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https://www.readbyqxmd.com/read/28319871/autoantibodies-and-immune-complexes-to-oxidation-specific-epitopes-and-progression-of-aortic-stenosis-results-from-the-astronomer-trial
#1
Romain Capoulade, Kwan L Chan, Patrick Mathieu, Yohan Bossé, Jean G Dumesnil, James W Tam, Koon K Teo, Xiaohong Yang, Joseph L Witztum, Benoit J Arsenault, Jean-Pierre Després, Philippe Pibarot, Sotirios Tsimikas
BACKGROUND AND AIMS: Elevated levels of lipoprotein(a) [Lp(a)] and oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) predict the progression of pre-existing mild-to-moderate calcific aortic valve stenosis (CAVS). Whether indirect markers of oxidation-specific epitopes (OSE) are also predictive is not known. The association between IgG and IgM autoantibodies and malondialdehyde-modified low density lipoprotein (MDA-LDL) and IgG and IgM apolipoprotein B immune complexes (apoB-IC), and the hemodynamic progression rate of CAVS was determined in the ASTRONOMER (Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin, NCT00800800) trial...
March 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28290255/feeding-by-leucopis-argenticollis-and-leucopis-piniperda-diptera-chamaemyiidae-from-the-western-usa-on-adelges-tsugae-hemiptera-adelgidae-in-the-eastern-usa
#2
K Motley, N P Havill, A L Arsenault-Benoit, A E Mayfield, D S Ott, D Ross, M C Whitmore, K F Wallin
Leucopis argenticollis (Zetterstedt) and Leucopis piniperda (Malloch) are known to feed on the lineage of Adelges tsugae Annand that is native to western North America, but it is not known if they will survive on the lineage that was introduced from Japan to the eastern USA. In 2014, western Leucopis spp. larvae were brought to the laboratory and placed on A. tsugae collected in either Washington (North American A. tsugae lineage) or Connecticut (Japanese lineage). There were no significant differences in survival or developmental times between flies reared on the two different adelgid lineages...
March 14, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28276874/corrections-to-once-daily-controlled-release-pregabalin-in-the-treatment-of-patients-with-fibromyalgia-a-phase-iii-double-blind-randomized-withdrawal-placebo-controlled-study
#3
Lesley M Arnold, Pierre Arsenault, Cynthia Huffman, Jeffrey Patrick, Michael Messig, Marci Chew, Luis Sanin, Joseph Scavone, Lynne Pauer, Andrew Clair
No abstract text is available yet for this article.
February 10, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28250513/an-equity-dashboard-to-monitor-vaccination-coverage
#4
Catherine Arsenault, Sam Harper, Arijit Nandi, José M Mendoza Rodríguez, Peter M Hansen, Mira Johri
Equity monitoring is a priority for Gavi, the Vaccine Alliance, and for those implementing The2030 agenda for sustainable development. For its new phase of operations, Gavi reassessed its approach to monitoring equity in vaccination coverage. To help inform this effort, we made a systematic analysis of inequalities in vaccination coverage across 45 Gavi-supported countries and compared results from different measurement approaches. Based on our findings, we formulated recommendations for Gavi's equity monitoring approach...
February 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28244184/exploring-nurse-leader-fatigue-a-mixed-methods-study
#5
Linsey M Steege, Barbara J Pinekenstein, Élise Arsenault Knudsen, Jessica G Rainbow
AIM: To describe hospital nurse leaders' experiences of fatigue. BACKGROUND: Fatigue is a critical challenge in nursing. Existing literature focuses on staff nurse fatigue, yet nurse leaders are exposed to high demands that may contribute to fatigue and associated risks to patient, nurse and organisational outcomes. METHODS: A mixed method approach comprising semi-structured interviews and the Occupational Fatigue Exhaustion Recovery scale with 21 nurse administrators (10 nurse managers and 11 nurse executives) from hospitals in a Midwestern state...
February 27, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/28202900/cardiovascular-disease-prevention-lifestyle-attenuation-of-genetic-risk
#6
Benoit J Arsenault, Jean-Pierre Després
No abstract text is available yet for this article.
