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Ravi Jain, Gerardo Moreno Arias, Pablo Naranjo, Max Murison, Jose Luis López Estebaranz, Alina Fratila, Welf Prager, Carlos Guillén Barona, Michael Weidmann, Serge Dahan, Hugues Cartier, Gerhard Sattler, Maurizio Podda
INTRODUCTION: A variety of topical anesthetic creams are available to reduce pain associated with dermatological procedures. Pliaglis is a self-occluding eutectic mixture of lidocaine and tetracaine. STUDY OBJECTIVES: To evaluate the post-marketing safety profile of Pliaglis and efficacy in terms of pain reduction, product satisfaction, and daily practice use prior to pre-defined dermatological procedures. METHODS: A prospective, non-interventional study conducted at 44 sites in four European countries; 581 patients were treated prior to dermatological procedures such as pulsed-dye laser therapy, laser-assisted hair removal, non-ablative laser resurfacing, dermal filler injections, and vascular access...
April 1, 2018: Journal of Drugs in Dermatology: JDD
Milind S Hatwalne
Free radicals are highly reactive and unstable compounds. These highly reactive molecules cause oxidative damage to cellular components such as DNA, proteins and lipids. They play central role in the mechanism of cell injury and cell death. Free radical scavengers either prevent these reactive species from being formed, or remove them before they can damage vital components of the cell. Oxidative stress defines an imbalance in production of oxidizing chemical species and their effective removal by protective antioxidants and scavenger enzymes...
May 2012: Indian Journal of Anaesthesia
D Iu Pushkar', L M Dul'kin, D L Pletner, A V Bormotin, A B Liaginskiĭ
The aim of our study was assessment of efficacy of PLFT technique on ProstaLund CoreTHerm unit in nanagement of acute urine retention in patients with prostatic adenoma. We treated 31 patients with prostatic adenoma (age 58-97, mean age 74 years, volume of the prostatic gland from 32 to 188 ml); 11 patients had suprapubic fistula, 8 carried urethral catheter for acute urinary retention. All the patients were inoperable because of a high surgical-anasthetic risk. All of them were exposed to PLFT for 9-15 min...
November 2009: Urologii︠a︡
No abstract text is available yet for this article.
August 1964: Biochemical Pharmacology
A Virgili, M L Scapellato, I Macceå, M Perini, M Carrieri, G Gori, B Saita, G B Bartolucci
We considered data of samples collected in the period 1994-2001 in 83 operating rooms of 13 different public and private hospitals in Veneto Region. The anaestetic gases more used in operating rooms were nitrous oxide, isoflurane and, more recently, sevflurane. The mostly polluted positions were those in proximity of anaesthesiologic devices; the gases average concentrations were low in all hospitals examined, although some operating rooms demonstrated concentrations of anasthetic gases exceeding limit values...
October 2002: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
Yong Gu, Jing Chen, Haichun Yang, Weiyu Zhu, Fan Lin, Chunxiao Zhu, Shantan Lin
OBJECTIVE: To investigate the changes of angiotensin II type 1 (AT1) receptor in the kidney of spontaneously hypertensive rats (SHR) with diabetes and the influence of endothelin receptor antagonist bosentan. METHODS: Streptozotocin-induced diabetic SHR were divided into four groups: groups treated by cilazapril, bosentan + amlodipine, and amlodipine rsspectively, and untreated group, 6 rats in each group. Six SHR rats and six WKY rats were used as hypertensive and normotensive controls respectively...
January 10, 2002: Zhonghua Yi Xue za Zhi [Chinese medical journal]
S E Plastow, J E Hall, S C Pugh
Sevoflurane induction of anasthesia has been examined extensively, but little is known about the usefulness of other drugs as adjuncts to hasten and smooth the process. Sixty patients, undergoing surgery of a type suitable for a spontaneous respiration, laryngeal mask airway anasthetic technique, were randomly allocated to receive 1.0 intravenous fentanyl or the equivalent volume of normal saline, 30 s prior to triple-breath induction with sevoflurane. The study was double-blind. There were no differences between the groups for the times to loss of eyelash reflex, jaw relaxation, insertion of the laryngeal mask airway or regular settled breathing...
May 2000: Anaesthesia
D Breslin, J Reid, A Hayes, R K Mirakhur
A patient with a known history of myotubular myopathy presented for surgery for insertion of a tibial nail. Anasthesia was induced and maintained using an intravenous anasthetic technique. Neuromuscular function was assessed using mechanomyography, which showed a profound reduction in muscle contractility. In view of this, the use of muscle relaxants was avoided altogether. Nerve conduction was normal but electromyography showed small motor units, with generalised distribution, suggesting mild to moderately severe myopathy...
May 2000: Anaesthesia
S C Hodges, A M Hodges
A project to perform surgical correction of cleft lips and palates was carried out in Uganda in 1998. Twenty centres were visited and 336 cleft lips and 41 cleft palates were repaired. The age of the patients ranged from 2 weeks to 60 years. Many of the centres visited were remote and lacked even the most basic equipment. Patients were anasthetised using ketamine, ether or halothane according to a protocol that we developed. There was no anasthetic mortality and only one case of significant morbidity. We report our experience and discuss recommendations regarding the provision of anasthesia in remote circumstances based on our outcome...
May 2000: Anaesthesia
(no author information available yet)
No abstract text is available yet for this article.
