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Benign biliary stricture

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https://www.readbyqxmd.com/read/27914884/clinical-presentation-diagnosis-and-survival-in-cholangiocarcinoma-a-prospective-study
#1
Larisa Vasilieva, Stefanos I Papadhimitriou, Alexandra Alexopoulou, Ioannis Kostopoulos, Konstantinos Papiris, Dimitrios Pavlidis, Dimitrios Xinopoulos, Andreas Romanos, Spyridon P Dourakis
BACKGROUND AND STUDY AIMS: The diagnosis of cholangiocarcinoma (CCA) is difficult. The present study aimed to assess the clinical features, diagnosis, and survival in CCA. PATIENTS AND METHODS: This is a prospective study on 46 patients with CCA who underwent endoscopic retrograde cholangiopancreatography (ERCP) or surgical resection and 20 controls with a clinical and ERCP suspicion for CCA in whom surgical biopsy and/or 4-year follow-up showed a benign biliary stricture...
November 30, 2016: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/27904249/benign-biliary-strictures
#2
REVIEW
Ashley Altman, Steven M Zangan
Differentiating benign and malignant biliary strictures is a challenging and important clinical scenario. The typical presentation is indolent and involves elevation of liver enzymes, constitutional symptoms, and obstructive jaundice with or without superimposed or recurrent cholangitis. While overall the most common causes of biliary strictures are malignant, including cholangiocarcinoma and pancreatic adenocarcinoma, benign strictures encompass a wide spectrum of etiologies including iatrogenic, autoimmune, infectious, inflammatory, and congenital...
December 2016: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/27894928/per-oral-video-cholangiopancreatoscopy-with-narrow-band-imaging-for-the-evaluation-of-indeterminate-pancreaticobiliary-disease
#3
Rawad Mounzer, Gregory L Austin, Sachin Wani, Brian C Brauer, Norio Fukami, Raj J Shah
BACKGROUND AND AIMS: Cholangiopancreatoscopy in evaluating pancreaticobiliary pathology is currently limited by suboptimal optics. The aim of this study was to characterize the operating characteristics of per-oral video cholangiopancreatoscopy with narrow-band imaging (POVCP) findings in indeterminate pancreaticobiliary disease and describe their association with neoplasia. METHODS: Data from consecutive patients undergoing POVCP for the evaluation of indeterminate pancreaticobiliary disease at a single tertiary care center were analyzed...
November 25, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27806808/tetramethylpyrazine-effects-on-the-expression-of-scar-related-genes-in-rabbit-benign-biliary-stricture-fibroblasts
#4
Ke Yue Li, Cheng Xian Shi, Jian Zhao Huang, Ke Li Tang
OBJECTIVE: To investigate the effects of tetramethylpyrazine (TMP) on transforming growth factor-β1 (TGF- β1), α-smooth muscle actin (α-SMA), and neuronal regeneration related protein (P311) in benign biliary stricture fibroblasts of rabbit. STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: Guizhou Medical University, Guiyang, Guizhou, China, from April to December 2015. METHODOLOGY: Fibroblasts isolated from rabbits following benign biliary stricture were cultured and treated with different concentrations of TMP(0...
October 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27806633/surveillance-of-primary-sclerosing-cholangitis-with-erc-and-brush-cytology-risk-factors-for-cholangiocarcinoma
#5
Sonja Boyd, Harri Mustonen, Andrea Tenca, Kalle Jokelainen, Johanna Arola, Martti A Färkkilä
OBJECTIVE: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease leading to bile duct strictures and fibrosis, and predisposing to cholangiocarcinoma (CCA). Biliary dysplasia is a known precursor of CCA. In our unit, PSC patients undergo regular surveillance with ERC and brush cytology (BC), and liver transplantation is an option in case with biliary dysplasia. We evaluated the risk factors for biliary dysplasia and CCA based on ERC imaging, BC and liver function tests...
