers of serious youth and gang violence. Situated in Worcester, Massachusetts, this article describes how subsequent to early childhood trauma being identified as a potential driver of adolescent and young adult violence; problem analysis using local data confirmed that being the victim or witness of a traumatic incident before the age of 12 years was significantly correlated with involvement in violence in adolescence or young adulthood...
November 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29092112/early-activation-of-growth-pathways-in-mitral-leaflets-exposed-to-aortic-regurgitation-new-insights-from-an-animal-model
#15
Ons Marsit, Olivier Royer, Marie-Claude Drolet, Marie Arsenault, Jacques Couet, Stéphane Morin, Robert A Levine, Philippe Pibarot, Jonathan Beaudoin
BACKGROUND: Mitral leaflet enlargement in patients with chronic aortic regurgitation (AR) has been identified as an adaptive mechanism potentially able to prevent functional mitral regurgitation (FMR) in response to left ventricular (LV) dilatation. The timing of valve enlargement is not known, and the related mechanisms are largely unexplored. METHODS: AR was induced in 58 rats, and another 54 were used as sham controls. Animals were euthanized at different time points after AR creation (48 h, one week, and three months), and AR severity, FMR and LV dilatation were assessed using echocardiography...
May 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29083303/deep-transcriptome-annotation%C3%A2-enables-the-discovery-and-functional-characterization-of-cryptic-small-proteins
#16
Sondos Samandi, Annie V Roy, Vivian Delcourt, Jean-François Lucier, Jules Gagnon, Maxime C Beaudoin, Benoît Vanderperre, Marc-André Breton, Julie Motard, Jean-François Jacques, Mylène Brunelle, Isabelle Gagnon-Arsenault, Isabelle Fournier, Aïda Ouangraoua, Darel J Hunting, Alan A Cohen, Christian R Landry, Michelle S Scott, Xavier Roucou
Recent functional, proteomic and ribosome profiling studies in eukaryotes have concurrently demonstrated the translation of alternative open reading frames (altORFs) in addition to annotated protein coding sequences (CDSs). We show that a large number of small proteins could in fact be coded by these altORFs. The putative alternative proteins translated from altORFs have orthologs in many species and contain functional domains. Evolutionary analyses indicate that altORFs often show more extreme conservation patterns than their CDSs...
October 30, 2017: ELife
https://www.readbyqxmd.com/read/29079561/forward-left-ventricular-ejection-fraction-a-simple-risk-marker-in-patients-with-primary-mitral-regurgitation
#17
Marlène Dupuis, Haïfa Mahjoub, Marie-Annick Clavel, Nancy Côté, Oumhani Toubal, Lionel Tastet, Jean G Dumesnil, Kim O'Connor, Abdellaziz Dahou, Christophe Thébault, Catherine Bélanger, Jonathan Beaudoin, Marie Arsenault, Mathieu Bernier, Philippe Pibarot
BACKGROUND: The timing of mitral valve surgery in asymptomatic patients with primary mitral regurgitation (MR) is controversial. We hypothesized that the forward left ventricular (LV) ejection fraction (LVEF; ie, LV outflow tract stroke volume divided by LV end-diastolic volume) is superior to the total LVEF to predict outcomes in MR. The objective of this study was to examine the association between echocardiographic parameters of MR severity and LV function and outcomes in patients with MR...
October 27, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29077905/influence-of-different-yeast-cell-wall-preparations-and-their-components-on-performance-and-immune-and-metabolic-pathways-in-clostridium-perfringens-challenged-broiler-chicks
#18
Mohammed M Hashim, Ryan J Arsenault, James A Byrd, Michael H Kogut, Morouj Al-Ajeeli, Christopher A Bailey
A study was conducted to evaluate the influence of the purification of yeast cell wall (YCW) preparations on broiler performance and immunogenic and metabolic pathways under microbial challenge. A total of 240 (day old) chicks were distributed among two battery brooder units (48 pens; 5 birds/pen; 8 replicates/treatment). A basal starter diet was divided into 5 batches to create 6 dietary treatments; non-challenge (NCh-C) and challenge (Ch-C) controls, semi-purified YCW containing cytosol contents (SPYCW; 250 mg/kg), purified YCW (PYCW; 250 mg/kg), 50% purified beta-glucan (BG; 130 mg/kg), and 99...
October 25, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053819/changes-in-immune-and-metabolic-gut-response-in-broilers-fed-%C3%AE-mannanase-in-%C3%AE-mannan-containing-diets
#19
R J Arsenault, J T Lee, R Latham, B Carter, M H Kogut
β-galactomannans found in soy-based broiler feed are known to cause physiological effects that are hypothesized to be related to gut inflammation. Previous studies have shown that the incorporation of β-mannanase in the diet or as a supplement results in improvements to certain performance parameters related to gut health and feed conversion. Using kinome analysis, we characterized the mechanism of β-galactomannan activity and supplementation with β-mannanase on the gut of commercial broilers to understand the mode of action...
September 14, 2017: Poultry Science
https://www.readbyqxmd.com/read/28973091/association-of-paravalvular-regurgitation-with-1-year-outcomes-after-transcatheter-aortic-valve-replacement-with-the-sapien-3-valve
#20
Philippe Pibarot, Rebecca T Hahn, Neil J Weissman, Marie Arsenault, Jonathan Beaudoin, Mathieu Bernier, Abdellaziz Dahou, Omar K Khalique, Federico M Asch, Oumhani Toubal, Jonathon Leipsic, Philipp Blanke, Feifan Zhang, Rupa Parvataneni, Maria Alu, Howard Herrmann, Raj Makkar, Michael Mack, Richard Smalling, Martin Leon, Vinod H Thourani, Susheel Kodali
Importance: Moderate/severe and even mild paravalvular regurgitation (PVR) are associated with increased mortality following transcatheter aortic valve replacement (TAVR) with first and second generations of transcatheter valves. Objective: To examine the incidence, evolution, and effect on 1-year outcomes of PVR following TAVR with a third-generation balloon-expandable transcatheter heart valve. Design, Setting, and Participants: Prespecified analysis of PVR in the Placement of Aortic Transcatheter Valves (PARTNER) II SAPIEN 3 trial, conducted between October 1, 2013, and September 3, 2014...
November 1, 2017: JAMA Cardiology
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