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Neurogenic overactive bladder

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https://www.readbyqxmd.com/read/28098199/optogenetic-modulation-of-urinary-bladder-contraction-for-lower-urinary-tract-dysfunction
#1
Jae Hong Park, Jin Ki Hong, Ja Yun Jang, Jieun An, Kyu-Sung Lee, Tong Mook Kang, Hyun Joon Shin, Jun-Kyo Francis Suh
As current clinical approaches for lower urinary tract (LUT) dysfunction such as pharmacological and electrical stimulation treatments lack target specificity, thus resulting in suboptimal outcomes with various side effects, a better treatment modality with spatial and temporal target-specificity is necessary. In this study, we delivered optogenetic membrane proteins, such as channelrhodopsin-2 (ChR2) and halorhodopsin (NpHR), to bladder smooth muscle cells (SMCs) of mice using either the Cre-loxp transgenic system or a viral transfection method...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28065810/risk-factors-associated-with-recurrent-urinary-tract-infection-in-neurogenic-bladders-managed-by-clean-intermittent-catheterization
#2
Rajeev Chaudhry, Zarine R Balsara, Ramiro J Madden-Fuentes, John S Wiener, Jonathan C Routh, Patrick Seed, Sherry S Ross
INTRODUCTION: Patients with neurogenic bladder secondary to spina bifida or tethered cord are at increased risk of recurrent urinary tract infections (UTI). Our objective was to identify risk factors for recurrent UTI in these patients who perform clean intermittent catheterization (CIC). METHODS: A six year retrospective chart review of patients with spina bifida or tethered cord who perform CIC (age 8 mos-58 yrs) was conducted. A strict case definition for UTI was applied, and per subject UTI events, demographic, and clinical data were abstracted...
January 5, 2017: Urology
https://www.readbyqxmd.com/read/28060912/early-fesoterodine-fumarate-administration-prevents-neurogenic-detrusor-overactivity-in-a-spinal-cord-transected-rat-model
#3
Xavier Biardeau, Mikolaj Przydacz, Shachar Aharony, George Loutochin, Lysanne Campeau, Maeva Kyheng, Jacques Corcos
BACKGROUND: In spinal cord injury, onset of detrusor overactivity (DO) is detrimental for quality of life (incontinence) and renal risk. Prevention has only been achieved with complex sophisticated electrical neuromodulation techniques. PURPOSE: To assess the efficacy of early fesoterodine fumarate (FF) administration in preventing bladder overactivity in a spinal cord transected (SCT) rat model. METHODS: 33 Sprague-Dawley rats were allocated to 6 groups-Group 1: 3 normal controls; Group 2: 6 SCT controls; Group 3: 6 SCT rats + FF 0...
2017: PloS One
https://www.readbyqxmd.com/read/27988174/-medico-economic-evaluation-of-urological-cares-of-spinal-cord-injured-patients-a-review
#4
C Guillot-Tantay, E Chartier-Kastler, Q Manach, M-A Perrouin-Verbe, P Denys, V Phé
INTRODUCTION: To provide an overview of the urological management of spinal cord injured patients based on an economic analysis. MATERIALS AND METHODS: A literature search from January 1994 to December 2014 was performed using Medline and Embase database using the following keywords: cost-effectiveness; cost-benefit; cost-utility; spinal cord injury; neurogenic bladder; intermittent catheterization; antimuscarinics; botulinum toxin; sacral neuromodulation; tibial nerve; Brindley; sphincterotomy...