November 3, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27797266/identification-of-pancreatic-cancer-in-biliary-obstruction-patients-by-fry-site-specific-methylation
#6
Phonthep Angsuwatcharakon, Rungsun Rerknimitr, Pradermchai Kongkam, Wiriyaporn Ridtitid, Yuwadee Ponauthai, Ratakorn Srisuttee, Nakarin Kitkumthorn, Apiwat Mutirangura
BACKGROUND: Methylation at cg 16941656 of FRY is exclusively found in normal pancreatic tissue and has been proven to be specific for pancreatic-in-origin among several adenocarcinomas. Here, we investigated methylated DNA in the bile as a biomarker to differentiate the cause of obstruction between pancreatic cancer and benign causes. MATERIALS AND METHODS: Bile samples of 45 patients with obstructive jaundice who underwent ERCP were collected and classified into pancreatic cancer (group 1) and benign causes (group 2) in 24 and 21 patients, respectively...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27777109/in-silico-analysis-of-differential-gene-expressions-in-biliary-stricture-and-hepatic-carcinoma
#7
Manoj Kumar Gupta, Santosh Kumar Behara, Ramakrishna Vadde
In-silico attempt was made to identify the key hub genes which get differentially expressed in biliary stricture and hepatic carcinoma. Gene expression data, GSE34166, was downloaded from the GEO database, which contains 10 biliary stricture samples (4 benign control and 6 malignant carcinoma), for screening of key hub genes associated with the disease. R packages scripts were identified 85 differentially expressed genes. Further these genes were uploaded in WebGestalt database and identified nine key genes...
January 15, 2017: Gene
https://www.readbyqxmd.com/read/27765727/aspirin-use-is-associated-with-reduced-risk-of-occlusion-of%C3%A2-metallic-biliary-stents
#8
Sunguk Jang, Tyler Stevens, Mansour A Parsi, Rocio Lopez, John J Vargo
BACKGROUND & AIMS: Biliary self-expandable metallic stents (SEMSs) are widely used to treat malignant and benign conditions of bile duct. Despite their lower rate of occlusion and longer patency than plastic stents, SEMSs still have significant rates of occlusion. We aimed to identify factors associated with occlusion of biliary SEMS. METHODS: We performed a retrospective study of consecutive patients who underwent endoscopic retrograde cholangiopancreatography with biliary SEMS placement at the Cleveland Clinic Foundation from March 2011 to April 2016...
October 17, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27744539/side-by-side-placement-of-bilateral-endoscopic-metal-stents-for-the-treatment-of-postoperative-biliary-stricture
#9
Seiji Kaino, Manabu Sen-Yo, Shuhei Shinoda, Michitaka Kawano, Hirofumi Harima, Shigeyuki Suenaga, Isao Sakaida
Postoperative biliary strictures are usually complications of cholecystectomy. Endoscopic plastic stent prosthesis is generally undertaken for treating benign biliary strictures. Recently, fully covered metal stents have been shown to be effective for treating benign distal biliary strictures. We present the case of a 53-year-old woman with liver injury in which imaging studies showed a common hepatic duct stricture. Endoscopic retrograde cholangiopancreatography also confirmed the presence of a common hepatic duct stricture...
October 15, 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27729733/review-of-endoscopic-radiofrequency-in-biliopancreatic-tumours-with-emphasis-on-clinical-benefits-controversies-and-safety
#10
REVIEW
María-Victoria Alvarez-Sánchez, Bertrand Napoléon
Most pancreatic cancers and extrahepatic cholangiocarcinomas are unresectable at the time of diagnosis, and even in case of a resectable cancer, for elderly or patients with coexistent comorbidities, surgery is not an option. Current treatment alternatives in these scenarios are very limited. Biliary stenting with self-expanding metal stents (SEMS) is the mainstay palliative treatment of biliary obstruction due to unresectable pancreatic cancer or cholangiocarcinoma. Nevertheless, more than 50% of SEMS become occluded after 6 mo due to tumour over- and ingrowth, leading to hospital readmissions and reinterventions that significantly impair quality of life...