April 11, 1997: Sygeplejersken
M Reverte, J Moratinos
The aim of this study was to investigate in rabbits the diastolic arterial blood pressure, plasma glucose and plasma lactate responses to salbutamol (a selective beta-2 adrenoceptor agonist) and BRL 37344 (a selective beta-3 adrenoceptor agonist) in comparison with CGP 12177 (a potent beta-1 and beta-2 adrenoceptor antagonist which also acts as a partial beta-3 agonist), isoprenaline (a non-selective beta-1, beta-2 and beta-3 adrenoceptor agonist) and adrenaline (a non-selective beta and alpha adrenoceptor agonist)...
1994: Fundamental & Clinical Pharmacology
M P Motsnyĭ, O A Shugurov, O O Shugurov
The influence of constant current passing through the spinal cord cross-section on the antidromic discharges in afferent nerves caused by intraspinal stimulation of central afferent terminals was studied in experiments on anasthetized cats. The current flowing through the spinal cord in the dorso-ventral direction produced an increase or antidromic discharges. The current flowing in the ventro-dorsal direction produced an opposite effect. Facilitation of antidromic discharges evoked by conditioning stimuli decreased with an increase of constant current of both directions...
1982: Neir̆ofiziologiia, Neurophysiology
H W Dove
Phencyclidine (PCP), discovered in Germany during the 1920s, has become over the past four decades the number one drug of abuse in the United States. While briefly showing promise as being the "ultimate" anasthetic agent during the late 1950s, it very quickly fell into disfavor because of untoward side-effects during post-anesthetic emergence (1960s). Some few years later (1970s), PCP began its ascent in the illicit drug market. PCP is a drug with a broad range of pharmacological activity. It has been implicated as a major cause of psychiatric decompensation and has a number of clinical syndromes described in the literature...
June 1984: Psychiatric Medicine
G Torri, G Damia, M L Fabiani
The effect of nitrous oxide on the minimum alveolar concentration of enflurane required to prevent movement in response to skin incision in 50% of subjects (MAC) has been investigated in two groups of 16 patients. The end-tidal enflurane concentration was held constant for 25-36 min in order to equilibrate the brain with the alveolar anasthetic partial pressure. When nitrous oxide (30%) was present in the inspired mixture the MAC of enflurane was 1.17%; the value decreased to 0.57% when 70% nitrous oxide was used...
July 1974: British Journal of Anaesthesia
N G Sliusar', A N Kudrin
No abstract text is available yet for this article.
November 1966: Farmakologiia i Toksikologiia
S Chiarenza, E G Rosato, G Spinella, S Romeo
Having confirmed the development of cephalea in a large number of patients undergoing saphenectomy under subarachnoidal anasthetic, the authors wanted to research its probable causes. With this in mind, they observed a group of patients who had varices of the lower limbs which they had operated. They present their study methodology, and then examine and discuss the results. The conclude that many factors are responsible for the aetiology of the symptoms of cephalea. The sex, age, and conditions of venous hypertension in the posterior tibial vein are particularly determining factors...
July 1986: Phlébologie
F Thimm, I Ludwig, L Schöning
One hindleg of an anasthetized rat (n = 15) was isolated from systemic blood circulation. The preparation was connected to the body only by nerve and bone. A. and V. femorales were cannulated and perfused with normoxic (PO2 = 530 mm Hg) or hypoxic (PO2 = 60 mm Hg) Tyrode solutions. Static contractions of the muscle were elicited by electrical stimulation on the sciatic nerve (2 x motor threshold, 400-800 mV, 50 s-1). A 1 s stimulus was followed by a 2 s rest period. Total test time amounted to 40 min. It was proceeded and succeeded by 20 min periods of control perfusions without stimulation...
July 1988: Pflügers Archiv: European Journal of Physiology
T M Hamm, R M Reinking, D G Stuart
Evidence is presented that marked changes in the electromyographic (EMG) activity of single motor units often occur during a fatigue-test paradigm (12) widely used for the classification of mammalian motor units into fast-fatigable (FF), fast-intermediate-fatigable, fast-fatigue-resistant and slow categories (11), particularly in type FF units. Force output and EMG activity were measured in single motor units of the tibialis posterior muscle of anasthetized cats, while each unit was subjected to a fatigue test consisting of 4 min of motor-axon stimulation, using 1 Hz 330 ms trains of 0...
November 1989: Electromyography and Clinical Neurophysiology
P T Männistö, L Saarnivaara
The effects of acute and long-term lithium (LiCl) and rubidium chloride (RbCl) treatments on the sleeping time caused by intravenous thipentone, methohexitone, ketamine, propanidid. Althesin and diazepam were studied in white mice. The doses of the anasthetic agents were selected from the dose-response experiments. When given acutely, LiCl 5 m-equiv/kg prolonged significantly the sleeping time caused by both of the barbiturates, whereas RbCl given for 21 days in tap water shortened the sleeping time induced by methohexitone and ketamine...
March 1976: British Journal of Anaesthesia
R Szulc, J Knapowski
The authors studied the effect of halothane on active transport of sodium in the epithelial cells using the method described by Ussing with frog skin as an experimental model. It was found that the action of the anasthetic agent on the active transport of sodium was biphasic, and this observation confirmed the results obtained with another experimental model. It was observed, moreover, that the mechanism of halothane action on the cell membrane it not identical with that of vasopressin, which was used in some of the present experiments before adding halothane...
October 1975: Anaesthesia, Resuscitation, and Intensive Therapy
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