January 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/27979540/re-conjoint-urological-society-of-australia-and-new-zealand-usanz-and-urogynaecological-society-of-australasia-ugsa-guidelines-on-the-management-of-adult-non-neurogenic-overactive-bladder
#5
https://www.readbyqxmd.com/read/27955902/-prospective-evaluation-of-mouth-and-eye-dryness-induced-by-antimuscarinic-drugs-used-for-neurogenic-overactive-bladder-in-35%C3%A2-patients-with-multiple-sclerosis
#6
L Weglinski, P Manceau, M Thomas-Pohl, F Le Breton, G Amarenco
INTRODUCTION: Mouth and eye dryness are frequently reported by patients with multiple sclerosis (MS) as side effects of antimuscarinic drugs used for neurogenic overactive bladder. We evaluated the impact of antimuscarinic drugs prescription on these symptoms. METHODS: MS patients consulting for overactive bladder were included. Xerostomia were evaluated at baseline and thirty days after treatment by self-reporting questionnaires (Xerostomia Quality of Life [X-Qol] and Xerostomia Questionnaire [XQ]), by salivary flow rate and sugar test...
December 7, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27871929/past-present-and-future-of-chemodenervation-with-botulinum-toxin-in-the-treatment-of-oab
#7
Pradeep Tyagi, Mahendra Kashyap, Naoki Yoshimura, Michael Chancellor, Christopher J Chermansky
PURPOSE: We systematically reviewed both pre-clinical and clinical studies on bladder chemodenervation with onabotulinumtoxin A to highlight current limitations and future drug delivery approaches. MATERIALS AND METHODS: We identified peer-reviewed basic and clinical research studies of onabotulinumtoxin A (onaBoNT-A) in the treatment of neurogenic bladder and refractory idiopathic overactive bladder (OAB) published between March 2000 and March 2016. Paired investigators independently screened 125 English language articles to identify controlled studies on onaBoNT-A administration in MEDLINE® database and abstracts presented at annual American Urological Association meetings...
November 18, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27819757/urethral-pressure-variation-a-neglected-contributing-factor-in-patients-with-overactive-bladder-syndrome
#8
Kirschner-Hermanns Ruth, Anding Ralf, Gadzhiev Nariman, Campbell Adele, Goping Ing, Huppertz Nadine
OBJECTIVE: To study urethral pressure variations during the whole filling phase among different groups of patients. MATERIAL AND METHODS: We investigated 79 consecutive patients from January 2011 to June 2012. All patients were recruited within our routine practice in our continence clinic and were evaluated with urodynamic exam according to the standards of the International Continence Society (ICS) with an additional continuous measurement of the urethral pressure profile (cUPP) that was done in a supine position...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27816462/-lower-urinary-tract-dysfunction-in-normal-pressure-hydrocephalus-review-of-the-literature
#9
E Bey, B Nicot, O Casez, L Le Normand
INTRODUCTION: Lower urinary tract dysfunction in normal pressure hydrocephalus has received little attention from the scientific community. The aim of this review article was to discuss diagnostic and therapeutic options for these patients. SOURCES: A literature review of MedLine publications on urinary incontinence in normal pressure hydrocephalus was conducted. The following keywords were used: "hydrocephalus, normal pressure" and "bladder dysfunction" or "urinary incontinence" or "overactive bladder" or "urinary bladder, neurogenic"...
December 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27813141/renal-deterioration-after-spinal-cord-injury-is-associated-with-length-of-detrusor-contractions-during-cystometry-a-study-with-a-median-of-41-years-follow-up
#10
Marlene Elmelund, Niels Klarskov, Per Bagi, Peter S Oturai, Fin Biering-Sørensen
AIMS: To investigate which urodynamic parameters are associated with renal deterioration over a median of 41 years follow-up after traumatic spinal cord injury. METHODS: Medical records of patients with a traumatic spinal cord injury sustained 1944-1975 were reviewed from time of injury until 2012. Patients who attended regular renography and/or renal clearance examinations and had minimum one cystometry and pressure-flow study were included. Renal deterioration was diagnosed as split renal function ≤30% in one kidney or relative glomerular filtration rate ≤51% of expected according to age and gender...