April 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28202639/dietary-protein-intake-in-young-children-in-selected-low-income-countries-is-generally-adequate-in-relation-to-estimated-requirements-for-healthy-children-except-when-complementary-food-intake-is-low
#7
Joanne E Arsenault, Kenneth H Brown
Background: Previous research indicates that young children in low-income countries (LICs) generally consume greater amounts of protein than published estimates of protein requirements, but this research did not account for protein quality based on the mix of amino acids and the digestibility of ingested protein.Objective: Our objective was to estimate the prevalence of inadequate protein and amino acid intake by young children in LICs, accounting for protein quality.Methods: Seven data sets with information on dietary intake for children (6-35 mo of age) from 6 LICs (Peru, Guatemala, Ecuador, Bangladesh, Uganda, and Zambia) were reanalyzed to estimate protein and amino acid intake and assess adequacy...
February 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28195575/a-land-data-assimilation-system-for-sub-saharan-africa-food-and-water-security-applications
#8
Amy McNally, Kristi Arsenault, Sujay Kumar, Shraddhanand Shukla, Pete Peterson, Shugong Wang, Chris Funk, Christa D Peters-Lidard, James P Verdin
Seasonal agricultural drought monitoring systems, which rely on satellite remote sensing and land surface models (LSMs), are important for disaster risk reduction and famine early warning. These systems require the best available weather inputs, as well as a long-term historical record to contextualize current observations. This article introduces the Famine Early Warning Systems Network (FEWS NET) Land Data Assimilation System (FLDAS), a custom instance of the NASA Land Information System (LIS) framework. The FLDAS is routinely used to produce multi-model and multi-forcing estimates of hydro-climate states and fluxes over semi-arid, food insecure regions of Africa...
February 14, 2017: Scientific Data
https://www.readbyqxmd.com/read/28183979/gene-duplication-can-impart-fragility-not-robustness-in-the-yeast-protein-interaction-network
#9
Guillaume Diss, Isabelle Gagnon-Arsenault, Anne-Marie Dion-Coté, Hélène Vignaud, Diana I Ascencio, Caroline M Berger, Christian R Landry
The maintenance of duplicated genes is thought to protect cells from genetic perturbations, but the molecular basis of this robustness is largely unknown. By measuring the interaction of yeast proteins with their partners in wild-type cells and in cells lacking a paralog, we found that 22 out of 56 paralog pairs compensate for the lost interactions. An equivalent number of pairs exhibit the opposite behavior and require each other's presence for maintaining their interactions. These dependent paralogs generally interact physically, regulate each other's abundance, and derive from ancestral self-interacting proteins...
February 10, 2017: Science
https://www.readbyqxmd.com/read/28182723/antibody-responses-to-borrelia-burgdorferi-detected-by-western-blot-vary-geographically-in-canada
#10
Nicholas H Ogden, Julie Arsenault, Todd F Hatchette, Samir Mechai, L Robbin Lindsay
Lyme disease is emerging in eastern and central Canada, and most cases are diagnosed using the two-tier serological test (Enzyme Immuno Assay [EIA] followed by Western blot [WB]). Simplification of this algorithm would be advantageous unless it impacts test performance. In this study, accuracy of individual proteins of the IgG WB algorithm in predicting the overall test result in samples from Canadians was assessed. Because Borrelia burgdorferi strains vary geographically in Canada, geographic variations in serological responses were also explored...
2017: PloS One
https://www.readbyqxmd.com/read/28145745/dietary-intake-of-dha-and-epa-in-a-group-of-pregnant-women-in-the-moncton-area
#11
Nicole Arsenault Bishop, Caroline P Leblanc
PURPOSE: To compare docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and fish intake of pregnant women at 30 weeks of gestation to current recommendations and to determine the factors associated with omega-3 (ω-3) intake. METHODS: A food frequency questionnaire was completed by 54 women (54/131 = 41%) at 30 ± 0.8 weeks gestation. Supplement intake, sociodemographic characteristics, and ω-3 food habits were evaluated. RESULTS: Among this high socioeconomic status (SES) group, 66...