October 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27708488/efficacy-of-multidetector-row-computed-tomography-as-a-practical-tool-in-comparison-to-invasive-procedures-for-visualization-of-the-biliary-obstruction
#11
Abdolmajid Taheri, Ayoob Rostamzadeh, Alireza Gharib, Daryoush Fatehi
INTRODUCTION: Recently, multidetector computed tomography (MDCT) has been introduced into clinical practice. MDCT has become the noninvasive diagnostic test of choice for detailed evaluation of biliary obstruction. AIM: the main objective of the present study was to evaluate the diagnostic value of MDCT compared to invasive procedures for detecting biliary obstruction causes. MATERIAL AND METHODS: Since February 2009 until May 2011 fifty biliary obstruction patients based on clinical, laboratory or ultrasonographic findings, were evaluated by Multidetector-row computed tomography...
July 16, 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/27681297/clinical-outcome-of-endoscopic-covered-metal-stenting-for-resolution-of-benign-biliary-stricture-systematic-review-and-meta-analysis
#12
Xiao Zheng, Jun Wu, Bo Sun, Ye-Chen Wu, Zhi-Yuan Bo, Wei Wan, Dao-Jian Gao, Bing Hu
BACKGROUND AND AIM: Management of benign biliary stricture is challenging. Endoscopic therapy has evolved as the first-line treatment for various benign biliary strictures. However, covered self-expandable metal stents (CSEMS) have not been approved by the United States Food and Drug Administration for the treatment of benign biliary stricture. With this goal, we conducted the present systemic review and meta-analysis to evaluate the efficacy and safety of endoscopic stenting with CSEMS in the treatment of benign biliary stricture...
September 28, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/27677284/percutaneous-hepaticojejunostomy-using-a-radiofrequency-wire-for-management-of-a-postoperative-bile-leak
#13
Orrie N Close, Olaguoke Akinwande, Rakesh K Varma, Ernesto Santos, Hyun S Kim
Postoperative biliary complications following extensive hepatic resections are complex, often requiring a multidisciplinary team approach. We describe a case of a free bile duct leak following extended right hepatectomy and surgical hepaticojejunostomy treated with percutaneous transhepatic hepaticojejunostomy in which a radiofrequency guidewire was used to gain enteral access. A modified internal/external biliary catheter was left in place. The patient was enrolled in a benign biliary stricture protocol, and 8 months later, the catheter was removed following a normal cholangiogram and biliary manometric perfusion testing...
September 27, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27652308/performance-of-bile-aspiration-plus-brushing-to-diagnose-malignant-biliary-strictures-during-endoscopic-retrograde-cholangiopancreatography
#14
Gael S Roth, Philippe Bichard, Michele Fior-Gozlan, Hubert Roth, Jean Auroux, Olivier Risse, Christian Letoublon, Marie Hélène Laverrière, Ivan Bricault, Vincent Leroy, Thomas Decaens
BACKGROUND AND STUDY AIMS: Endobiliary brushing during endoscopic retrograde cholangiopancreatography (ERCP) is the main technique used to diagnose a malignant stricture, but has a poor sensitivity. This study evaluated the diagnostic performance of bile aspiration associated with biliary brushing during ERCP to diagnose a malignant stricture, compared to brushing alone. PATIENTS AND METHODS: Between January 2007 and December 2012, all consecutive patients undergoing ERCP to treat a biliary stricture were included...
September 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27644677/plasma-lipidomics-as-a-tool-for-diagnosis-of-extrahepatic-cholangiocarcinoma-in-biliary-strictures-a-pilot-study
#15
Varayu Prachayakul, Phataraphong Thearavathanasingha, Chanitra Thuwajit, Sittiruk Roytrakul, Janthima Jaresitthikunchai, Peti Thuwajit
Biliary obstruction is a common clinical manifestation of various conditions, including extrahepatic cholangiocarcinoma. However, a screening test for diagnosis of extrahepatic cholangiocarcinoma in patients with biliary obstruction is not yet available. According to the rationale that the biliary system plays a major role in lipid metabolism, biliary obstruction may interfere with lipid profiles in the body. Therefore, plasma lipidomics may help indicate the presence or status of disease in biliary obstruction suspected extrahepatic cholangiocarcinoma...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27619787/treatment-of-completely-obstructed-benign-biliary-strictures-with-magnetic-compression-anastomosis-follow-up-results-after-recanalization
#16
Sung Ill Jang, Kwang-Hun Lee, Hong Jin Yoon, Dong Ki Lee
BACKGROUND & AIMS: Although non-surgical methods produce high clinical success rates in the treatment of benign biliary stricture (BBS), conventional methods are not always successful in cases of severe biliary stricture or complete obstruction. Therefore, the efficacy of magnetic compression anastomosis (MCA) for treatment of refractory BBS was evaluated in a single-center, nonrandomized study. METHODS: MCA was performed in patients with BBS that was not resolved by conventional endoscopic or percutaneous treatments...