November 4, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27765580/comparison-of-different-antibiotic-protocols-for-asymptomatic-bacteriuria-in-patients-with-neurogenic-bladder-treated-with-botulinum-toxin-a
#11
Ana Claudia Paradella, André Ferraz de Arruda Musegante, Carlos Brites
Intravesical botulinum toxin A (BoNTA) injection has been widely used for the treatment of detrusor overactivity in patients with neurogenic bladder due to spinal cord injury who do not respond to conventional treatment. There is no consensus about antibiotic prophylaxis for this procedure. We conducted a retrospective analysis of medical records of adult patients with spinal cord injury who underwent detrusor BoNTA injection between January of 2007 and December of 2013 in a rehabilitation hospital. Occurrence of symptomatic urinary tract infection (UTI) was assessed in 3 groups in accordance with their use of antibiotics (prophylactic dosage, 3 days, more than 3 days) for the treatment of asymptomatic bacteriuria...
November 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27752863/effects-of-daily-tadalafil-on-lower-urinary-tract-symptoms-in-young-men-with-multiple-sclerosis-and-erectile-dysfunction-a-pilot-study
#12
D Francomano, A Ilacqua, A Cortese, G Tartaglia, A Lenzi, M Inghilleri, A Aversa
PURPOSE: Men affected by multiple sclerosis often experience neurogenic overactive bladder (OAB), lower urinary tract symptoms and erectile dysfunction (ED). The aim of the study was to investigate modifications of urinary and sexual functions after administration of daily tadalafil (TAD) 5 mg. METHODS: Twenty men were enrolled in a single-blind, 4-week prospective study while 10 men without treatment served as controls. Primary outcomes were changes from baseline of International Prostate Symptom (IPSS), OAB questionnaire (OAB-q-short form) and International Index of Erectile Function (IIEF-5) scores...
October 17, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27676764/botulinum-toxin-therapy-for-neurogenic-detrusor-hyperactivity-versus-augmentation-enterocystoplasty-impact-on-the-quality-of-life-of-patients-with-sci
#13
Charles Fattal, Claire Anquetil, Samer Abdelhamid
OBJECTIVE: To compare quality of life (QoL) in patients with spinal cord injury who underwent overactive detrusor treatment by Botulinum Toxin (BT) versus augmentation cystoplasty (AC). MATERIALS/PATIENTS AND METHODS: Prospective and descriptive study. Patients with refractory overactive bladder due to SCI were treated by at least 2 successive injections of BT or by AC. QoL was assessed using Qualiveen-30 (Q30). Clinical data and urodynamic parameters were collected and compared...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676714/long-term-real-life-efficacy-of-onabotulinum-toxin-a-for-the-treatment-of-neurogenic-detrusor-overactivity-in-a-population-using-intermittent-self-catheterization
#14
Charles Joussain, Mélanie Popoff, Véronique Phé, Alexia Even, Laetitia Falcou, Emmanuel Chartier-Kastler, Brigitte Schurch, Pierre Denys
OBJECTIVE: Intradetrusor injection of onabotulinum toxin A (IDIBA) is the third-line therapy for patients with neurogenic detrusor overactivity (NDO). There is few evidence of long-term efficacy but no study assessed reasons for failure or abandonment of IDIBA and CISC (clean intermittent self-catheterization) combined strategy. We aimed to assess its long-term outcome in NDO management, and analyze failure and discontinuation. MATERIALS/PATIENTS AND METHODS: We retrospectively reviewed medical records of patients admitted in our neurourology department between 2001 and 2013...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676712/efficacy-and-safety-of-a-first-intradetrusorial-injection-of-botulinum-toxin-a-for-the-treatment-of-refractory-overactive-bladder-in-54-elderly-patients
#15
Laura Weglinski, Rebecca Haddad, Benoit Peyronnet, Xavier Game, Calin Ciofu, Gerard Amarenco
OBJECTIVE: Intradetrusorial injection of botulinum toxin A (IDBT) is a validated treatment for neurogenic and non-neurogenic refractory overactive bladder. In the elderly, muscarinic antagonists have many side effects, in particular in cognition. An alternative treatment is, for that reason, interesting in this frail population with multiple medication use. The question of efficacy is remaining. Indeed, bladder dysfunction is most of the time a multifactorial issue in the elderly. The objective of this study was to evaluate prospectively the efficacy and safety of IDBT in this population...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27596481/preserved-micturition-after-intradetrusor-onabotulinumtoxina-injection-for-treatment-of-neurogenic-bladder-dysfunction-in-parkinson-s-disease
#16
Stephanie C Knüpfer, Susanne A Schneider, Mareike M Averhoff, Carsten M Naumann, Günther Deuschl, Klaus-Peter Jünemann, Moritz F Hamann
BACKGROUND: To assess the efficacy and safety of intradetrusor onabotulinumtoxinA (OnabotA) injection treatment in patients with neurogenic lower urinary tract dysfunction (NLUTD), especially for patients with Parkinson disease (PD). METHODS: PD patients refractory to oral antimuscarinic participated in an off-label use study and were evaluated prior and after 200 IU OnabotA injection into detrusor muscle, including trigone. Changes due to treatment were evaluated using bladder diaries, urodynamics, and questionnaires...