February 1, 2017: Canadian Journal of Dietetic Practice and Research
https://www.readbyqxmd.com/read/28118982/sox4-regulates-gonad-morphogenesis-and-promotes-male-germ-cell-differentiation-in-mice
#12
Liang Zhao, Michel Arsenault, Ee Ting Ng, Enya Longmuss, Tevin Chui-Ying Chau, Sunny Hartwig, Peter Koopman
The group C SOX transcription factors SOX4, -11 and -12 play important and mutually overlapping roles in development of a number of organs. Here, we examined the role of SoxC genes during gonadal development in mice. All three genes were expressed in developing gonads of both sexes, predominantly in somatic cells, with Sox4 being most strongly expressed. Sox4 deficiency resulted in elongation of both ovaries and testes, and an increased number of testis cords. While female germ cells entered meiosis normally, male germ cells showed reduced levels of differentiation markers Nanos2 and Dnmt3l and increased levels of pluripotency genes Cripto and Nanog, suggesting that SOX4 may normally act to restrict the pluripotency period of male germ cells and ensure their proper differentiation...
March 1, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28102300/neural-correlates-of-speech-segregation-based-on-formant-frequencies-of-adjacent-vowels
#13
Claude Alain, Jessica S Arsenault, Linda Garami, Gavin M Bidelman, Joel S Snyder
The neural substrates by which speech sounds are perceptually segregated into distinct streams are poorly understood. Here, we recorded high-density scalp event-related potentials (ERPs) while participants were presented with a cyclic pattern of three vowel sounds (/ee/-/ae/-/ee/). Each trial consisted of an adaptation sequence, which could have either a small, intermediate, or large difference in first formant (Δf1) as well as a test sequence, in which Δf1 was always intermediate. For the adaptation sequence, participants tended to hear two streams ("streaming") when Δf1 was intermediate or large compared to when it was small...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28076920/effectiveness-of-impact-ability-to-improve-safety-and-self-advocacy-skills-in-students-with-disabilities-follow-up-study
#14
Eileen M Dryden, Jeffrey Desmarais, Lisa Arsenault
BACKGROUND: Research shows that individuals with disabilities are more likely to experience abuse than their peers without disabilities. Yet, few evidenced-based abuse prevention interventions exist. This study examines whether positive outcomes identified previously in an evaluation of IMPACT:Ability were maintained 1 year later. METHODS: A survey measuring safety and self-advocacy knowledge, confidence, and behaviors among special education high-school students was administered 12 months post-training...
February 2017: Journal of School Health
https://www.readbyqxmd.com/read/28069359/monitoring-equity-in-vaccination-coverage-a-systematic-analysis-of-demographic-and-health-surveys-from-45-gavi-supported-countries
#15
Catherine Arsenault, Sam Harper, Arijit Nandi, José M Mendoza Rodríguez, Peter M Hansen, Mira Johri
OBJECTIVES: (1) To conduct a systematic analysis of inequalities in childhood vaccination coverage in Gavi-supported countries; (2) to comparatively assess alternative measurement approaches and how they may affect cross-country comparisons of the level of inequalities. METHODS: Using the most recent Demographic and Health Surveys (2005-2014) in 45 Gavi-supported countries, we measured inequalities in vaccination coverage across seven dimensions of social stratification and of vulnerability to poor health outcomes...
January 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28064154/impact-of-left-ventricular-remodelling-patterns-on-outcomes-in-patients-with-aortic-stenosis
#16
Romain Capoulade, Marie-Annick Clavel, Florent Le Ven, Abdellaziz Dahou, Christophe Thébault, Lionel Tastet, Mylène Shen, Marie Arsenault, Élisabeth Bédard, Jonathan Beaudoin, Kim O'Connor, Mathieu Bernier, Jean G Dumesnil, Philippe Pibarot
AIMS: The objective of this study was to examine the association between the different patterns of left ventricular (LV) remodelling/hypertrophy on all-cause and cardiovascular mortality in patients with aortic stenosis (AS). METHODS AND RESULTS: In total, 747 consecutive patients (69 ± 14 years, 57% men) with AS and preserved LV ejection fraction were included in this study. According to LV mass index and relative wall thickness, patients were classified into four LV patterns: normal, concentric remodelling (CR), concentric hypertrophy (CH), and eccentric hypertrophy (EH)...