September 9, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27572066/success-and-complications-of-an-intra-ductal-fully-covered-self-expanding-metal-stent-id-fcsems-to-treat-anastomotic-biliary-strictures-as-after-orthotopic-liver-transplantation-olt
#17
Patrick Aepli, Andrew St John, Saurabh Gupta, Luke F Hourigan, Rhys Vaughan, Marios Efthymiou, Arthur Kaffes
BACKGROUND: Anastomotic biliary strictures (AS) after orthotopic liver transplantation (OLT) belong to the most common biliary complications and cause the biggest morbidity burden after OLT. Metal stents for benign biliary strictures are gaining acceptance with many published series. Traditional metal stent designs seem to have poor durability in AS after OLT. Novel intra-ductal stents are showing promise in these strictures. As a result, we designed a special stent with an antimigration waist and a short stent length with a long removal string that rests in the duodenum for easy removal...
August 29, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27514703/endoscopic-biodegradable-biliary-stents-in-the-treatment-of-benign-biliary-strictures-the-first-report-in-clinical-use-in-patients
#18
Antti Siiki, Irina Rinta-Kiikka, Juhani Sand, Johanna Laukkarinen
The first clinical experience of endoscopically inserted polydioxanone biodegradable biliary stents (BDBS) in the treatment of benign biliary strictures is reported. Two patients with a benign common bile duct stricture were endoscopically treated with 8 mm bore BDBS in ERC (endoscopic retrograde cholangiography). Both BDBS insertions were technically successful and without adverse events. At six months, the stricture resolution was excellent and BDBS degradation was predicted in repeated magnetic resonance imaging...
August 11, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/27510388/development-of-a-swine-benign-biliary-stricture-model-using-endoscopic-biliary-radiofrequency-ablation
#19
Jin Seok Park, Seok Jeong, Joon Mee Kim, Sang Soon Park, Don Haeng Lee
The large animal model with benign biliary stricture (BBS) is essential to undergo experiment on developing new devices and endoscopic treatment. This study conducted to establish a clinically relevant porcine BBS model by means of endobiliary radiofrequency ablation (RFA). Endoscopic retrograde cholangiography (ERC) was performed on 12 swine. The animals were allocated to three groups (60, 80, and 100 W) according to the electrical power level of RFA electrode. Endobiliary RFA was applied to the common bile duct for 60 seconds using an RFA catheter that was endoscopically inserted...
September 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27442966/role-of-cd15-expression-in-dysplastic-and-neoplastic-tissue-of-the-bile-duct-a-potential-novel-tool-for-differential-diagnosis-of-indeterminate-biliary-stricture
#20
Dirk Walter, Eva Herrmann, Ria Winkelmann, Jörg G Albert, Juliane Liese, Andreas Schnitzbauer, Stefan Zeuzem, Martin-Leo Hansmann, Jan Peveling-Oberhag, Sylvia Hartmann
BACKGROUND AND AIMS: CD15 is expressed by various cancer types; among these are intrahepatic and perihilar cholangiocarcinoma (CCA). The aim of this study was to elucidate CD15 expression in distal CCA as well as in dysplastic biliary tissue and to determine its prognostic significance. METHODS AND RESULTS: Tissue samples from patients with intrahepatic (iCCA, n = 22), perihilar (pCCA, n = 7) and distal CCA (dCCA, n = 15), who underwent surgical resection in the period from 2010 to 2015 were evaluated for CD15 expression...
July 21, 2016: Histopathology
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