September 5, 2016: BMC Urology
https://www.readbyqxmd.com/read/27527382/pathophysiology-clinical-importance-and-management-of-neurogenic-lower-urinary-tract-dysfunction-caused-by-suprasacral-spinal-cord-injury
#17
REVIEW
H Z Hu, N Granger, N D Jeffery
Management of persistent lower urinary tract dysfunction resulting from severe thoracolumbar spinal cord injury can be challenging. Severe suprasacral spinal cord injury releases the spinal cord segmental micturition reflex from supraspinal modulation and increases nerve growth factor concentration in the bladder wall, lumbosacral spinal cord, and dorsal root ganglion, which subsequently activates hypermechanosensitive C-fiber bladder wall afferents. Hyperexcitability of bladder afferents and detrusor overactivity can cause urine leaking during the storage phase...
September 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27494539/mucosal-modulation-of-contractility-in-bladder-strips-from-normal-and-overactive-rat-models-and-the-effect-of-botulinum-toxin-a-on-overactive-bladder-strips
#18
Patrick C Campbell, Bronagh McDonnell, Kevin P Monaghan, Lauren Baysting, Oonagh Little, Karen D McCloskey
AIMS: To investigate the local, regulatory role of the mucosa on bladder strip contractility from normal and overactive bladders and to examine the effect of botulinum toxin A (BoNT-A). METHODS: Bladder strips from spontaneously hyperactive rat (SHR) or normal rats (Sprague Dawley, SD) were dissected for myography as intact or mucosa-free preparations. Spontaneous, neurogenic and agonist-evoked contractions were investigated. SHR strips were incubated in BoNT-A (3 h) to assess effects on contractility...
August 5, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27401178/neurogenic-lower-urinary-tract-dysfunction-evaluation-and-management
#19
Katarina Ivana Tudor, Ryuji Sakakibara, Jalesh N Panicker
The lower urinary tract (LUT) in health is regulated by coordinated multi-level neurological inputs which require an intact central and peripheral nervous system. Lower urinary tract dysfunction is, therefore, a common sequelae of neurological disease and the patterns of bladder storage and voiding dysfunction depend upon the level of neurological lesion. Evaluation includes history taking, bladder diary, urological examination when relevant, ultrasonography and urodynamic testing when indicated. Antimuscarinic agents are the first line treatment for patients with storage dysfunction...
December 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27314246/urodynamic-findings-in-patients-with-creutzfeldt-jakob-disease-a-case-report
#20
Masashi Yano, Ryuji Sakakibara, Fuyuki Tateno, Osamu Takahashi, Haruka Nakamura, Megumi Sugiyama, Lee Fang-Ching, Syuichi Kamijima, Naoto Kamiya, Hiroyoshi Suzuki
AIM OF STUDY: Urinary dysfunction in Creutzfeldt-Jakob disease (CJD) patients is attributed to functional incontinence, since they often have immobility and loss of motivation. In contrast, previously no urodynamic findings are available in CJD patients. CASE REPORT: We had 2 CJD patients who had urinary frequency and urinary retention. We performed urodynamics with the spouse's informed consent in order to explore the mechanism of urinary dysfunction in those cases...
October 2016: International Urology and Nephrology
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