January 6, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28040289/two-year-outcomes-after-percutaneous-coronary-intervention-of-calcified-lesions-with-drug-eluting-stents
#17
Philippe Généreux, Björn Redfors, Bernhard Witzenbichler, Marie-Pier Arsenault, Giora Weisz, Thomas D Stuckey, Michael J Rinaldi, Franz-Josef Neumann, D Christopher Metzger, Timothy D Henry, David A Cox, Peter L Duffy, Ernest L Mazzaferri, Dominic P Francese, Guillaume Marquis-Gravel, Gary S Mintz, Ajay J Kirtane, Akiko Maehara, Roxana Mehran, Gregg W Stone
BACKGROUND: Percutaneous coronary intervention (PCI) of lesions with coronary arterial calcification (CAC) is common and has been historically associated with an increased risk of adverse events. Whether the association between target lesion calcification (CAC) and outcomes differ across drug-eluting stent generation or between patients with high vs. low residual platelet reactivity (PR) remains unknown. We assessed the association of CAC with adverse ischemic and bleeding events among patients undergoing contemporary PCI with drug-eluting stents (DES)...
March 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28030378/does-lifestyle-contribute-to-disease-severity-in-patients-with-inherited-lipid-disorders
#18
Benoit J Arsenault, Nicolas Perrot, Patrick Couture
PURPOSE OF REVIEW: Patients with familial hypercholesterolemia, familial combined hyperlipidemia and hyperlipoprotein(a) are at high cardiovascular risk. Increasing evidence suggest that lifestyle-related risk factors such as physical inactivity, and poor diet quality could influence cardiovascular risk in these patients. Our objective is to review the evidence that supports the role of lifestyle-related factors in the prediction of cardiovascular risk in patients with inherited lipid disorders...
December 24, 2016: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28009652/positive-and-negative-affect-is-related-to-experiencing-chest-pain-during-exercise-induced-myocardial-ischemia
#19
Philippe Stébenne, Simon L Bacon, Anthony Austin, Nicola J Paine, André Arsenault, Catherine Laurin, Bernard Meloche, Jennifer Gordon, Jocelyn Dupuis, Kim L Lavoie
OBJECTIVES: Silent myocardial ischemia is thought to be associated with worse cardiovascular outcomes due to a lack of perception of pain cues that initiate treatment seeking. Negative affect (NA) has been associated with increased pain reporting and positive affect (PA) with decreased pain reporting, but these psychological factors have not been examined within the context of myocardial ischemia. This study evaluated the associations between PA, NA, and chest pain reporting in patients with and without ischemia during exercise testing...
December 22, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27998826/ideal-cardiovascular-health-influences-cardiovascular-disease-risk-associated-with-high-lipoprotein-a-levels-and-genotype-the-epic-norfolk-prospective-population-study
#20
Nicolas Perrot, Rutger Verbeek, Manjinder Sandhu, S Matthijs Boekholdt, G Kees Hovingh, Nicholas J Wareham, Kay-Tee Khaw, Benoit J Arsenault
BACKGROUND AND AIMS: Lipoprotein(a) (Lp[a]) is a strong genetic risk factor for cardiovascular disease (CVD). The American Heart Association has prioritised seven cardiovascular health metrics to reduce the burden of CVD: body mass index, healthy diet, physical activity, smoking status, blood pressure, diabetes and cholesterol levels (together also known as ideal cardiovascular health). Our objective was to determine if individuals with high Lp(a) levels could derive cardiovascular benefits if characterized by ideal cardiovascular health...
January 2017: Atherosclerosis
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